Digital Commons Network^™

Low-Cost Vehicle Controller Testing System, Kevin R. Jung

Electrical Engineering

This project aims to create a system to facilitate easier evaluation of PCBs designed for low-voltage vehicle applications with an emphasis on accessibility for student teams in collegiate design series' such as Formula SAE. Student teams or smaller vehicle electronics manufacturers often need to verify designs and validate functionality during both development and manufacturing. An inexpensive, small, and portable, yet capable, system for taking measurements and simulating inputs would allow designers to put their boards into vehicle-representative conditions and environments without needing to connect to actual vehicle hardware. Additionally, while systems exist off-the-shelf that could fulfill the requirements needed by …

The Price Of Precision: Significant Figures And The Student Experience, Ryan Michael Britt

Dissertations

For students pursuing careers in medicine and science, general chemistry is often viewed as a gatekeeper course. Students struggle with general chemistry for a variety of reasons, one of the most common being mathematical difficulties. Compared to other lower division STEM courses, mathematical computation in general chemistry represents a unique challenge for the student due to the special emphasis placed on reporting answers to the proper degree of precision using significant figure (SF) rules. Although these rules feature in nearly every undergraduate chemistry course, their impact on the student experience of learning chemistry has never before been studied.

The purpose …

Racially And Culturally Conscious Parent Engagement Programs: Parent Contributions To A Critical Analysis, Veronica Maria Lucero

Dissertations

To capture the perspectives of Latinx families as they relate to racially and culturally conscious parent engagement programming, this qualitative phenomenological case study sought to examine the parent engagement for Latinx families and answer following research questions:

• Q1 What are the perceptions regarding parental engagement of Latinx parents who participate in parent engagement programs in a Rocky Mountain, suburban elementary school committed to considering race and culture in their engagement practices?
• Q2 How do Latinx parents perceive culturally and racially conscious parent engagement program participation impacts their students’ school experience?

In the qualitative tradition, interviews were used to critically analyze …

Evaluation Of Joint Model Imputation Of Multilevel Models, Gabriel Owusu

Dissertations

Missing data is a pervasive challenge in research, particularly in studies involving multilevel models. When left unaddressed or handled poorly, missing data can reduce statistical power and introduce bias, undermining the validity of findings. Although multiple imputation has emerged as a preferred method for addressing missing data due to its ability to provide unbiased and efficient estimates, its application in multilevel modeling remains underexplored. This gap is particularly significant given the hierarchical nature of multilevel data, which requires specialized approaches to imputation. The purpose of the study is to evaluate the effectiveness of joint model imputation in handling missing data …

Responding To The Workforce Crisis: Consensus Recommendations From The Second Workforce Summit Of The American Society Of Pediatric Nephrology., Danielle E. Soranno, Sandra Amaral, Isa Ashoor, Meredith A. Atkinson, Gina-Marie Barletta, Michael C. Braun, Joann Carlson, Caitlin Carter, Annabelle Chua, Vikas R. Dharnidharka, Keri Drake, Elif Erkan, Dan Feig, Stuart L. Goldstein, David Hains, Lyndsay A. Harshman, Elizabeth Ingulli, Alexander J. Kula, Mary Leonard, Sudha Mannemuddhu, Shina Menon, Zubin J. Modi, Marva Moxey-Mims, Arwa Nada, Victoria Norwood, Michelle C. Starr, Priya S. Verghese, Darcy K. Weidemann, Adam Weinstein, Jodi Smith

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Pediatric patients with complex medical problems benefit from pediatric sub-specialty care; however, a significant proportion of children live greater than 80 mi. away from pediatric sub-specialty care.

OBJECTIVE: To identify current knowledge gaps and outline concrete next steps to make progress on issues that have persistently challenged the pediatric nephrology workforce.

