Digital Commons Network^™

Reducing Broad-Spectrum Antibiotic Use By Appropriately Treating Community Acquired Pneumonia, Caleb I. Nieves-Velez, Richard Pieri, Miki Otta

Central & West Texas GME Research Day 2024

No abstract provided.

A Case Report On Syphilitic Lymphadenitis, Kelly Davis, Ryan Spilman, Alexander Enurah

Continental, MidAmerica, & Mountain Divisions GME Research Day 2024

No abstract provided.

An Atypical Presentation Of Tuberculoid Leprosy On The Heel, Clara Barranco, Karthik Krishnamurthy, Angelia Stepien

South Atlantic Division GME Research Day 2024

No abstract provided.

Pancytopenia And Disseminated Varicella-Zoster Virus In A Patient With T-Cell Lymphoblastic Lymphoma In Maintenance Phase Of Treatment: A Case Report, Kathryn Jordan, Paul Bryant, Clinton Carroll, Jennifer Domm

TriStar Division GME Research Day 2024

No abstract provided.

Eliding Consent In The Case Of Pandemic Countermeasures Authorized Only For Emergency Use, Lars Noah

UF Law Faculty Publications

Four months after the first vaccines against Covid-19 became available to the public, and just as some universities announced plans to require inoculations, the Boston Globe quoted me as (alone) suggesting that mandates would conflict with federal law. When Congress created a special mechanism for the emergency use of still investigational products, it directed providers to reveal, among other things, that individuals remained free to decline such an intervention; only after full FDA approval of a medical countermeasure would this disclosure obligation become inapplicable. I have watched with dismay over the last three years as nearly everyone—including Executive branch officials, …

Does Federal Preemption Inoculate Us Against The Alarming Prospect Of State Vaccine Bans?, Lars Noah

UF Law Faculty Publications

With growing resistance to vaccinations-premised, for instance, on misplaced fears of side effects or religious objections-it takes little effort to imagine that a state might act to prohibit some or all uses of a particular vaccine licensed by the federal government. Indeed, one year ago, legislators in a couple of states toyed with the idea of banning the primary vaccines against Covid-19, and, twenty years ago, half a dozen states effectively barred certain uses of one flu vaccine formulation. Although federal law should preempt at least some of these types of state restrictions, the Supremacy Clause of the U.S. Constitution …

Ivermectin Mda For Malaria Control And Plasmodium Species Diversity In Burkina Faso, Julia Ellman

Public Health Theses

Malaria is a major cause of mortality globally, but particularly in Africa and among children. As the growth of drug resistance threatens current malaria control and treatment strategies, novel interventions are needed to combat the recent increase in cases. Ivermectin is an endectocide that has been historically used to treat neglected tropical parasitic diseases through mass drug administration (MDA). Recently, it has been demonstrated to have a lethal effect on mosquitos, suggesting its potential as a valuable vector control strategy. RIMDAMAL II is a cluster randomized control trial that was conducted in southwestern Burkina Faso in 2019-2020 to evaluate the …

County-Level Factors Associated With School-Required Immunization Rates Among Connecticut Kindergarteners: 2018-2023, Carolyn Savananh Henry

Public Health Theses

The COVID-19 pandemic brought public attention to the implications of anti-vaccine sentiment to population health. However, the anti-vaccine movement began impacting school-aged children long before the pandemic. This study examines the role of socioeconomic factors in Connecticut kindergarten immunization rates between the 2018-2018 and 2022-2023 school years. Connecticut is the third smallest state in the United States, yet significantly diverse socioeconomic statuses exist within its small spatial boundary.

Analyzing data from the Connecticut Annual School Immunization Survey and the United States Census, we demonstrate a connection between socioeconomic factors and kindergarteners fully up-to-date on all required school immunizations at the …

Hemin As A Contributor To Inflammation In Sickle Cell Disease, Sarah Hinderstein

Public Health Theses

Background: Sickle Cell Disease (SCD) is the most common genetic hematological disorder and puts individuals at increased risk of morbidity and mortality due to infectious disease. Those with SCD also have a reduced capacity to mount successful vaccine responses compared to healthy individuals but there is an incomplete understanding of the mechanisms behind this.

Objectives: We aim to investigate the role of hemin as a potential contributor to inflammatory dysregulation and decreased vaccine immunogenicity in patients with SCD.

