Digital Commons Network^™

A Quantitative Analysis Of Empathy Trait As A Moderator Of Leadership Behavior, Barbara N. Rodriguez

Theses and Dissertations

There are indications that empathic concern for others has been declining around the world (Konrath et al., 2014). Empathy has long been recognized as a component of social functioning that significantly influences behavior that impacts relationships with others on both personal and societal levels (Batson, 2009; Davis, 2017; M. L. Hoffman, 2000; Stilwell, 2001). Leaders who apply empathy in their leadership can promote stronger connections with others (Gentry & Sadri, 2007), and foster social closeness and well-being (Morelli et al., 2015). While traits and behaviors are helpful predictors of effective leadership (Judge & Piccolo, 2004; Mumford et al., 2000), there …

Configuring Thermal Ablation Volumes For Treatment Of Distinct Tumor Shapes: A Repeatability Study Using A Robotic Approach, Milica Bulatović, Jan Hermann, Pascale Tinguely, Iwan Paolucci, Stefan Weber

Faculty, Staff and Student Publications

Objectives: In the current clinical practice of thermal ablation treatment for liver tumors, achieving consistent and effective clinical outcomes across tumors of varying shapes, sizes and locations remains challenging. The aim of this study was to evaluate the repeatability of a novel robotic approach for configurable ablation of distinct tumor shapes and compare it to the standard ablation technique for creating ellipsoidal ablation volumes.

Materials and methods: The repeatability was evaluated in terms of width variability in created ablation volumes. Using a robotic navigation platform, custom ablation profiles configured with power, time, and distance parameters were designed to create four …

Determinants Of Physicochemical Composition Of Palm Oil Mill Effluent - Implications On Environment And Bio-Digester Treatment Design, E.B. Tambe, A.U. Okonkwo, I.E. Mbuka-Nwosu, C.O. Cookey, E. Agbe, S.C. Onwusa, I.N. Ekpe, U.F. Evuen, J. Okpoghono

Applied Environmental Research

Growing need for renewable energy and addressing challenges associated with indiscriminate wastes disposal has necessitated harnessing wastes to wealth. The study investigated parameters determining the physicochemical composition of palm oil mill effluent (POME) generated at Agricultural Development Authority Palm (ADAPALM) and palm oil mills in its catchment communities, located at Ohaji/ Egbema Local Government Area of Imo State, Nigeria and their implications on environmental health and treatment approaches required. Survey research design was used. From a randomly sampled small-scaled mill in each community, and for the lone medium and large-scaled mills, four homogenous samples of POME were collected from sampled …

Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang

All ETDs from UAB

This dissertation focuses on developing predictive modeling using data from two areas: clinical data and microbiome data. Compositional data in real life are mainly represented by relative proportions. With the advancement of next-generation sequencing (NGS) technology, researchers can now collect a large volume of metagenomic sequencing data, which is valuable for investigating associations between the microbiome and host diseases. Current methods for dealing with such data are either constrained by generalization or limited by application. In the first part, to address this, we propose Bayesian compositional generalized linear models for analyzing microbiome data (BCGLM). This model incorporates a structured regularized …

Integrating Natural Light For Wellbeing, Performance, And Quality Care Delivery In Healthcare Environments, Ademola Adebayo Akinbami

Other Faculty of Arts, Humanities and Business Theses

The global challenge of addressing human ill-health demands a re-evaluation of the multifaceted factors impacting health outcomes. Rising health issues in society impose significant burdens on healthcare professionals, affecting their comfort, overall well-being, and performance. While issues like inadequate funding and medical equipment shortages are frequently discussed, a growing recognition centres on the pivotal role that architecture and the built environment play in shaping health outcomes. Poorly designed healthcare facilities contribute to staff shortages and poor care outcomes. Consequently, architecture's transformative potential within the built environment becomes essential in advancing human health, well-being, and productivity. Interestingly, the impact of a …

Bridging The Gap: Technological Mediation And The Development Of Humanistic Skills In Medical Simulation: Lessons From Covid-19 And The Impact Of Immersive Media And Minimal Viable Simulation (Mvs), Nicholas Peres

