Digital Commons Network^™

Where Island Studies Meets Mobility Studies In Literary And Cultural Studies: Part Two, Maria Luisa T. Reyes, Luisa L. Gomez

Kritika Kultura

This article describes the second part of the special section to highlight how the essays provide yet a unique perspective on the interconnections between island studies and mobility studies. From an examination of canonical works from Tatsuhiro Oshiro’s The Cocktail Party to an investigation of more contemporary materials found on media such as YouTube and a Disney film, this article aims to examine how the featured essays closely study the concept of “islands” and how its interconnection with and influence on mobility.

Rituals And Magic On The Transition Of Sacredness In Folk Religion In Central Vietnam, Dang Huu Nguyen

Kritika Kultura

This article examines the dynamics of sacredness in Central Vietnamese folk religion. It utilizes a qualitative approach, specifically ethnographic fieldwork and in-depth interviews in the community of Danang estuary in Central Vietnam, to study rituals and magic, specifically those involved in purifying, de-sanctifying, and re-sanctifying religious artifacts. The findings of this study demonstrate that the concept of sacredness is not fixed; rather, it continuously fluctuates between states of sanctification and de-sanctification. Additionally, the dynamics of the sacred is subject to change and is attributed with different values when transferred across cultural contexts. Based on these observations, this article emphasizes the …

Photographic Power: Scenes From The United States And The Philippines, Vicente L. Rafael

Kritika Kultura

This essay takes its inspiration from a series of addresses given by the former slave and radical abolitionist Frederick Douglass. Douglass hailed the promise of photography to bring forth democratic modes of representation. He saw in photography the power to bring distances up close and level social hierarchies by revealing the common humanity of those below with those above. Douglass, however, hedged his optimistic view. He saw that the “vast power” of photography also came with great danger. It can reveal truth but it can also foster error depending on “the master we obey.” It is this double-edged power of …

Give My Heart Ease: Filiality And Responsibility In Clarissa In Light Of Levinasian And Confucian Ethics, Ying Xiong

Kritika Kultura

Much has been said about the elements of plot, allegorical allusions, and the Christian design underlying character tendencies in Samuel Richardson’s Clarissa. That said, few scholars notice the intricate mechanism of filiality and responsibility that constantly functions in Clarissa’s ethical quest. Arguably, there are two categories of filiality in Clarissa, one being Levinasian, which always responds to the absolute singularity of the Other, and the other being Confucian, which demands responsibility to a totality. Judging from her struggle, one surmises that two ethical principles colliding within Clarissa’s mind as she responds to her relations mainly arise from her Levinasian sense …

Green Buddhism And W. S. Merwin’S Eco-Poetry, Jiyong Geng, Jie Zhang

Kritika Kultura

This article explores the profound influence of Buddhist environmental thought on the poetry of W.S. Merwin. It discusses how Merwin integrates Buddhist philosophies such as interdependent arising (pratītya-samutpāda), emptiness (śūnyatā), non-self (anātman), compassion (karunā), and the concept of Buddha nature into his poetic work, highlighting themes such as ecological interconnectedness, the rejection of anthropocentrism, and the intrinsic value of nature. The article examines how Merwin’s use of these themes not only enriches his poetic expression but also contributes to the broader discourse on green Buddhism, bridging the gap between human experience and ecological consciousness.

Front Matter, Kritika Kultura Kritika Kultura

Kritika Kultura

No abstract provided.

Editor's Introduction, Vincenz Serrano

Kritika Kultura

No abstract provided.

