Digital Commons Network^™

Identification Of Proteins Associated With Type 2 Diabetes Risk In Diverse Racial And Ethnic Populations, Shuai Liu, Jingjing Zhu, Hua Zhong, Chong Wu, Haoran Xue, Burcu F Darst, Xiuqing Guo, Peter Durda, Russell P Tracy, Yongmei Liu, W Craig Johnson, Kent D Taylor, Ani W Manichaikul, Mark O Goodarzi, Robert E Gerszten, Clary B Clish, Yii-Der Ida Chen, Heather Highland, Christopher A Haiman, Christopher R Gignoux, Leslie Lange, David V Conti, Laura M Raffield, Lynne Wilkens, Loïc Le Marchand, Kari E North, Kristin L Young, Ruth J Loos, Steve Buyske, Tara Matise, Ulrike Peters, Charles Kooperberg, Alexander P Reiner, Bing Yu, Eric Boerwinkle, Quan Sun, Mary R Rooney, Justin B Echouffo-Tcheugui, Martha L Daviglus, Qibin Qi, Nicholas Mancuso, Changwei Li, Youping Deng, Alisa Manning, James B Meigs, Stephen S Rich, Jerome I Rotter, Lang Wu

Faculty, Staff and Student Publications

Aims/hypothesis: Several studies have reported associations between specific proteins and type 2 diabetes risk in European populations. To better understand the role played by proteins in type 2 diabetes aetiology across diverse populations, we conducted a large proteome-wide association study using genetic instruments across four racial and ethnic groups: African; Asian; Hispanic/Latino; and European.

Methods: Genome and plasma proteome data from the Multi-Ethnic Study of Atherosclerosis (MESA) study involving 182 African, 69 Asian, 284 Hispanic/Latino and 409 European individuals residing in the USA were used to establish protein prediction models by using potentially associated cis- and trans-SNPs. The models were …

Designing A Blockchain Technology Platform For Enhancing The Pre-Exposure Prophylaxis Care Continuum, Anjum Khurshid, Daniel Toshio Harrell, Dennis Li, Camden Hallmark, Ladd Hanson, Nishi Viswanathan, Michelle Carr, Armand Brown, Marlene Mcneese, Kayo Fujimoto

Faculty, Staff and Student Publications

OBJECTIVES: Pre-exposure prophylaxis (PrEP) is a key biomedical intervention for ending the HIV epidemic in the United States, but its uptake is impeded by systemic barriers, including fragmented workflows and ineffective data coordination. This study aims to design PrEPLinker, a blockchain-based, client-centered platform to enhance care to address these challenges by improving care coordination and enabling clients to securely manage their identity and PrEP-related data.

MATERIALS AND METHODS: Using Houston, Texas, as a use case, we conducted a needs assessment with PrEP collaborators to evaluate existing workflows and identify barriers in the PrEP care continuum. Based on these findings, we …

Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project;, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso

Faculty, Staff and Student Publications

INTRODUCTION: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.

METHODS: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data.

RESULTS: Pooled-population analyses of all individuals identified genetic variants at apolipoprotein E (APOE) and BIN1 associated with AD (p < 5 × 10

DISCUSSION: We observed that complementary pooled-population and subgroup-specific analyses offered unique insights into the genetic architecture of AD.

HIGHLIGHTS: We determine the association of genetic variants with Alzheimer's disease (AD) using …

Effectiveness Of Enhanced Care For Treatment Of Acute Or Persistent Diarrhea In Malnourished Children Aged 0 Months To 10 Years: A Systematic Review, Ridwa Alam, Khadija Vadsaria, Ahmad Khan, Uswa Jiwani, Aqsa Ishaq, Anmol Minaz, Ashraf Sharif, Jai K. Das, Sajid Bashir Soofi, Shabina Ariff

Centre of Excellence in Women and Child Health

Background: Diarrhea poses a significant public health challenge, particularly affecting children under five. The link between malnutrition and diarrhea is well established, with diarrhea being a primary cause of malnutrition in young children and malnutrition exacerbating the severity of diarrhea. While the World Health Organization (WHO) recommends a comprehensive approach to both diarrhea and malnutrition management, including oral rehydration, continuous feeding, zinc supplementation, and antibiotics for specific strains, it does not adequately address the complex needs of malnourished children with diarrhea who may benefit from enhanced care in the form of follow-up and monitoring beyond initial treatment. We aimed to …

The Journey And Lived Experience Of Dropout, Hispanic, Teen Fathers, Patricia Ann Cuevas

