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Articles 271 - 300 of 1255
Full-Text Articles in Entire DC Network
Midweek Memo, Georgia Southern University
Midweek Memo, Georgia Southern University
Midweek Memo
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Design Of A Tool Capable Of Assessing Environmental Sociocultural Physical Factors Influencing Women's Decisions On When And Where To Toilet Within Real-World Settings: Protocol For The Build And Usability Testing Of A Mobile App For Use By Community-Dwelling Women, Janis M Miller, Jean F Wyman, Lawrence An, Haitao Chu, Cynthia S Fok, Missy Lavender, Cora Elizabeth Lewis, Alayne D Markland, Leslie M Rickey, Ying Sheng, Siobhan Sutcliffe, Lisa Kane Low, Elizabeth R Mueller
Design Of A Tool Capable Of Assessing Environmental Sociocultural Physical Factors Influencing Women's Decisions On When And Where To Toilet Within Real-World Settings: Protocol For The Build And Usability Testing Of A Mobile App For Use By Community-Dwelling Women, Janis M Miller, Jean F Wyman, Lawrence An, Haitao Chu, Cynthia S Fok, Missy Lavender, Cora Elizabeth Lewis, Alayne D Markland, Leslie M Rickey, Ying Sheng, Siobhan Sutcliffe, Lisa Kane Low, Elizabeth R Mueller
2020-Current year OA Pubs
BACKGROUND: Although surveys and apps are available for women to report urination and bladder symptoms, they do not include their decisions regarding toileting. Real-world factors can interfere with toileting decisions, which may then influence bladder health. This premise lacks data per want of a robust data collection tool.
OBJECTIVE: The Prevention of Lower Urinary Tract Symptoms (PLUS) research consortium engaged a transdisciplinary team to build and test WhereIGo, a mobile data collection app for Android and iOS. The design goal was a comprehensive reporting system for capturing environmental, sociocultural, and physical factors that influence women's decisions for toileting. Aims include …
Physiological And Psychological Differences Between 20% Grade Incline-Walking And Level-Grade Jogging At Isocaloric Intensity, Motoki Sato, Taj Krieger, Alexis D. Gidley, Brianne Weaver, Craig A. Johnson, David E. Lankford
Physiological And Psychological Differences Between 20% Grade Incline-Walking And Level-Grade Jogging At Isocaloric Intensity, Motoki Sato, Taj Krieger, Alexis D. Gidley, Brianne Weaver, Craig A. Johnson, David E. Lankford
International Journal of Exercise Science
International Journal of Exercise Science 17(6): 1318-1336, 2024. High-incline walking is a relatively new trend with little comparative information. This study compared physiological and psychological differences between high-incline walking at 20% grade (HIW) and level-grade jogging (LGJ) at isocaloric intensities in young adults. Twenty-two participants (M = 11, F = 11) aged 19–31 years completed the study. Participants completed HIW and LGJ on a treadmill for twenty minutes on two separate occasions and matched at isocaloric intensities. Rating of perceived exertion (RPE), maintainability (HCM), and affective valence using the Feeling Scale (FS) were measured at minutes 2, 10, and 20. …
Why The Elderly Are Targeted For Financial Cybercrimes: A Case Of South Africa, Tanweer Hamdulay, Chimwemwe Queen Mtegha, Wallace Chigona, Zwelithini Mabhena
Why The Elderly Are Targeted For Financial Cybercrimes: A Case Of South Africa, Tanweer Hamdulay, Chimwemwe Queen Mtegha, Wallace Chigona, Zwelithini Mabhena
African Conference on Information Systems and Technology
Financial cybercrime is growing in South Africa. The elderly population are a particularly vulnerable demographic to financial cybercrime. This research explores the factors contributing to financial cybercrime vulnerabilities among elderly citizens in disadvantaged communities in South Africa. A theoretical model based on Routine Activity Theory (RAT) was constructed. Findings from in-depth interviews show that cybercriminals take advantage of the elderly’s technology inexperience, using clever social engineering tactics and deceit to access personal and financial information. The study establishes a direct connection between low technology literacy and increased exposure to financial cybercrimes in South Africa, showing a dependence on younger family …
Research Progress On Health Care Function And Fruit Wine Of Aronia Melanocarpa, Tuo Longlong, Shi Pengbao, Chai Juhua, Shen Fei
Research Progress On Health Care Function And Fruit Wine Of Aronia Melanocarpa, Tuo Longlong, Shi Pengbao, Chai Juhua, Shen Fei
Food and Machinery
Based on recent domestic and foreign research results, the health care function and fruit wine development of Aronia melanocarpa were reviewed. The types and technology research progress of the fruit wine were emphasized, and the challenges and opportunities of current development of the fruit wine were analyzed.