EVIDENCE REVIEW: Workforce Summit 2.0 employed the round table format and methodology for consensus building using adapted Delphi principles. Content domains were identified via input from the ASPN Workforce Committee, the ASPN's 2023 Strategic Plan survey, the ASPN's Pediatric Nephrology Division Directors survey, and ongoing feedback from ASPN …

Hypoalbuminemia In Children With Acute Lymphoblastic Leukemia: Relation To Asparaginase Therapy And Impact On High Dose Methotrexate Elimination., Sophie Rex Christensen, Christina Friis Jensen, Jesper Heldrup, Zachary Taylor, Laura Ramsey, Steen Rosthøj

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: High-dose methotrexate (HDMTX) therapy is an important component in treatment regimens for acute lymphoblastic leukemia (ALL). Courses are associated with a risk of renal injury, delayed elimination, and increased systemic toxicity. Recently hypoalbuminemia has been recognized as yet another risk factor.

METHODS: To examine the impact of serum albumin we reviewed 325 HDMTX 5 g/m2 courses in a cohort of 51 children treated on the NOPHO ALL 2008 protocol, dividing the courses into four groups with different levels of baseline albumin (A < 25 g/L, B 25-29 g/L, C 30-34 g/L and D ≥ 35 g/L).

RESULTS: Hypoalbuminemia was present in 51% of the courses, mostly in the early phases of chemotherapy while …

Decreasing Endomyocardial Biopsy Frequency In Pediatric Heart Transplantation Using A Rejection Risk Prediction Score-A Single Center Study., Drishti Tolani, Ryan J. Butts, David Sutcliffe, Alyssa Power

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Rejection remains an important cause of morbidity and mortality after pediatric heart transplantation (HT). Endomyocardial biopsy (EMB) is the gold standard for rejection diagnosis, but it comes with procedural risk. The frequency of EMB varies significantly across centers. Since April 2018, our center's surveillance EMB schedule is based on a rejection risk prediction score employing age, pre-HT diagnosis, and panel reactive antibodies (PRA). We aimed to evaluate outcomes in the 1st year post-HT before and after risk score implementation.

METHODS: Patients who underwent HT at our center at ≤ 18 years of age from January 2015 to December 2020 …

Patient Engagement In Evidence-Based Practice Frameworks., Jarrod Dusin, Jill Peltzer

Manuscripts, Articles, Book Chapters and Other Papers

Evidence-based practice (EBP) is the cornerstone of contemporary healthcare, promoting the integration of scientific evidence, clinical expertise, and patient values to inform clinical decision-making and enhance patient outcomes. While patient engagement is recognized as a critical component of EBP, the extent to which it is incorporated in various EBP frameworks is unclear. This study is a secondary analysis of a scoping review which evaluated EBP frameworks used in healthcare settings. In the current study, our objective was to assess the level of patient engagement within those frameworks. To achieve this, we employed a patient engagement framework which characterizes engagement as …

A Comparison Of The 2022 Versus 2011 National Institute Of Child Health And Human Development Web-Based Risk Estimator For Bronchopulmonary Dysplasia., Mitch Kinkor, Jake Schneider, Farhath Sulthana, Janelle R. Noel-Macdonnell Phd, Alain Cuna

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To compare the predictive accuracy of the 2022 vs 2011 National Institute of Child Health and Human Development estimator for identifying infants at high risk for bronchopulmonary dysplasia (BPD).

METHODS: We conducted a single-center retrospective study of infants ≤28 weeks' gestation. Demographic and respiratory support data were used to calculate risk for BPD or death by the BPD estimators. Our outcomes of interest included (1) treatment with systemic steroids for BPD and (2) composite outcome of death or highest severity of BPD at 36 weeks' postmenstrual age. We used c-statistics and area under receiver operator characteristic curves (AUC) to …

Azacitidine As Epigenetic Priming For Chemotherapy Is Safe And Well-Tolerated In Infants With Newly Diagnosed Kmt2a-Rearranged Acute Lymphoblastic Leukemia: Children's Oncology Group Trial Aall15p1, Erin M. Guest, John A Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown

Manuscripts, Articles, Book Chapters and Other Papers

Infants less than 1 year old diagnosed with KMT2A-rearranged (KMT2A-r) acute lymphoblastic leukemia (ALL) are at high risk of failure to achieve remission, relapse, and death due to leukemia, despite intensive therapies. Infant KMT2A-r ALL blasts are characterized by DNA hypermethylation. Epigenetic priming with DNA methyltransferase inhibitors increases the cytotoxicity of chemotherapy in preclinical studies. The Children's Oncology Group trial AALL15P1 tested the safety and tolerability of 5 days of azacitidine treatment immediately prior to the start of chemotherapy on day 6, in four post-induction chemotherapy courses for infants with newly diagnosed KMT2A-r ALL. The treatment was well-tolerated, with only …

