Digital Commons Network^™

Improving Cardiopulmonary Resuscitation Education In Undergraduate Nursing Programs, Robin E. Roberts

Electronic Theses and Dissertations

Ongoing competency validation of cardiopulmonary resuscitation (CPR) skills is not a routine practice in nursing school. Basic Life Support training and certification is obtained before or during nursing school with little opportunity for practice. Poor quality cardiopulmonary resuscitation skills can affect the confidence level of the performer and the patient outcome. The aim of this study was to explore the effect of training nursing faculty on the adoption of cardiopulmonary resuscitation technology into nursing school curriculum to provide improved cardiopulmonary resuscitation skills to nursing students. Using a pretest-posttest, this study followed the Kirkpatrick model of evaluation of continuing education, which …

What Fine Arts Teachers In Public High Schools Report The Quality Of Their Programs: A Narrative Analysis, Zachary Perry

Student Theses and Dissertations

The purpose of this study was to understand how fine art teachers viewed the quality of their programs within public school settings. The purpose was to also learn how funding can potentially affect the quality of a fine arts program from the stories of public high school fine arts educators. Goodson’s theory of educational change was used to explain teachers’ happiness and job satisfaction with their programs, thanks to the levels of support and funding, and how that can affect the quality of their fine arts programs. Moreover, the themes drawn from this study included: (a) administrative support, (b) proper …

Safety, Immunogenicity, And Mechanism Of A Rotavirus Mrna-Lnp Vaccine In Mice, Chenxing Lu, Yan Li, Rong Chen, Xiaoqing Hu, Qingmei Leng, Xiaopeng Song, Xiaochen Lin, Jun Ye, Jinlan Wang, Jinmei Li, Lida Yao, Xianqiong Tang, Xiangjun Kuang, Guangming Zhang, Maosheng Sun, Yan Zhou, Hongjun Li

Faculty, Staff and Student Publications

Rotaviruses (RVs) are a major cause of diarrhea in young children worldwide. The currently available and licensed vaccines contain live attenuated RVs. Optimization of live attenuated RV vaccines or developing non-replicating RV (e.g., mRNA) vaccines is crucial for reducing the morbidity and mortality from RV infections. Herein, a nucleoside-modified mRNA vaccine encapsulated in lipid nanoparticles (LNP) and encoding the VP7 protein from the G1 type of RV was developed. The 5' untranslated region of an isolated human RV was utilized for the mRNA vaccine. After undergoing quality inspection, the VP7-mRNA vaccine was injected by subcutaneous or intramuscular routes into mice. …

Ideology Of Disaster Education Trauma Handling Post-Earthquake In Picture Stories Book: Critical Discourse Analysis, Silvia Damayanti, I Nyoman Suarka, Maria Matildis Banda, Ketut Widya Purnawati

International Review of Humanities Studies

This research analyzes the ideology that the author intends to instill in picture storybooks for children in Japan. The study aims to explore how the author conveys the ideology of handling trauma in children after earthquake disasters. The objects of the study are two picture storybooks titled "Yuzuchan" and "Yappari Ouchi Ga Ii Na." The research was conducted qualitatively using the documentary data search method. The analysis was carried out with van Dijk's CDA theory and Peirce's Semiotics Theory. The results of the analysis reveal that "Yuzuchan" and "Yappari Ouchi Ga Ii Na" are picture storybooks produced to help children …

Nigerian Politicians And Language Use During Political Compaigns: A Studi Of Select Speeches, Miriam Stephen Inegbe

International Review of Humanities Studies

This essay appraised linguistic features in selected utterances of some prominent and leading Nigerian politicians during political rallies held between October and December, 2022. These utterances, which serve as data for this paper were extracted from some Nigerian tabloids like NaijaNews.com, Opera News, Politic.nigeria.com, RealMedia, Vanguard News, Voice of the People (VoP) and www.thisdaylive.com. In linguistics, utterances are viewed as unit of speech. The significant meaning of speech, therefore, embeds in the utterance which may provide a basis for social positions and further interpretative actions or decisions by the listener. The data for this study were eleven (11) purposively selected …

Fabp4 And Metabolite Profile In Lipopolysaccharide-Induced Mice Model Treated With Moringa Oleifera Ethanol Leaf Extract, Cenia P. Hanifah, Ifa Sulistiyorini, Vanessa A. Sumirat, Neni Anggraeni, Mirasari Putri, Mohammad Ghozali, Mas Rizky A.A Syamsunarno

