Digital Commons Network^™

Evaluation Of Therapeutic Efficacy Of Aloe Rabaiensis Leaf Against Salmonella Gallinarum Challenged In Kuroiler Chicks In Arusha, Tanzania, Mwanaisha S. Mkangara

Tanzania Journal of Science

Salmonella gallinarum, a bacterium causing fowl typhoid in gallinaceous birds, poses significant economic challenges to the chicken industry in Tanzania. This study investigated the potential of Aloe rabaiensis in managing S. gallinarum in Kuroiler chicks. The clinical signs, viable cell count, live weight, heterophils, lymphocytes, and monocyte counts were evaluated using ninety-four chicks grouped into T1, T2, T3 (challenged with S. gallinarum), and T4 (unchallenged with S. gallinarum). The findings revealed no statistically significant differences between the treated and control groups (P > 0.05) in viable cell count, live weight, mortality rate, heterophils, lymphocytes, and monocyte counts. However, there were clinical …

Contextualizing The Sdgs In The Anthropocene: Case Study Of Mekong Women’S Adaptation To Hydropower Dams In Northern Thailand, Maya Dania

Asia-Pacific Social Science Review

Large dams are among the most massive infrastructures built in the Mekong River and provide water-energy generators in the Lower Mekong Basin (LMB). Nevertheless, the Mekong River’s current transformation using electricity utilizing hydropower technology has damaged the local ecosystem in the LMB with social and environmental effects. Drawing upon feminist posthumanism, this study argues that the ongoing hydropower dam constructions in the LMB reflect uneven development and exclusion for women and the more-than-human nature of Mekong biodiversity. With a case study of Mekong women’s adaptation to regional development projects, this study aims to contextualize SDGs in the global crisis of …

Co-Existence With Forest Fires: Linking Forest Fires Management To Education For Sustainable Development Goals From Slash And Burn Practice In Kyushu Region, Japan, Reni Juwitasari

Asia-Pacific Social Science Review

Forest fires are often attributed to human activity, particularly slash-and-burn practices, as well as climate change, which influences the frequency and severity of fires and has detrimental effects on both humans and the environment. In Japan, the practice known as yakitaha has seen a substantial decline in most areas of the nation after the Second World War, with the exception of the mountainous region of Kyushu. A case study conducted on Itsuki-mura in Kumamoto Prefecture and Shiiba-mura in Miyazaki Prefecture has attracted attention because the preservation and claim of this practice contribute to the potential achievement of Sustainable Development Goals …

Robust And Generalizable Representations In The Hippocampus, Hung-Tu Chen

Dartmouth College Ph.D Dissertations

An intelligent system must balance generalizing across similar experiences with maintaining the distinctiveness of each experience. This thesis explores how the hippocampus manages this balance through its neural representations to support adaptive behavior. In Chapter 1, I provide an overview of key hippocampal phenomena that contribute to this process, including remapping, splitter signal, and replay. In Chapter 2, I challenge the concept of random remapping by showing that it is possible to predict, better than chance, how a given experience will be encoded in the hippocampus across different subjects. This suggests that encoding of related experiences, which was previously thought …

Nitric Oxide Levels In Primary Hypertension Patients Receiving Wet Cupping Therapy, Nurhayani Nurhayani, Dwi Pudjanarko, Nurahmi Nurahmi, Misriyani Misriyani

Media Kesehatan Masyarakat Indonesia

Wet cupping has been shown in several studies to lower blood pressure in hypertensive patients. However, the mechanism of action remains unknown, limiting its use as a complementary non-pharmacological treatment. This study aims to examine the effect of wet cupping on systolic blood pressure, diastolic blood pressure, and nitric oxide levels in hypertensive patients. The study employed a quasi-experimental method with a pretest and post-test design, including a control group. The sample consisted of 40 individuals, they were diagnosed with primary grade I hypertension. The participants were divided into two groups (treatment and control). The intervention group received wet cupping …

Tcf4 As A Potential Prognostic Biomarker And An Anticancer Target In Gastric Cancer, Michael Chuong

All Publications

Background: Lymphoid enhancer-binding factor 1 (LEF1)/T cell factor (TCF) family members are key transcription factors in malignant tumors. In this study, the role of T cell factor 4 (TCF4) in the progression of gastric cancer (GC) cell migration and invasion was investigated.

