Digital Commons Network^™

From Lab To Clinic: A Toolbox To Address Concerns Regarding Vaccine Safety, Elijah Thalos, Alexandra Yonts, Isabela Gomes

URGENT Matters

No abstract provided.

Coinfections In Infectious Keratitis: A Case Involving Herpes Simplex Virus (Hsv) Type 1 Infection, Saeed S Alqahtani

Internet Journal of Allied Health Sciences and Practice

Purpose: Infectious keratitis remains a major cause of corneal morbidity and vision loss. While bacterial keratitis is commonly encountered, coexisting viral infections may complicate diagnosis and delay effective treatment. This case report highlights the importance of recognizing polymicrobial keratitis in patients with atypical or non-resolving clinical courses. Method: We describe the clinical course, diagnostic evaluation, and management of a 40-year-old female contact lens wearer who presented with a severe corneal ulcer initially presumed to be bacterial in origin. The patient was treated with intensive fortified topical antibiotics based on clinical suspicion of Pseudomonas aeruginosa infection related to prolonged contact …

Quantile Normalisation Enables Interpretable Spatial Prioritisation Of Persistence-Related Mechanistic Suitability Under Uncertainty For Tomato Red Spider Mite (Tetranychus Evansi) In Africa, Komi Mensah Agboka, Luca Rossini, Quinto Juma Meltus, Bonoukpoè Mawuko Sokame, Abdulmutallab G.A. Azrag, Thomas Dubois, Elfatih M. Abdel-Rahman

All Peer-Reviewed Publications

Mechanistic trait models are increasingly considered to estimate persistence-related suitability for invasive species, although translating reproduction metrics into operational indicators for spatial decision-making remains challenging. Branching-process transformations are widely applied to convert mechanistic reproduction numbers into probabilities of establishment; however, such transformations may compress spatial gradients when persistence is broadly feasible. Using tomato red spider mite (Tetranychus evansi) as a case study across Africa, this study developed an uncertainty-aware, physiologically-based model and generated spatially explicit estimates of expected reproduction (R0). We compared three representations: raw mechanistic suitability, branching-process persistence probability, and quantile-normalised suitability. Although all representations preserved rank ordering, branching …

Single Immunoglobulin Interleukin1-Related Receptor-Twist1 Axis Regulates Barrier Function In Neonatal Intestine., Aparna Venkatraman, Wei Yu, Heather Menden, Sherry M. Mabry, Joshua Wheatley, Shahid Umar, Susana Chavez-Bueno, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND & AIMS: The genetic basis of impaired intestinal barrier function in preterm infants is poorly understood. Variants in single immunoglobulin interleukin1-related receptor, a negative regulator of Toll-like receptor signaling, have been identified in preterm infants with necrotizing enterocolitis. We hypothesized that single immunoglobulin interleukin1-related receptor variants associated with necrotizing enterocolitis impair gut barrier function to pathobionts. The aim of this study was to determine how single immunoglobulin interleukin1-related receptor genetic variants disrupt neonatal intestinal barrier integrity and promote susceptibility to Gram-negative bacteria implicated in sepsis and necrotizing enterocolitis pathogenesis.

METHODS: Transgenic mice and preterm infant-derived enteroids expressing SIGIRR variants …

Posaconazole Target Attainment In Critically Ill Children: A 15-Year Single-Center Retrospective Analysis., Kathryn Pavia, Addison M. Pritchett Ms, Jennifer Goldman

Manuscripts, Articles, Book Chapters and Other Papers

Posaconazole is a triazole antifungal agent used for prophylaxis and treatment of invasive fungal diseases. Posaconazole has high inter-individual variability in dose-exposure relationship and benefits from therapeutic drug monitoring (TDM). Adult studies report particularly high rates of subtherapeutic exposure among intensive care unit (ICU) patients related to changes in physiology during critical illness. The rates of subtherapeutic posaconazole exposure among critically ill children in ICU's are unknown. This single-center retrospective analysis at a large freestanding children's hospital used TDM results from 2010 to 2025 obtained while patients were undergoing care in a pediatric ICU. Therapeutic targets were ≥ 1.0 mg/L …

Phar 571.00: Integrated Studies V, Kendra A. Proacci, Andrew J. Eberling

University of Montana Course Syllabi, 2026-2030

No abstract provided.

