Digital Commons Network^™

Catheter-Associated Urinary Tract Infections (Cautis) And The Relationship Between Hospital Overall Star Ratings And Reimbursement Rates, Cynthia Palmer

Walden Dissertations and Doctoral Studies

No abstract provided.

Relationship Of Weekly Rest To Bsn Appraisal Of Stress And Hardiness, Everly Batuik

Walden Dissertations and Doctoral Studies

No abstract provided.

The Narratives Of Participation In Restorative Justice Programs In Formerly Incarcerated African American Men, Jerry D. Elster

Walden Dissertations and Doctoral Studies

No abstract provided.

January 23, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Multivalent Epigraph Hemagglutinin Vaccine Protects Against Influenza B Virus In Mice, Erika M. Petro-Turnquist, Brigette Corder Kampfe, Amber Gadeken, Matthew J. Pekarek, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Influenza B virus is a respiratory pathogen that contributes to seasonal epidemics, accounts for approximately 25% of global influenza infections, and can induce severe disease in young children. While vaccination is the most commonly used method of preventing influenza infections, current vaccines only induce strain-specific responses and have suboptimal efficacy when mismatched from circulating strains. Further, two influenza B virus lineages have been described, B/Yamagatalike and B/Victoria-like, and the limited cross-reactivity between the two lineages provides an additional barrier in developing a universal influenza B virus vaccine. Here, we report a novel multivalent vaccine using computationally designed Epigraph hemagglutinin proteins …

Biochemical And Structural Analysis Of The Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (Dape) From Acinetobacter Baumannii, Emma H. Kelley, George Minasov, Katherine Konczak, Ludmilla Shuvalova, Joseph S. Brunzelle, Shantanu Shukla, Megan Beulke, Teerana Thabthimthong, Ken W. Olsen, Nicole L. Inniss, Karla Jf Satchell, Daniel P. Becker Ph.D.

Chemistry: Faculty Publications and Other Works

There is an urgent need for new antibiotics given the rise of antibiotic resistance, and succinyl-diaminopimelate desuccinylase (DapE, E.C. 3.5.1.18) has emerged as a promising bacterial enzyme target. DapE from Haemophilus influenzae (HiDapE) has been studied and inhibitors identified, but it is essential to explore DapE from different species to assess selective versus broad-spectrum therapeutics. We have determined the structure of DapE from the ESKAPE pathogen Acinetobacter baumannii (AbDapE) and studied inhibition by known inhibitors of HiDapE. AbDapE is inhibited by captopril and sulfate comparable to HiDapE, but AbDapE was not significantly …

Virology-The Path Forward, Angela L Rasmussen, Gigi K Gronvall, Anice C Lowen, Felicia Goodrum, James Alwine, Kristian G Andersen, Simon J Anthony, Joel Baines, Arinjay Banerjee, Andrew J Broadbent, Christopher B Brooke, Samuel K Campos, Patrizia Caposio, Arturo Casadevall, Gary C Chan, Anna R Cliffe, Donna Collins-Mcmillen, Nancy Connell, Blossom Damania, Matthew D Daugherty, Kari Debbink, Terence S Dermody, Daniel Dimaio, W Paul Duprex, Michael Emerman, Denise A Galloway, Robert F Garry, Stephen A Goldstein, Alexander L Greninger, Amy L Hartman, Brenda G Hogue, Stacy M Horner, Peter J Hotez, Jae U Jung, Jeremy P Kamil, Stephanie M Karst, Lou Laimins, Seema S Lakdawala, Igor Landais, Michael Letko, Brett Lindenbach, Shan-Lu Liu, Micah Luftig, Grant Mcfadden, Andrew Mehle, Juliet Morrison, Anne Moscona, Elke Mühlberger, Joshua Munger, Karl Münger, Eain Murphy, Christopher J Neufeldt, Janko Z Nikolich, Christine M O'Connor, Andrew Pekosz, Sallie R Permar, Julie K Pfeiffer, Saskia V Popescu, John G Purdy, Vincent R Racaniello, Charles M Rice, Jonathan A Runstadler, Martin J Sapp, Rona S Scott, Gregory A Smith, Erin M Sorrell, Emily Speranza, Daniel Streblow, Scott A Tibbetts, Zsolt Toth, Koenraad Van Doorslaer, Susan R Weiss, Elizabeth A White, Timothy M White, Christiane E Wobus, Michael Worobey, Satoko Yamaoka, Andrew Yurochko