Methods: Fifty-five pairs of GC tissues and adjacent non-tumor tissues were collected for evaluating the expression of LEF1/TCF family members, which were also evaluated by the Gene Expression Profiling Interactive Analysis (GEPIA) database, an online analysis platform based on The Cancer Genome Atlas and Genotype-Tissue Expression databases.

Results: Through GEPIA online analysis and our experimental specimens, we found …

A Bee’S-Eye View Of Landscape Change: Differences In Diet Of 2 Andrena Species (Hymenoptera: Andrenidae) Between 1943 And 2021, Clare Boyes, Jennifer K Rowntree, Emma Coulthard

School of Biological and Marine Sciences

Declines in pollinating insects have been linked to changes in land cover, affecting the availability of nesting sites and floral resources. Our study is the first analysis of changes in pollen load composition of 2 mining bees, Andrena barbilabris (Kirby) and Andrena flavipes (Panzer) (Hymenoptera: Andrenidae), at the same sites in central England, over 75 years. This provides a unique opportunity to remove spatial variation and review temporal changes in pollen diet within the context of landscape change. We analyzed modern-day pollen load composition for these species and compared it with historical data from the same sites. We then examined …

Opportunities For Helicobacter Pylori Eradication Beyond Conventional Antibiotics, Camilia Metadea Aji Savitri, Kartika Afrida Fauzia, Ricky Indra Alfaray, Hafeza Aftab, Ari Fahrial Syam, Masrul Lubis, Yoshio Yamaoka, Muhammad Miftahussurur

Faculty, Staff and Students Publications

Helicobacter pylori (H. pylori) is a bacterium known to be associated with a significant risk of gastric cancer in addition to chronic gastritis, peptic ulcer, and MALT lymphoma. Although only a small percentage of patients infected with H. pylori develop gastric cancer, Gastric cancer causes more than 750,000 deaths worldwide, with 90% of cases being caused by H. pylori. The eradication of this bacterium rests on multiple drug regimens as guided by various consensus. However, the efficacy of empirical therapy is decreasing due to antimicrobial resistance. In addition, biofilm formation complicates eradication. As the search for new antibiotics …

Impact Of Essential Genes On The Success Of Genome Editing Experiments Generating 3313 New Genetically Engineered Mouse Lines, Hillary Elrick, Kevin A Peterson, Brandon J Willis, Denise G Lanza, Elif F Acar, Edward J Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J Adams, Allan Bradley, Robert E Braun, Steve D Brown, Adam Caulder, Gemma F Codner, Francesco J Demayo, Mary E Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O Goodwin, Yann Hérault, Lauri G Lintott, K C Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin Mckerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R Seavitt, Radislav Sedlacek, William C Skarnes, Damien Smedley, Sara Wells, Jacqueline K White, Joshua A Wood, International Mouse Phenotyping Consortium, Stephen A Murray, Jason D Heaney, Lauryl M J Nutter

Faculty, Staff and Students Publications

The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for its increased capacity and flexibility to efficiently generate null alleles in the C57BL/6N strain. In addition to being a valuable novel and accessible research resource, the production of 3313 knockout mouse lines using comparable protocols provides a rich dataset to analyze experimental and biological variables affecting in vivo gene engineering with Cas9. Mouse line production has two critical steps - generation of founders with the desired allele and …

Impact Of Bypass Fat Supplementation On Milk Production And Weight Gain In Nili Ravi Buffaloes Under Southern Khyber Pakhtunkhwa's Geo-Climatic Conditions, Shahzeb Khan, Arsalan Khan, Asad Ullah, Abid Ullah, Amjad Ali, Safi Ullah, Imran Khan, Muhammad Yasir, Israr Ud Din, Atta Ur Rehman, Muhammad Rizwan, Jahangir Ali

Journal of Bioresource Management

This study was conducted to examine the effect of bypass fat supplementation on milk production, composition, and body weight gain in Nili Ravi Buffaloes living in the unique geo-climatic conditions of Southern Khyber Pakhtunkhwa. Twenty lactating Nili Ravi buffaloes were randomly assigned to control and bypass fat supplementation groups in randomized, controlled experiment. Over the course of three months, data were collected on milk yield, milk composition, and body weight while environmental factors were considered. The bypass fat group gained significantly more weight on average than the control (p0.05). Bypass fat supplementation can substantially increase milk production, milk fat content, …