Pharmacology and Clinical Pharmacy Research

Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infection, induces changes in blood cells and metabolic alterations. Fatty acid binding protein 4 (FABP4), a lipid chaperone predominantly expressed in adipose tissue, is modulated in sepsis and may contribute to metabolic and immunologic changes. Moringa oleifera (M. oleifera) leaf extract (MOLE) is known to modulate immune system activity, but its potential for treating acute inflammatory conditions like sepsis remains unclear. This study investigates the ability of MOLE to modulate metabolite and hematological profiles in lipopolysaccharide (LPS)-induced sepsis in mice. Thirty-five male Swiss Webster mice (Mus musculus) were …

Caring, 1978, V2 N4, Fall, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article on the oncology unit as well as news about staffing, publications, events, and other updates.

Caring, 1979, V3 N1, Spring, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article on the rise and prominence of ambulatory care as well as news about staffing, publications, events, and other updates.

Caring, 1979, V3 N2, Summer, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article with advice on how to navigate medical care as well as news about staffing, publications, events, and other updates.

There is a 10-year follow up to the "Tranquility Ball" and fundraising event with Buzz Aldrin in 1969. For more information on this event, see this issue of Around & About Illinois Masonic Medical Center.

A Study To Assess The Effect Of Back Massage On Amount Of Breast Milk Among Mothers Of Neonates Admitted In Nicu At A Selected Hospital, Calicut., Aswathi A, Soya K

Manipal Journal of Nursing and Health Sciences

Abstract

Breastfeeding is one of the most natural act and intimate human interaction. Separation of mother and baby after birth creates an interruption in maintaining lactation. The main objective of this study was to identify the effect of back massage on amount of breast milk among mothers of neonates admitted in NICU. An experimental pretest-posttest control group design was adopted. The tools used were baseline proforma, calibrated breastmilk measuring cup and breast milk volume diary. Subjects were selected using consecutive sampling and allocated as 30 in each group. As first step baseline data were collected. Then the amount of expressed …

Autophagy And Cell Wall Integrity Pathways Coordinately Regulate The Development And Pathogenicity Through Moatg4 Phosphorylation In Magnaporthe Oryzae, Pusheng Guo, Yurong Wang, Jiayun Xu, Zhixiang Yang, Ziqi Zhang, Jinyi Qian, Jiexiong Hu, Ziyi Yin, Leiyun Yang, Muxing Liu, Xinyu Liu, Gang Li, Haifeng Zhang, Ryan Rumsey, Ping Wang, Zhengguang Zhang

School of Medicine Faculty Publications

Autophagy and Cell wall integrity (CWI) signaling are critical stress-responsive processes during fungal infection of host plants. In the rice blast fungus Magnaporthe oryzae, autophagy-related (ATG) proteins phosphorylate CWI kinases to regulate virulence; however, how autophagy interplays with CWI signaling to coordinate such regulation remains unknown. Here, we have identified the phosphorylation of ATG protein MoAtg4 as an important process in the coordination between autophagy and CWI in M. oryzae. The ATG kinase MoAtg1 phosphorylates MoAtg4 to inhibit the deconjugation and recycling of the key ATG protein MoAtg8. At the same time, MoMkk1, a core kinase of CWI, also phosphorylates …

Complement Receptor 1 Is The Human Erythrocyte Receptor For Plasmodium Vivax Erythrocyte Binding Protein, Seong-Kyun Lee, Cécile Crosnier, Paola Carolina Valenzuela-Leon, Brian L P Dizon, John P Atkinson, Jianbing Mu, Gavin J Wright, Eric Calvo, Karthigayan Gunalan, Louis H Miller

2020-Current year OA Pubs

The discovery that Africans were resistant to infection by

Enhancing Antibody Responses By Multivalent Antigen Display On Thymus-Independent Dna Origami Scaffolds, Eike-Christian Wamhoff, James Brett Case, Shilpa Sanapala, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and can induce B cell responses that may neutralize the platform. Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. Sequential immunization of mice with DNA-based VLPs (DNA-VLPs) elicits protective neutralizing antibodies to SARS-CoV-2 in a manner that depends on the valency of the antigen displayed and on T …

Invasive Group A Streptococcus In Infants Less Than 1-Year Of Age From 2012 To 2022: A Single-Center Experience, Taylor Nack, Jesus G Vallejo, James Dunn, Anthony R Flores, J Chase Mcneil

Faculty, Staff and Students Publications

The incidence of invasive Group A Streptococcus (iGAS) has varied throughout the COVID-19 pandemic. We reviewed iGAS infections in infants ≤1 year from 2012 to 2022. Twenty-five percent of cases occurred in the last quarter of 2022. Pneumonia (21.8%) was the most common presentation. Twenty-one patients (65.6%) were successfully transitioned to oral antibiotics.

