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Articles 30121 - 30150 of 30571
Full-Text Articles in Entire DC Network
Advancing The Understanding Of Clinical Sepsis Using Gene Expression–Driven Machine Learning To Improve Patient Outcomes, Asrar Rashid, Feras Al-Obeidat, Wael Hafez, Govind Benakatti, Rayaz A. Malik, Christos Koutentis, Javed Sharief, Joe Brierley, Nasir Quraishi, Zainab A. Malik, Arif Anwary, Hoda Alkhzaimi, Syed Ahmed Zaki, Praveen Khilnani, Raziya Kadwa, Rajesh Phatak, Maike Schumacher, M. Guftar Shaikh, Ahmed Al-Dubai, Amir Hussain
Advancing The Understanding Of Clinical Sepsis Using Gene Expression–Driven Machine Learning To Improve Patient Outcomes, Asrar Rashid, Feras Al-Obeidat, Wael Hafez, Govind Benakatti, Rayaz A. Malik, Christos Koutentis, Javed Sharief, Joe Brierley, Nasir Quraishi, Zainab A. Malik, Arif Anwary, Hoda Alkhzaimi, Syed Ahmed Zaki, Praveen Khilnani, Raziya Kadwa, Rajesh Phatak, Maike Schumacher, M. Guftar Shaikh, Ahmed Al-Dubai, Amir Hussain
All Works
Sepsis remains a major challenge that necessitates improved approaches to enhance patient outcomes. This study explored the potential of machine learning (ML) techniques to bridge the gap between clinical data and gene expression information to better predict and understand sepsis. We discuss the application of ML algorithms, including neural networks, deep learning, and ensemble methods, to address key evidence gaps and overcome the challenges in sepsis research. The lack of a clear definition of sepsis is highlighted as a major hurdle, but ML models offer a workaround by focusing on endpoint prediction. We emphasize the significance of gene transcript information …
Aquatic Connectivity: Challenges And Solutions In A Changing Climate, Paul A. Franklin, Tea Bašić, Phil I. Davison, Katie Dunkley, Jonathan Ellis, Mayuresh Gangal, Alexia M. González-Ferreras, Catherine Gutmann Roberts, Georgina Hunt, Domino Joyce, C. Antonia Klöcker, Rachel Mawer, Timo Rittweg, Velizara Stoilova, Lee Frank Gordon Gutowsky
Aquatic Connectivity: Challenges And Solutions In A Changing Climate, Paul A. Franklin, Tea Bašić, Phil I. Davison, Katie Dunkley, Jonathan Ellis, Mayuresh Gangal, Alexia M. González-Ferreras, Catherine Gutmann Roberts, Georgina Hunt, Domino Joyce, C. Antonia Klöcker, Rachel Mawer, Timo Rittweg, Velizara Stoilova, Lee Frank Gordon Gutowsky
School of Geography, Earth and Environmental Sciences
The challenge of managing aquatic connectivity in a changing climate is exacerbated in the presence of additional anthropogenic stressors, social factors, and economic drivers. Here we discuss these issues in the context of structural and functional connectivity for aquatic biodiversity, specifically fish, in both the freshwater and marine realms. We posit that adaptive management strategies that consider shifting baselines and the socio-ecological implications of climate change will be required to achieve management objectives. The role of renewable energy expansion, particularly hydropower, is critically examined for its impact on connectivity. We advocate for strategic spatial planning that incorporates nature-positive solutions, ensuring …
A Survey On Artificial Intelligence In Cybersecurity For Smart Agriculture: State-Of-The-Art, Cyber Threats, Artificial Intelligence Applications, And Ethical Concerns, Guma Ali, Maad M. Mijwil, Bosco Apparatus Buruga, Mostafa Abotaleb, Ioannis Adamopoulos
A Survey On Artificial Intelligence In Cybersecurity For Smart Agriculture: State-Of-The-Art, Cyber Threats, Artificial Intelligence Applications, And Ethical Concerns, Guma Ali, Maad M. Mijwil, Bosco Apparatus Buruga, Mostafa Abotaleb, Ioannis Adamopoulos
Mesopotamian Journal of Computer Science
Wireless sensor networks and Internet of Things devices are revolutionizing the smart agriculture industry by increasing production, sustainability, and profitability as connectivity becomes increasingly ubiquitous. However, the industry has become a popular target for cyberattacks. This survey investigates the role of artificial intelligence (AI) in improving cybersecurity in smart agriculture (SA). The relevant literature for the study was gathered from Nature, Wiley Online Library, MDPI, ScienceDirect, Frontiers, IEEE Xplore Digital Library, IGI Global, Springer, Taylor & Francis, and Google Scholar. Of the 320 publications that fit the search criteria, 180 research papers were ultimately chosen for this investigation. The review …