The Beacon, October 4, 2024, Beacon Staff

The Beacon, 2024-2025

An exciting Homecoming weekend ahead; Another new(ish) face on NW's campus; A new twist on the children's show; Review of "Transformers One" movie; Buble adds to his popular hits; Honors students discover Greece; Students flock to local flower farm; Homecoming events welcome alumni; Raider Homecoming Crossword Puzzle; New costume studio manager; The true cost of cheap clothing; Is your local music scene dead?; Raider Esports prioritizes teamwork; Homecoming weekend filled with sports; Two Raiders showcase excellence on the field; Trivia night is off to a good start; Steggy Keggy is back and better than ever;

Biology Of Aproida Balyi Pascoe, 1863 (Coleoptera: Chrysomelidae: Cassidinae: Aproidini) On Its Host Plant, Eustrephus Latifolius R. Br. Ex Ker-Gawl (Asparagaceae) In Australia, Caroline Simmrita Chaboo, Vivian E., Mariana Campos, Geoff B. Monteith

Insecta Mundi

Within the leaf-beetle subfamily Cassidinae (Coleoptera: Chrysomelidae), Aproida Pascoe, 1863 (Aproidini) from Australia has been considered a transitional genus between mining cassidines (“hispines”) and exophagous cassidines (“tortoise beetles”). To illuminate this transition, a detailed study was conducted over one year of the biology of Aproida balyi Pascoe, 1863 on the host plant, Eustrephus latifolius R. Br. ex Ker-Gawl (Asparagaceae). Distribution maps of the host plant and three Aproida species are provided. The life cycle of A. balyi comprises single eggs in a foamy ootheca, three larval instars that feed openly, a pupa suspended from the larva III exuvia, and …

Oregon State Rank Assessment For Nerite Ramshorn (Vorticifex Neritoides), Jesse Laney

Institute for Natural Resources Publications

Oregon state conservation status assessment for nerite ramshorn (Vorticifex neritoides) using NatureServe methodology, 2024.

Identification Of An Ionic Mechanism For Erα-Mediated Rapid Excitation In Neurons, Meng Yu, Na Yin, Bing Feng, Peiyu Gao, Kaifan Yu, Hesong Liu, Hailan Liu, Yongxiang Li, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Longlong Tu, Jonathan C. Bean, Qingzhuo Liu, Yue Deng, Yuxue Yang, Junying Han, Sanika V. Jossy, Megan L. Burt, Huey Zhong Wong, Yongjie Yang, Benjamin R. Arenkiel, Yang He, Shaodong Guo, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Zhao Wang, Chunmei Wang, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

The major female ovarian hormone, 17β-estradiol (E2), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E2, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα. Clic1-mediated currents can be enhanced by E2 and reduced by its depletion. In addition, Clic1 currents are required to mediate the E2-induced rapid excitations in multiple brain ERα …

Proceedings Of The 2022 “Lifestyle Intervention For Epilepsy (Life)” Symposium Hosted By Cleveland Clinic, Martha Sajatovic

Faculty Scholarship

Lifestyle interventions are strategies used to self-manage medical conditions, such as epilepsy, and often complement traditional pharmacologic and surgical therapies. The need for integrating evidence-based lifestyle interventions into mainstream medicine for the treatment of epilepsy is evident given that despite the availability of a multitude of treatments with medications and surgical techniques, a significant proportion of patients have refractory seizures, and even those who are seizure-free report significant adverse effects with current treatments. Although the evidence base for complementary medicine is less robust than it is for traditional forms of medicine, the evidence to date suggests that several forms of …

Volume Cxliv, Number 2, October 4, 2024, Lawrence University

The Lawrentian

No abstract provided.

Oregon State Rank Assessment For Mann's Mollusk-Eating Ground Beetle (Scaphinotus Mannii), Jesse Laney

Institute for Natural Resources Publications

Oregon state conservation status assessment for Mann's mollusk-eating ground beetle (Scaphinotus mannii) using NatureServe methodology, 2024.

