Digital Commons Network^™

Medical Students’ Self-Perceived Knowledge And Clinical Comfort With Genetics In Pakistan, Maheen Arshad, Angela Trepanier, S Shahrukh Hashmi, Rizwan Naeem, Saqib Mehmood, Myla Ashfaq

Faculty, Staff and Student Publications

Pakistan has a high rate of genetic disorders and neonatal mortality concurrent with noted lack of genetic counselors and geneticists. To meet the needs of the patient population, the responsibility of providing clinical genetic services falls on general and specialty physicians. However, their education regarding these essential services is not standardized in medical school curricula nor has it ever been evaluated. The purpose of this work is to describe the self-perceived knowledge, clinical comfort, and perspectives of Pakistani medical students toward their medical genetics' education. A web-based survey was distributed electronically to medical schools around the country. The survey comprised …

Physical Exercise-Related Manifestations Of Long Covid: A Systematic Review And Meta-Analysis, Chen Zheng, Jun-Jie Chen, Zi-Han Dai, Ke-Wen Wan, Feng-Hua Sun, Jun-Hao Huang, Xiang-Ke Chen

Faculty, Staff and Student Publications

OBJECTIVE: This study aims to systematically assess physical exercise-related symptoms of post-acute sequelae of SARS-CoV-2 infection (PASC or long COVID) in coronavirus disease 2019 (COVID-19) survivors.

METHODS: Eight databases were systematically searched on March 03, 2024. Original studies that compared physical exercise-related parameters measured by exercise testing between COVID-19 survivors who recovered from SARS-CoV-2 infection over 3 months and non-COVID-19 controls were included. A random-effects model was utilized to determine the mean differences (MDs) or standardized MDs in the meta-analysis.

RESULTS: A total of 40 studies with 6241 COVID-19 survivors were included. The 6-min walk test, maximal oxygen consumption (VO …

Dominantly Inherited Muscle Disorders: Understanding Their Complexity And Exploring Therapeutic Approaches, Andrew R Findlay

2020-Current year OA Pubs

Treatments for disabling and life-threatening hereditary muscle disorders are finally close to becoming a reality. Research has thus far focused primarily on recessive forms of muscle disease. The gene replacement strategies that are commonly employed for recessive, loss-of-function disorders are not readily translatable to most dominant myopathies owing to the presence of a normal chromosome in each nucleus, hindering the development of novel treatments for these dominant disorders. This is largely due to their complex, heterogeneous disease mechanisms that require unique therapeutic approaches. However, as viral and RNA interference-based therapies enter clinical use, key tools are now in place to …

Pkmyt1 Is A Marker Of Treatment Response And A Therapeutic Target For Cdk4/6 Inhibitor-Resistance In Er+ Breast Cancer, Anran Chen, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER+) breast cancer, however drug resistance is common. In this study, proteogenomic analyses of patient-derived xenografts (PDXs) from patients with 22 ER+ breast cancer demonstrated that protein kinase, membrane-associated tyrosine/threonine one (PKMYT1), a WEE1 homolog, is estradiol (E2) regulated in E2-dependent PDXs and constitutively expressed when growth is E2-independent. In clinical samples, high PKMYT1 mRNA levels associated with resistance to both ET and CDK4/6 inhibition. The PKMYT1 inhibitor lunresertib (RP-6306) with gemcitabine selectively and synergistically reduced the viability of ET and palbociclib-resistant ER+ breast …

Mucosal Adenovirus Vaccine Boosting Elicits Iga And Durably Prevents Xbb.1.16 Infection In Nonhuman Primates, Matthew Gagne, James Brett Case, Igor P Dmitriev, Elena A Kashentseva, Baoling Ying, David T Curiel, Michael S Diamond, Et Al.

2020-Current year OA Pubs

A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1-BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG …

Metabolically Active Neutrophils Represent A Permissive Niche For Mycobacterium Tuberculosis, J Tucker Andrews, G V R Krishna Prasad, Jennifer A Philips, Et Al.