School of Art, Design and Architecture Theses

This thesis provides a chronological account of the integration of innovation and technology within medical simulation and training from 2014 to 2023 at Torbay and South Devon NHS Foundation Trust (TSDFT). Responding to the backdrop of a constantly changing technological and clinical (epidemiological) landscape, it seeks to develop a methodology for assessing the role of technology in improving medical simulation and training. The research critically challenges the current trend towards high-fidelity simulations, driven by manufacturers' technology-centric marketing strategies that frequently impose cost constraints and limit perceived educational outcomes. Motivated by the Francis Report's (2013) findings, this practice-based study explores the …

Postmortem-Derived Ipsc Models In Substance Use Disorders Research, Emily Frances Mendez, Consuelo Walss-Bass

Faculty, Staff and Student Publications

No abstract provided.

Development Of 3d Cell Culture Model For Graves’ Ophthalmopathy, Rajit Chompoowong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Orbital tissue fibrosis and remodeling contribute to the development of exophthalmos, a hallmark symptom of Graves’ ophthalmopathy (GO). The central pathogenesis to this process are orbital fibroblasts (GOF), which express autoantigen, thyroid-stimulating hormone receptor (TSHR). However, there are limitations in preclinical models for studying the pathogenesis and drug discovery of GO, which poses challenges for developing effective treatment options. This study aimed to identify markers of GOF, explore epigenetic alteration, and develop a scaffold-free 3D cell culture model for GO. The novel results from immunohistochemical analysis showed that vimentin was uniquely expressed in GO but absent in control samples. Additionally, …

Tigra Scientifica, Full Issue

Tigra scientifica

Tigra scientifica, showcasing the outstanding work by Clemson University students in the Creative Inquiry course Popular Science Journalism. Science and technology shape our world in profound ways — from the rise of space tourism to the rapid development of new medical treatments. In a democracy, communicating science is essential for informed debate and decision-making, a responsibility these students have embraced with energy and skill. The magazine began in Spring 2011 under Holly Tuten, Ph.D., who founded the CI course to pass along her passion for science writing. Since then, more than 200 students from 14 majors across five colleges have …

Evaluating Native American Serving Nontribal Institutions (Nasnti) Admissions Criteria To Create An Inclusive Nursing Workforce, Tori Stanek

Antioch University Dissertations & Theses

The national nursing shortage is projected to increase as the bulk of the United States population ages out of the workforce and is likely to require more age-related healthcare services. The lack of ethnic, racial, and gender-based diversity in the current workforce exacerbates this shortage, and the need for a diversified workforce acknowledged by governing nursing bodies from as early as 2011 is still largely unmet. This study looks to nursing programs—specifically their application processes—as one factor that contributes to workforce disparities. Guided by several tenets of Tribalcrit Theory (Brayboy, 2005) and the Triarchic Theory of Intelligence (Sternberg, 1985), this …

4d Epr Oximetry Imaging For 4d Bioprinting And Tissue Engineering, Sajad Sarvari

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioprinting, akin to 3D printing, employs cell-laden hydrogels such as GelMA (Gelatine Methacrylate) and Alginate instead of plastic or resin to create biological structures. The printing process followed by subsequent tissue maturation is known as 4D bioprinting, where the fourth dimension is time. Ensuring adequate and consistent oxygen, O2, supply within 3D bioprint volume over the entire maturation period process is crucial, as even transient hypoxia can impact cellular behavior and phenotypes. However, printing of fully developed vasculature remains an unresolved technical challenge. Several approaches to chemically (peroxides) or biologically (photosynthesis) generate oxygen during bioprint maturation have been proposed. However, …

In Defense Of The “Peculiar Institution”: The Influence Of European Scientific Racism On The Confederacy, Guillem Colom

The Gettysburg Historical Journal

Through the antebellum period and American Civil War, American and European race theorists exchanged ideas through correspondence and scientific explorations asserting the truth of scientific racism. Scientific racist beliefs posited the natural superiority of white people and inferiority of Black people based on what these theorists claimed were innate biological characteristics, and these beliefs served as a critical linkage between Europe and the United States. Utilizing correspondence and journal entries, this paper shows that this exchange of scientific racist ideas significantly influenced the Confederacy’s political thought and policy positions, especially foreign relations, through the Civil War. Through the work of …

