Digital Commons Network^™

Comparisons Of Unilateral And Limb Symmetry Indexes Between Fixed Dynamometry Testing Modes, Emily E. Frizzell

Honors College Theses

Hamstring muscles strains are extremely common and can vary in severity. The biarticular structure of the hamstring groups is one reason that they are more susceptible to injuries. The recurrence of these injuries is also common even after they have been through a rehabilitation phase in their recovery. This project aims to compare and associate knee flexion and extension muscle performance characteristics between isometric, isotonic, and isokinetic assessment modes. These different modes of assessment will test analyze muscle performance under varying muscle lengths, movement velocities and biomechanical load modes. The data collected from this testing will be analyzed to see …

The Association Between Mental Health, Fear Of Missing Out, And Sleep Quality Among University Students In The Sichuan Chongqing Region, China: A Cross Sectional Study, Yuncheng Jia

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Sleep quality is a critical determinant of health, with poor sleep linked to adverse physical and mental outcomes. Among university students, excessive screen time, social media engagement, and psychological factors like Fear of Missing Out (FoMO) exacerbate sleep disturbances. Despite growing recognition of FoMO’s role in mental health challenges, its direct relationship with sleep quality remains understudied. This study aim to investigates the associations between mental health, FoMO, and sleep quality among university students in China’s Sichuan-Chongqing region, a population highly immersed in digital culture. And provide insight on how sleep quality is shifting in digital era.Methods: A cross-sectional …

The Impact Of Climate Change On Montanans’ Mental Health, Phoebe Bean

Graduate Student Theses, Dissertations, & Professional Papers

Climate change poses many threats to human health, from vector-borne illnesses and food shortages to injuries and premature deaths related to extreme weather events. Less understood outcomes include the consequences of climate change for mental wellbeing; although the field of psychology examining these effects is growing, gaps in the literature regarding climate-related distress persist, particularly regarding the diverse ways in which people experience climate change-related psychosocial impacts and how they cope with distress. Thus, this study examined the impact of climate change on mental wellbeing through a comprehensive survey that sampled Montana residents across the state (n = 247). Results …

A Bioarchaeological Overview Of The Late Woodland Period Gooden Mound Group, Fulton County, Illinois, Aaron M. Durchholz

Theses and Dissertations

Extensive research in paleopathology has documented adverse effects accompanying a shift in subsistence strategy from largely nomadic, hunting and gathering lifestyles to those of more sedentary, agrarian systems. Comparative assessment of the human skeletal remains of early foragers and later farmers recovered from archaeological sites around the world have consistently demonstrated a decrease in average age at death in the latter.

Across the pre-Columbian North American Midwest, the transitional period between the Late Woodland and Mississippian periods, sometimes referred to as the terminal or Mississippian Acculturated Late Woodland, portended establishment of semi-permanent to permanent hamlets, increasingly reliant upon the adoption …

Effect Of Dietary Flavonoids On Growth In Saccharomyces Cerevisiae, Vivian Rivera

Mahurin Honors College Capstone Experience/Thesis Projects

Plant foods contain a diversity of biologically active compounds called phytochemicals, produced by plant species as secondary metabolites. A phytochemical group known as flavonoids has received much scientific attention in recent times with respect to their antioxidative and anti-inflammatory roles. This investigation examined how quercetin and naringenin, the most common dietary flavonoids, affect growth potential of yeast under optimal and stress conditions (temperature, glucose, and oxidative stress). Using Saccharomyces cerevisiae as a model, a dose dependency effect of quercetin and naringenin was observed under optimal conditions when liquid cultures were treated with three different concentrations (75 μM, 150 μM, and …

Gait Entrainment & Energetics Of Young Adults To Discrete Mediolateral Perturbations, Lindsey D. Lee

Graduate Thesis and Dissertation post-2024

Entrainment is a natural phenomenon that occurs with synchronization to a rhythmic stimulus which can be auditory, visual, or mechanical. An everyday example is walking next to someone and synchronizing your steps. Previous studies have explored entrainment from auditory cues, such as a metronome, and mechanical cues, such as an exoskeleton applying a force at the ankle. These studies have found entrainment is more likely to occur if the stimulation frequency is close to the person’s natural locomotion frequency. Previously we found when discrete mediolateral perturbations were applied on a treadmill, participants increased their speed and retained this increased speed …

