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2024

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Ascende Altius: Issue 4, Cynthia Haynes, Uofm Graduate School Dec 2024

Ascende Altius: Issue 4, Cynthia Haynes, Uofm Graduate School

Ascende Altius

Welcome to the UofM Graduate School newsletter Ascende Altius! The name of the UofM’s new strategic plan is Ascend. The word “ascend” means to climb, to move upward. It is fitting, then, that the Graduate School’s newsletter be named Ascende Altius! —a Latin phrase meaning “Climb higher!” With over 20 doctoral programs, 40 master’s programs, and a variety of graduate certificates, the University of Memphis graduate school can help you continue your educational journey and reach new heights. We encourage you to explore our flexible and affordable programs.

In this newsletter, you will read about our amazing alumni and students …


Identifying Anticipated Challenges When Implementing Group Care: Context-Analyses Across Seven Countries To Develop An Anticipated Challenges Framework, Astrid Van Damme, Florence Talrich, Mathilde Crone, Marlies Rijnders, Crystal L. Patil, Sharon Schindler Rising, Jedidia Abanga, Deborah Lynn Billings Phd, Ashna D. Hindori-Mohangoo, Manodj P. Hindori, Nele Martens, Shanaaz Mathews, Vlorian Molliqaj, Marsha Orgill, Wiedaad Slemming, Katrien Beeckman Dec 2024

Identifying Anticipated Challenges When Implementing Group Care: Context-Analyses Across Seven Countries To Develop An Anticipated Challenges Framework, Astrid Van Damme, Florence Talrich, Mathilde Crone, Marlies Rijnders, Crystal L. Patil, Sharon Schindler Rising, Jedidia Abanga, Deborah Lynn Billings Phd, Ashna D. Hindori-Mohangoo, Manodj P. Hindori, Nele Martens, Shanaaz Mathews, Vlorian Molliqaj, Marsha Orgill, Wiedaad Slemming, Katrien Beeckman

Publications

Problem

Despite increasing interest in Group Care worldwide, implementation is challenging.

Background

Group Care is an evidence-based perinatal care model including three core components: health assessment, interactive learning, and community building. It has several advantages for service users and providers compared to individual perinatal care.

Aim

We aimed to identify anticipated challenges when implementing Group Care, and to develop a supporting tool based on these challenges.

Methods

Context analyses through Rapid Qualitative Inquiries were conducted in 26 sites in seven countries to gain insight into the anticipated challenges when implementing Group Care. Data triangulation and investigator triangulation were applied. The …


Troubling Paradise: Exploring The Experiences Of National Student Exchange Participants To The University Of HawaiʻI At Mānoa, Allison Yap Dec 2024

Troubling Paradise: Exploring The Experiences Of National Student Exchange Participants To The University Of HawaiʻI At Mānoa, Allison Yap

Journal of Comparative & International Higher Education

No abstract provided.


Global South Sisterhood In A Virtual Exchange: A Critical Autoethnography, Bhavika Sicka, Arzu Atajanova Dec 2024

Global South Sisterhood In A Virtual Exchange: A Critical Autoethnography, Bhavika Sicka, Arzu Atajanova

Journal of Comparative & International Higher Education

No abstract provided.


From The Personal To The Professional: International Student Experiences Of Seeking Employment In The United States, Hayley Weiner, Peter G. Ghazarian Dec 2024

From The Personal To The Professional: International Student Experiences Of Seeking Employment In The United States, Hayley Weiner, Peter G. Ghazarian

Journal of Comparative & International Higher Education

No abstract provided.


