Digital Commons Network^™

Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Ru Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles S. Decarli, Linda C. Gallo, John Blangero

School of Medicine Publications

Introduction: We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities.

Methods: We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.

Results: We identified nine local ancestry-associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.

Discussion: Our …

Do Pedestrian Safety Improvements Affect Older Adults' Health And Social Outcomes Equitably? A Quasi Experiment In Singapore, Shin Bin Tan, William Tov, Paulin Tay Straughan

Research Collection School of Social Sciences

Pedestrian-friendly neighborhoods are believed to encourage greater social participation, community engagement, and sense of social inclusion, which are important to older individuals at higher risk of being socially isolated. However, most studies on neighborhood walkability, social participation and social inclusion are cross-sectional, making it difficult to robustly establish causal links. Much research on neighborhood walkability is also based in North America and Europe, leaving a knowledge gap on the impact of walkability within other geographic contexts. Furthermore, there is a lack of empirical evidence about whether benefits from traffic calming schemes are distributed equitably. To reduce these empirical gaps, our …

The Importance Of Sampling Frequency For Estimates Of Well-Being Dynamics, Stephen James Hoskins, David W. Johnston, Johannes S. Kunz, Michael A. Shields, Kevin E. Staub

ROSA Journal Articles and Publications

Using a high-frequency panel survey, we examine the sensitivity of estimated self-reported well-being (SWB) dynamics to using monthly, quarterly, and yearly data. This is an important issue if SWB is to be used to evaluate policy. Results from autoregressive models that account for individual-level heterogeneity indicate that the estimated persistence using yearly data is near zero. However, estimated persistence from monthly and quarterly data is substantial. We estimate that persistence to shocks typically lasts around six months and has a net present value of 75–80 per cent of the contemporaneous effect. Estimates are similar for different domains of SWB.

Dementia-Focused Programs In Older Adult Centers And Health Care Use Among Individuals With Dementia, Ayse Akincigil, Divya Bhagianadh, Clara J. Scher, Ceara Somerville, Caytln Coyle, Natalie E. Pope, Emily Greenfield

Health, Human Performance and Recreation Faculty Publications and Presentations

There is growing attention to community-based services for preventing adverse health care outcomes among people aging with dementia. We explored whether the availability of dementia-centered programming within older adult centers (ie, senior centers)—specifically, adult day services (ADS), social adult day centers (SADCs), memory cafes, and caregiver support—is associated with reduced hospitalization, emergency room use, and total Medicare costs for community-dwelling individuals ages 75 and older with Alzheimer's disease and related dementias (ADRD), and whether associations differ by the relative size of the local jurisdiction. We used a novel dataset that links Medicare claims data with data from an organizational census …

The Implementation Of A Fall Education Program To Enhance Functional Outcomes In An Acute Orthopedic Hospital Setting, Stacy Wentz Ms, Otr/L, Jared Schnell Pt, Dpt, Haily Roth Pt, Dpt

Department of Medicine

No abstract provided.

Histopathological Evaluation Of Geriatric Ophthalmic Veins: A Cadaveric Study, Farida Mehrhoff, Keanna Theobalt, Alla G. Barry, Robert Hillard

Student Publications

Context: The ophthalmic vein (OV) has become a source of increasing curiosity since many aspects of vascular surgery of the orbit have become feasible. At the same time, histochemical analysis of veins, in general, tends to skip the OV. Moreover, age‑related changes in the OVs remain untouched. Aims: Our research explores features of aging in the OV. Settings and Design: We immunohistochemically evaluated the superior and inferior OVs in 49 orbits of 28 formalin‑embalmed human cadavers (age 77.86 ± 13.38) without visible vascular malformations. Materials and Methods: Specimens were stained by hematoxylin and eosin. Verhoeff, laminin, and CD31 stains were …

Older And Better: A Narrative Review Of Successful Aging And Adaptation To Pain In Late Life, Emanuel Narcis Husu

Faculty, Staff and Students Publications

"Invariably, the self-assessed QoL was far better than I, as a physician, would have anticipated from the diseases and disabilities that you reported." -Ben Eiseman, MD, based on a survey of his octogenarian Yale University classmates.