Open Access Theses & Dissertations

The dropout phenomenon in the United States is an ongoing concern, especially regarding teen fathers. The purpose of this qualitative phenological study was to examine how Hispanic men who fathered a child as adolescent understood and made sense of their lived experiences of dropping out of high school and later returning to their studies. Semi-structured interviews were utilized to gather the data. An analysis of the findings was conducted, revealing the themes of emotional distress, expectations, hard lessons, and the impact of fatherhood. The themes were then applied to the theorical framework of Sensemaking. The results revealed that the participants …

Critical Analysis Of Archival Data: The Alvarado V. Episd Case, Mauro Alfredo Hinojosa

Open Access Theses & Dissertations

This research analyses the Alvarado vs. El Paso Independent School District legal files, housed at the Sonnichsen Special Collections Department, The University of Texas at El Paso Library. This dissertation explored the following questions: Research question 1 (RQ1): What are the political and social-cultural contexts of the Alvarado case based on the Archives?; and Research Question 2 (RQ2): impact on school education, to include themes in policy and leadership. A qualitative research approach framed through Latino Critical Race Theory exposes how the U.S. education system has historically reinforced White perspectives and marginalized Latino groups, specifically focusing on Mexican-American students in …

Navigating Social And Academic Spaces As A Non-Traditional Student In A Doctoral Program: An Autoethnography, Luz Elena Nieto

Open Access Theses & Dissertations

This autoethnography examines my personal, professional, and academic experiences throughout my educational journey, aiming to address gaps in scholarly literature relevant to non-traditional students at all educational levels, particularly at the doctoral level. As a non-traditional student, I have encountered significant challenges during my academic career. I have often felt like an outsider due to my age, generational gap, and educational background. The impostor phenomenon has intensified my feelings of being an outcast, even though I have had a prosperous professional career. I have drawn upon my memories, reflections, narratives, scholarly literature, documents, and personal artifacts to provide a comprehensive …

Investigating A Study Abroad Program As A Reflective Development Of Intercultural Competence For Students In A Hispanic-Serving University, Akindele Ogunleye

Open Access Theses & Dissertations

This dissertation project investigates the broad problem of evaluation and effectiveness that have diminished the opportunities that study abroad can potentially offer as part of higher education in the U.S. The research aim was to develop a reflective plan of implementing study abroad to achieve the transformation of intercultural competence of students of higher education in a Hispanic university. The research questions were deduced from a combination of views from literature since the 1920s affirming study abroad as elitist endeavor, female, liberal arts and academically weak. Using a quantitative data methodology, the study were collected data from students who participated …

Understanding The Factors Associated With The Targeting Of Prison Gangs By Specialized Gang Units (Sgus) In The United States, Bruno Aldair Zapata

Open Access Theses & Dissertations

Specialized gang units (SGUs) are prominent in police departments in the United States with their sole purpose to respond to gang activity across the country. SGUs vary in the types of gangs they target, resources available, officer composition, and the types of enforcement activities they use. SGUs have encountered various controversies such as exaggerating the gang problem in the media, for distorted intelligence in their gang databases, and for racial stereotyping and harassment among Hispanics in particular. Research regarding SGUs is limited in general, but even fewer studies exist on the targeting efforts of prison gangs by SGUs. Prison gang …

First Latter-Day Saint Women Baptized In Europe And Oceania: Ann Cottam Dawson (1785-1849) And Terii (Ca. 1800-Ca. 1860), Robyn Shahan Spears

Graduate Theses and Dissertations

This dissertation is a study in the backgrounds, Latter-day Saint conversions, and ministries of two early nineteenth-century women: Ann Cottam Dawson in Lancashire, England and a woman known simply as Terii on the island of Tubuai in the Austral Islands (now French Polynesia). Because these two women did not leave behind diaries, this study relies upon evidence such as missionary diaries, newspapers, church records, vital records, genealogical records, sermons, and even a mutiny narrative. The discussion is organized in three parts: Dawson’s biography, Terii’s biography, and a comparison of the two. Both women fed and housed the missionaries, performed women’s …

The Inclusion Of Soybean Co-Products In Ruminant Supplements On Health And Reproductive Efficiency, Kirsten Midkiff

Graduate Theses and Dissertations

Soybeans are a vital commodity for Arkansas and the United States, with co-products such as soybean meal having wide popularity in animal feeds due to high protein content and palatability. Soybean meal primarily is utilized in diets for swine and poultry operations with a small market in the beef cattle industry, likely due to the increased costs that are associated with the product. On the other hand, soybean oil is a product from the production of soybean meal that is not as widely used in the livestock industry as most of the oil produced is used for industrial purposes. Additionally, …