2020-Current year OA Pubs

Mycobacterium tuberculosis (Mtb)-infected neutrophils are often found in the airways of patients with active tuberculosis (TB), and excessive recruitment of neutrophils to the lung is linked to increased bacterial burden and aggravated pathology in TB. The basis for the permissiveness of neutrophils for Mtb and the ability to be pathogenic in TB has been elusive. Here, we identified metabolic and functional features of neutrophils that contribute to their permissiveness in Mtb infection. Using single-cell metabolic and transcriptional analyses, we found that neutrophils in the Mtb-infected lung displayed elevated mitochondrial metabolism, which was largely attributed to the induction of activated neutrophils …

Htlv-1 Infected T Cells Cause Bone Loss Via Small Extracellular Vesicles, Nitin Kumar Pokhrel, Haniya Habib, Shamreethaa Seeniraj, Ancy Joseph, Daniel Rauch, Linda Cox, Robert Sprung, Petra Erdmann Gilmore, Qiang Zhang, Robert Reid Townsend, Lee Ratner, Katherine N Weilbaecher, Deborah J Veis, Et Al.

2020-Current year OA Pubs

Adult T cell leukaemia (ATL), caused by infection with human T- lymphotropic virus type 1 (HTLV-1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we studied the communication between patient-derived ATL cells (ATL-PDX) and HTLV-1 immortalized CD4+ T cell lines (HTLV/T) with osteoclasts and their effects on bone mass in mice. Intratibial inoculation of some HTLV/T leads to a profound local decrease in bone mass similar to marrow-replacing ATL-PDX, despite the fact that few HTLV/T cells persisted in the bone. To study the direct effect of HTLV/T and ATL-PDX on osteoclasts, supernatants were added to murine and human osteoclast …

Deletion Of Tissue Factor Pathway Inhibitor Isoform Beta Or Gamma, But Not Alpha, Improves Clotting In Hemophilic Mice, Irem Eldem, Lilian Antunes-Heck, Renumathi Subramanian, Nina M Lasky, Katrina Ashworth, Jorge Di Paola, Thomas J Girard

2020-Current year OA Pubs

BACKGROUND: Tissue factor pathway inhibitor (TFPI) regulates tissue factor-triggered coagulation. Humans and mice express transcripts encoding for multidistributed (endothelial, platelet, and plasma) 3-Kunitz domain TFPIα and endothelial membrane-anchored 2-Kunitz TFPIβ. Mice express a third transcript, γ, that encodes plasma lipoprotein-associated 2-Kunitz TFPI. In humans, proteolysis of α and/or β produces plasma lipoprotein-associated 2-Kunitz TFPI at lower levels. In clinical trials, monoclonal antibodies that target all TFPI isoforms extend coagulation and correct bleeding in hemophilic patients but with some thrombosis risks.

OBJECTIVES: To determine the impact of TFPI isoform-specific deletions on promoting clotting in hemophilic mice.

METHODS: Engineered TFPI isoform-specific, hemophilic …

Three Classes Of Propofol Binding Sites On Gabaa Receptors, Zi-Wei Chen, Satyanarayana M Chintala, John Bracamontes, Yusuke Sugasawa, Spencer R Pierce, Balazs R Varga, Edward H Smith, Christopher J Edge, Nicholas P Franks, Wayland W L Cheng, Gustav Akk, Alex S Evers

2020-Current year OA Pubs

Propofol is a widely used anesthetic and sedative that acts as a positive allosteric modulator of gamma-aminobutyric acid type A (GABA

Confirmation Of Avian Dispersal Of A Seed Chalcid Wasp In North America And A New Host Record For Megastigmus Aculeatus (Hymenoptera: Megastigmidae), Julie A. Craves

The Great Lakes Entomologist

Dispersal of chalcid wasp larvae inhabiting the seeds of angiosperms by wild birds in North America has never been verified. I describe adult Megastigmus aculeatus Swederus that successfully emerged from seeds extracted from the droppings of six species of native North American non-captive birds. Rosa setigera is also confirmed as a host for this wasp for the first time.

