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Photo Identification On Interactions Between Tursiops Trucatus And Humans To Promote The Importance Of Sustainability, Julia Bronneberg May 2026

Photo Identification On Interactions Between Tursiops Trucatus And Humans To Promote The Importance Of Sustainability, Julia Bronneberg

Undergraduate University Honors Capstones

The Mediterranean Sea is one of the most biodiverse regions, and especially around the Maltese islands, a popular tourist destination where people come to enjoy the beautiful weather and blue waters. Because bottlenose dolphins (Tursiops truncatus) are the most common species people see in coastal areas, they are the primary focus of this research. We care about these bottlenose dolphins because they cannot protect themselves if we are the ones accidentally causing them harm. This study starts from the belief that if we cannot protect the ocean and marine life, then we cannot protect ourselves. We use many resources that …


Waste Wood Biochar As A Potential Agricultural Soil Amendment, Gavin Rahl May 2026

Waste Wood Biochar As A Potential Agricultural Soil Amendment, Gavin Rahl

Honors Theses

Biochar, as a technology, has and continues to be evaluated for a wide variety of purposes including drinking water treatment of heavy metals and air filtration for harmful contaminants. When evaluating the logging industry, a problem has emerged around residual wood waste (slash piles) in the field that biochar production may be able to address. Additionally, agriculture has begun to look for alternatives to nitrate heavy fertilizers that can cause eutrophication in waterways that biochar has the potential to address. In this study, the effect of biochar addition was assessed in agricultural fields with tight margin alfalfa/grass hay crops to …


Taxidermy And Technology: A History Of Climate Change Exhibitions At American Museums Of Natural History, Laura Haushalter, Amy Woodson-Boulton May 2026

Taxidermy And Technology: A History Of Climate Change Exhibitions At American Museums Of Natural History, Laura Haushalter, Amy Woodson-Boulton

Honors Thesis

My research is on the history of temporary and permanent climate change exhibitions at natural history museums in the United States. My primary research question is: How have natural history museums responded to human-caused environmental destruction through their exhibitions, and what, if anything, are natural history museums doing now to address our current environmental crisis? My research begins with a historiography of natural museums and examines how early 20th-century museums responded to a sense of environmental crisis and widespread threats of species extinction. In the early 20th century, museums shifted from Victorian-era glass cases to modern and artistic dioramas that …


The Illocutionary Constitution Of Second Nature: An Interpretive Reconstruction Of Hegel’S Philosophy Of Language, Roland William Carspecken May 2026

The Illocutionary Constitution Of Second Nature: An Interpretive Reconstruction Of Hegel’S Philosophy Of Language, Roland William Carspecken

Electronic Theses and Dissertations

This dissertation offers an interpretive reconstruction of Hegel’s philosophy of language. Rich reflections on the nature of language and its significance to human life can be found across Hegel’s works. Many of these reflections strongly suggest that language plays a vital role in Hegel’s philosophical project. Yet surprisingly, Hegel never set down a comprehensive account of his view of language. To this day, it remains a matter of dispute whether Hegel’s writings on language are consistent enough to amount to a single ‘philosophy of language’ and, if they are, what sort of philosophy of language they might offer. In the …


“The Right Of Black Folk To Love And Enjoy”: Black Romanticism, Pleasure, And Poetics, 1900-1920, John D. Hadlock May 2026

“The Right Of Black Folk To Love And Enjoy”: Black Romanticism, Pleasure, And Poetics, 1900-1920, John D. Hadlock

Electronic Theses and Dissertations

This dissertation explores poetry written at the turn of the twentieth century in order to closely examine what I call the “Black Romantic” impulse of the Harlem and New Negro Renaissances. I argue that Black American poets turned to a Romantic notion of the poet as cultural representative and of poetry as a radical celebration of beauty that disavowed and disputed social ills, namely racist ideologies in America, while simultaneously demanding the right of Black pleasure-taking. However, I also contend that Black American poets of various backgrounds and identities used different poetic, rhetorical, and artistic strategies to elevate the status …


Through The Lens Of “Kigo”: Understanding Japanese American Wwii Poetry, Grace C. Shields May 2026

Through The Lens Of “Kigo”: Understanding Japanese American Wwii Poetry, Grace C. Shields

Honors College Theses

In 1957, nearly ten years after the closing of Tule Lake Segregation Center in Newell, California, the last of the ten War Relocation Authority (WRA) concentration camps to close, author Keiho Soga writes on a piece of paper:

“Untitled”

By: Keiho Soga

Beyond the forbidding fence 

Of doubled barbed wire 

The mountain, 

Aglow with purple,

Sends us its greetings.

