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2024

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Optimal Dual-Time-Point Dynamic 68ga-Psma-11 Pet/Ct Protocols For Parametric Imaging Generation In Prostate Cancer Patients, Paphawarin Burasothikul Jan 2024

Optimal Dual-Time-Point Dynamic 68ga-Psma-11 Pet/Ct Protocols For Parametric Imaging Generation In Prostate Cancer Patients, Paphawarin Burasothikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Globally, prostate cancer is the second most common cancer for men. Prostate cancer patients presenting metastasis exhibit a poor prognosis, consequently leading to diminished survival rates. Thus, 68Ga-PSMA-11 PET/CT examination plays a critical role in prostate cancer diagnosis. Parametric imaging techniques offer the potential to improve the accuracy of quantification analysis in PET/CT diagnosis, but their effectiveness is constrained by lengthy acquisition protocols. This study developed optimal dual-time-point (DTP) parametric imaging using shortened dynamic 68Ga-PSMA-11 PET/CT scans in prostate cancer patients and investigated the feasibility of parametric images in terms of image quality by comparing them with a routine standardized …

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การสร้างแอนิเมชัน 3 มิติ ของใบหน้าขณะพูดภาษาไทยสําหรับใช้ในการพัฒนาเกม, ภัทรานิษฐ์ มุสิกะประยูร Jan 2024

การสร้างแอนิเมชัน 3 มิติ ของใบหน้าขณะพูดภาษาไทยสําหรับใช้ในการพัฒนาเกม, ภัทรานิษฐ์ มุสิกะประยูร

Chulalongkorn University Theses and Dissertations (Chula ETD)

โครงงานมหาบัณฑิตนี้จึงเสนอวิธีการสร้างแอนิเมชัน 3 มิติ ของใบหน้าขณะพูดภาษาไทยสำหรับใช้ในการพัฒนาเกม ในการสร้างแบบจำลองเพื่อทำนายการเคลื่อนไหวของใบหน้าขณะพูดภาษาไทย ได้ใช้ชุดข้อมูลออดิโอวิชวล TSynC-3miti: Audiovisual Speech Synthesis Database from Found Data ร่วมกับแนวคิดจาก งานวิจัย A Decision Tree Framework for Spatiotemporal Sequence Prediction ที่ได้เสนอวิธีการสำหรับการทำนายลำดับข้อมูลที่มีจำนวนมิติสูงและต่อเนื่อง โดยใช้เทคนิคการแบ่งย่อยด้วยหน้าต่างเลื่อนร่วมกับวิธีการรวมกลุ่มของต้นไม้ตัดสินใจ ซึ่งสามารถนำมาประยุกต์ใช้ในการสร้างแอนิเมชันสำหรับการพูดได้ ในการทำนายการเคลื่อนไหวของใบหน้าขณะพูดภาษาไทยในโครงงานมหาบัณฑิตนี้ จะใช้ข้อมูลนำเข้าเป็นลำดับของสัญลักษณ์โฟเนติก จากจึงต้องมีการเตรียมชุดข้อมูลใหม่จากชุดข้อมูลออิดิโอวิชวล TSynC-3miti จากนั้นนำชุดข้อมูลไปฝึกสอนโมเดล และพัฒนาเครื่องมือที่ใช้ในการสร้างแอนิเมชัน โดยเป็นรูปแบบของส่วนเสริมสำหรับใช้ในเกมเอนจิน Unreal Engine โดยรับอินพุตเป็นข้อความภาษาไทย และจะได้ค่าการเคลื่อนไหวใบหน้ามาอ้างอิงบนใบหน้าของตัวละครในแต่ละช่วงเวลา ผลลัพธ์ของการทำงานของส่วนเสริมนี้จะได้เป็นแอนิเมชัน 3 มิติของโมเดลตัวละคร MetaHuman ที่สามารถพูดภาษาไทยได้อย่างสมจริง โดยผลการทดสอบพบว่าแอนิเมชันมีความสมจริงจากมุมมองทั้งหน้าตรงและหน้าเอียง โดยมุมมองหน้าเอียงดูสมจริงมากกว่า และการออกเสียงแต่ละโฟเนติกมีความสมจริงเช่นกัน

