Digital Commons Network^™

Continuous Vital Sign Monitoring On Surgical Wards: The Cosmos Pilot, Nikola Anusic, Alper Gulluoglu, Elyad Ekrami, Edward J Mascha, Shuyi Li, René Coffeng, Alparslan Turan, Amber Clemens, Christine Perez, John W Beard, Daniel I Sessler

Faculty, Staff and Student Publications

Study objectives: Alerts for vital sign abnormalities seek to identify meaningful patient instability while limiting alarm fatigue. Optimal vital sign alarm settings for postoperative patients remain unknown, as is whether alerts lead to effective clinical responses reducing vital sign disturbances. We conducted a 2-phase pilot study to identify thresholds and delays and test the hypothesis that alerts from continuous monitoring reduce the duration of vital sign abnormalities.

Design: Two-phase pilot.

Patients: 250 adults having major non-cardiac surgery.

Setting: Surgical wards.

Intervention: All patients had routine vital sign monitoring by nurses at 4-h intervals. We initially continuously recorded clinician-blinded saturation, heart …

Prediagnostic Amino Acid Metabolites And Risk Of Gout, Accounting For Serum Urate: Prospective Cohort Study And Mendelian Randomization, Natalie Mccormick, Amit D Joshi, Chio Yokose, Bing Yu, Adrienne Tin, Robert Terkeltaub, Tony R Merriman, Oana Zeleznik, A Heather Eliassen, Gary C Curhan, Hang-Korng Ea, Matthew Nayor, Laura M Raffield, Hyon K Choi

Faculty, Staff and Student Publications

Objective: Our objective was to prospectively investigate prediagnostic population-based metabolome for risk of hospitalized gout (ie, most accurate, severe, and costly cases), accounting for serum urate.

Methods: We conducted prediagnostic metabolome-wide analyses among 249,677 UK Biobank participants with nuclear magnetic resonance metabolomic profiling (N = 168 metabolites, including eight amino acids) from baseline blood samples (2006-2010) without a history of gout. We calculated multivariable hazard ratios (HRs) for hospitalized incident gout, before and after adjusting for serum urate levels; we included patients with nonhospitalized incident gout in a sensitivity analysis. Potential causal effects were evaluated with two-sample Mendelian randomization.

Results: …

Silent Suffering: Demanding Individual Accountability For Sexual Assault Against Disabled Children In School Environments, Stephanie Flores

Journal of Law and Policy

Disabled children are among the most vulnerable in society, particularly in school environments where they depend on the actions and care of others for their safety. These children face significantly higher risks of sexual abuse than their non-disabled peers, and school officials' negligence can exacerbate this danger. Despite the prevalence of such cases, the Fifth Circuit's refusal to recognize school officials’ liability under the state-created danger doctrine, as seen in Fisher v. Moore, deprives disabled children of adequate legal recourse under 42 U.S.C. § 1983. The decision holds that school officials cannot be held personally liable for the peer-inflicted sexual …

The Role Of Lifr Signaling In Innate Immunity, Laura Kahn Serrudo

Dissertations and Theses (Open Access)

The localized signals that bone marrow (BM) hematopoietic stem cells (HSCs) and immune cells receive are critical in regulating their responses in the steady state and inflammation. Monocytes are an abundant and key population in the innate immune response that originates in the BM, and they circulate to monitor the periphery. Monocytes are composed of many subsets that have essential and specific functions, including swift egress from the BM, production of pro-inflammatory cytokines, and differentiation into monocyte-derived dendritic cells (MoDCs), which are required for efficient pathogen eradication.

Here, we uncovered LIFR (leukemia inhibitory factor receptor) restrains low-grade chronic inflammation in …

A Pan-Cancer Single-Cell Analysis Of Intratumoral Copy Number Diversity And Evolution, Hanghui Ye

Dissertations and Theses (Open Access)

Aneuploidy is a hallmark of human cancers, with many copy number aberrations (CNAs) being associated with disease progression. Previous studies have revealed extensive inter-patient heterogeneity (IPH) in copy number profiles. However, the extent of intratumoral heterogeneity (ITH) and its evolutionary dynamics remain poorly understood.