2026 Report On The State Of Great Salt Lake Social Science, Creed Jones, Avyrlie Smith, Shae Barber, Stacia Ryder, Mufti Nadimul Quamar Ahmed, Georgie Corkery, Jennifer Givens, Anna Mcentire, Carla Trentelman, Jessica Ulrich-Schad, Kirsten Vinyeta, Bryn Watkins

Publications

Great Salt Lake (GSL) faces rapid decline that presents more than just a hydrological risk; it poses an existential social hazard. As water levels decline, ecosystems, economies, cultures, and societies face irreversible harm. Since the lake reached its lowest levels in 2022, this issue has specifically gained increased attention in Utah and beyond. Given both the degree to which human consumption contributes to the problem, and the potential risks that the drying of the lake poses for community health, social science research is a crucial for informing successful water management policies and mitigating impacts. The purpose of this report is …

Alzheimer’S Disease And Related Dementias Risk Profiles And Health Literacy Among South Asian Seniors, Sandra A. Kennedy

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease and Related Dementias (ADRD) pose significant health challenges globally, with South Asian seniors in the United States facing elevated risks due to high rates of cardiovascular disease, diabetes, and limited health literacy. This study assessed dementia literacy and the prevalence of cardiovascular, psychosocial, and lifestyle risk factors among South Asian seniors in New York City, utilizing community-based participatory research (CBPR) principles in collaboration with India Home, a community-based organization. Fifty-six (N=56) South Asian seniors aged 55 and older (M = 69.05, SD = 6.36), primarily of Indian or Bangladeshi origin, participated in the study. Data collection involved a …

The Ramifications Of Covid-19 On Young Adults With Ocd, Clare E. Mcintosh

Dissertations

The coronavirus disease of 2019 (COVID-19) pandemic was a profound event in modern history, contributing to significant disruptions on a societal and individual level. This period of time was marked by elevated uncertainty and fear among individuals. COVID-19 contributed to deterioration in not only physical health but also psychological well-being. One mental health condition frequently under-examined and saturated with misconceptions is obsessive-compulsive disorder. Obsessive-compulsive disorder is a condition characterized by the presence of obsessions and/or compulsions. Intolerance of uncertainty is a core component of the condition, and the pandemic was riddled with unpredictability. The purpose of this study was to …

Fluorescence-Based Methods For The Determination Of Selected Β-Lactam Antibiotics (Amoxicillin, Cefixime, And Cephalexin): A Review, Kardos Musheer Khorsheed, Tara Fuad Tahir, Ahmad F. Hama Sdiq

Polytechnic Journal

β-Lactam antibiotics constitute one of the most extensively prescribed classes of antimicrobial agents in human and veterinary medicine. However, their widespread use has raised growing concerns regarding antibiotic resistance, drug safety, and the presence of residual antibiotics in pharmaceutical products, biological fluids, foodstuffs, and environmental samples. As a result, the development of sensitive, selective, and rapid analytical methods for the determination of β-lactam antibiotics has become critically important. Among the available analytical techniques, fluorescence-based methods have gained increasing attention due to their high sensitivity, operational simplicity, low cost, and suitability for trace-level detection. This review presents a comprehensive overview of …

Emergency Contraception, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Prediction Model For Children With Anaphylaxis Who May Not Require Emergency Department Care: A Multicenter Retrospective Cohort Study., Timothy E. Dribin, David Schnadower, Hugh A. Sampson, Yin Zhang, Nanhua Zhang, Stephen B. Freedman, Mark I. Neuman, David C. Brousseau, Rakesh D. Mistry, Stephanie Boyd, Yonatan Wolnerman, Patrick S. Walsh, Craig Vander Wyst, Vandana Thapar, Jonathan Strutt, Geetanjali Srivastava, Nidhi V. Singh, Christopher J. Russo, Christian D. Pulcini, Thuy L. Ngo, Jo-Ann O. Nesiama, Matthew M. Moake, Ashley M. Metcalf, Tamar R. Lubell, Juhee Lee, Chari D. Larsen, Karen Y. Kwan, Curtis L. Knoles, Kajal Khanna, Julia F. Freeman, Justin R. Davis, Alicia Daggett, Joanna S. Cohen, Ari R. Cohen, Wee-Jhong Chua, Sri S. Chinta, Brittany Boswell, Kelly R. Bergmann, Paul L. Aronson, Kenneth A. Michelson

