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Macrophage-Driven Car T Cell Resistance In B Cell Lymphoma, Sae Bom Lee

USF Tampa Graduate Theses and Dissertations

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of patients with relapsed/ refractory large B cell lymphoma (LBCL). Despite its promising efficacy, a subset of patients experiences primary resistance or relapse. In Chapter 2, we explore the tumor microenvironment (TME)-induced resistance mechanisms in patients with LBCL. Analysis of the intratumoral immune infiltrates in pre-infusion tumor biopsies revealed that the levels of immunoregulatory macrophages were elevated in patients who responded poorly to axicabtagene ciloleucel (axi-cel). Using preclinical mouse B cell tumor models, we found that the CAR T-cell-produced interferon-gamma (IFN-γ) enhanced the expression of inducible nitric oxide synthase (iNOS, …

Self-Swabbing Versus Assisted Swabbing For Viral Detection By Qrt-Pcr: The Experience From Sars-Cov-2 Based On A Meta-Analysis Of Six Prospectively Designed Evaluations Conducted In A Uk Setting, Tom Fowler, David Chapman, Matthias E Futschik, Sarah A Tunkel, Edward Blandford, Elena Turek, Olumide Kolade, Sergio Souza Da Cunha, Andrew Dodgson, Paul Klapper, Malur Sudhanva, Lindsey Davies, Sue Hill, Susan Hopkins, Tim Peto

School of Biomedical Sciences

PURPOSE: In April 2020, the UK Government implemented NHS Test and Trace to provide SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (qRT-PCR) testing for the public, with nose-and-throat swabbing for samples performed by trained staff. Self-swabbing (SS) would allow rapid scale-up of testing capacity and access. Six studies were undertaken to determine whether SS was as effective for detecting SARS-CoV-2 as swabbing performed by trained staff.

METHODS: Six prospective studies were conducted between April-October 2020, using six swab/media combinations. Differences between assisted swabbing (AS) and SS were evaluated for concordance, positivity, sensitivity, cycle threshold (Ct) values and void rates. Statistical …

Rapid, Direct Screening Of Priority Metal Contaminants In Environmental Systems With Reactive 3 D-Printed Cone Spray Ionization-Mass Spectrometry ( 3 D- Pcsi-Ms ), Jonathan Nzubechi Chilaka

Theses and Dissertations

Trace metal species are relatively common in our environment, and although some are essential to sustain life, exposure to elevated levels of toxic metals can detrimentally affect both human and animal health. Correspondingly, monitoring of such contaminants in environmental systems is critical to public safety. While various methods exist for sensitive and selective metal analysis for such applications, there remains a need for a rapid, cost-effective, and, ideally, portable solution for expedited results and more impactful remediation and sustainability initiatives. Here, we investigate the use of 3D-printed cone spray ionization-mass spectrometry (3D-PCSI-MS), a newer, spray-based ambient ionization method, with specialty …

Protein Nanoparticles As Vaccine Platforms For Human And Zoonotic Viruses, Kush Kumar Pandey, Bikash R. Sahoo, Asit K. Pattnaik

Nebraska Center for Virology: Faculty Publications

Vaccines are one of the most effective medical interventions, playing a pivotal role in treating infectious diseases. Although traditional vaccines comprise killed, inactivated, or liveattenuated pathogens that have resulted in protective immune responses, the negative consequences of their administration have been well appreciated. Modern vaccines have evolved to contain purified antigenic subunits, epitopes, or antigen-encoding mRNAs, rendering them relatively safe. However, reduced humoral and cellular responses pose major challenges to these subunit vaccines. Protein nanoparticle (PNP)-based vaccines have garnered substantial interest in recent years for their ability to present a repetitive array of antigens for improving immunogenicity and enhancing protective …

The Emerging Biomarkers In Chronic Obstructive Pulmonary Disease: A Narrative Review, Kaitlin M Phillips, Philip F Lavere, Nicola A Hanania, Muhammad Adrish

Faculty, Staff and Students Publications

The burden of chronic obstructive pulmonary disease (COPD) is increasing, especially for women in low-to-middle income countries. Biomarkers provide ever-increasing diagnostic precision for COPD and show promise for primary, secondary, and tertiary disease prevention. This review describes emerging applications for biomarkers in COPD, especially as they align with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) emphasis on prevention, early diagnosis, and response to therapy. These biomarkers include blood eosinophils; IgE; C-reactive protein; fibrinogen; procalcitonin; interleukins 6, 8, and 33; tumor necrosis factor alpha; and soluble receptor for advanced glycated products (sRAGE). They have been used in various ways …

Community-Acquired Pneumonia: The Importance Of The Early Detection Of Drug-Resistant Organisms, Sai Doppalapudi, Muhammad Adrish

Faculty, Staff and Students Publications

Pneumonia is a disease associated with significant healthcare burden with over 1.5 million hospitalizations annually and is the eighth leading cause of death in the United States. While community-acquired pneumonia (CAP) is generally considered an acute time-limited illness, it is associated with high long-term mortality, with nearly one-third of patients requiring hospitalization dying within one year. An increasing trend of detecting multidrug-resistant (MDR) organisms causing CAP has been observed, especially in the Western world. In this editorial, we discuss about a publication by Jatteppanavar