In this brief moment of reflection, Soga recounts his time in Sand Island Internment Camp, another of the Japanese American internment camps established during World War II by the United States government after the attack on Pearl Harbor in December 1941. …


Life Histories Of Two Sgcn Procambarus Species In East Texas, Mckenzie A. Adkins May 2026

Life Histories Of Two Sgcn Procambarus Species In East Texas, Mckenzie A. Adkins

Biology Theses

Within freshwater systems, crayfish play notable roles by shaping habitats and linking food web levels. Yet even with such influence, knowledge about numerous species is incomplete, which hinders protection strategies. Found only in the Neches River basin in eastern Texas, Procambarus nechesae and Procambarus nigrocinctus have different conservation statuses, mainly because data on their life history remains sparse. These two species are not closely related and are analyzed independently in this study. Research into traits tied to survival and environmental preferences was carried out so that informed decisions on conservation efforts can be made for these species. The goal of …


From Farewell To Fáilte: The Voices Of Iowa’S Irish Daughters, Katie Hermanson May 2026

From Farewell To Fáilte: The Voices Of Iowa’S Irish Daughters, Katie Hermanson

History Theses, Dissertations, and Student Creative Activity

Irish women’s immigration to Iowa brought rich culture and lasting impacts, despite their contributions being silenced by history. Women left Ireland for economic opportunity and education abroad to support their impoverished families. Millions emigrated between 1830 and 1915, spreading across the world. The Irish women who came to the United States encountered discrimination and cultural stereotyping as they worked in domestic service, developed religious orders, taught school, owned businesses and raised families. Women bore the burden of supporting their families in Ireland by sending remittances home and communicating between countries. Their cultural identity as exiles dwelled in guilt for leaving …


Homelessness In The Caribbean: From Colonial Roots To Rights-Based Responses, Wilmy Dessalines, Tamar Ezer, Gabriela Valentín Diaz May 2026

Homelessness In The Caribbean: From Colonial Roots To Rights-Based Responses, Wilmy Dessalines, Tamar Ezer, Gabriela Valentín Diaz

University of Miami International and Comparative Law Review

This Article provides an analysis of homelessness across four Caribbean localities—the Dominican Republic, Haiti, Jamaica, and Puerto Rico. Each locality brings a diverse history connected to colonial legacies and realities from Spain, France, the United Kingdom, and the United States. They capture a cross-section of the Caribbean and reveal that homelessness is shaped by legal and governance systems rooted in colonial inheritance that promote exclusion over social protection: from vagrancy laws that regulate presence in public space to land systems that legalize dispossession and facilitate displacement. Laws punishing vagrancy and life-sustaining activities serve as instruments of social control that systematically …


The Machinery Of Division, Ethan D. Ernst May 2026

The Machinery Of Division, Ethan D. Ernst

Honors Capstones

This single chapter of a future fictional work follows the protagonist, Grace Scott, as her twenty-first birthday approaches, yet things are not as they seem. In this world, alien creatures known as the Marauders have forced humanity to hide within fortified cities, while all children are at risk of mutating into these monsters and eventually losing their minds. This risk is guaranteed to disappear after reaching the age of twenty-one, making it the most celebrated birthday for every society on Earth. As this grand day arrives for Grace, however, strange events occur that indicate that the world may be about …


Tunable Tripcides Suppress Virulence Factor Secretion During Staphylococcus Aureus Infection And Kill Dormant Cells, Hasan Tükenmez, Taylor M Nye, Suzanne Hickerson, Chloe L P Obernuefemann, Jerome S Pinkner, Karen W Dodson, Michael G Caparon, Scott J Hultgren, Et Al. May 2026

Tunable Tripcides Suppress Virulence Factor Secretion During Staphylococcus Aureus Infection And Kill Dormant Cells, Hasan Tükenmez, Taylor M Nye, Suzanne Hickerson, Chloe L P Obernuefemann, Jerome S Pinkner, Karen W Dodson, Michael G Caparon, Scott J Hultgren, Et Al.