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The Association Of Mirnas As Biomarkers For Severe Liver Dysfunction In Severe Dengue Infection, Napat Pas-Arj Jan 2024

The Association Of Mirnas As Biomarkers For Severe Liver Dysfunction In Severe Dengue Infection, Napat Pas-Arj

Chulalongkorn University Theses and Dissertations (Chula ETD)

Identification early biomarkers for severe liver dysfunction in severe dengue patients is essential. Currently, there is no any data on circulating miRNAs to predict this important complication, Therefore, this study aimed to explore the role of circulating miRNAs in severe liver dysfunction in dengue infection. On the initial day of admission, serum samples were gathered from patients with dengue infection. These patients were monitored for 14 days post-admission to ascertain their final diagnosis. Following the WHO 2009 criteria, participants were categorized into severe liver dysfunction and non-severe liver dysfunction group. To conduct a transcriptomic analysis of circulating miRNAs used the …

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Gene Expression By Nanostring Rna Profiling Of Monocytic Myeloid-Derived Suppressor Cells In Knee Osteoarthritis, Varote Shotelersuk Jan 2024

Gene Expression By Nanostring Rna Profiling Of Monocytic Myeloid-Derived Suppressor Cells In Knee Osteoarthritis, Varote Shotelersuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoarthritis (OA) is a widespread degenerative joint disease marked by cartilage destruction. This study investigates the role of monocytic myeloid-derived suppressor cells (M-MDSCs) in OA, focusing on their gene expression profiles and their relationship with body mass index (BMI) in knee OA patients. Previous research has shown a positive correlation between M-MDSCs and BMI in OA. We explored the role of M-MDSCs derived from the infrapatellar fat pad (IPFP) in OA patients.Using NanoString technology, we examined the transcriptional profile of M-MDSCs from the IPFP of knee OA patients undergoing total knee replacement surgery, categorized into different BMI groups. Flow cytometry …

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การศึกษาความเป็นไปได้เชิงพาณิชย์และการพัฒนาผลิตภัณฑ์ “เครื่องดื่มที่ใช้ข้าวกล้องงอกและดอกไม้ของสายพันธุ์ท้องถิ่นเชียงรายเพื่อเสริมสร้างความจำและภาวะอารมณ์ที่มีความสุข”, อัญมณี กาวิชัย Jan 2024

การศึกษาความเป็นไปได้เชิงพาณิชย์และการพัฒนาผลิตภัณฑ์ “เครื่องดื่มที่ใช้ข้าวกล้องงอกและดอกไม้ของสายพันธุ์ท้องถิ่นเชียงรายเพื่อเสริมสร้างความจำและภาวะอารมณ์ที่มีความสุข”, อัญมณี กาวิชัย

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้เป็นการศึกษาการพัฒนาเครื่องดื่มน้ำข้าวกล้องงอกพันธุ์หอมแม่จันและดอกพุดซ้อนเพื่อลดความเครียดเป็นหลักและเพิ่มความจำในกลุ่มคนอายุน้อย โดยพัฒนาเครื่องดื่มน้ำข้าวกล้องงอกที่เพิ่มสารสกัดกลิ่นจากดอกพุดซ้อนที่ปลูกแบบอินทรีย์ ซึ่งนิยมปลูกในเชียงรายในวัฒนธรรมล้านนา นำมาผ่านกระบวนการ High Pressure Processing (HPP) ผลการวิเคราะห์สารพบว่าสามารถคงสารกาบาไว้ได้ดีอย่างมีประสิทธิภาพ ซึ่งสารกาบาช่วยในการทำงานของระบบประสาทและสมอง ช่วยลดความเครียด และสารในดอกพุดซ้อนมีสารหอมระเหยที่ช่วยให้ผ่อนคลายอารมณ์ ลดความวิตกกังวล สารที่มีประโยชน์และกลิ่นจึงเป็นสองกลไกที่เสริมกันในเครื่องดื่มต้นแบบนี้ ผลการสำรวจการตลาดด้านความต้องการผู้บริโภคและการยอมรับผลิตภัณฑ์ด้วยแบบสอบถามกลุ่มเป้าหมายทั้งหมด 312 ราย พบว่าร้อยละ 69.23 มีแนวโน้มซื้อผลิตภัณฑ์ และยินดีจ่ายในราคาสูงกว่าเครื่องดื่มธัญพืชทั่วไปไม่ต่ำกว่า 20% ส่วนการศึกษาความเป็นไปได้ในเชิงพาณิชย์มีการประมาณเงินลงทุน 1 ล้านบาท อัตราผลตอบแทนภายใน 239% มูลค่าปัจจุบันสุทธิ 3,637,220 บาท และระยะเวลาคืนทุนภายใน 1 ปี 6 เดือน