Enhancing Motion Detection In Video Surveillance Systems Using The Three-Frame Difference Algorithm, Suhaib Qassem Yahya Al-Hashemi, Majid Salal Naghmash, Ahmad Ghandour
Enhancing Motion Detection In Video Surveillance Systems Using The Three-Frame Difference Algorithm, Suhaib Qassem Yahya Al-Hashemi, Majid Salal Naghmash, Ahmad Ghandour
Mesopotamian Journal of Computer Science
This paper outlines a methodology for motion detection in video surveillance systems, leveraging advanced algorithms and TCP/IP networks for real-time data acquisition and analysis. The primary focus is on the implementation of the Three-Frame Difference Algorithm, which detects moving targets by analyzing the differences between three consecutive video frames. This method significantly reduces redundant data transmission and storage, addressing the challenges posed by limited wireless network capabilities. The surveillance model, designed in MATLAB using SIMULINK, integrates computer vision systems with embedded coders to facilitate effective communication and processing of video data. The results demonstrate the system's capability to detect motion …
2023 Nh Field Crop And Forage Loss Report, Sarah Allen
2023 Nh Field Crop And Forage Loss Report, Sarah Allen
UNH Cooperative Extension
No abstract provided.
2024 Belknap County 4-H Presents, Karen Deighan
2024 Belknap County 4-H Presents, Karen Deighan
UNH Cooperative Extension
No abstract provided.
North Haverhill Fair 4-H Exhibit Hall Information Packet - 2024, Extension
North Haverhill Fair 4-H Exhibit Hall Information Packet - 2024, Extension
UNH Cooperative Extension
No abstract provided.
North Haverhill Fair 4-H Schedule Of Events - 2024, Extension
North Haverhill Fair 4-H Schedule Of Events - 2024, Extension
UNH Cooperative Extension
No abstract provided.
4-H And Open Horse Show, Diane Dugray
Aquaculture In Zambia: The Current Status, Challenges, Opportunities And Adaptable Lessons Learnt From China, Lin Zhang, Sahya Maulu, Fenglei Hua, Majory K.H. Chama, Pao Xu
Aquaculture In Zambia: The Current Status, Challenges, Opportunities And Adaptable Lessons Learnt From China, Lin Zhang, Sahya Maulu, Fenglei Hua, Majory K.H. Chama, Pao Xu
School of Biological and Marine Sciences
As a land-locked country in Southern Africa, Zambia is rich in natural resources suitable for fish production. However, aquaculture is still in its infancy with enormous potential as most of Zambia’s fish now comes from capture fisheries. The aim of this study was to review the recent progress, status, challenges, and opportunities in Zambia’s aquaculture industry while drawing some lessons from China’s aquaculture experience, focusing on policy instruments, external support, quality seeds, and the investment environment for possible adaptation. To achieve this, we reviewed the existing literature about aquaculture in Zambia. This paper starts by reviewing the overall fishery sector’s …
Sieving Silence: The Communal Question And The Archive Of Indian Constitutional History, Kanika Gauba
Sieving Silence: The Communal Question And The Archive Of Indian Constitutional History, Kanika Gauba
National Law School Journal
This paper shows how the archive of Indian constitutional history limits access to constitutional disagreement. It attempts an alternative framing of the issue of political safeguards for religious minorities (‘the communal question’) as a triangle of disagreement among the Sikhs, the Anglo‑Indians, and Sardar Vallabhbhai Jhaverbhai Patel. However, the task is complicated by the silence in the official archives on all three actors. If, as critical historians argue, silence is the very condition of the archive and the writing of history, this paper argues that the historian must ‘sieve’ the inevitably silent archives of Indian constitutional history for perturbations, follow …
Mangrove Sediments-Associated Bacterium (Bacillus Sp. Sw7) With Multiple Plant Growth-Promoting Traits Promotes The Growth Of Tomato (Solanum Lycopersicum), Mahideen Afridi, Balamurugan Sadaiappan, Amna Saood Nassar, Henda Mahmoudi, Munawwar Ali Khan, Sunil Mundra