To address these gaps, we developed Acoustic Cell Tagmentation (ACT), an advanced single-cell single-molecule DNA sequencing (scDNA-seq) technology, to resolve the copy number substructure of human tumors and investigate the evolution of aneuploidy. Applying ACT to eight triple-negative breast cancer (TNBC) patients to profile 9,765 aneuploid tumor cells, we discovered that following initial punctuated copy number …

Oncolytic Viruses Enhance Long-Term Nk Cell Anti-Tumor Cytotoxicity Through Ap-1 And Irf Pathway Activation, Xin Ru Jiang

Dissertations and Theses (Open Access)

Natural killer (NK) cell therapeutics have emerged as a promising strategy in adoptive cellular therapy. While genetic modifications of NK cells can enhance their antitumor activity, modulating the tumor to augment NK cell recognition and function remains underexplored. In this study, we investigated the combination of NK cells with oncolytic viruses to treat solid tumors, specifically pancreatic ductal adenocarcinoma and glioblastoma. We demonstrated that infecting tumor cells with the oncolytic adenovirus Delta-24-RGD significantly increases their susceptibility to NK cell cytotoxicity, driven by a hyperactivated NK cell phenotype characterized by elevated expression of activating receptors and cytotoxicity markers. In a patient-derived …

Investigating The Rare Aneuploid Cells In Normal Breast And Therapeutic Resistance In Triple Negative Breast Cancer Using Single Cell Genomics, Yiyun Lin

Dissertations and Theses (Open Access)

Aneuploid epithelial cells are common in breast cancer, however their presence in normal breast tissues is not well understood. To address this question, we applied single cell DNA sequencing to profile copy number alterations (CNAs) in 83,206 epithelial cells from breast tissues of 49 healthy women and single cell DNA&ATAC co-assays to 19 women. Our data shows that all women harbored rare aneuploid epithelial cells (median 3.19%) that increased with age. Many aneuploid epithelial cells (median 82.22%) in normal breast tissues underwent clonal expansions and harbored CNAs reminiscent of invasive breast cancers (gains of 1q, losses of 10q, 16q and …

Associations Between Metabolic Disorders And Sjögren’S Disease, Chihiro Iwaya, Junichi Iwata

Faculty, Staff and Student Publications

Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.

Whole-Of-School Physical Activity Promotion: Findings From Elementary Schools In The United States, Derek W Craig, Christopher D Pfledderer, Natalia I Heredia, Kevin Lanza, Kempson Onadeko, Andjelka Pavlovic, Jizyah Injil, Laura F Defina, Timothy J Walker

Faculty, Staff and Student Publications

INTRODUCTION: Schools can support students' participation in physical activity by offering opportunities consistent with a Whole-of-School (WOS) approach; however, the extent to which physical activity opportunities are provided and how school-level characteristics associate with their use remains unclear. This study examined how elementary schools' use a WOS approach to promote physical activity, as well as associations between school-level characteristics and physical activity opportunities provided.

METHODS: Survey data was collected from 162 elementary schools participating in the NFL PLAY 60 FitnessGram Project during the 2022-2023 school year. A WOS index (ranging from 0 to 12) was created from responses by school …

Economic Disadvantage During Childhood, Obesity, And Diabetes Across Three Birth Cohorts Of Older Mexicans, Jesús-Daniel Zazueta-Borboa, Rafael Samper-Ternent, Rebeca Wong, Neil Mehta

Faculty, Staff and Student Publications

OBJECTIVES: Diabetes prevalence has increased markedly in Mexico. We examined the individual and joint contributions of economic disadvantage during childhood (EDDC) and elevated body weight on diabetes prevalence in 3 cohorts of Mexican adults.

METHODS: Data on those 60-69 years old from the 1930-1939, 1940-1949, and 1950-1959 birth cohorts in Waves 1 (2001), 3 (2012), and 5 (2018) of the Mexican Health and Aging Study were used. EDDC was defined as the absence of a toilet in the household before age 10. Body mass status was defined using self-reported perceived body image at age 50. Diabetes was based on respondent …

Hpv Vaccine-Related Articles Shared On Facebook From 2019 To 2021: Did Covid Make A Difference?, L Aubree Shay, Ashley Mckenzie, Elaine Avshman, Lara S Savas, Ross Shegog

Faculty, Staff and Student Publications

OBJECTIVE: HPV vaccination is recommended for children beginning at age 9 to prevent several types of cancer. Many parents turn to Facebook for health information. This study describes changes in HPV vaccine-related articles shared on Facebook amidst the COVID-19 pandemic.

METHODS: HPV-related articles shared on Facebook (2019-2021) were collected using Buzzsumo, a social media analytics tool and analyzed using content analysis. Articles were categorized by valence, misinformation, evidence types, persuasive tactics, and framing. We quantified these data and tested for difference by article year.

