Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (27228)
- Social and Behavioral Sciences (12295)
- Medical Specialties (9495)
- Life Sciences (8368)
- Education (8019)
-
- Medical Sciences (6592)
- Law (5174)
- Arts and Humanities (4742)
- Physical Sciences and Mathematics (4357)
- Public Health (4182)
- Psychology (3283)
- Engineering (2923)
- Oncology (2775)
- Diseases (2658)
- Biomedical Informatics (2631)
- Nursing (2504)
- Bioinformatics (2245)
- Higher Education (2226)
- Business (2179)
- Sociology (2103)
- Medical Education (1742)
- Medical Genetics (1631)
- Public Affairs, Public Policy and Public Administration (1589)
- Mental and Social Health (1566)
- Rehabilitation and Therapy (1461)
- Environmental Sciences (1336)
- Genetic Phenomena (1273)
- Health and Physical Education (1101)
- Pediatrics (1084)
- Computer Sciences (1082)
- Institution
-
- The Texas Medical Center Library (6001)
- University of South Florida (1905)
- Washington University School of Medicine (1707)
- Walden University (1580)
- University of Montana (1502)
-
- Sigma Theta Tau International Honor Society of Nursing (1285)
- Liberty University (1233)
- University of Kentucky (1216)
- Chulalongkorn University (1215)
- University of Texas Rio Grande Valley (1091)
- Thomas Jefferson University (986)
- University of Nebraska - Lincoln (985)
- University of Plymouth (838)
- University of South Carolina (786)
- Western Kentucky University (761)
- University of New Hampshire (739)
- Universitas Indonesia (733)
- Advocate Health - Midwest (715)
- Edith Cowan University (713)
- Utah State University (705)
- University of Arkansas, Fayetteville (679)
- Nova Southeastern University (674)
- American Dental Association (630)
- HCA Healthcare (607)
- Portland State University (573)
- LSU Health New Orleans (570)
- Brigham Young University (560)
- City University of New York (CUNY) (553)
- University of New Mexico (548)
- Louisiana State University (532)
- Keyword
-
- Humans (5643)
- Female (2810)
- Male (2457)
- Animals (1649)
- Adult (1490)
-
- ICTS (Institute of Clinical and Translational Sciences) (1421)
- Middle Aged (1398)
- Aged (1185)
- Mice (1127)
- COVID-19 (889)
- Child (740)
- Mental health (708)
- Education (675)
- Adolescent (665)
- United States (560)
- Retrospective Studies (490)
- Young Adult (455)
- Depression (425)
- Neoplasms (400)
- Treatment Outcome (398)
- Pregnancy (365)
- Biomarkers (357)
- Health (357)
- Anxiety (348)
- Infant (345)
- Machine learning (343)
- Risk Factors (342)
- Mutation (336)
- Artificial intelligence (328)
- Tumor (327)
- Publication
-
- Faculty, Staff and Student Publications (3557)
- Faculty, Staff and Students Publications (1924)
- Theses and Dissertations (1764)
- 2020-Current year OA Pubs (1690)
- Walden Dissertations and Doctoral Studies (1508)
-
- University of Montana Course Syllabi, 2021-2025 (1149)
- Doctoral Dissertations and Projects (937)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (813)
- The Auk (791)
- Dissertations (765)
- Electronic Theses and Dissertations (690)
- Research outputs 2022 to 2026 (660)
- Faculty Publications (632)
- Leadership Connection (551)
- International Journal of Exercise Science: Conference Proceedings (524)
- Faculty Scholarship (493)
- Historical Documents - Combined (417)
- Honors Theses (393)
- Theses (354)
- Silver Bow Creek/Butte Area Superfund Site (323)
- Articles (317)
- USF Tampa Graduate Theses and Dissertations (297)
- School of Medicine Faculty Publications (295)
- Research Symposium (277)
- Master's Theses (271)
- Patient Education Projects (255)
- 2024 Decisions (251)
- DRS Biennial Conference Series (249)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (236)
- International Journal of Physical Activity and Health (233)
- Publication Type
Articles 5341 - 5370 of 79782
Full-Text Articles in Entire DC Network
Machine Learning Optimized Depolymerization Of Pet (Polyethylene Terephthalate) Via Glycolysis, Mehwash Aamir
Machine Learning Optimized Depolymerization Of Pet (Polyethylene Terephthalate) Via Glycolysis, Mehwash Aamir
Theses and Dissertations
Over 90% of the approximately 1 million PET bottles sold every minute end up in landfills or oceans, where they can persist for centuries. Plastic pollution urgently needs sustainable management and recycling solutions to mitigate the environmental impact of PET waste. From all techniques to recycle plastic waste, catalytic glycolysis stands out for its rapid reaction time, high monomer yields, lower costs, and enhanced durability.