Faculty, Staff and Students Publications

In the United States (US), biosafety and biosecurity oversight of research on viruses is being reappraised. Safety in virology research is paramount and oversight frameworks should be reviewed periodically. Changes should be made with care, however, to avoid impeding science that is essential for rapidly reducing and responding to pandemic threats as well as addressing more common challenges caused by infectious diseases. Decades of research uniquely positioned the US to be able to respond to the COVID-19 crisis with astounding speed, delivering life-saving vaccines within a year of identifying the virus. We should embolden and empower this strength, which is …

Exploring Factors For Implementation Of Epas In Pediatric Subspecialty Fellowships: A Qualitative Study Of Program Directors., Angela S. Czaja, Richard B. Mink, Bruce E. Herman, Pnina Weiss, David A. Turner, Megan L. Curran, Diane E J Stafford, Angela Myers, Melissa L. Langhan

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To understand fellowship program directors' (FPDs) perspectives on facilitators and barriers to using entrustable professional activities (EPAs) in pediatric subspecialty training.

METHODS: We performed a qualitative study of FPDs, balancing subspecialty, program size, geographic region and current uses of EPAs. A study coordinator conducted 1-on-1 interviews using a semistructured approach to explore EPA use or nonuse and factors supporting or preventing their use. Investigators independently coded transcribed interviews using an inductive approach and the constant comparative method. Group discussion informed code structure development and refinement. Iterative data collection and analysis continued until theoretical sufficiency was achieved, yielding a thematic …

Targeting Efferocytosis In Inflammaging, Ivan K H Poon, Kodi S Ravichandran

2020-Current year OA Pubs

Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors such as DNA and nuclear proteins from membrane permeabilized dying cells. Here, we review the molecular basis of the three key phases of efferocytosis, that is, the detection, uptake, and degradation of apoptotic materials by phagocytes. We also discuss how defects in efferocytosis due to the alteration of phagocytes and dying cells …

Building Research Capacity In Low- And Middle-Income Countries And Pandemic Preparedness: Lessons Learned And Future Directions, Peter H. Kilmarx, Karen A. Goralesk, Erum Khan, John F. Lindo, Nancy Gore Saravia

Department of Pathology and Laboratory Medicine

Research capacity is a critical component of pandemic preparedness, as highlighted by the challenges faced during the Ebola outbreak in West Africa. Recent global initiatives, such as the Research & Development Task Force of the Global Health Security Agenda and the World Health Assembly's resolution on strengthening clinical trials, emphasize the need for robust research capabilities. This Perspective discusses the experiences of leaders in infectious disease research and capacity building in low- and middle-income countries, focusing on Colombia, Jamaica, and Pakistan. These case studies underscore the importance of collaborative efforts, interdisciplinary training, and global partnerships in pandemic response. The experiences …

Plasma Cell Free Dna (Cfdna) Test For Diagnosis Of Infectious Diseases In Children: A Tertiary Care Children's Hospital Experience, Guyu Li, Pamela Campos, Utpal Bhalala, Jaime Fergie

Research Symposium

Introduction: Plasma cell free DNA (cfDNA) test (Karius Test®, KT) has emerged as an attractive diagnostic modality allowing noninvasive broad-range pathogen detection, and fast diagnosis. There are however few studies examining the impact of the KT in the diagnosis and management of infections in children. Our study aimed at evaluating the clinical impact of plasma cfDNA test since it was used at our institution.

Methods: Our retrospective study included children between 0 to 21 years of age who were admitted to Driscoll Children’s Hospital, Corpus Christi, Texas between January 2019 and January 2022. Demographic and clinical course data were collected. …

Interplay Between Acetylation And Ubiquitination Of Imitation Switch Chromatin Remodeler Isw1 Confers Multidrug Resistance In Cryptococcus Neoformans, Yang Meng, Yue Ni, Zhuoran Li, Tianhang Jiang, Tianshu Sun, Yanjian Li, Xindi Gao, Hailong Li, Chenhao Suo, Chao Li, Sheng Yang, Tian Lan, Guojian Liao, Tongbao Liu, Ping Wang, Chen Ding

School of Medicine Faculty Publications

Cryptococcus neoformans poses a threat to human health, but anticryptococcal therapy is hampered by the emergence of drug resistance, whose underlying mechanisms remain poorly understood. Herein, we discovered that Isw1, an imitation switch chromatin remodeling ATPase, functions as a master modulator of genes responsible for in vivo and in vitro multidrug resistance in C. neoformans. Cells with the disrupted ISW1 gene exhibited profound resistance to multiple antifungal drugs. Mass spectrometry analysis revealed that Isw1 is both acetylated and ubiquitinated, suggesting that an interplay between these two modification events exists to govern Isw1 function. Mutagenesis studies of acetylation and ubiquitination sites …

Solitary Confinement In Sheep’S Clothing: The Unlawfulness Of Medical Isolation Protocols During The Covid-19 Pandemic In American Prisons, Alexandra Franchino

Seton Hall Law Review

No abstract provided.