Evaluation Of Cotton Advanced Lines/Varieties For Genetic Diversity And Correlation Studies Of Cotton Leaf Curl Virus Disease With Yield Contributing Traits In Cotton, Nouman Bilal, Wajid Nazeer, Abdul Latif Tipu, Shoaib Liaqat, Muhammad Sarwar, Ansar Ali, Khadim Hussain, Maria Basheer

Journal of Bioresource Management

Plant genetic diversity aids in the creation of new varieties that are more resistant to pests and unfavorable climatic conditions. In order to discover varied parents and assess their cross-performance, the current study was carried out. The findings showed a substantial positive connection (0.81) between green bolls, plant height (0.57), and open bolls, as well as a significant positive correlation (0.52) between open bolls. On the other hand, a highly significant negative connection was discovered between the number of open bolls (-0.59), number of green bolls (-0.72), plant height (-0.78), and major stem nodes (-0.70) for the cotton leaf curl …

Protective Effects Of Fagonia Tenuifolia Methanolic Extracts Against Hyperhomocysteinemia Produced By Methionine, By Repeal Of Oxidative Stress Markers In Mice, Mahdia Hemal, Sakina Zerizer, Zahia Kabouche, Rachid Rouabhi

Journal of Bioresource Management

Natural products were extracted from many Fagonia species, belongs to the Zygophyllaceae family. They are used currently as drugs, these elements act as free radical scavengers. There are lot of stimuli which is able to produce oxidative stress, including hyperhomocysteinemia. There is accumulated evidence that free radicals can attack biological molecules such as lipids, proteins, and DNA, and causes changes in their molecular pathways that supports the pathogenesis of numerous diseases. In this work, the protective effects of methanolic extracts from Fagonia tenuifolia on methionine induced hyperhomocysteinemia in mice, on oxidative stress and damages in the aorta were sought. For …

Ameliorations Of Olea Ferruginea Fruit Pulp Extract In Ccl4 Induced Testicular Pathology In Mice, Syeda Nadia Ahmad, Tasleem Ishaq, Muhammad Ali Kanwal, Iram Inayat, Usma Abdullah, Khawaja Raees Ahmad

Journal of Bioresource Management

In present study the testicular histo-ameliorations of wild olive (Olea ferruginea) fruit pulp extract (OFPE) against intra-gastric CCl₄ exposure in mice was investigated. Thirty male albino mice were allocated into three groups of ten each: 1) Vehicle control (Vc); 2) CCl₄ (C); and 3) CCl₄+ Olea ferruginea (COf). All groups, except the Vc, were administered CCl₄ (0.1mL of a 0.2mLkg⁻¹ solution) in corn oil. Over the subsequent five days, the COf group received 0.1mL of Olea ferruginea plant extract (OFPE) daily, while the Vc and CCl₄ groups were provided water in …

Brucellosis And Its Diagnostic Techniques In Animals: A Comprehensive Review, Muhammad Mohsen Rahimoon, Amjad Hussain Mirani, Jam Kashif Sahito, Abdul Latif Bhutto, Pervez Ahmed Khoso, Riaz Ahmed Laghari, Asmatullah Kaka, Muhammad Aqeel, Ghulam Rasool Rahimmon

Journal of Bioresource Management

Brucellosis is a highly zoonotic infection found in animals and human, it has a high death ratio and lifetime sterility rate. The rates of intra- and interspecific infections have dramatically increased in recent years as a result of inadequate management and scarce resources particularly in developing nations. In cattle, reduced milk yield and elevated body temperature are the primary indicators, whereas in humans, soaring fever, overall malaise, and arthritis are the hallmarks of late-term abortion. Despite the fact that this diseases in animals and humans found unclear clinically, it will leads towards the hindrance in diagnosing this infectious illness serologically, …

A Review On Potential For Organic Farming In Pakistan, Amir Raza, Shahzada Asif Ali, Haroon Shahzad

Journal of Bioresource Management

Intensive use of agrochemicals (fertilizers and pesticides) has enhanced crop productivity in Pakistan. This rise in productivity has been achieved at the cost of degradation of natural resources (land and water), and environmental pollution. The current situation demands a gradual transformation towards eco-friendly farming practices like organic farming to ensure the sustainability of the agriculture sector. This article presents our viewpoint on the potential benefits of organic farming, its role in mitigating the impact of climate change and the potential for adoption and promotion of organic farming in Pakistan. Organic farming seems to offer promising opportunities on account of its …

Maximizing Growth And Yield Of Black Seed (Nigella Sativa L) Through Optimized Phosphorus And Boron Levels, Abdul Qudoos Khan, Abdul Qadeer Khan, Hanif Ullah, Navid Iqbal, Muhammad Junaid, Imad Murad, Faridullah Mamozai, Romaisa Amin, Waleed Iqbal, Uzair Ahmed

Journal of Bioresource Management

Improper nutrient management cause yield reduction in black seed yield and quality. Therefore, a field trial was executed in the growing season 2022-23 at The University of Agriculture Peshawar to inspect the effects of different phosphorus (P) and boron (B) levels on black seed (Nigella sativa L.). The experiment used a randomized complete block design with a split-plot arrangement, replicated thrice. The study examined four P levels (0, 15, 30, and 45 kg/ha) and four B levels (0, 1, 2, and 3 mg/L) on various growth and yield parameters of black seed. Plots treated with 45 kg/ha of P …

A Comprehensive Study On One Health Strategy And Public Health Effects Of Salmonella, Muhammad Aqeel, Amjad Hussain Mirani, Parvez Ahmed Khoso, Jam Kashif Sahito, Riaz Ahmed Leghari, Abdul Latif Bhutto, Muhammad Mohsen Rahimoon, Abdul Azeem Khoso, Rasool Bux, Azmat Aliasn Arsalan Ali

Journal of Bioresource Management

Salmonella poses a significant public health challenge due to its antibiotic resistance, zoonotic transmission, and diverse clinical manifestations. Over 60 % of human diseases are zoonotic, influenced by ecological dynamics and human activities such as land use changes, population growth, and international travel. Foodborne diseases, particularly those caused by Salmonella spp., have a substantial global impact, especially in low-income countries. Salmonella is divided into two species, Salmonella enterica and Salmonella bongori, with more than 2000 serotypes and six subspecies within S. enterica. This bacterium is highly adaptable, surviving extreme conditions such as drying, high salt concentrations, and acidic …

Effect Of Curcuma Longa On Growth And Lipid Profile Of Broiler Chickens Across Seasons, Sehrish -, Roheela Yasmeen

Journal of Bioresource Management

The poultry sector plays a critical role in driving economic growth and meeting the protein needs of the population. Recently, natural additives like turmeric (Curcuma longa) have attracted attention for their antimicrobial properties and their potential to reduce the reliance on antibiotics in poultry feed. This study evaluated the effects of turmeric supplementation at varying concentrations on broiler chickens during winter and summer seasons. Over a 42-day period, 40 broilers were divided into four groups: Control, Experimental Group 1 (1% turmeric), Experimental Group 2 (1.5% turmeric), and Experimental Group 3 (2% turmeric). Vaccination against Newcastle Disease (ND) and …

A Review On Poultry; Semen Storage And Preservation, Zafar Ali Khoso, Nasir Rajput, Imdad Hussain Leghari, Asmatullah Kaka, Tarique Khokhar

Journal of Bioresource Management

For the improvement of genetic resources and their maintenance, new techniques of assisted reproductive technologies have been developed. Cryopreservation of semen, embryo transfer and artificial insemination in mammals are used, while in the avian technique of artificial insemination after semen cryopreservation is proved fruitful. By using this developed technique, the best fertility rate in chicken can be obtained by artificial insemination. In vitro cryopreservation can affect the motility, life of sperm, viability, fertilizing ability. From mammalian sperm cell, the avian sperm cell is different in shape, size having polyunsaturated fatty acid. The use of suitable cryo-protectants and semen extender can …

The Impact Of Model Pose On Consumer Perceptions Of Price: A Perceived-Power Perspective, Jeonggyu Lee, Dong Hoo Kim

Asia Marketing Journal

This study examines how a model's pose that signals power influences consumers' recall ability of price information in advertisements. To extend prior findings on social judgments, we suggest that the direction of consumers' gaze and willingness to pay attention to the model vary depending on the model's pose. Study 1 explores how consumers' perception of the power of the model affects their price recall ability. In particular, consumers demonstrate better price recall for items displayed at the bottom of the ad when the model adopts a powerful pose and items displayed at the top when the model in the ad …

