Digital Commons Network^™

Prevalence Of Coronavirus And Rotavirus In Dairy Calves In North-Central Of Algeria, Dadda Anes, Mohamed Cherif Abdellah, Khelef Djamel

The Thai Journal of Veterinary Medicine

Coronavirus and Rotavirus have been reported as the two main pathogens implicated in neonatal gastroenteritis in calves. The aim of this study is to provide descriptive and analytical epidemiological data and to evaluate the influence of infection with these two viruses on the onset of diarrhea in calves less than 60 days old. In our study, we included 35 dairy cattle farms in the north-central part of Algeria from January 2019 to December 2021. We analyzed 152 samples using the Copro-ELISA test, which revealed a prevalence of 10.53% and 9.87% for Rotavirus and Coronavirus, respectively. The analysis of the results …

Effects Of Deliberate Practice On Psychomotor Skill Retention In Nursing Students, Annette Oberhaus

School of Nursing Faculty Publications

Psychomotor skills are considered a foundational block for nursing education, yet the approach to teaching these skills varies from program to program.

The goal of this quality improvement project is evaluation of the effects of a systematic change in the method of instructing nursing students in psychomotor skills. The hypothesis is that the use of Deliberate Practice for instruction will promote long-term skill proficiency and retention.

Emergency Vehicle Dispatching Model Considering Demand Urgency And Delivery Fairness, Long Kejun, Liu Jia, Gao Zhibo, Chen Suqian, Zhang Zhonggen

Journal of China & Foreign Highway

In emergency vehicle dispatching after unexpected events，it is crucial to prioritize critical nodes with high demand urgency while minimizing excessive delivery delays at other nodes to prevent secondary impacts.On this basis，this study developed an emergency vehicle dispatching model that considered demand urgency and delivery delay fairness.Firstly，the entropy weight-TOPSIS method was used to calculate the demand urgency for each node，and a delivery delay balance index was introduced to minimize disparities in delivery delays between nodes.Secondly，a multi-objective optimization model was established with total delivery time，overall cost，and delivery delay balance as objectives，while considering constraints such as inventory levels at distribution centers and route …

Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier

Online Theses and Dissertations

Urbanization has led to major forest loss and negatively impacts ecosystem services. Urban reforestation efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity across a 20-year chronosequence of RTB sites. Acoustic detectors were deployed across 10 different-aged plantings at 60 randomly-defined detector locations. Each planting was surveyed across 8 sampling periods from May – August 2023. Each recording session spanned ca. 7 consecutive nights, yielding a total of …

Barry Conservation Camp Health Form, Andy Schafermeyer

UNH Cooperative Extension

No abstract provided.

Clover (Clostridium Difficile Vaccine Efficacy Trial) Study: A Phase 3, Randomized Trial Investigating The Efficacy And Safety Of A Detoxified Toxin A/B Vaccine In Adults 50 Years And Older At Increased Risk Of Clostridioides Difficile Infection, Curtis J Donskey, Erik R Dubberke, Et Al.

2020-Current year OA Pubs

BACKGROUND: Clostridioides difficile infection (CDI) causes substantial mortality and healthcare burden. We assessed the detoxified toxin-A/B PF-06425090 vaccine for primary CDI prevention.

METHODS: This phase 3 observer-blinded study randomized (1:1) ≥50-year-olds at increased CDI risk (N = 17 535) to receive 3 PF-06425090 or placebo doses (0, 1, and 6 months). Primary end points were first CDI episode (≥3 unformed stools within 24 hours; central laboratory-confirmed toxin A/B positive) ≥14 days post-dose 3 (PD3; first primary) and post-dose 2 (PD2; second primary). CDI duration, need for CDI-related medical attention (secondary end points), and antibiotic use (post hoc analysis) PD3 were …

Corynebacterium Minutissimum As A Rare Cause Of Tibial Osteomyelitis: A Case Report And Literature Review, Ayub Ansari, Dania Shoaib, Maher Asfour, Xiyue Wang, Pooja Sharma