Mangrove Sediments-Associated Bacterium (Bacillus Sp. Sw7) With Multiple Plant Growth-Promoting Traits Promotes The Growth Of Tomato (Solanum Lycopersicum), Mahideen Afridi, Balamurugan Sadaiappan, Amna Saood Nassar, Henda Mahmoudi, Munawwar Ali Khan, Sunil Mundra
All Works
Global food production intensification presents a major hurdle to ensuring food security amidst a growing world population. Widespread use of chemical fertilizers in recent decades has risked soil fertility, compounded by the challenges posed by climate change, particularly in arid regions. To address these issues, adopting plant growth-promoting (PGP) bacteria stands out as a promising solution, offering multifaceted benefits to arid agroecosystems. We isolated a bacterial strain, SW7, from mangrove sediment, characterised the entire genome followed by phylogenetic analyses, and evaluated its in-vitro PGP activity. Subsequently, we examined its impact on tomato seed germination and plant growth. The strain SW7 …
Diagnostic Performance Of Ai-Based Models Versus Physicians Among Patients With Hepatocellular Carcinoma: A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Wael Hafez, Muneir Gador, Nesma Ahmed, Marwa Muhammed Abdeljawad, Antesh Yadav, Asrar Rashed
Diagnostic Performance Of Ai-Based Models Versus Physicians Among Patients With Hepatocellular Carcinoma: A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Wael Hafez, Muneir Gador, Nesma Ahmed, Marwa Muhammed Abdeljawad, Antesh Yadav, Asrar Rashed
All Works
Background: Hepatocellular carcinoma (HCC) is a common primary liver cancer that requires early diagnosis due to its poor prognosis. Recent advances in artificial intelligence (AI) have facilitated hepatocellular carcinoma detection using multiple AI models; however, their performance is still uncertain. Aim: This meta-analysis aimed to compare the diagnostic performance of different AI models with that of clinicians in the detection of hepatocellular carcinoma. Methods: We searched the PubMed, Scopus, Cochrane Library, and Web of Science databases for eligible studies. The R package was used to synthesize the results. The outcomes of various studies were aggregated using fixed-effect and random-effects models. …
Cheating And The Effect Of Promises In Indian And German Children, Patricia Kanngiesser, Jahnavi Sunderarajan, Jan K. Woike
Cheating And The Effect Of Promises In Indian And German Children, Patricia Kanngiesser, Jahnavi Sunderarajan, Jan K. Woike
School of Psychology
Cheating is harmful to others and society at large. Promises have been shown to increase honesty in children, but their effectiveness has not been compared between different cultural contexts. In a study (2019) with 7- to 12-year-olds (N = 406, 48% female, middle-class), voluntary promises reduced cheating in Indian, but not in German children. Children in both contexts cheated, but cheating rates were lower in Germany than in India. In both contexts, cheating decreased with age in the (no-promise) control condition and was unaffected by age in the promise condition. These findings suggest that there may exist a threshold beyond …
Mouralherwaqh: Coastal Wetland Road Crossing Da’Luk, Filip Amborski
Mouralherwaqh: Coastal Wetland Road Crossing Da’Luk, Filip Amborski
Cal Poly Humboldt theses and projects
The integration of Indigenous and Western science plays an essential role in Tribally led collaborations for land management. This process of woven sciences is rooted in reciprocal relations and partnerships guided by Tribal Nations. Our cohort was invited by Wiyot Tribal Representatives to investigate a culvert located within the wetlands of Mouralherwaqh— a parcel of land reacquired by the Wiyot Tribe in 2022. This document seeks to share our experience and analysis as part of the Wiyot Tribe’s broader journey in navigating ecocultural restoration projects within Mouralherwaqh. The four community interests we investigated for the wetland crossing included a resized …
Water And Hornets And Bears – Oh My: When Nature Disregards Human-Made Boundaries, Bonnie M. Pace
Water And Hornets And Bears – Oh My: When Nature Disregards Human-Made Boundaries, Bonnie M. Pace
Graduate Student Theses, Dissertations, & Professional Papers
No abstract provided.