Fallen Kingdoms And Ancient Monoliths: The Influence Of Atlantis And Egypt In Tolkien’S Númenor, Charlotte J. Brockway

Journal of Tolkien Research

In light of the recent publication of The Fall of Númenor, my essay aims to focus on Tolkien’s, somewhat underappreciated, influences on Gondor; particularly Ancient Egypt. This essay looks at Plato's Timaeus and Critias, Ignatius Donnelly's theories, and examines the Atlantean and Egyptian motifs in Tolkien’s version of Westernesse, in particular, the remnants of Atlantean civilization survived by Egyptian colonists which mirror the Realms of Exile (Gondor and Arnor).

Negative Effect Of Treatment With Mglur5 Negative Allosteric Modulator Afq056 On Blood Biomarkers In Young Individuals With Fragile X Syndrome, Dragana Protic, Stephanie Morris, Et Al.

2020-Current year OA Pubs

BACKGROUND: Fragile X syndrome, with an approximate incidence rate of 1 in 4000 males to 1 in 8000 females, is the most prevalent genetic cause of heritable intellectual disability and the most common monogenic cause of autism spectrum disorder. The full mutation of the Fragile X Messenger Ribonucleoprotein-1 gene, characterized by an expansion of CGG trinucleotide repeats (>200 CGG repeats), leads to fragile X syndrome. Currently, there are no targeted treatments available for fragile X syndrome. In a recent large multi-site trial, FXLEARN, the effects of the mGluR5 negative allosteric modulator, AFQ056 (mavoglurant), were investigated, but did not show …

Interview: Kimi Eisele, Steven M. Schnell

The Geographical Bulletin

Kimi Eisele1 is a writer, dancer/choreographer, performer, director, visual artist, and educator based in Tucson, Arizona. Drawing on her MA in geography and a long-standing interest in place and space, she creates works that engage local landscapes, including ecosystems, political systems, and human communities. In 1997, while a graduate student in geography at the University of Arizona, she founded you are here: the journal of creative geography, an interdisciplinary outlet for place-based writing and art, a publication that is still going strong.

Immunomodulation Of Macrophages In Diabetic Wound Individuals By Structurally Diverse Bioactive Phytochemicals, Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ishani Sadhukhan, Riya Sarkar, Krishnendu Ganguly, Saurav Barman, Rajkumar Maiti, Sanjoy Chakraborty, Tandra R. Chakraborty, Debasis Bagchi, Pradipta Banerjee

Publications and Research

Diabetes-related ulcers and slow-healing wounds pose a significant health risk to individuals due to their uncertain causes. Mortality rates for diabetes foot ulcers (DFUs) range from 10% after 16 months to 24% after five years. The use of bioactive phytochemicals can play a key role in healing wounds in a predictable time. Recent literature has demonstrated that various natural substances, including flavonoids, saponins, phenolic compounds, and polysaccharides, play key roles at different stages of the wound-healing process through diverse mechanisms. These studies have categorized the compounds according to their characteristics, bioactivities, and modes of action. In this study, we evaluated …

Trophic Niche Of A Nonnative Invader And Environmental Drivers Of Its Increasing Populations In The Coastal Everglades, Grace Kahmann, Jennifer S. Rehage, Jordan A. Massie, James A. Nelson, Rolando O. Santos, Natasha M. Viadero, W. Ryan James, Ross E. Boucek, Derek P. Crane, Ryan J. Rezek

Marine Science

The Florida Everglades is a critically important, but highly threatened ecosystem that is becoming increasingly susceptible to the invasion of non-native species. This study investigated the ecological role of the invasive peacock eel (Macrognathus siamensis) within this ecosystem using 15 years of electrofishing data and stable isotope analysis. We investigated the population trends of peacock eels at the marsh-mangrove ecotone of the Shark River Estuary, the environmental factors contributing to their abundance, and the potential interactions they may have with native fish assemblages and coastal food webs. We used stable isotope analysis to provide insights into the basal resource contribution …

S6k1 Controls Dna Damage Signaling Modulated By The Mrn Complex To Induce Radioresistance In Lung Cancer, Ali Calderon-Aparicio, Jun He, Nicole L. Simone