An Investigation Of Alkb-Family Dna Repair Enzymes And Their Interaction With Synthetic, Modified Oligonucleotides, Samuel Dean Howarth

Open Access Dissertations

Chapter One will detail the synthesis, purification, and characterization of DNA oligonucleotides containing one of fifteen modified nucleic acid bases. For each modification, relevant background information is provided to highlight its biological significance. This chapter primarily focuses on the development of oligonucleotide stocks for use in future biochemical and cellular assays. Several of these modifications are recognized substrates of AlkB-family enzymes, while others remain uncharacterized as potential substrates.^1-4 The discovery of novel substrates for AlkB-family enzymes can be facilitated through comprehensive in vitro biochemical assays, contingent upon the availability of well-characterized substrate stocks. The methods and findings presented here …

Cellular Level Changes Induced In Cancer Cells Due To Microgravity, Sai Deepika Reddy Yaram

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increase in human activity in space has revealed several kinds of physiological challenges brought on by the absence of Earth's gravitational pull. NASA observed that during spaceflight, astronauts experience a 1-1.5% monthly loss in the mineral density of weight-bearing bones, with rehabilitation efforts on Earth often proving ineffective. This issue extends to muscles, the neuro vestibular system, the cardiovascular system, and vision. Cancer has emerged as a significant cause of mortality among astronauts, with studies up to 2017 showing that 41.3% of natural cause deaths among U.S. astronauts were due to cancer, primarily due to space radiation exposure. Cancer …

Sounds Marks, Deborah Gerhardt, Jon J. Lee

Faculty Articles

A lion roars just before a film rolls. A doughboy giggles. A giant green man laughs a hearty, “Ho, Ho, Ho.” These iconic sounds are all federally registered as trademarks. They identify specific brands and distinguish their products and services from the competition. Human brains treat sounds like these as categorization tools and cognitive shortcuts—ideal trademark symbols. But what about the sounds your favorite toys or electronic devices make? Or those made by a fictional character in the latest block- buster? This Article tackles these issues and others. We push back against the widely-held belief that all unconventional trade-marks—product designs, …

Counterterrorism Uses Of Force: The Laws Of War And Jus Ad Vim, Salomon, Paolo

Santa Clara Journal of International Law

Al Qaeda’s terror attacks against the United States on September 11, 2001, introduced heretofore unseen issues under International Humanitarian Law. After Al-Qaeda’s attacks, the Bush administration began its Global War on Terror by invading Afghanistan in order to find those responsible for the attacks on September 11, 20001. This invasion caused Al-Qaeda to flee into Pakistan’s Tribal Areas in order to evade American forces. The Bush administration began employing drone strikes in Pakistan’s Tribal Areas to degrade Al-Qaeda’s ability to conduct operations against the United States. The Obama administration continued and expanded the use of drone strikes. Amid the use …

The Auricular Surface Of Chimpanzees (Pan Troglodytes) As An Indicator Of Age, Kalila Garrison

All Master's Theses

Great ape skeletal remains are scarce and their use in biological profile estimations has been limited. Skeletal remains analysis provides key demographic information and ecological context to the individual. Chimpanzees (Pan troglodytes) share skeletal morphological characteristics with humans, and this study seeks to understand if two noninvasive methods using the auricular surface of the ilium to age human skeletal remains could be applied to chimpanzees. The sample consisted of n = 8 individual left auricular surfaces from known age groups of both sexes. Firstly, the Buckberry and Chamberlain Method assigns numerical values to five different traits on the auricular …

Future Focused: 2023-24 Report Of The President, Office Of The President, Gonzaga University

Office of the President Publications

Each year, Gonzaga University's Office of the President produces an annual Report of the President. This publication that highlights just a few of the many accomplishments over the previous academic year, and is intended to convey gratitude to our Trustees and Regents, benefactors, and many supporters.

