Digital Commons Network^™

5-Substituted Flavones—Another Class Of Potent Triplex Dna-Specific Ligands As Antigene Enhancers, Landy Gu, Nghia Tran, Vanessa M. Rangel, Mandeep Singh, Krege M. Christison, Geoff P. Lin-Cereghino, Liang Xue

Pacific Faculty Work

In the field of drug development, the quest for novel compounds that bind to DNA with high affinity and specificity never ends. In the present work, we report the newest development in this field, namely, triplex DNA-specific binding ligands based on the 5-substituted flavone scaffold in our lab. Biophysical studies showed that the newly synthesized flavone derivatives (depending on the side chains) bind to triplex DNA with binding affinities better than or similar to 5-substituted 3,3′,4′,7-tetramethoxyflavonoids. These compounds selectively stabilize triplex DNA while having little effect on duplex DNA, as verified by various biophysical methods. A detailed structural analysis suggested …

Book Review: Great Power Clashes Along The Maritime Silk Road: Lessons From History To Shape Current Strategy, Patrick C. Bratton

Parameters Bookshelf – Online Book Reviews

Author: Grant F. Rhode

Reviewed by Dr. Patrick C. Bratton, professor of national security and strategy studies and director of South Asian studies, US Army War College

Dr. Patrick C. Bratton, US Army War College director of South Asian Studies, reviews Grant F. Rhode’s “valuable contribution to [the] literature” that “[brings] attention to many of Eurasia’s often-forgotten maritime powers and conflicts.” Bratton highlights the particular value of Rhode’s “excellent” case studies “that deserve attention” and explains the book’s utility for policymakers while also providing a thoughtful critique of the book’s framing devices.

Usa V. Jose Estrada

2024 Decisions

USDC for the Eastern District of Pennsylvania

Predictive Modeling And Sustainability Assessment Of Hydrothermal Liquefaction Of Seaweeds: A Techno-Economic And Life Cycle Analysis Approach, Micheal O. Asama

Mechanical Engineering Theses

This study presents comprehensive predictive models and an economic and environmental assessment of HTL for converting macroalgae into biofuels and valuable co-products. Predictive models were developed based on experimental kinetic data to simulate batch HTL of brown seaweed, capturing the yields of biocrude, gas, biochar, and water-soluble compounds as functions of key process variables, including temperature, time, pressure, and water-to-biomass ratio. Analysis of Variance (ANOVA) confirmed that temperature and residence time significantly affect biocrude yield, with an optimal yield of 23% achieved at 283°C, 200 bar, 54 minutes, and a 10:1 water-to-biomass ratio. The model’s predictive accuracy was validated with …

​​Living With Parkinson’S During Covid-19: A Survey Of Parkinson’S Patients During Covid-19​, Sia Shaila Pilgaonkar

Undergraduate Theses

The COVID-19 pandemic has significantly impacted individuals with Parkinson's disease (PD), raising concerns about exacerbation of symptoms and vulnerability of the patients. This project first reviews existing literature on the interconnections between COVID-19 and PD, focusing on the physiological, psychological, and treatment-related challenges faced by patients. Then it analyzes survey data examining increased severity of COVID-19 in individuals with PD, alongside the literature researching potential mechanisms linking the two, such as inflammation and neurodegeneration. The survey’s key areas of focus included symptom management, treatment satisfaction, the impact of PD on daily living, and the impact of COVID-19 on motor and …

Preparing Clinic Staff Nurses To Implement A Newly Hired Rn Preceptorship, Eston Sumner White

Walden Dissertations and Doctoral Studies

Veterans Affairs (VA) and the Department of Defense Healthcare Facilities are among the largest collective of healthcare management systems in the United States. The VA facility in this study has a nurse residency program for new hires and new graduate nurses but lacks a stable cohort of nurse educators to facilitate integration into care for a veteran population and to mentor skills and critical thinking. The purpose of this project was to create a sustained cadre of preceptors for a robust Registered Nurse (RN) program that will prepare recently graduated nurses and new hires for the unique set of situations …