The Role Of Dynastic Marriage In The Reigns Of Mary I And Elizabeth I Of England, Regan Vann

Graduate Theses and Dissertations

My project will cover the role gender and dynastic marriage played in the reigns of Mary I of England Elizabeth I of England, and the differences they caused in their reigns compared to a reign of a male monarch. The historical question I am exploring is how Mary and Elizabeth’s gender impacted their reign by means of dynastic marriage. Marriage was important for the English royals as the prospect of marrying foreign royal created opportunities for alliances with other realms. Royal marriages were often arranged by the monarch, usually a king, for his children, especially his female children. Mary and …

Ang “Sublime” Ayon Sa Mga Taga-Tayabas, Fernando Nakpil-Zialcita

Katipunan

Isang paksang mahalaga ang “Sublime” sa kaisipang Kanluranin. Ano ang katumbas nito sa kaisipang Tagalog? Ayon sa mga eksperto, ang “maringal” ay wastong salin. Pero paano ginagamit ang maringal sa Tagalog? Paano ito naiiba sa dalawang magkalapit na salitang “maganda” at “dakila”? Itong sanaysay ay isang imbestigasyong antropolohiko tungkol sa pag-unawa ng mga mamamayan sa bayan ng Tayabas, Quezon, sa isang ekspresyong pilosopiko. Nanirahan ang awtor nang ilang linggo sa Tayabas. Gumamit siya ng participant observation at key informant interview sa pananaliksik. Namili ng mga respondent sa dalawang sektor: 1) taga-nayon, at 2) taga-sentro. Sa bawat panayam, tinanong sa mga …

Ang Iba’T Ibang Anyo Ng Buwan: Paggunita Sa Kasaysayan Ng Dulang Mula Sa Buwan Batay Sa Ebolusyon Ng Panghuling Eksena At Salita, Pat Valera

Katipunan

Ang dulang Mula sa Buwan ay makailang ulit nang ipinalabas sa loob ng labinlimang taon nitong kasaysayan. Simula pa noong 2010, nagkaroon na ng tatlong mahahalagang pagbabago ang teksto ng dula. Sa papel na to, inilalahad ng manunulat, na siya ring mandudula, ang mga nangyaring pagbabago partikular na sa panghuling eksena at salita ng dula. Sa pag-alala sa pinagdaanan ng dula, makikita kung papaanong, dahil sa danas ng mandudula at sa nagbabagong panahon at lipunan, humantong ang dula sa kasalukuyan nitong bersiyon.

Ganap: Ang Paikid Na Katuparan Ng Igualidad, Glecy C. Atienza

Katipunan

Tinatalunton ng pag-aaral ang diskurso ng ganap bilang tala, tanda at tatak ng makilos na pag-iral ng mga dramatikong salaysay. Gamit ang mga tekstong pabigkas hanggang sa nakatalang anyo ng mga pagtatanghal, inuusisa ng pag-aaral ang talab ng nagbabagong sistema ng pag-iral at paglikha ng mga dramatikong anyo na oral at nakalimbag bilang batis ng pagkilala sa tampok na ganap sa pag-unlad ng dula at pagtatanghal na lokal.

Paloob At Palabas Ng Ateneo Entablado: Pag-Uugat Ng Ateneo Entabladosa Tradisyong Pantanghalan At Sosyo-Politikal Ng Ateneo De Manila, Jerome D. Ignacio

Katipunan

Ang Ateneo ENTABLADO ay isa sa tatlong pangkat panteatro ng Pamantasang Ateneo de Manila. Tinatangi ng ENTABLADO ang sarili sa pamamagitan ng pagpapakilala sa sarili nito bilang sosyo-politikal na pangkat panteatro. Nais siyasatin ng pag-aaral kung paano umusbong at sumulong ang isang sosyo-politikal na pangkat panteatro sa loob ng isang paaralang eksklusibo. Nilalayon ng pag-aaral samakatwid na taluntunin ang tradisyong pantanghalan at sosyo-politikal ng Ateneo ENTABLADO. Iuugat ito ng pag-aaral sa mayamang tradisyong pantanghalan at sosyo-politikal ng mismong institusyong kinabibilangan nito, ang Pamantasang Ateneo de Manila. Gagamitin ng pag-aaral bilang konseptuwal na balangkas ang diskurso ng (pa)loob at (pa)labas upang …

Roger Williams University 2024 President's Report: A Message From President Miaoulis, Roger Williams University

Life of the Law School (1993- )

No abstract provided.

Miscarriages Of Justice In Immigration Detention, Louis Century, Kent Roach

UBC Law Review

No abstract provided.

