Digital Commons Network^™

Early Host Defense Against Virus Infections, Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen

Presidential Fellows Articles and Research

Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease. The field of immunology has been shaped by broad concepts, including the pattern recognition theory that currently dominates innate immunology. Focusing on early host responses to virus infections, we analyze the literature to build a working hypothesis for the principles that govern the early line of cellular antiviral defense. Aiming to ultimately arrive at a criteria-based theory with strong explanatory power, we propose that both controlling infection and limiting inflammation are key drivers for the early cellular antiviral …

Improving Immunization Rates In Children Under Two Years Of Age In Linn County, Kansas Through Nursing Education, Heather L. Webber

Doctor of Nursing Practice Scholarly Project

Immunizations are one of the most beneficial preventive health measures available to children under two years of age. Failing to receive these preventative immunizations during these crucial years could result in the child developing serious diseases that may lead to long term disability or even be fatal. By increasing immunization rates, children will be more protected against common childhood diseases which will allow them to grow and thrive. The purpose of this scholarly project was to identify ways to improve vaccination rates in children under two years of age at specific clinics in Linn County, Kansas, using healthcare professional education. …

The Efficacy And Safety Of Nirsevimab In The Prevention Of Rsv Related Infections In Healthy Infants, Gabrielle Mayo, Suyin Ballard

Physician Assistant Capstones, 2020-current

Objective: To assess the efficacy and safety of preventing Respiratory Syncytial virus (RSV) related respiratory illnesses and hospitalization with the use of Nirsevimab, as compared to placebo among infants among healthy early and late preterm infants less than one year of age. Design: Systematic Literature Review

Methods: Searches were done using Pubmed and the search term Nirsevimab in Fall 2023. Records were excluded from analysis if full text was not available, studies other than randomized control trials or if included infants that were not healthy or born before 29 weeks gestation. Results: Of the 3 studies, 2 studies demonstrated reduction …

Discrete Particle Dynamics Models: Computational Aspects And Applications, Yuxuan Wu

Doctoral Dissertations and Master's Theses

Particle dynamics considers discrete particles as Newtonian point masses in diverse domains such as, pedestrian particles in pedestrian movement modeling and molecules in material science modeling. These dynamic modeling approaches share a commonality in computational approach where a series of ordinary differential equations are solved for the particle’s motion and equilibrium under active interactions and boundary conditions. In general, particle dynamics approaches are computationally intensive and address problems that require a vast parameter design space. In this dissertation, a computational paradigm is developed for large-scale particle dynamics modeling and demonstrated by three process design applications, (a) infection risk modeling for …

Practicing Responses To Acute Clinical Troubles: Initiative Through Clinical Education (P.R.A.C.T.I.C.E.) To Improve Medical Emergency Response Increasing Nurse Confidence And Preparedness Through Low-Stakes Clinical Education, Lauren Castelblanco Rn, Viviana Lopez Rn, Nosa Odiase Rn, Everly Pompa Rn

Master's Projects and Capstones

A newly established pediatric outpatient infusion center in Los Angeles does not have immediate access to a Code Blue Team or a Rapid Response Team, and instead relies on the Staff Assist protocol to manage medical emergencies. Via direct interviews, registered nurses at the infusion center report feeling underprepared and lacking confidence to respond to medical emergencies that must be escalated to code blue. Microsystem assessment tools determined the root cause to be limited clinical exposure and limited opportunities for skills development. To address the nurses' concerns, Practicing Responses to Acute Clinical Troubles: Initiative through Clinical Education (P.R.A.C.T.I.C.E.) was implemented …

The Rise Of Artificial Intelligence In Pharmacy: Transforming Medication Management And Patient Care, Gracia Anastasya, Miski A. Khairinisa

Pharmacology and Clinical Pharmacy Research

Artificial intelligence (AI) is rapidly transforming healthcare, with significant implications for pharmacy practice. This review explores the diverse applications of AI in pharmacy, emphasizing its potential to revolutionize medication management, patient care, public health, disease management, and pharmacy workflow efficiency. AI algorithms can analyze a vast amount of patient data, allowing pharmacists to identify potential drug interactions, evaluate medication safety and effectiveness, and offer personalized treatment suggestions. In the realm of public health, AI supports disease management through epidemiological monitoring and targeted interventions. Additionally, AI-driven robotic dispensing systems and automated inventory management enhance pharmacy workflow efficiency by streamlining operations and …