Research On Campus Epidemic Evolution Based On Multi-Scale Modeling And Simulation In Microscopic & Microscopic View, Mingwei Hu, Wenjie Yang

Journal of System Simulation

Abstract: High density of population leads to high possibility of cross-infection. It is necessary to focus on campus epidemic prevention and control. Basing on existing studies in macroscopic or microscopic view, this paper proposed a multi-scale means to analyze a short-term evolution of Corona virus disease 2019 (COVID-19) on campus and estimated the efficiency of prevention strategies. Macroscopic model was based on the susceptible-exposed-infections-recovered(SEIR) model, which exported the time curve of the number of asymptomatic patients and symptomatic patients. Microscopic model combined discrete event simulation modeling and agent-based modeling to simulate the behavior of campus students and the state evolution …

Research Progress In High-Throughput Phenotype Testing Technology And Equipment For Engineering Cells Based On Microfluidics, Shuang Li, Xiaojie Guo, Haibo Chen, Sisi Chen, Xin Da, Zhenghui Li, Qinxiu Liu, Yi Wang, Xinhui Xing, Chong Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Engineering cells are a core component of green bio-manufacturing. The efficient testing and acquisition of engineering cells with the desired phenotype is a critical factor in the successful implementation of bio-manufacturing. In recent years, based on microfluidics technologies, non-culture type single-cell phenotype high-throughput test equipment and culture type phenotype high-throughput test equipment for the growth and metabolism of single cell in a bioreactor have been developed such as microdroplet and microchamber, realizing high-throughput, automated, miniaturized, and integrated testing of the phenotypes of engineering cells and providing a powerful tool for the breeding of engineering cells. This review systematically compiles the …

Analysis On Development Status And Characteristics Of Non-Governmental Bio-Safety And Bio-Security Think Tanks In The United States, Wenbing Ma, Qiang Song, Lei Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

At present, the complexity of bio-safety governance is becoming increasingly prominent, and complex issues such as security and development in the bio-economy, preparedness and response to infectious disease pandemics, the interweaving and integration of bio-security and other security factors, and the integration of scientific and technological factors and security factors urgently require think tanks to conduct systematic, comprehensive and forward-looking assessments and provide professional solutions. Rooted in the relatively mature experience in the construction of think tanks in the United States, a number of bio-safety and bio-security think tanks with greater influence have been developed, which have acted as an …

Integrating Health Equity Into Implementation Science To Advance Chronic Disease Prevention And Control, Callie Walsh-Bailey

Brown School Graduate Student Theses and Dissertations

Marginalized populations are inequitably burdened by chronic diseases such as diabetes, heart disease, obesity, and cancer. The goal of health equity work is to ensure all people have a fair and just opportunity to achieve optimal health. Implementation science has made health equity a greater focus and priority in recent years. There has been a proliferation of guidance on what implementation science needs to do to advance equity. However, the field currently lacks specific, actionable guidance on how to integrate equity. The overarching goal of this dissertation is to synthesize conceptual and theoretical underpinnings regarding health equity and bring them …

The Effects Of The Coronavirus Pandemic On Women Working In The Private Sector: A Study Applied To A Sample Of Saudi Women Working In The Private Sector, Norah Basheer Alotaibi

Information Sciences Letters

This research paper aims to identify the psychological, social, and economic effects of the Coronavirus pandemic on Saudi women working in the private sector and present many recommendations that contribute to limit these effects. To achieve the objectives of this research, the social survey approach was adopted by using the random sample method. The study was applied to a sample consisting of (395) Saudi women working in the private sector in different small and medium enterprises affiliated with the Ministry of Human Resources and Social Development. A questionnaire was used to collect the necessary information and data. The results revealed …

Endurance Track: A Comprehensive Embedded System For Equestrian Endurance Race Management, Alaaeddine Ramadan, Mahmoud Mohamad, Ebrahim Alamari, Chamseddine Zaki

Information Sciences Letters

Digital transformation in horse businesses occurs by providing software and hardware solutions to virtually assist the stables’ everyday operations. In this paper, we propose a system that aims to help the Equestrian Federation in Bahrain hold all the things related to endurance races in Bahrain and during international competitions. It consolidates all of the information about the horses, stables, and stakeholders into one system. It centralizes horse, stable, and stakeholder data. A smart wearable horse health monitoring device uses Internet of Things sensors like a heart rate (HR) sensor to assess the horse’s HR throughout the race and inform the …