Methods: Peripheral blood mononuclear cells (PBMC) were isolated from patients with SCD aged 7-22 and healthy participants aged 22-30. We utilized flow …

Chad's Infectious Disease Surveillance In Context: An Analysis Of 2014-2023 Case Report Data, Sophie Licostie

Public Health Theses

Background: Infectious diseases remain a leading cause of mortality and morbidity in Chad. We aimed to assess trends in the most recent ten years of surveillance data collected by the Ministry of Public Health in Chad to characterize the country’s current disease burden.

Methods: In this analysis of Chadian surveillance data, we analyzed reports of suspected cases across seven diseases from 2014-2023. Data included weekly aggregated case counts by district. We used the data to describe temporal and spatial trends, particularly from 2014-2019 compared to 2020-2023.

Findings: Measles case counts showed seasonal peaks of varying intensity throughout most of 2014-2023. …

2024-2025 Maine Medical Center House Staff, Maine Medical Center

Graduate Medical Education

No abstract provided.

Informing A Care Plan For Hepatitis C Treatment On The Street, Claire Campbell

Scripps Senior Theses

This thesis aims to use community knowledge to inform clinical street treatment of Hepatitis C and to unpack the intersections of social systems within the realms of Street Medicine and healthcare for the unsheltered unhoused population. During the summer of 2023, 15 qualitative interviews were conducted with patients of the USC Keck School of Medicine Department of Street Medicine who received treatment for Hepatitis C infections. Using grounded theory analysis, participant responses were analyzed to identify key concepts and ideas from interview transcripts. Core themes fell into the following categories: how treatment affected patients’ lives, facilitators and barriers to treatment, …

Assessing Lipid Composition Of Cell Membrane In Escherichia Coli Under Aerobic And Anaerobic Conditions, Isabelle Johnson

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Escherichia coli is a highly studied model organism that is tightly tied to the mammalian gastrointestinal system. This microorganism has the capability to be a beneficial gut microbe or a life-threatening pathogen. In this study, the lipid membrane of Escherichia coli was investigated using Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) to observe the change in its composition in aerobic and anaerobic conditions. Evidence of desaturation was discovered in the spectra, though more investigation is needed to understand the metabolic processes and drives that result in this change. Elucidation of these pathways in the future could result in …

Compassionless Plea Bargaining, Julian A. Cook Iii

UF Law Faculty Publications

Too often, the guilty plea hearing process practiced in our federal courts fails to adequately ensure the validity of a defendant’s change of plea decision. Rather than engage in colloquies that are sufficiently in-depth and truly aimed at ascertaining voluntariness and defendant comprehension, critical details are frequently glossed over, and defendant guilty pleas are accepted without meaningful inquiry.

While academics have skillfully critiqued the Sixth Amendment and its trial-focused provisions, comparatively scant focus has been expended on the equally, if not more, critical change of plea hearing. Compassionless Plea Bargaining seeks to fill this gap with its focus on a …

Protecting Electronic Health Records After Dobbs, Francis, Leslie P.

Santa Clara Law Review

In the aftermath of Dobbs, states are taking dueling approaches to abortion prohibitions. Some states are enacting draconian criminal penalties for abortion providers or those helping patients seeking abortion services. Other states are doing all they can to protect patients receiving services within their borders and those who help them. Medical records are at the heart of these conflicts as they provide the best evidence of the patient’s condition and care provided. This article assesses the likely efficacy of state efforts to protect information in electronic health records from use in prosecutions or suits for damages in abortion restrictive states. …

Ce 653 Syllabus: Theory & Practice Of Sexual, Substance Abuse And Crisis Counseling, Mary Fawcett

Counselor Education Syllabi

This course is designed to assist mental health counselors in designing client-centered, individualized, and culturally sound treatment plans for a wide variety of clinical mental health disorders. Course content will include a strong focus on the diagnosis of mental health disorders based on criteria from the DSM-5, and the subsequent treatment planning and provision of evidence based clinical care.

Delineating Contributions Of Genotype And Lineage To Lung Cancer Therapy Response, Kassandra Jo Naughton

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) heterogeneity is a major challenge for determining effective treatment strategies. Adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) are histologically and epigenetically distinct subtypes of NSCLC. Patients with ADC tumors harboring mutations in both KRAS and LKB1 (aka STK11) have lower survival rates than those with KRAS-only tumors. KRAS/LKB1 tumors are not only aggressive, but also respond poorly to immunotherapy. However, these data are limited to ADCs, and it is unclear if SCCs with this genotype are also resistant to immunotherapy. We developed a mouse model of Kras^mut/Lkb1^mut capable of producing …