In this work glycolysis of PET was evaluated under microwave conditions using 1,5,7-Triazabicyclo [4.4.0] dec5-ene (TBD) and 1,8-Diazabicyclo [5.4.0] undec-7-ene (DBU) as catalysts, being DBU as the best catalyst for further analysis. The effect of …
Exploring The Potential Of Epiregulin And Amphiregulin As Prognostic, Predictive, And Therapeutic Targets In Colorectal Cancer, Cara Guernsey-Biddle, Peyton High, Kendra S Carmon
Exploring The Potential Of Epiregulin And Amphiregulin As Prognostic, Predictive, And Therapeutic Targets In Colorectal Cancer, Cara Guernsey-Biddle, Peyton High, Kendra S Carmon
The Brown Foundation: Institute of Molecular Medicine
The epidermal growth factor receptor (EGFR) plays a critical role in regulating essential cellular processes that are frequently hijacked to promote cancer. In colorectal cancer (CRC) in particular, the EGFR signaling pathway is frequently hyperactivated via receptor and/or ligand overexpression and downstream oncogenic mutations. Current EGFR-targeted therapies for metastatic CRC (mCRC) include the monoclonal antibodies (mAbs) cetuximab and panitumumab. However, intrinsic and acquired resistance to EGFR-targeted mAbs are commonly observed. Thus, additional biomarkers are necessary to better understand patient sensitivity to EGFR-targeted therapies. Furthermore, therapeutic targeting of alternative EGFR pathway components may serve as one mechanism to overcome EGFR-targeted mAb …
Three Decades Of Rat Genomics: Approaching The Finish(Ed) Line, Theodore S Kalbfleisch, Melissa L Smith, Julia L Ciosek, Kai Li, Peter A Doris
Three Decades Of Rat Genomics: Approaching The Finish(Ed) Line, Theodore S Kalbfleisch, Melissa L Smith, Julia L Ciosek, Kai Li, Peter A Doris
The Brown Foundation: Institute of Molecular Medicine
The rat, Rattus norvegicus, has provided an important model for investigation of a range of characteristics of biomedical importance. Here we survey the origins of this species, its introduction into laboratory research, and the emergence of genetic and genomic methods that utilize this model organism. Genomic studies have yielded important progress and provided new insight into several biologically important traits. However, some studies have been impeded by the lack of a complete and accurate reference genome for this species. New sequencing and genome assembly methods applied to the rat have resulted in a new reference genome assembly, GRCr8, which …
Anxiety-Like Behaviors In Mice Unmasked: Revealing Sex Differences In Anxiety Using A Novel Light-Heat Conflict Test, Sydney E Lee, Sung-Hoon Park, John C Aldrich, Laura K Fonken, Andrew D Gaudet
Anxiety-Like Behaviors In Mice Unmasked: Revealing Sex Differences In Anxiety Using A Novel Light-Heat Conflict Test, Sydney E Lee, Sung-Hoon Park, John C Aldrich, Laura K Fonken, Andrew D Gaudet
The Brown Foundation: Institute of Molecular Medicine
Anxiety and chronic pain afflict hundreds of millions worldwide. Anxiety and pain are more prevalent in females compared to males. Unfortunately, robust sex differences in human anxiety are not recapitulated in rodent tests, and results from rodent pain studies frequently fail to translate clinically. Therefore, there is a need to develop tests that reflect the differential salience of anxiety or pain-related stimuli between the sexes. Accordingly, here we introduce the Thermal Increments Dark-Light (TIDAL) conflict test. The TIDAL test places an anxiety-relevant stimulus (dark vs. illuminated chamber) in conflict with a heat-related stimulus (incrementally heated vs. isothermic chamber); mice freely …
Aid Or Abuse? A Review Of U.S. Police Assistance Programs In Latin America During The Early Cold War, Brianna Mcnally
Aid Or Abuse? A Review Of U.S. Police Assistance Programs In Latin America During The Early Cold War, Brianna Mcnally
War, Diplomacy, and Society (MA) Theses
During the Cold War, the United States used police assistance programs in under-developed countries to stop the spread of communism. Police aid aimed to improve a country’s economic stability and internal security to curb the rise of communist revolutions. The U.S. government charged the Office of Public Safety (OPS) within the U.S. Agency for International Development (USAID) with managing police assistance programs around the world, including in Asia, Africa, and Latin America.
Despite its seemingly good intentions, the OPS became a short-lived program now known today for its ties to human rights abuses, especially throughout Latin America. Several Latin American …
U.S. Supreme Court Argument In U.S. V. Skrmetti Does Not Generate Optimism For Reversal Of The 6th Circuit, Arthur S. Leonard
U.S. Supreme Court Argument In U.S. V. Skrmetti Does Not Generate Optimism For Reversal Of The 6th Circuit, Arthur S. Leonard
Other Publications
No abstract provided.