Novel Advancements In Covid-19 And Neuroscience, Alessio Simonetti, Evelina Bernardi, Gabriele Sani

Faculty, Staff and Students Publications

From an initial cluster of cases reported in Wuhan, the SARS-Cov-2 infection has since spread globally, causing a pandemic that began on 11 March 2020 [...].

Reviewing The Clostridioides Difficile Mouse Model: Insights Into Infection Mechanisms, José L Fachi, Marco A R Vinolo, Marco Colonna

2020-Current year OA Pubs

No abstract provided.

A Tale Of Two Viruses: Why Smallpox Was Eradicated And Polio Persists, Katherine G. Mcgough, Erin N. Bodine

Spora: A Journal of Biomathematics

The smallpox and poliomyelitis (polio) viruses were, at a time, one of the largest threats to global public health killing millions until global eradication campaigns were put into effect. Vaccination led to the eradication of smallpox and the elimination of polio for most of the world. However, polio continues to persist at endemic levels in Pakistan and Afghanistan. We developed ODE models of smallpox and polio to explore differences in transmission dynamics and determine if the underlying biology has made poliomyelitis more difficult to eradicate. Our model analysis shows there are multiple factors which should allow polio to have a …

Investigation Into Cardiacmyhc-Α 334–352-Specific Tcr Transgenic Mice Reveals A Role For Cytotoxic Cd4 T Cells In The Development Of Cardiac Autoimmunity, Meghna Sur, Mahima T. Rasquinha, Kiruthiga Mone, Chandirasegaran Massilamany, Ninaad Lasrado, Channabasavaiah B. Gurumurthy, Raymond A. Sobel, Jay Reddy

Jay Reddy Publications

Myocarditis is one of the major causes of heart failure in children and young adults and can lead to dilated cardiomyopathy. Lymphocytic myocarditis could result from autoreactive CD4+ and CD8+ T cells, but defining antigen specificity in disease pathogenesis is challenging. To address this issue, we generated T cell receptor (TCR) transgenic (Tg) C57BL/6J mice specific to cardiac myosin heavy chain (Myhc)-α 334–352 and found that Myhc-α-specific TCRs were expressed in both CD4⁺ and CD8⁺ T cells. To investigate if the phenotype is more pronounced in a myocarditis-susceptible genetic background, we backcrossed with A/J mice. At the fourth …

Usa V. Michael Kramer

2024 Decisions

USDC for the Western District of Pennsylvania

Bacterial Contamination Of Platelet Products, Michael R Jacobs, Bowen Zhou, Aditi Tayal, Robert W Maitta

Faculty, Staff and Student Publications

Transfusion of bacterially contaminated platelets, although rare, is still a major cause of mortality and morbidity despite the introduction of many methods to limit this over the past 20 years. The methods used include improved donor skin disinfection, diversion of the first part of donations, use of apheresis platelet units rather than whole-blood derived pools, primary and secondary testing by culture or rapid test, and use of pathogen reduction. Primary culture has been in use the US since 2004, using culture 24 h after collection of volumes of 4-8 mL from apheresis collections and whole-blood derived pools inoculated into aerobic …

Medical School Watercooler Newsletter - January 25, 2024, Lindsey Lyle

Watercooler Newsletter

This is the January 25, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Whiddon COM alumna returns to USA Health as hospitalist
• Meet a Med Student: Ryan McIlwain
• OB/GYN Student Interest Group hosts period product drive through Feb. 9
• Grelet presents research at mitochondria conference in Berlin

A Five-Year Quasi-Experimental Study To Evaluate The Impact Of Empiric Antibiotic Order Sets On Antibiotic Use Metrics Among Hospitalized Adult Patients, Wesley D. Kufel, Jeffrey M. Steele, Rahul Mahapatra, Mitchell V. Brodey, Dongliang Wang, Kristopher M. Paolino, Paul Suits, Derek W. Empey, Stephen J. Thomas

Pharmacy Faculty Scholarship

Objective: Evaluation of adult antibiotic order sets (AOSs) on antibiotic stewardship metrics has been limited. The primary outcome was to evaluate the standardized antimicrobial administration ratio (SAAR). Secondary outcomes included antibiotic days of therapy (DOT) per 1,000 patient days (PD); selected antibiotic use; AOS utilization; Clostridioides difficile infection (CDI) cases; and clinicians’ perceptions of the AOS via a survey following the final study phase.

