Digital Commons Network^™

Cryo-Em Analysis Of Pseudomonas Phage Pa193 Structural Components, Stephano M. Iglesias, Chun-Feng Hou, Johnny Reid, Evan Schauer, Renae Geier, Angela Soriaga, Lucy Sim, Lucy Gao, Julian Whitelegge, Pierre Kyme, Deborah Birx, Sebastien Lemire, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

The World Health Organization has designated Pseudomonas aeruginosa as a critical pathogen for the development of new antimicrobials. Bacterial viruses, or bacteriophages, have been used in various clinical settings, commonly called phage therapy, to address this growing public health crisis. Here, we describe a high-resolution structural atlas of a therapeutic, contractile-tailed Pseudomonas phage, Pa193. We used bioinformatics, proteomics, and cryogenic electron microscopy single particle analysis to identify, annotate, and build atomic models for 21 distinct structural polypeptide chains forming the icosahedral capsid, neck, contractile tail, and baseplate. We identified a putative scaffolding protein stabilizing the interior of the capsid 5-fold …

Finding The Right Mentor & Maintaining The Relationship Through Key Conversations, Adebisi Alli, Ankita Sagar, Eliza Lo Chin, Paulina Awuah-Saadiq, Susan Thompson Hingle

Journal of Wellness

No abstract provided.

Cy Pres Silliness: Remedies That Do Not Remediate The Harm, Phil Pillari

Northwestern University Law Review

Class actions play an important role in civil litigation, but they suffer from a serious problem. No matter how many plaintiffs are in the class, the individual claims are often miniscule, which can make distributing the inevitable settlement futile. Very few people make a claim, and it often costs more to mail the check than the check is worth. To solve this problem, Steven Shepherd proposed importing the cy pres doctrine (a trusts and estates device that allows courts to rewrite an unenforceable trust) into the class actions context. Shepherd’s framework instructs courts to devise the next best alternative for …

Plasma Proteomic Biomarkers In Alzheimer's Disease And Cardiovascular Disease: A Longitudinal Study, Laurie A. Theeke, Ying Liu, Silas Wang, Xingguang Luo, R Osvaldo Navia, Danqing Xiao, Chun Xu, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

The co-occurrence of Alzheimer's disease (AD) and cardiovascular diseases (CVDs) in older adults highlights the necessity for the exploration of potential shared risk factors. A total of 566 adults were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including 111 individuals with AD, 383 with mild cognitive impairment (MCI), and 410 with CVD. The multivariable linear mixed model (LMM) was used to investigate the associations of AD and CVD with longitudinal changes in 146 plasma proteomic biomarkers (measured at baseline and the 12-month follow-up). The LMM showed that 48 biomarkers were linked to AD and 46 to CVD ( …

Biodiesel Recycling From Used Cooking Oil And Grease, Hyeong-Gyu Choi

Mountain Plains Business Conference

The proposed idea is to establish a biodiesel fuel operation by recycling used cooking oil, partnering with regional restaurants. Biodiesel can be produced by combining alcohol with vegetable oils, animal fats, or recycled cooking grease. Sourcing biodiesel from used vegetable oil and cooking grease promotes sustainability by minimizing waste and environmental risks, while potentially reducing health hazards. I have partnered with a firm that has achieved a highly efficient production state, but the company is struggling to recruit local restaurants willing to become supply chain partners. We seek ideas on how to recruit local restaurants interested in joining its sustainability …

Clustered Setation On The Pedipalps Of Buthid Scorpions (Scorpiones: Buthidae), Graeme Lowe, Victoria Tang

Euscorpius

Chaetotaxy of the external pedipalp femur and distal ventral pedipalp movable finger was studied in 120 species, 69 genera and 17 families of scorpions. Setation was generally denser in the ‘Buthus’ group, a major arid-adapted buthid lineage distributed across Palearctic deserts. On the external femur, macrosetae formed a prominent cluster, the ‘distal external macrosetal cluster’ (DEMC); on the distal ventral movable finger they formed a dense patch, the ‘distal ventral macrosetal cluster’ (DVMC). In other buthids and non-buthids, the DEMC and DVMC were mostly absent, except in a few arid-adapted genera. Relative setation densities of DEMC and DVMC in different …

Friendship Rock Hill Church Council Minutes 2018-2024, Friendship United Methodist Church, Rock Hill

Methodist Local Church Records

No abstract provided.

