Digital Commons Network^™

Residential Older Adults’ Experiences Related To Mental Health From Covid-19 Isolation, Heidi Beth Lubetkin

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic exacerbated many illnesses afflicting older adults in U.S. communities, including mental health wellness. Since 2020, at the inception of the pandemic, older adults living in residential settings, including assisted living and skilled nursing homes, experienced harsh limitations in their everyday lives. The conditions included prolonged periods of isolation and reduced interactions between caregivers and loved ones. Therefore, it is important to understand the experiences of older adults living in facilities and their ability to adapt to the environment. The research question addressed in this study gained insight into the effects of mandated isolation on older adults. Using …

Synthetic Assembly Of Antibacterial Agents And Metal Chelating Ligands, Zachary Joseph Liveris

Dissertations

The exploitation of chemical synthesis exemplifies the notion of bridging both innovation and curiosity for the strategic assembly of sophisticated molecular infrastructures. By exerting this continuously evolving and versatile tool, synthesis has been applied in the development and influence of a myriad of ligands, biological probes, and persists to direct pharmaceutical innovation and modern medicine alike. Since pathogenic multidrug-resistant (MDR) microbial strains remain to be a persistent threat to both clinical healthcare and society, the need to develop selective and efficacious antibacterial agents that can impede microbe pathogenicity and regulate cellular mortality is paramount. In contrast to pharmaceutical development, organic …

A Qualitative Descriptive Study Of Therapists And Their Work With Socially Isolated Female Victims Of Sexual Violence Amid The Covid-19 Pandemic, Iris Lazette Saldivar

Doctoral Dissertations and Projects

The purpose of this qualitative descriptive study was to assess the experiences of therapists and the descriptions of their navigation processes while working with female victims of sexual violence who were socially isolated during the COVID-19 pandemic in the state of Texas. The theory that guided this study was the theoretical framework of loneliness, social isolation, and associated health outcomes. The research study focuses on two research questions that sought to examine the experiences and navigation of virtual treatment of therapists who provided counseling during the COVID-19 pandemic from March 2020 to March 2022. This study sought to find a …

Effect Of Incarceration On Prisoners Diagnosed With Mental Health Conditions: Trauma, Treatment, And Transitioning, Ingria S. Haywood

Doctoral Dissertations and Projects

A mental illness is a medical disorder that affects a person’s behavior, thoughts, and emotions. It also has an impact on social and cognitive functions. Misuse of substances, biological factors, or abuse, whether as a victim or a bystander to repeated abuse, are all variables that contribute to mental illness. The prevalence of mental illness among incarcerated prisoners is alarming, and it is nondiscriminatory in that it affects both men and women. Several variables contribute to inmates’ susceptibility to mental health problems. Anxiety disorders, depression as a mood disorder, dementia, and schizophrenia are examples of these. A diagnosis of mental …

Around The Center, 1994 April/May, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and features on the annual meeting and the sleep disorder clinic.

Identifying Overdose Risk Factors For People Hospitalized With Injection Drug Use-Associated Infections In Maine, Melanie Mait, Kim Murray, Tania D. Strout, Kinna Thakarar

Journal of Maine Medical Center

Introduction: The overdose crisis continues to be a significant problem, particularly in rural states such as Maine. The objectives of this study were to: 1) describe demographic and health characteristics and 2) identify overdose risk factors among people in Maine hospitalized with injection drug use (IDU)-associated infections.

Methods: We performed descriptive analysis of demographics, health characteristics, and injection practices, stratified by lifetime history of overdose. We conducted an exploratory logistic regression analysis, controlling for gender, homelessness, having experienced an emergency department (ED) visit in the past 3-months, and endorsement of injecting alone in the past 30 days to examine …

Repeat Controlled Human Plasmodium Falciparum Infections Delay Bloodstream Patency And Reduce Symptoms, Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Faculty, Staff and Student Publications

Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the maturation of the host response against controlled repeat exposures to P. falciparum (Pf) NF54 strain-infected mosquitoes, we systematically monitored malaria-naïve participants through an initial exposure to uninfected mosquitoes and 4 subsequent homologous exposures to Pf-infected mosquitoes over 21 months (n = 8 males) (ClinicalTrials.gov# NCT03014258). The primary outcome was to determine whether protective immunity against parasite infection develops following repeat CHMI and the secondary outcomes were to track the clinical signs and symptoms of malaria and anti-Pf antibody …

Author Correction: Il-12 Reprograms Car-Expressing Natural Killer T Cells To Long-Lived Th1-Polarized Cells With Potent Antitumor Activity, Elisa Landoni, Mark G Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M Flick, Tracy A Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

No abstract provided.

Evolution Of Global Anatomy Research Through Covid-19: A Post-Pandemic Evaluation, Harsh Chheda, Santanu De

FDLA Journal

The Coronavirus Infectious Disease 2019 (COVID-19) struck the world with a deep impact on many countries' healthcare systems. More specifically, anatomical research experienced a drastic setback due to the limitations and restrictions placed upon them by the medical community. This study aims to review how COVID-19 guidelines presented conflict regarding the retrieval and use of cadavers, as well as how anatomy research was modified on a global scale owing to the pandemic. The COVID-19 outbreak called for several changes upon each significant anatomical research technique, ranging from cadaver dissection to diagnostic imaging. Given the remarkable shift in medical research guidelines …

Global Implications Of Covid-19 On Education And Research In Healthcare And Stem: Analysis Of Case Studies, Yumna Indorewala, Santanu De

FDLA Journal

The zoonotic novel coronavirus, SARS-CoV-2 posed major threats to the world’s economy, social development, and public health. Education and research in STEM and healthcare were no exceptions to the global implications of the Coronavirus Infectious Disease 2019 (COVID-19) pandemic. Social distancing guidelines were initially recommended to refrain from in-person operations for preventing the transmission of the virus. As academic organizations implemented multifarious methods to effectively transition to remote/online or hybrid educational formats, COVID-19 necessitated designing, adopting, as well as evaluating the efficacy of new instructional approaches, especially for disciplines that require active, experiential learning such as healthcare and STEM. These …

The Relationship Between Magnet And Non-Magnet Designated Sites And Severe Maternal Morbidity For New Jersey Hospitals, Adrienne L. Elberfeld

Walden Dissertations and Doctoral Studies

For the past 25 years U.S. health care providers have reported higher than expected severe maternal morbidity (SMM). Magnet status is a designation through the American Nurses Credentialing Center (ANCC). Studies indicate that hospitals with Magnet recognition provide better patient care resulting in better quality outcomes. The recent COVID-19 pandemic (COVID-19) created a global-wide disruption, presenting new systemic challenges for U.S. health care providers in providing accessible, timely patient health services. The purpose of this study was to determine if there is a statistically significant difference between Magnet and non-Magnet hospitals in New Jersey (NJ) for SMM rates during COVID-19 …

Pharmacy Federal Grant To Propel Vaccine Technology Research, Natalie Ehrhardt

University of Mississippi News

OXFORD, Miss. – The U.S. Food and Drug Administration has awarded some $500,000 to University of Mississippi pharmacy professor Mo Maniruzzaman, with a recommendation for another $500,000 in 2025, to develop a technology that promises to streamline vaccine production.

The Relationship Between Magnet And Non-Magnet Designated Sites And Severe Maternal Morbidity For New Jersey Hospitals, Adrienne L. Elberfeld

Walden Dissertations and Doctoral Studies

For the past 25 years U.S. health care providers have reported higher than expected severe maternal morbidity (SMM). Magnet status is a designation through the American Nurses Credentialing Center (ANCC). Studies indicate that hospitals with Magnet recognition provide better patient care resulting in better quality outcomes. The recent COVID-19 pandemic (COVID-19) created a global-wide disruption, presenting new systemic challenges for U.S. health care providers in providing accessible, timely patient health services. The purpose of this study was to determine if there is a statistically significant difference between Magnet and non-Magnet hospitals in New Jersey (NJ) for SMM rates during COVID-19 …

Exploring The Experiences Of Hiv Positive Pregnant Women On Prevention Of Vertical Transmission Of Hiv/Aids In Rural Malawi, Gertrude Finyiza

Electronic Theses and Dissertations

Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) continues to be the primary conduct that HIV is transmitted to children worldwide. The problem of HIV/acquired immunodeficiency syndrome (AIDS) is having a great impact on the world's children. The prevalence of HIV/AIDS in Malawi continues to be a serious public health issue, especially for expectant mothers. The health outcomes of mothers and children remain significantly threatened by vertical HIV transmission, even with improvements in preventive and treatment efforts. The purpose of this thesis was to explore the experiences of HIV-positive pregnant women in Malawi. I conducted semi structured interviews with thirteen …

Establishment Of A Research Site At The Kennedy Mountain Campus For The Observation Of Airborne Particulate Matter, Alyssa Knaus

Undergraduate Theses, Capstones, and Recitals

This thesis explored particulate matter (PM) concentrations at two sites within the Colorado Front Range. The study utilized two models of PurpleAir PM sensors, Flex and SD-II, to provide real-time, accessible data on PM1, PM2.5, and PM10 mass concentrations with the goal of establishing the first research site at the Kennedy Mountain Campus (KMC). The first of the two sites used during this study was at a suburban location outside of Denver, CO. This period was used as an instrument intercomparison period in order to conduct instrument analysis. The initial findings from this period found significant correlations between PM concentration …

Anomalous Presentation And Endoscopic Findings Of Acute Esophageal Necrosis: A Case Report, Ahmed Shehadah, Abdullah A. Orakzai, Sheza Malik, Alshaima Yousef, Ali Jaan, Patrick Okolo

Advances in Clinical Medical Research and Healthcare Delivery

Introduction:

Acute esophageal necrosis (AEN), is a rare disorder with an estimated incidence of 0.01-0.28%. It typically affects the distal third of the esophagus. Approximately 90% of patients with acute esophageal necrosis present with upper gastrointestinal (GI) bleeding, primarily due to ischemic insult or severe hemodynamic compromise. In this report, we describe a case in which the patient presented with odynophagia and dysphagia, but without upper GI bleeding. The patient exhibited pan mucosal involvement of the esophagus, which extended to the gastric antrum.

Case: A 55-year-old man with a history of type 2 diabetes mellitus and substance abuse presented with …

Perspectives On Computational Modeling Of Biological Systems And The Significance Of The Sysmod Community, Bhanwar Lal Puniya, Meghna Verma, Chiara Damiani, Shaimaa Bakr, Andreas Dräger

Department of Biochemistry: Faculty Publications

Motivation: In recent years, applying computational modeling to systems biology has caused a substantial surge in both discovery and practical applications and a significant shift in our understanding of the complexity inherent in biological systems.

Results: In this perspective article, we briefly overview computational modeling in biology, highlighting recent advancements such as multiscale modeling due to the omics revolution, single-cell technology, and integration of artificial intelligence and machine learning approaches. We also discuss the primary challenges faced: integration, standardization, model complexity, scalability, and interdisciplinary collaboration. Lastly, we highlight the contribution made by the Computational Modeling of Biological Systems …

Persistent Gram-Negative Bloodstream Infection Increases The Risk Of Recurrent Bloodstream Infection With The Same Species, Paa Kwesi Ankrah, Andrew Bock, Felicia Ruffin, Blake M Hanson, Cesar A Arias, Stacey A Maskarinec, Joshua Parsons, Vance G Fowler, Joshua T Thaden

Faculty, Staff and Student Publications

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; P = .04). Persistent GN-BSI may be a marker of complicated infection.

Evaluating The Influence Of Perfluorooctane Sulfonic Acid Exposure On Blood Glucose Levels: A Comprehensive Multiple Regression Analysis Considering Confounding Factors, Henry Mensah

Theses and Dissertations

Perfluorooctane sulfonate (PFOS) are widely used for industrial and commercial purposes and have received increasing attention due to their adverse effects on health. This thesis investigates the relationship between PFOS exposure and blood glucose levels, considering potential confounding factors. Regression analysis was conducted on a dataset comprising demographic, lifestyle, and biomarker data from a diverse population sample. Sex exhibited a significant role, with females demonstrating an 11.77% increase in blood glucose levels in response to PFOS exposure compared to males, supported by a p-value of 1.04 × 109. Body mass index (BMI) also played a pivotal role, revealing a 2.17% …

Elementary School Teachers’ Lived Experience Teaching Remotely During The Covid-19 Pandemic, Natasha Gorman

Walden Dissertations and Doctoral Studies

Teaching experiences changed during COVID-19 from face-to-face to online, and teachers encountered numerous challenges. Considerable research has been conducted on many of the issues that teachers at different grade levels faced in this transition. The experiences of elementary school teachers, however, have not received much attention. The purpose of this qualitative study was to explore the lived experiences of elementary school teachers who taught remotely during the COVID-19 pandemic. Understanding their challenges may lead to the development of appropriate resources and specific training for teachers in these early grades. The theoretical foundation that grounded this study was Bronfenbrenner’s ecological systems …

Persistent Gram-Negative Bloodstream Infection Increases The Risk Of Recurrent Bloodstream Infection With The Same Species, Paa Kwesi Ankrah, Andrew Bock, Felicia Ruffin, Blake M Hanson, Cesar A Arias, Stacey A Maskarinec, Joshua Parsons, Vance G Fowler, Joshua T Thaden

Faculty, Staff and Student Publications

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; P = .04). Persistent GN-BSI may be a marker of complicated infection.

Update On Outbreak Of Fungal Meningitis Among Us Residents Who Received Epidural Anesthesia At Two Clinics In Matamoros, Mexico, Dallas J Smith, Jeremy A W Gold, Tom Chiller, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Vladimir Brian Gonzalez Cortes, Celida Duque Molina, Samantha Williams, Axel A Vazquez Deida, Katrina Byrd, Peter G Pappas, Thomas F Patterson, Nathan P Wiederhold, George R Thompson, Luis Ostrosky-Zeichner

Faculty, Staff and Student Publications

Background: Public health officials are responding to an outbreak of fungal meningitis among patients who received procedures under epidural anesthesia at 2 clinics (River Side Surgical Center and Clinica K-3) in Matamoros, Mexico, during 1 January to 13 May 2023. This report describes outbreak epidemiology and outlines interim diagnostic and treatment recommendations.

Methods: Interim recommendations for diagnosis and management were developed by the Mycoses Study Group Research Education and Consortium (MSGERC) based on the clinical experience of clinicians caring for patients during the current outbreak or during previous outbreaks of healthcare-associated fungal meningitis in Durango, Mexico, and the United States. …

Current And Future Environmental Suitability For Bats Hosting Potential Zoonotic Pathogens In Rural Kenya, Ruut Uusitalo, Reilly T. Jackson, Tamika J. Lunn, Essi M. Kohonen, Joseph G. Ogala, Paul W. Wabala, Tarja A. Sironen, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

Synanthropic bats live in close proximity to humans and domestic animals, creating opportunities for potential pathogen spillover. We explored environmental correlates of occurrence for a widely distributed synanthropic African bat, Mops pumilus—a species associated with potential zoonotic viruses—and estimated current and future environmental suitability in the Taita Hills region and surrounding plains in Taita–Taveta County in southeast Kenya. To project future environmental suitability, we used four Coupled Model Intercomparison Project Phase 6 general circulation models that capture temperature and precipitation changes for East Africa. The models were parameterized with empirical capture data of M. pumilus collected …

A Randomized, Double-Blind, Phase 3 Safety And Efficacy Study Of Ridinilazole Versus Vancomycin For Treatment Of Clostridioides Difficile Infection: Clinical Outcomes With Microbiome And Metabolome Correlates Of Response, Pablo C Okhuysen, Erik R Dubberke, Et Al.

2020-Current year OA Pubs

BACKGROUND: Exposure to antibiotics predisposes to dysbiosis and Clostridioides difficile infection (CDI) that can be severe, recurrent (rCDI), and life-threatening. Nonselective drugs that treat CDI and perpetuate dysbiosis are associated with rCDI, in part due to loss of microbiome-derived secondary bile acid (SBA) production. Ridinilazole is a highly selective drug designed to treat CDI and prevent rCDI.

METHODS: In this phase 3 superiority trial, adults with CDI, confirmed with a stool toxin test, were randomized to receive 10 days of ridinilazole (200 mg twice daily) or vancomycin (125 mg 4 times daily). The primary endpoint was sustained clinical response (SCR), …

Elementary School Teachers’ Lived Experience Teaching Remotely During The Covid-19 Pandemic, Natasha Gorman

Walden Dissertations and Doctoral Studies

Teaching experiences changed during COVID-19 from face-to-face to online, and teachers encountered numerous challenges. Considerable research has been conducted on many of the issues that teachers at different grade levels faced in this transition. The experiences of elementary school teachers, however, have not received much attention. The purpose of this qualitative study was to explore the lived experiences of elementary school teachers who taught remotely during the COVID-19 pandemic. Understanding their challenges may lead to the development of appropriate resources and specific training for teachers in these early grades. The theoretical foundation that grounded this study was Bronfenbrenner’s ecological systems …

A Phase 2 Clinical Trial To Evaluate The Safety, Reactogenicity, And Immunogenicity Of Different Prime-Boost Vaccination Schedules Of 2013 And 2017 A(H7n9) Inactivated Influenza Virus Vaccines Administered With And Without As03 Adjuvant In Healthy Us Adults, Christina A Rostad, Robert L Atmar, Emmanuel B Walter, Sharon Frey, Jeffery L Meier, Amy C Sherman, Lilin Lai, Rachel Tsong, Carol M Kao, Vanessa Raabe, Hana M El Sahly, Wendy A Keitel, Jennifer A Whitaker, Michael J Smith, Kenneth E Schmader, Geeta K Swamy, Getahun Abate, Patricia Winokur, Wendy Buchanan, Kaitlyn Cross, Ashley Wegel, Yongxian Xu, Inci Yildirim, Satoshi Kamidani, Nadine Rouphael, Paul C Roberts, Mark J Mulligan, Evan J Anderson

Center for Medical Ethics and Health Policy Staff Publications

Introduction: A surge of human influenza A(H7N9) cases began in 2016 in China from an antigenically distinct lineage. Data are needed about the safety and immunogenicity of 2013 and 2017 A(H7N9) inactivated influenza vaccines (IIVs) and the effects of AS03 adjuvant, prime-boost interval, and priming effects of 2013 and 2017 A(H7N9) IIVs.

Methods: Healthy adults (n = 180), ages 19-50 years, were enrolled into this partially blinded, randomized, multicenter phase 2 clinical trial. Participants were randomly assigned to 1 of 6 vaccination groups evaluating homologous versus heterologous prime-boost strategies with 2 different boost intervals (21 vs 120 days) and 2 …

Viral And Host Factors Are Associated With Mortality In Hospitalized Patients With Covid-19, Neil R Aggarwal, Jacquie Nordwall, Dominique L Braun, Lucy Chung, Jordan Coslet, Tatyana Der, Nnakelu Eriobu, Adit A Ginde, Awori J Hayanga, Helene Highbarger, Mark Holodniy, Juan P Horcajada, Mamta K Jain, Kami Kim, Sylvain Laverdure, Jens Lundgren, Ven Natarajan, Hien H Nguyen, Sarah L Pett, Andrew Phillips, Garyphallia Poulakou, David A Price, Philip Robinson, Angela J Rogers, Uriel Sandkovsky, Katy Shaw-Saliba, Jeffrey M Sturek, Barbara W Trautner, Michael Waters, Cavan Reilly

Faculty, Staff and Students Publications

BACKGROUND: Persistent mortality in adults hospitalized due to acute COVID-19 justifies pursuit of disease mechanisms and potential therapies. The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) trials.

METHODS: A secondary analysis of 2625 adults hospitalized for acute SARS-CoV-2 infection randomized to 1 of 5 antiviral products or matched placebo in 114 centers on 4 continents. Uniform, site-level collection of participant baseline clinical variables was performed. Research laboratories assayed baseline upper respiratory swabs for SARS-CoV-2 viral RNA and plasma for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleocapsid …

Mathematical Modeling Of An Epidemic In Scale-Free Network With Imperfect Vaccination, Heba Hameed

Thesis/ Dissertation Defenses

In light of the recent COVID-19 pandemic, the mathematical epidemiological model has proven to be essential for understanding the disease dynamic and finding the best control tool to help contain the disease and minimize its impact. This thesis investigates the dynamics of an infectious disease spread with latent infection and vaccination. The aim is to study this model's dynamic in a network that reflects the heterogeneity of the environment where the disease spreads. The vaccination is assumed to be not perfect, which means that vaccinated persons are likely to be infected and that the vaccinated person could lose their immunity, …

Mash: Advances In Treatment And Triage During The Korean War, Ryan Planer

Chronos

No abstract provided.

Housing Affordability: Determining The Percentage Of Working-Class Millennials To Afford Renting A Studio-Type Condominium In Bonifacio Global City, Johara B. Piega, Ricardo Cholo L. Santos

DLSU Senior High School Research Congress

Proper housing is vital for sustainable environments and for an individual’s well-being — providing security, emotional stability, and a sense of belonging. However, the Philippines faces challenges in providing affordable shelter, especially as it has remained in the lower-middle income bracket alongside other Southeast Asian countries for over three decades. Bonifacio Global City (BGC) stands as Metro Manila’s premier business district and contributes to the affordability for housing in the country. This study focuses on the affordability of studio-type condominiums in BGC for working-class Millennials aged 28-43. Conducted through quantitative research methods and a descriptive design, it employed snowball and …