Application And Development Of Conjugation Technology To Enhance Therapeutic Index Of Tlr7/8 Agonists For Vaccines, Noah Robert Powers
Application And Development Of Conjugation Technology To Enhance Therapeutic Index Of Tlr7/8 Agonists For Vaccines, Noah Robert Powers
Graduate Student Theses, Dissertations, & Professional Papers
Toll-like receptor 7/8 (TLR7/8) agonists represent a promising vaccine adjuvant target as they directly activate innate Th1-type proinflammatory responses inducing both humoral and cell mediated immunity. However, co-delivery of the small molecule agonists with subunit antigens to the target dendritic cells (DCs) is difficult due to their highly divergent physical and chemical properties resulting in rapid dissociation of the two components. Conjugation of adjuvant to antigen can co-deliver to DCs, mimicking the natural infection these cells have evolved to detect though successful formulation can be difficult due to poor aqueously soluble adjuvants and antigen instability. We have previously shown and …
Integrating Individual And Species Traits To Better Identify Risks To Persistence And Survival In Amphibian Populations, Ross Kenneth Hinderer
Integrating Individual And Species Traits To Better Identify Risks To Persistence And Survival In Amphibian Populations, Ross Kenneth Hinderer
Graduate Student Theses, Dissertations, & Professional Papers
Amphibians have experienced major declines and are highly vulnerable to the impacts of climate change. Yet we still lack sufficient information to understand where amphibians are most vulnerable to changes in climate and how effects might manifest. In this dissertation, I worked to understand risks due to climate change and investigate effective indicators of survival in amphibians. To predict which species might be most affected by increasingly dry conditions, in Chapter 1, I extended the climate change vulnerability assessment framework to rank amphibian vulnerability based on projected climate change and species life history traits. Traits including clutch size, daily activity …
Tracing Socio-Ecological Resilience In The Milpa, The Monte, And The Kitchen: Milpero And Campesino Perspectives From Tiholop, Yucatan And La Union Libertad, Oaxaca, Mexico, Marisela Chavez
Graduate Student Theses, Dissertations, & Professional Papers
Agrobiodiversity, the diversity of crops that been co-produced through humanenvironment interactions over millennia, constitutes an important part of humanity’s cultural heritage. Agrobiodiversity is as much about the local ecosystem and biotic resources, such as soil, water, pollinators, and microbes, as it is about human processes like sociocultural and linguistic practices, including farming methods, knowledge, skills, and natural resource management. At the center of these dynamics are the smallholder farmers who engage in a range of stewardship practices that contribute to the diversification and evolution of the native crops that in turn support their food security. This research focuses on understanding …
Using Ethnobotanicals For Language Preservation And Cultural Connections, Riza James Mcclurkin
Using Ethnobotanicals For Language Preservation And Cultural Connections, Riza James Mcclurkin
Graduate Student Theses, Dissertations, & Professional Papers
The creation and implementation of interpretive ethnobotanical trails can be used to help preserve and teach about the use of native, and in some instances, non-native plants that were brought into use, both historically and in present day by Indigenous peoples. As examples, I will use my work assisting on the Reserve Street Trail in Missoula, Montana and the Pioneer Park Campground Interpretive Trail on the Colville National Forest in Washington. The Reserve Street Trail is still in its beginning phases but has the goal to cultivate plants identified as being culturally significant to Indigenous peoples and to create trail …