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The 2023 US Anaphylaxis Practice Parameter indicated that some patients receiving epinephrine in the community might avoid emergency department (ED) visits; however, the criteria and safety of this approach remain unproven.

OBJECTIVE: To derive and validate a clinical prediction model for identifying children at risk of receiving epinephrine after arriving at the ED.

METHODS: We conducted a 31-center retrospective cohort study of children aged 6 months to less than 18 years who received 1 prehospital dose of epinephrine for allergic reactions between 2016 and 2019. The outcome was receipt of epinephrine after ED arrival. We used least absolute shrinkage …

Endocarditis Caused By Candida (Candidozyma) Auris, Farah Ebrahim, Mzee Ngunga, Abdulaziz Abeid, Hilda Nasibwa, Newnex Mongare, Rodney Adam

Internal Medicine, East Africa

Candida (Candidozyma) auris has emerged as a hospital-acquired pathogen and was first reported in East Asia in 2009. Infective endocarditis due to C. auris has been rarely reported, while other Candida species account for < 2% of infective endocarditis (IE) cases. Herein we report three cases of endocarditis caused by C. auris , including a native aortic valve, a native tricuspid valve, and a prosthetic valve. Each of these cases had been in healthcare settings months to years earlier that were the likely sources of their infec- tions. These cases suggest the possibility for indolent but life-threatening infections from C. auris . ©2026 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Trends In Antimicrobial Resistance Associated With Gastrointestinal Tract Infections In The Uae: A Comprehensive Retrospective Surveillance 13-Year (2010-2022) Study, Madikay Senghore, Jens Thomsen, Najiba M. Abdulrazzaq, Wei Chen, Eveline Kaambo, Stefan Weber, Fouzia Jabeen, Godfred Antony Menezes, Abiola Senok, Dean B. Everett, Carole Ayoub Moubareck

All Works

Background This study analyzes longitudinal trends in AMR among key bacterial pathogens causing GI infections across the United Arab Emirates (UAE), to inform future treatment policies and public health interventions. Methods We conducted a 13-year, nationwide, longitudinal surveillance study (2010-2022) using data from 341 public and private healthcare facilities and 45 diagnostic laboratories across the UAE. Pathogen identification and antimicrobial susceptibility testing followed WHO GLASS standards, supplemented by WHONET-integrated electronic medical records. Statistical analyses assessed trends in pathogen incidence, resistance patterns, geographic distribution, and associations with clinical outcomes. Findings Out of 15,593 laboratory-confirmed GI cases, the highest burden was observed …

Vomica And Respiratory Distress: A Complicated Lung Hydatid Cyst In A Child., Riccardo Guanà, Antonella Peduto, Maria Grazia Sacco Casamassima, Marco Denina, Marco Petraz, Cristina Giuliano, Giuseppe Farruggio, Lucia Gerbaudo, Fabrizio Gennari

Manuscripts, Articles, Book Chapters and Other Papers

Hydatid cyst, caused by Echinococcus infection, is the most common parasitic lung infection in children. Giant cysts are generally the result of a late diagnosis and are associated with a high risk of spontaneous rupture and life-threatening complications, including anaphylactic shock. We present the complex management of a large, complicated hydatid cyst of the lung in an 11-year-old boy in a nonendemic area. This case highlighted the specific work-up and surgical treatment of lung cysts as well as the differential diagnosis to consider when treating pulmonary masses or pneumonia.