RESULTS: Of the 138 included articles, 51% had positive valence towards the vaccine and 36% had …

Smooth Muscle Cell Stress Response: Essential In Atherosclerotic Pathogenesis, Pujun Guan

Dissertations and Theses (Open Access)

Atherosclerosis remains the leading cause of death worldwide. Recent research using lineage tracing and single-cell RNA sequencing unveiled a previously undescribed and prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously increased expression of markers for macrophages, fibroblasts, chondrocytes, and mesenchymal stem cells as plaques form. Cultured SMCs exposed to exogenous cholesterol mimic many of the phenotypic changes associated with plaque formation, and our lab determined this SMC modulation is driven by cholesterol entering the endoplasmic reticulum (ER) and triggering ER stress and PERK signaling. Further, …

The Unconscious At Work: A Psychosocial Study Of Leaders' Unconscious Processes Impacting Participatory Change Leadership, Vanessa Hills

Dissertations

This dissertation explores the varied dynamics impacting how organizational leaders conceptualize and enact their roles in participatory change processes. To that end, a multiple-case study informed by a psycho-social approach and using Free Association Narrative Interview (FANI) methods was conducted. Each case was comprised of a single business leader. The findings, presented through individual case analyses and cross-case comparisons, reveal a discrepancy between leaders’ rhetoric and the reality of their change leadership behaviors. While leaders express support for collaborative change, factors such as a desire for control, fear of failure, and bias toward their own capabilities lead them to adopt …

Analysis Of School Lunches- A Systemic Approach, Maggie E. Eguko

Undergraduate Honors Capstone Projects

1.1. This capstone explores the persistent issue of food waste in public school lunch programs and the critical role that grant writers can play in addressing this challenge. School food waste has become a significant concern, with studies indicating that up to 50% of food served in school cafeterias is discarded, contributing to both environmental harm and inefficient resource use (Schwartz & Cohen, 2015).

1.2. The paper highlights the lack of effective waste reduction strategies, and the underutilization of available funding sources aimed at combating this issue. Grant writers, who are often underrepresented in school districts, can secure vital funding …

2023 Carroll County Advisory Council Minutes And Agendas, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

El Leñador, December 2024, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #66 December 2024

Gamma Sigma Delta, Nebraska Chapter: Newsletters

Nominations Solicitations Issue

President's Message, John R. Ruberson

Members

Grad Student Award

Teaching Award

Research Award

Extension Award

Award of Merit

Annual Membership Info

Student Award Fund

In Memoriam: John L. Lambert (April 25, 1942-July 3, 2024), Larry Elmer Germer (April 24, 1941-October 25, 2024), Leo Lucas (1931-November 13, 2024)

Pledge

United States Environmental Protection Agency Response To The Ofiice Of Science And Technology Policy Memo, 2022: Public Access Plan (December 2024)

Copyright, Fair Use, Scholarly Communication, etc.

EPA response to OSTP memo, 2022: Public Access Plan (December 2024)

United States Department Of Defense Response To The Office Of Science And Technology Policy Memo, 2022: Public Access Plan (December 2024)

Copyright, Fair Use, Scholarly Communication, etc.

DOD response to OSTP memo, 2022: Public Access Plan (December 2024)

Acf Response To Ostp Memo, 2022: Public Access Plan (December 2024)

Copyright, Fair Use, Scholarly Communication, etc.

ACF response to OSTP memo, 2022: Public Access Plan (December 2024)

Deportation Effects On Children: Rural Latina Single-Parent Families With Children In Lower Grade School Who Suffer From An Adjustment Disorder With Anxiety, Amber Millard

Student Projects

Single-parent families, especially those headed by Latina mothers, face stressors that harm both parents and their children. This is especially true for those who have been negatively affected by deportation. Deportation is a frequently overlooked cause for single-parent households. Roughly 5.7 million children live with parents who do not obtain legal residency documentation, and approximately 500,000 children had at least one parent detained or deported within the last 2 years (Rayburn et al., 2021). Due to the deportation of parents, some of these children develop anxiety-related adjustment disorders. Research into effective methods for aiding these families is limited. However, experiential …

The Life And Discoveries Of Yellapragada Subbarow, Nikhil R, Varuni Pragya, Subramanian Ramaswamy, Shiva Prasad B N, Mahabaleshwar Mamadapur

Digital Journal of Clinical Medicine

Dr. Yellapragada Subbarow was a researcher, teacher, and a wizard of wonder drugs who constantly made efforts in the discoveries/ inventions such as vitamins, anti-vitamins, antibiotics, and many more by disentangling the mysteries of nature for the betterment of the people. He inspired the youngsters to take up the challenges and to stand up above mediocrity. The reward for his achievement was delayed. The article describes a true humanist's journey, discoveries, and his achievements that are largely unknown to date.

Toxic Medicines Exhibit, Kelsey Koym

TMC Library Newsletter (2015-)

The medicines used for the Toxic Medicines and Toxic Books exhibit were selected based on their historical use to treat various ailments and diseases; however, these treatments are now known today to be quite harmful to human health. It is important to remember that the ideology around how the body works and how to treat disease has greatly changed over the last several centuries.

Also, check the McGovern Historical Collection Blog story written by Kelsey L. Koym, Archivist and Special Collections Librarian.