Rehabilitation Impact Of Vivifrail Exercise Program Type C On The Cognitive Function Of Pre-Frail Elderly People In The Community, Sri Soenarti, Dwi Indriani Lestari, Muhammad Barlian Nugroho, Harien Lestari
Rehabilitation Impact Of Vivifrail Exercise Program Type C On The Cognitive Function Of Pre-Frail Elderly People In The Community, Sri Soenarti, Dwi Indriani Lestari, Muhammad Barlian Nugroho, Harien Lestari
Folia Medica Indonesiana
Highlights:
1. This study emphasizes the importance of providing physical exercises to pre-frail elderly individuals, especially in a community setting.
2. This study establishes a foundation for future research to explore the relationship between physical exercise, particularly the Vivifrail Type C Protocol, and cognitive function in pre-frail elderly individuals.
Abstract
Frailty is a clinical syndrome that increases vulnerability, potentially leading to disability or death. The pre-frail phase is ideal for preventing frailty and improving quality-adjusted life years, particularly through physical exercises that reduce the risk of dementia and cognitive impairment. Multicomponent exercises, such as the Vivifrail Exercise Program, may enhance …
In Memoriam: Pontus Palmgren, 1907-1993, Lars Von Haartman
In Memoriam: Pontus Palmgren, 1907-1993, Lars Von Haartman
The Auk
No abstract provided.
In Memoriam: Fran, Francois Vuilleumier
In Memoriam: Ben B Coffey, Jr, 1904-1993, Jerome A. Jackson
In Memoriam: Ben B Coffey, Jr, 1904-1993, Jerome A. Jackson
The Auk
No abstract provided.
Old Age And Breeding Behavior In A Tropical Passerine Bird Ploceus Cucullatus Under Controlled Conditions, N. E. Collias, E. C. Collias, C. H. Jacobs, C. R. Cox, F. A. Mcalary
Old Age And Breeding Behavior In A Tropical Passerine Bird Ploceus Cucullatus Under Controlled Conditions, N. E. Collias, E. C. Collias, C. H. Jacobs, C. R. Cox, F. A. Mcalary
The Auk
No abstract provided.
Ucc Minutes 10-8-24, Angela Brock
A Case Study: Do You Address Your Volunteers’ Well-Being Or Mental Health During The Covid-19 Pandemic? If So, How?, Daniel J. Robotham, Suzanna R. Windon, Ann E. Echols
A Case Study: Do You Address Your Volunteers’ Well-Being Or Mental Health During The Covid-19 Pandemic? If So, How?, Daniel J. Robotham, Suzanna R. Windon, Ann E. Echols
Journal of Extension
The uncertainty caused by the COVID-19 pandemic had a profound negative impact on volunteer mental health and well-being. We surveyed local non-profit organizational leaders about their practices toward addressing volunteer well-being and mental health during the COVID-19 pandemic. Study results indicated that while over a quarter of organizations did nothing to address volunteer well-being, other organizations utilized several approaches, including one-on-one and group meetings, program implementation, office culture investment, task assignment, and information dissemination. These findings provide valuable insight for Extension educators to develop community mental health and well-being programs to assist non-profit organizations' response to future uncertainty.
Suppressing Financial Exploitation Of Older Adults: A Social Work Perspective, Anthony J. Hill
Suppressing Financial Exploitation Of Older Adults: A Social Work Perspective, Anthony J. Hill
Forensic Scholars Today
Financial exploitation is a pervasive form of abuse or mistreatment of older adults. Social isolation and diminishing cognitive capacity are primary risk factors for financial exploitation among older adults. Researchers predict as the population ages, the incidents of older adults becoming victims of financial exploitation will increase. Social workers are well-poised to help suppress the crime of financial exploitation among older adults.