Background: Chronic pain control is a high priority for the elderly; it is one of the most frequently encountered medical problems in this group. Chronic pain affects 60%-75% of people aged 65 years and older. Chronic pain's prevalence is even higher in those living in assisted living or nursing homes. Based on epidemiological data, the prevalence of chronic pain is directly proportional to age …

An Interpretable Machine Learning-Based Cerebrospinal Fluid Proteomics Clock For Predicting Age Reveals Novel Insights Into Brain Aging, Justin Melendez, Yun Ju Sung, Miranda Orr, Andrew Yoo, Suzanne Schindler, Carlos Cruchaga, Randall Bateman

2020-Current year OA Pubs

Machine learning can be used to create "biologic clocks" that predict age. However, organs, tissues, and biofluids may age at different rates from the organism as a whole. We sought to understand how cerebrospinal fluid (CSF) changes with age to inform the development of brain aging-related disease mechanisms and identify potential anti-aging therapeutic targets. Several epigenetic clocks exist based on plasma and neuronal tissues; however, plasma may not reflect brain aging specifically and tissue-based clocks require samples that are difficult to obtain from living participants. To address these problems, we developed a machine learning clock that uses CSF proteomics to …

The Minutes Of The Marshall University Graduate Council Meeting, August 30, 2024, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

Fall Risk On Laboratory Instrumented Stairways, Parker Nelson

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Using The Home Health Oasis To Promote Advance Care Planning Among Community-Dwelling, Frail Older Adults, Suzanne S. Sullivan

Dissertations

Despite an aging population with increasing proportions of frailty and decline, the rates of documented Advance care plans (ACP), meant to align goals for care with the level of treatment at end-of-life (EOL), are low (~30-40%). Patients expect clinicians to raise the question about serious illness goals for care when the time is right, however, there are a number of barriers to the initiation of these difficult conversations including provider bias and uncertainty. A review of the literature indicates that there are few prognostic indices available for use to identify the right time to initiate EOL conversations based on risk …

Increasing Self-Efficacy Of Nurse Practitioner Preceptors In Primary Care By Using The One-Minute Preceptor Model, Amy J. Lancaster

Doctoral Dissertations and Projects

Nurse practitioners represent the fastest growing profession in the United States, with 385,000 practitioners currently licensed. Over 70% of these licensed practitioners are serving in primary care settings. As the growth of this workforce continues, so does the need for nurse practitioner preceptors. The preceptor plays an essential role in championing clinical competencies for nurse practitioner students. This project was implemented in a primary care setting with an aim to improve the self-efficacy of nurse practitioner preceptors by using the One-Minute Preceptor teaching method to improve the practicum experience for both the preceptor and the nurse practitioner student. The One-Minute …

A Qualitative Study On Transnational Caregiving For Older Parents In China, Silai Dong

Lingnan Theses (MPhil & PhD)

The increasing number of international migrations in China poses challenges for the care of older parents who are left behind, considering China’s emphasis on family support. This study aims to investigate transnational care arrangements for older parents whose children are overseas. It mainly addresses three research questions:1) What are the contents of filial piety in the context of international migration? 2) How do Chinese transnational family members negotiate and distribute elder care responsibilities? 3) To what extent can the transnational caregiving model explain elder care in Chinese transnational families?

The transnational caregiving model proposed by Baldassar, Baldock, and Wilding, in …

Unraveling The Role Of Hid-1: Insights Into Sgii Regulation, Breanna L. Sellers

Electronic Theses and Dissertations

The regulated secretory pathway is important for the secretion of hormones and neuropeptides from large dense core vesicles (LDCVs). Dysregulation of the biogenesis of LDCVs can result in metabolic and neurological diseases. Recent studies have suggested that the peripheral membrane protein HID-1 plays a role in the sorting and storage of granins which contribute to LDCV biogenesis. To further understand how HID-1 influences the regulation of granins, we investigated potential HID-1 interactors. We determined that while HID-1 is likely functioning in the same pathway as USP25, a deubiquitinating enzyme (DUB), the cause of reduced cellular SgII levels is likely not …

Southern Adventist University Commencement Program Summer 2024, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Summer 2024 graduation. The commencement service occurred on August 23, 2024 at 10 am in Iles Physical Education Center.

Dancing In Chains: Policy Influence Of Social Organizations In China, Honggang Tan

Dissertations - ALL

The growth of Chinese social organizations has attracted attention from researchers and practitioners because it reflects the changing state-society relations in post-Mao China and has profound implications for the country’s political development. As a mediating structure between the state and citizens, they are supposed to represent their constituencies in the policy arena. The existing research records many social organizations’ policy activities. However, do all social organizations engage in such activities? If not, what organizations are active, less active, or inactive? Furthermore, what factors shape their different behaviors and determine different levels of policy influence? Regarding organizations with policy engagement, what …

Prevalence And General Characteristics Of Dementia: A Nationwide Population-Based Study Of Electronic Health Records In Türkiye, Merve Güner, Meltem Koca, Serdar Ceylan, Arzu Okyar Baş, Ayşe Di̇kmeer, Mert Eşme, Osman Çeli̇k, Mustafa Okan Ayvali, Murat Çağlayan, Mustafa Mahi̇r Ülgü, Gülni̇hal Gökçe Ünal, Cafer Balci, Nai̇m Ata, Mustafa Cankurtaran, Burcu Balam Doğu, Şuayi̇p Bi̇ri̇nci̇

