Digital Commons Network^™

Does Money Matter? Exploring Pay Disparities For Nursing Faculty Educators, Jacqueline Christianson, Jessica L. Zemlak, Kathryn J. Malin, Lisa M. Grabert

College of Nursing Faculty Research and Publications

Key Takeaways:

• The nurse faculty shortage must be addressed to meet the healthcare needs of the public.
• The salary gap between academic nurse educators and clinical practice nurses likely contributes to the nurse faculty shortage.
• Additional investments are necessary to recruit and retain sufficient nursing faculty.

Mixed Quantum/Classical Theory For Rotationally Inelastic Scattering Of Identical Collision Partners: Revised, Dulat Bostan, Bikramaditya Mandal, Dmitri Babikov

Chemistry Faculty Research and Publications

Mixed quantum/classical theory (MQCT) for the treatment of rotationally inelastic transitions during collisions of two identical molecules, described either as indistinguishable or distinguishable partners, is reviewed. The treatment of two molecules as indistinguishable includes symmetrization of rotational wavefunctions, introduces exchange parity, and leads to state-to-state transition matrix elements different from those in the straightforward treatment of molecules as distinguishable. Moreover, the treatment of collision partners as indistinguishable is eight times faster. Numerical results presented herein for H₂ + H₂, CO + CO and H₂O + H₂O systems indicate good agreement of MQCT calculations …

Scattering In Extreme Environments: General Discussion, Dmitri Babikov

Chemistry Faculty Research and Publications

No abstract provided.

Scattering At Condensed-Phase Surfaces: General Discussion, Dmitri Babikov

Chemistry Faculty Research and Publications

No abstract provided.

Anticancer Drugs Of Lysine Specific Histone Demethylase-1 (Lsd1) Display Variable Inhibition On Nucleosome Substrates, Dulmi Senanayaka, Danyun Zeng, Emre Deniz, Indunil K. Priyankara, Joceline Helmbreck, Owen Schneider, Aashay Mardikar, Aykut Uren, Nicholas J. Reiter

Chemistry Faculty Research and Publications

Lysine specific demethylase-1 (LSD1) serves as a regulator of transcription and represents a promising epigenetic target for anticancer treatment. LSD1 inhibitors are in clinical trials for the treatment of Ewing’s sarcoma (EWS), acute myeloid leukemia, and small cell lung cancer, and the development of robust inhibitors requires accurate methods for probing demethylation, potency, and selectivity. Here, the inhibition kinetics on the H3K4me2 peptide and nucleosome substrates was examined, comparing the rates of demethylation in the presence of reversible [CC-90011 (PD) and SP-2577 (SD)] and irreversible [ORY-1001 (ID) and tranylcypromine (TCP)] inhibitors. Inhibitors were also subject to viability studies in three …

Benzoquinone Ligand-Enabled Ruthenium-Catalyzed Deaminative Coupling Of 2-Aminoaryl Aldehydes And Ketones With Branched Amines For Regioselective Synthesis Of Quinoline Derivatives, Krishna Prasad Gnyawali, Aldiyar Shakenov, Pandula T. Kirinde Arachchige, Chae S. Yi

Chemistry Faculty Research and Publications

The catalytic system generated in situ from the cationic Ru–H complex [(C₆H₆)(PCy₃)(CO)RuH]⁺BF₄– (1) with 2,3,4,5-tetrachloro-1,2-benzoquinone (L1) was found to be highly effective for promoting the deaminative coupling reaction of 2-aminoaryl aldehydes with branched amines to form 2-substituted quinoline products. The analogous deaminative coupling reaction of 2-aminoaryl ketones with branched amines led to the regioselective formation of 2,4-disubstituted quinoline products. A number of biologically active quinoline derivatives including graveolinine and a triplex DNA intercalator have been synthesized by using the catalytic method.

Efficient Synthesis Of Thiazole-Fused Bisnoralcohol Derivatives As Potential Therapeutic Agents, Subrata Roy, Hansa Raj Kc, Sanjay Adhikary, Alexander N. Erickson, Mohammad Abrar Alam

Chemistry Faculty Research and Publications

Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.