Math Education: A Comprehensive Guide To Teaching The Foundations, Claudia Jayne Staruch

Honors College Theses

This thesis investigates the critical need for strong foundational mathematics education for adults. More specifically, for incarcerated individuals who lack basic numeracy skills because of the systematic inequalities that they have faced, the need for a mathematics foundation is even higher. This work emphasizes a non-technological approach to teaching these basics through qualitative analysis, including teaching strategies and practical lessons, while recognizing the various barriers many learners face. This research serves as a guide for educators to use for how to sequence and pace lessons, address certain learning styles, and gain classroom engagement, comprehension, and long-term retention of the materials. …

December 2024 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council

Graduate Council Minutes

No abstract provided.

Gonadal Absence Of Pig-1: Exploration Of Pig-1 In The Gonad Of Caenorhabditis Elegans, Winston S. Bennah

Undergraduate Theses

Caenorhabditis elegans are model organisms frequently studied to better understand biological processes. They have short life spans and produce a large number of progeny. Additionally, many of their molecular development processes can be found in human, providing insight into cell death and cell fate. In this project, our research aims to create a triple mutant strain to test the importance of the pig-1 gene in the gonad of C. elegans. This strain carries the following alleles: ckb-3::degron; him-8; gfp::pig-1. The pig-1 gene has been previously studied in neuroblast cells in C. elegans and is required for …

Why Law "Beyond The State" Need Not Be A Threat To Democratic Values, Paul Schiff Berman

Buffalo Law Review

Discussions of “law beyond the state” almost inevitably run into objections from those who believe that sub- or supranational legal orders necessarily subvert local democratic governance. Self-proclaimed populists and others express concern that the “will of the people” will be unduly subjected to the dictates of “cosmopolitan elites”1 or local factions, or corporate capture. These objections range across the political spectrum. Those on the right tend to focus on concerns that transnational orders will impose human rights or immigration rules on a national polity, while those on the left worry about trade regimes that might impose local labor or environmental …

Wmu Board Of Trustees Formal Session December 12, 2024, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Acceptance of the Agenda

Approval of the Minutes (September 26, 2024 and October 16, 2024 Meetings)

Remarks by the Chair of the Board

Remarks by the President

Updates by the Faculty Senate President

Updates by the Western Student Association President

Updates by the Graduate Student Association President

Presentation: Advancing EV Technology through Education

Public Comments Regarding Action Items

Action Items

Policy and Procedures for Periodic Assessment of the University President

Presidential Assessment

Consent Item

A. Personnel Report

B. Curriculum Proposals

C. Commercial Lease Agreement - 603 Ransom, Kalamazoo, MI

D. Natural Gas Pipeline Easement at West Hills

E. Membership Change …

Performance Evaluation Of Routing Protocols And Ml-Based Enhancements For Uav-Assisted Post-Disaster Communication Networks, Prachi Choudhary

Doctoral Dissertations and Master's Theses

During natural disasters, the existing communication systems collapse, and the disaster-affected areas become disconnected without any means of exchanging information. The collapse of existing communication networks poses challenges for First-Responders (FRs) in locating survivors during Search and Rescue (SAR) operations and for survivors to communicate for emergency aid. To alleviate post-disaster consequences and save lives, Uncrewed Air Vehicles (UAVs), commonly known as drones, can be employed to establish adaptable and reliable emergency communication networks. UAVs offer portability and rapid deployment, making them effective in crises. This thesis presents two main contributions: 1) Evaluation and Comparison of Routing Protocol Performance: The …

Synthesis Of Glycan Antigens For Therapeutic Antibodies And Glycoconjugate Vaccines, Synthesis Of An Inflammatory Pentasaccharide, And Design And Synthesis Of Ceragenins For Use In Medical Devices And Osteomyelitis, Shawn Gubler