Impact Of Debarking And Bark Grinding On Survival Of Ips Calligraphus (Coleoptera: Curculionidae: Scolytinae), Robert A. Haack, Toby Petrice, John Foltz, Hui Ye

The Great Lakes Entomologist

Chipping and debarking of infested woody material such as branches and logs are common sanitation methods used to kill bark- and wood-infesting insects. The sixspined ips, Ips calligraphus (Germar), is a native North American bark beetle (Coleoptera: Curculionidae: Scolytinae) that infests several pine (Pinus) species. We evaluated I. calligraphus mortality after debarking and grinding, using 12 recently cut longleaf pine (Pinus palustris Mill.) logs that had undergone natural colonization for three weeks in Florida. Initial bark beetle densities were estimated from samples collected the day before debarking. Similar amounts of bark were collected at three steps in …

Phenology And Host Choice Among Common Yet Little Understood Wood Borers (Coleoptera: Bostrichidae) In A Midwestern Savanna, Noah I. Finney, Derek W. Rosenberger

The Great Lakes Entomologist

Horned powder-post beetles (Coleoptera: Bostrichidae) are a geographically widespread family of wood-boring beetles. While members of this family represent important grain pests, are often intercepted in ports, and may play an important role in ecosystem processes, little work has investigated bostrichid life history in their native ranges. This gap limits our ability to assess ecosystem services and invasiveness. Three native species, Amphicerus bicaudatus (Say), Scobicia bidentata (Horn), and Xylobiops basilaris (Say), are commonly found in savannas in Northern Illinois. Although little is currently known about the life history of S. bidentata, A. bicaudatus and X. basilaris can be minor pests …

Changes In Ground Beetle (Coleoptera: Carabidae) Species Assemblages After Removal Of Red Pine (Pinus Resinosa) Overstory On Dry Sand Prairie Sites In Michigan, Robert A. Haack, Toby Petrice, Robert L. Davidson, Robert E. Acciavatti

The Great Lakes Entomologist

Ground beetle (Coleoptera: Carabidae) species assemblages were studied at sites on the Huron-Manistee National Forests in Newaygo County, Michigan. The goal was to monitor changes in carabid diversity on areas where mature red pine (Pinus resinosa Sol. ex Aiton) was removed during the 1996-1997 winter and compare with carabid diversity at nearby natural dry sand prairie sites, natural oak-pine barrens, and uncut red pine stands. The red pine had been planted on dry sand prairie sites during 1940-1950. Sampling with pitfall traps occurred during May-August in both 1996 and 1997, but only July-August in 1999. Overall, 16,259 carabid specimens …

Full Issue, Maryland Birdlife

Maryland Birdlife

No abstract provided.

Blend Feeding Broilers To Daily Nutrient Requirements, J.T. Pope

Proceedings of the Arkansas Nutrition Conference

Broiler producers and nutritionists have used phase feeding as a practical means to define broiler feeding programs. Each feed phase has discreet nutrient definitions intended to be fed for a defined number of days based on a feed mass delivered per broiler. A typical broiler feeding program would consist of three to five feed phases over the production cycle that intend to address the changing nutrient requirements as broilers age. Phase feeding programs are easily defined, practical to manage, and provide a predictable cost structure for broiler producers. Despite the practicality of phase feeding, there are inherent flaws that will …

Current Trends And Experiences From A Contract Research Organization Perspective, Dan Moore

Proceedings of the Arkansas Nutrition Conference

The primary goal of this presentation is to provide an update on the trends of research observed at a contract research organization (CRO) in recent years as it relates to species, study design type and products tested, as well as, challenge models used and products that have shown benefits in various study designs. The information in the presentation is based off of studies conducted from 2014-2024 at one CRO, Colorado Quality Research (CQR), and represents the experiences at CQR. Many of the parameters discussed will be from 2014-2019 and 2020-2024 to observe trends from over 5 years ago and more …