Establishment Of Bacteroides In The Gut And Its Role In The Cystic Fibrosis Gut-Lung Axis, Rebecca A. Valls

Dartmouth College Ph.D Dissertations

In the quest to understand the complex interplay between the gut microbiota and cystic fibrosis (CF), a disease characterized by chronic upper respiratory complications and an exacerbated proinflammatory response, our lab engaged in a collaborative study with Dartmouth-Hitchcock Medical Center (DHMC) to characterize the gut microbiota of pediatric CF patients. Initial analyses established a connection between gut microbial composition and respiratory health, particularly highlighting a scarcity of Bacteroides species compared to healthy controls. In following investigations, we utilized random forest models to understand how stool microbiota may influence clinical outcomes of these pediatric CF patients, including: age, upper respiratory infections, …

Noda News December 2013

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News Summer 2014

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News October 2022

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Inspire : Vol 7 Issue 6, Department Of Medicine

INSPIRE – Department of Medicine Archives

• Message from the Chair
• Medicine at National and International Forums Digestive disease week (DDW) 2024
• ACGME-I Self-Empowerment Workshop for Program Coordinators
• The 2nd International Collaborative Mycology Conference
• World hypertension day
• Research Module
• SIMPACT 2024
• Combatting Corticosteroid Misuse: Safeguarding Skin Health in Pakistan
• 2024 Inter Departmental Cricket Tournament
• Featured Fellow: Dr. Shahid Khan
• Poem Section
• What Academics Are Reading

Essays On The Determinants Of Women's And Children's Health In Bangladesh, Md Shahjahan

USF Tampa Graduate Theses and Dissertations

My dissertation is titled "The Determinants of Women's and Children's Health in Bangladesh." The first chapter studies the impact of a Bangladeshi schooling program on child immunization rates. The program provided a stipend and other incentives to attend secondary school, significantly increasing rural girls' education. I hypothesize that this would lead to higher immunization rates in the next generation since better-educated mothers have better knowledge of health practices. The study uses a regression model ("difference-in-differences"), which is based on differential exposure to the 1994 Female Secondary School Stipend Program (FSSSP) by birth cohort and rural residence. I find that the …

Ecosystem Sentinels As Early-Warning Indicators In The Anthropocene, Elliott L. Hazen, Matthew S. Savoca, T.J. Clark-Wolf, Max Czapanskiy, Peter M. Rabinowitz, Briana Abrahms

Wildland Resources Faculty Publications

We are already experiencing the rapid pace of environmental perturbation in the Anthropocene, necessitating the development of new tools and techniques for measuring changes in ecosystem dynamics. Sentinel species, from birds to invertebrates, have been used to provide insights into ecosystem function, as leading indicators of risk to human health and as harbingers of future change, with implications for ecosystem structure and function. Here, we offer an update to previous research identifying marine top predators as indicators of ecosystem shifts and examine terrestrial sentinels and the latest research on sentinels of pollution and human health. Using ecosystem sentinels enables rapid …

Preparing For The Next Pandemic: Helpful Strategies For Hospital Managers, Lynesha Sweeney

Walden Dissertations and Doctoral Studies

During the rapid spread of the coronavirus in 2020, some hospital managers lacked strategies to support and treat the number of patients falling ill daily. Effective strategies to support and treat patients during the next pandemic are important to hospital managers because insufficient access to quality healthcare services can be harmful to community citizens and detrimental to hospital sustainability. Grounded in the resource-based theory, the purpose of this qualitative pragmatic inquiry was to explore strategies some hospital managers have created and implemented to be prepared for future pandemics within their facilities. The participants were six healthcare leaders working in roles …

Preparing For The Next Pandemic: Helpful Strategies For Hospital Managers, Lynesha Sweeney

Walden Dissertations and Doctoral Studies

During the rapid spread of the coronavirus in 2020, some hospital managers lacked strategies to support and treat the number of patients falling ill daily. Effective strategies to support and treat patients during the next pandemic are important to hospital managers because insufficient access to quality healthcare services can be harmful to community citizens and detrimental to hospital sustainability. Grounded in the resource-based theory, the purpose of this qualitative pragmatic inquiry was to explore strategies some hospital managers have created and implemented to be prepared for future pandemics within their facilities. The participants were six healthcare leaders working in roles …

Seroprevalence Of Anti-Sars-Cov-2 Igg Antibodies In Healthcare Personnel In El Salvador Prior To Vaccination Campaigns, José Elías Aguilar Ramírez, Adrianna Maliga, Allison Stewart, Allison Lino, José Eduardo Oliva, Xochitl Sandoval, Emily Zielinski-Gutierrez, Rafael Chacon-Fuentes, Parminder S Suchdev, Susana Zelaya, Mario Sánchez, Delmy Lisseth Recinos, Beatriz López, Ella Hawes, Julie Liu, Shannon E Ronca, Sarah M Gunter, Kristy O Murray, Rhina Domínguez