An Update On Novel Taxa And Revised Taxonomic Status Of Bacteria Isolated From Domestic Companion And Agricultural Animals Described In 2023, Sara D. Lawhon, Claire R. Burbick, Trinity Kreuger, Elena Ruiz-Reyes, Erik Munson
An Update On Novel Taxa And Revised Taxonomic Status Of Bacteria Isolated From Domestic Companion And Agricultural Animals Described In 2023, Sara D. Lawhon, Claire R. Burbick, Trinity Kreuger, Elena Ruiz-Reyes, Erik Munson
Clinical Lab Sciences Faculty Research and Publications
With the proliferation of abundant bacterial genomic data comes the recognition of new organisms as well as a better understanding of the relatedness of known bacteria. Recognizing the associated taxonomic changes enhances communication and understanding about the significance of novel organisms and deeper understanding of known pathogens. This review addresses the addition of multiple gastrointestinal bacteria that form the normal microbiota in a variety of animals including honeybees as well as novel bacteria from domestic animals including an alpha-hemolytic Streptococcus species from guinea pigs, two Moraxella spp. from cows and goats, a new Capnocytophaga species from cats, a thermophilic Campylobacter …
Recovery Resiliency Of Interdependent Power Systems Infrastructure Subject To Extreme Events, Partha P. Sarker
Recovery Resiliency Of Interdependent Power Systems Infrastructure Subject To Extreme Events, Partha P. Sarker
Graduate Theses and Dissertations (2019 - present)
When Hurricane Maria struck the island of Puerto Rico on September 20, 2017, it devastated the island’s aging power systems infrastructure and inflicted an island-wide power outage that left Puerto Rico in total darkness for an entire week before the system slowly started to recover. This unprecedented failure of the critical power systems infrastructure exacerbated the failure of other critical infrastructures or lifeline systems of the island. This research explores and quantifies the relationships or interdependencies that exist between the power systems and other critical infrastructure systems by investigating the post-hurricane recovery data of these lifeline systems. Subsequently, the research …
Seventh Circuit Panel Overturns Preliminary Injunction Against Indiana Ban On Gender-Affirming Care For Minors, Arthur S. Leonard
Seventh Circuit Panel Overturns Preliminary Injunction Against Indiana Ban On Gender-Affirming Care For Minors, Arthur S. Leonard
Other Publications
No abstract provided.
Covid-19 Risk Assessment Among Vulnerable Small Business Owners In El Paso County, Texas, Sadie H Conway, Denise Vasquez, Kristina D Mena, Louis D Brown, Soyoung Kwon, Janelle Rios
Covid-19 Risk Assessment Among Vulnerable Small Business Owners In El Paso County, Texas, Sadie H Conway, Denise Vasquez, Kristina D Mena, Louis D Brown, Soyoung Kwon, Janelle Rios
Faculty, Staff and Student Publications
Background: Our objective was to deliver actionable, worksite-specific COVID-19 risk assessments and mitigation strategies tailored to vulnerable workers in one of the highest-risk areas in the US.
Methods: Four trained, bilingual (English/Spanish) community health workers (CHWs) recruited small businesses (ie, ≤20 employees) across various industries and executed novel on-site infectious disease risk assessment surveys of at least one employer and one employee.
Results: Of 102 participating businesses (95% Hispanic-owned), 96% were characterized as "high risk" or "very high risk" for disease transmission. All businesses reported implementing at least one practice to reduce disease transmission; however, almost half of businesses lacked …
Bivariate Genome-Wide Association Study Of Circulating Fibrinogen And C-Reactive Protein Levels, Julie Hahn, Gerard Temprano-Sagrera, Natalie R Hasbani, Symen Ligthart, Abbas Dehghan, Alisa S Wolberg, Nicholas L Smith, Maria Sabater-Lleal, Alanna C Morrison, Paul S De Vries
Bivariate Genome-Wide Association Study Of Circulating Fibrinogen And C-Reactive Protein Levels, Julie Hahn, Gerard Temprano-Sagrera, Natalie R Hasbani, Symen Ligthart, Abbas Dehghan, Alisa S Wolberg, Nicholas L Smith, Maria Sabater-Lleal, Alanna C Morrison, Paul S De Vries
Faculty, Staff and Student Publications
Background: Fibrinogen and C-reactive protein (CRP) play an important role in inflammatory pathways and share multiple genetic loci reported in previously published genome-wide association studies (GWAS), highlighting their common genetic background. Leveraging the shared biology may identify further loci pleiotropically associated with both fibrinogen and CRP.
Objectives: To identify novel genetic variants that are pleiotropic and associated with both fibrinogen and CRP, by integrating both phenotypes in a bivariate GWAS by using a multitrait GWAS.