Theses and Dissertations

A promising approach in combatting infections from antibiotic resistant bacteria/fungi is using therapeutic monoclonal antibodies (mAbs) that can bind the outer surfaces of microbes. We have developed a synthetic vaccine platform that can rapidly generate mAbs against surface glycans from desired strains, such as lipopolysaccharides and capsular polysaccharides. To create therapeutic antibodies against Ruminococcus gnavus, Burkholderia multivorans, and Staphylococcus aureus, we synthesize glycan antigens from each strain that are necessary for use in our glycoconjugate vaccine platform. Blooms of the Gram-positive bacterium Ruminococcus gnavus have been correlated with inflammatory bowel disease, and recently a polysaccharide produced by this organism was …

On The Readership Of Spinoza’S Writing & A Poetics For Thought, Tam Pham

Honors Thesis

This paper invites attention to textual facts and other intricacies in the readership of Spinoza’s writing, which bring to the fore his thinking qua thinking under language, a consideration that seems at least underappreciated, if not misappreciated, by the very readership in question. In so doing, the paper reflects on the possibility—and perhaps necessity—of a poetological purview into a philosophical corpus, in terms of its being written under a sense of Latin as well as of other tongues, generated by and for a thinker to be the linguisticity within which he thinks. To put in differently: if Spinoza were to …

December 12, 2024, The Dakota Student

The Dakota Student

No abstract provided.

Tuning Of The Structural And Electrical Properties Of Thermo-Luminescent Tungsten-Doped Indium Oxide Thin Film, C. Aparna, Pramoda Kumara Shetty, M. G. Mahesha

Open Access archive

This paper aims to synthesize tungsten-doped indium oxide thin film and to study its properties. Films with different tungsten dopant concentrations were deposited using the technique of spray pyrolysis. Raman spectroscopy and X-ray diffraction were used to investigate the structural features. It confirms the polycrystalline cubic structure of W-doped indium oxide. The morphological change observed with doping supports the preferred plane orientation change. Optical properties were studied using UV-visible spectroscopy. The photoluminescence spectra showed both near-band emission (NBE) and violet-blue emission. The suitability of the material for gamma sensing applications was confirmed by thermoluminescence (TL) spectroscopy. The binding energy obtained …

Ge/Sige Quantum Wells: Material For The Post-Moore Era, Troy Alexander Hutchins-Delgado

Optical Science and Engineering ETDs

This dissertation demonstrates high-quality germanium quantum wells on a 200 mm silicon wafer platform, enabling novel device possibilities. Partnering with a commercial silicon-germanium epitaxy supplier, we obtained shallow, undoped germanium quantum wells with high-crystalline quality, confirmed through x-ray diffraction, secondary ion mass spectroscopy, high-resolution scanning transmission electron microscopy, and energy dispersive x-ray spectroscopy. Hall bar devices fabricated on single quantum wells revealed that surface preparation can tune transport properties while maintaining peak mobilities around 10⁵ cm²V⁻¹s⁻¹. Manganese-germanide spintronic contacts were integrated via solid-state reaction, with contact quality assessed through Schottky diodes, transfer length …

Hypoxia-Inducible Factor 3Α1'S Role In Promoting Iron Loading, Tumorigenesis, And Metastasis In Colorectal Cancer, Luke B. Villareal

Biomedical Sciences ETDs

The interplay between hypoxia and iron metabolism drives colorectal cancer (CRC) progression. This dissertation investigates hypoxia-inducible factor 3α1 (HIF-3α1), a protein linked to poor CRC outcomes, focusing on its roles in metastasis, epithelial-to-mesenchymal transition (EMT), and iron loading via transferrin receptor (TFRC). HIF-3α1 promotes CRC cell migration by upregulating zinc finger E-box binding homeobox 2 (ZEB2) and suppressing N-myc downstream-regulated gene 1 (NDRG1), while TFRC-mediated iron accumulation supports tumor growth and survival. Iron chelation reduced EMT markers, migration, and tumor growth, highlighting iron's critical role. Additionally, HIF-3α1-induced TFRC expression altered nucleotide synthesis enzymes carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase (CAD) and phosphoribosyl pyrophosphate …

The Mass Murder Epidemic Of The United States: Policy, Reflections, And The Way Through, Isaiah Johnson

Dissertations, Theses, and Projects

This work is an in-depth look at American culture and how the culture has shaped gun policies in the U.S. I also examine various policies that could be used to mitigate mass shootings in the United States, as well as some of the reasons these incidents have become so prevalent.