Importance Of A Rooster Feed In Broiler Breeder Production, Alex Corzo, Marcelo Silva

Proceedings of the Arkansas Nutrition Conference

Of all feed phases in poultry production, rooster feeding is arguably the least studied. During the rear phase, there is general agreement that male and female broiler breeders can be provided a common feed program, only differing on feed amounts provided, that results in growth targets reached for each sex. It is during the production phase that there is some disagreement on the best way to support the nutritional needs of the adult rooster. A considerable segment of the world does employ a rooster feed as a way to better support the nutritional needs of working males. Other poultry operations …

Vitamin Update And Sustainability, Edgar Orlando Oviedo-Rondón

Proceedings of the Arkansas Nutrition Conference

This presentation addressed the status of research on vitamin nutrition in poultry species and current recommended levels. The economic, environmental, and socio-political aspects of sustainability are addressed. Most of the information presented is described in detail in the book Optimum Vitamin Nutrition for More Sustainable Poultry Farming (Oviedo-Rondon et al., 2023). However, this presentation also used more recent publications and news of the latest events related to scientific recommendations and the worldwide vitamin market. The objective is to provide a brief overview of scientific findings to aid nutritionists in the decision-making process when selecting optimum levels for poultry nutrition. …

Every Day Feeding Of Broiler Breeder Pullets, David Brandt

Proceedings of the Arkansas Nutrition Conference

Broiler breeders are characterized by their fast growth and sensitivity to light stimuli. Unlike commercial layers, they have a lower egg production rate and are kept on the floor during rearing and laying periods. Fertile eggs are the primary objective, necessitating careful management of their egg-laying properties, while controlling their body weights. Unrestricted feeding leads to early laying with poor peak and persistency in egg production. Therefore, nutrient intake must be restricted to achieve target body weights at light stimulation (22 weeks). This involves both quantitative and qualitative feed restrictions. Quantitative feed restriction can lead to issues such as poor …

Integration Of Commercial Broiler Data Into A Broiler Growth Model, David Brandt

Proceedings of the Arkansas Nutrition Conference

This study explores the alignment of theoretical broiler growth models with practical farm conditions, emphasizing the value of integrating commercial data into simulation models. The EFG Broiler Growth Model, developed by Emmens, Fisher and Gous, is highlighted for its mechanistic approach, predicting growth based on feed intake. While empirical models are useful, they are limited by changes in genetics. Both mechanistic and empirical models struggle to predict how broilers will respond to feed under the challenging conditions typically experienced in commercial operations. The study also discusses the development of empirical models to determine broiler responses to balanced protein and energy, …

Vol. 29, No. 6 - Whole No. 144, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Exploring Depictions Of Mental Health In Popular Hindi-Urdu Cinema, Sara Ahmed

Journal of Critical Global Issues

Hindi-Urdu popular cinema, commonly referred to as Bollywood, largely reflects the evolution of various social attitudes in the Indian subcontinent. In order to better understand these films’ depiction of social attitudes surrounding mental illness and the implications for its treatment, this study creates and analyzes an anthology of Hindi-Urdu movies from the 1940’s to the present that portray some aspect of mental illness. These movies that depict mental illness were grouped into the various aspects of stigma that they portrayed: structural stigma, courtesy stigma, health practitioner stigma, self-stigma, and public stigma. I extracted and analyzed the attitudes towards mental illness, …

Utopian Genderscapes, Michelle C. Smith

Rhetoric

No abstract provided.