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Genomic Analysis And Antimicrobial Resistance Of Vibrio Parahaemolyticus Isolated From Seawater At Bang Pu Recreational Center, Samut Prakan Province, Thailand, Chinnawat Assana Jan 2024

Genomic Analysis And Antimicrobial Resistance Of Vibrio Parahaemolyticus Isolated From Seawater At Bang Pu Recreational Center, Samut Prakan Province, Thailand, Chinnawat Assana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vibrio parahaemolyticus is a foodborne bacterium that is widely distributed in worldwide marine environments including seawater, marine animals, and soils. This study aimed to identify genetic and antimicrobial resistance (AMR) of V. parahaemolyticus (n=46) isolated from seawater at Bang Pu recreational center, Samut Prakan province, Thailand. Genetic analysis from multi-locus sequence typing (MLST) classified the seawater isolates into 42 sequence types (STs) in total, with 29 being novel STs and 13 STs matched with previously reported strains in worldwide including clinical strains (ST356, ST303, STST320, and ST1919) and environmental strains (ST222, ST1083, ST1089, ST969, ST2965, ST2249 and ST233). A phylogenetic …

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Virtual Reality Of Labless Welding For Next Industrial Training, Suphakit Anonglekha Jan 2024

Virtual Reality Of Labless Welding For Next Industrial Training, Suphakit Anonglekha

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research introduces an innovative Virtual Reality (VR) application designed to educate users on Welding operations. Its main goals include creating a realistic and immersive learning environment that is also safe. The development process involved the integration of multiple technologies, leveraging the Unity engine and 3D sculpting, all based on extensive research. With all of the type of weld works found in the welding laboratory represented, except the workpiece and electrode material, the VR application accuracy rating is calculated to 94%. The study's significance lies in its contribution to virtual education, especially in fields that require hands-on experience. The VR …

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ภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย, รวินท์นิภา ทองสาริ Jan 2024

ภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย, รวินท์นิภา ทองสาริ

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้เป็นงานวิจัยเชิงคุณภาพ มีวัตถุประสงค์ 1) เพื่อศึกษาภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย 2) เพื่อศึกษาปัจจัยที่มีผลต่อภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย 3) เพื่อสร้างข้อเสนอแนะในการส่งเสริมภาพสะท้อนเชิงบวกของประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย โดยใช้วิธีศึกษาการวิเคราะห์ภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย โดยการศึกษาจากซีรีส์ที่ออกอากาศทางโทรทัศน์เกาหลีใต้ในช่วงปี พ.ศ. 2547-2566 ระยะเวลา 19 ปี เป็นเรื่องที่ออกอากาศทางช่องโทรทัศน์ของสถานีเกาหลีใต้ 5 สถานี ได้แก่ KBS, SBS, MBC, JTBC และ TVN โดยศึกษาจากซีรีส์ที่มีฉากในประเทศไทยและเดินทางเข้ามาถ่ายทำในประเทศไทยจำนวน 11 เรื่อง ร่วมกับการการสัมภาษณ์เชิงลึก ผู้ที่มีส่วนเกี่ยวข้องในการเข้ามาถ่ายทำซีรีส์เกาหลีในประเทศไทยและนักวิชาการเกาหลีศึกษา จากการศึกษาการวิเคราะห์ภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในประเทศไทย แบ่งออกเป็น 3 ประเภท ได้แก่ ภาพสะท้อนประเทศไทยเชิงบวก แบ่งออกเป็น 5 ด้าน ได้แก่ ด้านการท่องเที่ยว ด้านอาหาร ด้านวัฒนธรรม ด้านความสัมพันธ์ระหว่างประเทศ ภาพสะท้อนประเทศไทยเชิงลบ แบ่งออกเป็น 4 ด้าน ได้แก่ ด้านคมนาคม ด้านสังคม ด้านความปลอดภัย ภาพสะท้อนประเทศไทยเชิงผสม แบ่งออกเป็น 2 ด้าน ได้แก่ ด้านภูมิอากาศ ด้านศาสนา ปัจจัยที่มีผลต่อภาพสะท้อนประเทศไทยในซีรีส์เกาหลีที่ถ่ายทำในไทย ได้แก่ ความสัมพันธ์ไทย-เกาหลีใต้ที่ดี การสนับสนุนจากรัฐบาลไทย ความเหมาะสมของบทและเนื้อเรื่อง นโยบายและเป้าหมายของเกาหลีใต้ อุตสาหกรรมภาพยนตร์ไทยที่มีทีมงานเชี่ยวชาญ และสถานที่ถ่ายทำที่หลากหลาย ข้อเสนอแนะเชิงบวกในการส่งเสริมภาพสะท้อนประเทศไทย ได้แก่ ส่งเสริมความร่วมมือทางวัฒนธรรม นำเสนอภาพสะท้อนที่ตรงกับความเป็นจริง เน้นเอกลักษณ์และความหลากหลายทางวัฒนธรรม สนับสนุนนโยบายและสิทธิประโยชน์ทางการเงิน โปรโมตจุดเด่นของไทยตลอดปี ส่งเสริมวัฒนธรรมไทยผ่านสื่อ ประสานงานกับชุมชนในพื้นที่ถ่ายทำ โปรโมตในเทศกาลภาพยนตร์นานาชาติ และใช้กลยุทธ์ Product Placement