Reactions To The Mpox Vaccine Regarding Absences And Disruption Of Daily Activities In The United States, Robert Rossi

Walden Dissertations and Doctoral Studies

Since its global outbreak in 2022, the monkeypox (Mpox) virus has infected over 32,000 individuals in the United States, resulting in approximately 58 deaths. Although the JYNNEOS vaccine is effective at disease prevention, it has also been found to cause side effects, such as a disruption in daily activities and/or attendance at work or school. This quantitative, cross-sectional study was conducted to investigate whether differences existed in reactions to the Mpox vaccine, using secondary data from the Centers for Disease Control and Prevention’s V-safe Mpox survey. The two dependent variables were work/school absenteeism and disruption of daily activities, and the …

Biologic And Clinical Analysis Of Childhood Gamma Delta T-All Identifies Lmo2/Stag2 Rearrangements As Extremely High Risk, Shunsuke Kimura, Chun Shik Park, Lindsey E Montefiori, Ilaria Iacobucci, Petri Pölönen, Qingsong Gao, Elizabeth D Arnold, Andishe Attarbaschi, Anthony Brown, Barbara Buldini, Kenneth J Caldwell, Yunchao Chang, Chelsey Chen, Cheng Cheng, Zhongshan Cheng, John Choi, Valentino Conter, Kristine R Crews, Hester A De Groot-Kruseman, Takao Deguchi, Mariko Eguchi, Hannah E Muhle, Sarah Elitzur, Gabriele Escherich, Burgess B Freeman, Zhaohui Gu, Katie Han, Keizo Horibe, Toshihiko Imamura, Sima Jeha, Motohiro Kato, Kean H Chiew, Tanya Khan, Michal Kicinski, Stefan Köhrer, Steven M Kornblau, Rishi S Kotecha, Chi-Kong Li, Yen-Chun Liu, Franco Locatelli, Selina M Luger, Elisabeth M Paietta, Atsushi Manabe, Hanne V Marquart, Riccardo Masetti, Mellissa Maybury, Pauline Mazilier, Jules P P Meijerink, Sharnise Mitchell, Takako Miyamura, Andrew S Moore, Koichi Oshima, Katarzyna Pawinska-Wasikowska, Rob Pieters, Mollie S Prater, Shondra M Pruett-Miller, Ching-Hon Pui, Chunxu Qu, Michaela Reiterova, Noemi Reyes, Kathryn G Roberts, Jacob M Rowe, Atsushi Sato, Kjeld Schmiegelow, Martin Schrappe, Shuhong Shen, Szymon Skoczeń, Orietta Spinelli, Jan Stary, Michael Svaton, Masatoshi Takagi, Junko Takita, Yanjing Tang, David T Teachey, Paul G Thomas, Daisuke Tomizawa, Jan Trka, Elena Varotto, Tiffaney L Vincent, Jun J Yang, Allen E J Yeoh, Yinmei Zhou, Martin Zimmermann, Hiroto Inaba, Charles G Mullighan

Faculty, Staff and Student Publications

Acute lymphoblastic leukemia expressing the gamma delta T-cell receptor (γδ T-ALL) is a poorly understood disease. We studied 200 children with γδ T-ALL from 13 clinical study groups to understand the clinical and genetic features of this disease. We found age and genetic drivers were significantly associated with outcome. γδ T-ALL diagnosed in children under 3 years of age was extremely high-risk and enriched for genetic alterations that result in both LMO2 activation and STAG2 inactivation. Mechanistically, using patient samples and isogenic cell lines, we show that inactivation of STAG2 profoundly perturbs chromatin organization by altering enhancer-promoter looping, resulting in …

Tissue-Agnostic Targeting Of Neurotrophic Tyrosine Receptor Kinase Fusions: Current Approvals And Future Directions, Mohamed A Gouda, Kyaw Z Thein, David S Hong

Faculty, Staff and Student Publications

NTRK fusions are oncogenic drivers for multiple tumor types. Therefore, the development of selective tropomyosin receptor kinase (TRK) inhibitors, including larotrectinib and entrectinib, has been transformative in the context of clinical management, given the high rates of responses to these drugs, including intracranial responses in patients with brain metastases. Given their promising activity in pan-cancer cohorts, larotrectinib and entrectinib received U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) approval for tissue-agnostic indications in patients with advanced solid tumors harboring NTRK fusions. The safety profiles for both drugs are quite manageable, although neurotoxicity driven by the on-target inhibition …