Gettysburg Historical Journal 2024

The Gettysburg Historical Journal

Complete Issue of the Gettysburg Historical Journal 2024

Meta-Analysis Of The Vmp-Like Sequences Of Lyme Disease Borrelia: Evidence For The Evolution Of An Elaborate Antigenic Variation System, Steven J Norris, Kalvis Brangulis

Faculty, Staff and Student Publications

VMP-like sequence (vls) antigenic variation systems are present in every Lyme disease Borrelia strain with complete genome sequences. The linear plasmid-encoded vls system consists of a single expression site (vlsE) and contiguous array(s) of silent cassettes that have ~90% identity with the central cassette region of the cognate vlsE gene; antigenic variation occurs through random, segmental, and unidirectional recombination of vls silent cassette sequences into the vlsE expression site. Automated annotation programs do not accurately recognize vls silent cassette sequences, so these regions are not correctly annotated in most genomic sequences. In this study, the vls …

In Vivo Measurement Of Nadh Fluorescence Lifetime In Skeletal Muscle Via Fiber-Coupled Time-Correlated Single Photon Counting, Kathryn M. Priest, Jacob V. Schluns, Nathania Nischal, Colton L. Gattis, Jeffery C. Wolchok, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Nicotinamide adenine dinucleotide (NADH) is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation (OXPHOS). NADH is autofluorescent, and its fluorescence lifetime can be used to infer metabolic dynamics in living cells. Fiber-coupled time-correlated single photon counting (TCSPC) equipped with an implantable needle probe can be used to measure NADH lifetime in vivo, enabling investigation of changing metabolic demand during muscle contraction or tissue regeneration. This study illustrates a proof of concept for point-based, minimally-invasive NADH fluorescence lifetime measurement in vivo. Volumetric muscle loss (VML) injuries were …

Comparative Analysis Of Smartwatch Data In Children With Adhd And Non-Adhd, Friederike Hicking

Open Access Master's Theses

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity, which often lead to significant challenges in academic and social settings. Diagnostic methods for ADHD rely on subjective assessments which are prone to bias. Researchers have explored technology-based objective assessment methods to help diagnose ADHD. In particular, this thesis investigates behavioral differences between children with ADHD and neurotypical children (6-11 years old) using smartwatch data collected from both hands during various classroom-like activities including drawing, math and English worksheets, and magnetic tiles puzzles. The primary objective is to identify distinct behavioral patterns to enhance …

New Treatment Modality For Metastatic Cancer By Targeting The Endothelin Type A Receptor (Etar), Elbara Fathelrahman Abdelmoula

Theses

Ambrisentan, an FDA-approved selective antagonist of the Endothelin Type A Receptor (ETAR) for pulmonary arterial hypertension, has shown potential in limiting cancer growth and metastasis. While effective treatment options for melanoma remain elusive, this study investigates the effects of Ambrisentan on invasive, metastatic B16F10 melanoma using a syngeneic mouse model, aiming to assess Ambrisentan’s impact on tumor growth, metastasis, and overall host survival in B16F10 melanoma, along with gaining mechanistic insights into ETAR antagonism. C57Bl/6 mice were divided into two groups, receiving either dH2O or Ambrisentan orally. Treatments commenced prior to tumor implantation and continued post-implantation. Luciferase-expressing B16F10 cells facilitated …

Sound Marks, Deborah R. Gerhardt, Jon J. Lee

Faculty Publications

A lion roars just before a film rolls. A doughboy giggles. A giant green man laughs a hearty, "Ho, Ho, Ho." These iconic sounds are all federally registered as trademarks. They identify specific brands and distinguish their products and services from the competition. Human brains treat sounds like these as categorization tools and cognitive shortcuts—ideal trademark symbols. But what about the sounds your favorite toys or electronic devices make? Or those made by a fictional character in the latest blockbuster?