2020-Current year OA Pubs

Antimicrobial resistance (AMR) in common bacterial pathogens, including methicillin-resistant


Inflammatory Markers In The Emergency Department And Ptsd Symptoms In The Aurora Study: A Longitudinal Cohort Study, Kristen Nishimi, Stacey L House, Et Al. May 2026

Inflammatory Markers In The Emergency Department And Ptsd Symptoms In The Aurora Study: A Longitudinal Cohort Study, Kristen Nishimi, Stacey L House, Et Al.

2020-Current year OA Pubs

BACKGROUND: Systemic inflammation is hypothesized to contribute to post-traumatic stress disorder (PTSD) vulnerability. Few studies have examined inflammation shortly after trauma as a predictor of later PTSD symptoms. We examined whether inflammation from the emergency department (ED) post-trauma is associated with PTSD symptom severity over the following 6 months.

METHODS: Our sample included 742 AURORA participants, a longitudinal cohort of patients in 29 EDs across the United States after a traumatic stressor, followed up to 6 months. Plasma cytokines were assessed from a study blood draw in the ED: an inflammatory index (standardized sum of generally pro-inflammatory markers interleukin [IL]-6, …


Oxytocin And Vasopressin Receptors Mediate Dopamine Release In The Nucleus Accumbens, Rebecca Chari Crenshaw May 2026

Oxytocin And Vasopressin Receptors Mediate Dopamine Release In The Nucleus Accumbens, Rebecca Chari Crenshaw

Electronic Theses and Dissertations Archive

Oxytocin (OXT) is a potential therapeutic target for substance use disorders due to its modulatory effects on mesolimbic dopamine function. While OXT activity in the nucleus accumbens (NAc) influences dopamine release, the receptor mechanisms underlying these effects remain unclear. Oxytocin receptors (OXTRs) and vasopressin 1A receptors (V1aRs) are both expressed in the NAc and may differentially regulate dopamine function. This study examined how selective activation and blockade of OXTRs and V1aRs within the NAc modulate phasic and tonic dopamine release using in vivo amperometry in male and female mice. Intra-NAc OXT decreased phasic, but not tonic, dopamine release. Similarly, activation …


Inflammatory Markers In The Emergency Department And Ptsd Symptoms In The Aurora Study: A Longitudinal Cohort Study, Kristen Nishimi, Sarah Linnstaedt, Thomas Neylan, Lauren Mckibben, Liz Marie Albertorio-Sáez, Ying Zhao, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Gari Clifford, Tanja Jovanovic, Laura Germine, Scott Rauch, John Haran, Alan Storrow, Paul Musey, Phyllis Hendry, Sophia Sheikh, Brittany Punches, Robert Swor, Jose Pascual, Mark Seamon, Elizabeth M Datner, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Paulina Sergot, Leon Sanchez, Steven Bruce, Steven Harte, Ronald Kessler, Karestan Koenen, Kerry Ressler, Samuel Mclean, Aoife O'Donovan May 2026

Inflammatory Markers In The Emergency Department And Ptsd Symptoms In The Aurora Study: A Longitudinal Cohort Study, Kristen Nishimi, Sarah Linnstaedt, Thomas Neylan, Lauren Mckibben, Liz Marie Albertorio-Sáez, Ying Zhao, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Gari Clifford, Tanja Jovanovic, Laura Germine, Scott Rauch, John Haran, Alan Storrow, Paul Musey, Phyllis Hendry, Sophia Sheikh, Brittany Punches, Robert Swor, Jose Pascual, Mark Seamon, Elizabeth M Datner, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Paulina Sergot, Leon Sanchez, Steven Bruce, Steven Harte, Ronald Kessler, Karestan Koenen, Kerry Ressler, Samuel Mclean, Aoife O'Donovan

