Digital Commons Network^™

Using Multiplexed Functional Data To Reduce Variant Classification Inequities In Underrepresented Populations, Moez Dawood, Shawn Fayer, Sriram Pendyala, Mason Post, Divya Kalra, Karynne Patterson, Eric Venner, Lara A Muffley, Douglas M Fowler, Alan F Rubin, Jennifer E Posey, Sharon E Plon, James R Lupski, Richard A Gibbs, Lea M Starita, Carla Daniela Robles-Espinoza, Willow Coyote-Maestas, Irene Gallego Romero

Faculty, Staff and Students Publications

BACKGROUND: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).

METHODS: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database. Then, we incorporated clinically calibrated MAVE data into the Clinical Genome Resource's Variant Curation Expert Panel rules to automate VUS reclassification for BRCA1, TP53, and PTEN.

RESULTS: Using two orthogonal statistical approaches, we …

Arousal Effects On Oscillatory Dynamics In The Non-Human Primate Brain, Shashank A Anand, Fatih Sogukpinar, Ilya E Monosov

2020-Current year OA Pubs

Arousal states are thought to influence many aspects of cognition and behavior by broadly modulating neural activity. Many studies have observed arousal-related modulations of alpha (~8 to 15 Hz) and gamma (~30 to 50 Hz) power and coherence in local field potentials across relatively small groups of brain regions. However, the global pattern of arousal-related oscillatory modulation in local field potentials is yet to be fully elucidated. We simultaneously recorded local field potentials in numerous cortical and subcortical regions in the primate brain and assessed oscillatory activity and inter-regional coherence associated with arousal state. In high arousal states, we found …

Particle Size And Settling Velocity Of Bed And Suspended Sediments For Mud-Sand Beds, Leo Van Rijn, Luitze Perk, Bas Van Maren, Andy Manning

School of Geography, Earth and Environmental Sciences

The particle size and the settling velocity of sediments are key parameters in sediment transport studies. However, it remains surprisingly difficult to determine particle size and settling velocity distribution of fine-grained sediments (mud-sand). A large range of methodologies exist to measure either the particle size distribution or to measure the settling velocity. An important influential parameter is the shape of fine-grained sediments, with clay minerals being shaped as plates rather than as spheres. Furthermore, the settling velocity of fine particles is influenced by turbulent shear and flocculation processes. Sometimes, the sediment samples are pre-treated (destroying inter-particle bonds) to measure the …

Correction: Nepali Oral Microbiomes Reflect A Gradient Of Lifestyles From Traditional To Industrialized, Erica P Ryu, Yoshina Gautam, Diana M Proctor, Dinesh Bhandari, Sarmila Tandukar, Meera Gupta, Guru Prasad Gautam, David A Relman, Ahmed A Shibl, Jeevan Bahadur Sherchand, Aashish R Jha, Emily R Davenport

Faculty, Staff and Student Publications

No abstract provided.

Solutions To Mitigate Information Security Breaches And Protect Personally Identifiable Information In A Public-Sector Cloud Computing Environment, Valerie Johneeda Rountree

Walden Dissertations and Doctoral Studies

Information is a significant asset to organizations because more organizations are moving data and applications to the cloud, so it is critical to ensure the protection of personally identifiable information (PII) stored in the cloud. The specific research problem was that information technology project managers (ITPM) lack a unified approach to protecting PII stored on the cloud. The purpose of this generic qualitative study was to understand how ITPMs may implement viable solutions to mitigate the frequent occurrences of information security breaches in a public cloud environment. The National Institute of Standards and Technology provided the conceptual framework for the …

First Nations' Enviornmental Protests, Robert Cooper Smitherman

Honors Capstone Projects and Theses

No abstract provided.

Oral History Casey Goodson, Brady Goodson

Oral Histories HIST 300, Fall 2024

Interview of pastor Casey Goodson by Brady Goodson. Discusses elementary education and teaching as well as the work of a pastor.