A Kid's Guide To Infectious Disease, Abby Carroll

Honors Theses

A Kid’s Guide to Infectious Disease is an educational illustrated book intended for young pediatric patients, ages three to five. This project was inspired by my personal interests, involvement at the University of Mississippi, and experience as a medical assistant. Over the past couple of years, I have had the opportunity to work as a medical assistant, interacting with many pediatric patients and their families at HealthPointe Primary Care. As a pre-physician assistant student studying biology, I was inspired to create a resource for these kids by both my classes at the University of Mississippi and my passion for pediatric …

The Evidence Is In: Breast Implants Are Making People Sick Increasingly Women Find When They Have Their Implants Removed, Their Symptoms Improve—Or Disappear., Pamela J. Appea

Capstones

Over the years, breast implants have been associated with a wide range of health issues, including cancer and autoimmune diseases, but surprisingly these issues are not well known to the public. In 1992, health concerns led the FDA to halt the use of silicone gel breast implants for cosmetic surgeries, although implants containing saline remained available (it was during this period that the Oprah segment that Gmitro remembered ran on TV). In 2006, after more research, which some experts believe was insufficient, the FDA re-approved the use of silicone implants. In 2019, a novel “textured” breast implant manufactured …

Baby-Friendly Hospital Initiative: Becoming Baby-Friendly Designated, Krystal Angelique Mora

Master's Projects and Capstones

Section I: Abstract

Problem Despite efforts to increase breastfeeding rates, the influence of formula companies has contributed to the decrease in rates, affecting the health outcomes of infants. In response, the Baby-Friendly Hospital Initiative (BFHI) introduced standardized education for nursing staff to support infant growth and development. Context Hospital A Birth Center is a 33-bed culturally diverse unit that provides care to mothers in Northern California, delivering approximately 7,400 babies each year and helping patients transition into motherhood. Aim The quality improvement project aims to enhance the retention of BFHI-aligned education provided during hospitalization by 26.2%, raising retention rates among …

Cardiac Effects And Comorbidities Of Neurological Diseases, Bi̇lgi̇n Öztürk

Turkish Journal of Medical Sciences

Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, and peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These disorders profoundly impact cardiovascular health, prompting an intensified exploration into the intricate interconnections between the neurological and cardiovascular systems. This review synthesizes current insights and research on cardiovascular comorbidities associated with major neurological conditions, including stroke, epilepsy, Parkinson’s disease, multiple sclerosis (MS), and Alzheimer’s disease.The cardiovascular sequelae of these neurological disorders are multifactorial. For instance, strokes not only predispose individuals to arrhythmia and heart failure but also exacerbate pre-existing …

Infant Mortality Data: Missing Pieces To Prevention In Lesotho, Jacinda Croissant

Master's Projects and Capstones

Lower-middle-income countries (LMICs) like Lesotho lack complete and quality infant mortality data. Without infant mortality data, it can be challenging to develop public health education, programming, and policies to address preventative infant deaths in specific populations (Rao et al., 2004). A literature review identified strategies to improve infant mortality data in LMICs. Through a community engagement model and digital storytelling, community members can gain awareness, begin an ongoing conversation about local public health issues, and participate in an improved data collection system. Infant mortality is often used as an indicator of health for a population; improved infant mortality data can …

A Home Is A Human Right: Homelessness In Sacramento, Alexa Renée Colvin

Master's Projects and Capstones

Homelessness is a public health crisis in California and needs to be addressed. Homelessness directly impacts health outcomes through increased barriers of care and unmet needs. It affects people in all walks of life, but the risk of experiencing homelessness increases within marginalized communities. The solution to end homelessness is not straightforward, and requires collaboration across federal, state, and local organizations. A literature review was conducted to understand what the homelessness crisis looks like broadly in California, and more specifically in Sacramento, and create informed recommendations. This literature found that implementing a structured and collaborative housing first approach is a …

Baby-Friendly Hospital Initiative: Becoming Baby-Friendly Designated, Joann Chu Zheng

Master's Projects and Capstones

Problem Global breastfeeding rates remain low despite numerous breastfeeding benefits, which poses significant challenges and contributes to adverse infant health outcomes. In response, the Baby-Friendly Hospital Initiative (BFHI) was established to advocate, defend, and uphold breastfeeding encouraging healthy infant development from birth through early childhood. Context Hospital A is in the East Bay with a perinatal unit seeking BFHI certification. A microsystem assessment identified the need to ensure that postpartum nurses deliver accurate and consistent BFHI-aligned education to meet designation requirements. Intervention A standardized patient checklist conforming to baby-appropriate education guidelines was developed to improve the quality and thoroughness of …