Methods: We performed a bivariate GWAS to identify further pleiotropic genetic loci, using summary statistics of previously published GWAS on fibrinogen (n = 120 246) …
The Association Between Care Integration And Care Quality, Micah B Aaron, Michaela Kerrissey, Zhanna Novikov, Maike V Tietschert, Adam Scherling, Hassina Bahadurzada, Russell S Phillips, Anna D Sinaiko, Sara J Singer
The Association Between Care Integration And Care Quality, Micah B Aaron, Michaela Kerrissey, Zhanna Novikov, Maike V Tietschert, Adam Scherling, Hassina Bahadurzada, Russell S Phillips, Anna D Sinaiko, Sara J Singer
Faculty, Staff and Student Publications
Objective: The study aims to analyze the relationship between care integration and care quality, and to examine if the relationship varies by patient risk.
Data sources and study setting: The key independent variables used validated measures derived from a provider survey of functional (i.e., administrative and clinical systems) and social (i.e., patient integration, professional cooperation, professional coordination) integration. Survey responses represented data from a stratified sample of 59 practice sites from 17 health systems. Dependent variables included three quality measures constructed from patient-level Medicare data: colorectal cancer screening among patients at risk, patient-level 30-day readmission, and a practice-level Healthcare Effectiveness …
Identification Of Proteins Associated With Type 2 Diabetes Risk In Diverse Racial And Ethnic Populations, Shuai Liu, Jingjing Zhu, Hua Zhong, Chong Wu, Haoran Xue, Burcu F Darst, Xiuqing Guo, Peter Durda, Russell P Tracy, Yongmei Liu, W Craig Johnson, Kent D Taylor, Ani W Manichaikul, Mark O Goodarzi, Robert E Gerszten, Clary B Clish, Yii-Der Ida Chen, Heather Highland, Christopher A Haiman, Christopher R Gignoux, Leslie Lange, David V Conti, Laura M Raffield, Lynne Wilkens, Loïc Le Marchand, Kari E North, Kristin L Young, Ruth J Loos, Steve Buyske, Tara Matise, Ulrike Peters, Charles Kooperberg, Alexander P Reiner, Bing Yu, Eric Boerwinkle, Quan Sun, Mary R Rooney, Justin B Echouffo-Tcheugui, Martha L Daviglus, Qibin Qi, Nicholas Mancuso, Changwei Li, Youping Deng, Alisa Manning, James B Meigs, Stephen S Rich, Jerome I Rotter, Lang Wu
Identification Of Proteins Associated With Type 2 Diabetes Risk In Diverse Racial And Ethnic Populations, Shuai Liu, Jingjing Zhu, Hua Zhong, Chong Wu, Haoran Xue, Burcu F Darst, Xiuqing Guo, Peter Durda, Russell P Tracy, Yongmei Liu, W Craig Johnson, Kent D Taylor, Ani W Manichaikul, Mark O Goodarzi, Robert E Gerszten, Clary B Clish, Yii-Der Ida Chen, Heather Highland, Christopher A Haiman, Christopher R Gignoux, Leslie Lange, David V Conti, Laura M Raffield, Lynne Wilkens, Loïc Le Marchand, Kari E North, Kristin L Young, Ruth J Loos, Steve Buyske, Tara Matise, Ulrike Peters, Charles Kooperberg, Alexander P Reiner, Bing Yu, Eric Boerwinkle, Quan Sun, Mary R Rooney, Justin B Echouffo-Tcheugui, Martha L Daviglus, Qibin Qi, Nicholas Mancuso, Changwei Li, Youping Deng, Alisa Manning, James B Meigs, Stephen S Rich, Jerome I Rotter, Lang Wu
Faculty, Staff and Student Publications
Aims/hypothesis: Several studies have reported associations between specific proteins and type 2 diabetes risk in European populations. To better understand the role played by proteins in type 2 diabetes aetiology across diverse populations, we conducted a large proteome-wide association study using genetic instruments across four racial and ethnic groups: African; Asian; Hispanic/Latino; and European.