Mechanism Of Action Of Kl-50, A Candidate Imidazotetrazine For The Treatment Of Drug-Resistant Brain Cancers, Eric D. Huseman, Anna Lo, Olga Fedorova, James L. Elia, Susan E. Gueble, Kingson Lin, Ranjini K. Sundaram, Jooneseok Oh, Jinchan Liu, Fabian Menges, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Victor S. Batista, Jason M. Crawford, Anna M. Pyle, Ranjit S. Bindra, Seth B. Herzon

Chemistry Faculty Research and Publications

Aberrant DNA repair is a hallmark of cancer, and many tumors display reduced DNA repair capacities that sensitize them to genotoxins. Here, we demonstrate that the differential DNA repair capacities of healthy and transformed tissue may be exploited to obtain highly selective chemotherapies. We show that the novel N3-(2-fluoroethyl)imidazotetrazine “KL-50” is a selective toxin toward tumors that lack the DNA repair protein O⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O⁶-alkylguanine lesions. We establish that KL-50 generates DNA interstrand cross-links (ICLs) by a multistep process comprising DNA alkylation to generate an O⁶-(2-fluoroethyl)guanine (O⁶FEtG) …

Team Situation Awareness, Cohesion, And Autonomic Synchrony, Stephen J. Guastello, Cooper Bednarczyk, Ryan Hagan, Camerhon Johnson, Laura Marscisek, Laura M. Mcguigan, Anthony F. Peressini

Psychology Faculty Research and Publications

Objective

This study evaluated the causal relationships among situation awareness (SA), cohesion, and autonomic synchrony (SE) within teams. SA is often a team effort and should be more accurate in better-functioning teams.

Background

Cohesive teams perform better overall, although the relationship appears reciprocal; the relationship to SA has not been considered previously. SEis a collective neurocognitive activity that has been connected to team coordination, communication, and performance in some circumstances.

Method

In this experiment, 71 undergraduates, organized into 16 teams, played two matches of a first-person shooter computer game and completed self-report measures of cohesion …

The Effects Of School Autonomy On Student Achievement, Frank P. Kastl

Honors College Theses

This paper presents new evidence on the effects of school autonomy over personnel, budgeting, and curriculum on student achievement. I use the 2022 Programme for International Student Assessment (PISA) data, a survey and assessment of students and schools in over 80 countries along with panel data methods. The empirical findings suggest that a greater degree of autonomy over schooling decisions improves achievement in math, science, and reading. However, these improvements are most pronounced in more developed countries.

Aerothermodynamic Analysis Of A Linear Aerospike Fueled With Liquid Methane Using Cfd, Aidan Rowell

Honors College Theses

Renewed interest in manned spaceflight, mostly spurred by the advancement of commercial spacecraft, has led to growing interest in improving the efficiency of rocket engines. Aerospike nozzles have the potential to provide this boost in efficiency to spacecraft and thus lower costs and increase payload capacity. This type of nozzle is what is known as altitude adjusting and can significantly increase efficiency. When paired with propellants such as methane/oxygen, which can be manufactured in-situ on some planetary bodies and has a higher density than traditional propellants like liquid hydrogen/liquid oxygen, even more efficiency gain can be achieved. To understand the …

Stop, Collaborate, And List ‘Em: Creating Local Metadata To Promote User Discovery Of Minoritized Identities In A Stem Collection, Paige Dhyne, Alyssa Nance

Libraries Publications

Historical and modern scientific thought is dominated by the English language, colonized science, patriarchal norms, and Westernized “ways of knowing.” By making materials that lie outside that narrative discoverable (e.g., non-Western science, Indigenous/Aboriginal knowledge, women in science, etc.) we can assert that science is a global endeavor by representing diverse scientists on physical library shelves or ebook “shelves.” The Cataloging and Metadata Librarian and Science and Outreach Librarian at Furman University, a small liberal arts college, collaborated on a project to address discriminatory practices in the catalog records of a subset of the libraries’ STEM collection. Spurred by another project …

A Comprehensive Meta-Analysis Of Tissue Resident Memory T Cells And Their Roles In Shaping Immune Microenvironment And Patient Prognosis In Non-Small Cell Lung Cancer, Aidan Shen, Aliesha Garrett, Cheng-Chi Chao, Dongliang Liu, Chao Cheng, Zhaohui Wang, Chen Qian, Yangzhi Zhu, Junhua Mai, Chongming Jiang

Faculty, Staff and Students Publications

Tissue-resident memory T cells (TRM) are a specialized subset of long-lived memory T cells that reside in peripheral tissues. However, the impact of TRM-related immunosurveillance on the tumor-immune microenvironment (TIME) and tumor progression across various non-small-cell lung cancer (NSCLC) patient populations is yet to be elucidated. Our comprehensive analysis of multiple independent single-cell and bulk RNA-seq datasets of patient NSCLC samples generated reliable, unique TRM signatures, through which we inferred the abundance of TRM in NSCLC. We discovered that TRM abundance is consistently positively correlated with CD4+ T helper 1 cells, M1 macrophages, and resting dendritic cells in the TIME. …

Savings Associated With Surgical Aortic Valve Replacement With A Resilia Tissue Valve Based On Seven-Year Commence Trial Results, Tom Nguyen

All Publications

Background: Bioprostheses with RESILIA tissue demonstrate a reduction in calcification and improve health outcomes in pre-clinical and clinical studies. Prior economic analyses which relied on 5 years of evidence from the COMMENCE trial demonstrate financial savings for RESILIA tissue valves relative to mechanical valves after surgical aortic valve replacement (SAVR). Given the recent release of 7-year COMMENCE data, this economic evaluation updates the estimate for long-run savings of bioprosthetic valves with RESILIA.

Methods: Simulation models estimated disease progression across two hypothetical SAVR cohorts (tissue vs. mechanical) of 10,000 patients each in the US. The primary comparison calculated the SAVR-related expenditures …

Optical Coherence Elastography Measures The Biomechanical Properties Of The Ex Vivo Porcine Cornea After Lasik, Achuth Nair, Fernando Zvietcovich, Manmohan Singh, Mitchell P Weikert, Salavat R Aglyamov, Kirill V Larin

Faculty, Staff and Students Publications

SIGNIFICANCE: The biomechanical impact of refractive surgery has long been an area of investigation. Changes to the cornea structure cause alterations to its mechanical integrity, but few studies have examined its specific mechanical impact.

AIM To quantify how the biomechanical properties of the cornea are altered by laser assisted in situ keratomileusis (LASIK) using optical coherence elastography (OCE) in ex vivo porcine corneas.

APPROACH: Three OCE techniques, wave-based air-coupled ultrasound (ACUS) OCE, heartbeat (Hb) OCE, and compression OCE were used to measure the mechanical properties of paired porcine corneas, where one eye of the pair was left untreated, and the …

Ethical Decision-Making In Older Drivers During Critical Driving Situations: An Online Experiment, Amandeep Singh, Sarah Yahoodik, Yovela Murzello, Samuel Petkac, Yusuke Yamani, Siby Samuel

Psychology Faculty Publications

The present study examined the impact of aging on ethical decision-making in simulated critical driving scenarios. 204 participants from North America, grouped into two age groups (18–30 years and 65 years and above), were asked to decide whether their simulated automated vehicle should stay in or change from the current lane in scenarios mimicking the Trolley Problem. Each participant viewed a video clip rendered by the driving simulator at Old Dominion University and pressed the space-bar if they decided to intervene in the control of the simulated automated vehicle in an online experiment. Bayesian hierarchical models were used to analyze …

Diagnostic Value Of Soluble Urokinase-Type Plasminogen Activator Receptor In Patients With Acute Coronary Syndrome: A Systematic Review And Meta-Analysis, Michal Pruc, Iwona Jannasz, Damian Swieczkowski, Grzegorz Procyk, Aleksandra Gasecka, Zubaid Rafique, Francesco Chirico, Nicola Luigi Bragazzi, Milosz J Jaguszewski, Jaroslaw Wysocki, Lukasz Szarpak

Faculty, Staff and Students Publications

BACKGROUND: In contemporary clinical practice, there is an increasing need for new clinically relevant biomarkers potentially optimizing management strategies in patients with suspected acute coronary syndrome (ACS). This study aimed to determine the diagnostic utility of soluble urokinase-type plasminogen activator receptor (suPAR) levels in individuals with suspected ACS.

METHODS: A literature search was performed in Web of Science, PubMed, Scopus, and the Cochrane Central Register of Controlled Trials databases, for studies comparing suPAR levels among patients with and without ACS groups. The methodological quality of the included papers was assessed using the Newcastle-Ottawa Scale (NOS). A fixed-effects model was used …

Recent Trends In The Incidence Of Gastric Cancer In The United States, Kyle S Liu, Syed Ahsan Raza, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

BACKGROUND: Gastric cancer (GC) incidence rates overall in the United States have declined over recent decades and are predicted to continue declining. However, there have been mixed recent findings regarding the potential stabilization of rates and potential divergent trends by age group. We used the most recent cancer data for the United States and examined trends in GC between 1992 and 2019, overall and in important subgroups of the population.