The Role Of External Factors In Shaping Carbohydrate Conformational Landscapes, Murat Yaman

Dissertations, Theses, and Capstone Projects

Carbohydrates (glycans) are among the most structurally diverse biomolecules and participate in a wide range of biological processes, including molecular recognition, cell adhesion, immune response, host-pathogen interactions, and cellular signaling. Their biological functions are governed by a complex interplay between sequence, stereochemistry, conformational flexibility, and environmental factors. However, the structural heterogeneity and dynamic nature of glycans present significant challenges for both experimental characterization and theoretical modeling. In particular, the relationships between glycan structure, conformational dynamics, and the resulting potential energy surfaces remain incomplete.

This dissertation investigates how external factors modulate the potential energy surfaces of carbohydrates through a combination of …

Pacific Rxtracts - September 2026, Pacific Rxtracts

Pacific RxTracts

Articles

• Efficacy of Daraxonrasib Versus Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (Breaking News)
• A Multi-Drug, All-Age Unified PopPK Model for Aminoglycoside Dosing (General News)
• Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence (Cardiology)
• Low-Dose Hydrocortisone and Cognition in Women With HIV (Endocrine)
• Rethinking Pediatric Propofol Limits in the Absence of PRIS (Pediatrics)
• Eptinezumab in Chronic Migraine and Medication Overuse Headache: The RESOLUTION Trial (Neuropsychology)
• Ropeginterferon alfa-2b-njft Treatment in Essential Thrombocythemia: Mutation-Stratified Outcomes from EXCEED-ET (Oncology)
• Respiratory Syncytial Virus Vaccine Effectiveness in Medicare Beneficiaries Residing in Nursing Homes (Infectious Disease)
• Conclusive Evidence in Support of Amoxicillin …

Nurses' And Families' Experiences Of A Feasibility Trial Comparing Single‐Use And Multiple‐Use Endotracheal Suction Catheters In Mechanically Ventilated Patients: A Qualitative Study, Mohamed H. Eid, Kevin Hambridge, Patricia Schofield, Jos M. Latour

School of Nursing and Midwifery

BackgroundIn resource-limited Intensive Care Units (ICUs), reusing endotracheal suctioning catheters is often standard practice due to supply constraints or staffing pressures. Randomised controlled trials (RCTs) have explored the impact of these practices on patient outcomes. However, less is known about the experiences of nurses and family members involved in RCTs testing endotracheal suctioning interventions.AimTo explore the experiences of ICU nurses and family members participating in a feasibility RCT comparing single-use versus multiple-use endotracheal suction catheters flushed with chlorhexidine or normal saline in a resource-limited ICU setting.Study DesignA qualitative study was embedded within a feasibility RCT. Semi-structured interviews were conducted with …

Antimicrobial Stewardship: Aspiration Pneumonia And Anaerobic Antibiotic Coverage, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

A National Study Of Tetanus Vaccine Knowledge, Receipt And Acceptance Among Emergency Department Patients, Francesco Sergi, Elisa Vaezazizi, Shaokui Ge, Christopher Alvarez, Jesus Torres, Brian Chinnock, Michael Gottlieb, Vijaya Arun Kumar, Kristin L. Rising, Efrat Kean, Stephanie Eucker, Robert M. Rodriguez

Department of Emergency Medicine Faculty Papers

OBJECTIVE: The Tetanus, Diphtheria, Pertussis (Tdap, "tetanus") vaccine is recommended for adults every 10 years. In a national sample of adult emergency department (ED) patients, we sought to determine (1) knowledge and up-to-date status of the tetanus vaccine; (2) reasons for nonreceipt of the vaccine; (3) vaccine acceptability if offered in the ED; and (4) reasons for nonacceptance in the ED if offered.

