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High Prevalence Of Trypanosoma Cruzi Infection In Raccoons (Procyon Lotor) And Associated Risk To Humans In Central Illinois, Esther Onuselogu

Masters Theses

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a neglected tropical disease and a growing health threat in the United States. Raccoons (Procyon lotor) often coexist with humans in urban and suburban areas and serve as reservoir hosts for T. cruzi. While T. cruzi is rare in humans and domestic animals in the U.S., it is common in wildlife species, particularly raccoons and Virginia opossums (Didelphis virginiana). This study aimed to assess the prevalence of T. cruzi infection in the raccoon population of Central Illinois and evaluate the risk of transmission to humans. …

Sphingosine Kinase 2 Depletion Dysregulates Hepatic Redox Metabolism And Enhances Inflammation In Early Metabolic Dysfunction-Associated Steatohepatitis (Mash), Kaitlyn Georgene Jackson

Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects one in three people worldwide; its prevalence is growing alongside other cardiometabolic disorders. Aberrations to redox and sphingolipid metabolism contribute to MASLD pathologic progression. Sphingosine-1-phosphate (S1P) is an active lipid, meaning that S1P participates in biochemical processes within the cell. S1P is generated by two distinct isoenzymes, sphingosine kinase (SphK)1 and SphK2. The localization of the SphK enzyme dictates S1P function. While cytosolic SphK1-generated S1P is well-characterized, nuclear and mitochondrial SphK2-generated S1P is less known. Moreover, SphK2 depletion effects on cellular redox processes and inflammation are not well-defined.

This study defines the …

The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner

Theses and Dissertations

Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …

Evaluating The Performance Of Flukecatcher At Detecting Urogenital Schistosomiasis, Louis Fok, Berhanu Erko, David Brett-Major, Abebe Animut, M. Jana Broadhurst, Daisy Dai, John Linville, Bruno Levecke, Yohannes Negash, Abraham Degarege

Journal Articles: Epidemiology

Urine filtration microscopy (UFM) lacks sensitivity in detecting low-intensity Schistosoma haematobium infections. In pursuit of a superior alternative, this study evaluated the performance of FlukeCatcher microscopy (FCM) at detecting S. haematobium eggs in human urine samples. Urine samples were collected from 572 school-age children in Afar, Ethiopia in July 2023 and examined using UFM and FCM approaches. Using the combined UFM and FCM results as a reference, the sensitivity, negative predictive value, and agreement levels for the two testing methods in detecting S. haematobium eggs in urine samples were calculated. The sensitivity and negative predictive value of detecting S. haematobium …

Antibiotics Misuse And Antimicrobial Resistance Development In Agriculture: A Global Challenge, Baljit Singh, Abhijnan Bhat, Kamna Ravi

Articles

No abstract provided.

Eskape: Navigating The Global Battlefield For Antimicrobial Resistance And Defense In Hospitals, Kamna Ravi, Baljit Singh

Articles

The current healthcare environment is at risk due to the facilitated transmission and empowerment of the ESKAPE pathogens, comprising of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. These pathogens have posed significant challenges to global public health and the threat has only amplified over time. These multidrug-resistant bacteria have become adept at escaping the effects of conventional antibiotics utilized, leading to severe healthcare-associated infections and compromising immunocompromised patient outcomes to a greater extent. The impact of ESKAPE pathogens is evident in the rapidly rising rates of treatment failures, increased mortality, and elevated healthcare costs. …

Covid-19 Pediatric Vaccine Authorization, Fda Authority, And Individual Misperception Of Risk, Joanna K. Sax, Neal Doran

Faculty Scholarship

Vaccines are one component to the public health strategies to alleviate the COVID-19 pandemic. Hesitancy regarding COVID-19 vaccines in the United States has been problematic, which is not surprising given increasing overall vaccine hesitancy in recent decades. Most vaccines are administered during childhood years. Consequently, understanding hesitancy toward administration of vaccines in this age group may provide insight into possible interventions to reduce vaccine hesitancy. The present study analyzed a subset of over 130,000 public comments posted in response to a notice of meeting of the vaccine advisory group to the Food and Drug Administration. The meeting addressed whether to …

Understanding Covid-19 Booster Hesitancy Amongst Those Experiencing Homelessness And Housing Instability, Kelsey Bas

Global Public Health | Student Research Posters

The COVID-19 vaccine had an efficacy of 80-90% against symptomatic and asymptomatic COVID-19 infections in those who have completed the primary series of the vaccine. The booster vaccine restored infection protection with an efficacy of 75-85%.