Impact Of Administrative Support On Staff Mental Health, Crystal L. Capps

Doctor of Education Dissertations

The purpose of this mixed methods study was to examine the impact of administrative support on staff mental health. Research questions were created for this research study and were investigated throughout its design and implementation. This research study involved participation from three district-approved schools: one elementary, one middle, and one high school in eastern North Carolina. Two surveys were designed, one for educators and one for administrators. Once the research was completed, the data were analyzed for key themes regarding how mental health affects educators in the classroom. Themes were identified to determine the impact of administrative support on staff …

Study Of Antibiotics Resistance And Biofilm Formation Of Staphylococcus Aureus, Lamyaa Khalid Muhammed, Ali Jaffar Saleem

Al-Nisour Journal for Medical Sciences

The aim of this study is to assess the biofilm-production rates in clinical S. aureus isolates and to correlate between multidrug resistance and their biofilm-forming capacity. One hundred ninety (190) clinical specimens were collected from different clinical sources (wounds, burns, urine, ear and blood) in Diyala province, during the period from September 15/ 2022 to December 15/ 2022. The isolates were diagnosed morphologically, microscopically, biochemically and confirmed by 16SrRNA detection. All isolates were investigated for antibiotic sensitivity, using the disc diffusion method. The isolates under test showed a high resistance 100% to OX, while the rates of resistance ranged from …

Early Identification Of Covid-19 Patients Using Hematological Profile And Biochemical Parameters, Zahra'a Abdul Al-Aziz Yousif, Jabbar S. Hassan, Ghaith Hamid Hameed

Al-Nisour Journal for Medical Sciences

COVID-19 patients showed changes in biochemical and hematological parameters which may cause other complications. D-dimer is one of the prognostic biomarkers used to predict COVID-19 infection, the elevated level of it considered one of the risk factors for mortality especially in adult COVID-19 patients and indicated the positive correlation between D-dimer and disease severity. Another biochemical biomarker is ferritin and CRP, which consider a key mediators of the immune dysregulation via direct immune suppressive and contributing to cytokine storm. This suggested the ferritin and CRP level might be considered a crucial factor influencing the severity of COVID-19. SARS-COV-2 also has …

Optimizing Ventilator-Associated Pneumonia Prevention And Education: In Adult Icu Settings, Danielle Gonzalez

Nursing | Senior Theses

Background: Ventilator associated pneumonia (VAP) in adult intensive care patient units (ICU) is one of the most common and deadly nosocomial infections today. Studies have identified a gap in intensive care nurse ventilator education and compliance with hospital protocols. Overall increasing the rates of VAP and morbidity. Hospitals worldwide have shown a decrease in VAP rates after inheriting "VAP-bundles''. This includes nurse specific interventions and assessments as a preventative measure. However, studies failed to demonstrate which bundle interventions directly correspond to the prevention of VAP. Purpose: Address all components of education, a nurse’s ability to properly identify and understand the …

Traditional Chinese Medicine And Modern Medicine, Ascher Shostak

Inquiro (undergraduate research journal)

pp. 20-23

https://www.uab.edu/inquiro/issues/current-issue/traditional-chinese-medicine-and-modern-medicine

Food And Drug Regulation: Statutory And Regulatory Supplement (2024), Adam I. Muchmore

Faculty Scholarship

This Statutory and Regulatory Supplement is intended for use with its companion casebook, Food and Drug Regulation: A Statutory Approach (2021). This is not a traditional statutory supplement. Instead, it contains selected, aggressively edited provisions of the Federal Food, Drug and Cosmetic Act (FFDCA), related statutes, and the Code of Federal Regulations. The Supplement includes all provisions assigned as reading in the casebook, as well as a few additional provisions that some professors may wish to cover. The excerpts are designed to be teachable rather than comprehensive.

To Speak Or Not To Speak: Institutional And Presidential Statements In Response To Community Crisis Events, Kimberly L. Caponi

Dissertations of Practice

To Speak or Not to Speak: Institutional and Presidential Statements in Response to Community Crisis Events

Kimberly L. Caponi, Ed.D.

Department of Counseling and Higher Education

Northern Illinois University

Carrie Kortegast, Director

The purpose of this case study was to understand the decision-making process of community college leaders in issuing institutional responses to community crisis incidents. During 2020-2021, in addition to the global COVID-19 pandemic, there were several high-profile racialized incidents that sparked calls for action and a racial reckoning. The research explored the decision-making process and experience of leaders in response to the murder of George Floyd. Five themes …

Association Between Hematological Parameters And Severity Of Covid-19 Disease, Gokul Krishnan, Shubhada Karanth, Sudha Vidyasagar, Archit Aggarwal