Loving Beyond The Human: Anthropocentric And Anthropomorphic Values In The Loving And Hating Of Nonhuman Animals, Stephanie M. Takata-Struble

Between the Species

I offer an account of the centrality of values to moral experience and the ways in which value disorder characterizes our relationships with nonhuman animals. To do this, I first provide an account of Max Scheler’s phenomenology of values, including the hierarchy of values, and loving and hating as value orientations. Drawing on this account, I map out two value orientations specific to our relationships with animals—anthropocentrism and anthropomorphism. Within these two value orientations, I detail three specific forms of valuation—gustatory, cosmetic, and anthropomorphic substitution—which demonstrate the ways in which people’s naïve love for the nonhuman animal is often, phenomenologically, …

Synergistic Efficacy Of Zno Quantum Dots, Ag Nps, And Nitazoxanide Composite Against Multidrug-Resistant Human Pathogens As New Trend Of Revolutionizing Antimicrobial Treatment, Islam Gomaa

Nanotechnology Research Centre

No abstract provided.

Histological Characterization Of Larch Mountain Salamander (Plethodon Larselli) Head Glands, Jaxon Hopkins, Nancy Staub

CURCI Student Research

In salamanders, successful reproduction requires communication. Most male salamanders communicate to the female during courtship via a gland on their chin, called the mental gland. The sexually dimorphic mental gland in the dermis of the lower jaw is typical in males of species in the family Plethodontidae and is considered ancestral to the family (Sever et al. 2016). The mental gland consists of an aggregate of modified granular glands (MGGs) that produce pheromones (Houck and Sever, 1994; Rupp and Sever, 2018). During courtship, pheromones secreted from mental glands are delivered to the female through head rubbing and biting (Houck and …

Duration, Cost, And Escalation Of Care Events For Physical Therapy Management Of Low Back Pain In Service Members With Limb Loss, Brittney M. Gunterstockman, Brad D. Hendershot, Joseph Kakyomya, Charity G. Patterson, Christopher L. Dearth, Shawn Farrokhi

Physical Therapy Faculty Articles and Research

Introduction Physical therapy (PT) is recommended as a primary treatment for low back pain (LBP), a common and impactful musculoskeletal condition after limb loss. The purpose of this brief report is to report the duration and cost of PT care, and subsequent escalation of care events, for LBP in service members with and without limb loss. Materials and Methods This was a retrospective cohort, descriptive study. Service members with and without limb loss (matched) who received PT for LBP at a military treatment facility from 2015 to 2017 were included. Duration of PT care, number of PT visits, and escalation …

Fire And Ant Interactions Mediated By Honeydew And Extrafloral Nectar In An Australian Tropical Savanna, Fernanda M. P. Oliveira, Carlos H. F Silva, Melinda L. Moir, Inara R. Leal, Alan N. Andersen

Natural Resources Research Articles

Fire is a major disturbance affecting ecosystems globally, but its impact on mutualisms has received minimal attention. Here, we use a long-term field experiment to investigate the impact of different fire regimes on globally important ant–honeydew and ant–extrafloral nectar (EFN) mutualistic interactions in an Australian tropical savanna. These interactions provide ants with a key energy source, while their plant and hemipteran hosts receive protection services. We examined ant interactions on species of Eucalyptus (lacking EFNs) and Acacia (with EFNs) in three replicate plots each of burning every 2 and 3 years early in the dry season, burning late in the …

Increased Myositis And Possible Myocarditis In Melanoma Patients Treated With Immune Checkpoint Inhibitors In The Covid-19 Era, Allison L. Gradone, Vincent T Ma, Alexi Vasbinder, Leslie A Fecher, Sarah Yentz, Salim S Hayek, Christopher D Lao

Department of Medical Oncology Faculty Papers

BACKGROUND: Immune checkpoint inhibitor (ICI)-mediated myocarditis results in significant morbidity and mortality. At our institution, we noted an increased incidence of ICI-mediated myocarditis cases, leading to further investigation in our database of advanced melanoma patients treated with ICI therapy.