Department of Emergency Medicine Faculty Papers

BACKGROUND: Systemic inflammation is hypothesized to contribute to post-traumatic stress disorder (PTSD) vulnerability. Few studies have examined inflammation shortly after trauma as a predictor of later PTSD symptoms. We examined whether inflammation from the emergency department (ED) post-trauma is associated with PTSD symptom severity over the following 6 months.

METHODS: Our sample included 742 AURORA participants, a longitudinal cohort of patients in 29 EDs across the United States after a traumatic stressor, followed up to 6 months. Plasma cytokines were assessed from a study blood draw in the ED: an inflammatory index (standardized sum of generally pro-inflammatory markers interleukin [IL]-6, …


Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling Of The Hdl Proteome And Impaired Reverse Cholesterol Transport, Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet May 2026

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling Of The Hdl Proteome And Impaired Reverse Cholesterol Transport, Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet

Physiology Faculty Publications

Over 10 million patients undergoing non-cardiac surgery each year face major cardiovascular complications within 30 days, many due to destabilized atherosclerotic plaques. Reverse cholesterol transport (RCT), driven by HDL and Apoa1, protects against plaque progression, but the effects of surgical inflammation on this pathway remain unclear. Using an abdominal laparotomy model in ApoE−/− mice on a Western diet, we isolated the impact of surgical inflammation without confounding blood loss. Surgery acutely impaired RCT and cholesterol efflux, with inflammatory remodeling of HDL marked by elevated SAA1/2 and reduced Apoa1. Plaques exhibited higher intracellular lipids, PLIN2 expression, and cleaved caspase-3, indicating …


Master Of Social Work Portfolio - Rooted In Relationship: A Journey Toward Integrated, Justice-Oriented Social Work Practice, Elisabeth Noel Marshall May 2026

Master Of Social Work Portfolio - Rooted In Relationship: A Journey Toward Integrated, Justice-Oriented Social Work Practice, Elisabeth Noel Marshall

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio represents my professional development throughout the Master of Social Work program at the University of Montana. Grounded in systems and ecological perspectives, trauma-informed practice, and the Just Practice framework, this work demonstrates the integration of clinical, mezzo, and macro social work practice across diverse settings, including therapeutic residential care, collegiate wellbeing, assisted living, and substance use treatment.

Through direct practice experiences, policy analysis, program evaluation, advocacy, and community engagement, this portfolio highlights the development of competencies aligned with the Council on Social Work Education’s Educational Policy and Accreditation Standards. Particular emphasis is placed on relationship-centered practice, justice-oriented advocacy, …


Professional Portfolio: Becoming A Justice-Centered Practitioner, Akemi Nakagawa May 2026

Professional Portfolio: Becoming A Justice-Centered Practitioner, Akemi Nakagawa

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This professional portfolio reflects my learning through this program, including the knowledge and skills I have developed, how my learning has been shaped by the people I have learned from and alongside, and what I will carry forward into future practice. I share my developing theoretical orientation that guides my thinking and practice, grounded predominantly in the Reproductive Justice framework, Critical Social Work, Janet Finn’s Just Practice framework, and by the work and wisdom of Paulo Freire–particularly his pedagogy of popular education.

This portfolio also reflects my ongoing development as a social worker who is committed to advancing intersectional justice …


Modalities Of Vision Restoration In Optic Neuropathies And Retinal Disease, Batsheva Rubin, Fabio Lavinsky, Rachel Cain, Ajay E. Kuriyan, Gadi Wollstein, Ronald Zambrano, Joel Schuman May 2026

Modalities Of Vision Restoration In Optic Neuropathies And Retinal Disease, Batsheva Rubin, Fabio Lavinsky, Rachel Cain, Ajay E. Kuriyan, Gadi Wollstein, Ronald Zambrano, Joel Schuman