METHODS: Age-adjusted GC incidence rates and trends in adults 20 years or older were calculated using data from the Surveillance, Epidemiology, and End Results (SEER) 12 program. Secular trends were …

Translational Symmetry In Convolutions With Localized Kernels Causes An Implicit Bias Toward High Frequency Adversarial Examples, Josue O Caro, Yilong Ju, Ryan Pyle, Sourav Dey, Wieland Brendel, Fabio Anselmi, Ankit B Patel

Faculty, Staff and Students Publications

Adversarial attacks are still a significant challenge for neural networks. Recent efforts have shown that adversarial perturbations typically contain high-frequency features, but the root cause of this phenomenon remains unknown. Inspired by theoretical work on linear convolutional models, we hypothesize that translational symmetry in convolutional operations together with localized kernels implicitly bias the learning of high-frequency features, and that this is one of the main causes of high frequency adversarial examples. To test this hypothesis, we analyzed the impact of different choices of linear and non-linear architectures on the implicit bias of the learned features and adversarial perturbations, …

Efficacy Of Etripamil Nasal Spray For Acute Conversion Of Supraventricular Tachycardia: A Network Meta-Analysis, Adam Macech, Nicola Luigi Bragazzi, Francesco Chirico, Basar Cander, Michal Pruc, Zubaid Rafique, William Frank Peacock, Arash Ziapour, Lukasz Szarpak, Anna Salak, Milosz J Jaguszewski

Faculty, Staff and Students Publications

No abstract provided.

Herbicide Management Alters Fungal Biomass And Community Composition In Great Lakes Coastal Wetlands, Erica Danae Lathers

Master's Theses and Doctoral Dissertations

Wetlands provide many ecosystem services, and invasive species and their management can alter these services. Plant responses to wetland management actions are typically monitored, but less is known about how soils respond. Phragmites australis, an invasive wetland plant, can alter soil conditions, potentially impacting soil microbial structure and function. We sampled soil communities in Great Lakes coastal wetlands in southeastern Michigan dominated by Phragmites and sites that had been previously invaded by Phragmites then treated with herbicide from 2011-2017, to understand how herbicide management alters soil fungal communities. We assessed microbial and fungal biomass, fungal community composition, greenhouse gas emissions, …

Identifying The Origins Of Business’ Data Breaches Utilizing Covert Timing Channels, Gayle L. Frisbie

Master's Theses and Doctoral Dissertations

Cybersecurity events and data breaches are on the rise and are very costly to businesses. Businesses rely on connectivity and information systems to conduct business, yet those same information systems can be breached and the organization's data exposed. Today, there is a heavy reliance of organizations upon network connections to connect the entire organization in order to conduct business efficiently and from multiple locations. Covert timing channels are a cybersecurity attack method in which malicious actors embed privileged information into normal network traffic without authorization. Malicious actors, by carefully manipulating timing patterns in covert timing channels, can create a hidden …

Effect Of Silicon Nano Particles Added To The Polymeric Coatings, Ramesh Chandra Tripathi

Master's Theses and Doctoral Dissertations

The purpose of this research was to compare mechanical and tribological properties of a coatingto the same coating with added nano silica. The sample coating for this project was bis-ureasil which was synthesized using 1:1 equivalent ratio of bis (3-trimethoxysilyl-propyl) amine (BTMSPA) (318.0g) and IPDI (52.0g) in 400g of anhydrous THF. The other coating was prepared by adding 10% nano silica particles. A scanning probe microscope was used to study the surface morphology of the coating samples, a Raman microscope was used to study the silicon concentration on and underneath the surface of the coating, and nano-indentation was used to …

School Leaders Creating An Inclusive School Culture For Students With Exceptionalities, Dawn Spears

Master's Theses and Doctoral Dissertations

Studies indicate that principals who create an inclusive culture and champion students with exceptionalities work towards success for all students. When students with exceptionalities spend time in the general education setting, they experience academic, social, and emotional growth. This study contributes to research on inclusive school leadership for students with exceptionalities to enhance capacity for inclusion and provide strategies around initiatives that foster inclusive school cultures. The research used a sequential mixed method multiple case study. Emotional intelligence, leadership styles, and leadership practices were examined for elementary school principals in urban and rural schools. The Emotional and Social Competency Inventory …