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Biomarkers Of Comorbid Major Depression And Metabolic Syndrome: A Case-Control Study, Ketsupar Jirakran Jan 2024

Biomarkers Of Comorbid Major Depression And Metabolic Syndrome: A Case-Control Study, Ketsupar Jirakran

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mood disorders, including major depressive disorder (MDD), are among the leading causes of disability worldwide. Major depressive disorder (MDD) and bipolar disorder (BD) often coexist with metabolic syndrome. Increased atherogenicity and a higher risk of cardiovascular diseases are associated with both conditions. This study aimed to determine whether (a) ACEs are significantly associated with the 5 BFI personality dimensions in patients with MDD; (b) increased neuroticism or lowered levels of the other personality dimensions are associated with the phenome of MDD including suicidal behaviors; and (c) the effects of ACEs on the phenome of MDD are mediated via increased neuroticism …

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Sugar Composition Of Thai Desserts And Gut Microbiome Profiles In Healthy Volunteers: A Randomized Controlled Trial, Sayamon Senaprom Jan 2024

Sugar Composition Of Thai Desserts And Gut Microbiome Profiles In Healthy Volunteers: A Randomized Controlled Trial, Sayamon Senaprom

Chulalongkorn University Theses and Dissertations (Chula ETD)

The glycemic index (GI) measures the blood glucose-raising potential of carbohydrate-rich foods and is associated with obesity and insulin resistance. In addition, an imbalanced gut microbiota has been linked to elevated postprandial blood glucose levels. However, the relationship between consuming Thai desserts predominantly composed of carbohydrates and gut microbiome profiles remains unclear. This study aimed to evaluate the effects of consuming various Thai desserts with different GI values on the gut microbiomes of healthy volunteers. This open-label, parallel randomized clinical trial involved 30 healthy individuals aged 18 to 45 years. Participants were randomly assigned to one of three groups: Phetchaburi’s …

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Influence Of Out-Of-Home Advertising Value On Consumer Attitude And Purchase Intention Of Samsung Smartphones, Napat Kusolrerkdee Jan 2024

Influence Of Out-Of-Home Advertising Value On Consumer Attitude And Purchase Intention Of Samsung Smartphones, Napat Kusolrerkdee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research investigates the influence of out-of-home (OOH) advertising value on consumer attitudes and purchase intention towards Samsung smartphones. Data were collected via an online survey from 304 male and female respondents, aged 25 to 60 years, residing in Bangkok, who had encountered at least one of Samsung's OOH advertisements, including outdoor, transit, and in-store advertisements, in the past week. The study reveals that all five dimensions of advertising value (i.e. informativeness, credibility, entertainment, irritation, and overall advertising value) significantly influenced attitude towards the advertisement while the credibility dimension was the sole dimension of advertising value impacting attitude towards the …