California marks the highest rate of homelessness in the nation which was influenced by the pandemic. The COVID-19 pandemic also caused 17 million Californians (44%) who live in rented homes to be at risk for eviction moratoriums and rental assistance. Those experiencing homelessness and housing instability are at higher risk of contracting severe COVID-19 due to prior medical conditions, poor health status, and lack …

Root Causes Of Homelessness In Marin County And Prevention Strategies, Michaela George, Kelsey Bas, Joe Blakely, Naila Saghir, Garrett Siebels, Liliana Valle-Contreras, Sehrish Khan

Global Public Health | Student Research Posters

Even with increased prevalence of homelessness in the US, there is limited research that investigates circumstances that can lead to homelessness. This lack of understanding perpetuates the inequities in health and wellbeing, access to basic necessities, effective prevention strategies and meaningful policy changes.

More individuals are experiencing homelessness in California than ever before In Marin, the Ritter Center (RC) strives to prevent and resolve homelessness and improve the health and well-being of individuals living in poverty

Vaccine Hesitancy In Those Experiencing Homelessness And Housing Instability In Marin County: Is Covid-19 Any Different?, Kelsey Bas

Global Public Health | Senior Theses

Introduction:

COVID-19 booster hesitancy amongst different populations is a continuing public health issue. Within Marin County, individuals experiencing homelessness or housing instability are not receiving their booster vaccination in spite of receiving the primary series of the COVID-19 vaccine. Hence, there is a lack of research that reveals the barriers and motivation as to why individuals experiencing homelessness and housing instability in Marin are facing hesitancy towards the COVID-19 booster.

Methods:

In this qualitative study, the researcher interviewed clients of the Ritter Center. Semi-structured interviews were conducted with individuals ages 18 and older, currently experiencing homelessness or housing instability, and …

Unveiling The Complex World Of Extracellular Vesicles: Novel Characterization Techniques And Manufacturing Considerations, James J Lai, John J Hill, Casey Y Huang, Gino C Lee, Karol W Mai, Maggie Y Shen, Simon K Wang

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) function as potent mediators of intercellular communication for many in vivo processes, contributing to both health and disease related conditions. Given their biological origins and diverse functionality from correspondingly unique "cargo" compositions, both endogenous and modified EVs are garnering attention as promising therapeutic modalities and vehicles for targeted therapeutic delivery applications. Their diversity in composition, however, has revealed a significant need for more comprehensive analytical-based characterization methods, and manufacturing processes that are consistent and scalable. In this review, we explore the dynamic landscape of EV research and development efforts, ranging from novel isolation approaches, to their analytical …

Increasing Pneumonia Vaccine Uptake At A Family Medical Practice In Saint Petersburg, Florida, Nicholas Potnis

Doctor of Nursing Practice (DNP)

Pneumonia is the leading cause of infectious mortality in the United States. Each year over 100,000 people die from this disease nationally, with over 6,000,000 deaths worldwide. Both young and old are at risk of infection. The Centers for Disease Control and Prevention (CDC) provides guidance on vaccine administration and candidacy. This clinical practice change project sought to increase pneumococcal vaccination rates at an urban family health practice. Nola Pender's Health Promotion Model was used as the guiding nursing theory for this DNP project This was accomplished by assessing patients’ level of vaccine hesitancy and provider-led conversations to overcome vaccine …

A Case Study In Program Evaluation: A Prospective Program Evaluation Of Timely Reporting And Action Of An Infectious Disease Outbreak, Destiny Cozart

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Methicillin-resistant Staphylococcus aureus also known as MRSA is an infection of a staph bacteria. High school athletes are at risk of contracting MRSA through skin to skin contact and/or MRSA contaminated equipment. This case study uses the CDC's six-step framework for program evaluation to measure the effectiveness of the online training modules designed to increase the knowledge of staff and stakeholders about MRSA and infectious disease outbreaks. The findings from this evaluation will advise the potential change(s) implemented in training modules, ultimately to enhance competency for decision makers and prevent MRSA and infectious disease outbreak amongst high school athletic programs.