Student Publications

Osteomyelitis is commonly caused by pathogens like Staphylococcus aureus, but rare organisms such as Corynebacterium minutissimum, typically associated with superficial skin infections, can also be implicated. Recognizing these atypical pathogens presents diagnostic and therapeutic challenges, especially in the presence of orthopedic hardware. We conducted a literature review yielding 25 studies and encompassing 797 patient cases, which highlights the emerging role of Corynebacterium species in osteomyelitis, particularly following trauma or surgical interventions. A 72-year-old man with a history of chronic right tibia and fibula fractures from a motor vehicle accident presented with progressively worsening leg pain over six months. …

Gene-Environment Interactions In Non-Alcoholic Fatty Liver Disease: Insights From Mexican American Populations, Eron G. Manusov, Vincent P. Diego, Marcio Almeida, Jacob Galan, Auwal A. Bala, Marco Arriaga, Natasha Garcia-Rodriguez, Renee Hernandez, Satish Kumar, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Nonalcoholic Fatty Liver Disease (NAFLD) is a prevalent and complex condition influenced by both genetic and environmental factors. This chapter explores the genotype-by-environment interactions that contribute to the development and progression of NAFLD in the Mexican American population. Using advanced genetic epidemiology and bioinformatics approaches, we investigated how specific genetic variants interact with environmental factors such as depression, acculturation stress, and social determinants of health, to influence NAFLD risk and severity. Our findings reveal significant genotype-by-environment interactions for key NAFLD-related traits, including HbA1c, AST/ALT ratio, and steatosis-controlled attenuation parameter (CAP). We also discuss the application of cutting-edge proteomic and transcriptomic …

Skin Lesions, Weight Loss, And Facial Swelling After A Hand Injury, Yuriko Fukuta, Cindy Qinyang Wu, Todd Michael Lasco, Abdul Hafeez Diwan

Faculty, Staff and Students Publications

No abstract provided.

Pleural Empyema: Etiology And Pathogenesis, Daniel M Musher, Sherwood Gorbach, Joshua Fierer

Faculty, Staff and Students Publications

No abstract provided.

Comparing Multivalent Cross-Linked Sodium Alginate/ Montmorillonite Beads Containing Curcumin Or Cayenne Pepper As Drug Carriers And Their Antimicrobial Resistance, Shionainn Traynor, Shubham Sharma

SURE Journal: Science Undergraduate Research Experience Journal

The aim of the following work was to investigate and compare curcumin and cayenne pepper in microbeads composed of sodium alginate (SA) crosslinked with montmorillonite (MMT) to act as drug carriers and their antimicrobial resistance. The microbeads were prepared through ion-exchange in multivalent solutions of CaCl₂, MgCl₂ and AlCl₃. The microbeads were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and the time required for intercalation of curcumin and cayenne pepper with MMT. Simulated intestinal fluid (pH 7.3) and gastric fluid (pH 1.2) at 37°C were used for comparison in swelling studies. …

Mathematical Modelling Of Disease Outbreak, Favour Christian, Matthew Molloy

SURE Journal: Science Undergraduate Research Experience Journal

Establishing a model framework for more research necessitates a thorough understanding of the causes, distribution, prevalence, and evolution of infectious illnesses. The main mathematical concept used in this modelling simulation is ordinary differential equations (ODEs). The purpose of this study was to investigate the significance of the many criteria linked to a zombie virus spread. The zombie framework provides an accessible and relatively simple representation of the nature of infectious disease spread, allowing for tractable assumptions and the development of more complex situations.

The models are designed around a zombie outbreak in which the zombie virus is spread through a …

Editorial - Sure Journal Vol 6, Anne M. Friel, Eva Campion, Sinead Loughran

SURE Journal: Science Undergraduate Research Experience Journal

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Identification Of Conserved Eukaryotic Gene Products In Novel Mycobacteriophage, Brandon Mar, Jade Coxon, Lily Esterline, Sydney Clifford, Gabriella Burke, Mallory Motz, Alaina Gartner, Kioni Bush, James Lin, Lizzie Adams, Sophia Palant