Beyond The Participation Gap: Exploring How Affinity Groups Make Outdoor Recreation More Accessible And Inclusive For Underserved Communities, Jaclyn Fox Rushing
Beyond The Participation Gap: Exploring How Affinity Groups Make Outdoor Recreation More Accessible And Inclusive For Underserved Communities, Jaclyn Fox Rushing
Graduate Student Theses, Dissertations, & Professional Papers
Outdoor recreation is associated with numerous health and wellness benefits for participants. Yet, there has been a long-term underrepresentation of underserved communities in outdoor recreation (i.e., people of color, LGBTQ+, and people with disabilities). This phenomenon has spurred substantial research since the 1970s, which has characterized the problem well and identified many of the underlying reasons. In recent years, there have been widespread efforts to increase relevance, diversity, equity, and inclusion (RDEI) in outdoor recreation and public land management, however participation among underserved communities remain relatively unchanged despite an increasingly diverse American public. This study seeks to move beyond describing …
Exploring The Potential Of A Ephedra Alata Leaf Extract: Phytochemical Analysis, Antioxidant Activity, Antibacterial Properties, And Green Synthesis Of Zno Nanoparticles For Photocatalytic Degradation Of Methylene Blue, Abdelmalek Zaater, Mohammed Oualid Serhoud, Ilham Ben Amor, Soumeia Zeghoud, Amira Hemmami, Abdelkrim Rebiai, Yacine Bouras, Ammar Touhami Laiche, Ali Alsalme, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Exploring The Potential Of A Ephedra Alata Leaf Extract: Phytochemical Analysis, Antioxidant Activity, Antibacterial Properties, And Green Synthesis Of Zno Nanoparticles For Photocatalytic Degradation Of Methylene Blue, Abdelmalek Zaater, Mohammed Oualid Serhoud, Ilham Ben Amor, Soumeia Zeghoud, Amira Hemmami, Abdelkrim Rebiai, Yacine Bouras, Ammar Touhami Laiche, Ali Alsalme, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Research Outputs: 2025-Present
Ephedra alata leaf extracts have therapeutic properties and contain various natural compounds known as phytochemicals. This study assessed the phytochemical content and antioxidant effects of a Ephedra alata leaf extract, as well as zinc oxide (ZnO) nanoparticle production. The extract contained phenolic acids, including vanillic acid, chlorogenic acid, gallic acid, p-coumaric acid, vanillin and rutin. Its total phenolic content and total flavonoid content were 48.7 ± 0.9 mg.g-1 and 1.7 ± 0.4 mg.g-1, respectively. The extract displayed a DPPH inhibition rate of 70.5%, total antioxidant activity of 49.5 ± 3.4 mg.g-1, and significant antimicrobial activity …
Development Of Polyvinyl Alcohol Nanofiber Scaffolds Loaded With Flaxseed Extract For Bone Regeneration: Phytochemicals, Cell Proliferation, Adhesion, And Osteogenic Gene Expression, Ahmed G. Abdelaziz, Hassan Nageh, Mohga S. Abdalla, Sara M. Abdo, Asmaa A. Amer, Samah A. Loutfy, Nasra F. Abdel Fattah, Ali Alsalme, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Development Of Polyvinyl Alcohol Nanofiber Scaffolds Loaded With Flaxseed Extract For Bone Regeneration: Phytochemicals, Cell Proliferation, Adhesion, And Osteogenic Gene Expression, Ahmed G. Abdelaziz, Hassan Nageh, Mohga S. Abdalla, Sara M. Abdo, Asmaa A. Amer, Samah A. Loutfy, Nasra F. Abdel Fattah, Ali Alsalme, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Research Outputs: 2025-Present
Introduction: Bone tissue engineering seeks innovative materials that support cell growth and regeneration. Electrospun nanofibers, with their high surface area and tunable properties, serve as promising scaffolds. This study explores the incorporation of flaxseed extract, rich in polyphenolic compounds, into polyvinyl alcohol (PVA) nanofibers to improve their application in bone tissue engineering. Methods: High-performance liquid chromatography (HPLC) identified ten key compounds in flaxseed extract, including polyphenolic acids and flavonoids. PVA nanofibers were fabricated with 30 wt.% flaxseed extract (P70/E30) via electrospinning. We optimized characteristics like diameter, hydrophilicity, swelling behavior, and hydrolytic degradation. MG-63 osteoblast cultures were used to assess scaffold …