Conducting Comparative Effectiveness, Multisite Palliative Care And Advance Care Planning Trials: Lessons Learned And Future Directions From Pcori-Funded Studies, Areej El-Jawahri, Brittany Waterman, Susan Enguidanos, Lisa Gibbs, Victor Navarro, Maren Olsen, Jennifer Temel, Annette Totten, Corita R. Grudzen
Conducting Comparative Effectiveness, Multisite Palliative Care And Advance Care Planning Trials: Lessons Learned And Future Directions From Pcori-Funded Studies, Areej El-Jawahri, Brittany Waterman, Susan Enguidanos, Lisa Gibbs, Victor Navarro, Maren Olsen, Jennifer Temel, Annette Totten, Corita R. Grudzen
Department of Medicine Faculty Papers
The Patient-Centered Outcomes Research Institute (PCORI) funded multiple large-scale comparative effectiveness clinical trials evaluating palliative care (PC) and advance care planning (ACP) healthcare delivery models. This article provides an overview of the most common barriers our investigative teams encountered while implementing these trials and the strategies we utilized to overcome these challenges, with particular attention to identifying research partners for multisite trials; addressing contracting and regulatory issues; creating a team governance structure; training and engaging study staff across sites; recruiting, consenting, and enrolling study participants; collecting PC and ACP data and study outcomes; and managing multisite collaborations. The goal of …
Interviewing The Interviewers: How Qualitative Professors Assess Interviews In Their Classes, Meredith C. Massey, Leia K. Cain
Interviewing The Interviewers: How Qualitative Professors Assess Interviews In Their Classes, Meredith C. Massey, Leia K. Cain
The Qualitative Report
When reviewing the literature relating to what instructors of qualitative research courses are teaching in their courses, we found a gap regarding qualitative faculty's motivations behind what they teach and whether they use teaching tools such as rubrics in their assessment practices. We utilized general qualitative methods to explore and describe how instructors of qualitative methodology courses conceptualize and design interview-based assessments. By conducting structured interviews with five faculty members, we embraced interpretivist descriptive traditions and sought to obtain thick, rich descriptions of each participant’s perspectives and experiences. After coding interview transcripts, we created themes to represent participant beliefs that …
A Survey Of Early-Career Speech-Language Pathologists: Determining Perceived Readiness For Clinical Management Of Adults With Dysphagia After Completing Graduate School, Christine A. Lee, Ashwini Namasivayam-Macdonald, Zuleikha Wadhwaniya, Juliana Mclaren, Rebecca H. Affoo
A Survey Of Early-Career Speech-Language Pathologists: Determining Perceived Readiness For Clinical Management Of Adults With Dysphagia After Completing Graduate School, Christine A. Lee, Ashwini Namasivayam-Macdonald, Zuleikha Wadhwaniya, Juliana Mclaren, Rebecca H. Affoo
Teaching and Learning in Communication Sciences & Disorders
Several studies have identified a recurring trend that speech-language pathologists (S-LPs) in countries such as the United States (Caesar & Kitila, 2020), South Africa (Singh et al., 2015), and Malaysia (Kamal et al., 2012) report lower levels of confidence in dysphagia management, whether in comparison to other practice areas or in certain skill areas within the specialty of dysphagia. No data currently exists exploring self-perceptions of Canadian S-LP graduates with regards to clinical management of adults with dysphagia. Therefore, the purpose of this study was to determine the self-reported readiness of recently graduated Canadian S-LPs who manage dysphagia. Our survey …
Changes In Multimorbidity Among Hospitalized Adults In The Us, Christine Loyd, Lauren Picken, Richelle Sanders, Yue Zhang, Richard E. Kennedy, Cynthia J. Brown
Changes In Multimorbidity Among Hospitalized Adults In The Us, Christine Loyd, Lauren Picken, Richelle Sanders, Yue Zhang, Richard E. Kennedy, Cynthia J. Brown
School of Medicine Faculty Publications
OBJECTIVE: This investigation examines burden of comorbidity measured by the Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index (ECI) among inpatients based on age, sex, and race. METHODS: Cross-sectional analysis of 2012-2018 US NIS datasets. Participants were inpatients 55y+. ICD-9/10 codes for admitting diagnoses were used to calculate disease burden using the CCI and ECI. Unweighted mean CCI and ECI scores were compared across demographic variables. RESULTS: An increase in mean CCI and ECI scores across age, sex, and races (p < .001) was identified. Compared to the youngest age group (55-59y), all age groups had higher mean CCI and ECI adjusting for time (p < .001). Increases were greatest in older age groups until age 80-84 for CCI and 85-89 for ECI. The female group had lower CCI adjusting for time (p < .001) compared to males. There was no difference between sex groups in mean ECI (p=.409). Compared with the White group, all other race groups had higher mean CCI adjusting for time (p < .001). Black inpatients had the highest CCI followed by Native American inpatients. Findings were similar for ECI, but with no difference between Hispanic and White groups (p=.434). CONCLUSIONS: Growing multimorbidity burden among adult inpatients across age, sex, and race supports the continued need for programs for preventing and reducing multimorbidity, especially among communities that experience health inequity including older, Black, and Native American patients.