Metaverse-Powered Basic Sciences Medical Education: Bridging The Gaps For Lower Middle-Income Countries., Syeda Samnita Batool Zaidi, Umer Adnan, Kadriye O. Lewis, Syeda Sadia Fatima

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Traditional medical education often lacks contextual experience, hindering students' ability to effectively apply theoretical knowledge in real-world scenarios. The integration of the metaverse into medical education holds great enormous promise for addressing educational disparities, particularly in lower-middle-income countries (LMICs) accompanied by rapid technological advancements. This commentary paper aimed to address the potential of the metaverse in enhancing basic sciences education within the constraints faced by universities in LMICs. We also addressed learning design challenges by proposing fundamental design elements and a suggested conceptual framework for developing metaverse-based teaching methods.The goal is to assist educators and medical practitioners in comprehensivley …

The Norwood With Blalock-Taussig-Thomas Shunt—Worth A Second Look?, Manasa Gadiraju, Dhaval Chauhan, Alexandra Schray, James O'Brien, Edo Bedzra

Manuscripts, Articles, Book Chapters and Other Papers

Background: Shunt repair for the Norwood procedure with either the right ventricle to pulmonary artery shunt (RVPAS) or the modified Blalock-Taussig-Thomas Shunt (BTTS) varies by institution and surgeon preference. Shunt choice has been informed by landmark trials including the Single Ventricle Reconstruction trial and modern outcomes data may engender future complementary studies. Methods: We conducted a retrospective analysis of all patients who underwent the Norwood procedure from 2014–2022 at a single center to compare outcomes by shunt type. The primary outcome measure was freedom from death or transplant. Secondary outcome measures included hospital length of stay, complications, and unplanned interventions. …

Guidelines On Management Of Hereditary Polyposis Syndromes In Pediatric Patients: Agreement, Disagreement And Where It Matters, Taina Hudson, Claudia Phen, Isabel Rojas, Shlomi Cohen, Warren Hyer, Thomas M. Attard

Manuscripts, Articles, Book Chapters and Other Papers

Hereditary polyposis syndromes are rare but potentially devastating conditions which require multidisciplinary care from an early age. Societal guidelines, which ideally combine expert opinions and medical evidence, serve as the framework for disease diagnosis, surveillance and treatment. However, there is a significant underrepresentation of pediatric gastroenterology input in guideline formulation, and additionally, recommendations can vary significantly between societies, which can have a moderate-to-high clinical impact on patient care. This paper aims to summarize key differences in management based on societal guidelines and identify some of the factors which may contribute to divergence in care in hereditary polyposis syndromes in pediatric …

Oh, My Quad: A Clinical Commentary And Evidence-Based Framework For The Rehabilitation Of Quadriceps Size And Strength After Anterior Cruciate Ligament Reconstruction, Braidy Solie, Mitchell Carlson, Christopher Doney, Michael Kiely, Robert Laprade

Physical Therapy Faculty Research and Publications

Quadriceps weakness after anterior cruciate ligament reconstruction (ACLR) is a well-known phenomenon, with more persistent quadriceps weakness observed after ACLR with a bone-patellar tendon-bone or quadriceps tendon autograft than with a hamstring tendon autograft. Longstanding quadriceps weakness after ACLR has been associated with suboptimal postoperative outcomes and the progression of radiographic knee osteoarthritis, making the recovery of quadriceps size and strength a key component of ACLR rehabilitation. However, few articles have been written for the specific purpose of optimizing quadriceps size and strength after ACLR. Therefore, the purpose of this review article is to integrate the existing quadriceps muscle basic …

It’S So Liberating To Do The Work: Education In Archives Creates Space For People With Disabilities, Jen Hoyer, Julia Pelaez