Calcium Permeability Of Rat Trpv1 In A Close State When Expressed In Xenopus Laevis Oocytes, Zinnia Adhikary

Theses and Dissertations

Transient Receptor Potential V1 (TRPV1) is a nonselective cation channel, which is expressed in nociceptors/ pain detecting receptors. Activated by a wide variety of exogenous and endogenous physical and chemical stimuli such as heat, TRPV1 is involved in temperature detection, body temperature regulation, and pain perception. It is generally accepted that TRPV1's conductance to cations, including Ca2+, depends on its conformational change from a closed to an open state following gating. In the current study, I observed that the plasma membrane of Xenopus laevis oocytes, upon exogenous expression of rat TRPV1, exhibited weak permeability to Ca2+, as evidenced by the …

Searching For Novel Mutations That Regulates The Mouse Polycystin-2 (Trpp2) Ion Channel, Akhilraj Rajan Pillai

Theses and Dissertations

Polycystin-2 (PC2) is an ion channel belonging to the polycystin subfamily of the transient receptor potential (TRP) cation channel superfamily. Mutations in PC2 are associated with autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases in humans. Despite extensive studies over the past decades, the role of PC2 in normal and ADPKD kidneys remains largely unknown, and the activation and regulation of this ion channel are elusive. To gain a better understanding of the structure and function of the mouse PC2 channel, this study focused on generating five pore mutations in a gain-of-function (GOF) mutant of …

Empowering Children With Special Needs (Cwsn) In Computer Science: An Interactive Hand Gestures Approach To Number Conversion Teaching, Renjith P.R., Jeeva Jose

Journal of Educational Technology Development and Exchange (JETDE)

It is essential for teachers to effectively address the diverse needs of students within the classroom environment, encompassing variations in IQ, communication skills, problem-solving abilities, and mathematical proficiency. Ensuring the inclusion of CwSN (Children with Special Needs) is imperative to prevent social division in the classroom. While the department offers accommodations such as scribes, interpreters, or extra time for examinations, these measures may not fully address the specific needs of CwSN. This study explores the efficacy of employing hand gestures as a teaching tool for CwSN in computer science, particularly in the realm of number conversions. A machine learning-based tool …

Optimizing Large Language Models And Multimodal Approaches For Biomedical Publication And Satellite Imagery, Youngsun Jang

Electronic Theses and Dissertations

This dissertation comprises two main sections: the first focuses on natural language processing (NLP) for extracting key information from scientific literature using large language models (LLMs), and the second addresses remote sensing for detecting natural disasters, such as floods, from satellite imagery using a multimodal approach. The first section investigates methods to enhance Transformer-based models in classifying and extracting information from biomedical scientific publications. Key contributions include the development of a custom dataset for classification and Question and Answering (Q&A) tasks, fine-tuning Transformer models like the Bidirectional Encoder Representations from Transformers (BERT) and addressing multi-span answer issues with the TAg-based …

Befriending Your Anxiety Through The Polyvagal Lens By Utilizing Embodied Imagery, Cassandra Lacroix

Art Therapy | Master's Theses

Many individuals experience anxiety disorders, which can significantly impact their well-being if not properly addressed. Recognizing the need for effective tools to support people with anxiety, this research aligns the key pillars of self-control and present focus awareness of physiological responses through art to harness emotional regulation. This research uses the lens of the polyvagal theory, and looking at embodied imagery, breathwork, and transitional objects to conceptualize ways to help decrease anxiety and enhance body perception and autonomic awareness will be witnessed in participants. The aim of this study was also to establish a strategy that individuals could turn to …

Human Olfactory Assessment Of Scented Volatile Chemical Product Emissions, Jordan Cross, Brian Magnuson, Zachary Limaye, Rashmika Manipati, Chunxu Huang, Jianghui Liu, Brandon Boor, Nusrat Jung

International High Performance Buildings Conference

No abstract provided.