METHODS: A single-center, retrospective cohort analysis of patients with advanced melanoma identified cases of ICI-mediated myocarditis and myositis.

RESULTS: 366 patients with advanced melanoma received a dose of ICI from September 2014 to October 2019. Of these patients, there were 0 cases of ICI-mediated myocarditis (0%, 95% CI 0%-1.0%) and 2 cases of ICI-mediated myositis (0.55%, 95% CI 0.07%-1.96%). From November …

The Biad Standards: Recommendations For Archaeological Data Publication And Insights From The Big Interdisciplinary Archaeological Database, Samantha S. Reiter, Robert Staniuk, Jan Kolář, Jelena Bulatović, Helene Agerskov Rose, Natalia E. Ryabogina, Claudia Speciale, Nicoline Schjerven, Bettina Schulz Paulsson, Victor Yan Kin Lee, Elisabetta Canteri, Alice Revill, Fredrik Dahlberg, Serena Sabatini, Karin M. Frei, Fernando Racimo, Maria Ivanova-Bieg, Wolfgang Traylor, Emily J. Kate, Eve Derenne, Lea Frank, Jessie Woodbridge, Ralph Fyfe, Stephen Shennan, Kristian Kristiansen, Mark G. Thomas, Adrian Timpson

School of Geography, Earth and Environmental Sciences

This article presents a series of recommendations for the publication of archaeological data, to improve their usability. These 12 recommendations were formulated by archaeological data experts who mined thousands of publications for different data types (including funerary practices, accelerator mass spectrometry dating, stable isotopes, zooarchaeology, archaeobotany and pathologies) during the initial construction of the Big Interdisciplinary Archaeological Database (BIAD). We also include data harmonisation vocabularies utilised for the integration of data from different recording systems. The case studies we cite to illustrate the recommendations are grounded in examples from the published literature and are presented in a problem/solution format. Though …

25-Hydroxycholesterol Promotes Brain Cytokine Production And Leukocyte Infiltration In A Mouse Model Of Lipopolysaccharide-Induced Neuroinflammation, Johnathan Romero, Danira Toral-Rios, Jinsheng Yu, Steven M Paul, Anil G Cashikar

2020-Current year OA Pubs

Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and, in response to different inflammatory stimuli, overexpress a proinflammatory signature of genes. Among these, Ch25h is a gene overexpressed in brain tissue from Alzheimer's disease as well as various mouse models of neuroinflammation. Ch25h encodes cholesterol 25-hydroxylase, an enzyme upregulated in activated microglia under conditions of neuroinflammation, that hydroxylates cholesterol to form 25-hydroxycholesterol (25HC). 25HC can be further metabolized to 7α,25-dihydroxycholesterol, which is a potent chemoattractant of leukocytes. We have previously shown that 25HC increases the production and secretion of …

Performance Of Ag‑Doped Cuo Nanoparticles For Photocatalytic Activity Applications: Synthesis, Characterization, And Antimicrobial Activity, Samar A. Salim, Ahmed Mosleh, Elbadawy A. Kamoun, Shahira H El-Moslamy, Heba Zahran, Samer Zyoud, Ibrahim Yahia

Nanotechnology Research Centre

The auto-combustion method synthesized CuO NPs and Ag/CuO NPs. The Ag/CuO NPs were analyzed using Fourier-transform infrared, X-ray difraction, scanning electron microscope, and Energy-dispersive X-ray spectroscopy instrumental analyses. The energy band gap, as determined by DRS properties, decreases from 3.82 to 3.50 eV for pure CuO and 10% Ag/CuO NPs, respectively. The photodegradation efciency of Rhodamine-B & Carmine by 10% Ag/CuO NPs was nearly 98.9 and 97.8%, respectively. Antimicrobial trials revealed that the antimicrobial efficacy of Ag/CuO NPs at several dosages (20, 40, 60, 80, 100, and 120 µg/mL) against human pathogens was initially assessed using the agar well-diffusion method, …