Wills Eye Hospital Papers

Visual impairment affects over 250 million people globally and carries a significant psychosocial and economic burden. In recent years, rapid advancements in biomedical engineering and regenerative medicine have driven the development of innovative therapies aimed at restoring visual function. Here, we first provide an overview of the visual pathway, imaging modalities, and the psychosocial and economic burden of vision loss. Then we review four vision restoration approaches: gene and stem cell therapies, optogenetics, retinal prosthetic devices, and visual pathway electrical stimulation. For each therapeutic approach, the mechanism of action, clinical outcomes, adverse events, and current limitations are discussed. Stem cell …


Msw Portfolio: A Comprehensive Showcase Of Academic Work And Achievements, Emma Elizabeth Piskolich May 2026

Msw Portfolio: A Comprehensive Showcase Of Academic Work And Achievements, Emma Elizabeth Piskolich

Graduate Student Portfolios, Professional Papers, and Capstone Projects

Social work practice carries significant professional responsibility. As political systems evolve and new research continues to emerge, it is essential for practitioners to remain committed to ongoing learning and professional development. The nature of social work involves serving vulnerable and impacted populations, which requires that care be delivered with the profession’s core values at the forefront. My approach to social work practice is guided by several theoretical perspectives that shape my professional framework. I am particularly drawn to Empowerment Theory, Systems Theory, and Ecological Frameworks. In practice, I integrate these with the Strengths-Based Perspective, the Person-in-Environment perspective, and trauma-informed approaches …


Proximity Data And Social Networks: A Validation Study Of Two Models Of Mobile Dataloggers In The Semi-Fossorial And Social Rodent, Octodon Degus, L. D. Hayes, A. A. Maldonado-Chaparro, Jessica Morales Valenzuela, L. Platt, L. A. Ebensperger May 2026

Proximity Data And Social Networks: A Validation Study Of Two Models Of Mobile Dataloggers In The Semi-Fossorial And Social Rodent, Octodon Degus, L. D. Hayes, A. A. Maldonado-Chaparro, Jessica Morales Valenzuela, L. Platt, L. A. Ebensperger

Biology Faculty Works

The use of mobile dataloggers to gather proximity data has generated novel insights into the social network structure of animals. The performance of mobile dataloggers may be impacted by different environmental and social conditions. Thus, validation studies that account for species-specific habitat use and behavior are essential. We conducted a series of validation studies of two brands of mobile dataloggers (Gipsy6, Technosmart, Italy; ProxLog, IoSA, Belgium) on the semi-fossorial rodent, Octodon degus. First, we determined the sensitivity of both types of dataloggers to track position and closeness in different habitats (Experiments 1 and 2). To determine if the structure …


Sir Gawain, The Travelling Sun Of Medieval Literature, Leah H. Dascoli May 2026

Sir Gawain, The Travelling Sun Of Medieval Literature, Leah H. Dascoli

Undergraduate Honors Theses

This paper examines Sir Gawain’s roles in Medieval Arthurian literature from various geolinguistical regions in Europe. Starting in the twelfth century and extending to the late fifteenth century, there is a shift in literary legends that can be glimpsed through understanding what roles the authors of the Arthurian genre use for Sir Gawain.

By incorporating evidence within the text and supplementary evidence of historical context during which the stories were written and translated, this study seeks to create a discussion between the more obscure sources and more circulating sources in which Sir Gawain is a common factor. It argues that …


How To Fail At Faith, Olivia R. Bacon May 2026

How To Fail At Faith, Olivia R. Bacon

Honors Theses

How to Fail at Faith tells the story of Ruth, a girl in middle school who begins to doubt her faith in the Christian God. With these doubts come existential questions, fear, and, most strangely, a voice that narrates Ruth’s everyday activities inside her head. Ruth is scared this voice means she is only a character inside a story, but is even more scared to tell her parents about her internal struggles. As Ruth grapples with her faith, this “narrator” becomes a tangible support amid uncertainties. Ruth surrenders to trusting God after fighting her doubts, and discovers that her mysterious …