Cd28 Costimulation Augments Car Signaling In Nk Cells Via The Lck/Cd3Ζ/Zap70 Signaling Axis, Sunil Acharya, Rafet Basar, May Daher, Hind Rafei, Ping Li, Nadima Uprety, Emily Ensley, Mayra Shanley, Bijender Kumar, Pinaki P Banerjee, Luciana Melo Garcia, Paul Lin, Vakul Mohanty, Kun H Kim, Xianli Jiang, Yuchen Pan, Ye Li, Bin Liu, Ana K Nunez Cortes, Chenyu Zhang, Mohsen Fathi, Ali Rezvan, Melisa J Montalvo, Sophia L Cha, Francia Reyes-Silva, Rejeena Shrestha, Xingliang Guo, Kiran Kundu, Alexander Biederstädt, Luis Muniz-Feliciano, Gary M Deyter, Mecit Kaplan, Xin R Jiang, Enli Liu, Antrix Jain, Janos Roszik, Natalie W Fowlkes, Luisa M Solis Soto, Maria G Raso, Joseph D Khoury, Pei Lin, Francisco Vega, Navin Varadarajan, Ken Chen, David Marin, Elizabeth J Shpall, Katayoun Rezvani

Faculty, Staff and Student Publications

Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR-engineered natural killer (NK) cells remains largely unexplored. Here, we evaluated the impact of various costimulatory domains on CAR-NK cell activity, using a CD70-targeting CAR. We found that CD28, a costimulatory molecule not inherently present in mature NK cells, significantly enhanced the antitumor efficacy and long-term cytotoxicity of CAR-NK cells both in vitro and in multiple xenograft models of hematologic and solid tumors. Mechanistically, …

Distinct Visual Processing Networks For Foveal And Peripheral Visual Fields, Jie Zhang, Huihui Zhou, Shuo Wang

2020-Current year OA Pubs

Foveal and peripheral vision are two distinct modes of visual processing essential for navigating the world. However, it remains unclear if they engage different neural mechanisms and circuits within the visual attentional system. Here, we trained macaques to perform a free-gaze visual search task using natural face and object stimuli and recorded a large number of 14588 visually responsive units from a broadly distributed network of brain regions involved in visual attentional processing. Foveal and peripheral units had substantially different proportions across brain regions and exhibited systematic differences in encoding visual information and visual attention. The spike-local field potential (LFP) …

A Multivariate Approach To Assessing Landscape Structure Effects On Wildlife Crossing Structure Use, Thomas J. Yamashita, Humberto L. Perotto-Baldivieso, David B. Wester, Kevin W. Ryer, Richard J. Kline, Michael E. Tewes, John H. Young Jr., Jason V. Lombardi

School of Earth, Environmental, & Marine Sciences Faculty Publications

Background

Complexity in landscape structure is often assessed using individual metrics related to ecological processes. However, this rarely incorporates important relationships among metrics and may miss landscape structure effects. Multivariate statistics provide techniques for assessing overall landscape structure effects. We assessed how multivariate statistics could be used to connect landscape structure with an ecological process [bobcat (Lynx rufus) wildlife crossing structure (WCS) use]. We tested how landscape structure at WCS sites compared to the surrounding landscape and how structure affected detections at WCS sites. Our study was conducted in Cameron County, Texas, USA where WCSs are in various …

The Impact Of Land Use And Land Cover Change On Water Quality In Lake Victoria Catchment: A Case Study Of Nkangabile River At Nyegezi Bay, Tanzania, Charles A Mashafi, Makemie Mabula, Masumbuko Semba, Charles N Ezekiel

Tanzania Journal of Science

Understanding the trends and impacts of anthropogenic activities in the water basins and catchments is key to the effective management and conservation of aquatic environments. This study analyses the land use and land cover (LULC) changes in the Nkangabile catchment and their impacts on water quality in the Nyegezi Bay of Lake Victoria, Tanzanian side. GIS and Remote sensing techniques were used to analyze the multi-temporal changes in LULC that occurred in the past 30 years from 1983 to 2013, split into four epochs of 10-year intervals. The changes in LULC were analyzed using image differencing and cross-tabulation for pairwise …