The Impact Of Father-Daughter Relationships On Dating And Relationship Behaviors For African American Women: A Qualitative Analysis, Neeah A. Lofton

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study examines how African American father-daughter relationships can impact their dating and relationship behaviors. This highlights an important role African American fathers play in shaping their daughter’s development and expectations within romantic relationships. The purpose of this qualitative (grounded theory) study was created to unravel the unique dynamics that shapes African American women's views on intimacy, self worth and relationships expectations. The research seeks to fill existing gaps in literature, moving beyond the notion of African American father presence to explore the emotional context that influences their daughter’s romantic lives. The research question for this study is for African …

Things My Mother And I Don’T T Alk About, Hannah Fuller

Gandy Dancer Archives

No abstract provided.

Grant Writing: The Essentials, Jayme Renfro

Faculty Book Gallery

Welcome to the exciting and impactful world of grant writing! Whether you are a student embarking on a career in nonprofit management, a budding researcher eager to secure funding for your projects, or a professional looking to hone your grant writing skills, this textbook is designed to guide you through every step of the grant writing process. Grant writing is not just about securing funds; it's about crafting a story, building relationships, and making a tangible impact on communities and fields of study. This book aims to equip you with the knowledge, skills, and insights needed to excel in this …

Intensive Postpartum Antihypertensive Treatment (Ipat) And Healthy Lifestyle Education: Study Protocol For A Pilot Randomized Controlled Trial For Patients With Hypertensive Disorders Of Pregnancy, Anna Palatnik, Nadine Sunji, Zaira Peterson, Jennifer M. Ohlendorf, Amy Y. Pan, Jacquelyn Kulinski

College of Nursing Faculty Research and Publications

Background

Hypertensive disorders of pregnancy (HDP) complicate about 10% of pregnancies and lead to postpartum hospital readmissions and cardiovascular complications. Following HDP, vascular dysfunction could persist and accelerate the trajectory of cardiovascular disease risk. The benefits of intensive blood pressure (BP) control following HDP have not been adequately investigated. Therefore, no standard guidelines exist to guide the management of mild-to-moderate hypertension in the postpartum period, leading to a wide variation in clinical practice. The present study will investigate the effect of intensive BP control and healthy lifestyle education on maternal cardiovascular health (CVH) and vascular function following HDP.

Methods

The …

African American Males In Rural Elementary Schools During The Pandemic: Experiences, Challenges, And Strategies For Success, Jessica Lewis

All Dissertations

The present study experimentally examined the impact of the COVID-19 pandemic on elementary African American males living in rural areas. The qualitative study used a phenomenological approach to examine students' perspectives, as understood by the parents and educators (N=10). Using semi-structured interviews and thematic coding, the researcher suggested strategies for successfully closing instructional gaps and meeting the needs of this population moving forward.

The theoretical frameworks that triggered this exploration were Intersectionality, Maslow’s Hierarchy of Needs, and Conflict Theory. The researcher used the theories as a lens to answer the following research questions: (1) How much has COVID-19 revealed the …

Psychophysical And Functional Outcomes In Chemotherapy-Induced Peripheral Neuropathy After Spinal Cord Stimulation: A Narrative Review And Case Series, Peter D Vu, Kathleen Erin Mcdonough, Patrick M Dougherty, Ryan S D'Souza, Saba Javed

Faculty, Staff and Student Publications

Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) is a complication that may occur after treatment with various anticancer drugs. In refractory CIPN cases, spinal cord stimulation (SCS) has garnered increased attention. The use of gait analysis and psychophysical quantitative sensory testing (QST) as an objective measurement of CIPN-related damage has burgeoned; however, these changes have not been reported for patients with CIPN after SCS implantation using either burst or tonic stimulation.

Materials and methods: This manuscript encompasses two parts: 1) a presentation of pain improvement in a series of patients who underwent tonic vs burst SCS for CIPN measured by gait and …

Artificial Intelligence And Machine Learning In Cancer Pain: A Systematic Review, Vivian Salama, Brandon Godinich, Yimin Geng, Laia Humbert-Vidan, Laura Maule, Kareem A Wahid, Mohamed A Naser, Renjie He, Abdallah S R Mohamed, Clifton D Fuller, Amy C Moreno

Faculty, Staff and Student Publications

Background/objectives: Pain is a challenging multifaceted symptom reported by most cancer patients. This systematic review aims to explore applications of artificial intelligence/machine learning (AI/ML) in predicting pain-related outcomes and pain management in cancer.