This Article tackles these issues and others. We push back against the widely-held belief that all unconventional trademarks—product designs, colors, …

Does Alzheimer’S Disease Begin In Your Gut? A Review Of The Gut-Brain Axis Effect On Cognitive Impairment And The Potential For Therapeutic Targeted Interventions., Jane Greenberg

Theses

Objective: To summarize current data regarding the bidirectional communication of the gut microbiota and the brain, specifically in relation to cognitive improvement, microbiota diversity, and dietary interventions. Additionally, the mechanisms underlying these relationships will be explored. Evidence Acquisition: Using the key terms “gut-brain axis" and "Alzheimer’s disease” PubMed and Web of Science were searched for papers published between 2014 and 2023. This yielded 297 results, of which 23 were relevant to this topic. Articles that failed to address cognitive impairment or only studied animal subjects were excluded. After scanning each paper, nine review articles and 14 new studies were selected …

Meta-Analysis Of Postoperative Myocardial Injury As A Predictor Of Mortality After Living Donor Liver Transplantation, Krzysztof Jankowski, Frank W Peacock, Michal Pruc, Teresa Malecka-Massalska, Lukasz Szarpak

Faculty, Staff and Students Publications

BACKGROUND: The purpose of this study was to perform a systematic review and meta-analysis to investigate postoperative myocardial injury, as expressed by the postoperative concentration of high-sensitivity cardiac troponin I (hs-cTnI) as a predictor of mortality among living donor liver transplantation (LDLT) patients.

METHODS: PubMed, Scopus, Embase and the Cochrane Library were searched through to September 1st 2022. The primary endpoint included in-hospital mortality. Secondary endpoints were 1-year mortality and re-transplantation occurrence. Estimates are expressed as risk ratios (RRs) and 95% confidence intervals (95% CIs). Heterogeneity was assessed with the I² test.

RESULTS: During the search, 2 studies were found …

The Maternal Gut Microbiome In Pregnancy: Implications For The Developing Immune System, Omry Koren, Liza Konnikova, Petter Brodin, Indira U Mysorekar, Maria Carmen Collado

Faculty, Staff and Students Publications

The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breastfeeding provide critical sources of early-life microbial and immune training, with important consequences for human health. Only a few studies have directly examined the interactions between the gut microbiome and the immune system during pregnancy, and the subsequent effect on offspring development. In this Review, we aim to describe how the maternal microbiome shapes overall pregnancy-associated maternal, fetal and early neonatal …

Green Synthesis Of Zinc Oxide Nanoparticles From Althaea Officinalis Flower Extract Coated With Chitosan For Potential Healing Effects On Diabetic Wounds By Inhibiting Tnf-Α And Il-6/Il-1Β Signaling Pathways, Sammar Fathy Elhabal, Nashwa Abdelaal, Saeed Abdul Kareem Saeed Al-Zuhairy, Mohamed Fathi Mohamed Elrefai, Ahmed Mohsen Elsaid Hamdan, Mohamed Mansour Khalifa, Sandra Hababeh, Mohammad Ahmad Khasawneh, Gehad M Khamis, Jakline Nelson, Passant M Mohie, Rania A Gad, Amira Rizk, Soad L Kabil, Mohamed Kandeel El-Ashery, Bhaskara R Jasti, Nahla A Elzohairy, Tayseer Elnawawy, Fatma E Hassan, Mohamed A El-Nabarawi

Faculty, Staff and Students Publications

BACKGROUND: Diabetes Mellitus is a multisystem chronic pandemic, wound inflammation, and healing are still major issues for diabetic patients who may suffer from ulcers, gangrene, and other wounds from uncontrolled chronic hyperglycemia.

METHOD AND RESULTS: First, develop eco-friendly green Zinc Oxide Nanoparticles (ZnO-NPs) and incorporate them into a 2% chitosan (CS) gel. In-vitro study performed by UV-visible spectrum analysis showed a sharp peak at 390 nm, and Energy-dispersive X-ray (EDX) spectrometry showed a peak of zinc and oxygen. Besides, Fourier transforms infrared (FTIR) was used to qualitatively validate biosynthesized ZnO-NPs, and transmission electron microscope (TEM) showed spherical nanoparticles with mean …