The Impact Of Hot Rolling, Zn And Sn On The Mechanical And Corrosion Characteristics Of Mg-Zn-Ca Alloys, Halil Eren, Ali Güngör, Erkan Koç, Harun Çuğ

Journal of Metals, Materials and Minerals

In this study, it was aimed to develop a biodegradable metallic plate that is an alternative to bioinert metal plates. The main advantage of using biodegradable materials for implants is that they can be gradually replaced with the patient's own tissue, which reduces the need for additional surgeries to remove the implant after it has served its purpose. Magnesium and its alloys can provide biocompatibility as orthopedic implant materials. Mg-Zn-Ca and Mg-Zn-Ca-Sn alloys were prepared using the gravity die casting method. Zn (1.0 wt% and 2.0 wt%) and Sn (0.0 wt%, 0.5 wt% and 1.0 wt%) ratios were used as …

Molecular Determinants Of Trp Channel Gating, Briar J. Bell

Theses and Dissertations (ETD)

Transient Receptor Potential (TRP) ion channels are a family of proteins that contribute to a myriad of physiological functions. They have been extensively studied since their discovery 35 years ago; however, there are still many questions regarding the mechanisms by which they function. This family of proteins is characterized by a generally shared structure: an intracellular N terminus featuring ankyrin repeats, six transmembrane helices including the pore domain, a re-entrant loop and TRP helix, and an intracellular C terminus with varying structure. Each of these regions has been implicated in the regular function of TRPs, while mutations that alter trafficking …

Emerging Chromatin Regulators In Response To Heavy Metal Exposure, Wesley Saintilnord

Theses and Dissertations--Molecular and Cellular Biochemistry

Environmental exposure to heavy metals poses significant threats to human health as they are associated with various developmental and chronic pathologies such as reproductive defects and cancers. Despite their profound risks, a comprehensive understanding of their disease-causing mechanisms is lacking. Most studies point to reactive oxygen species-induced DNA damage; however, their mutagenic potential is relatively weak suggesting the involvement of alternative mechanisms. One important, yet underexplored mechanism, is their ability to rewire the epigenome via DNA methylation and histone variant incorporation, leading to aberrant gene regulatory networks.

This study investigates the epigenetic mechanisms targeted by two ubiquitous heavy metals with …

A Novel In-Vitro Approach To Investigate The Molecular Interaction Between Inhaled Particles And The Human Pulmonary Surfactant System, Bryan Mayville

Browse all Theses and Dissertations

The deployment of military personnel to austere environments poses significant pulmonary health risks from inhalation of particulates including sand, dust, pollution, and heavy machinery exhaust. When particles are less than 10 µm in diameter, they can penetrate deep within the alveoli and embed within the protective lung surfactant monolayer. Here, absorption of surfactant lipids to the particle surface disrupts the essential monolayer configuration needed to reduce surface tension and prevent atelectasis, thus leading to disease. Currently, there are no in vitro surfactant-producing lung cell models capable of studying the effects of inhaled particles on the human pulmonary surfactant system. A549 …

Dysbiosis In Parkinson's Disease: A Meta-Analysis Of Gut Microbiota And Its Role In Gastrointestinal Dysfunction And Disease Progression, Ayan M. Siddiqui Mr.

Honors Undergraduate Theses

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms, including gastrointestinal (GI) dysfunction. Symptoms such as constipation, bloating, and nausea often show early signs before the onset of motor symptoms. Recent research has suggested an essential role of the human gut microbiome and gut dysbiosis, an imbalance in gut microbiota composition, in the pathogenesis of PD. This thesis aims to assess the potential relationship between gut dysbiosis and PD by conducting a meta-analysis, focusing on differences in gut microbiota between PD patients and healthy controls and evaluating their implications for GI dysfunction and PD progression. The …

Development Of A Novel Mitochondria Biosensor, Randall K. James

Graduate Thesis and Dissertation post-2024

Developing new label-free paradigms for functional assays in biomedical research has the potential to catalyze efforts in drug discovery and improve the understanding of complex disorders. Mitochondria are an essential organelle in nearly every eukaryotic organism that perform vital functions such as ATP production, redox signaling, reactive oxygen species (ROS) homeostasis and regulation of programmed cell death. These activities are regulated by electrophysiological processes that occur in the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM) in response to metabolic demands, making them an important physiological marker for bioenergetic studies. Mitochondria dysfunction is an early pathological biomarker of complex …

