Digital Commons Network^™

The Ccu Disease Hunters: Putting Undergraduate Research To Work To Improve Community Health And Training The Next Generation Of Doctors, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.

Restoration Of Neural-Based Function: Collaborative, Multidisciplinary Research To Develop Neurorehabilitation Knowledge, Measures, And Tools To Improve Function In The Real World, Steven A. Kautz

Journal of the South Carolina Academy of Science

No abstract provided.

Brachial Macroparasite Loads In Estuarine Young-Of-Year Striped Mullet (Mugil Cephalus), Triston Rice

Honors Theses

Climate change is a growing threat to marine habitats globally. One ecological impact that warming water temperatures poses is the increased metabolic rate of many parasite species. Their promoted reproductive and feeding rates could pose a threat to the stability of many host populations. Parasites of the gills, or brachial parasites, are especially concerning to fish populations globally. As parasitism is not limited to a specific taxon and comprises a large diversity of ecomorphs and behaviors, geographically distinct areas may be differentially affected by the changing prevalence of parasites. This study aimed to survey current brachial parasite abundance and prevalence …

Danger! Ai Art Directors Ahead: An Analysis Of Text-To-Image And Text-To-Video Ai Integrations In Production Design For Film And Television, Katherine Gaylord, Charles Howard, Richard Rohrer

Honors Thesis

The Artificial Intelligence (AI) boom in the last decade has sparked exponential excitement, especially in white collar industries, for the possibilities of cost-cutting and streamlining tasks across industries. However, creative industries which were historically driven by human artistry report majority fear regarding copyright/fair-use, legal protections, and job security.

Production Designs and Art Departments in particular question how, or even if, their talent and creativity will fit into an AI powered entertainment industry. Since the inception of filmmaking, Art Departments have brought fantastical visions to life through set design, props, art, costumes, and beyond. Yet, in the age of AI, Text-to-Image …

Online Voting: Should Ohio Adopt Online Voting For Voters With Disabilities?, Audrey Mcconihe

Journal of Law and Health

This Note argues that Ohio should implement a limited online voting system for voters with disabilities in order to expand meaningful access to the voting while preserving election integrity. Drawing on the Americans with Disabilities Act, the Rehabilitation Act of 1973, the Voting Rights Act of 1965, and the Help America Vote Act, this Note contends that Ohio’s current absentee voting framework continues to impose substantial barriers on disabled voters by denying many individuals the ability to cast ballots privately, independently, and safely.

The Note examines how the COVID-19 pandemic exposed longstanding deficiencies in American voting infrastructure, particularly for disabled …

Hotspot Analysis Of Nitrate And Arsenic Concentrations In Minnesota Well Water, Jadyn Keeler

Arts & Sciences Undergraduate Showcase

Water contamination is one of the biggest threats to water supply and can have long term human health consequences. It is key to identify vulnerable regions to develop better management strategies. This project utilizes hotspot and outlier geospatial analysis to locate areas across Minnesota with elevated levels of nitrate and arsenic in well water and better understand potential factors that might be influencing this. Statistically significant hotspots and cold spots were identified with up to 99% confidence. Hotspots of nitrate were located mainly in the south-central region while hotspots of arsenic were located primarily in the western and south-central portions …

Neuroprotective Effects Of Estradiol And Genistein And Interactions With Aromatase Inhibitions Post Cerebellar Lesion In Male Zebra Finches, Grace E. Thompson, Anthony P. Irovic

Honors Theses

Across vertebrates, peripheral and brain-derived estradiol (E₂) promotes neuroplasticity. After injury, E₂ can be derived locally from testosterone via aromatase (AROM), an enzyme that is upregulated in glia at the site of neural injury. E₂disrupts testicular function and elevates cancer and stroke risk, primarily via binding to estrogen receptor alpha (ER α). Genistein (GEN), a phytoestrogen, is similar to E₂ but binds preferentially to estrogen receptor beta (ER β). It may offer neuroprotection without adverse effects of E₂. We used adult male zebra finches (ZF) to model neuroprotective effects of E_{2 …}