Prostate-Specific Antigen Testing Patterns And Prostate Cancer Stage At Diagnosis In Older Ohio Cancer Patients, Sajan N. Patel, Long Vu, Holly E. Hartman, Weichuan Dong, Siran M. Koroukian, Johnie Rose
Prostate-Specific Antigen Testing Patterns And Prostate Cancer Stage At Diagnosis In Older Ohio Cancer Patients, Sajan N. Patel, Long Vu, Holly E. Hartman, Weichuan Dong, Siran M. Koroukian, Johnie Rose
Faculty Scholarship
Background: Prostate cancer (PCa) screening recommendations do not support prostate-specific antigen (PSA) screening for older men. Such screening often occurs, however. It is, therefore, important to understand how frequently and among which subgroups screening occurs, and the extent of distant stage PCa diagnoses among screened older men. Methods: Using the 2014–2016 linked Ohio Cancer Incidence Surveillance System (OCISS) and Medicare administrative database, we identified men 68 and older diagnosed with PCa and categorized their PSA testing in the three years preceding diagnosis as screening or diagnostic. We conducted multivariable logistic regression analysis to identify correlates of screening PSA and to …
Experience Of Loneliness Among Older People In Hong Kong : Ageism Perspective, Chi Kuen Wong
Experience Of Loneliness Among Older People In Hong Kong : Ageism Perspective, Chi Kuen Wong
Lingnan Theses (MPhil & PhD)
The experience of loneliness is a significant concern among older people, as it can lead to serious health risks and impact overall well-being. This study, conducted in Hong Kong, explores the relationship between ageism and loneliness among older individuals. Employing qualitative research methods and thematic analysis, data were collected from 21 community-dwelling participants aged 65 to 86, including 8 males and 13 females.
The research focuses on how older individuals' experiences and perceptions of ageism contribute to feelings of loneliness. The study examines different forms of ageism, including institutional ageism and social exclusion, interpersonal ageism, and internalized ageism, as well …
Glycemic Control In Diabetic Patients Improved Overall Lung Cancer Survival Across Diverse Populations, Wayne Y Wu, Brian Luke, Xiao-Cheng Wu, J Jack Lee, Yong Yi, Samuel C Okpechi, Barry Gause, Paras Mehta, Steven I Sherman, Augusto Ochoa, Ethan Dmitrovsky, Xi Liu
Glycemic Control In Diabetic Patients Improved Overall Lung Cancer Survival Across Diverse Populations, Wayne Y Wu, Brian Luke, Xiao-Cheng Wu, J Jack Lee, Yong Yi, Samuel C Okpechi, Barry Gause, Paras Mehta, Steven I Sherman, Augusto Ochoa, Ethan Dmitrovsky, Xi Liu
Faculty, Staff and Student Publications
Background: The consequence of diabetes on lung cancer overall survival (OS) is debated. This retrospective study used 2 large lung cancer databases to assess comprehensively diabetes effects on lung cancer OS in diverse demographic populations, including health disparity.
Methods: The University of Texas MD Anderson Cancer Center database (32 643 lung cancer patients with 11 973 patients with diabetes) was extracted from electronic health records (EHRs) using natural language processing (NLP). Associations were between diabetes and lung cancer prognostic features (age, sex, race, body mass index [BMI], insurance status, smoking, stage, and histopathology). Hemoglobin A1C (HgbA1c) and glucose levels assessed …
Testamentary Freedom: A Constitutional Perspective, Richard J. Goralewicz
Testamentary Freedom: A Constitutional Perspective, Richard J. Goralewicz
ACTEC Law Journal
No abstract provided.