Engineering Functionalized Nanomaterials For Targeting And Ablating Biofilms On Surfaces, Dhanush Lakmal Yapa Amarasekara

Theses and Dissertations

Biofilms on both the surface and interior of medical devices pose major challenges, including hindering device performance and serving as infection sources. These biofilms form a protective layer around bacteria, shielding them from the body’s immune system and antibiotics. This makes infections difficult to treat, as the bacteria within the biofilm are resistant to both antibiotics and immune defenses. Additionally, biofilms can induce inflammation and irritation in nearby tissues, leading to further health complications. Antibiotic resistance raises concerns about the emergence of multi-drug resistant (MDR) pathogens. MDR infections are difficult to treat, leading to prolonged hospital stays and the need …

Fisheries Management In Mississippi State-Operated Fishing Lakes: A Review And Look To The Future, Hayden Gregory Funk

Theses and Dissertations

The Mississippi Department of Wildlife, Fisheries and Parks currently manages 18 State Lakes and 17 State Park Lakes to provide public fishing opportunities. My goal was to conduct a comprehensive analysis of monitoring and management activities in State Lakes to enhance understanding of lake dynamics, further develop existing management initiatives, and identify alternative avenues for effective management. To achieve this objective, I have undertaken a comprehensive examination and synthesis of the historical background pertaining to State Lakes and conducted an analysis of pertinent data regarding lake characteristics such as the physical and chemical attributes of the lakes, the features of …

Evaluation Of Current Management Strategies For The Tarnished Plant Bug And Tobacco Thrips In Midsouthern Cotton, Hunter Lane Lipsey

Theses and Dissertations

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is an important economic pest of cotton, Gossypium hirsutum (L.), in the Midsouth region of the United States. An experiment was conducted to determine the impact of insecticide class loss on yield and Lygus populations in the recently commercialized ThryvOn cotton technology. Data indicated no significant yield loss when excluding any currently utilized insecticide class for tarnished plant bug management. An additional objective was to reevaluate the sampling interval necessary to scout ThryvOn cotton for Lygus. No significant differences were observed between a 3 or 7-day sample interval compared to plots …

Description And Influence Of Diseases On The East Mississippi Catfish Industry, And The Role Of Clay Minerals, Iron, And Aluminum Salts In The Susceptibility Of Channel Catfish To Aeromonas Hydrophila And Edwardsiella Ictaluri, Mark Alan Peterman

Theses and Dissertations

In 2014, a virulent clonal group of Aeromonas hydrophila (VAH) was the predominant disease impacting the east Mississippi (EMS) commercial catfish industry. The EMS aquatic ambulatory service observed an area not prone to VAH outbreaks. In addition, frequent underestimations of the scope and economic impact of the EMS catfish industry and its diseases warranted a descriptive effort. Therefore, the EMS catfish industry, its economic impact, the diseases of this region and their economic impact were described. Further, differences in water and geological chemistry of the area not prone to VAH outbreaks, and the sensitivity of VAH and Edwardsiella ictaluri to …

Anemia And Adherence To Weekly Iron-Folic Acid Supplementation Among Adolescent Girls In A Stunting Locus Of Ambon City, Indonesia, Yudhie D. Tando, Christiana R. Titaley, Ritha Tahitu, Elpira Asmin, Liyani S. Sara

Journal of Health Research

Background: Anemia remains a major public health concern among adolescent girls in Indonesia. To address this, weekly iron-folic acid (IFA) supplementation has been implemented nationwide. This study examined factors associated with anemia and adherence to IFA supplementation among adolescent girls in three senior high schools within the Poka-Rumah Tiga Health Centers' catchment area in Ambon City, Indonesia.

Methods: A cross-sectional survey was conducted in August 2022 involving 522 female students from three senior high schools in Ambon City. Factors associated with anemia and adherence to weekly IFA supplementation were examined using logistic regression.