Matthew Barlow V. Raymond Hour : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Third Judicial District Court, Salt Lake County, Honorable Coral Sanchez, District Court No. 170900003

Benjamin S. Ruesch Tony G. Jones Travis Dunsmoor Jeannette Barney RUESCH & REEVE, PLLC Counsel for Appellee

Jeffrey T. Colemere (8527) COLEMERE GIBBS, PLLC Tamara J. Hauge (4334) SMART, SCHOFIELD, SHORTER PC Emily Adams (14937) THE APPELLATE GROUP Counsel for Appellant

Exploring The Accuracy Of Interferometric Quantum Measurements Under Conservation Laws, Nicolò Piccione, Maria Maffei, Andrew N. Jordan, Kater W. Murch, Alexia Auffèves

Mathematics, Physics, and Computer Science Faculty Articles and Research

A (target) quantum system is often measured through observations performed on a second (meter) system to which the target is coupled. In the presence of global conservation laws holding on the joint meter-target system, the Wigner-Araki-Yanase theorem and its generalizations predict a lower bound on the measurement’s error (Ozawa’s bound). While practically negligible for macroscopic meters, it becomes relevant for microscopic ones. Here, we propose a simple interferometric setup, arguably within reach of present technology, in which a flying particle (a microscopic quantum meter) is used to measure a qubit by interacting with it in one arm of the interferometer. …

The Cowl - V. 88 N. 10 - December 12, 2024

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 10 - December 12, 2024. 20 pages.

Closed Domain Question Answering With Language Models: Application Of Retrieval-Augmented Generation And Parameter Efficient Fine-Tuning In Healthcare, Aaron Cummings

Master's Theses

Dementia care presents significant challenges for informal caregivers, particularly in managing behavioral symptoms that affect over 90% of individuals with Alzheimer’s Disease and Related Dementias (ADRD) during the moderate-to-severe stages. These symptoms, including agitation, wandering, and repetitive activities, impose emotional and physical burdens on caregivers, often exacerbated by a lack of reliable, accessible, and personalized resources. Non-pharmacological interventions, while evidence-based, are underutilized due to knowledge gaps and the inefficiency of traditional training and information retrieval methods.

This research explores the adaptation of large language models (LLMs) to address these challenges by developing a framework for closed-domain Question Answering (QA) systems, …

An Integrative Review Of Trauma Informed Care With Pediatrics To Minimize Psychological Sequelae Post Discharge, Amber Lee, Courtney Heinzelman

Master's Projects

Each year, a significant number of children sustain injuries requiring hospitalization, and while many recover physically, some face long-term psychological challenges such as post-traumatic stress, anxiety, and depression. This integrative review focuses on adolescents aged 13–18 who have experienced accidental trauma, exploring how trauma-informed care (TIC) in nursing compares to traditional approaches in reducing psychological impacts after discharge. Research suggests that many young patients report mental health symptoms for months following traumatic events. Trauma-informed care prioritizes principles such as safety, trust, peer support, and empowerment, aiming to reduce emotional distress and promote recovery. This review examines the application of these …

Social Worker Experiences Providing Mental Health Therapy To Iowa Lgbtq+ Youth, Kathy Jochims

Walden Dissertations and Doctoral Studies

High rates of untreated mental health issues and suicidality among LGBTQ+ youth, exacerbated by isolation and rejection in rural areas, demonstrate an urgent necessity for preventive and responsive mental health care. However, access to these essential services remains limited in many rural areas. This study involved using a generic qualitative design to explore the experiences of social workers providing mental health therapy to LGBTQ+ youth in rural Iowa, and presence of cultural humility in social worker practices. The cultural humility theory was chosen as the theoretical framework. Semistructured interviews with 10 Iowa social workers were evaluated using thematic analysis. Study …