Advancing Kidney Xenotransplantation With Anesthesia And Surgery – Bridging Preclinical And Clinical Frontiers Challenges And Prospects, Xiaojian Zhang, Hailian Wang, Qin Xie, Yang Zhang, Yixin Yang, Man Yuan, Yuqi Cui, Si-Yuan Song, Jianzhen Lv, Yi Wang

Children’s Nutrition Research Center Staff Publications

Xenotransplantation is emerging as a vital solution to the critical shortage of organs available for transplantation, significantly propelled by advancements in genetic engineering and the development of sophisticated immunosuppressive treatments. Specifically, the transplantation of kidneys from genetically engineered pigs into human patients has made significant progress, offering a potential clinical solution to the shortage of human kidney supply. Recent trials involving the transplantation of these modified porcine kidneys into deceased human bodies have underscored the practicality of this approach, advancing the field towards potential clinical applications. However, numerous challenges remain, especially in the domains of identifying suitable donor-recipient matches and …

Collaborative Intelligence For Safety-Critical Industries: A Literature Review, Inês F. Ramos, Gabriele Gianini, Maria Chiara Leva, Ernesto Damiani

Articles

While AI-driven automation can increase the performance and safety of systems, humans should not be replaced in safety-critical systems but should be integrated to collaborate and mitigate each other's limitations. The current trend in Industry 5.0 is towards human-centric collaborative paradigms, with an emphasis on collaborative intelligence (CI) or Hybrid Intelligent Systems. In this survey, we search and review recent work that employs AI methods for collaborative intelligence applications, specifically those that focus on safety and safety-critical industries. We aim to contribute to the research landscape and industry by compiling and analyzing a range of scenarios where AI can be …

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

The Pathophysiology Of The Death Of Jesus The Christ, C. Thomas Black

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Centuries-long speculation continues regarding the circumstances surrounding the death of the Savior. Over the past century, the Savior’s tribulations between the Last Supper and his death on the cross have been scrupulously examined from a medical viewpoint. In this article I review many of these studies and, using current medical acumen, propose additional inferences and explanations based on scriptural, medical, and historical accounts. The evidence suggests that at some point between Gethsemane and his last moments on the cross, the Lord’s body was pushed beyond the limit that a normal mortal could endure. The Lord did, however, endure and completed …

Particl Plant Medicine, Tommye Dean

Theses and Dissertations

In an era marked by a growing recognition of mental health as a critical component of overall well-being, unconventional approaches to therapeutic interventions have gained prominence. One such intervention coincides with the importance of setting the intersection of psychedelic therapy and interior design, creating a synergistic environment for emotional healing and self-discovery. This thesis ventures to delve into the uncharted territory where the realms of altered states of consciousness and thoughtful spatial design converge, seeking to discover the profound impact this collaboration may have on the therapeutic and design landscape.

Exploring Serotonin 1b Autoreceptor Mediated Regulation Of Serotonin Transporter In Female Mice, Sanyukta Jalihalkar

Theses and Dissertations

Rationale: Serotonin (5-HT) is a crucial neurotransmitter involved in regulating various physiological processes. Dysregulation of the serotonergic system has been implicated in several neuropsychiatric disorders. Though numerous 5-HT receptors exist, the 5-HT transporter (SERT) is responsible for 5-HT clearance in the brain and periphery. 5-HT_1Bautoreceptors regulate 5-HT release and interact with glycogen synthase kinase-3β (GSK3β), which can modulate SERT function via specific Ser44/48 phosphorylation sites. While these findings suggest a potential interplay between 5-HT_1Band GSK3β-mediated SERT phosphorylation in regulating extracellular 5-HT, the primary causal molecular link remains unknown.

Objectives: To investigate if 5-HT_1B activation by …