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Development Of 3d Cell Culture Model For Graves’ Ophthalmopathy, Rajit Chompoowong Jan 2024

Development Of 3d Cell Culture Model For Graves’ Ophthalmopathy, Rajit Chompoowong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Orbital tissue fibrosis and remodeling contribute to the development of exophthalmos, a hallmark symptom of Graves’ ophthalmopathy (GO). The central pathogenesis to this process are orbital fibroblasts (GOF), which express autoantigen, thyroid-stimulating hormone receptor (TSHR). However, there are limitations in preclinical models for studying the pathogenesis and drug discovery of GO, which poses challenges for developing effective treatment options. This study aimed to identify markers of GOF, explore epigenetic alteration, and develop a scaffold-free 3D cell culture model for GO. The novel results from immunohistochemical analysis showed that vimentin was uniquely expressed in GO but absent in control samples. Additionally, …

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Constrained Multiview Representation For Self-Supervised Contrastive Learning, Siyuan Dai, Kai Ye, Kun Zhao, Ge Cui, Haoteng Tang, Liang Zhan Jan 2024

Constrained Multiview Representation For Self-Supervised Contrastive Learning, Siyuan Dai, Kai Ye, Kun Zhao, Ge Cui, Haoteng Tang, Liang Zhan

Computer Science Faculty Publications

Representation learning constitutes a pivotal cornerstone in contemporary deep learning paradigms, offering a conduit to elucidate distinctive features within the latent space and interpret the deep models. Nevertheless, the inherent complexity of anatomical patterns and the random nature of lesion distribution in medical image segmentation pose significant challenges to the disentanglement of representations and the understanding of salient features. Methods guided by the maximization of mutual information, particularly within the framework of contrastive learning, have demonstrated remarkable success and superiority in decoupling densely intertwined representations. However, the effectiveness of contrastive learning highly depends on the quality of the positive and …

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Spinning Spheroidal Components Of Disk Galaxies: Resonant Interactions With Stellar Bars, Xingchen Li Jan 2024

Spinning Spheroidal Components Of Disk Galaxies: Resonant Interactions With Stellar Bars, Xingchen Li

Theses and Dissertations--Physics and Astronomy

The majority of disk galaxies possess stellar bars, which are the main driver in the internal evolution of barred galaxies. Bars represent non-axisymmetric perturbations in the galactic disks, producing strong gravitational torques that facilitate angular momentum transfer from the disk to the spheroidal components, such as central stellar bulges and host dark matter (DM) halos. The redistribution of angular momentum in barred galaxies proceeds mainly via resonant interactions between the bar and orbits in the spheroids. The amount of angular momentum emitted or absorbed at each resonance depends on the mass distribution, density and spin in the spheroidal components. Thus, …

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Nonintuitive Immunogenicity And Plasticity Of Alpha-Synuclein Conformers: A Paradigm For Smart Delivery Of Neuro-Immunotherapeutics, Amos O. Abioye, Damilare Akintade, James Mitchell, Simisade Olorode, Adeboye Adejare Jan 2024

Nonintuitive Immunogenicity And Plasticity Of Alpha-Synuclein Conformers: A Paradigm For Smart Delivery Of Neuro-Immunotherapeutics, Amos O. Abioye, Damilare Akintade, James Mitchell, Simisade Olorode, Adeboye Adejare

Funded Scholarship

Despite the extensive research successes and continuous developments in modern medicine in terms of diagnosis, prevention, and treatment, the lack of clinically useful disease-modifying drugs or immunotherapeutic agents that can successfully treat or prevent neurodegenerative diseases is an ongoing challenge. To date, only one of the 244 drugs in clinical trials for the treatment of neurodegenerative diseases has been approved in the past decade, indicating a failure rate of 99.6%. In corollary, the approved monoclonal antibody did not demonstrate significant cognitive benefits. Thus, the prevalence of neurodegenerative diseases is increasing rapidly. Therefore, there is an urgent need for creative approaches …