Prevalence Of Hpv16 E6 Antibodies And Oral Hpv Among Men Living In Kentucky, Christopher O. Otieno

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

ABSTRACT

Objective: The incidence of human papillomavirus-driven oropharyngeal cancer (HPV-OPC) is surging in the United States, particularly in the southeast and Appalachia. The reason for this increase is unknown. We evaluated the prevalence of two markers of increased risk, HPV16 E6 antibodies and oral HPV infection, among men in Appalachian and non-Appalachian Kentucky.

Methods: This study was nested within an ongoing HPV-OPC screening study of healthy men aged 45+ residing in urban (non-Appalachian) and rural (Appalachian) Kentucky and included the first 1,581 participants with either HPV serologic and/or oral HPV testing. Blood and oral rinse samples were collected at enrollment. …

Fall 2023 Covid-19, Influenza, And Respiratory Syncytial Virus Vaccine Uptake In Kentucky, Abigail Dial

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Fall 2023 COVID-19, Influenza, and Respiratory Syncytial Virus Vaccine Uptake in Kentucky

Background: In the fall of 2023, vaccine recommendations included updated COVID-19 and influenza vaccines, as well as a new vaccine and immunization for respiratory syncytial virus (RSV). Vaccine co-administration, the administration of more than one vaccine in one vaccination session, is safe and effective for COVID-19, influenza, and RSV vaccines and can improve vaccine uptake for all recommended vaccines (Bonanni, et al., 2023; CDC, 2023). The COVID-19 pandemic altered the landscape for locations where people receive vaccinations, and it may be beneficial to public health to have …

Spop Downregulation Promotes Bladder Cancer Progression Based On Cancer Cell-Macrophage Crosstalk Via Stat3/Ccl2/Il-6 Axis And Is Regulated By Vezf1., Meiqian Li, Yangyan Cui, Qi Qi, Jiakuan Liu, Jiaxuan Li, Guifang Huang, Jiale Yang, Jingya Sun, Zhihui Ma, Shengjie Liang, Dianzheng Zhang, Jun Jiang, Rujian Zhu, Qiuli Liu, Ruimin Huang, Jun Yan

PCOM Scholarly Works

Background: Cancer cells are intimately intertwined with tumor microenvironment (TME), fostering a symbiotic relationship propelling cancer progression. However, the interaction between cancer cells and tumor-associated macrophages (TAMs) in urothelial bladder cancer (UBC) remains poorly understood. Methods: UBC cell lines (5637, T24 and SW780), along with a monocytic cell line (U937) capable of differentiating into macrophage, were used in a co-culture system for cell proliferation and stemness by MTT, sphere formation assays. VEZF1/SPOP/STAT3/CCL2/ IL-6 axis was determined by luciferase reporter, ChIP, RNA-seq, co-IP, in vitro ubiquitination, RT-qPCR array and ELISA analyses. Results: We observed the frequent downregulation of SPOP, an E3 …

Leveraging Google Trends To Nowcast Covid-19 Epidemics: A Proposed Methodology, Kush Raj Shanker

Public Health Theses

The outbreak of the SARS-CoV-2 pandemic in 2019 has emphasized the need for accurate and timely estimation of infectious disease cases. An important aspect of controlling infectious diseases is the development of robust nowcasting methods, which involve estimating the current and near-future state of an epidemic using real-time data. Google Trends (GT) has emerged as a valuable tool in epidemiology, allowing researchers to track and predict disease outbreaks by analyzing patterns in internet users' searches. While GT provides real-time information on search queries related to infectious disease symptoms and treatment, it has limitations such as data reliability, privacy concerns, sampling …

The Lavatory Lens: Tracking The Global Movement Of Pathogens Via Aircraft Wastewater, Aaron Bivins, Robert Morfino, Andrew Franklin, Stuart Simpson, Warish Ahmed

Faculty Publications

Modern commercial air travel connects disparate human populations. The global airline industry transported as many as 4.5 billion passengers annually in the years leading up to the COVID-19 pandemic. While such connections are convenient for commerce and tourism, air travel networks can also be efficient distributors of infectious diseases. During the COVID-19 pandemic, public health agencies used multi-layered control strategies to manage the risk of COVID-19 transmission associated with air travel. Simultaneously, the surveillance of aircraft wastewater was further developed as a promising new method to screen for COVID-19, including newly emerging lineages, among international travelers. Herein, we review the …

Editorial: How Rsv Outsmarts The Host, Stephania A. Cormier, Lawrence M. Kauvar, Ralph A. Tripp

Division of Basic Science Faculty Publications

No abstract provided.