Faculty, Staff and Students Publications

COVID-19, caused by the SARS-CoV-2 virus, is a highly pathogenic emerging infectious disease. Healthcare personnel (HCP) are presumably at higher risk of acquiring emerging infections because of occupational exposure. The prevalence of COVID-19 in HCP is unknown, particularly in low- to middle-income countries like El Salvador. The goal of this study was to determine the seroprevalence of anti-SARS-CoV-2 antibodies among HCP in El Salvador just prior to vaccine rollout in March 2021. We evaluated 2176 participants from a nationally representative sample of national healthcare institutions. We found 40.4% (n = 880) of the study participants were seropositive for anti-spike …

A Meta-Ensemble Predictive Model For The Risk Of Lung Cancer, Sideeqoh Oluwaseun Olawale-Shosanya, Olayinka Olufunmilayo Olusanya, Adeyemi Omotayo Joseph, Kabir Oluwatobi Idowu, Oyelade Babatunde Eriwa, Adedeji Oladimeji Adebare, Morufat Adebola Usman

Al-Bahir

The lungs play a vital role in supplying oxygen to every cell, filtering air to prevent harmful substances, and supporting defense mechanisms. However, they remain susceptible to the risk of diseases such as infections, inflammation, and cancer that affect the lungs. Meta-ensemble techniques are prominent methods used in machine learning to enhance the accuracy of classifier learning systems in making predictions. This work proposes a robust predictive model using a meta-ensemble method to identify high-risk individuals with lung cancer, thereby taking early action to prevent long-term problems benchmarked upon the Kaggle Machine Learning practitioners' Lung Cancer Dataset. Three machine learning …

Noda News December 2017

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News April 2018

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News March 2018

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News February 2018

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News January 2018

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Nine Years Of Banding At Four Areas In New Jersey, Eastern Bird Banding Association News

Eastern Bird Banding Association News

No abstract provided.

Nine Years Of Bird Banding At Four Areas In New Jersey: Iv Corvidae And Paridae, Raymond E. Kerlin, William C. Carter, Oscar Sussman, Martin Goldfield

Eastern Bird Banding Association News

No abstract provided.

Nine Years Of Bird Banding At Four Areas In New Jersey (Part Iii), William C. Carter, Raymond E. Kerlin, Oscar Sussman, Martin Goldfield

Eastern Bird Banding Association News

No abstract provided.

News In Brief, Eastern Bird Banding Association News

Eastern Bird Banding Association News

No abstract provided.

Medical School Watercooler Newsletter - June 6, 2024, Lindsey Lyle

Watercooler Newsletter

This is the June 6, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• USA Health cardiology fellows earn American College of Cardiology awards
• USA student researcher accepted into prestigious national honor society
• Sarkar appointed to BCRFA Medical Advisory Council
• Summer research program kicks off at Whiddon COM

Creating A Capital-Efficient Organization: Accele Biopharma, Jesse Lee Brown, Tyechia Paul

College of Business and Economics

Research methodology

Case information was mainly acquired through interviews with Richard Gammans, chief operating officer. Dr Gammans was a visiting professor at Fayetteville State University for a year, and two of the case authors developed personal friendships with Richard. Interviews were conducted over a two-year period as the accelerator got started. In addition, one author conducted a team-building session with the management team and one of the bio-startup researchers. An interview was also conducted with Clayton Duncan, chief executive officer, to gain his agreement with developing the case.

The Accele website included a write-up on each of the pharmaceutical startup …

Editorial: Management Of Pji/Ssi After Joint Arthroplasty, Li Cao, Javad Parvizi, Xiaogang Zhang, Xianzhe Liu, Wierd Zijlstra, Saad Tarabichi

Rothman Institute Papers

The management of periprosthetic joint infection (PJI) and surgical site infection (SSI) after joint arthroplasty poses a major challenge in orthopedic surgery. This Editorial provides an overview of the studies published in the special issue "Management of PJI/SSI after Joint Arthroplasty", summarizing the key findings from these studies, which cover a wide range of topics, including stringent preventive strategies, comprehensive diagnostic methods, and personalized treatment modalities. The authors concluded the editorial with their perspectives regarding the status quo of research in this field and future directions for research, such as the development of novel antibiotics, biofilm research, patient-specific risk factors, …

Global Health Problems In New Mexico: Resources In Hslic Special Collections, Deborah J. Rhue, Abbie Weiser Olivas

Posters and Presentations

This online talk by Abbie Olivas, HSLIC Archivist, and Deborah Rhue, HSLIC Clinical Services Librarian explored archival resources in Special Collections that further our understanding of global health problems, such as diabetes, tuberculosis, HIV/AIDS, and the plague. This event was in conjunction with the National Library of Medicine's traveling exhibit, Making a World of Difference: Stories about Global Health, on display on the Library's 4th floor from June 3 - July 13, 2024.