The Journal of Purdue Undergraduate Research

Bacteriophage, a type of virus that infects bacteria, was discovered 100 years ago, initially isolated with a plaque assay in the 1940s. A mycobacteriophage is a subtype of bacteriophage that specifically infects mycobacteria. Since the introduction of DNA technologies and efforts to identify a plethora of bacteriophages, over 10,000 bacteriophages have been identified with 1,500 sequenced. Bacteriophage discovery has aided in genetic editing techniques, the development of synthetic biology tools, and disease treatment. However, to be able to expand on these capabilities, there is a need to identify more bacteriophages and sequence the genomes of these viruses, as they outnumber …

Next Generation Sequencing Based Profiling Of Genes In Patients With Syndromic Forms Of Retinitis Pigmentosa, Harshavardhini G

Theses and Dissertations

India is one of the largest populations in the world and is estimated to have a high prevalence of Retinitis Pigmentosa (RP). RP is clinically and genetically heterogenous, characterized initially as night blindness, leading to complete vision loss due to retinal degeneration. RP can occur in non-syndromic or syndromic forms, affecting other organs as observed in Bardet Biedl Syndrome (BBS) and Usher syndrome (USH).

BBS is characterized by RP, polydactyly, obesity, renal anomalies and learning difficulties. USH is characterized by RP and sensorineural hearing loss (SNHL), with variable presence of vestibular dysfunction. Nextgeneration sequencing (NGS) has become a cost-effective technology …

Evaluating Pulmonary Tuberculosis Knowledge Deficits Among Nursing Students In The United States, Jamie Lynn Woo

Nursing | Student Research Posters

The healthcare field consistently faces patients with a wide range of diseases and illnesses. Pulmonary Tuberculosis is an infectious lung disease with established tools to prevent, detect, and treat it. Yet, there has been a significant rise in cases within the past year. Amidst this troubling situation, it is crucial that all healthcare workers, nursing students, and nurses in particular, are properly educated on caring for TB patients. This research proposal aims to determine if there are TB treatment knowledge gaps among nursing students in the United States by conducting a 20-question survey utilizing the Likert Scale. If results show …

Effectiveness Of An Improved Leprosy Lakar Training On Knowledge And Skills Among Healthcare Workers In Primary Healthcare In Pahang Malaysia., Nuraihan Zafirah Zainal Abidin

Student Works (2020-2029)

Leprosy, a neglected chronic tropical disease caused by Mycobacterium leprae, poses significant health challenges due to its potential for irreversible disabilities and disfigurement. Adequate leprosy training for healthcare workers (HCWs) is crucial for early detection and prompt treatment, thereby preventing complications and reducing transmission risks. This study aimed to revise and evaluate the effectiveness of leprosy LaKAR* training on knowledge and skills of leprosy among HCWs in primary healthcare in Pahang, Malaysia. The study employed a sequential exploratory, mixed-method design consisting of two phases. Phase 1a was a qualitative study identifying gaps in current LaKAR training among HCWs at …

Feasibility Of A Low-Intensity Intervention To Influence Antibiotic Prescribing Rates Use In Outpatient Settings: A Cluster Randomized Controlled Clinical Trial, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

Background. Primary care providers (PCPs) may modify their antibiotic prescription practices if aware of their potentially damaging impact. Methods. We conducted a cluster randomized controlled trial at 12 Veterans Affairs community-based outpatient clinics. PCPs at clinics randomized to the intervention group received quarterly antibiotic use reports with feedback about antibiotics prescribed for acute respiratory infections and adverse event letters alerting about Clostridioides difficile infection or antibiotic-resistant gram-negative bacteria among their patients. The main outcome, antibiotic prescriptions in primary care visits, was compared in the preintervention (April–September 2020), intervention (October 2020 to September 2021), and postintervention periods (September 2021 to September …

Cutaneous Nodules Secondary To Mycobacterium Avium Complex In A Patient With Human Immunodeficiency Virus, Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen

Faculty, Staff and Students Publications

We present a patient with human immunodeficiency virus who developed multiple painful lesions that previously in the past had speciated as Cryptococcus neoformans cutaneously, and in the lung. Despite induction therapy for presumed re-infection, the patient did not improve so a biopsy was performed and this was speciated as Mycobacterium avium complex, with final diagnosis being disseminated Mycobacterium avium complex. This case highlights the importance of considering a broad differential diagnosis for any new lesions regardless of prior culture data.