Exploring Older Adults’ Mobility Challenges And Preferences Before And After Experiencing Covid-19 Pandemic, Hany Hassan, Bernard Boakye

Publications

The US Census Bureau reports that the number of seniors (65+ years old) in the US is predicted to increase from 16.5% in 2019 to 22% by 2050. However, seniors have reduced mobility as they age due to their declining health and the limited travel options available. Therefore, it is crucial to solve their transportation needs during pandemics like COVID-19 when they are most disadvantaged. This study involved an online national survey that collected 1507 responses from seniors in all the 50 US states to examine their travel behavior and challenges and their willingness to adopt Autonomous Vehicles before and …

Are We Adequately Training Our Healthcare Providers Facing The Pandemic Of Obesity?, Eric Ravussin

Clinical Research Faculty Publications

No abstract provided.

Advancing Health Equity: The Role Of A Community–Academic–Public Health–Practice (Capp) Partnership In Addressing Covid-19 Disparities In Louisiana, John Mcclure, Lee Mendoza, Theresa Sokol, Davondra Brown, Thomas Laveist, Sandra Brown, Erin Peacock, La Keisha Williams, David Mushatt, Peter Katzmarzyk, Daniel Sarpong, Marie Krousel-Wood

Population and Public Health Science Faculty Publications

We assessed the impact of an innovative Louisiana community–academic–public health–practice (CAPP) partnership in addressing COVID-19–associated Black–White vaccination disparities over 19 months. Initially (April 2021), the cumulative vaccinations for Black versus White Louisianans were 54 542 per 100 000 versus 62 435 per 100 000, respectively. By October 2022, cumulative vaccinations for Black versus White Louisianans were 142 437 per 100 000 versus 132 488 per 100 000, respectively. The vaccination equity score increased from 908 out of 1000 in April 2021 to 942 out of 1000 in October 2022. CAPP partnership efforts contributed to addressing initial Black–White COVID-19 vaccination disparities. …

Updates In Air Pollution: Current Research And Future Challenges, Dwan Vilcins, Rebecca C. Christofferson, Jin Ho Yoon, Siti Nurshahida Nazli, Peter D. Sly, Stephania A. Cormier, Guofeng Shen

Division of Basic Science Faculty Publications

Background: The United Nations has declared that humans have a right to clean air. Despite this, many deaths and disability-adjusted life years are attributed to air pollution exposure each year. We face both challenges to air quality and opportunities to improve, but several areas need to be addressed with urgency. Objective: This paper summarises the recent research presented at the Pacific Basin Consortium for Environment and Health Symposium and focuses on three key areas of air pollution that are important to human health and require more research. Findings and conclusion: Indoor spaces are commonly places of exposure to poor air …

Inspire : Vol 7 Issue 1, Department Of Medicine

INSPIRE – Department of Medicine Archives

• Message from the Chair
• Medicine at National and International Forums
• AKUPI-NCD Symposium "A Dialogue on NCDs"| A Triumph in Health Discourse By Zeerak Jarra
• Department of Medicine Appreciation Evening 2023
• AKU Dermatology on International Fronts
• Developing Healthcare Leaders for Tomorrow
• Poem Section
• What Academics Are Reading
• Upcoming Events

Better Together: Building Community In The Lrw Classroom, Olympia Duhart

Saint Louis University Law Journal

Better Together: Building Community in the LRW Classroom emphasizes the importance of building a strong community within the Legal Research and Writing (“LRW”) classroom. A robust LRW community helps mitigate the stress associated with the course and equips students to manage the rigorous demands of law school. Given the challenges facing today’s law students and the unique challenges that characterize LRW, developing community in the LRW classroom should be a primary focus of effective law school training. This Article highlights the work of Thomas Hawk and Paul Lyons, who have studied the concept of “pedagogical caring” in higher education. The …

Bridging The Gap In Health Literacy: A Quality Improvement Project, Sunny Rana

DNP Projects

Background: Health literacy is an important factor for healthcare outcomes. Measuring healthcare outcomes continues to be traditionally performed after implementation of interventions, however, the aspect of healthcare literacy pertaining to these outcomes is not always measured or evaluated. Understanding the patient’s health literacy can assist the provider to create and include individualized education at the patient’s knowledge level to increase comprehension, compliance, medication adherence and ultimately increase positive health outcomes.