METHODS: This was a cross-sectional survey study among non-critically ill adults at 10 US EDs, asking questions about knowledge, receipt, and acceptability of the tetanus vaccine. Vaccine receipt was determined by self-report. Aggregate responses are reported as …

Molecular Detection Of Staphylococcus Aureus: A Performance Comparison Of Colony Pcr And Conventional Pcr Targeting The Icab Gene, Farah Badri Abed, Shahrazad Hazim Muhi, Sahar Mustafa Ibrahim, Riyam Alaa Mohammed

Muthanna Medical Journal

Background: Staphylococcus aureus is an important nursing disease that requires a prompt and effective diagnosis to implement a strategy to curb its transmission and spread. Although the gold standard is the conventional PCR using column-purified genomic DNA, Colony PCR with crude cell lysates saves a lot of time and cost of the test and its performance features have not been well established.
Objectives: This paper will compare Colony PCR (boiling method) and Conventional PCR (ABIOpuretm kit extraction) to amplify icaB gene (141 bp), which is a major determinant of biofilm formation in S. aureus and then assess their application with …

Irs: Iterative Reference Selection Improves Normalization Of Microbiome Sequencing Data, Yiming Shi, Lili Liu, Jun Chen, Kristine M Wylie, Todd N Wylie, Sung Hee Park, Ruiwen Zhou, Yin Cao, Stephanie A Fritz, Molly J Stout, Maria Cristina Vazquez Guillamet, Lei Liu

2020-Current year OA Pubs

Microbiome studies often seek to determine how the absolute abundances of individual taxa change across biological conditions, yet sequencing read counts are sample-specific scaled representations of those abundances. Because sampling depth can differ across samples, fold changes calculated directly from sequencing read counts do not generally represent absolute-abundance fold changes. Normalization methods attempt to account for these between-sample differences in sampling depth, but their accuracy depends on the reference used. In particular, total-sum scaling uses all taxa as the reference and can introduce compositional bias. Reference-based methods instead rely on taxa that are stable across conditions, but contamination of the …

Responding To Medetomidine In Philadelphia: Narrative Summary Of The Public Health Response To A New Psychoactive Substance, Tareva Warrick-Stone, Serge-Emile Simpson, Phil Durney, Dennis Goodstein, Catherine Abrams, Raymond Bobb, Kory London, Daniel Teixeira Da Silva

Division of Internal Medicine Faculty Papers & Presentations

BACKGROUND: Despite the emergence of medetomidine as the dominant adulterant in Philadelphia's illicit opioid supply, coordinated public health responses are limited or non-existent in the literature. Thus, we summarize a recent Summit in Philadelphia of outpatient and inpatient service providers who specialize in the care of persons who use drugs to discuss medetomidine response readiness and building ongoing community readiness for potential destabilizing drug supply changes.

PURPOSE: Describe a public health intervention that distributed information about practices across health care settings and mobilized key informants to identify and address barriers to treatment.

METHODS: Descriptive summary of the in-person Summit organized …

Spatial Association Of Acute Respiratory Infection, Diarrhea, And Low Birth Weight With Stunting Prevalence In Indonesia, 2024, Dian Rosadi, Husaini Husaini, Triawanti Triawanti, Musafaah Musafaah

Kesmas

Stunting remains unevenly distributed across Indonesia, but national evidence integrating spatial analysis and spatial regression is limited. This study examined the spatial distribution of stunting and its associations with acute respiratory infection (ARI), diarrhea, and low birth weight (LBW) across Indonesian provinces. An ecological cross-sectional study used data from the 2024 Indonesian Nutritional Status Survey. Stunting-only analyses included all 38 provinces, whereas analyses involving ARI, diarrhea, and LBW included 37 provinces with complete data. Spatial analyses used a row-standardized symmetric four-nearest-neighbor spatial weights matrix and included Global Moran’s I, bivariate spatial analysis, Local Indicators of Spatial Association, ordinary least squares, …

Data Curation And Integration For Cancer Cell Line Pharmacogenomics Analysis, Meric Kinali

Graduate Masters Theses

Cancer cell lines are essential resources for connecting genomic and molecular features with drug response and identifying biomarkers. Therefore, large-scale cancer cell line resources have been growing, but this introduces challenges such as data standardization, consistent annotation, matching identifiers, cross-database integration, and a reproducible computational framework. CellMiner Cross Database (CellMinerCDB) integrates pharmacogenomic datasets from multiple resources and provides a standardized analysis of cell lines across datasets. This thesis examines cancer cell line cross-databases and their importance in pharmacogenomics, with a particular focus on CellMinerCDB. As part of this work, I developed an R package for the gCSI (Genentech Cell Line …