Antimutagenic And Anticoagulant Therapeutic Effects Of Ag/Ag2O Nanoparticles From Olea Europaea Leaf Extract: Mitigating Metribuzin-Induced Hepato-And Nephrotoxicity, Manel Azzi, Ibtissam Laib, Abderrhmane Bouafia, Ifriqya Medila, Ali Tliba, Salah Eddine Laouini, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Antimutagenic And Anticoagulant Therapeutic Effects Of Ag/Ag2O Nanoparticles From Olea Europaea Leaf Extract: Mitigating Metribuzin-Induced Hepato-And Nephrotoxicity, Manel Azzi, Ibtissam Laib, Abderrhmane Bouafia, Ifriqya Medila, Ali Tliba, Salah Eddine Laouini, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Research Outputs: 2025-Present
Background: Silver nanoparticles (Ag/Ag₂O NPs) have garnered attention for their potent antioxidant, antimicrobial, and anti-inflammatory properties, showing promise for therapeutic applications, particularly in mitigating chemical-induced toxicity. Objective: This study aimed to synthesize Ag/Ag₂O NPs using Olea europaea (olive) leaf extract as a green, eco-friendly reducing agent and evaluate their protective effects against metribuzin-induced toxicity in Wistar rats, focusing on oxidative stress, hematological parameters, and lipid profiles, with specific dose optimization. Methodology: Ag/Ag₂O NPs were synthesized using Olea europaea leaf extract, and their properties were confirmed via XRD, FTIR, SEM, EDS, and UV-visible spectroscopy. Wistar rats exposed to metribuzin (110 mg/kg/day) …
Fabrication Of Cellulose Nanocrystals/Carboxymethyl Cellulose/Zeolite Membranes For Methylene Blue Dye Removal: Understanding Factors, Adsorption Kinetics, And Thermodynamic Isotherms, Mostafa Ahmed Ibrahim, Ahmed Salama, Fouad Zahran, Mohamed Saleh Abdelfattah, Ali Alsalme, Mikhael Bechelany, Ahmed Barhoum
Fabrication Of Cellulose Nanocrystals/Carboxymethyl Cellulose/Zeolite Membranes For Methylene Blue Dye Removal: Understanding Factors, Adsorption Kinetics, And Thermodynamic Isotherms, Mostafa Ahmed Ibrahim, Ahmed Salama, Fouad Zahran, Mohamed Saleh Abdelfattah, Ali Alsalme, Mikhael Bechelany, Ahmed Barhoum
Research Outputs: 2025-Present
This study introduces environmentally-friendly nanocellulose-based membranes for AZO dye (methylene blue, MB) removal from wastewater. These membranes, made of cellulose nanocrystals (CNCs), carboxymethyl cellulose (CMC), zeolite, and citric acid, aim to offer eco-friendly water treatment solutions. CNCs, obtained from sugarcane bagasse, act as the foundational material for the membranes. The study aims to investigate both the composition of the membranes (CMC/CNC/zeolite/citric acid) and the critical adsorption factors (initial MB concentration, contact time, temperature, and pH) that impact the removal of the dye. After systematic experimentation, the optimal membrane composition is identified as 60% CNC, 15% CMC, 20% zeolites, and 5% …
Tarantula Toxin Transcripts And Toxin Structure Prediction By Alphafold, Christine Vega, Rebekkah Sepulveda, Ying Jia
Tarantula Toxin Transcripts And Toxin Structure Prediction By Alphafold, Christine Vega, Rebekkah Sepulveda, Ying Jia
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Tarantula venom predominantly comprises peptides and small proteins (venom toxins). To explore this further, we generated a combined gland cDNA library from five different tarantula species. Subsequently we randomly sequenced 752 clones, which led to the identification of sixteen distinct toxin groups, including one novel group. Each group consists of a minimum of three identical sequences. A comprehensive analysis of these toxin groups was carried out, and we simulated the 3D structures of certain predicted toxins. These transcripts can be used to the production of venom toxins through recombinant techniques, offering promising applications in various biomedical applications.