Learning Through Play: The Effects Of Play-Based Instruction On Literacy Development, Jherica Goodgame May 2026

Learning Through Play: The Effects Of Play-Based Instruction On Literacy Development, Jherica Goodgame

Honors Theses

This thesis explores the role of play-based learning in early literacy development, emphasizing its impact on student engagement, executive functioning, and overall academic success. Drawing from research and personal experience, it argues that play is not separate from learning but a critical component of it. This thesis also highlights the benefits of play for diverse learners and examines the challenges teachers face in implementing play-based instruction. It provides numerous examples of play-based instruction practiced in a real classroom setting with 17 students who are varying from early kindergarten to late kindergarten levels. This thesis seeks to demonstrate the importance of …


What Do We Owe A Drowning Coast? Examining Louisiana's Coastal Crisis Through The Lens Of Environmental Justice, Owen M. Plaisance May 2026

What Do We Owe A Drowning Coast? Examining Louisiana's Coastal Crisis Through The Lens Of Environmental Justice, Owen M. Plaisance

Honors Theses

This thesis argues that human contributions to Louisiana’s coastal land loss constitute a form of environmental injustice that cannot be adequately addressed through frameworks focused solely on aggregate welfare or distributive fairness. While utilitarian and Rawlsian approaches offer important insights, both are limited in capturing the full scope of harm caused by environmental degradation. In coastal Louisiana, land loss undermines not only economic resources and physical security but also the substantive freedoms required for individuals and communities to live meaningful and culturally rooted lives, while disrupting ecological systems and non-human flourishing. To address these limitations, the thesis develops the Capabilities …


A Quality Improvement Initiative Evaluating Factors Influencing Patient Experience With Virtual Reality During Awake​ Interventional Radiology Procedures, Quynh Dao-Payne May 2026

A Quality Improvement Initiative Evaluating Factors Influencing Patient Experience With Virtual Reality During Awake​ Interventional Radiology Procedures, Quynh Dao-Payne

Doctoral Projects

Procedural anxiety and pain are common among pediatric patients undergoing awake interventional radiology (IR) procedures and may negatively affect patient comfort, cooperation, and overall patient experience. Virtual reality (VR) has emerged as a promising nonpharmacologic intervention to reduce anxiety and improve patient-centered outcomes. The purpose of this quality improvement project was to evaluate patient-reported experiences and perceived outcomes associated with VR use during awake pediatric IR procedures at Children’s Hospital Los Angeles.​ A qualitative descriptive quality improvement design was utilized. Twenty pediatric​ patients ages 10–21 years undergoing awake IR procedures with VR as part of standard clinical​ care completed structured …


"En Papel,” Not In Practice: Indigenous Autonomy And The Structural Barriers To Land And Resource Control In Bolivia, Andrew F. Purcell May 2026

"En Papel,” Not In Practice: Indigenous Autonomy And The Structural Barriers To Land And Resource Control In Bolivia, Andrew F. Purcell

Honors Theses

This thesis examines why Bolivia’s 2009 plurinational constitution—despite its strong recognition of Indigenous autonomy, collective territory, and prior consultation—often produces rights that remain “en papel” rather than in practice. Based on one month of fieldwork in Tumupasa, Chojasivi, La Paz, El Alto, and Santa Cruz, the study draws on interviews, participant observation, and NGO documents to analyze the structural barriers that prevent constitutional guarantees from becoming enforceable governance tools. This gap between recognition and implementation structures the central research question: why do Bolivia’s constitutional and legal protections for indigenous land and resource rights function as symbolic guarantees rather than enforceable …


Windows Of Developmental Susceptibility To Tetrahydrocannabivarin (Thcv) Reveal Stage-Dependent Morphological And Biological Effects, Mirielle Clayton May 2026

Windows Of Developmental Susceptibility To Tetrahydrocannabivarin (Thcv) Reveal Stage-Dependent Morphological And Biological Effects, Mirielle Clayton