Publications and Research

What are the barriers and possibilities archives education presents to the disabilities community? More specifically, how can archives education and teaching with primary sources provide opportunities for disabled students that they might not find in mainstream education settings? What matters when working with students with disabilities in archives, and what does it feel like to be a disabled educator in an archive? How can education in archives provide opportunities for vulnerability, connection, and liberation? Sharing a passion for the possibilities of education work in archives and special collections, Jen Hoyer and Julia Pelaez sat down for a conversation about these …

“Don’T Bring Your Feminism Here!”: The African Hair Braiding Salon As A Rhetorically Charged Space For Feminist Activism, Efe Plange

Open Access Theses & Dissertations

This project extends scholarship on Black beauty and hair care spaces in the US as rhetorically charged for various forms of activism. It specifically explores the nature of work, conversations and feminist ways of being among a group of braiders working together in an African hair braiding salon to legitimize the African hair braiding salon as a site with unique contributions to this body of work. Grounded in Feminist Geo-criticism and Conversational Rhetoric, the study seeks to make contributions that are relevant to the field of Rhetoric and more specifically the sub-field of feminist rhetorics, African and non-Western feminist rhetorics, …

Elevating Voices: Exploring The Lived Experiences Of Chicano/A Students Labeled As At-Risk Along The U.S.-Mexico Border During Their Eighth Grade Year, Ricky Ramirez

Open Access Theses & Dissertations

This study investigates the lived experiences of Chicano students who were labeled as at-risk during their time in eighth grade in a public school located along the U.S.-Mexico border. This study focuses on the academic and personal experiences of these students. Through the qualitative methodology of Narrative Inquiry, this study captures the narratives of the participants and provides insight into factors that impacted their personal and academic journeys. This study draws connections between the participants' experiences and four themes that grounded the studyâ??s comprehensive literature review: Maslowâ??s Hierarchy of Needs, Social and Emotional Learning (SEL) using the Collaborative for Academic, …

Empowering Communication Course: A Study On Reflective Appraisal By Nursing Students, Mei-Yu Yeh, Shu-Mei Wu, Yu-Lan Chen, Hui-Ling Lee, Pei-Chun Liao

Journal of Medical Education

Background: In Taiwan, patient empowerment is lacking in clinical settings, both in principle and practice. Nursing education that encourages students to enhance their self-awareness and learn how to empower patients through communication is important. Research and purpose: This study evaluated the qualitative and quantitative effects of a course on empowering communication in nursing students' reflective learning of practical nurse-patient communication skills. Methods: This study employed interactive videos filmed in hospital wards as teaching materials. Teaching strategies included video evaluation and analysis, case discussions, and roleplay exercises. Twenty-two nursing students participated in the qualitative and quantitative study, respectively. After course completion, …

A Hospital Visit Course To Immerse Medical Students In The Patient Journey, Interprofessional Collaboration, And Medical Technology, Tzu-Chan Hong, Tzu-I Chien, Hsiu-Ping Lai, Chiun Hsu

Journal of Medical Education

Problem statement: Traditional medical education often emphasizes technical skills while under-addressing non-technical competencies such as patient-centered care, interprofessional collaboration, and systems-based practice. Innovative approaches like experiential learning provide a valuable platform to bridge this gap, fostering deeper understanding, critical thinking, and actionable insights for medical students into these essential aspects of modern healthcare. Methods: The course utilized a hospital-based experiential learning infrastructure for fifth-year medical students, incorporating guided tours to teach patient-centered care, interprofessional collaboration, and the role of technology in healthcare. Data for the perceived impact of teaching were collected through reflection reports and pre- and post-class questionnaires, with …

Twelve Tips To Support Students' Wellbeing In Contemporary Health Professional Programs, Tala Maragha, Hsingchi Von Bergmann

Journal of Medical Education

Background: The education and practice of health professional education (HPE) can challenge an individual's wellbeing. Such challenges often originate during preparation programs and can persist and/or fester as students become practitioners. If left unaddressed, these challenges may impact health professionals' quality of life and the community they serve at large. Aims: This paper aims to off er strategies and practical tips for administrators, educators, and students to ensure nurturing and positive learning environments that prioritize health professionals' wellbeing. Description: A review of health professional teaching and learning theories, in addition to contemporary literature on students' wellbeing, emphasizes a continuous process …