Methods: A comprehensive search of Ovid MEDLINE, EMBASE and Web of Science databases was conducted using terms: "Cancer," "Pain," "Pain Management," "Analgesics," "Artificial Intelligence," "Machine Learning," and "Neural Networks" published up to September 7, 2023. AI/ML models, their validation and performance were summarized. Quality assessment was conducted using PROBAST risk-of-bias andadherence to TRIPOD guidelines.

Results: Forty four studies from 2006 to 2023 were included. Nineteen studies used …

Mortality Risks Associated With Depression In Men With Prostate Cancer, Casey Crump, Pär Stattin, James D Brooks, Jan Sundquist, Weiva Sieh, Kristina Sundquist

Faculty, Staff and Student Publications

Background: Men diagnosed with prostate cancer (PC) have an increased risk of depression; however, it is unclear to what extent depression affects long-term survival. A better understanding of such effects is needed to improve long-term care and outcomes for men with PC.

Objective: To determine the associations between major depression and mortality in a national cohort of men with PC.

Design, setting, and participants: A national cohort study was conducted of all 180 189 men diagnosed with PC in Sweden during 1998-2017. Subsequent diagnoses of major depression were ascertained from nationwide outpatient and inpatient records through 2018.

Outcome measurements and …

Healthcare Disparities, Screening, And Molecular Testing In The Changing Landscape Of Non-Small Cell Lung Cancer In The United States: A Review, Razelle Kurzrock, Aadel A Chaudhuri, David Feller-Kopman, Narjust Florez, Jed Gorden, Ignacio I Wistuba

Faculty, Staff and Student Publications

Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describes healthcare disparities in the changing landscape of non-small cell lung cancer (NSCLC) in the United States, focusing on racial, ethnic, sex-based, and socioeconomic trends. Furthermore, strategies to address disparities, overcome challenges, and improve patient outcomes are proposed. Barriers exist across lung cancer screening, diagnosis, and treatment regimens, varying by sex, age, race and ethnicity, geography, and socioeconomic status. Incidence and mortality rates of lung cancer are higher among Black men than White men, and incidences in young women are substantially greater than …

Keratinocyte Carcinomas In Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study, Christina Boull, Yan Chen, Cindy Im, Alan Geller, Yadav Sapkota, James E Bates, Rebecca Howell, Michael A Arnold, Miriam Conces, Louis S Constine, Leslie Robison, Yutaka Yasui, Gregory T Armstrong, Joseph P Neglia, Lucie M Turcotte

Faculty, Staff and Student Publications

Background: Childhood cancer survivors (CCS) are at increased risk for keratinocyte carcinomas (KC) however, the long-term incidence of single and multiple KC is not well established.

Objective: Identify risk factors and quantify KC cumulative incidence and multiple-incidence burden in CCS.

Methods: KC were identified among Childhood Cancer Survivor Study participants, a cohort of 5-year cancer survivors diagnosed < 21 years of age between 1970 and 1999 in North America. Cumulative incidence was estimated and multivariable models assessed relative rates of KC associated with survivor and treatment characteristics.

Results: Among 25,658 participants, 1446 developed 5363 KC (93.5% basal cell carcinoma, 6.7% squamous cell carcinoma; mean age 37.0 years (range 7.3-67.4), mean latency 25.7 years; 95.3% White and 88.4% with radiotherapy). Mean lesion count was 3.7 with 26.1% experiencing ≥4. Radiotherapy imparted …

Radiation-Induced Macrovessel/Microvessel Disease, Jun-Ichi Abe, Bryan G Allen, Andreas M Beyer, David Lewandowski, Kranti A Mapuskar, Vikram Subramanian, Michelle R Tamplin, Isabella M Grumbach

Faculty, Staff and Student Publications

Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers. Moreover, radiation at various sites can lead to peripheral vascular disease. An aspect of radiation-induced injury that has received little attention is microvascular injury, which typically results from …

Development Of Novel Ionization Chambers For Reference Dosimetry In Electron Flash Radiotherapy, Kevin Liu, Shannon Holmes, Ahtesham Ullah Khan, Brian Hooten, Larry Dewerd, Emil Schüler, Sam Beddar

Faculty, Staff and Student Publications

Background: Reference dosimetry in ultra-high dose rate (UHDR) beamlines is significantly hindered by limitations in conventional ionization chamber design. In particular, conventional chambers suffer from severe charge collection efficiency (CCE) degradation in high dose per pulse (DPP) beams.

Purpose: The aim of this study was to optimize the design and performance of parallel plate ion chambers for use in UHDR dosimetry applications, and evaluate their potential as reference class chambers for calibration purposes. Three chamber designs were produced to determine the influence of the ion chamber response on electrode separation, field strength, and collection volume on the ion chamber response …