Honors Theses

Tetrahydrocannabivarin (THCV), a minor cannabinoid found in Cannabis sativa, is gaining attention for its potential therapeutic applications, yet its effects on early development remain poorly understood. This study investigated how the timing of THCV exposure influences morphological, behavioral, and bioaccumulation outcomes in zebrafish (Danio rerio) embryos. Embryos were exposed to 2 μM THCV during discrete developmental windows (6–30, 30–54, 54–78, 78–102) and continuous 6–102 hours post-fertilization (hpf), designed to model early stages of human gestation. Behavioral analysis using a larval photomotor response assay revealed significant reductions in locomotor activity during dark phases, with the strongest hypoactivity observed …


Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson May 2026

Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson

Faculty, Staff and Student Publications

Only recently have human postmortem brain studies of differential gene expression (DGE) associated with opioid overdose death (OOD) been published; sample sizes from these studies have been modest (N = 40-153). To increase statistical power to identify OOD-associated genes, we leveraged human prefrontal cortex RNA-seq data from four independent OOD studies and conducted a transcriptome-wide DGE meta-analysis (N = 272). Using a unified gene expression data processing and analysis framework across studies, we meta-analyzed 20, 098 genes and found 335 significant differentially expressed genes (DEGs) by OOD status (false discovery rate <  0.05). Of these, 66 DEGs were among the list of 303 genes reported as OOD-associated in prior prefrontal cortex molecular studies (e.g., genes/gene families OPRK1, NPAS4, DUSP, EGR). The remaining 269 DEGs were not previously reported (e.g., NR4A2, SYT1, HCRTR2, BDNF). There was little evidence of genetic drivers for the observed differences in gene expression between opioid addiction cases and controls. Enrichment analyses for the DEGs across molecular pathway and biological process databases highlight an interconnected set of genes and pathways linked to orexin and tyrosine kinase receptors through MEK/ERK/MAPK signaling to affect neuronal plasticity.


Progressive Cardiac Phenotypes And Reduced Reversibility From Long-Term Cugexp Rna Expression In A Dm1 Mouse Model, Rong-Chi Hu, Mohammadreza Tabary, Xander Ht Wehrens, Thomas A Cooper May 2026

Progressive Cardiac Phenotypes And Reduced Reversibility From Long-Term Cugexp Rna Expression In A Dm1 Mouse Model, Rong-Chi Hu, Mohammadreza Tabary, Xander Ht Wehrens, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is caused by an expanded CTG repeat in the DMPK gene, resulting in mutant transcripts that form expanded CUG (CUGexp) RNA foci and sequester muscleblind-like (MBNL) RNA-binding proteins. DM1 is multisystemic, with progressive worsening of disease manifestations in affected tissues. Disease progression is attributed to somatic expansion of the CTG repeats with age, resulting in production of CUGexp RNA with enhanced intrinsic toxicity due to increased MBNL sequestration. To determine the degree to which cardiac disease progression can occur independently of repeat expansion, we used a transgenic DM1 mouse model with inducible heart-specific expression of …


Enhancing Psychiatry Residents’ Knowledge And Comfort With Clozapine Prescribing Through Educational Interventions, Christopher Stewart, Alexander Hunter, Faith Franzwa, Quan Huynh, Jennifer Stettler, Nauman Ashraf, Dawny M. Barnhart May 2026

Enhancing Psychiatry Residents’ Knowledge And Comfort With Clozapine Prescribing Through Educational Interventions, Christopher Stewart, Alexander Hunter, Faith Franzwa, Quan Huynh, Jennifer Stettler, Nauman Ashraf, Dawny M. Barnhart

Student Publications

Introduction: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia but remains underutilized due to safety concerns and monitoring complexity. Recent discontinuation of the Clozapine Risk Evaluation and Mitigation Strategy (REMS) program reduced regulatory barriers but shifted responsibility for monitoring to clinicians. Psychiatry residents may lack adequate training and confidence to prescribe clozapine safely in this new context. The goal of this study is to evaluate the impact of a structured educational intervention on psychiatry residents’ knowledge of clozapine prescribing and management.

Methods: This study was a single-institution quality improvement study using a pre-post design. Participants were psychiatry residents from …