Design: This 5-year, single-center, quasi-experimental study comprised 5 phases from 2017 to 2022 over 10-month periods between August 1 and May 31.

Setting: The study was conducted in a 752-bed tertiary care, academic medical center.

Intervention: …

Prevention And Potential Treatment Strategies For Respiratory Syncytial Virus, Bo-Wen Sun, Peng-Peng Zhang, Zong-Hao Wang, Xia Yao, Meng-Lan He, Rui-Ting Bai, Hao Che, Jing Lin, Tian Xie, Zi Hui, Xiang-Yang Ye, Li-Wei Wang

Faculty, Staff and Student Publications

Respiratory syncytial virus (RSV) is a significant viral pathogen that causes respiratory infections in infants, the elderly, and immunocompromised individuals. RSV-related illnesses impose a substantial economic burden worldwide annually. The molecular structure, function, and in vivo interaction mechanisms of RSV have received more comprehensive attention in recent times, and significant progress has been made in developing inhibitors targeting various stages of the RSV replication cycle. These include fusion inhibitors, RSV polymerase inhibitors, and nucleoprotein inhibitors, as well as FDA-approved RSV prophylactic drugs palivizumab and nirsevimab. The research community is hopeful that these developments might provide easier access to knowledge and …

The Durability Of Antibody Responses Of Two Doses Of High-Dose Relative To Two Doses Of Standard-Dose Inactivated Influenza Vaccine In Pediatric Hematopoietic Cell Transplant Recipients: A Multi-Center Randomized Controlled Trial., Jennifer E. Schuster, Lubna Hamdan, Daniel E. Dulek, Carrie L. Kitko, Einas Batarseh, Zaid Haddadin, Laura S. Stewart, Anna Stahl, Molly Potter, Herdi Rahman, Spyros A. Kalams, Claire E. Bocchini, Elizabeth A. Moulton, Susan E. Coffin, Monica I. Ardura, Rachel L. Wattier, Gabriela Maron, Michael Grimley, Grant Paulsen, Christopher J. Harrison, Jason L. Freedman, Paul A. Carpenter, Janet A. Englund, Flor M. Munoz, Lara Danziger-Isakov, Andrew J. Spieker, Natasha B. Halasa, Pediatric Hct Flu Study

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Our previous study established a 2-dose regimen of high-dose trivalent influenza vaccine (HD-TIV) to be immunogenically superior compared to a 2-dose regimen of standard-dose quadrivalent influenza vaccine (SD-QIV) in pediatric allogeneic hematopoietic cell transplant (HCT) recipients. However, the durability of immunogenicity and the role of time post-HCT at immunization as an effect modifier are unknown.

METHODS: This phase II, multi-center, double-blinded, randomized controlled trial compared HD-TIV to SD-QIV in children 3-17 years old who were 3-35 months post-allogeneic HCT, with each formulation administered twice, 28-42 days apart. Hemagglutination inhibition (HAI) titers were measured at baseline, 28-42 days following each …

Effect Of External Application Of Traditional Herbal Medicine On Burn Wound Ulcers: A Meta-Analysis, Ahmed Khalid Aldhalmi, Mohamed Abdelrahman, Mohamed E.A. Abdelrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The aim of the meta-analysis was to assess and contrast the effects of externally administered traditional herbal medicine on burn wound ulcers. This meta-analysis utilized dichotomous or contentious random or fixed-effect models to examine the outcomes. The odds ratio (OR) and mean difference (MD) were calculated, along with 95% confidence intervals (CIs). The present meta-analysis incorporated a total of 13 studies conducted between 1999 and 2020, which collectively had a sample size of 1282 individuals diagnosed with burn wound ulcers. Overall evaluation of traditional herbal medicine showed significantly shorter wound healing times (MD, -6.81; 95% CI, -8.81,-4.81, p<0.001) compared to standard treatment in personnel with burn wound ulcers. Traditional herbal medicine alone had a significantly shorter wound healing time (MD, -5.74; 95% CI, -8.00- -3.49, p<0.001) compared to standard treatment in personnel with burn wound ulcers. Traditional herbal medicine and Basic Fibroblast Growth Factor had significantly shorter wound healing times (MD, -9.93; 95% CI, -11.18- -8.68, p<0.001) compared to standard treatment in patients with burn wound ulcers. The examined data revealed that traditional herbal medicine with or without Basic Fibroblast Growth Factor had a significantly shorter wound healing time compared to standard treatment for burn wound ulcers. However, it is important to be mindful of its values, as a considerable portion of the chosen studies featured a small sample size.