Teresa Rodriquez Academic History, David L. C'De Baca

Oral Histories HIST 300, Fall 2024

Oral History of Teresa's current academic achievements

Francesca C'De Baca Academic History, David L. C'De Baca

Oral Histories HIST 300, Fall 2024

Francesa C'de Baca current academic and extracurricular achievements as of December 2024.

Diplomacy Of Palestinian Civilizational Confrontation In Light Of A Changing World, Morsi Abdel Al Kareem Abdel Razeq

The World Research of Political Science Journal

This study aims to clarify the current changing global situation with its composition, complexities, details, daily crises, and its repercussions on the Palestinian issue, which requires Palestinian civilizational diplomacy to review the Palestinian struggle path, evaluate its performance and results, and review its work methods and strategies to deal with the dynamics of transformations and complex interactions, in a way that protects legitimate Palestinian rights. And it contributes to preserving the specificity of the Palestinian issue by preserving peace, peace and coexistence between religions, protecting cultural and religious property, and rejecting terrorism regardless of its perpetrators, in order to achieve …

Journal Of Response To Writing 10(2)

Journal of Response to Writing

No abstract provided.

Making Video Feedback For The First Time: A Case Study, Dan Martin

Journal of Response to Writing

This paper examines some of the labor three professors from three different disciplines needed to exert to produce effective VF on student writing for the first time. The research on VF demonstrates that students want more video comments but the labor to learn how to make VF has not been fully identified. I completed a case study with three professors to collect data. I interviewed the professors at the beginning, middle, and end of the study. After transcribing and coding the interviews, I identified where the professors exerted a significant amount of labor to make VF for the first time. …

Developing A Learner-Centered Response To Writing Through A Graduate Course In Writing-Across-The-Curriculum, Faqryza Ab Latif, Kristin Winet

Journal of Response to Writing

Although writing-across-the-curriculum (WAC) programs have been commonplace since the 1970s, the focus has largely been at the level of assessment and programmatic development and less on the instructors, particularly graduate teaching assistants (TAs) who adopt these practices. In this article, we describe a pilot WAC graduate-level course in writing pedagogy that our institution developed as part of our recent membership in the Center for the Integration of Research, Teaching, and Learning (CIRTL). We also share how one science, technology, engineering, and mathematics (STEM) graduate student revised her approach to assignment design, feedback, and assessment for a general education course and …

The Effects Of Dynamic Written Corrective Feedback On Efl University Students’ Writing Accuracy: A Complex Dynamic Systems Theory Perspective, Attila M. Wind

Journal of Response to Writing

The positive effects of dynamic written corrective feedback (DWCF) on linguistic accuracy are well-documented (Evans et al., 2010). However, studies on DWCF without exception have adopted a pretest-posttest research design; therefore, they were unable to explore the dynamics of development (Larsen-Freeman, 2006). In addition, all of the previous DWCF studies exclusively provided indirect feedback to students. Consequently, our knowledge is limited as to whether a modified version (providing direct feedback) of DWCF would be effective. To address this issue, in this study 24 university undergraduate students composed a total of 288 essays and received modified DWCF (direct feedback) on a …

Dr. Hatsuo Ishida: Using Macromolecules To Shape The World, Kayleigh Bauer

Discussions

No abstract provided.

Urinary Tract Infection Education And Prevention, Jodi Hernandez, Dylan Godfrey

DNP and Student Works

The purpose of providing education and training to staff with respect to educating patients greater than 65 years of age was to effectively improve staff and patients’ knowledge of preventing urinary tract infections (UTIs).

Theoretical Framework: The two theoretical frameworks utilized included Kotter Change Management Model and The Kurt Lewin’s change model. Both of these theorists supported the need for successful change to improve patient outcomes.

Incorporating Financial Literacy For College Students, Joelle Pretty

MAGIS: Student Development Journal

In light of the stalled economy and challenges to state and financial aid, it is imperative that students develop expertise in financial matters. Whether offered in the classroom or by student services, colleges and universities should be ensuring students receive this information. This paper looks at one department’s attempt to implement effective financial education programming.