Rational Design And Efficacy Evaluation Of A Novel Solid Dispersion-Based Bempedoic Acid–Ezetimibe Fixed-Dose Combination Tablet Versus Nexlizet®, Mohamed A. Heikal, Wael Ali, Mahmoud A. Mahdy, Eman Gomaa

Nanotechnology Research Centre

Background/Objectives: For hyperlipidemic patients with statin resistance, a fixed-dose combination of a non-statin drug such as ezetimibe (EZT) and bempedoic acid (BA) provides a significant benefit. Although both drugs exhibit poor aqueous solubility, the oral bioavailability of EZT is more critically limited by dissolution, whereas BA maintains adequate absorption due to its high intestinal permeability. With regard to the reference product, Nexlizet® (180/10 mg), our study focused on developing a novel tablet with superior in vitro performance without incorporating sodium lauryl sulfate (SLS), as it may potentially alter BA absorption. Methods: The solid dispersion technique (co-precipitation) was applied using the …

Clemson Commencement Program, May 2026, Clemson University

Clemson Commencement Programs

No abstract provided.

Systemic Α₂-Agonist Use And Lower Hazard Of Glaucoma Compared With Β-Blockers: A Cohort Study, Ibrahim Abboud, Amin Z. Khudari, Abdelaziz Abdelaal, Amr Almobayed, Subhi J. Al'aref, Jonathan S. Myers, Richard K. Lee, Abdelrahman M. Elhusseiny

Wills Eye Hospital Papers

OBJECTIVE: Systemic antihypertensive medications may influence glaucoma-related outcomes through intraocular pressure-dependent and vascular mechanisms. While topical α₂-agonists are established glaucoma therapies, the association between systemic α₂-agonists and glaucoma hazard remains unexamined; we compared their hazard with systemic β-blockers in adults with hypertension.

METHODS AND ANALYSIS: We conducted a multicentre retrospective cohort study using deidentified electronic health records. Adults aged ≥40 years with hypertension and chronic exposure to systemic α₂-agonists or β-blockers were included. Patients with pre-existing ocular hypertension (OHT), primary open-angle glaucoma (POAG), concomitant comparator use, or inadequate ophthalmic follow-up were excluded. We balanced cohorts using propensity score matching (PSM) …

Exploring The Impact Of Ungrading On Student Engagement And Motivation In A First-Year Composition Class, Mary B. Gruis

Dissertations, Theses, and Projects

This study investigated the association between student engagement, motivation, and self-efficacy in college-level writing-intensive courses using an ungraded approach. Motivated by disillusionment with traditional grading methods and inspired by texts on equitable grading and culturally responsive teaching, the researcher explored how ungrading could foster deeper learning and equitable educational practices. Grounded in Bandura’s (1997) self-efficacy framework, this qualitative case study examined the lived experiences of first-year composition students at a two-year institution. Data collection included student interviews, student reflections, and an instructor interview. The analysis revealed themes aligned with self-efficacy, engagement, and motivation, suggesting that ungrading positively impacted students' perceptions …

Comparative Behavioral Impacts Of Neuroactive Pharmaceuticals On Crayfish Locomotion, Grace Elizabeth Smith

Masters Theses

Pharmaceuticals are increasingly recognized as contaminants of concern in aquatic ecosystems, often entering waterways due to incomplete removal by wastewater treatment plants. Despite frequent detection, the effects of these compounds on non-target, neurochemically sensitive organisms such as crayfish remains underexplored. Gabapentin, an anticonvulsant that binds to presynaptic voltage-gated calcium channels and reduces excitatory neurotransmitter release, is one such emerging contaminant. Given crayfish’s ecological importance and sensitivity to neuroactive substances, exposure to gabapentin may disrupt key behaviors such as locomotion. To place gabapentin’s effects in context, we also examined escitalopram (Lexapro), a selective serotonin reuptake inhibitor that elevates synaptic 5-HT, and …

Dissecting The Connection Between Technological Advancement And Environmental Justice Through An International Perspective, Benson H. Le

Honors Theses

This thesis dissects the connection between technological advancement and environmental justice through an international perspective. With modern-day technologies advancing by the day, the implications of these technologies on our environment have been rising as well. This thesis looks to dissect the connection between these two entities, as well as view this connection through an international lens. Countries around the world view this connection very differently, and the way these technologies are implemented within the environment is drastically different based on different international views. This thesis aims to answer the questions about this phenomenon. How do countries around the world view …

Beyond The Bug: How The Covid-19 Pandemic Exposed Longstanding Systemic Failures In The United States Workforce And Economy, Abbey M. Markley

Honors Theses

The purpose of this thesis is to investigate and discuss how longstanding systemic failures in the United States exacerbated the effects the COVID-19 pandemic had on the American economy, essential healthcare workers, and overall public trust in institutions. A review of the existing literature surrounding this topic and the subsequent results of various studies were used to compose this thesis. The United States has a painful lack of worker protections and tends to view members of its workforce as expendable, even in times such as pandemic when they are deemed essential. Healthcare workers in particular faced increasing threats to their …

Determining The Relatedness Of Simian Varicella Virus Strains Using Polymerase Chain Reactions And Delta Herpesvirus-Dervied Primers, Ellyn M. Waits

Honors Theses

This study examines genetic variation among strains of Simian Varicella Virus (SVV) using genomic analysis. The primary goal of this experiment was to observe potential genomic differences among the Liverpool vervet virus (LVV), the Tsukuba herpesvirus, and the Delta herpesvirus (DHV) strains using primer sets developed from the fully sequenced DHV strain. SVV strains were initially cultivated in Vero cell cultures to begin viral propagation. Viral proliferation in these cell cultures enables DNA isolation via standard purification methods. The extracted viral DNA is subjected to polymerase chain reaction (PCR) amplification targeting specific regions of open reading frames (ORFs) in the …

Antibiotic Resistance Patterns In Bacterial Isolates From Mississippi Gulf Coastal Environments, Lawler F. Horn

Honors Theses

Coastal environments host diverse microbial communities that play essential ecological roles but may also serve as reservoirs for antibiotic-resistant bacteria. This study investigated patterns of antibiotic resistance in microbial isolates collected from public beaches along the Mississippi Gulf Coast. A total of 143 bacterial isolates exhibited growth and were included in antibiotic susceptibility screening. High levels of antibiotic resistance were observed, with 137 of 143 isolates showing growth on vancomycin, 124 on amoxicillin, and 102 on erythromycin. Resistance to kanamycin (19/143 isolates) and tetracycline (33/143) was less common. Multidrug resistance was widespread, with 101 isolates (70.6%) resistant to three or …

Lifestyle And Activity Patterns Of The Classic Period Maya From Chac Balam And San Juan, Ambergris Caye, Belize, Abigail L. Hornbeck

Honors Theses

Bioarchaeological research often uses skeletal remains to reconstruct patterns of activity and labor in past populations. This study examines potential sex-based differences in long bone morphology among individuals from the Classic Maya sites of Chac Balam and San Juan on Ambergris Caye, Belize. These coastal communities participated in maritime trade networks, and daily activities such as cargo transport, canoe travel, and fishing may have placed distinctive mechanical stresses on the skeleton. The goal of this study was to evaluate whether measurable differences in bone structure between males and females reflect differences in habitual activity patterns.

Two complementary methods were used …

Esports Cosmopolitan Canopy, Reice Hicks

Honors Theses

This thesis concerns the area of sociology. Specifically, it is a sociological study of a community on Ole Miss’s campus and how they form what is known within the sociology field as a “cosmopolitan canopy,” a term coined by Elijah Anderson. Using this term, I proceed to prove not only how the Ole Miss Esports club falls under this jurisdiction, but the effects of esports on the youth as a whole, both positive and negative. All of my data was extracted via literature review, online research, note-taking, visual observation, and one-on-one interviews with people involved with the club. The entire …

Spartan Daily, May 7, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 43

Cloud-Deployed Rna-Seq Analytics For Identifying Imaging And Therapeutic Targets In Chemotherapy-Induced Toxicities, Zhimu Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Chemotherapy has significantly improved cancer survival rates; however, many anticancer agents induce severe acute and chronic side effects that substantially reduce patient quality of life and limit therapeutic efficacy. Despite their clinical importance, the molecular mechanisms underlying chemotherapy-induced toxicities across different organs remain incompletely understood, in part due to the lack of integrated, scalable, and accessible analytical platforms capable of synthesizing large transcriptomic datasets across tissues and experimental models.

This thesis describes the development of a cloud-deployed RNA-seq analytics platform designed to identify candidate imaging biomarkers and therapeutic targets associated with chemotherapy induced toxicities. The platform integrates large-scale transcriptomic datasets …

Genetic Analysis Of The X-Linked Adrenoleukodystrophy Gene Abcd1 In Drosophila Uncovers A Conserved Phenotype, Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan C Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser, Suzette M Huguenin, Michael F Wangler

Duncan NRI Faculty and Staff Publications

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients, including adult males and most affected female carriers, experience a chronic progressive myelopathy. Adrenocortical failure is observed in almost all male patients, with the age of onset varying, sometimes being the first diagnostic finding. The gene underlying this spectrum of disease encodes an ATP-binding cassette (ABC) transporter that …

Gut Microbiota Modulation Of Regulatory Dna Elements Revealed By Massively Parallel Functional Characterization, Chadmirah Zaratiana, Adheet Ganesh, Yang E Li, Et Al.

2020-Current year OA Pubs

Cis-regulatory elements (CREs) are central to dynamic gene regulation in hepatocytes, yet most functional annotations derive from in vitro models that poorly capture physiological regulation. We systematically profiled 109,386 human liver-derived CREs using massively parallel reporter assays in hepatocytes under matched in vitro and in vivo conditions. In vivo-active functional CREs (fCREs) were enriched for H3K27ac and chromatin accessibility and were regulated by diverse transcription factors in the human liver. We further demonstrate that gut microbiota-derived signals modulate fCRE activity and target gene expression in vivo, in part via the KEAP1/NFE2L2 antioxidant pathway. Specific microbial metabolites directly altered the activity …

Establishing Sustainable Vegetation On A Challenging Legacy Ccr Site, Derek Oosterhouse, Blake Arthur

World of Coal Ash Proceedings

American Electric Power (AEP) is closing and restoring a legacy Coal Combustion Residuals (CCR) site in Ohio that once held a power plant that pioneered innovative steam generation technology. The plant was closed in 1975. Today, the legacy CCR site is being transformed back to natural, sustainable vegetation. To comply with and close the Stormwater Pollution Prevention Plan (SWPPP) permit, permanent stabilization is required on the site. AEP, one of the largest electric companies in the country, holds a core principle to respect the environment through creative sustainable solutions. AEP connected with Profile Products, the world’s largest manufacturer and supplier …

Improving Economic And Environmental Outcomes Of Legacy Coal Ash Ponds, Grace Wilken

World of Coal Ash Proceedings

This project demonstrates a novel approach to utilize legacy coal ash waste ponds by processing the solids for use in cement/concrete and bioremediating the water fraction through algae cultivation. The algal biomass can then be used for animal feed, biofuels, or other valuable bio-products. There is an increasing demand for more environmentally friendly and cost-effective materials for concrete production, such as coal fly ash, yet a decreasing supply of ash as coal power plants are decommissioned in the transition to other energy sources. However, there are billions of tons of coal ash accumulated in legacy ash ponds across the US. …

Ensuring Quality Geosynthetics Installations Throughout The Project Lifecycle, Glen Toepfer

World of Coal Ash Proceedings

Geosynthetics serve numerous functions in containment systems used within the Coal Ash Industry and ultimately protect the site owner from liability. A failure in the geosynthetics containment system exposes the owner to liability; therefore, it is imperative that these geosynthetic containment systems be installed correctly to mitigate the risk of failure. Avoiding failure is not just the responsibility of the geosynthetics installer – it is the responsibility of every party involved in the project lifecycle from conception through post-closure. In fact, the success of the field installation is largely determined before the first panel of geomembrane is ever installed. The …