Turkish Journal of Medical Sciences

Background/aim: Türkiye is a country with an increasing life expectancy and an older adult population in parallel with the rest of the world. Several national small-scale studies were performed regarding the prevalence and characteristics of dementia in Türkiye, and the results of these studies differ from each other. We aimed to determine the prevalence of dementia in Türkiye to present the demographic characteristics, the frequency of use of health services, and the management of dementia.Materials and methods: Patients aged 65 years and over with a diagnosis of any type of dementia between January 1, 2019, and December 31, 2020, were …

Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful In The Follow-Up Of Cognitive Functions In Cognitively Normal Parkinson’S Disease Patients?, Hasan Armağan Uysal, Duygu Hünerli̇, Rai̇f Çakmur, Beri̇l Dönmez Çolakoğlu, Emel Ada, Görsev Yener

Turkish Journal of Medical Sciences

Background/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson’s disease (PD-CN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients.Materials and methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and …

Relationship Between Functional Status And Fatigue After Covid-19 Infection: A Multicenter Study From Türkiye, İpek Candemi̇r, Pinar Ergün, Di̇cle Kaymaz, Mustafa Engi̇n Şahi̇n, İpek Özmen, Eli̇f Yildirim, Asli Görek Di̇lektaşli, Büşra Yi̇ği̇tli̇ler, Ayten Odabaş, Deni̇z Kizilirmak, Seçi̇l Sari, Celaletti̇n Korkmaz, Cantürk Taşçi, Yakup Arslan, Sema Savci, Buse Kahraman, Ayli̇n Tanriverdi̇, Can Sevi̇nç, Melda Sağlam, Deni̇z İnal İnce, Naci̇ye Vardar Yağli, Ebru Kütükçü, Di̇lber Durmaz, Nesli̇han Durutürk, Gaye Ulubay, Lütfi̇ye Kiliç, Benan Çağlayan, Ayli̇n Moray, Sabri̇ Serhan Olcay, Güven Özkaya

Turkish Journal of Medical Sciences

Background/aim: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address.. Materials and methods: Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence …

From Reflection To Resumes: Alumni Perceptions Of A Multi-Term Public Service Program’S Connection To Career, Ryan Nilsen, Alanna Gillis, Bryant Hutson, Lynn Blanchard

Journal of Community Engagement and Higher Education

This paper explores how alumni of a multi-term public service program understand the connection between the program and their career development. Qualitative data were collected from 393 alumni based on six open-ended survey questions. While career and professional development is not an explicit goal of the program, a thematic analysis suggests that alumni perceived that the program connected to career reflection, boosted their resume, and guided them toward a public service career or specific jobs.

Social Theories And Service Learning: Towards Building An Integrated Service-Learning Sociological Framework, Mark Anthony D. Abenir, Carol Ma Hok Ka

Journal of Community Engagement and Higher Education

This theoretical paper anchors service learning (S-L) in three broad sociological theories. From there, discussions on the actual implementation of S-L based on these theories are explained to build an integrated S-L sociological framework. Four S-L modalities of community engagement are identified—namely transactional, transitional, transformational, and transcendental—with their corresponding respective levels of community participation—namely consultative tokenism, placation, partnerships, and citizen control. The application of such a coherent framework is discussed in the context of contemporary service-learning practices and community impact.

Service Learning In Physical Therapy Professional Education: Student Reflections Of The Special Olympics Funfitness Program, Stasia Tapley, Howell Tapley, Tiffany Idlewine, John Kiesel

Journal of Community Engagement and Higher Education

The Special Olympics (SO) FUNfitness Program involves a comprehensive screening for flexibility, strength, balance, and aerobic fitness for individuals with intellectual disability (ID). Doctor of Physical Therapy students at Indiana State University administer the program yearly as part of the Indiana SO Summer Games. Thematic analysis of student reflections revealed increased awareness of individuals with ID, both beneficial and challenging aspects of the experience, and increased likelihood of working with underserved populations in the future.

Connections: Building Partnerships With Museums To Promote Intergenerational Service Learning And Alzheimer’S Care, Catherine Wilkins

Journal of Community Engagement and Higher Education

This article reflects upon the development of Connections, a service-learning collaboration between a Research I university and an urban art museum that trains students to work with patient groups from the community using Visual Thinking Strategies. This method of art exploration helps people with Alzheimer’s disease express memories and relieve anxiety. In describing the collaboration, instructional design, and ongoing research, this reflection seeks to encourage educators to partner with museums for intergenerational service-learning experiences.