Methods: Genome and plasma proteome data from the Multi-Ethnic Study of Atherosclerosis (MESA) study involving 182 African, 69 Asian, 284 Hispanic/Latino and 409 European individuals residing in the USA were used to establish protein prediction models by using potentially associated cis- and trans-SNPs. The models were …
Perceived Stigma's Influence On The Association Between Suicide Risk Severity And Help-Seeking For Suicidal Crises, Donna Zastrow
Perceived Stigma's Influence On The Association Between Suicide Risk Severity And Help-Seeking For Suicidal Crises, Donna Zastrow
Electronic Theses and Dissertations
Introduction: Unfortunately, research examining help-seeking for suicide is limited. This study examined age, race, gender, suicide risk severity, and perceived stigma as predictors of formal and informal help-seeking behaviors individuals engage in during suicidal crises, and explored perceived stigma as a moderator of the relationship between risk severity and help-seeking. Method: Data from 80 college students who had experienced a past suicidal crisis were analyzed using two moderation analyses. Results: Rates of formal (67.5%) and informal (86.2%) help-seeking were high in the study sample. Higher suicide risk severity was positively associated with formal help-seeking (b = …
December 2024, Swosu Bulldog Wellness Committee
December 2024, Swosu Bulldog Wellness Committee
SWOSU BULLDOG WELLNESS
December is Healthy Eating Month
- Eating a variety of foods, including vegetables, fruits, and whole-grain products
- Eating lean meats, poultry, fish, beans, and low-fat dairy products
- Getting enough fiber
- Drinking lots of water
- Limiting salt, added sugars, alcohol, and saturated fat
- Making sure that you get enough nutrients, especially calcium, vitamin D, and potassium
Designing A Blockchain Technology Platform For Enhancing The Pre-Exposure Prophylaxis Care Continuum, Anjum Khurshid, Daniel Toshio Harrell, Dennis Li, Camden Hallmark, Ladd Hanson, Nishi Viswanathan, Michelle Carr, Armand Brown, Marlene Mcneese, Kayo Fujimoto
Designing A Blockchain Technology Platform For Enhancing The Pre-Exposure Prophylaxis Care Continuum, Anjum Khurshid, Daniel Toshio Harrell, Dennis Li, Camden Hallmark, Ladd Hanson, Nishi Viswanathan, Michelle Carr, Armand Brown, Marlene Mcneese, Kayo Fujimoto
Faculty, Staff and Student Publications
OBJECTIVES: Pre-exposure prophylaxis (PrEP) is a key biomedical intervention for ending the HIV epidemic in the United States, but its uptake is impeded by systemic barriers, including fragmented workflows and ineffective data coordination. This study aims to design PrEPLinker, a blockchain-based, client-centered platform to enhance care to address these challenges by improving care coordination and enabling clients to securely manage their identity and PrEP-related data.
MATERIALS AND METHODS: Using Houston, Texas, as a use case, we conducted a needs assessment with PrEP collaborators to evaluate existing workflows and identify barriers in the PrEP care continuum. Based on these findings, we …
Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project;, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso
Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project;, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso
Faculty, Staff and Student Publications
INTRODUCTION: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.
METHODS: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data.
RESULTS: Pooled-population analyses of all individuals identified genetic variants at apolipoprotein E (APOE) and BIN1 associated with AD (p < 5 × 10
DISCUSSION: We observed that complementary pooled-population and subgroup-specific analyses offered unique insights into the genetic architecture of AD.
HIGHLIGHTS: We determine the association of genetic variants with Alzheimer's disease (AD) using …
Effectiveness Of Enhanced Care For Treatment Of Acute Or Persistent Diarrhea In Malnourished Children Aged 0 Months To 10 Years: A Systematic Review, Ridwa Alam, Khadija Vadsaria, Ahmad Khan, Uswa Jiwani, Aqsa Ishaq, Anmol Minaz, Ashraf Sharif, Jai K. Das, Sajid Bashir Soofi, Shabina Ariff
Effectiveness Of Enhanced Care For Treatment Of Acute Or Persistent Diarrhea In Malnourished Children Aged 0 Months To 10 Years: A Systematic Review, Ridwa Alam, Khadija Vadsaria, Ahmad Khan, Uswa Jiwani, Aqsa Ishaq, Anmol Minaz, Ashraf Sharif, Jai K. Das, Sajid Bashir Soofi, Shabina Ariff
Centre of Excellence in Women and Child Health
Background: Diarrhea poses a significant public health challenge, particularly affecting children under five. The link between malnutrition and diarrhea is well established, with diarrhea being a primary cause of malnutrition in young children and malnutrition exacerbating the severity of diarrhea. While the World Health Organization (WHO) recommends a comprehensive approach to both diarrhea and malnutrition management, including oral rehydration, continuous feeding, zinc supplementation, and antibiotics for specific strains, it does not adequately address the complex needs of malnourished children with diarrhea who may benefit from enhanced care in the form of follow-up and monitoring beyond initial treatment. We aimed to …
Relative Muscular Effort In The Older Adults During The Sit-To-Stand Task: Monitoring Neuromuscular Reserve And Movement Limitations, Nayun Ahn, Michael H. Haischer, Cara L. Lewis, Kristof Kipp
Relative Muscular Effort In The Older Adults During The Sit-To-Stand Task: Monitoring Neuromuscular Reserve And Movement Limitations, Nayun Ahn, Michael H. Haischer, Cara L. Lewis, Kristof Kipp
Exercise Science Faculty Research and Publications
Background
Due to lower maximum strength, older adults purportedly need to exert greater muscular effort to stand up from a chair. This study investigated joint-specific muscular effort during a sit-to-stand by calculating relative-muscular-effort and investigating differences between healthy older and young adults.