Advocating For More Personalized And Evidence-Based Approaches In Dental Practice, Integrating Advanced Diagnostic Tools And Innovative Treatments To Enhance Patient Care, Hasanuddin, Acing H. Mude, Muhammad Ikbal, Erni Marlina, Muhammad Ruslin

Journal of Dentomaxillofacial Science

This editorial review highlights a series of studies emphasizing evident discoveries in the diagnosis and treatment of oral diseases. The first report addresses a rare case of unicystic ameloblastoma located in the maxillary sinus, highlighting the need of histological analysis for precise identification despite deceptive radiographic characteristics. A different example examines dentigerous cysts, highlighting diagnostic problems stemming from unusual appearances, finally clarified by histological assessment. The effectiveness of sclerotherapy with hypertonic saline for treating parotid sialocele is examined, indicating it as a safe and efficacious therapeutic alternative. The influence of anemia on pediatric drug-induced erythema multiforme is examined, highlighting the …

The Role Of Porphyromonas Gingivalis In Inducing Il-6 Macrophages Expression In Ovaries Of Periodontitis Models, Agustin Ws. Dharmayanti, Ernie M. Setiawatie, Hendy Hendarto

Journal of Dentomaxillofacial Science

Objective: This study aimed to determine whether P. gingivalis induction in the gingival sulcus increased IL-6 expression by macrophages in the ovaries.

Material and Methods: This research was a laboratory experiment using a post-test-only control group design, using female white rats strain Sprague Dawley, six weeks old and in the estrous phase. They were divided into the control and treatment groups. The animal models were induced with P. gingivalis in the mesial gingival sulcus of their first right and left lower jaw molars, with 0.05 ml every three days for 19 days. On 0, 7, 14 days after bacteria induction, …

Evaluation Of Calcium, Fluoride, And Phosphate Ion Release Of Three Bioactive Resins In Ph-Cycling Solution, Dewi Puspitasari, Agung S. Wardhana, Indri I. Tari, Romadhona Setiyoly, Ariska, Sherli Diana, Muhammad Yi. Nahzi, Diana Wibowo, Yosi K. Eriwati, Priyawan Rachmadi

Journal of Dentomaxillofacial Science

Bioactive resin containing calcium, fluoride, and phosphate in the formulation may promote remineralization in email and dentin. This study aimed to evaluate the amount of calcium, fluoride, and phosphate ions released from composite resin, alkasite, and giomer when stored in a pH-cycling solution. Ninety specimens (diameter 15 mm & thickness 1 mm, n=5/group) were fabricated with bioactive composite resin (Activa), alkasite (Cention N), and giomer (Beautifil II). Half of the specimens were immersed in demineralizing solution of pH 4.4 and remineralizing solution of pH 7 alternating constantly for pH-cycling. In contrast, the other half of the specimens were immersed in …

Establishment Of A Comprehensive Epa Framework For Medical Radiation Technologists In Taiwan: A Consensus-Driven Approach, Shu-Yu Wen, Yao-Ting Lu, Shin-Shyang Huang, Chun-Yuan Tu, Szu-Hsuan Yu, Cheng-Heng Liu, Chih-Wei Yang

Journal of Medical Education

Background: This study established a comprehensive Entrustable Professional Activity (EPA) framework for Medical Radiation Technologists (MRTs) in Taiwan. Since 2019, MRTs from various teaching hospitals have collaborated to define EPAs, beginning with six activities. Given the complexity of clinical responsibilities in radiology, developing consensus-driven EPAs is crucial for effective curriculum design and competency assessment. Methods: In 2023, the Taiwan Association of Medical Radiation Technologists (TAMRT) convened consensus-building meetings with experts from three radiology subspecialties. Through focus group discussions and a modified Delphi method, participants reviewed and refined proposed EPAs and task specifications. Consensus was assessed using a 5-point Likert scale, …

Exploring The Effectiveness Of Incorporating Peer Observation Of Teaching Strategies In Clinical Teacher Training For Post-Graduate Year Training, Ling-Chun Ou, Yi-Chun Tsai, Wen-Yu Ho, Yu-Shan Cheng, Yu-Chih Lin