An Extensive Exploration Of Generalist Microbotryum Species Through Host Interactions., Emilee Walters Dec 2024

An Extensive Exploration Of Generalist Microbotryum Species Through Host Interactions., Emilee Walters

College of Arts & Sciences Senior Theses

The Microbotryum species complex is a group of fungi, commonly known as anther smuts. Anther smuts are plant parasites that must invade a host plant in order to fulfill their life cycle. As the Microbotryum fungus grows, it sterilizes the host plant, such that infected plants produce fungal teliospores instead of pollen on the male reproductive organs and female reproductive structures do not mature. Microbotryum usually exists as a specialist species, however, there is evidence that several species of anther smuts can exist as generalist species. Comparisons of the infection process and the resulting response of both parasite and host …


Unpacking The Impact Of Mixed Messaging, Lizzie Bell Dec 2024

Unpacking The Impact Of Mixed Messaging, Lizzie Bell

All Theses

In recent years, organizations that demonstrated mixed messaging in their support for LGBTQIA+ communities following consumer backlash have been thrown into the spotlight. This study investigated the impact of organizational mixed messaging on prospective employees' perceptions using both a politically charged issue (LGBTQIA+ rights) and a neutral issue (reading campaign). Drawing from both signaling and social identity theory, it was hypothesized that organizations inconsistent in their support for LGBTQIA+ issues would be rated lower in attractiveness and integrity, with higher perceptions of hypocrisy. Additionally, a three-way interaction between organizational consistency, politicization of the organizational stance, and participant political affiliation was …


Addressing The Public Health Concern Of Maternal Mortality In Houston, Texas, Lucy Couture Dec 2024

Addressing The Public Health Concern Of Maternal Mortality In Houston, Texas, Lucy Couture

Dissertations and Theses (Open Access)

Maternal mortality remains a pressing public health concern in the United States, with disproportionate consequences for marginalized communities. Despite being a developed nation, the U.S. reports one of the highest maternal mortality rates among its peers, with approximately 80% of maternal deaths deemed preventable. Texas reflects this national crisis, particularly affecting Black women, whose maternal mortality rate is significantly higher than that of other racial and ethnic groups. This thesis explores maternal mortality trends in Houston, Texas, analyzing the roles of systemic inequities, social determinants of health, and disparities in access to quality care. Drawing on data from the Texas …


Permanence Collection, Justine Vandenberg Dec 2024

Permanence Collection, Justine Vandenberg

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Justine Vandenberg is an Environmental Fellow student at DePauw University majoring in Sustainability Science and Environmental Studies. She is also a writer, poet, and photographer who is passionate about using artistic forms to advocate for the health of ecosystems and human communities. She finds beauty in hiking, gardening, and mountain life.


Editorial – Dec 2024, Edwin Van Teijlingen, Abeer Musaddique, Rafat Jan Dec 2024

Editorial – Dec 2024, Edwin Van Teijlingen, Abeer Musaddique, Rafat Jan

Journal of Asian Midwives (JAM)

No abstract provided.


Enhancing Respiratory Health With Post-Yoga Exercises During Pregnancy, Hiromi Ito-Kaneko, Masayuki Uehara Dec 2024

Enhancing Respiratory Health With Post-Yoga Exercises During Pregnancy, Hiromi Ito-Kaneko, Masayuki Uehara

Journal of Asian Midwives (JAM)

Pregnancy results in enlarged uterus and diaphragm elevation, which may cause shallow breathing. These changes often cause nocturnal dyspnea, chest discomfort, and difficulty breathing, especially late pregnancy. Training of pregnant women for extending their exhalation reduces suffocation during movement, increasing comfort during pregnancy. In prenatal yoga, deep breathing is practiced and has a relaxing effect.
The purpose of this study is to determine whether yoga exercises during pregnancy improves exhalation length.
We enrolled 152 pregnant women and used a chronograph to measure their exhalation length pre- and post-yoga exercises and compared exhaled breath length by gestational age group. The pre-yoga …


The Role Of Midwives In Achieving The Global Sustainable Development Goals, Bakhtawar Muhammad Hanif Khowaja Bk, Elizabeth K. Darling Dec 2024

The Role Of Midwives In Achieving The Global Sustainable Development Goals, Bakhtawar Muhammad Hanif Khowaja Bk, Elizabeth K. Darling

Journal of Asian Midwives (JAM)