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The Impact Of Language Status On Bilingual Language And Literacy Development, Ashley Ippolito Jan 2024

The Impact Of Language Status On Bilingual Language And Literacy Development, Ashley Ippolito

University of the Pacific Theses and Dissertations

This study investigated narrative and literacy differences between monolingual and bilingual children with Developmental Language Disorder (DLD) and examined caregivers' perspectives on their language and literacy development. This mixed methods project involved semi-structured ethnographic interviews and case histories for caregiver measures, and it included a narrative production task and a literacy skills assessment for child measures. There were two participant groups: monolingual children with a DLD in kindergarten to sixth grade (Group 1) and bilingual children (English + additional language) with a DLD (Group 2). Thematic analysis of caregiver interviews revealed that monolingual families engaged in storytelling and reading activities …

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Novel Regulators Of Small G Proteins In The Pancreatic Beta Cell, Noah Gleason Jan 2024

Novel Regulators Of Small G Proteins In The Pancreatic Beta Cell, Noah Gleason

Wayne State University Dissertations

Regulation of small GTPases within the pancreatic beta cell is a highly complex and coordinated sequence of protein interactions and post translational modifications. Various families participate in the physiological secretion of insulin in roles ranging from cytoskeletal reorganization to secretory vesicle priming and docking. However the regulatory partners of GTPase function, while studied broadly, lack vital information relating to smgGDS, a protein chaperone of small GTPases to and from the prenylation machinery, and RhoGDI function. Herein these studies are aimed to further our understanding of GTPase regulation and alterations that occur during metabolic stress (glucotoxicity) and related beta cell dysfunction.Data …

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Nostalgia, Satire, And Subcultural Capital At The Drive-In: Examining Horror Host Joe Bob Briggs As A Cultural Intermediary, Lisa Ellen Williams Jan 2024

Nostalgia, Satire, And Subcultural Capital At The Drive-In: Examining Horror Host Joe Bob Briggs As A Cultural Intermediary, Lisa Ellen Williams

Funded Scholarship

This article explores how journalist, cult icon, and Shudder host Joe Bob Briggs has used visual and verbal rhetorical devices to become a fixture in genre subcultures. Created and performed by John Bloom, the Briggs persona utilizes traits of past successful horror hosts while also implementing his own astute knowledge of film history and theory to confront questions about ‘good’ and ‘bad’ taste in film. Even though his work has been controversial, the evolution of his use of satire and parody has sustained his position as a cultural, or a subcultural, intermediary and transmedia celebrity. This article presents a variety …

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Timecraft, Mallory Fitzpatrick, Alexis G. White Jan 2024

Timecraft, Mallory Fitzpatrick, Alexis G. White

Books, pamphlets, catalogues, and scrapbooks

This catalogue serves as a permanent record for the exhibition Timecraft curated by Alexis White and Mallory Fitzpatrick in conjunction with the 14th Biennial Graduate Group Symposium on the same theme. The exhibition, which ran from November 2023 to May 2024 in Carpenter Library, challenges viewers to rethink their understanding of the way time is shaped, categorized, and created in the past, present, and future.

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Planning And Pedagogical Considerations For Teaching Children With Autism Spectrum Disorder In Physical Education, Andrew Sortwell Jan 2024

Planning And Pedagogical Considerations For Teaching Children With Autism Spectrum Disorder In Physical Education, Andrew Sortwell

Medical Papers and Journal Articles

Around the world, autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition. It is linked to a wide range of deficiencies across multiple domains, including restrictive and repetitive behaviors that impair interaction or engagement with others. School-aged children with ASD face challenges that make physical activity more difficult. To address challenges associated with ASD, physical education interventions need to be tailored to the child’s needs and abilities. Despite advances in research on children with ASD in physical education, adopting contemporary approaches is yet to be the norm. This review aimed to examine the literature on intervention models to improve the …

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Innovation In Dynamic Knowledge Landscapes: Using Topic Modelling To Map Inventive Activity And Its Implications For Financial Performance, Simon J.D. Schillebeeckx, Yimin Lin, Gerard George Jan 2024