Riki&Dolphin: Real Time Data Transmission From The Bottom Of A Cave To A Website, Luca Tringali, Giacomo Canciani Dr., Tecla Tripari, Alexander Debenjak, Caterina Bearzotti

International Journal of Speleology

Coming from over 10 years of experience in cave monitoring in northeast Italy, Gruppo Speleologico Talpe del Carso, has designed Riki and Dolphin: customizable, low cost, and easy to assemble tools for getting real time data transmission from the bottom of a cave, even underwater, to a webserver. Their use has been tested to monitor air temperature inside the Abisso Bonetti Cave (Classical Karst, Italy), proving for the first time that a cave in Gorizian Karst can systematically be colder than the outdoor temperature even in winter, recording an internal temperature even lower than 0°C. The Dolphin device can be …

Gun Rights And Public Safety: A Constitutional Tension, Kirsten Zonkowski

NSU Undergraduate Law Journal

This paper examines the constitutional tension between gun regulation and the right to bear arms in the United States. By analyzing landmark Supreme Court cases and major legislative developments, tracing the historical foundations of the Second Amendment, exploring judicial interpretations, and identifying ongoing doctrinal challenges, it highlights  the central constitutional conflict: the Second Amendment guarantees an individual right to keep and bear arms, yet that right often clashes with the government’s responsibility to protect citizens and maintain public safety. Courts and legislatures continue to struggle to define the limits of governmental authority without infringing upon fundamental constitutional rights, revealing an …

Age And Genotype-Dependent Baseline Characterization Of Spatial Learning And Memory In App/Ps1 Rats Using The Morris Water Maze, Thomas George, Mohammadreza Arbab, Nathanael Ricardo Alicea, Mahdie Kerdari, Christopher Janson

Rowan-Virtua Research Day

Background: Alzheimer’s disease (AD) is characterized by progressive cognitive decline. Transgenic APP/PS1 rat models offer improved translational relevance compared to mouse models due to closer similarity to human neurobiology.

Objective: To establish a baseline profile of spatial learning and memory across age and genotype in rate model.

Methods: The Morris Water Maze (MWM) was used to assess four groups of rats: young Wild Type (WT), young APP/PS1 (AD), middle-aged WT, and middle-aged AD. Spatial learning was evaluated during acquisition (Day 1–4) using cumulative proximity and escape latency. Memory was assessed using probe trials (Day 2–4). Swim velocity …

In Patients With Acne Vulgaris, How Do Standard Acne Treatments Combined With Adjunct Microbiome-Targeted Therapies Compare To Standard Acne Treatments Alone In Affecting Clinical Outcomes?, Sree Gowri Sudharshan

Rowan-Virtua Research Day

Background: Acne vulgaris is a very common chronic skin condition that occurs when hair follicles become clogged with oil, dead skin cells, and bacteria. Nearly 50 million Americans are affected annually, and it usually occurs around puberty. Due to rising antibiotic resistance and unwanted side effects to current mediations, emerging research on the role of skin and gut microbiome in acne development is of interest.

Hypothesis: Adjuvant microbiome-targeted therapies may offer better clinical outcomes than standard acne treatments alone.

Methods: Literature search performed in PubMed and Embase using keywords related to acne vulgaris, microbiome-targeted therapies, and targeted acne treatments. Of …

Effect Of Parkinson’S Disease On The Lateralization Of The Digastric Muscle In A Rodent Model, Estelle Richardson, Francois Gould

Rowan-Virtua Research Day

In Parkinson’s disease, the loss of dopaminergic neurons in the substantia nigra can cause dysphagia, which affects all phases of swallowing. In swallowing, bilateral pairs of muscles under the control of independent unilateral neural mechanisms must simultaneously activate to coordinate their movements and produce a swallow. However it is unknown how Parkinson’s disease impairs the activation of the right and left sides of those muscles. In this study we tested how Parkinson’s disease impacts the lateralization of the digastric muscle in rats. We hypothesized that Parkinson’s disease will cause a difference in activation of the right and left digastric muscles …