Methods
Fifteen older (age: 69.9 ± 3.5 years) and 15 young (age: 22.2 ± 2.6 years) adults performed five self-paced sit-to-stand trials. Kinematic and kinetic data were collected and used to calculate inverse dynamics net joint moment. Peak isometric knee and hip extensor torques were measured and used as inputs to regression models that predicted angle- and velocity-dependent …
Equitable Community-Based Participatory Research Engagement With Communities Of Color Drives All Of Us Wisconsin Genomic Research Priorities, Sheikh Iqbal Ahamed, Praveen Madiraju
Equitable Community-Based Participatory Research Engagement With Communities Of Color Drives All Of Us Wisconsin Genomic Research Priorities, Sheikh Iqbal Ahamed, Praveen Madiraju
Computer Science Faculty Research and Publications
Objective
The NIH All of Us Research Program aims to advance personalized medicine by not only linking patient records, surveys, and genomic data but also engaging with participants, particularly from groups traditionally underrepresented in biomedical research (UBR). This study details how the dialogue between scientists and community members, including many from communities of color, shaped local research priorities.
Materials and Methods
We recruited area quantitative, basic, and clinical scientists as well as community members from our Community and Participant Advisory Boards with a predetermined interest in All of Us research as members of a Special Interest Group (SIG). An expert …
Behaviorism Literature Review On School Suspension And The School To Prison Pipeline, Joelle Tidwell
Behaviorism Literature Review On School Suspension And The School To Prison Pipeline, Joelle Tidwell
Curriculum and Instruction Undergraduate Honors Theses
An analysis of the current body of research about the school to prison pipeline demonstrates that exclusionary practices are indicators for which students will encounter the criminal justice system in their youth and adulthood. Moreover, exclusionary practices are associated with a variety of other negative outcomes such as poor mental health, poor physical health, and lower wages. This research demonstrates the need for exclusionary practices to be replaced with school-wide behavioral supports that will provide intervention and strategies for students that help keep them in the classroom instead of simply punishing them with isolation.
Vitamin D In Patients With Low Tumor-Burden Indolent Non-Hodgkin Lymphoma Treated With Rituximab Therapy (Ilyad): A Randomized, Phase 3 Clinical Trial, Jonathan W Friedberg, Michael T Brady, Myla Strawderman, Brad S Kahl, Izidore S Lossos, Jonathon B Cohen, Patrick M Reagan, Carla Casulo, Barbara L Averill, Andrea Baran, Grerk Sutamtewagul, Paul M Barr, John P Leonard, John M Ashton, John G Strang, Francisco Vega, Derick R Peterson, Loretta J Nastoupil
Vitamin D In Patients With Low Tumor-Burden Indolent Non-Hodgkin Lymphoma Treated With Rituximab Therapy (Ilyad): A Randomized, Phase 3 Clinical Trial, Jonathan W Friedberg, Michael T Brady, Myla Strawderman, Brad S Kahl, Izidore S Lossos, Jonathon B Cohen, Patrick M Reagan, Carla Casulo, Barbara L Averill, Andrea Baran, Grerk Sutamtewagul, Paul M Barr, John P Leonard, John M Ashton, John G Strang, Francisco Vega, Derick R Peterson, Loretta J Nastoupil
Faculty, Staff and Student Publications
Background: There is a significant association between low vitamin D levels at diagnosis of indolent B-cell lymphomas and inferior overall survival (OS). To determine whether supplemental vitamin D improves event-free survival (EFS) in these patients, we conducted a comparative double-blind study of vitamin D3 vs. placebo.
Methods: In this phase 3, randomized, double-blind, placebo-controlled trial, patients with low tumor burden follicular, marginal zone or small lymphocytic lymphoma, age 18 or older, with stage two or greater disease and no prior systemic treatment were enrolled at 7 academic cancer centers. Patients were stratified by histology and FLIPI (Follicular Lymphoma International Prognostic …
Antiangiogenic Therapy Combined With Immune Checkpoint Blockade In Urothelial Cancer: Systematic Review And Meta-Analysis, Mohammad Jad Moussa, Iuliia Kovalenko, Emanuele Crupi, Ekaterina Proskuriakova, Yimin Geng, Giuseppe Fallara, Raed Benkhadra, Daniele Raggi, Matthew T Campbell, Pavlos Msaouel, Omar Alhalabi
Antiangiogenic Therapy Combined With Immune Checkpoint Blockade In Urothelial Cancer: Systematic Review And Meta-Analysis, Mohammad Jad Moussa, Iuliia Kovalenko, Emanuele Crupi, Ekaterina Proskuriakova, Yimin Geng, Giuseppe Fallara, Raed Benkhadra, Daniele Raggi, Matthew T Campbell, Pavlos Msaouel, Omar Alhalabi
Faculty, Staff and Student Publications
Background: Antiangiogenic therapy had been tested in urothelial cancer (UC) without reaching the clinic.