Open Access archive

Background: This study aimed to determine the relationships between hematological parameters- hemoglobin, Total Leucocyte Counts (TLC), platelet counts, Absolute Neutrophil Counts (ANC), Absolute Lymphocyte Counts (ALC), Neutrophil Lymphocyte Ratio (NLR), Systemic Immune Inflammatory Index (SII), Neutrophil Monocyte Ratio (NMR), Platelet Lymphocyte Ratio (PLR) and the severity of COVID-19 disease and their use in predicting severity of COVID-19 disease. Methods and Material: This was a prospective, observational, single-center study of 573 symptomatic adult inpatients of COVID 19 admitted to our tertiary care center. Statistical analysis used: The above-mentioned hematological parameter levels were noted and compared between the two categories of COVID-19 …

Efficacy Of Lycium Barbarum (Goji Berry) Mouthwash For Managing Periodontitis: A Randomized Clinical Trial, Amee Sanghavi, Laasya Shettigar, Aditi Chopra, Ashmeet Shah

Open Access archive

Background: Removal of the microbial deposits (plaque and calculus) by performing effective scaling and root planing (SRP) is the fundamental step for managing periodontal disease (gingivitis and periodontitis). Various adjuncts in the form of mouthwash, gels, and toothpaste are also being used as adjuncts to SRP for managing periodontitis. Recently, Lycium barbarum (L. barbarum), commonly known as goji berry or wolfberry, has gained popularity for managing chronic inflammatory and infectious diseases. However, its efficacy in managing periodontitis has never been explored. Hence the present study aims to evaluate the efficacy of goji berry mouthwash compared to chlorhexidine mouthwash for managing …

Development Of Levofloxacin Glycosylated Mesoporous Silica Nanoparticles For Urinary Tract Infections, Songhita Mukhopadhyay, Reema Narayan, Shivaprasad Gadag, Padmaja A. Shenoy

Open Access archive

Nanoparticle drug delivery for infectious disease has paved the way for effective treatment; mesoporous silica nanoparticles (MSNs) with versatile design options, tunable pore size, high surface area, and adequate pore volume have garnered widespread interest. The current study deals with the synthesis of MSNs loaded with levofloxacin (LVF), followed by glycosylation to enhance the uptake by bacterial cells. The MSNs were prepared by modifying Stober’s process. The amino-modified MSNs were glycosylated using D-Glucuronic acid by EDAC-NHS coupling chemistry. The LVF -loaded glycosylated MSNs (GLY-MSN) were characterized for various parameters and in vitro antimicrobial efficacy study. The surface functionalized MSNs had …

Pass: A Scoring System To Evaluate Persistent Kidney Injury In Critically Ill Icu Adult Patients, Dattatray Prabhu, Sonali Dattatray Prabhu, Chakrapani Mahabala, Mayoor V. Prabhu

Open Access archive

Background: We evaluated if the course of recovery from sepsis-induced acute kidney injury (AKI) can be predicted using variables collected at admission. Methods: A total of 63 patients admitted for sepsis-induced AKI in our Mangalore ICU were evaluated and baseline demographic and clinical/laboratory parameters, including serum creatinine (SCr), base excess (BE), Plethysmographic Variability Index (PVI), Caval Index, R wave variability index (RVI), mean arterial pressure (MAP) and renal resistivity index (RI) using renal doppler and need for inotropes were assessed on admission. Patients were managed as per standard protocol. After six hours of fluid resuscitation, patients were classified as volume …

Concepts In Animal Parasitology, Chapter 39: Haplosplanchnata Olson Et Al., 2003 (Suborder): Two Hosts With Half The Guts [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Daniel C. Huston

Concepts in Animal Parasitology

An overview of the suborder Haplosplanchnata Olson et al., 2003, a small, but distinct lineage within the Plagiorchiida. Includes a discussion of the methods of identification, general morphological characteristics, taxonomy, and life cycles.

Chapter 39 in Concepts in Animal Parasitology, by Daniel C. Huston. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap039

Concepts In Animal Parasitology, Chapter 47: Summary Of The Digenea (Subclass): Insights And Lessons From A Prominent Parasitologist [Platyhelminthes, Trematoda, Digenea], Robin M. Overstreet

Concepts in Animal Parasitology

An overview of the digenean trematodes (subclass Digenea) including insights and lessons from a prominent parasitologist, Robin M. Overstreet. Includes discussion of general morphology, biology, preparation methods, phylogeny, classification, life cycles, host-digenean relationships, effects on host behavior, hyperparasitism, ecology, digeneans as indicators, and literature on the digeneans.

Chapter 47 in Concepts in Animal Parasitology, by Robin M. Overstreet. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap047