Digital Commons Network^™

Around The Center, 1999 July, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on an upcoming Joint Commission on the Accreditation of Healthcare Organizations (JCAHO).

Around The Center, 1999 August/September, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the renovated Surgical Intensive Care Unit.

Around The Center, 2000 April/May, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the upcoming merger with Advocate Health Care.

“Siguiendo Adelante”/ "Moving Forward:" Gender-Based Violence (Gbv) Service-Seeking And Survivorship Among Indigenous Guatemalan Women, Caitlynn C. Carr

USF Tampa Graduate Theses and Dissertations

This dissertation examines Indigenous women’s access to and beliefs regarding gender-based violence (GBV) services and the Guatemalan legal system. It illuminates the legal, structural, and institutional challenges and power dynamics associated with seeking support and justice for women in Guatemala, as well as why and how women decide to seek formal assistance. This research also investigates changes in attitudes and beliefs regarding women’s rights, gender roles, and formal and informal forms of support for GBV survivors. Utilizing a mixed-methods, engaged anthropological approach during 10 months of ethnographic fieldwork in two primary locations in Guatemala, this dissertation explicates qualitative data collected …

Using Living Labs To Engage Communities And Stakeholders In The Development And Knowledge Exchange Of Urban Health And Sanitation Solutions In The Global South, Emmanuel Tsekleves, Roger Pickup, Manoj Roy

DRS Biennial Conference Series

Engaging communities and stakeholders in developing user-centred urban health solutions, whilst linking the research to their own development, pose major challenges for design researchers working in the Global South. In a number of circular sanitation projects in a community school in Ghana, we co-designed and installed an anaerobic digester delivering electricity and sanitation improvements. To enhance impact we developed and pilot-tested a Living and physical Lab design approach. One project focussed on hand hygiene. We introduced students to ‘making the invisible visible’ by visualising microbes from their hands and assessing handwashing effects. Our findings suggest that visualisation of microbes not …

Fostering A Patient-Led Culture Of Care Through Data Physicalization: A Design Approach To Create Awareness And Promote Data Collection On Antimicrobial Resistance, Ginevra Terenghi, Serena Cangiano, Antonella Autuori, Cristina Margarida Corti

DRS Biennial Conference Series

The paradigm shift in healthcare delivery models is leading to individuals assuming greater responsibilities and control, as the agency is moving from doctor-centric to patient-centric. To foster a patient-led culture of care, health and data literacy are essential, especially in the context of global challenges, where citizen awareness is fundamental to play actively in co-creating knowledge. This paper outlines a methodological approach and the outcomes of a design research project focused on promoting engagement and literacy to facilitate citizen and patient participation in addressing the antimicrobial resistance threat. The approach is tested in the format of an experimental workshop, inspired …

Reimagining Antibiotic Delivery At Home: Designing A Wearable Cool-Infuser, Geoffrey Thompson, Rowan Page, Benjamin Rogers

DRS Biennial Conference Series

As antimicrobial resistance (AMR) intensifies, hospitals face increased pressure due to the high demand for bed spaces and the associated risks of hospital-acquired infections. Outpatient Antimicrobial Therapy (OPAT) offers a solution by enabling patients to receive life-saving intravenous antibiotic treatments in the community rather than in hospitals. However, temperature-sensitive antibiotics can degrade when exposed to heat, creating design challenges in OPAT settings. Current antibiotic infusion devices focus on the clinical need and outcomes of treatment, leaving room to improve the holistic patient experience of living with the device. Through a human-centred design approach, this project develops a Wearable cool-infuser that …

Reimagining Patient-Centered Multimedia Distraction Strategies In The Emergency Department, India Star Macpherson, Rowan Christopher Page, Lisa Kuhn, Daphne Flynn, Gabriel Blecher

DRS Biennial Conference Series

This paper investigates the application of immersive multimedia tools as an effective means of distraction in Emergency Departments (ED). With a focus on ageing populations exhibiting Acute Behavioural Disturbance (ABD) and the aim of reducing the reliance on psychotropic medications and sedatives. The study explores the use of immersive multimedia for distraction using readily available technology (VR headsets, curved displays, and 360-degree video on tablets). Consumer devices were customised through co-design collaboration with experienced ED clinicians to adapt to the unique challenges of the ED environment. Thirteen participants, representing the target demographic, were engaged in usability and user-acceptance testing and …

A Participatory Approach To Healthcare Service Improvement Focused On Staff Behavior Change, Fernando Carvalho, Val Mitchell, Gyuchan Thomas Jun

DRS Biennial Conference Series

Healthcare systems are complex social systems wherein improvements related to staff practice and behavior can be difficult to implement. Knowledge and practice can be uneven between various specializations, hierarchical imbalances limit the degree of agency of different professionals, and evidence-based guidelines may be interpreted or implemented according to context-specific factors. When changes are imposed from a top-down perspective, invaluable insight and know-how from frontline staff are usually left out, making it further difficult (if not altogether impractical) to implement interventions. The current paper presents a case study focused on improving urinary tract infection diagnosis and treatment, in the emergency department …

Event Booklet (Pdf), Department Of Orthopaedic Surgery

Dept. of Orthopaedics: Robert D. D’Ambrosia Lectureship & Research Day

No abstract provided.

Pilgrimage In The Covid-19 Era: Uncovering Supply Side Challenges And Opportunities In Media Representations, Reni Polus, Ismail Shaheer, Naresh P. Nayak

International Journal of Religious Tourism and Pilgrimage

Pilgrimage travel, a common practice across major religions, has historically exhibited remarkable resilience to global crises, owing to the unwavering conviction of its followers. However, the COVID-19 pandemic marked a significant departure from this trend, disrupting pilgrimage tourism, unlike any event since World War II. Despite extensive research on the pandemic’s impact on tourism, limited attention has been directed towards understanding its specific effects on pilgrimage travel. This study seeks to address this gap by examining the challenges and opportunities faced by pilgrimage tourism suppliers in the aftermath of COVID-19. To obtain a comprehensive global perspective, we collected and analysed …

The Academic Influence Of The Camino De Santiago: A Bibliometric Analysis Of Doctoral Research And Indexed Manuscripts, Silvia Díaz-De La Fuente, Virginia Ahedo, María Pilar Alonso Abad, José Manuel Galán

International Journal of Religious Tourism and Pilgrimage

The Camino de Santiago is one of the most recognised cultural pilgrimage routes in the world. Notably, its current influence transcends the strictly inspirational and religious aspects, constituting also a socio-economic, cultural, historical, heritage and tourism cornerstone. This paper analyses, from an innovative bibliometric perspective, the influence of the Camino de Santiago on the academic literature in the period from 1980 to the present. For this purpose, two data sources have been used comparatively: manuscripts indexed in Scopus and doctoral theses. The results reveal a growth of its academic relevance in the last decade, especially in indexed publications. The analysis …

Novel Adaptations In Iron Regulation Acquired During Chronic Fungal Cf Infections, Daniel R. Murante

Dartmouth College Ph.D Dissertations

Chronic fungal infections are highly recalcitrant to treatment; we postulated that as populations persist, increasing genetic diversity is reflected in phenotypic heterogeneity, contributing to treatment inefficacies. The study of evolutionary patterns is underrepresented in chronic fungal infections, and to supplement this body of knowledge, we leveraged isolates acquired from four individuals with chronic fungal-dominated cystic fibrosis infections. We evaluated in-host evolution through a whole-genome sequencing approach, comparing multiple isolates obtained from each subject's sputum and bronchoalveolar lavage fluid. Our analysis found non-synonymous mutations that arose in parallel across the independent infections in the gene MRS4, which encodes a mitochondrial …

Application And Development Of Ceragenins In Medical Device Coatings For Clinical Settings, Elliot E. Sherren

Theses and Dissertations

Hospital-acquired infections (HAIs) pose a significant and increasing threat to global health. One primary cause of this threat is increasing antibiotic resistance. As traditional antibiotics continue to grow less effective, there is an urgent need for novel antimicrobial strategies. This work explores the potential of ceragenins, also known as cationic steroid antimicrobials (CSAs), as a promising alternative to combat HAIs. Specifically, we investigated potential roles that CSAs can play in the context of multiple medical device coatings in healthcare settings. Ceragenins are synthetic mimic of antimicrobial peptides (AMPs) which exhibit broad-spectrum antimicrobial activity against many common pathogens that have been …

The Association Between Mental Health And Fibromyalgia In African Americans, Shalika J. Tisinger

Walden Dissertations and Doctoral Studies

Depression and fibromyalgia can often exacerbate each other and are known to be bidirectional disorders. Chronic pain from fibromyalgia often leads to depression, and depression can cause pain to become worse and affect the nervous system, causing pain. The purpose of this quantitative, binary logistic regression study is to determine if there is an association between mental health and fibromyalgia in African Americans while controlling for cardiovascular disease, chronic kidney disease, arthritis, education level (ie. Some high school, high school graduate, some college or higher), diet, poverty-income-ratio, PIR, diabetes, gender, and age. The socio-ecological model included in this cross-sectional study …

Elucidating Immune-Related Gene Transcriptional Programs Via Factorization Of Large-Scale Rna-Profiles, Shan He, Matthew M Gubin, Hind Rafei, Rafet Basar, Merve Dede, Xianli Jiang, Qingnan Liang, Yukun Tan, Kunhee Kim, Maura L Gillison, Katayoun Rezvani, Weiyi Peng, Cara Haymaker, Sharia Hernandez, Luisa M Solis, Vakul Mohanty, Ken Chen

Faculty, Staff and Student Publications

Recent developments in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy (ACT), have encountered challenges such as immune-related adverse events and resistance, especially in solid tumors. To advance the field, a deeper understanding of the molecular mechanisms behind treatment responses and resistance is essential. However, the lack of functionally characterized immune-related gene sets has limited data-driven immunological research. To address this gap, we adopted non-negative matrix factorization on 83 human bulk RNA sequencing (RNA-seq) datasets and constructed 28 immune-specific gene sets. After rigorous immunologist-led manual annotations and orthogonal validations across immunological contexts and functional omics data, we demonstrated …

The Association Between Mental Health And Fibromyalgia In African Americans, Shalika J. Tisinger

Walden Dissertations and Doctoral Studies

Depression and fibromyalgia can often exacerbate each other and are known to be bidirectional disorders. Chronic pain from fibromyalgia often leads to depression, and depression can cause pain to become worse and affect the nervous system, causing pain. The purpose of this quantitative, binary logistic regression study is to determine if there is an association between mental health and fibromyalgia in African Americans while controlling for cardiovascular disease, chronic kidney disease, arthritis, education level (ie. Some high school, high school graduate, some college or higher), diet, poverty-income-ratio, PIR, diabetes, gender, and age. The socio-ecological model included in this cross-sectional study …

Clinical Prediction For Surgical Versus Nonsurgical Interventions In Patients With Vertebral Osteomyelitis And Discitis, Jennifer Lee, Miguel A. Ruiz-Cardozo, Rujvee P. Patel, Saad Javeed, Raj Swaroop Lavadi, Catherine Newsom-Stewart, Anton Alyakin, Camilo A. Molina, Nitin Agarwal, Wilson Z. Ray, Michele Santacatterina, Brenton H. Pennicooke

2020-Current year OA Pubs

BACKGROUND: Vertebral osteomyelitis and discitis (VOD), an infection of intervertebral discs, often requires spine surgical intervention and timely management to prevent adverse outcomes. Our study aims to develop a machine learning (ML) model to predict the indication for surgical intervention (during the same hospital stay) versus nonsurgical management in patients with VOD.

METHODS: This retrospective study included adult patients (≥18 years) with VOD (ICD-10 diagnosis codes M46.2,3,4,5) treated at a single institution between 01/01/2015 and 12/31/2019. The primary outcome studied was surgery. Candidate predictors were age, sex, race, Elixhauser comorbidity index, first-recorded lab values, first-recorded vital signs, and admit diagnosis. …

Advancing Clinical Microbiology: Applications And Future Of Next-Generation Sequencing, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Next-generation sequencing (NGS) has reformed infectious disease management, including COVID-19. While real-time polymerase chain reaction (PCR) is widely used for rapid pathogen detection, it requires predefined targets. NGS offers an unbiased approach, detecting multiple pathogens simultaneously without prior knowledge. Despite its potential, NGS implementation in clinical settings faces challenges like high costs and technical complexity. NGS platforms like Illumina, Ion Torrent, and Nanopore provide high-throughput sequencing, identifying pathogens and resistance markers. Applications include whole genome sequencing (WGS), metagenomic NGS (mNGS), and targeted NGS (tNGS). Integrating NGS with conventional methods could improve diagnostics, but current evidence is mixed for supporting its …

Immune Responses To Mycobacterium Tuberculosis Infection In The Liver Of Diabetic Mice, Ali Badaoui, Kayvan Sasaninia, Aishvaryaa Shree Mohan, Abrianna Beever, Nala Kachour, Anmol Raien, Afsal Kolloli, Ranjeet Kumar, Santhamani Ramasamy, Selvakumar Subbian, Vishwanath Venketaraman

Student Publications

Individuals with uncontrolled diabetes are highly susceptible to tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) infection. Novel treatments for TB are needed to address the increased antibiotic resistance and hepatoxicity. Previous studies showed that the administration of liposomal glutathione (L-GSH) can mitigate oxidative stress, bolster a granulomatous response, and diminish the M. tb burden in the lungs of M. tb-infected mice. Nonetheless, the impact of combining L-GSH with conventional TB treatment (RIF) on the cytokine levels and granuloma formation in the livers of diabetic mice remains unexplored. In this study, we evaluated hepatic cytokine profiles, GSH, and tissue pathologies …

Advanced Hiv Disease And Associated Factors Among Young People Aged 15-24 Years At A Tertiary Hospital In Sierra Leone: A Cross-Sectional Study, Mamadu Baldeh, Samuel Kizito, Sulaiman Lakoh, Daniel Sesay, Samuel Adeyemi Williams, Umu Barrie, Frida Dennis, Dimbintsoa Rakotomalala Robinson, Franck Lamontagne, Franck Amahowe, Patrick Turay, Ozge Sensoy Bahar, Elvin Geng, Fred M Ssewamala

2020-Current year OA Pubs

BACKGROUND: Advanced HIV disease (AHD) in young people living with HIV (PLHIV) is an increasingly pressing public health issue in sub-Saharan Africa. Despite global progress in early HIV testing and reducing HIV-related deaths, many youths experience increased rates of HIV disease progression in sub-Saharan Africa. This study describes the burden, clinical manifestations, and factors for disease progression among young PLHIV aged 15 - 24 years seeking medical services at a major public hospital in Sierra Leone.

METHODS: We performed a cross-sectional analysis of routinely collected data for PLHIV patients aged 15 to 24 seen at Connaught Hospital in Sierra Leone …

Changes In Plasma Concentrations Of Per- And Polyfluoroalkyl Substances After Bariatric Surgery In Adolescents From The Teen-Longitudinal Assessment Of Bariatric Surgery (Teen-Labs) Study, Brittney O Baumert, Sandrah P Eckel, Jesse A Goodrich, Zhenjiang Li, Nikos Stratakis, Douglas I Walker, Yinqi Zhao, Fabian Christoph Fischer, Scott Bartell, Damaskini Valvi, Xiangping Lin, Zoe Coates Fuentes, Thomas Inge, Justin Ryder, Todd Jenkins, Rohit Kohli, Stephanie Sisley, Stavra Xanthakos, Sarah Rock, Michele A La Merrill, Rob Mcconnell, David V Conti, Lida Chatzi

Faculty, Staff and Students Publications

Exposure to per- and poly-fluoroalkyl substances (PFAS) is ubiquitous due to their persistence in the environment and in humans. Extreme weight loss has been shown to influence concentrations of circulating persistent organic pollutants (POPs). Using data from the multi-center perspective Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort, we investigated changes in plasma-PFAS in adolescents after bariatric surgery. Adolescents (Mean age = 17.1 years, SD = 1.5 years) undergoing bariatric surgery were enrolled in the Teen-LABS study. Plasma-PFAS were measured at the time of surgery and then 6-, 12-, and 36 months post-surgery. Linear mixed effect models were used to evaluate …

Around The Center, 1998 August/September, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on art therapy.

Around The Center, 1997 June, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the Creticos Cancer Center.

Around The Center, 1997 November/December, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the affiliation with Norwegian-American Hospital.

Around The Center, 1996 March, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on patient satisfaction surveys.

Challenges And Opportunities In Cancer Immunotherapy: A Society For Immunotherapy Of Cancer (Sitc) Strategic Vision, Leisha A Emens, Pedro J Romero, Ana Carrizosa Anderson, Tullia C Bruno, Christian M Capitini, Deborah Collyar, James L Gulley, Patrick Hwu, Avery D Posey, Ann W Silk, Jennifer A Wargo

Faculty, Staff and Student Publications

Cancer immunotherapy has flourished over the last 10-15 years, transforming the practice of oncology and providing long-term clinical benefit to some patients. During this time, three distinct classes of immune checkpoint inhibitors, chimeric antigen receptor-T cell therapies specific for two targets, and two distinct classes of bispecific T cell engagers, a vaccine, and an oncolytic virus have joined cytokines as a standard of cancer care. At the same time, scientific progress has delivered vast amounts of new knowledge. For example, advances in technologies such as single-cell sequencing and spatial transcriptomics have provided deep insights into the immunobiology of the tumor …

Examining The Cues To Action Of Christian Parents And/Or Guardians Who Are Hesitant To Vaccinate Pediatric Populations, Marcia S. Jackson

Doctoral Dissertations and Projects

As a result of skepticism related to vaccine administration, many newborns and children are without their standardized and recommended vaccinations due to parent and/or guardian beliefs. It is the parent and/or guardian who holds the power to vaccinate their children. Vaccine administration is one of the most successful achievements of public health intervention in the 20th century. The purpose of this study is to use a descriptive case study analysis approach to assess parents' and/or guardians' concerns, attitudes, beliefs, and intentions towards immunizations for their children (from birth to 18 years of age). Understanding the "why" and "how" concerns raised …

Lived Experiences, Perceptions, And Caregiving Trajectories Of Family Caregivers Of Youth With Substance Use Disorders (Suds) In Zambia, Ireen Manase Kabembo

Lingnan Theses (MPhil & PhD)

There is unequivocal evidence that family caregivers contribute to healthcare systems worldwide by providing care for persons with chronic illnesses in the home setting. his study explores the lived experiences, perceptions, and caregiving trajectories of 30 family caregivers of youth aged 16-24 diagnosed with Substance Use Disorders (SUDs) in Zambia. Data was collected through in-depth semi-structured interviews, a caregiving timeline, and participant observation and analysed using interpretative phenomenological analysis. Guided by the integrated theoretical framework of positioning theory and the theory of caregiving dynamics, this study offers a new lens for understanding caregiver’s experiences regarding caregiver identity, self-perceptions, interpersonal relationships, …

Synthetic Assembly Of Antibacterial Agents And Metal Chelating Ligands, Zachary Joseph Liveris

Dissertations

The exploitation of chemical synthesis exemplifies the notion of bridging both innovation and curiosity for the strategic assembly of sophisticated molecular infrastructures. By exerting this continuously evolving and versatile tool, synthesis has been applied in the development and influence of a myriad of ligands, biological probes, and persists to direct pharmaceutical innovation and modern medicine alike. Since pathogenic multidrug-resistant (MDR) microbial strains remain to be a persistent threat to both clinical healthcare and society, the need to develop selective and efficacious antibacterial agents that can impede microbe pathogenicity and regulate cellular mortality is paramount. In contrast to pharmaceutical development, organic …