Social And Cognitive Outcomes Of Service Learning: Results From A Pre-Post And Control Group Comparison, Rebecca G. Ryan

Journal of Community Engagement and Higher Education

Students in an undergraduate course opted to either complete a service-learning project or write article summary papers over the course of a semester. Analyses revealed a significant increase in aspects of empathy, social responsibility, and community and personal involvement in the service-learning group, but not in the control group. The findings are discussed in terms of the social and cognitive benefits of service learning and considerations for incorporating service learning into a gerontology-related course.

A Comprehensive Community Awareness Website To Increase Screening Colonoscopy Rates Among Adults In Flower Mound, Tx, Alexandra Biltz

Doctor of Nursing Practice Final Project Abstract

PURPOSE Colorectal cancer is the second leading cause of cancer-related deaths in both men and women. The purpose of this scholarly project was to implement a website and flyer to increase screening colonoscopy rates in adults ages 45 to 75.

BACKGROUND There are no formal models or guidelines for increasing screening colonoscopies in the United States. The literature search also revealed that many Americans do not have a good general knowledge of colorectal cancer and colonoscopies.

The project was implemented at an ambulatory gastrointestinal endoscopy center in Flower Mound, Texas.

METHODOLOGY The website was created using Wix and a flyer …

A Systematic Review Of Oral Vertical Dyskinesia ("Rabbit" Syndrome), Jamir Pitton Rissardo, Krish Kherajani, Nilofar Murtaza Vora, Venkatesh Yatakarla, Ana Letícia Fornari Caprara, Jeffrey Ratliff, Md, Stanley N Caroff

Department of Neurology Faculty Papers

Background and Objectives: Vertical rhythmic dyskinetic movements that are primarily drug-induced and affect solely the jaw, mouth, and lips without involving the tongue have been historically described as “rabbit” syndrome (RS). Evidence on the unique features and implications of this disorder remains limited. This literature review aims to evaluate the clinical–epidemiological profile, pathological mechanisms, and management of this movement disorder. Materials and Methods: Two reviewers identified and assessed relevant reports in six databases without language restriction published between 1972 and 2024. Results: A total of 85 articles containing 146 cases of RS were found. The mean frequency of RS among …

Staying Curious, Stephanie Voisine

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Companion Dogs And Depression, Anxiety, And Posttraumatic Stress Disorder In Adult Icu Survivors: A Scoping Review, Lindsey Nelson, Sue Lasiter, Amanda Emerson

People and Animals: The International Journal of Research and Practice

Intensive care unit (ICU) survivors are at risk for developing persistent psychological sequelae that have been linked to decreased quality of life and increased mortality after hospital discharge. Standardized evidence-based treatments are lacking, mainly focus on physical rather than psychological recovery, and often occur in formal settings. Benefits of human– companion dog relationships have not been explored in the ICU survivor population before. Thus, the purposes of our review were to summarize the literature focused on the influence of companion dogs on depression, anxiety, and posttraumatic stress disorder (PTSD); identify what is known about the potential role companion dogs play …

Development Of An Examiner-Examinee Rapport Scale For Neuropsychological Testing: The Barnett Rapport Questionnaire – 2, Jenna Moore

Clinical Psychology Dissertations

Rapport in the context of neuropsychological testing refers to the interpersonal interaction between the examinee and examiner. The purpose of this study was to improve upon the original Barnett Rapport Questionnaire. Participants consisted of college students (n = 55), middle-aged adults (n = 30), and older adults (n = 99) at a university-affiliated neuropsychology clinic, who were administered a brief neuropsychological battery. After testing, both examinees (n = 184) and examiners (n = 24) completed items regarding the nature of the interpersonal interaction. Exploratory factor analysis indicated a two-factor model consisting of 13 items found on both the examinee and …

Gender Differences In Relations Between Social Comparison, Social Support, And Sleep Disturbance Among Midlife And Older Adults., Iris Bercovitz, Gabrielle M Salvatore, Jacqueline A Mogle, Danielle Arigo

College of Science & Mathematics Departmental Research

OBJECTIVE: To examine associations between sleep disturbance, social support, and social comparison among midlife and older adults, including the moderating role of gender.

METHODS: Adults ages ≥40 years (N = 557, MAge = 57, 53% men) completed a cross-sectional survey including validated measures of sleep disturbance, perceptions of social support, and social comparison orientation.

RESULTS: Sleep disturbance was negatively associated with social support (rs = −0.42 to–0.33, ps = 0.001) and associations were stronger for men than women–particularly perceived support from friends (η 2= 0.01). Sleep disturbance was also associated with upward comparison orientation (r = 0.12, p = 0.003), …