Journal of Medical Education

Background: Taiwan's postgraduate year (PGY) training program was implemented in 2003 as a requirement before students could participate in any residency or fellowship training. A nationwide standardized clinical teacher training program was subsequently introduced to strengthen clinical teachers' ability in the context of PGY training. After several years, this standardized clinical teacher training program has begun to encounter the issue of content diversity. Clinical teachers have backgrounds in different specialties and subspecialties, and the educational context has evolved. Peer observation of teaching (POT) is an effective strategy for promoting peer learning and active self-directed learning. This study aimed to incorporate …

The Learning Crisis: Three Years After Covid-19, Tomasz Gajderowicz, Maciej Jakubowski, Alec Kennedy, Christian Christrup Kjeldsen, Harry Anthony Patrinos, Rolf Strietholt

Education Reform Faculty and Graduate Students Publications

The COVID-19 pandemic caused widespread disruptions to education, with school closures affecting over one billion children. These closures, aimed at reducing virus transmission, resulted in significant learning losses, particularly in mathematics and science. Using data from TIMSS 2023, which assesses fourth and eighth-grade achievements across 71 education systems, this study analyzes the impact of school closure duration on learning outcomes. Mixed-effect models estimate deviations from pre-pandemic trends, adjusting for demographic factors. Results show a global average decline of 0.11 standard deviations (SD) in student achievement, with longer closures linked to more severe losses. The effects on low performers, girls, and …

Time Series Decomposition Of Land Surface Temperature For Long-Term Trend Forecasting And Impact On Nesting Sea Turtle Habitats In The Arabian Gulf, Sachi Perera, Rommel H. Maneja, Mohamed Allali, Cyril Rakovski, Erik Linstead, Daniele Struppa, Ali Qasem, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Improving land surface temperature (LST) modeling is vital for mitigating climate change effects on various ecosystems and marine habitats such as important sea turtle habitats. Over the past decade, extreme temperatures have likely significantly affected nesting sea turtle habitats in the Arabian Gulf, with predominantly female hatchlings creating an imbalance in the sex ratio. Such shifts have profound implications for these habitats’ long-term survival and conservation management. This study leverages statistical machine learning models to measure ongoing temporal variations in LST. We break down the LST time series into trend, seasonal, and noise components using classical decomposition methods like X11, …

Detecting Fraudulent Medicare Claims With Imbalanced Data Classification, Akbota Aitbayeva

Mathematics Theses, Dissertations, Research and Student Creative Activity

Medicare, a public health insurance program, provides essential coverage to older adults and individuals with certain disabilities but suffers significant financial losses from fraudulent activities such as false claims and upcoding. To combat this, machine learning techniques, including XGBoost and Random Forest, were employed to detect fraudulent behavior in Medicare data provided by Mutual of Omaha. A key challenge in fraud detection is the imbalance in datasets, with legitimate claims vastly outnumbering fraudulent ones. This study addressed the issue using cost-sensitive methods and sampling techniques, including Random Oversampling, SMOTE, and Random Undersampling. A baseline model without any imbalance techniques was …

A Word From The Writing Team (December 2024), Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Publication Spotlight
• Enter the Annual Theresa and Charles Yeo Writing Prize by December 31, 2024
• Sign up for the December 6th Writing Retreat (Online)
• Write that Baby in 9 Weeks
• The OPWPC Canvas Page offers helpful tools

Adverse Childhood Experiences And Early Life Adversity And Their Effects On Chronic Health: A Literature Review, Ella Weatherford

The Eleanor Mann School of Nursing Undergraduate Honors Theses

With more than 439,000 annual U.S. deaths associated with childhood adversity, it is important to understand and prevent exposure to Adverse Childhood Events and Early Life Adversity. The purpose of this literature review is to identify and examine the pathophysiology between adverse childhood experiences (ACE’s) and their negative effects on health across the lifespan. Fifteen peer-reviewed articles that were published in notable journals were analyzed to include in this review. The results of these articles show that Adverse Childhood Experiences and Early Life Adversity can lead to the development of chronic inflammatory conditions across the lifespan. Using Barker Hypothesis and …