Whispers In The Wind: Face Mask Sampling For Mycobacterium Tuberculosis Detection In Children With Pulmonary Tuberculosis, Lennard Meiwes, Irina Kontsevaya, Dumitru Chesov, Stela Kulciţkaia, Viola Dreyer, Doris Hillemann, Qiniso Dlamini, Caroline Williams, Michael Barer, Folke Brinkmann, Renate Krüger, Stephanie Thee, Alexander Kay, Anna Maria Mandalakas, Christoph Lange

Faculty, Staff and Students Publications

Background: Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA in children and performed a clinical exploration to assess feasibility in children.

Methods: Face masks were spiked, analyzed on GeneXpert-Ultra, quantitative polymerase chain reaction, and targeted next-generation sequencing. Children with pulmonary tuberculosis were asked to wear 3 modified FFP2 masks for 30 minutes as part of an exploratory clinical study.

Results: Experiments with H37Ra M. …

Intouch Week Of December 16, 2024, New York Medical College

InTouch

• New Skyline Auditorium Opens with Ribbon-Cutting Ceremony
• NYMC Secures $200,000 Grant from NYS Division of Criminal Justice
• Medical Students Shape the Future of Medicine Through Research Excellence
• Illuminating Discovery Symposium Showcases Cutting-Edge Innovations in Biomedical Imaging
• Heart and Mind: Studies Unravel Link Between Cardiovascular Disease and Dementia
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Correlation Of Genogroup I, Genotype 1 (Gi.1) Norovirus Neutralizing Antibody Levels With Gi.1 Histo-Blood Group Antigen-Blocking Antibody Levels, Robert L Atmar, Khalil Ettayebi, Frederick H Neill, Ralph P Braun, James Sherwood, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

Background: The in vitro cultivation of human noroviruses allows a comparison of antibody levels measured in neutralization and histo-blood group antigen (HBGA)-blocking assays.

Methods: Serum samples collected during the evaluation of an investigational norovirus vaccine (HIL-214 [formerly TAK-214]) were assayed for neutralizing antibody levels against the vaccine's prototype Norwalk virus/genogroup I, genotype 1 (GI.1) (P1) virus strain. Results were compared with those previously determined using HBGA-blocking assays.

Results: Neutralizing antibody seroresponses were observed in 83% of 24 vaccinated adults, and antibody levels were highly correlated (r = 0.81; P < .001) with those measured by HBGA blocking.

Conclusions: Genogroup I, genotype 1 (GI.1)-specific HBGA-blocking antibodies are a surrogate …

The Burden Mothers Bear: Using The Health Belief Model To Understand How U.S. Mothers’ Intersectional Identities Shape Health Decision-Making During Covid-19, Sydney O'Shay, Kaitlin E. Phillips, Marissa J. Sáez

Publications

The disproportionate impact of COVID-19 on people of color and the burden placed on mothers created a need to better understand how mothers of color made health decisions for their families and communicated these decisions with others during the pandemic. This study investigated how this populations’ intersectional identities played a role in their health decision-making processes and overall experiences during COVID-19. Using the health belief model as a sensitizing concept, we conducted qualitative in-depth interviews with mothers of color across the United States about their lived experiences during the pandemic. Our findings suggest a need for health communicators to address …

Tnf Prevents Establishment Of Anti-Tumor Immunity And Elucidates Toxicities Following Myxoma Virus Based Oncolytic Virotherapy, Miriam Beatriz Valenzuela Cardenas

Biomedical Sciences ETDs

Tumor Necrosis Factor Alpha (TNF) can lead to tumor regression through its direct cytolytic activity, yet it has also been implicated to facilitate tumor progression. This scenario complicates the efficacy and applicability of TNF based therapeutics as treatment for malignancies. In the context of oncolytic virotherapy (OV) which uses replicating viruses to treat tumors and acts by triggering production of pro-inflammatory cytokines, exploring such mechanisms is vital. Here we show that a Myxoma based oncolytic virus (vPD1/IL12) can induce large amounts TNF. The presence of TNF in the context of vPD1/IL12 plays a detrimental role both for tumor regression by …