Innovation In Dynamic Knowledge Landscapes: Using Topic Modelling To Map Inventive Activity And Its Implications For Financial Performance, Simon J.D. Schillebeeckx, Yimin Lin, Gerard George

Research Collection Lee Kong Chian School Of Business

We examine the relationship between innovation and performance in the agricultural industry by studying how a firm's patent portfolio position in the knowledge landscape moderates the relationship between three firm search dimensions (scope, specialisation, and commitment) and the firm's financial performance. To represent dynamism in the knowledge landscape, we apply topic modelling to 67,120 patent texts of 571 firms and introduce two complementary perspectives on how knowledge can be dynamically categorised. This allows us to create two representations of the knowledge structure to identify contested (scarce) clusters of high (low) recent inventive activity and emergent clusters where knowledge ambiguity has …

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A Worldwide Overview Of The Status And Prospects Of Edible Insect Production, R. Caparros Megido, F. Francis, E. Haubruge, P. Le Gall, J. K. Tomberlin, C. D. Miranda, H. R. Jordan, C. J. Picard, M. J.M. Pino, J. Ramos-Elordy, E. Katz, K. B. Barragán-Fonseca, E. M. Costa-Neto, R. Ponce-Reyes, G. Wijffels, S. Ghosh, C. Jung, Y. S. Han, B. Conti, A. Vilcinskas, C. M. Tanga, M. O. Kababu, D. Beesigamukama, J. A. Morales Ramos, A. Van Huis Jan 2024

A Worldwide Overview Of The Status And Prospects Of Edible Insect Production, R. Caparros Megido, F. Francis, E. Haubruge, P. Le Gall, J. K. Tomberlin, C. D. Miranda, H. R. Jordan, C. J. Picard, M. J.M. Pino, J. Ramos-Elordy, E. Katz, K. B. Barragán-Fonseca, E. M. Costa-Neto, R. Ponce-Reyes, G. Wijffels, S. Ghosh, C. Jung, Y. S. Han, B. Conti, A. Vilcinskas, C. M. Tanga, M. O. Kababu, D. Beesigamukama, J. A. Morales Ramos, A. Van Huis

All Peer-Reviewed Publications

There has been continuous and growing interest in edible insects. Worldwide, various levels of insect farming are emerging, ranging from small domestic farms to vertical farms reaching heights of 36 meters, accommodating several million growing insects. The appeal of insects lies in their ecological benefits, as they contribute to the valorization of unde-rutilized organic residues while requiring minimal space and water. The selection of insect species is influenced not only by their biology and behavior but also by local preferences and customs, varying with the scale of production and geographi-cal location. This review article aims to provide an updated overview …

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Editorial: 2022 In Review: Vector Biology, David P. Tchouassi, Janet Midega, Baldwyn Torto Jan 2024

Editorial: 2022 In Review: Vector Biology, David P. Tchouassi, Janet Midega, Baldwyn Torto

All Peer-Reviewed Publications

This editorial summarizes collections on the Research Topic “2022 in Review: Vector Biology’’ that focus on entomologic surveillance insights related to mosquito-borne diseases such as dengue and malaria, and sandfly-borne leishmaniasis. Specifically, the editorial discusses the entomologic drivers of dengue virus transmission, host-feeding relationships among various mosquito vectors, sample efficiency of malaria vectors using a suite of trapping techniques and improving sandfly surveillance using odor-baited trapping strategies. The research article by Kamau et al. assessed variation in the biological attributes of adult Aedes aegypti mosquitoes by estimating critical parameters of vectorial capacity (vectors abundance, human blood feeding rates, survival) that …

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Effects Of Four Potent Entomopathogenic Fungal Isolates On The Survival And Performance Of Telenomus Remus, An Egg Parasitoid Of Fall Armyworm, Junitor Chepkemoi, Ken Okwae Fening, Felicitas Chaba Ambele, Joseph Munywoki, Komivi Senyo Akutse Jan 2024

Effects Of Four Potent Entomopathogenic Fungal Isolates On The Survival And Performance Of Telenomus Remus, An Egg Parasitoid Of Fall Armyworm, Junitor Chepkemoi, Ken Okwae Fening, Felicitas Chaba Ambele, Joseph Munywoki, Komivi Senyo Akutse