The sustainable development goals (SDGs) provide a comprehensive framework for global development. Midwives are playing an important role in achieving the targets of the world’s priority agendas. They are actively involved in achieving the targets of SDG#2 by providing education to women on their nutritional requirements, supporting postnatal women with breastfeeding, and educating communities on the use of clean water, sanitation, and hygiene management. Beyond counseling and educating communities on nutrition and hygiene management, they are also involved in improving other health-related outcomes that are indicators for SDG#3, such as improving maternal and child immunization, counseling mothers on tobacco …


Factors Influencing Colostrum Avoidance In Developing Countries: Insights From A Literature Review, Muhammad Zeeshan Aslam, Jonathan Johnson, Marina Baig, Abeer Musaddique Dec 2024

Factors Influencing Colostrum Avoidance In Developing Countries: Insights From A Literature Review, Muhammad Zeeshan Aslam, Jonathan Johnson, Marina Baig, Abeer Musaddique

Journal of Asian Midwives (JAM)

Introduction: Colostrum is a thick, sticky, clear and yellowish-coloured milk produced after the first few hours of birth until day 3. It consists of vitamin A, proteins, lipids, potassium, and maternal antibodies, including lactoferrin, immunoglobulin, growth factors and antimicrobial factors. Colostrum avoidance is the practice of squeezing out, pumping, and discarding the first milk. Various studies have reported colostrum avoidance worldwide, but its prevalence is higher in developing countries. Every day, approximately 3000 to 4000 infants die due to diarrhea and respiratory infections in developing countries, and one of the leading causes is colostrum avoidance. Infants are unable to take …


Compassionate Care In Times Of Loss: Unraveling Nurses’ And Midwives’ Perspectives To Assess Preparedness In Stillbirth: A Review Article, Nabila Salim Ali, Arusa Lakhani, Salma Rattani, Sidrah Nausheen Dec 2024

Compassionate Care In Times Of Loss: Unraveling Nurses’ And Midwives’ Perspectives To Assess Preparedness In Stillbirth: A Review Article, Nabila Salim Ali, Arusa Lakhani, Salma Rattani, Sidrah Nausheen

Journal of Asian Midwives (JAM)

Perinatal death, including stillbirth, is a tragic event that significantly impacts holistically the well-being of affected families, particularly in low-middle-income countries (LMICs), where the incidence is alarmingly high. This paper explores the profound effects of stillbirth on parental mental health, emphasizing the associated risks of mental health challenges and examining the crucial role of nurses and midwives in managing stillbirth, from providing immediate emotional support to facilitating long-term coping strategies. Despite their essential role, they face significant challenges, including inadequate training, emotional burdens, and the need for culturally sensitive care practices. Through a comprehensive review of the literature, this paper …


Improve The Referral System Of Health Care Organizations In Rural Community Settings Of Pakistan Using Health Information Technology (Hit) - A Protocol, Saleema A. Gulzar, Alishah Aziz Gulzar, Zahid Ali Faheem, Ayesha Arif, Aamir Sarfaraz Dec 2024

Improve The Referral System Of Health Care Organizations In Rural Community Settings Of Pakistan Using Health Information Technology (Hit) - A Protocol, Saleema A. Gulzar, Alishah Aziz Gulzar, Zahid Ali Faheem, Ayesha Arif, Aamir Sarfaraz

Journal of Asian Midwives (JAM)

Pakistan is a developing country, with 65% of the population residing in rural areas. The rural population is considered vulnerable mainly due to several factors, including poverty. Climate change and the area's topography limit their access to basic human needs such as basic healthcare, affecting their quality of life. Most people lack basic information about the location and availability of healthcare facilities, including hospitals, diagnostic centres, pharmacies, and general clinics. Hence, the rural healthcare system lacks primary care physicians, nurses, midwives and allied health professionals. Inappropriate infrastructure makes it challenging to retain qualified professionals. A non-profit and non-governmental entity aims …


Kolcaba’S Comfort Theory: A Framework For Understanding The Significance Of Skin-To-Skin Care After Childbirth, Aqsa Nizar Ali Dec 2024