Degree Of Employing Blended Learning, Difficulties, And Needs At The Jordanian Universities: Faculty Members Perspective, Tahani F. Abu Jreiban

Information Sciences Letters

The aim of this study is to recognize the degree of employing blended learning, difficulties, and needs at Jordanian universities from the faculty member’s perspective. To achieve the objective’s study the descriptive survey method was used, and the sample of this study consisted of (300) faculty members who were randomly selected from the University of Jordan and Al-Zaytoonah University of Jordan. The researchers used three types of questionnaires as a tool in this work. The first one was used to measure the extent of use of blended learning by the faculty members which contained 20 paragraphs, while the second questionnaire …

3d Modeling Reveals Functionality Of A Healed But Malaligned Leg Fracture In A White-Faced Storm Petrel Pelagodroma Marina, J. Reichert, G. Mayr, T. Wilke, W. S. Peters

Marine Ornithology

No abstract provided.

Physiological Toolkit To Assess The Health Impacts On A Magellanic Penguin Spheniscus Magellanicus Colony Located In A High-Use Touristic Region Of Patagonia, Argentina, V. L. D'Amico, M. Bertellotti

Marine Ornithology

No abstract provided.

Interseasonal Movements And Non-Breeding Locations Of Aleutian Terns Onychoprion Aleuticus, M. I. Goldstein, D. C. Duffy, S. Oehlers, N. Catterson, J. Frederick, S. Pyare

Marine Ornithology

No abstract provided.

Bill Deformities In Penguins (Spheniscidae): A Global Review, Christopher W. Jones, Michelle M. Risi, Werner Kuntz, Peter G. Ryan, Antje Steinfurth, Alexander L. Bond

Marine Ornithology

No abstract provided.

Band Recoveries And Juvenile Dispersal Of Southern Giant-Petrels Macronectes Giganteus Marked As Chicks In Antarctica By The Brazilian Antarctic Program (1984-1993), M. Sander, S. A. Garcia, A. P.B. Carneiro, S. I. Cristofoli, M. J. Polito

Marine Ornithology

No abstract provided.

Beach Surveys Past, Present And Future: Toward A Global Surveillance Network For Stranded Seabirds, S. H. Newman, R. J. Harris, F. S. Tseng

Marine Ornithology

No abstract provided.

A Historical Account Of Oiled Wildlife Care In California, S. H. Newman, M. H. Ziccardi, A. B. Berkner, J. Holcomb, C. Clumpner, J. A. K. Mazet

Marine Ornithology

No abstract provided.

Possible Risk Of Lyme Disease From Bites By Ticks At Seabird Colonies, Marine Ornithology

Marine Ornithology

No abstract provided.

Factors Associated With Hiv Testing Among Pregnant Women In Rwanda: A Nationwide Cross-Sectional Survey, Lilian Nuwabaine, Joseph Kawuki, Angella Namulema, John Baptist Asiimwe, Quraish Sserwanja, Ghislaine Gatasi, Elorm Donkor

School of Nursing & Midwifery, East Africa

Human immunodeficiency virus (HIV) testing during pregnancy is crucial for the prevention of mother-to-child transmission of HIV, through aiding prompt treatment, care, and support. However, few studies have explored HIV testing among pregnant women in Rwanda. This study, therefore, aimed to determine the prevalence and associated factors of HIV testing among pregnant women in Rwanda. We used secondary data from the 2020 Rwanda Demographic and Health Survey (RDHS), comprising 870 pregnant women. Multistage stratified sampling was used by the RDHS team to select participants. We conducted bivariable and multivariable logistic regression to explore factors associated with HIV testing using SPSS …

Exploring The Role Of Information And Communication Technologies In Allergic Rhinitis In Specialist Centers: Patient Perspectives On Usefulness, Value, And Impact On Healthcare, Ivan Cherrez-Ojeda, Jean Bousquet, Zouina Sarfraz, Azza Sarfraz, Monica Rodriguez Gonzales, Anna Bedbrook, Nelson Rosario, Benjamin Zepeda-Ortega, Guillermo Guidos, Ulbio Alcivar Molina

Department of Paediatrics and Child Health

Introduction: Information and communication technologies (ICTs) improve patient-centered care and are routinely used in Allergic Rhinitis (AR), but patients' preferences and attitudes are unexplored. This study examines AR-related information preferences and ICT use by AR patients.
Methods: A survey-based cross-sectional study was carried out in Ecuador from July to September 2019 in seven centers of reference for allergic disease. Participants were 18 years or older, diagnosed with AR and had access to ICT and the Internet. Descriptive and binomial logistic regressions were performed. A value of less than 0.05 was considered statistically significant.
Results: 217 patients were included. 47% (n …