Results: A high prevalence of anemia (49.23%) …

​​Living With Parkinson’S During Covid-19: A Survey Of Parkinson’S Patients During Covid-19​, Sia Shaila Pilgaonkar

Undergraduate Theses

The COVID-19 pandemic has significantly impacted individuals with Parkinson's disease (PD), raising concerns about exacerbation of symptoms and vulnerability of the patients. This project first reviews existing literature on the interconnections between COVID-19 and PD, focusing on the physiological, psychological, and treatment-related challenges faced by patients. Then it analyzes survey data examining increased severity of COVID-19 in individuals with PD, alongside the literature researching potential mechanisms linking the two, such as inflammation and neurodegeneration. The survey’s key areas of focus included symptom management, treatment satisfaction, the impact of PD on daily living, and the impact of COVID-19 on motor and …

Elevated Ambient Temperature Associated With Reduced Infectious Disease Test Positivity Rates: Retrospective Observational Analysis Of Statewide Covid-19 Testing And Weather Across California Counties., Nicholas Wing-Ping Kwok, Joshua Pevnick, Keith Feldman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: From medication usage to the time of day, a number of external factors are known to alter human body temperature (BT), even in the absence of underlying pathology. In select cases, clinical guidance already suggests the consideration of clinical and demographic factors when interpreting BT, such as a decreased threshold for fever as age increases. Recent work has indicated factors impacting BT extend to environmental conditions including ambient temperature. However, the effect sizes of these relationships are often small, and it remains unclear if such relationships result in a meaningful impact on real-world health care practices.

OBJECTIVE: Temperature remains …

Why Law "Beyond The State" Need Not Be A Threat To Democratic Values, Paul Schiff Berman

Buffalo Law Review

Discussions of “law beyond the state” almost inevitably run into objections from those who believe that sub- or supranational legal orders necessarily subvert local democratic governance. Self-proclaimed populists and others express concern that the “will of the people” will be unduly subjected to the dictates of “cosmopolitan elites”1 or local factions, or corporate capture. These objections range across the political spectrum. Those on the right tend to focus on concerns that transnational orders will impose human rights or immigration rules on a national polity, while those on the left worry about trade regimes that might impose local labor or environmental …

Safety, Immunogenicity, And Efficacy Of A Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever With Thrombocytopenia Syndrome Virus And Heartland Bandavirus, Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates

Animal, Dairy, and Veterinary Science Faculty Publications

Background: Severe fever with thrombocytopenia syndrome virus (STSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases. With a high case fatality ratio, SFTSV has been designated a high priority pathogen by the WHO and the NIAID. Despite this, there are currently no approved therapies or vaccines to treat or prevent SFTS. Vesicular stomatitis virus (VSV) represents an FDA-approved vaccine platform that has been considered for numerous viruses due to its low sero-prevalence in humans, ease in genetic manipulation, and promiscuity in incorporating foreign glycoproteins into its virions. Methods: In this study, we developed a …

Systemic Antibiotic Selection In Skin And Soft Tissue Infections, Shafira Anindya Purnawan, Windy Keumala Budianti, Sandra Widaty

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Antibiotics are used in daily practice. To properly select antibiotics, it is important to pay attention to the definitive diagnosis, class of antibiotic, dose, interval, route of administration, and exact duration of use.

Discussion: The World Health Organization (WHO) categorizes antibiotics into three groups: Access, Watch, and Reserve—known as the AWaRe classification—to help guide appropriate usage and combat antibiotic resistance. The Gyssens flowchart serves as a valuable tool for clinicians to qualitatively evaluate antibiotic utilization. In skin and soft tissue infections (SSTIs), treatment strategies are tailored according to the characteristics of the infection, including purulence, necrosis, and overall severity. …

Design, Synthesis, And Nmr-Guided Characterization Of A Targeted Covalent Inhibitor-Like Molecule Against Ivyp1 From P. Aeruginosa, Samuel Taylor Moore

Master's Theses

Multi-drug resistance poses a serious threat to future generations and historical antibiotic pipelines; consequently, the medical and economic burdens associated with treating multidrug-resistant bacteria are substantiated. In this context, P. aeruginosa (PA) emerges as one of the most significant healthcare challenges, being a leading cause of resistance-associated mortality worldwide. Despite modern efforts to combat these poor outcomes, drug-resistant cases continue to rise, and the need for novel antibiotic treatment is apparent. To this end, we investigated relevant resistance mechanisms and past antibiotic targets within PA, and in doing so, we identified relationships between peptidoglycan biology and a periplasmic protein, Inhibitor …

Volume 41-1 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 41-1 Complete Issue

Drinking Water Issues And Management In The Republic Of The Philippines, William James Smith, Jr

The Geographical Bulletin

Major drinking water issues and management schemes in the Republic of the Philippines are examined utilizing a political geographic perspective. By examining these issues and management schemes, administrators in developing countries, such as the Philippines, can provide more effective drinking water management for their citizens. Effective drinking water management is an essential building block in the foundation of sustainable development. This type of socio-political and economic research demonstrates the importance of equity in "safe" drinking water distribution, and the value of watershedbased and integrated natural resource management. The importance of recognizing the provision of safe drinking water as a human …