Revolutionizing Psoriasis Topical Treatment: Enhanced Efficacy Through Ceramide/Phospholipid Composite Cerosomes Co-Delivery Of Cyclosporine And Dithranol: In-Vitro, Ex-Vivo, And In-Vivo Studies, Sammar Fathy Elhabal, Nashwa Abdelaal, Saeed A S Al-Zuhairy, Mohamed Fathi Mohamed Elrefai, Mohamed Mansour Khalifa, Mohammad Ahmad Khasawneh, Ahmed Mohsen Elsaid Hamdan, Passant M Mohie, Rania A Gad, Soad L Kabil, Mohamed Kandeel El-Ashery, Bhaskara R Jasti, Nahla A Elzohairy, Nehal Elfar, Tayseer Elnawawy, Fatma E Hassan, Mohamed Ahmed El-Nabarawi

Faculty, Staff and Students Publications

PURPOSE: Improving the treatment of psoriasis is a serious challenge today. Psoriasis is an immune-mediated skin condition affecting 125 million people worldwide. It is commonly treated with cyclosporine-A (CsA) and dithranol (DTH). CsA suppresses the activation of T-cells, immune cells involved in forming psoriatic lesions. Meanwhile, DTH is a potent anti-inflammatory and anti-proliferative drug that effectively reduces the severity of psoriasis symptoms such as redness, scaling, and skin thickness. CsA and DTH belong to BCS class II with limited oral bioavailability. We aim to develop a drug delivery system for topical co-delivery of CsA and DTH, exploring its therapeutic potential. …

Drosophila Parasitoids Go To Space: Unexpected Effects Of Spaceflight On Hosts And Their Parasitoids, Jennifer Chou, Johnny R. Ramroop, Amanda M. Saravia-Butler, Brian Wey, Matthew P. Lera, Medaya L. Torres, Mary Ellen Heavner, Janani Iyer, Siddhita D. Mhatre, Sharmila Bhattacharya, Shubha Govind

Publications and Research

While fruit flies (Drosophila melanogaster) and humans exhibit immune system dysfunction in space, studies examining their immune systems’ interactions with natural parasites in space are lacking. Drosophila parasitoid wasps modify blood cell function to suppress host immunity. In this study, naive and parasitized ground and space flies from a tumor-free control and a blood tumor-bearing mutant strain were examined. Inflammation-related genes were activated in space in both fly strains. Whereas control flies did not develop tumors, tumor burden increased in the space-returned tumor-bearing mutants. Surprisingly, control flies were more sensitive to spaceflight than mutant flies; many of their …

Traf4-Mediated Nonproteolytic Ubiquitination Of Androgen Receptor Promotes Castration-Resistant Prostate Cancer, Yosi Gilad, Ortal Shimon, Sang Jun Han, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Steroid receptor coactivators (SRCs) are master regulators of transcription that play key roles in human physiology and pathology. SRCs are particularly important for the regulation of the immune system with major roles in lymphocyte fate determination and function, macrophage activity, regulation of nuclear factor κB (NF-κB) transcriptional activity and other immune system biology. The three members of the p160 SRC family comprise a network of immune-regulatory proteins that can function independently or act in synergy with each other, and compensate for - or moderate - the activity of other SRCs. Recent evidence indicates that the SRCs are key participants in …

Steroid Receptor Coactivators In Treg And Th17 Cell Biology And Function, Yosi Gilad, Ortal Shimon, Sang Jun Han, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Steroid receptor coactivators (SRCs) are master regulators of transcription that play key roles in human physiology and pathology. SRCs are particularly important for the regulation of the immune system with major roles in lymphocyte fate determination and function, macrophage activity, regulation of nuclear factor κB (NF-κB) transcriptional activity and other immune system biology. The three members of the p160 SRC family comprise a network of immune-regulatory proteins that can function independently or act in synergy with each other, and compensate for - or moderate - the activity of other SRCs. Recent evidence indicates that the SRCs are key participants in …

Taking Environmental Responsibility Seriously: Academic Libraries, Ai, And Climate Impacts, Frank Houghton, Jennifer Moran Stritch, Lisa O'Rourke Scott

Library Philosophy and Practice (e-journal)

Generative AI is a disruptive technology that offers significant potential across many fields including healthcare, health education and academic libraries. However, although many concerns are routinely cited in relation to AI, very few of these address the issue of the increased power requirements inherent in AI training and inference. Climate change resulting from human factors has already resulted in increased global warming and climate variability. In this Anthropocene era the question must be asked how libraries and other organisations will mitigate the impacts of their increased AI use? To date assessments of sustainability and energy use in libraries have not …