Evaluation Of Antibiotic Use Using The Gyssens Method On Clinical Outcomes In Ischemic Stroke Patients, Juniarto Mende, Graciano A. Maturbongs, Yohana K. A. Mbulang

Pharmacology and Clinical Pharmacy Research

Ischemic stroke is a health problem that causes death and neurovascular disability worldwide. The inflammatory response due to infection can increase ischemic stroke and increase brain damage through changes in blood pressure, coagulation, immune response, and endothelial function. This study aims to evaluate the rationality of antibiotic use on clinical outcomes in ischemic stroke patients. This study used a cross-sectional design. Retrospective data were taken from the medical records of Jayapura Regional Hospital for the period January 1, 2023, to May 31, 2025. The study subjects were all patients who suffered ischemic stroke and received antibiotics. Evaluation of the rationality …

Tracking Toward Zero: Implementing A Picc Team Tracker To Prevent Clabsis, Christian Justin Carreon

Master's Projects and Capstones

Problem: Central line-associated bloodstream infections (CLABSIs) remain a significant and preventable patient safety concern in acute care settings, contributing to increased morbidity, mortality, prolonged hospitalization, and substantial healthcare costs.

Context: At Hospital A, a tertiary referral center in Northern California, six adult CLABSIs were identified between June and December 2025 following an eight-month CLABSI-free period. Four events occurred in adult medical surgical telemetry. All peripherally inserted central catheter (PICC) line CLABSIs were attributed to gaps in maintenance bundle adherence and the lack of a standardized, real-time tracking mechanism for the PICC Team.

Interventions: A PICC Team Tracker was implemented as …

Shaping Disease: Colonial Stigma And The Politics Of Health In Banyuwangi, The Early Twentieth Century, Rifa'i Shodiq Fathoni, Skriptyan Noor Hidayatullah Syuhri, Vini’Matu Hikmah, Ardhita Zahra Namira

Paradigma: Jurnal Kajian Budaya

This article examines the colonial stigma attached to Banyuwangi as an “unhealthy region” in the early 20th century, a label used to justify massive exploitation of its natural resources. Using a historical method, this research analyzes how this stigma not only served as a tool for colonial legitimation but also causatively created conditions that triggered ecological disasters and a public health crisis in a previously isolated area. Through an analysis of primary sources such as colonial reports, health journals, and newspapers, this article traces how large-scale plantation exploitation, enabled by the stigma, led to deforestation, uncontrolled labor migration, and poor …

Dynamics Of Swimming Microorganisms At Structured Liquid Crystal Interfaces, Vajra Sabhapathy Badha

Graduate Doctoral Dissertations

Active matter systems are self-driven units that consume energy to generate motion and mechanical stresses, producing non-equilibrium states of broad physical significance. Examples include synthetic microswimmers and migrating cells. Motile bacteria are a widely studied biological example because their self-propelled motion, hydrodynamic interactions, and collective organization are strongly coupled to local environmental conditions. Their swimming is sensitive to interfacial viscoelasticity, ordering, confinement, and hydrodynamic boundary effects, making them useful for investigating how interfaces regulate active biological motion. Because bacterial accumulation and attachment at interfaces are central to colonization and biofilm formation, these interactions are relevant to both active matter physics …

Strengthening Vaccine Confidence Among College Freshmen In The Post-Covid-19 Era, Karlen E. Luthy, Janelle L. B. Macintosh, Alyssa Vang, Janessa Johnson

International Nursing Research Congress (INRC)

The purpose of this study was to examine the effect of a vaccine education module (VEM) on college freshmen’s intended vaccination behaviors, vaccine-related perceptions, and vaccine knowledge. Although vaccine requirements for university students are a vital public health strategy, most institutions in the United States do not mandate all recommended immunizations. In today’s environment, where vaccine misinformation and hesitancy remain common, understanding how evidence-based education influences vaccine attitudes is increasingly important. A pre-COVID-19 study showed that a VEM improved students’ vaccine beliefs and intentions; this study assessed these outcomes in a post-COVID-19 context.

A pretest/posttest quasi-experimental design was used. Participants …