Understanding Global Street Food Consumer Behavior And Experience: A Narrative Review Of Literature And Development Of Framework, Samit Chakravorti

Journal of Applied Marketing Theory

This paper explores global street food consumer behavior and consumption experience. The aim of this paper is to gain a holistic comprehension of street food consumption decision making and experience through exploring nature and sources of perceptions, attitude and expectations surrounding street food, the characteristics of the product offering and the domain within which it is served and consumed. To achieve this aim the author engages in a narrative review of academic research on consumer behavior of street food, provides a holistic picture of consumption experience of street food through consolidating and interpreting research findings, and extends the theoretical understanding …

Measuring Social Influence In Online Social Networks - Focused Literature Review On Human Behaviors, Shyamala N. Chalakudi, Gnana Bharathy, Dildar Hussain, Dakshinamurthy Kolluru

Journal of Applied Marketing Theory

Measuring an individual's social influence (SI) capability is gaining traction with the rapid growth and expansive reach of online social networks (OSN). However, most existing frameworks and methods are confined to graphical theories or the structural properties of these networks. Even behavioral investigations are often limited to a narrow set of influencing behaviors and confront significant challenges in encompassing the breadth of human psychological characteristics. This study aims to address this gap through an exhaustive and focused literature review, concentrating on the definitions of human behavior characteristics rooted in established sociology and psychology theories. Beyond providing a comprehensive overview, the …

Implementation Of A New Graduate Registered Nurse Mentorship Program: A Quality Improvement Project, Cindy N. Ruisi

Nursing Doctoral

Transitioning from student to a registered nurse is a critical period for new graduates, often marked by challenges affecting confidence and job satisfaction. Mentorship programs have been identified as an effective intervention to support new nurses during this transition. The Academy of Medical-Surgical Nurses (AMSN) offers a structured mentoring program that can be leveraged to enhance the confidence level and job satisfaction of new graduate registered nurses.

This quality improvement project aims to implement a new graduate registered nurse mentorship program at a > 400-bed community hospital. This program will incorporate components of the established Academy of Medical-Surgical Nurses mentoring program, …

Law And Equity On Appeal, Aaron-Andrew P. Bruhl

Faculty Publications

Most lawyers know that the Federal Rules of Civil Procedure merged the divergent trial procedures of the common law and of equity, but fewer are familiar with the development of federal appellate procedure. Here too there is a story of the merger of two distinct systems. At common law, a reviewing court examined the record for errors of law after the final trial judgment. In the equity tradition, an appeal was a rehearing of the law and the facts that aimed at achieving justice and did not need to await a final judgment. Unlike the story of federal trial procedure, …

Elevation And Population Size Effects On The Survival Of Drosera Rotundifolia, Jessica Williams

Electronic Theses and Dissertations

Carnivorous plants face significant conservation challenges due to habitat destruction, climate change, and illegal harvesting. This study explores how elevation and population size influence key-life history traits of D. rotundifolia, such as flowering phenology, prey capture efficiency, seed production, and germination rates. Higher elevations and larger populations are associated with extended flowering durations and increased prey capture. However, seed production and germination rates show complex patterns that are likely influenced by genetic diversity, resource availability, or environmental conditions. These insights inform targeted conservation strategies, emphasizing habitat preservation, enhancing prey availability, and maintaining genetic diversity. Public education and community engagement …

Does Self-Care Moderate The Association Between Adverse Childhood Experiences, Trauma Symptoms, And Parental Reflective Functioning?, Vinaya Thomas

Electronic Theses and Dissertations

Unresolved adverse and traumatic experiences in parents can amplify the risk of perpetuating intergenerational transmission of trauma. Parents’ positive and adaptive practices such as self-care might act as a protective factor against this ripple effect. This study investigated whether self-care moderated the relationship between parental ACEs, post-traumatic stress symptoms, and parental reflective functioning in mothers who are experiencing high psychosocial stress (n = 59) residing in rural Appalachia. Within our sample, there was no statistically significant linear relationship between our predictors, ACE score and PTSD symptoms, and our outcome of interest, maternal pre-mentalizing. We did not find empirical support for …

An Exploration Of The Intersections Of The Science Of Reading And Culturally Sustaining Pedagogies: A Constructivist Grounded Theory Study Of Preservice Teachers’ Practice With Teaching Reading Comprehension, Elizabeth Kittleman

Theses and Dissertations

This study explores the possibilities and tensions that emerged when preservice teachers integrated both the science of reading and a culturally sustaining framework when learning about and teaching reading comprehension. Utilizing a constructivist grounded theory methodology, this research draws on data from interviews, student coursework samples, and a researcher journal collected over the course of a semester. During data analysis, four emergent themes were constructed: managing the multiple realities of teaching reading, leveraging background knowledge, navigating biculturalism and inequities, and negotiating a teacher’s role. Findings illustrate the complex relationship between theory and practice when preservice teachers draw on students’ linguistic …