Kolcaba’S Comfort Theory: A Framework For Understanding The Significance Of Skin-To-Skin Care After Childbirth, Aqsa Nizar Ali

Journal of Asian Midwives (JAM)

Despite the WHO recommendations and evidenced-based results of skin-to-skin contact, it is quite an uncommon practice witnessed after childbirth. Compared to research conducted in low and middle-income nations, the majority of the studies conducted in high-income countries revealed greater rates of SSC [11]. Skin-to-skin contact, a nurturing practice, has gained significant recognition as a cornerstone of early infant care. Beyond its physiological benefits, skin-to-skin contact fosters a profound sense of comfort and connection between mother and infant. Kolcaba's theory of comfort, a comprehensive framework for understanding and promoting comfort, provides a valuable lens to explore the multifaceted benefits of skin-to-skin …


Burden Of Vascular Neurological Disorders: A Cross-Sectional Multicenter Study, Shafaq Saleem, Safia Awan, Ibrar Rafiq, Muhammad Hassan Shaikh, Anjum Farooq, Maimoona Siddiqui, Zainab Aslam Saeed Memon, Alam Ibrahim Siddiqui Dec 2024

Burden Of Vascular Neurological Disorders: A Cross-Sectional Multicenter Study, Shafaq Saleem, Safia Awan, Ibrar Rafiq, Muhammad Hassan Shaikh, Anjum Farooq, Maimoona Siddiqui, Zainab Aslam Saeed Memon, Alam Ibrahim Siddiqui

Pakistan Journal of Neurological Sciences (PJNS)

Background and Objective

Stroke remains a leading cause of morbidity and mortality worldwide, with a particularly high burden in low- and middle-income countries (LMICs) such as Pakistan. Despite its growing prevalence, limited nationwide data exist on vascular diseases, their risk factors, and disability outcomes. The objective of this study was to identify the frequency and age-stratified type of vascular disease incidence among in-patient hospital admissions.

Methods

A retrospective observational study was conducted across 39 neurology centers in Pakistan, spanning both public and private sectors from August 2017 to December 2019. Data on demographics, comorbidities, and stroke type were systematically collected …


Electrographic Significance Of Periodic Discharges And Association With Etiology And Outcome In A Tertiary Care Hospital: A Retrospective Cohort Study, Hina Imtiaz, Zainab Memon, Ayisha Farooq Khan, Dureshahwar Kanwar, Safia Awan Dec 2024

Electrographic Significance Of Periodic Discharges And Association With Etiology And Outcome In A Tertiary Care Hospital: A Retrospective Cohort Study, Hina Imtiaz, Zainab Memon, Ayisha Farooq Khan, Dureshahwar Kanwar, Safia Awan

Pakistan Journal of Neurological Sciences (PJNS)

Background and Objective

Periodic discharges on electroencephalograms (EEGs) are rhythmic waveforms that may indicate acute or subacute brain injury. This aim of this study was to determine the frequency distribution of periodic discharge subtypes on EEG and to assess their association with underlying etiologies and clinical outcomes in a tertiary care hospital.

Methods

This retrospective observational cohort study included neurological patients aged ≥18 years admitted to the medical ICU or ward of Aga Khan University Hospital between January 1, 2021, and January 1, 2023, with periodic discharges on EEG. Patients with prior traumatic brain injury were excluded. Data on demographics, …


Epilepsy In Pakistani Adolescents Amid The Vaping Epidemic, Maheen Kalwar, Eisha Tur Raazia, Harmain Naz Shaikh Dec 2024

Epilepsy In Pakistani Adolescents Amid The Vaping Epidemic, Maheen Kalwar, Eisha Tur Raazia, Harmain Naz Shaikh

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.


New Onset Seizures Evolving Into Refractory Status Epilepticus In The Setting Of Covid-19: A Case Report, Mahira Mushtaq, Zuha Amin, Shafaq Saleem, Fowzia Siddiqui Dec 2024

New Onset Seizures Evolving Into Refractory Status Epilepticus In The Setting Of Covid-19: A Case Report, Mahira Mushtaq, Zuha Amin, Shafaq Saleem, Fowzia Siddiqui

Pakistan Journal of Neurological Sciences (PJNS)

The novel Coronavirus disease (COVID-19) has been shown to involve the nervous system (both central and peripheral), with or without respiratory involvement in multiple ways. Although not much is known about this disease yet, seizures and status epilepticus which may evolve into refractory status epilepticus have been associated with it along with other manifestations like encephalopathy, neuropathies etc. The mechanism for development of seizures with COVID-19 related disease is not entirely known however it can be the consequence of “cytokine release syndrome” or “cytokine storm” which has been associated with this virus. Patients with COVID-19 infection who develop resistant status …


Pakistan Ischemic Stroke Guidelines, Anjum Farooq, Maria Khan, Ayesha Zafar, Husnain Hashim, Fozan Khan, Abdul Malik, Ayeesha Kamran Kamal Aga Khan University, Karachi, Mohammad Wasay Dec 2024

Pakistan Ischemic Stroke Guidelines, Anjum Farooq, Maria Khan, Ayesha Zafar, Husnain Hashim, Fozan Khan, Abdul Malik, Ayeesha Kamran Kamal Aga Khan University, Karachi, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Stroke is the second leading cause of death and disability. Mortality related to stroke is very high in low- and middle-income countries. Stroke imposes a great socioeconomical burden in Pakistan. It is important to take important steps for prevention and proper management of stroke in country. Purpose of developing stroke guidelines is to improve stroke care in Pakistan. Guidelines are designed to help neurologists and general practitioners for treating stroke. American stroke guidelines, NICE guidelines, Canadian guidelines and multiple important articles including those emphasizing stroke care in low- and middle-income countries were studied, and these current guidelines were designed in …


Induced Systemic Resistance Against Nematodes By Plant Growth-Promoting Microbes In Potatoes, Cole Grannan Dec 2024

Induced Systemic Resistance Against Nematodes By Plant Growth-Promoting Microbes In Potatoes, Cole Grannan

Master's Theses

Biofertilizers consist of plant growth-promoting microorganisms that establish symbiotic relationships with plant roots and stems. These beneficial microbes play a crucial role in enhancing plant defenses against various threats including insects, nematodes, and microbial pathogens. The purpose of this study was to investigate the effectiveness of two fungal biofertilizers (an endophytic strain of Beauveria bassiana (BA) and a mixture of arbuscular mycorrhizal (AM) fungi), specifically their ability to induce systemic resistance against plant- parasitic nematodes (PPNs) in potatoes (Solanum tuberosum cv. Masquerade) under controlled greenhouse conditions. The study utilized soil collected from Colorado State University’s San Luis Valley (SLV) Research …


Social Justice In Dance: The Exploration Of Dance As A Tool For Promoting, Recognizing And Influencing Change, Michelle O'Konis Linnehan Dec 2024

Social Justice In Dance: The Exploration Of Dance As A Tool For Promoting, Recognizing And Influencing Change, Michelle O'Konis Linnehan

Master's Theses

The purpose of this study was to prove that dance could be used as a platform for representation and to foster change within the community and beyond. This purpose aligned with the goal, which was to measure the impact of a structured choreographic curriculum on student engagement with social justice topics. The goal of this study was to answer the following research questions:

Q1 Can dance be a tool in promoting social justice?

Q2 How will students in the classroom respond to an integrated social justice theme through dance and production components?

Q3 How will these topics be interpreted to …


International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li Dec 2024

International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li

Clinical Research Faculty Publications

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy with significant reproductive, metabolic, and psychological complications. Consensus on PCOS clinical research priorities across end-users is fundamental and necessitates a robust co-development of a clinical research roadmap to guide international research efforts. Methods: A multistage process included: i) international surveys of women and healthcare providers to identify research priorities and unmet needs; ii) interrogation of systematic reviews conducted for the International PCOS Guideline to identify research gaps; iii) International PCOS Guideline Network consensus generated clinical research roadmap; and iv) international peer review for external validation. Findings: A codesigned survey engaging 1278 …


Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao Dec 2024

Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

No abstract provided.