Intrinsic And Environmental Drivers Of Pairwise Cohesion In Wild Canis Social Groups, John F. Benson

School of Natural Resources: Faculty Publications

Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission–fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals. We tracked 574 individuals from six species within the genus Canis in 15 countries on four continents with GPS telemetry to estimate the time that pairs of individuals within …

Promoting Pancasila Ideology Through Comic-Based Learning Media, Selly Rahmawati, Nanda Dewi Sundari, Nurul Asyikin Binti Hasan, Septian Aji Permana

Jurnal Civics: Media Kajian Kewarganegaraan

This research’s objectives are to 1) develop a storybook with a picture (comic) as a learning media for Pancasila and Civic Education (PCE) and 2) to evaluate its effectiveness in improving the learning results of grade V elementary school students in learning the values of Pancasila. This is research and development by implementing the ADDIE model, which consists of five stages: analysis, design, development, implementation, and evaluation. The research’s subjects are 27 students of V (A), 28 students of V (B) and eight students of V (C) as experiment, control, and limited test classes, respectively. The result of the development …

"Gregory Berns’ Journey: Uncovering The Emotional Lives Of Cows And Other Animals", Leslie Barcus, Steven Hansch

Tales of WellBeing

Explore Gregory Berns’ heartwarming journey from neuroscientist to farmer, where he uncovers the emotional intelligence of cows, drawing parallels to dogs and advocating for kinder treatment of animals in his new book.

Celebrating The Adventures Of Owney And Boji: How Two Famous Dogs Captured Hearts Across Generations, Kathleen Rowan, Andrew Rowan

Tales of WellBeing

Follow the incredible journeys of Owney, the 19th-century mail train rider, and Boji, Istanbul’s modern-day commuter dog. Learn how these remarkable dogs inspired love, loyalty, and fascination in people across the world, even from a distance.

Does It Stick? A Longitudinal Study Of Introductory Physics For Life Sciences At A Small College, Benjamin D. Geller , '01, Catherine Hirshfeld Crouch

Physics & Astronomy Faculty Works

At Swarthmore College, we began developing an Introductory Physics for Life Sciences (IPLS) course nearly 20 years ago. The electricity, magnetism and optics semester was launched in 2008 and both semesters have been offered regularly since Fall 2015. Two primary goals of this curriculum are (1) to prepare students to effectively use physical models and quantitative reasoning in biological and biomedical contexts, and (2) for students to come to view physics as relevant to the life sciences. To evaluate whether these goals are achieved, we conducted a longitudinal interdisciplinary study assessing students' abilities to use what they learned from IPLS …

Development Of Interactive Manipulative Motion Learning Media Using Adobe Animate For Elementary School Students, Muhsana El Cintami Lanos, Widya Handyani, Jujur Gunawan Manullang, Anes Winartiningsih, Rifqi Festiawan

Jurnal Keolahragaan

Over the past few years, there has been a growing recognition of the importance of integrating technology into educational practices to engage students more effectively. Traditional PE methods and limited resources have hindered effective learning, necessitating new approaches. This research aimed to develop innovative, interactive learning media based on adobe animate to enhance elementary students’ learning outcomes in manipulative movement skills—a crucial component of Physical Education (PE) that fosters physical, social, emotional, and cognitive development. Utilizing the research and development (R&D) method with Borg and Gall's ten-stage model, the study involved experts and participants from five elementary schools in Purwokerto …

Body Weight Training Versus Series 7 Diabetes Dance: Their Influence On Glucose Levels In Patients With Type 2 Diabetes Mellitus, Dikri Muhammad, Sumarjo Sumarjo, Bm Wara Kushartanti, Fatemeh Nourzad

Jurnal Keolahragaan

Managing blood glucose levels is critical for preventing complications associated with type 2 diabetes mellitus (T2DM). Physical activity has been shown to be an effective strategy for glucose control, with various forms of exercise yielding different results. This research aims to explore the effects of body weight training and series 7 diabetes dance on reducing blood glucose levels in patients with T2DM, and to compare the efficacy of these two interventions in achieving glucose control. The type of research was a quasi-experiment with a two groups pre-test post-test design. The series 7 diabetes dance group performed the exercise 4 times …