Testing Vivo-Morpholino Mediated Gene Knockdown Of Stat6, Spi1b, And Hnf4Α In Adult Threespine Stickleback, Stella Dipippo

Honors Scholar Theses

The fibrotic immune response to the cestode parasite, Schistocephalus solidus, varies among threespine stickleback populations. Fibrosis suppresses parasite growth but has costly effects on the fish. Previous genomic studies in stickleback have suggested potential roles of Spi1b, STAT6, and HNF4α in modulating fibrosis severity, but there is presently no evidence for this in-vivo. We used antisense vivo-morpholino oligonucleotides (MOs) to attempt to knockdown the expression of each gene in the liver, spleen, and intestine of adult stickleback. Vivo-MOs have been proven effective in other species of teleost fish, as well as in mice and humans, but …

In Silico-Predicted Cytokeratin Fragment 21-1 (Cyfra 21-1) Immunogenic Epitopes For The Early Detection Of Nasopharyngeal Carcinoma, Brian Umbu Rezi Depamede, Bachti Alisjahbana, Sulaiman Ngongu Depamede, Sanny Hafidhoh, Siti Nururrohmah, Ilham Ngongu Tryawan, Muhammad Yusuf

Chimica et Natura Acta

Nasopharyngeal Carcinoma, an aggressive cancer in the head and neck region is mostly diagnosed at an advanced stage and thus has a poor prognosis. Cytokeratin Fragment 21-1 (CYFRA 21-1) is one of the oncomarkers discovered in saliva. For developing a diagnostic kit, CYFRA 21-1 antibodies and immunogens are needed. Natural CYFRA 21-1 immunogen is difficult to obtain, so it must be made in-silico using bioinformatics. We aim to predict CYFRA 21-1 immunogenic epitope to produce antibodies polyclonal against CYFRA 21-1, which can be used to develop NPC diagnostics. The immunogenic epitopes were predicted and chosen based on antigenicity, surface accessibility, …

Biomedical Potential Of Natural Products From Selected Tanzanian Flora: A Review, Stephen S. Nyandoro, Joan J.E. Munissi

Tanzania Journal of Science

Natural products have been used for treatment of various diseases for thousands of years and served as sources of drug lead compounds for the improvement of livelihood. This paper presents a review on the biomedical potentials of selected natural products isolated from eight plant species indigenous to Tanzania. The review covers research work published between 2010 and 2023, and identifies 33 natural products with different pharmacological properties from Tanzanian plants. These bioactive natural products are discussed with other similar compounds isolated elsewhere from the same or different plant species to get further insights on the potential application in modern medicine …

Dental Hygiene Programs’ Use Of Oral Health Literacy Techniques For Special Needs Patients And Caregivers, Socorro D. Tejeda Diaz

Dental Hygiene ETDs

This study examined oral health literacy communication techniques in dental hygiene programs across the U.S. for special needs patients and their caregivers. The study surveyed 46 U.S. dental hygiene program directors on communication techniques, degrees offered, and subject areas. Two-sample t-tests compared differences in communication techniques between AAS and BAS and subject areas. Most respondents routinely employed printed materials with 2 or 3 concepts, speak slowly, and simple language. When comparing the variances in communication techniques offered in AAS and BAS, we observed a t-statistic of 2.06 with a corresponding p-value of 0.54. This suggests that the mean communication techniques …

In Vitro Screening Of Potential Inhibitors Against Barmah Forest Virus, Karthika Raj Peringoth

Honors Capstone Projects and Theses

No abstract provided.

Vaccines On The Move And The War On Polio, Laura Muñoz-Blanc, Federico Fabio Frattini

Fondazione Eni Enrico Mattei Working Papers

The rising number of refugees and internally displaced people (IDPs) presents new challenges for vaccine distribution and the spread of diseases. How do forcibly displaced population inflows affect infectious diseases incidence in host communities? Can a policy intervention that vaccinates children during their migration mitigate the impacts? To answer these questions, we examine the Pakistani mass internal displacement from the conflict-affected Federally Administered Tribal Areas in 2008. Using a difference-in-differences approach, we compare new polio cases in districts near and far from the conflict zone before and after 2008. The spatial distribution of districts relative to the historical region of …