Safety, Immunogenicity, And Efficacy Of A Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever With Thrombocytopenia Syndrome Virus And Heartland Bandavirus, Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates

Animal, Dairy, and Veterinary Science Faculty Publications

Background: Severe fever with thrombocytopenia syndrome virus (STSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases. With a high case fatality ratio, SFTSV has been designated a high priority pathogen by the WHO and the NIAID. Despite this, there are currently no approved therapies or vaccines to treat or prevent SFTS. Vesicular stomatitis virus (VSV) represents an FDA-approved vaccine platform that has been considered for numerous viruses due to its low sero-prevalence in humans, ease in genetic manipulation, and promiscuity in incorporating foreign glycoproteins into its virions. Methods: In this study, we developed a …

Systemic Antibiotic Selection In Skin And Soft Tissue Infections, Shafira Anindya Purnawan, Windy Keumala Budianti, Sandra Widaty

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Antibiotics are used in daily practice. To properly select antibiotics, it is important to pay attention to the definitive diagnosis, class of antibiotic, dose, interval, route of administration, and exact duration of use.

Discussion: The World Health Organization (WHO) categorizes antibiotics into three groups: Access, Watch, and Reserve—known as the AWaRe classification—to help guide appropriate usage and combat antibiotic resistance. The Gyssens flowchart serves as a valuable tool for clinicians to qualitatively evaluate antibiotic utilization. In skin and soft tissue infections (SSTIs), treatment strategies are tailored according to the characteristics of the infection, including purulence, necrosis, and overall severity. …

Social Worker Experiences Providing Mental Health Therapy To Iowa Lgbtq+ Youth, Kathy Jochims

Walden Dissertations and Doctoral Studies

High rates of untreated mental health issues and suicidality among LGBTQ+ youth, exacerbated by isolation and rejection in rural areas, demonstrate an urgent necessity for preventive and responsive mental health care. However, access to these essential services remains limited in many rural areas. This study involved using a generic qualitative design to explore the experiences of social workers providing mental health therapy to LGBTQ+ youth in rural Iowa, and presence of cultural humility in social worker practices. The cultural humility theory was chosen as the theoretical framework. Semistructured interviews with 10 Iowa social workers were evaluated using thematic analysis. Study …

Special Education Teachers’ Perceptions Regarding The Inclusion Of Students With Learning Disabilities In Assistive Technology, George Edward Avent

Walden Dissertations and Doctoral Studies

Special education teachers do not always include assistive technology (AT) in instructional practices to promote the academic success of students with learning disabilities. The purpose of this study was to explore the reasons special education teachers only sometimes include the use of AT in instructional practices. The conceptual framework was observational learning theory, also known as social learning theory, which focuses on human learning patterns based on observations of other human beings. A basic qualitative design with open-ended, semistructured interviews was used. The participants included 12 special education teachers from the school study site. The research questions framed the study’s …

Design, Synthesis, And Nmr-Guided Characterization Of A Targeted Covalent Inhibitor-Like Molecule Against Ivyp1 From P. Aeruginosa, Samuel Taylor Moore

Master's Theses

Multi-drug resistance poses a serious threat to future generations and historical antibiotic pipelines; consequently, the medical and economic burdens associated with treating multidrug-resistant bacteria are substantiated. In this context, P. aeruginosa (PA) emerges as one of the most significant healthcare challenges, being a leading cause of resistance-associated mortality worldwide. Despite modern efforts to combat these poor outcomes, drug-resistant cases continue to rise, and the need for novel antibiotic treatment is apparent. To this end, we investigated relevant resistance mechanisms and past antibiotic targets within PA, and in doing so, we identified relationships between peptidoglycan biology and a periplasmic protein, Inhibitor …