Department of Radiation Oncology Faculty Papers

Radiation is a mainstay of lung cancer treatment; however, resistance frequently develops. Identifying novel therapeutic targets to increase radiation sensitivity is crucial. S6K1 is a serine/threonine kinase known to regulate protein translation which is associated with radioresistance, but the mechanisms involved are unknown. We proposed to determine whether S6K1 promotes radioresistance by regulating DNA repair in lung cancer. Colony formation, protein expression and proliferation were assessed. S6K1 was modulated pharmacologically by either PF-4708671 or genetically by Crispr-Cas9. Higher radioresistance levels in lung cancer cells were associated with lower phosphoactivation of MRN complex members, a key activator of radiation-induced DNA repair …

The Importance Of Humanities In A Career-Focused Educational Environment, Geoff Zylstra, Jill Belli, Candido Cabo, Sean Macdonald, Robin Michals, Ann Marie Sowder, Christopher B. Swift

Publications and Research

The humanities have the potential to enhance STEM curriculum in career-oriented professional degree programs. As part of a larger college-wide initiative to develop interdisciplinary curricula, the National Endowment for the Humanities (NEH) awarded a grant to New York City College of Technology to explore the relationship between the humanities and career-focused degree programs in STEM departments. This article describes the design and implementation of coursework that bridges the curricular divides between humanities disciplines and technical or career-focused disciplines by bringing the humanities to bear on science and technology-oriented courses. Specifically, the humanities served to improve technical skills for students in …

Safety Of Dostarlimab In Combination With Chemotherapy In Patients With Primary Advanced Or Recurrent Endometrial Cancer In A Phase Iii, Randomized, Placebo-Controlled Trial (Engot-En6-Nsgo/Gog-3031/Ruby), Annika Auranen, Matthew A Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: In Part 1 of the phase III RUBY trial (NCT03981796) in patients with primary advanced or recurrent endometrial cancer (EC), dostarlimab plus carboplatin-paclitaxel (CP) significantly improved progression-free survival and overall survival compared with CP alone. Limited safety data have been reported for the combination of immunotherapies plus chemotherapy in this setting.

OBJECTIVES: The objective of this analysis was to identify the occurrence of treatment-related adverse events (TRAEs) and immune-related adverse events (irAEs) and to describe irAE management in Part 1 of the RUBY trial.

DESIGN: RUBY is a phase III, randomized, double-blind, multicenter study of dostarlimab plus CP compared …

Broad Applicability Of The Goldspire™ Platform For The Treatment Of Solid Tumors, Jenny Zilberberg, Christopher Uhl, Charles B Scott, David W. Andrews, Mark A Exley

Department of Neurosurgery Faculty Papers

Goldspire™ is a personalized immunotherapy platform that combines whole tumor-derived cells with antisense oligonucleotide (IMV-001) against Insulin-Like Growth Factor-1 Receptor (IGF-1R) in biodiffusion chambers (BDCs; 0.1 μm pore). BDCs are exposed to 5-6 Gy and implanted at abdominal sites for ∼48 h to deliver an antigenic payload and immunostimulatory factors to train the immune system. Lead product IGV-001 was evaluated in newly diagnosed glioblastoma (ndGBM) patients in Phase 1a and 1b trials (NCT02507583). A Phase 2b study (NCT04485949) recently completed enrollment. Preventative treatment with tumor-specific products manufactured with Goldspire limited tumor progression and extended overall survival in mice challenged with …

Inorganic Polyphosphate Promotes Colorectal Cancer Growth Via Trpm8 Receptor Signaling Pathway, Valentina Arrè, Chen Shen, Et Al.

2020-Current year OA Pubs

BACKGROUND: Colorectal cancer (CRC) is characterized by a pro-inflammatory microenvironment and features high-energy-supply molecules that assure tumor growth. A still less studied macromolecule is inorganic polyphosphate (iPolyP), a high-energy linear polymer that is ubiquitous in all forms of life. Made up of hundreds of repeated orthophosphate units, iPolyP is essential for a wide variety of functions in mammalian cells, including the regulation of proliferative signaling pathways. Some evidence has suggested its involvement in carcinogenesis, although more studies need to be pursued. Moreover, iPolyP regulates several homeostatic processes in animals, spanning from energy metabolism to blood coagulation and tissue regeneration.

RESULTS: …