Objective: We provide a systematic review and meta-analysis of trials to assess efficacy of immune checkpoint inhibitors (ICI) combined with antiangiogenic agents in UC.
Methods: Following PRISMA guidelines, we searched for trials with at least one arm of patients with UC treated with ICI plus antiangiogenics. Data were analyzed with the "meta" package from R using a one-staged frequentist meta-analysis.
Results: After screening 13,708 titles and abstracts, 9 studies were selected for analysis with 14 identified cohorts comprising 621 patients: 448 were ICI-naïve (ICI-N) and 173 …
Early-Stage Extranodal Nk/T-Cell Lymphoma, Nasal Type: A Role For Elective Nodal Irradiation?, Penny Fang, Sonal S Noticewala, Susan Y Wu, Jillian R Gunther, Ethan B Ludmir, L Jeffrey Medeiros, Paolo Strati, Ranjit Nair, Chijioke Nze, Loretta J Nastoupil, Sairah Ahmed, Luis Malpica Castillo, Luis Fayad, Jason Westin, Sattva Neelapu, Christopher Flowers, Auris Huen, Swaminathan P Iyer, Bouthaina Dabaja, Chelsea C Pinnix
Early-Stage Extranodal Nk/T-Cell Lymphoma, Nasal Type: A Role For Elective Nodal Irradiation?, Penny Fang, Sonal S Noticewala, Susan Y Wu, Jillian R Gunther, Ethan B Ludmir, L Jeffrey Medeiros, Paolo Strati, Ranjit Nair, Chijioke Nze, Loretta J Nastoupil, Sairah Ahmed, Luis Malpica Castillo, Luis Fayad, Jason Westin, Sattva Neelapu, Christopher Flowers, Auris Huen, Swaminathan P Iyer, Bouthaina Dabaja, Chelsea C Pinnix
Faculty, Staff and Student Publications
Purpose: Extranodal NK/T-cell lymphoma (ENKTCL) is rare in the Western Hemisphere and is commonly treated with combined modality therapy (CMT).
Methods and materials: We retrospectively reviewed 35 patients treated with Ann Arbor stage I/II ENKTCL between 1994 and 2015 at a large academic cancer center in the United States.
Results: With 11.6 years median follow-up, median overall survival and progression-free survival were 13.5 and 7.5 years, respectively. Eighteen (51%) patients experienced disease relapse, with 5 regional nodal relapses, of which 2 experienced combined regional and distant relapses. All 5 regional nodal relapses occurred exclusively among patients not treated with elective …
Low Intensity Mechanical Signals Promote Proliferation In A Cell-Specific Manner: Tailoring A Non-Drug Strategy To Enhance Biomanufacturing Yields, M Ete Chan, Christopher Ashdown, Lia Strait, Sishir Pasumarthy, Abdullah Hassan, Steven Crimarco, Chanpreet Singh, Vihitaben S Patel, Gabriel Pagnotti, Omor Khan, Gunes Uzer, Clinton T Rubin
Low Intensity Mechanical Signals Promote Proliferation In A Cell-Specific Manner: Tailoring A Non-Drug Strategy To Enhance Biomanufacturing Yields, M Ete Chan, Christopher Ashdown, Lia Strait, Sishir Pasumarthy, Abdullah Hassan, Steven Crimarco, Chanpreet Singh, Vihitaben S Patel, Gabriel Pagnotti, Omor Khan, Gunes Uzer, Clinton T Rubin
Faculty, Staff and Student Publications
Biomanufacturing relies on living cells to produce biotechnology-based therapeutics, tissue engineering constructs, vaccines, and a vast range of agricultural and industrial products. With the escalating demand for these bio-based products, any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the discipline. While these goals are primarily achieved using biological or chemical strategies, harnessing cell mechanosensitivity represents a promising - albeit less studied - physical pathway to promote bioprocessing endpoints, yet identifying which mechanical parameters influence cell activities has remained elusive. We tested the hypothesis that mechanical signals, delivered non-invasively …
Constructing Phylogenetic Trees For Microbiome Data Analysis: A Mini-Review, Ruitao Liu, Xi Qiao, Yushu Shi, Christine B Peterson, William S Bush, Fabio Cominelli, Ming Wang, Liangliang Zhang
Constructing Phylogenetic Trees For Microbiome Data Analysis: A Mini-Review, Ruitao Liu, Xi Qiao, Yushu Shi, Christine B Peterson, William S Bush, Fabio Cominelli, Ming Wang, Liangliang Zhang
Faculty, Staff and Student Publications
As next-generation sequencing technologies advance rapidly and the cost of metagenomic sequencing continues to decrease, researchers now face an unprecedented volume of microbiome data. This surge has stimulated the development of scalable microbiome data analysis methods and necessitated the incorporation of phylogenetic information into microbiome analysis for improved accuracy. Tools for constructing phylogenetic trees from 16S rRNA sequencing data are well-established, as the highly conserved regions of the 16S gene are limited, simplifying the identification of marker genes. In contrast, metagenomic and whole genome shotgun (WGS) sequencing involve sequencing from random fragments of the entire gene, making identification of consistent …