Ce 640 Syllabus: Orientation To Clinical Mental Health Counseling, Karen Cathey
Ce 640 Syllabus: Orientation To Clinical Mental Health Counseling, Karen Cathey
Counselor Education Syllabi
This course examines the counseling profession including history, philosophy, theory, and professional issues. Emphasis is on different counseling populations, social justice and multicultural issues.
Ce 640 Syllabus: Orientation To Clinical Mental Health Counseling, Rieko Miyakuni
Ce 640 Syllabus: Orientation To Clinical Mental Health Counseling, Rieko Miyakuni
Counselor Education Syllabi
This course examines the counseling profession including history, philosophy, theory, and professional issues. Emphasis is on different counseling populations, social justice and multicultural issues.
孫輩照顧者面對的挑戰研究報告, Chak Kwan, Dickon Chan, Kong Sang Lou, Meng Soi, Florence Fong, Sheung Wan, Wanda Wong, Ka Chung, Tom Kwong
孫輩照顧者面對的挑戰研究報告, Chak Kwan, Dickon Chan, Kong Sang Lou, Meng Soi, Florence Fong, Sheung Wan, Wanda Wong, Ka Chung, Tom Kwong
APIAS Research Report 研究報告
背景和目的
香港人口老齡化和長期病患者的增加,令到更多老年人需要人照顧。現時社會對孫輩照顧者的認識不足,使到他們缺乏適切支援服務。本研究旨在探索孫輩照顧殘疾或患有慢性疾病的祖父母的情況,並提出政策與服務建議。嶺南大學亞太老年學研究中心聯同救世軍護老者協會及救世軍護老者服務於2024年4月25日舉辦了「孫輩照顧者的需要、實踐及政策」研討會,各方持份者分享他們對支援孫輩照顧者的經驗和看法,共同尋找方案支援這類照顧者。
研究方法
本研究於2023年4月至12月期間,採用深度訪談 (in-depth interview) 方式,訪問了共40位年齡介乎13至63歲的孫輩照顧者,瞭解他們成為照顧者的主要原因、提供了甚麼照顧,以及照顧過程中面對的困難。
研究結果
- 大部分受訪的孫輩照顧者 (67.5%) 為次照顧者,近半受訪者每周提供20小時以上的照顧工作。
- 共有47位祖父母/外祖父母受到照顧,年齡介乎62至99歲。大部分被照顧者 (91.5%) 行動不便,或患有長期病患 (76.6%)。被照顧祖父母當中過半 (57.4%) 沒有與孫輩同住,8.5%為獨居。
- 孫輩成為照顧者有數個原因,包括家庭成員無法提供照顧、減輕父母的壓力和回饋祖父母過往照顧之恩。
- 孫輩照顧者的照顧角色與他們的年齡、生活狀態、能力,以及被照顧者的需要有關。大部分孫輩照顧者和家人分擔照顧工作,並得到他們的協助。孫輩照顧者會主動運用各種輔助設備,以提高照顧成效。
- 孫輩照顧者除了要面對一般照顧者的困難外 (如支援服務及資訊不足、身心壓力和社交限制),他們面對的壓力還包括學業及就業、家庭角色的衝突、「夾心」照顧者面對多重壓力,以及缺乏社會的認同。
- 政策建議
研究報告建議政府須加強院校對就學照顧者的支持、提供額外假期予在職照顧者、將照顧者主題納入中學課程、推廣朋輩支援小組、提供線上及晚間照顧技巧課程、開發多元化暫託服務、建立個案管理制度,以及推動樂齡科技之運用。
Regulation Of P21 Function By A Sense Long Non-Coding Rna Generated By Alternative Polyadenylation, Anthony Ramadei
Regulation Of P21 Function By A Sense Long Non-Coding Rna Generated By Alternative Polyadenylation, Anthony Ramadei
Dissertations, Theses, and Capstone Projects
As cells are continually undergoing damage to the genome, a coordinated change in gene expression across thousands of genes is required for the progression of the DNA damage response (DDR). After initial sensing of DNA damage, the transcription factor p53 induces expression of target genes to halt the cell-cycle to allow DNA repair and induce either senescence or apoptosis. One of the p53 target genes is CDKN1A which encodes the cyclin dependent kinase inhibitor p21. p21 halts cell-cycle progression in response to DNA damage and can also induce senescence. However, p21 expression in cancer cells undergoing chemotherapy allows survival by …
The Long Arm Of School Punishment: The Role Of School Suspension On Self-Rated Health From Adolescence To Midlife, Michael Niño, Alexa Angton, Kathryn Norton-Smith, Kayla Allison
The Long Arm Of School Punishment: The Role Of School Suspension On Self-Rated Health From Adolescence To Midlife, Michael Niño, Alexa Angton, Kathryn Norton-Smith, Kayla Allison
Sociology and Criminology Faculty Publications and Presentations
School suspension has been linked to numerous adverse social outcomes in adolescence and adulthood. While research continues to highlight the deleterious consequences tied to suspension, less is known about how exposure to suspension influences health over the life course. Drawing from panel data, we address this gap by investigating whether school suspension is associated with self-rated health from adolescence to midlife. Compared to youth with no history of suspension, suspended youth were more likely to report poorer health in adolescence. Findings also demonstrate that school suspension plays a significant role in self-rated health patterns over time. Specifically, we find suspended …