Effect Of Chinese Herbal Medicine As An Adjunctive Technique To Standard Treatment For People With Diabetic Foot Ulcers: A Meta-Analysis, Haitham Saeed, Ali Jihad Hemid Al-Athari, Marwa O. Elgendy

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The meta-analysis aimed to assess and compare the effect of Chinese herbal medicine as an adjunctive technique to standard treatment for people with diabetic foot ulcers. This meta-analysis investigated the results through either dichotomous or contentious random or fixed effect models, calculating the odds ratio (OR) and mean difference (MD) along with 95% confidence intervals (CIs). The analysis included 17 studies conducted between 2006 and 2021, comprising a total of 1140 individuals with diabetic foot ulcers. Chinese herbal medicine had a significantly higher total effective rate (OR, 2.77; 95% CI, 1.89-4.07, p<0.001), lower wound size after treatment (MD, -2.44; 95% CI, -3.46- -1.43, p<0.001), lower number of patients without any improvement (OR, 0.26; 95% CI, 0.15-0.45, p<0.001), and lower time of diabetic wound ulcer healing (MD, -10.46; 95% CI, -14.91- -6.37, p<0.001) compared to standard treatment in personal with diabetic foot ulcers. However, no significant differences were found between Chinese herbal medicine and standard treatment in the number of patients with 30% or more reductions in the ulcer area of the diabetic foot ulcer (OR, 2.69; 95% CI, 0.70-10.30, p=0.15). The examined data revealed that Chinese herbal medicine had a significantly higher total effective rate, lower wound size after treatment, lower number of patients without any improvement, and lower time of diabetic wound ulcer healing, however, no significant differences were found in the number of patients with 30% or more reductions in the ulcer area compared to standard treatment in personal with diabetic foot ulcers. However, caution should be exercised when interpreting its findings, as many of the chosen studies had a small sample size, and certain comparisons were based on a limited number of selected studies.

Social Determinants Of Health, Comorbidities, And Covid-19 Among Adults Aged 18 And Older In Indiana, Kandeh Kamara

Walden Dissertations and Doctoral Studies

No abstract provided.

A Research Center At The End Of The World A Study Of Local Writing Practices In A Global Context, Ana María Cortés Lagos

Dissertations - ALL

How do transnational flows and collaborations shape scientific research writing? What role do local language practices play in a global science context? Or how do phenomena of globalization and internationalization impact the work of scientists writing for local audiences and “with a local eye”? Through a case study drawing on memory, archival material, and interviews, this dissertation explores the language practices of a team of vaccine researchers working from a country in the global semi-periphery (Chile). Drawing on elements of mobility, activity and genre theories, this study traces the work of these scientists across space and time and shows how …

Targeted Repression Of Topa By Crispri Reveals A Critical Function For Balanced Dna Topoisomerase I Activity In The Chlamydia Trachomatis Developmental Cycle, Li Shen, Leiqiong Gao, Abigail R. Swoboda, Scot P. Ouellette

School of Medicine Faculty Publications

Chlamydia trachomatis is an obligate intracellular bacterium that is responsible for the most prevalent bacterial sexually transmitted infection. Changes in DNA topology in this pathogen have been linked to its pathogenicity-associated developmental cycle. Here, evidence is provided that the balanced activity of DNA topoisomerases contributes to controlling Chlamydia developmental processes. Utilizing catalytically inactivated Cas12 (dCas12)-based clustered regularly interspaced short palindromic repeats interference (CRISPRi) technology, we demonstrate targeted knockdown of chromosomal topA transcription in C. trachomatis without detected toxicity of dCas12. Repression of topA impaired the developmental cycle of C. trachomatis mostly through disruption of its differentiation from a replicative form …

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge As Inhibitors Of Plasmodium Falciparum, Sandra Johannsen, Robin M. Gierse, Arne KrüGer, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha De Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie University Of Nebraska-Lincoln,, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa De Souza, Melloney Dröge, Bernard Van Vliet, Jack Den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K.H. Hirsch

Department of Agronomy and Horticulture: Faculty Publications

In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing, and compounds with different modes of action are urgently needed. One promising drug target is the enzyme 1-deoxy-D-xylulose-5- phosphate synthase (DXPS) of the methylerythritol 4-phosphate (MEP) pathway for which we have previously identified three active compound classes against Mycobacterium tuberculosis. The close structural similarities of the active sites of the DXPS enzymes of P. falciparum and M. tuberculosis prompted investigation of their antiparasitic action, all classes …