Vol. 26, No. 11 - Whole No. 114, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 10 - Whole No. 113, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 9 - Whole No. 112, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 8 - Whole No. 111, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 7 - Whole No. 110, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 6 - Whole No. 109, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 5 - Whole No. 108, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 26, No. 1 - Whole No. 104, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Primary Prevention And Motivational Interviewing: Patterns In Athletic Training, Mark C. West, Justin P. Young, Matthew J. Rivera, Kenneth E. Games

Internet Journal of Allied Health Sciences and Practice

Background: The BOC practice analysis defines the first domain as Risk Reduction, Wellness and Health Literacy including, “Promoting healthy lifestyle behaviors with effective education and communication.” There is limited evidence on primary prevention measures athletic trainers (ATs) use to address health-related behaviors. Motivational interviewing is an evidence-based patient-centered style of communication used to help patients modify detrimental health behaviors to improve health outcomes. The purpose of this study was to explore knowledge and practice patterns of primary prevention and motivational interviewing in athletic training. Methods: We used a cross-sectional, web-based survey (Qualtrics, Provo, UT). The survey contained demographic questions, …

Uroplectes Ebogo Sp. N. (Scorpiones: Buthidae) From Cameroon, František Kovařík, František Šťáhlavský, Valeriy Govorov

Euscorpius

A new species Uroplectes ebogo sp. n. is described from Cameroon, fully illustrated with color photos showing its morphology and habitus. Uroplectes ebogo sp. n. is the only species of the genus with a combination two characters: metasoma without carinae and metasoma V and telson without punctuation. In addition to morphology and hemispermatophore, we also present the information about the karyotype of Uroplectes ebogo sp. n. (2n=24).

Agricultural Producers' Perceptions Of Stressors: A Study On Controllability And Persistency, Mary Nelson Robertson, Devon Mills, Brice A. Fortinberry, Mary Marshall Waller, Hunter H. Thompson, Marina Denny, David Buys

Journal of Public Health in the Deep South

Farm stress negatively impacts agricultural producers’ (APs) physical and mental health. The average age of agricultural producers has increased in every USDA agricultural census since 1945, and the stressors may be either or both caused or exacerbated by increasing age. The Cooperative Extension Service is well-known for working with APs and is well-equipped to address these concerns for this aging population. To better understand farm-related stressors, this study examines APs’ and Extension agents’ perceptions of major stressors faced by APs. Focus groups were held to identify stressors and determine the controllability and persistency of those stressors. The mean age of …

Water Memory, Jessa C. Suganob

Kritika Kultura

No abstract provided.

A Phenomenological Study Of Islandness As A Global Sense Of Place: Focusing On The Animated Film Moana, Taehee Kim

Kritika Kultura

This article explores the question of whether islandness exists, and if so, how it can be defined. Using phenomenological methods, it examines a cultural text relevant to this question: the animated film Moana, which tells a story set on a small island. Following phenomenological procedures, any unexamined preconceptions about islandness are methodologically excluded through the suspension of judgment (epoché); islandness is defined as the “sense of place of the island” through a return to intersubjective intentionality (phenomenological reduction); the “essence” of this sense of place of the island is identified through imaginative variation (eidetic reduction). This discourse will shed light …

Youtube Digital Storytelling Of Korean Uninhabited Islands, Jooyoung Kim

Kritika Kultura

South Korea, with its extensive coastline and numerous islands, such as Jejudo, Ulleungdo, and Dokdo, is home to several uninhabited islands. These uninhabited islands embody dual roles as nostalgic symbols and territorial entities while also enduring marginalization and distortion stemming from their inhospitable conditions. Nonetheless, the emergence of recent trends in YouTube digital storytelling within South Korea has propelled uninhabited islands into the spotlight, as a result of which these islands have received considerable attention. By examining the creation and reception of YouTube narratives, we can gain valuable insights into the ever-evolving landscape of digital culture and its broader implications …