Healthcare Disparities, Screening, And Molecular Testing In The Changing Landscape Of Non-Small Cell Lung Cancer In The United States: A Review, Razelle Kurzrock, Aadel A Chaudhuri, David Feller-Kopman, Narjust Florez, Jed Gorden, Ignacio I Wistuba
Healthcare Disparities, Screening, And Molecular Testing In The Changing Landscape Of Non-Small Cell Lung Cancer In The United States: A Review, Razelle Kurzrock, Aadel A Chaudhuri, David Feller-Kopman, Narjust Florez, Jed Gorden, Ignacio I Wistuba
Faculty, Staff and Student Publications
Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describes healthcare disparities in the changing landscape of non-small cell lung cancer (NSCLC) in the United States, focusing on racial, ethnic, sex-based, and socioeconomic trends. Furthermore, strategies to address disparities, overcome challenges, and improve patient outcomes are proposed. Barriers exist across lung cancer screening, diagnosis, and treatment regimens, varying by sex, age, race and ethnicity, geography, and socioeconomic status. Incidence and mortality rates of lung cancer are higher among Black men than White men, and incidences in young women are substantially greater than …
Artificial Intelligence Uncertainty Quantification In Radiotherapy Applications – A Scoping Review, Kareem A Wahid, Zaphanlene Y Kaffey, David P Farris, Laia Humbert-Vidan, Amy C Moreno, Mathis Rasmussen, Jintao Ren, Mohamed A Naser, Tucker J Netherton, Stine Korreman, Guha Balakrishnan, Clifton D Fuller, David Fuentes, Michael J Dohopolski
Artificial Intelligence Uncertainty Quantification In Radiotherapy Applications – A Scoping Review, Kareem A Wahid, Zaphanlene Y Kaffey, David P Farris, Laia Humbert-Vidan, Amy C Moreno, Mathis Rasmussen, Jintao Ren, Mohamed A Naser, Tucker J Netherton, Stine Korreman, Guha Balakrishnan, Clifton D Fuller, David Fuentes, Michael J Dohopolski
Faculty, Staff and Student Publications
Background/purpose: The use of artificial intelligence (AI) in radiotherapy (RT) is expanding rapidly. However, there exists a notable lack of clinician trust in AI models, underscoring the need for effective uncertainty quantification (UQ) methods. The purpose of this study was to scope existing literature related to UQ in RT, identify areas of improvement, and determine future directions.
Methods: We followed the PRISMA-ScR scoping review reporting guidelines. We utilized the population (human cancer patients), concept (utilization of AI UQ), context (radiotherapy applications) framework to structure our search and screening process. We conducted a systematic search spanning seven databases, supplemented by manual …
Student Misbehaviors, University Instructors’’ Mental Health, And Trauma Management: A Phenomenological Study, Abdul Karim, Bineeta Rahman, Muhammad Kamarul Kabilan
Student Misbehaviors, University Instructors’’ Mental Health, And Trauma Management: A Phenomenological Study, Abdul Karim, Bineeta Rahman, Muhammad Kamarul Kabilan
The Qualitative Report
The present study aimed to unpack student misbehaviors that instructors face inside the university campus. It also intended to unfold how student misbehaviors affect instructors’ mental health and how they overcome the trauma engendered by student misbehaviors. Adopting a phenomenological approach, we explored the phenomenon to answer the research questions by conducting semi-structured interviews with six teachers. Through a thematic analysis, we found that university instructors experience various misbehaviors presented by students inside the university campus, and as a result, their mental health suffers. However, instructors tend to ignore their mental health and focus on academic activities to overcome the …
Cyclic Thermal Stability Of Native Oxide Solar Thermal Absorbers On Femnnialcr High Entropy Alloys For Energy Applications, Xiaoxue Gao
Dartmouth College Ph.D Dissertations
High entropy alloys (HEAs) are promising candidates for cost-effective high-temperature materials in high-efficiency power cycles. A potential application is in concentrated solar power (CSP) systems, where native oxides of cost-effective FeMnNiAlCr HEAs can also synergistically serve as a high-efficiency solar thermal absorber. However, the huge and repetitive temperature change of the CSP system in day-night cycles greatly challenges its thermal stability. In this thesis, we investigated the cyclic oxidation behavior of FeMnNiAlCr HEAs to improve the optical performance and thermal stability of their native oxides as a solar absorber for next-generation CSP systems. We found that the duplex oxide scale …