Black Culture Foundation, Wilmer Amina Carter Foundation

Bridges Digital Archive: Audio and Video Recordings

Ratibu Jacocks interviews three members of the San Bernardino Black Culture Foundation, an organization that strives to uphold and preserve Black culture in the city of San Bernardino. The three members were Emil Latroy Ingram, Genevieve Echols, and Margaret Hill. The three discuss their backgrounds with Ingram as a member of the Ingram family and from Los Angeles, Hill from the west side of San Bernardino, and Hill from Virginia. Enchols mentioned that she was the president of the San Bernardino Black Culture Foundation. Hill was an executive producer. She explains that after settling in San Bernardino, she met many …

Integrating The Elementary Literacies Through The Practice Of Physical Education: A Strategy Resource, Bryan Matera, Dillon Martinez

Essays in Education

Integrating literacy and physical education (PE) supports interdisciplinary learning that engages both the mind and body. This article explores innovative approaches to combining literacy skills with physical activity, highlighting the cognitive and physical benefits for elementary students. Recognizing students’ natural attraction to movement, the article demonstrates how embedding literacy into PE lessons can enhance reading comprehension, vocabulary acquisition, and memory retention through action-oriented activities. These strategies also promote physical literacy, encouraging confidence and lifelong participation in physical activities.

Key instructional examples include the "Movement-Enhanced Word Wall," where students connect vocabulary to movement, and "Animal Action Reading Relays," which integrate reading …

Utah V. Strieff And Teaching Analysis, Lisa A. Tucker

St. John's Law Review

(Excerpt)

In Utah v. Strieff, the Supreme Court considered whether the Fourth Amendment required suppression of evidence obtained in an unlawful investigatory stop when police discovered that the person stopped was subject to lawful arrest based on an unrelated outstanding warrant. The majority opinion, written by Justice Clarence Thomas, held that suppression was not required in such a case; the dissent by Justice Sotomayor argued that it should be.

These two legal opinions took jarringly different approaches to determining a question of law, one that disproportionately impacts people of color, who are statistically most likely to be unlawfully stopped …

After The Age Of Discretion: Policing And Privacy In A World Of Automated Roadway Enforcement, Trayce Hockstad, Lawrence Cappello

St. John's Law Review

(Excerpt)

Our Fourth Amendment attempts to harmonize in fifty-eight words the tenuous, antagonistic relationship between privacy and public safety. These two values appear to be deadlocked in a contentious legal orbit, leaving behind them a trail of fascinating but foreboding jurisprudence in American law. The fundamental need of individuals for spaces of seclusion from government surveillance has endured a slow siphoning of its constitutional protection by the encroaching definition of the “public” and the perceived need to police every person and place that may be considered so. Nowhere has this proven truer than our nation’s roadways. As the judicial system …

Listening To Ghosts In The Appalachian Mountains: The Western North Carolina Tomorrow's Black Oral History Project As A Community Archive, Elizabeth Harper

Journal of Contemporary Archival Studies

This case study invites archivists to broaden our understanding of what constitutes a community archive using the Western North Carolina Tomorrow Black Oral History Project as its focus. The oral history project captured the experiences of Black elders in Western North Carolina in the 1980s and provides a unique insight into a Black community in the Southern Appalachian Mountains. The leaders and participants wanted this project to increase Black representation in Appalachian history and intended the materials be distributed widely. However, university staff kept the collection closed for almost forty years, and it was only opened in 2018. Fitting definitions, …

Towards New Forms Of Using Social Media: Museums Activity On Linkedin, Magdalena Sawczuk

Journal of Marketing and Consumer Behaviour in Emerging Markets

The social media landscape changes very fast. It regards, among others, the accessible platforms and the features of social media tools. It also concerns the broad spectrum of institutions that start their virtual activity in different ways, and museums’ participation in social media can be indicated here. Their activity mainly focuses on communication with the audience or other museums, but some new approaches can also be observed. One of them is activity on LinkedIn, which is closely connected to the professional perspective and employee-related issues. Hence, the article aims to explore the main paths and forms of the Polish museum’s …