The Development And Validation Of A Novel Patient-Derived 3d Meningioma Cell Culture Model, Laurien Lisette Van De Weijer
The Development And Validation Of A Novel Patient-Derived 3d Meningioma Cell Culture Model, Laurien Lisette Van De Weijer
Peninsula Medical School Theses
Meningiomas are the most frequent intracranial brain tumours. Current treatment options of surgery and radiotherapy are sometimes insufficient and effective systemic therapies remain unestablished. The development of accurate in vitro systems to model the complexity of meningioma pathology is essential for predicting drug response and developing novel therapeutics. Therefore, in this study, I established an easy-to-use in vitro patient-derived meningioma spheroid model that maintained the morphological and molecular features of the parental tumours, including tissue histology, the tumour microenvironment, and the mutational profile. Comprehensive characterisation of the global transcriptomes of the novel patient-derived spheroids with traditional meningioma monolayer cultures and …
Pre-Clinical Targets For Ischemic Brain Injury, Daniel Morgan
Pre-Clinical Targets For Ischemic Brain Injury, Daniel Morgan
Peninsula Medical School Theses
Stroke is the second most common cause of disability worldwide, and 87% of strokes result from a blockage in the cerebral blood flow which results in ischemia. Injury to the myelinated axons located in white matter is observed in ischemic injuries but is generally underappreciated. Research has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to oligodendrocytes, resulting in demyelination. Glutamate receptor antagonists have been trialled in stroke patients but fall short due to adverse side effects from high dose preparations. Stroke is largely a disease of ageing, and may occur in the presence of …
Hermit Crabs As Model Species For Investigating The Behavioural Responses To Pollution, Mark Briffa, Gareth Arnott, Jörg D. Hardege
Hermit Crabs As Model Species For Investigating The Behavioural Responses To Pollution, Mark Briffa, Gareth Arnott, Jörg D. Hardege
School of Biological and Marine Sciences
Human impacts on the environment affect organisms at all levels of biological organisation and ultimately can change their phenotype. Over time, phenotypic change may arise due to selection but individual phenotypes are also subject to change via genotype × environment interactions. In animals, behaviour is the most flexible aspect of phenotype, and hence the most liable to change across environmental gradients including exposure to pollution. Here we review current knowledge on the impacts of pollution, broadly defined to include the release of substances, energy, and the effects of carbon emissions, on the behaviour of a highly studied group, the globally …
Green Synthesis And Characterization Of Senps Using Pediastrum Boryanum Extract And Evaluation Of Their Biological Activities, Ahmed H Al-Wakeel, Samia Elbahnaswy, Amany Abd El‐Moaty, Ayman M. El-Ghamry, Ayman Y. El-Khateeb, Engy Risha, Eman Zahran
Green Synthesis And Characterization Of Senps Using Pediastrum Boryanum Extract And Evaluation Of Their Biological Activities, Ahmed H Al-Wakeel, Samia Elbahnaswy, Amany Abd El‐Moaty, Ayman M. El-Ghamry, Ayman Y. El-Khateeb, Engy Risha, Eman Zahran
Mansoura Veterinary Medical Journal
Background Selenium nanoparticles (SeNPs) were synthesized using a green method with Pediastrum boryanum extract as the reducing and capping agent. Objectives The algal extract and green synthesized SeNPs were characterized for their morphological characters and biological efficacy. Methods Characterization was conducted using UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and zeta potential analysis. Results TEM revealed spherical and tetragonal SeNPs with sizes ranging from 72.16-89.45 nm. FTIR spectroscopy confirmed the presence of functional groups from the algal extract on the SeNPs surfaces, indicating their role as capping agents. Phytochemical analysis showed that the extract had higher …