Cell Type-Specific Epigenetic Priming Of Gene Expression In Nucleus Accumbens By Cocaine, Philipp Mews, Yentl Van Der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, Eric J Nestler

2020-Current year OA Pubs

A hallmark of addiction is the ability of drugs of abuse to trigger relapse after periods of prolonged abstinence. Here, we describe an epigenetic mechanism whereby chronic cocaine exposure causes lasting chromatin and downstream transcriptional modifications in the nucleus accumbens (NAc), a critical brain region controlling motivation. We link prolonged withdrawal from cocaine to the depletion of the histone variant H2A.Z, coupled with increased genome accessibility and latent priming of gene transcription, in D1 dopamine receptor-expressing medium spiny neurons (D1 MSNs) that relate to aberrant gene expression upon drug relapse. The histone chaperone ANP32E removes H2A.Z from chromatin, and we …

Oregon State Rank Assessment For Yuma Myotis (Myotis Yumanensis), Jesse Laney

Institute for Natural Resources Publications

Oregon state conservation status assessment for Yuma myotis (Myotis yumanensis) using NatureServe methodology, 2024.

Identification Of An Ionic Mechanism For Erα-Mediated Rapid Excitation In Neurons, Meng Yu, Na Yin, Bing Feng, Peiyu Gao, Kaifan Yu, Hesong Liu, Hailan Liu, Yongxiang Li, Olivia Z Ginnard, Kristine M Conde, Mengjie Wang, Xing Fang, Longlong Tu, Jonathan C Bean, Qingzhuo Liu, Yue Deng, Yuxue Yang, Junying Han, Sanika V Jossy, Megan L Burt, Huey Zhong Wong, Yongjie Yang, Benjamin R Arenkiel, Yang He, Shaodong Guo, Pierre Gourdy, Jean-Francois Arnal, Francoise Lenfant, Zhao Wang, Chunmei Wang, Yanlin He, Yong Xu

Faculty, Staff and Students Publications

The major female ovarian hormone, 17β-estradiol (E2), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E2, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα. Clic1-mediated currents can be enhanced by E2 and reduced by its depletion. In addition, Clic1 currents are required to mediate the E2-induced rapid excitations in multiple brain ERα …

Terminal Differentiation Precedes Functional Circuit Integration In The Peduncle Neurons In Regenerating Hydra Vulgaris, Alondra Escobar, Soonyoung Kim, Abby S Primack, Guillaume Duret, Celina E Juliano, Jacob T Robinson

Faculty, Staff and Students Publications

Understanding how neural circuits are regenerated following injury is a fundamental question in neuroscience. Hydra is a powerful model for studying this process because it has a simple neural circuit structure, significant and reproducible regenerative abilities, and established methods for creating transgenics with cell-type-specific expression. While Hydra is a long-standing model for regeneration and development, little is known about how neural activity and behavior is restored following significant injury. In this study, we ask if regenerating neurons terminally differentiate prior to reforming functional neural circuits, or if neural circuits regenerate first and then guide the constituent naive cells toward their …

Vol. 30, No. 7 - Whole No. 155, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 30, No. 4 - Whole No. 153, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Post-Soviet National Memory In Kazakhstan, Iona Volynets

Chronos

When the Soviet Union collapsed and was replaced by fifteen independent republics, each country began to cultivate a unique perspective on their national history, especially the Soviet period. However, Western study of post-Soviet national memory is largely limited to a focus on Russia and the Baltics states. Less studied is the way in which the Caucasian and Central Asian states have framed their national histories vis-a-vis the USSR. This paper takes Kazakhstan as a case study and shows how this country has processed, displayed, and interpreted Soviet history in its museums.

Tongue-In-Cheek Dictionary Of Birding Terms, Eirik A. T. Blom

Maryland Birdlife

No abstract provided.

Front Matter, Maryland Birdlife

Maryland Birdlife

No abstract provided.