Venality: A Strangely Practical History Of Unremovable Offices And Limited Executive Power, Jed Handelsman Shugerman

Notre Dame Law Review

The Roberts Court has asserted that Article II’s “executive power” implied an “indefeasible” or unconditional presidential removal power. In response to counterevidence from the Founding era, unitary executive theorists have claimed a “British Backdrop” of a general removal power under the English Crown and European “executive power.” These assumptions are incorrect.

This Article shows that many powerful executive officers through the late eighteenth century, especially high English Treasury offices and even “department heads” in the cabinet, were unremovable. A long common law tradition protected many English offices as freehold property rights. Moreover, this Article explains why it was widely understood …

Evaluation Of An Instructional Sequence To Promote The Emergence Of Convergent Intraverbals In Children With Autism, Jesika Woodard

Theses

Skinner (1957) defined intraverbal as a type of verbal behavior in which the

response form has no point-to-point correspondence with its verbal stimulus and is

followed by generalized conditioned reinforcement. Verbal behavior can be influenced

by multiple controlling variables, with convergent and divergent control being two

distinct types of this influence. In convergent intraverbals, multiple components of

antecedent verbal stimuli control a specific verbal response of the speaker. An example of

an intraverbal response under convergent control may be "banana" when asked, "What is

a fruit that is yellow?" De Souza et al. (2019) evaluated the effects of teaching …

Ad Hoc Constructions Of Penal Statutes, Joel S. Johnson

Notre Dame Law Review

The Supreme Court construed penal statutes in forty-three cases from the 2013 Term through the 2022 Term. In those cases, the Court tended to adopt narrow constructions, a preference consistent with several substantive canons of construction, such as the rule of lenity and the avoidance of constitutional vagueness concerns. Substantive canons were routinely included in party briefs, frequently raised during oral argument, and occasionally explicated in concurring opinions. Yet the Court did not rely on substantive canons in the vast majority of the narrow-construction cases. For example, the Court never firmly relied upon the rule of lenity—the substantive canon most …

Lanthorn, Vol. 59, No. 08, December 2, 2024, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

2024 December 02 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

A Machine Learning Approach To Predicting On-Time Graduation In Indonesian Higher Education, Mahendra Astu Sanggha Pawitra, Hui-Chun Hung, Handaru Jati

Elinvo (Electronics, Informatics, and Vocational Education)

Graduating on schedule is a critical milestone for students in higher education, serving as a key indicator of both institutional effectiveness and student success. This study uses machine learning techniques to predict on-time graduation in Indonesian higher education. A dataset comprising 133 students from an engineering department over four academic years (2019–2023) was analyzed using the CRISP-DM framework. The research employed nine machine learning models, including Random Forest, Logistic Regression, Neural Networks, etc., to identify key predictors of on-time graduation. The result showed that Random Forest outperformed other models by achieving an accuracy of 85% and an AUC of 0.875. …

Advances In Hyperspectral Remote Sensing For Precision Fertilization Decision-Making: A Comprehensive Overview, Jing Nie, Ke Wu, Yang Li, Jingbin Li, Bohan Hou

Turkish Journal of Agriculture and Forestry

With the rapid development of Internet of Things (IOT), big data analysis, artificial intelligence and other technologies, precision agriculture is receiving more and more attention and emphasis worldwide. Precision agriculture (PA), also known as fine agriculture and precision agriculture, refers to an agricultural method that obtains spatial and temporal variability information on crop yields and environmental factors (e.g., soil structure, topography, plant nutrients, water content, pests and diseases, etc.) in farm plots through high-tech to achieve positioning, timing, and quantification of the implementation of modern farming operation techniques and management.And fertilizer application plays an indispensable role in agricultural production. Reasonable …