Serological Study Of Prevalence Toxoplasmosis In Different Animals In Basra Province, Iraq, Sarah Kamal Naser

Al-Ameed Journal for Medical Research and Health Sciences

The current study is designed to identify Toxoplasma gondii at animals in Basra province - Iraq, (109) blood samples in all were collected from cows, sheep, goats and cats in urban domestic and Al-zubair abattoir (sheep n=42, goats n=19, cows n=24, and cats n=24) at Basra province were tested using a serological test to the identification of anti-Toxoplasmosis antibodies in animals during beginning of October 2022 until the end of April 2023, this research demonstrated that the overall infection rate was (19%), the highest rate observed in cats (33%), followed by sheep and goats (21%), the findings of the present …

Staphylococcus Epidermidis St2 Strains Associated With Bloodstream Infections Contain A Unique Mobile Genetic Element Encoding A Plasmin Inhibitor, Amy A Gomez, Clara Kjerfve, Minseo Choi, Wen Liu, Kelly Churion, Sheila Thomas, Holger Rohde, Sam Shelburne, Jon T Skare, Magnus Hook, Srishtee Arora

Faculty, Staff and Student Publications

Staphylococcus epidermidis, a common commensal bacterium, is a leading cause of nosocomial catheter-associated bloodstream infections. S. epidermidis sequence type 2 (ST2) is specifically recognized globally for causing invasive disease. In this study, we identified a novel putative integrated conjugative element, pICE-Sepi-ST2, unique to the genomes of S. epidermidis ST2. Our investigation identified pICE-Sepi-ST2 in all ST2 isolates from bloodstream infections. Meanwhile, ST2 isolates from other infection sources, such as catheters, prosthetic joints, and fracture fixations, showed variable pICE-Sepi-ST2 prevalence. pICE-Sepi-ST2 encodes two putative cell wall anchored proteins that we have designated SesX and SesY. Biochemical characterization of SesY revealed …

Nomenclature For Human And Animal Fungal Pathogens And Diseases: A Proposal For Standardized Terminology, Sybren De Hoog, Thomas J Walsh, Sarah A Ahmed, Ana Alastruey-Izquierdo, Maiken Cavling Arendrup, Andrew Borman, Sharon Chen, Anuradha Chowdhary, Robert C Colgrove, Oliver A Cornely, David W Denning, Philippe J Dufresne, Laura Filkins, Jean-Pierre Gangneux, Josepa Gené, Andreas H Groll, Jaques Guillot, Gerhard Haase, Catriona Halliday, David L Hawksworth, Roderick Hay, Martin Hoenigl, Vit Hubka, Tomasz Jagielski, Hazal Kandemir, Sarah E Kidd, Julianne V Kus, June Kwon-Chung, Shawn R Lockhart, Jacques F Meis, Leonel Mendoza, Wieland Meyer, M Hong Nguyen, Yinggai Song, Tania C Sorrell, J Benjamin Stielow, Rachel Vilela, Roxana G Vitale, Nancy L Wengenack, P Lewis White, Luis Ostrosky-Zeichner, Sean X Zhang

Faculty, Staff and Student Publications

Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal pathogens complete their life cycle in environmental habitats or occur as commensals within or on the vertebrate body, but under certain conditions can thrive upon infecting humans. The extent of host damage in opportunistic infections largely depends on the portal and modality of entry as well as on the host's immune and metabolic status. Diseases caused by primary pathogens and common opportunists, causing the top approximately …

Wildlife Factors And Zoonotic Spillover In Sub-Saharan Africa, Bernard Mgba

Doctoral Dissertations and Projects

Zoonotic spillover, the transmission of infectious pathogens from animals to humans, is a critical public health concern in Sub-Saharan Africa. This study examines the role of wildlife factors in zoonotic spillover within this region, highlighting the complex interplay between human-wildlife interactions, environmental changes, and emerging zoonotic diseases. The research underscores that Sub-Saharan Africa is particularly vulnerable due to its rich biodiversity, cultural practices involving wildlife, and socioeconomic challenges. Factors such as habitat encroachment, wildlife consumption, and inadequate health infrastructure contribute to the heightened risk of zoonotic spillover. The study employs an online survey followed with a contextual analysis, and socioeconomic …