Assessment Of The Ecological Integrity Of Two Wetland Sites Within Eastern Michigan University’S Fish Lake Environmental Education Center (Fleec), Brianna Rice

Master's Theses and Doctoral Dissertations

Wetland ecosystems function as reservoirs of biodiversity for both terrestrial and aquatic organisms, and are among the most vulnerable ecosystems to degradation. The ecological integrity of two wetlands at Eastern Michigan University’s Fish Lake Environmental Education Center, a bog and one vernal pool, was assessed. Plant species richness was used to conduct Floristic Quality Assessments (FQA) using the coefficient of conservatism and wetland indicator status for each species. The Michigan Rapid Assessment Method (MiRAM) was conducted as a more comprehensive assessment of each ecosystem. The bog had an FQA of 31.6 and a MiRAM: 81/100, representing high-quality wetland conditions. The …

Towards A Transparency-Based, Value-Sensitive Design Solution For Bias In Self-Driving Cars: An Ethical Violation Assessment And Risk Analysis Framework On Consumer-Held Values, Nada Ahmad Madkour

Master's Theses and Doctoral Dissertations

Background: The rapid growth of automated systems and artificial intelligence (AI), particularly, self-driving cars (SDCs), has attracted significant investments and can potentially contribute to humanity’s flourishing. However, before widespread adoption, it is important to address ethical violations such as bias in AI, highlighted by many real-world cases of bias in AI leading to unfair outcomes in tools like facial recognition, hiring software, and pedestrian detection. Bias in AI can lead to potentially fatal outcomes in SDCs, emphasizing the need for a thorough examination of bias in SDCs.

Purpose: To enhance AI ethics by providing tools to support transparency and value- …

Automatic Modeling Of Cyber Intrusions Using The Diamond Model Utilizing Security Logs And Events, Mahmoud Al-Maani

Master's Theses and Doctoral Dissertations

Current intrusion analysis models suffer from unreliability and inaccuracy due to their reliance on outdated and inadequate data sources. Numerous models focus on a particular type of data, leading to potential modeling faults in intrusion analysis models' recommendations. The objective of this thesis is to build a modernized model by integrating the diamond model with security information and event management systems. This thesis presents a detailed cyber intrusion analysis model; in which Elasticsearch is being used to collect and analyze logs about cyber attacks and extract major indicators of compromise then finally map them to the diamond model. The results …

Formation Rates Of Silver Metal Danoprisms As A Function Of Halide Concentration, Steven Akins

Master's Theses and Doctoral Dissertations

anosystem morphology control is proving to be vital for developing nano technologies. This control allows for the optimization of a nanoparticle’s optical and electrical properties. One form of control is the addition of defects during nanocrystal formation. Nanoprisms are highly responsive to this form of control through halide concentration. However, the rate at which this control occurs has remained relatively unexplored. The formation kinetics of silver nanoprisms were monitored before, during, and after crystal formation as a function of halide concentration. The standard deviations between multiple replicates were found to be too large for this method to reach conclusions about …

The Impact Of Performance Based Funding On Institutional Financial Priorities In Public Two-Year And Four-Year Institutions, Ebony T. Spearman

Master's Theses and Doctoral Dissertations

This dissertation examines the impact of performance-based funding (PBF) policies on institutional financial priorities at 2-and 4-year colleges and universities. PBF is a policy mechanism used by states to incentivize higher education institutions to achieve specific performance outcomes, such as increased graduation and retention rates, by tying a portion of institutional funding to these outcomes. This research aims to determine the efficacy of PBF policies on institutional change and outcomes. More specifically, this research seeks to find the extent to which colleges and universities subjected to PBF policies change their financial priorities and how, if at all, these changes impact …

Atg11 And Atg9 Interaction In Selective Autophagy, Chimi Dolker Sherpa

Master's Theses and Doctoral Dissertations

Selective autophagy, induced by cellular stresses, degrades/recycles a specific cargo. Ithelps prevent diseases like Parkinson’s, Huntington's, cancer, and bacterial infections. It involves the formation of an autophagosome, a double-membrane vesicle that takes the cargo to the vacuole/lysosome for degradation. Atg11, the central organizer of selective autophagy, acts as a scaffold protein, interacting with Atg9, Atg1 and other Atg proteins. Our research focuses on finding mutations in Atg11 that specifically disrupt its interaction with Atg9 without affecting its dimerization or interaction with Atg1. We targeted residues 455-535 of Atg11 as a putative Atg9 interaction site, performing mutagenesis on four key residues …