Dalbavancin Use At A Health System Network In Compliance With A Standard Plan Of Treatment For Infective Endocarditis And Osteomyelitis, Nicholas Lombardi, Anthoula Kritikos, Jacky Ye, Victor Cohen Dec 2024

Dalbavancin Use At A Health System Network In Compliance With A Standard Plan Of Treatment For Infective Endocarditis And Osteomyelitis, Nicholas Lombardi, Anthoula Kritikos, Jacky Ye, Victor Cohen

Doctoral External Publications

Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and soft tissue infections caused by gram-positive microorganisms.

Used off-label in the management of infective endocarditis in IV drug users, as well as in osteomyelitis infections.

Extremely long half-life of greater than a week.

Potential cost-effective option for susceptible gram-positive infections and increased patient compliance.


Leading Biologics In Pharmacy Practice: The Role Of Pharmacists, Amerah Elshayeb, Emily Austin, Lipika Chablani Dec 2024

Leading Biologics In Pharmacy Practice: The Role Of Pharmacists, Amerah Elshayeb, Emily Austin, Lipika Chablani

Doctoral External Publications

Evaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of biologics.


Impact Of Order Set Implementation On Institutional Management Of Clostridioides Difficile In Adult Patients, Nicole Henry, Olivia Campbell, Heather Daly, Katelyn Quartuccio, Melanie Lintala Dec 2024

Impact Of Order Set Implementation On Institutional Management Of Clostridioides Difficile In Adult Patients, Nicole Henry, Olivia Campbell, Heather Daly, Katelyn Quartuccio, Melanie Lintala

Doctoral External Publications

In February 2022, the University of Rochester Medical Center (URMC) updated their practice guidelines, in accordance with the Infectious Diseases Society of America, to include fidaxomicin as the preferred agent in patients with initial (non-fulminant) or first recurrence of C. difficile infection (CDI).

Health system protocols were updated to include polymerase chain reaction (PCR) testing for patients with suspected CDI followed by confirmation via toxin enzyme immunoassay (EIA).

In the appropriate clinical context, PCR+/EIA+ test confirms active CDI and warrants antibiotic treatment.

PCR+/EIA- test indicates likely colonization and may preclude the need for treatment.

A CDI order set was implemented …


Local Chapters Of Ashp And Apha Partner With The Monroe County Sheriff’S Department To Host A Drug Take-Back Event In The Rochester Community, Mackenzie Bermingham, Michael Currier, Bailey Walker, Laura Witt, Shawn E. Fellows, Angela Nagel Dec 2024

Local Chapters Of Ashp And Apha Partner With The Monroe County Sheriff’S Department To Host A Drug Take-Back Event In The Rochester Community, Mackenzie Bermingham, Michael Currier, Bailey Walker, Laura Witt, Shawn E. Fellows, Angela Nagel

Doctoral External Publications

Objection/Study Goals:

To provide a safe, environmentally responsible way to dispose of unused or expired medications and to raise awareness about the risks of medication misuse in the community.


Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster Dec 2024

Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster

All Dissertations

This dissertation investigates the development and optimization of pathology-responsive polymersomes for simultaneous enhanced magnetic resonance imaging (MRI) and enzyme replacement therapy (ERT) in the treatment of GM1 gangliosidosis (GM1). While therapeutic strategies exist for similar, non-neuropathic lysosomal storage disorders, implementation towards GM1 faces significant challenges due to the blood-brain barrier.

Herein, we developed and characterized a range of low molecular weight hyaluronic acid-b-polylactic acid (HA-PLA) polymersomes (PSs) capable of encapsulating therapeutic enzymes in their hydrophilic core. These polymersomes exhibit pathophysiology-triggered responsiveness, degrading in the presence of acidic conditions, which is characteristic of lysosomes, and enzymes such as hexosaminidase A, which …