Project Goals

1. Assess baseline literacy for the patients who appear in the practice for a visit over a three-month period.

2. Implementing the measurable METER tool which can provide …

Rapid Increase Of Female But Not Male Obesity: Analysis Of The 2023 Vanuatu Health Transition Project Survey On Aneityum, Matthew Christian, Olivia Lasalle, Zhiqiao Huang, Ricky Chen, Hannah Chen

Research Days Posters 2024

Developing nations are undergoing a health transition alongside rapid economic modernization. Vanuatu is experiencing such a transition marked by decreased cases of infectious disease and increased incidence of chronic and non-communicable diseases. Aneityum is a small island in Vanuatu and is behind more developed islands in its transition. This research sought to continue tracking the population health on Aneityum, analyze health differences between sexes, and compare findings to previous data in Vanuatu. In July and August of 2023, adult males [n=41] and females [n=62] were surveyed and had their anthropometric measurements taken. Mean anthropometric measurements continued to be significantly greater …

Effects Of Physical Activity Intervention On Reducing Neck And Upper Extremity Pain Intensity For Female Office Computer Workers, Peng Cheng Sung, Tiffany Chiu, Yunsen Wang

Department of Accounting and Finance Faculty Scholarship and Creative Works

The computer usage among office workers had increased tremendously in past recent years and the surge in computer usage has created a surge in work-related musculoskeletal disorders (WRMSDs) on arm, neck, and shoulder. For prevalence of musculoskeletal symptoms in relation to gender and age, females had higher risk and prevalence of upper limb complaints and the prevalence of WRMSDs generally increases with age. Systematic review studies had reported effectiveness of various physical activity (PA) interventions on improvements of upper extremity musculoskeletal disorders (UEMSDs) or neck pain for office workers. However, the degree of adherence of PA interventions with WHO guidelines …

Biodegradable Nanoparticles Targeting Circulating Immune Cells Reduce Central And Peripheral Sensitization To Alleviate Neuropathic Pain Following Spinal Cord Injury., Michael N. Saunders, Kate V. Griffin, Irina Kalashnikova, Daniel Kolpek, Dominique R. Smith, Eiji Saito, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea, Jonghyuck Park

Pharmaceutical Sciences Faculty Publications

Neuropathic pain is a critical source of comorbidity following spinal cord injury (SCI) that can be exacerbated by immune-mediated pathologies in the central and peripheral nervous systems. In this article, we investigate whether drug-free, biodegradable, poly(lactide- co -glycolide) (PLG) nanoparticle treatment mitigates the development of post-SCI neuropathic pain in female mice. Our results show that acute treatment with PLG nanoparticles following thoracic SCI significantly reduces tactile and cold hypersensitivity scores in a durable fashion. Nanoparticles primarily reduce peripheral immune-mediated mechanisms of neuropathic pain, including neuropathic pain-associated gene transcript frequency, transient receptor potential ankyrin 1 nociceptor expression, and MCP-1 (CCL2) chemokine …

The Genetic Diversity Of An Endangered Buttercup, Ranunculus Triternatus, Ryan Garcia

All Graduate Projects

Ranunculus triternatus, a rare endemic species of the Columbia River Gorge, faces conservation challenges due to its limited range and fragmented populations. This study assesses the genetic diversity of R. triternatus and compares it with its widespread congener, Ranunculus glaberrimus, using inter-primer binding site (iPBS) markers. Genetic data from 80 individuals across eight populations were analyzed using Nei’s genetic diversity, Shannon’s diversity index, and AMOVA. Results showed R. triternatus had higher genetic diversity than western populations of R. glaberrimus, with eastern populations of R. glaberrimus displaying greater diversity than western ones. PCA, UPGMA, and STRUCTURE analysis revealed …