Self-Perceived Cognitive Functioning In Motoric Cognitive Risk Syndrome: Enhancing Risk Detection In Health Disparity Older Adults, Caroline O. Nester
Self-Perceived Cognitive Functioning In Motoric Cognitive Risk Syndrome: Enhancing Risk Detection In Health Disparity Older Adults, Caroline O. Nester
Dissertations, Theses, and Capstone Projects
Motoric Cognitive Risk Syndrome (MCR) is a predementia condition that combines two clinical presentations associated with dementia: slow gait speed and subjective cognitive concerns (SCC). MCR diagnosis is associated with increased risk for dementia over its individual components of SCC or slow gait alone, making it a valuable marker of early neurodegenerative changes. MCR does not require expensive, time-consuming assessments to be diagnosed, broadening accessibility in remote or under-resourced settings. At present, there is no consistent method to assess SCC in MCR – a key diagnostic feature of the syndrome. The lack of understanding about SCC in MCR may limit …
Geriatric Nutritional Risk Index Predicts Postoperative Delirium In Elderly: A Meta-Analysis, Siye Xie, Qi Wu
Geriatric Nutritional Risk Index Predicts Postoperative Delirium In Elderly: A Meta-Analysis, Siye Xie, Qi Wu
Saudi Medical Journal
Objectives: To review current evidence on using the geriatric nutritional risk index (GNRI) in predicting postoperative delirium (POD) in elderly patients. Methods: The literature search was performed in core databases to include all the cohort studies on the association between GNRI and risk of POD for further meta-analysis. Results: A total of 6 studies with 4242 patients underwent this meta-analysis, which showed that the risk of POD was higher in patients with moderate and high GNRI than the ones with low GNRI (odds ratio [OR]=2.04, 95% confidence interval [CI] [1.58, 2.64], p <0.001), and moderate and high GNRI significantly increased the risk of POD in patients of 60 to 75 years or above [OR=1.98, 95%CI (1.49, 2.62), p <0.001; OR=2.79, 95%CI (1.38, 5.64), p =0.004, respectively]. Conclusion: Therefore, moderate and high GNRI increased the risk of POD in elderly patients.
Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Rui Xia, Xueqiu Jian, Amanda L Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L Daviglus, Charles Decarli, Linda C Gallo, David C Glahn, Emma E M Knowles, Jee-Young Moon, Thomas H Mosley, Claudia L Satizabal, Tamar Sofer, Wassim Tarraf, Fernando Testai, John Blangero, Sudha Seshadri, Hector M González, Myriam Fornage
Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Rui Xia, Xueqiu Jian, Amanda L Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L Daviglus, Charles Decarli, Linda C Gallo, David C Glahn, Emma E M Knowles, Jee-Young Moon, Thomas H Mosley, Claudia L Satizabal, Tamar Sofer, Wassim Tarraf, Fernando Testai, John Blangero, Sudha Seshadri, Hector M González, Myriam Fornage
Faculty, Staff and Student Publications
INTRODUCTION: We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities.
METHODS: We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.
RESULTS: We identified nine local ancestry-associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.
DISCUSSION: Our …
Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Rui Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles Decarli, Linda C. Gallo, John Blangero
Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Rui Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles Decarli, Linda C. Gallo, John Blangero
School of Medicine Publications
Introduction: We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities.
Methods: We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.
Results: We identified nine local ancestry-associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.
Discussion: Our …