All Peer-Reviewed Publications

Fall armyworm (FAW), Spodoptera frugiperda is a generalist pest known to feed on more than 300 plant species, including major staple crops such as rice, maize and sorghum. Biological control of FAW using a combination of a major indigenous egg parasitoid Telenomus remus and entomopathogenic fungi was explored in this study. Metarhizium anisopliae strains (ICIPE 7, ICIPE 41, and ICIPE 78) and Beauveria bassiana ICIPE 621 which demonstrated effectiveness to combat the pest, were evaluated through direct and indirect fungal infection to assess their pathogenicity and virulence against T. remus adults, S. frugiperda eggs and their effects on T. remus …

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Usp22 Overexpression Fails To Augment Tumor Formatiaon In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou Jan 2024

Usp22 Overexpression Fails To Augment Tumor Formatiaon In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

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Comparison Of Test Performance Of A Conventional Pcr And Two Field-Friendly Tests To Detect Coxiella Burnetii Dna In Ticks Using Bayesian Latent Class Analysis, Maureen W. Kamau, Carmel Witte, Wynand Goosen, Mathew Mutinda, Jandouwe Villinger, Dennis Getange, Rua Khogali, Michael E. Von Fricken, Eric Maurice Fèvre, Dawn Zimmerman, Yvonne Marie Linton, Michele Miller Jan 2024

Comparison Of Test Performance Of A Conventional Pcr And Two Field-Friendly Tests To Detect Coxiella Burnetii Dna In Ticks Using Bayesian Latent Class Analysis, Maureen W. Kamau, Carmel Witte, Wynand Goosen, Mathew Mutinda, Jandouwe Villinger, Dennis Getange, Rua Khogali, Michael E. Von Fricken, Eric Maurice Fèvre, Dawn Zimmerman, Yvonne Marie Linton, Michele Miller

All Peer-Reviewed Publications

Introduction: Coxiella burnetii (C. burnetii)-infected livestock and wildlife have been epidemiologically linked to human Q fever outbreaks. Despite this growing zoonotic threat, knowledge of coxiellosis in wild animals remains limited, and studies to understand their epidemiologic role are needed. In C. burnetii-endemic areas, ticks have been reported to harbor and spread C. burnetii and may serve as indicators of risk of infection in wild animal habitats. Therefore, the aim of this study was to compare molecular techniques for detecting C. burnetii DNA in ticks. Methods: In total, 169 ticks from wild animals and cattle in wildlife conservancies in northern Kenya …

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A Global Database Of Dissolved Organic Matter (Dom) Concentration Measurements In Coastal Waters (Coastdom V1), Christian Lønborg, Cátia Carreira, Gwenaël Abril, Susana Agustí, Valentina Amaral, Agneta Andersson, Javier Arístegui, Punyasloke Bhadury, Mariana B. Bif, Alberto V. Borges, Steven Bouillon, Maria Ll. Calleja, Jr., Luiz Cotovicz Jr., Stefano Cozzi, Maryló Doval, Carlos M. Duarte, Bradley Eyre, Cédric G. Fichot, E. Elena García-Martín, Alexandra Garzon-Garcia, Michele Giani, Rafael Gonçalves-Araujo, Renee Gruber, Dennis A. Hansell, Fuminori Hashihama, Ding He, Johnna M. Holding, William R. Hunter, J. Severino Ibánhez, Valeria Ibello, Shan Jiang, Guebuem Kim, Katja Klun, Piotr Kowalczuk, Atsushi Kubo, Choon-Weng Lee, Cláudia B. Lopes, Federica Maggioni, Paolo Magni, Celia Marrase, Patrick Martin, S. Leigh Mccallister, Roisin Mccallum, Patricia M. Medeiros, Xosé Anxelu Morán, Frank E. Muller-Karger, Allison Myers-Pigg, Marit Norli, Joanne M. Oakes, Helena Osterholz, Hyekyung Park, Paulsen, Maria Lund Paulsen, Judith A. Rosentreter, Jeff D. Ross, Digna Rueda-Roa, Chiara Santinelli, Yuan Shen, Eva Teira, Tinkara Tinta, Guenther Uher, Masahide Wakita, Nicholas Ward, Kenta Watanabe, Yu Xin, Youhei Yamashita, Liyang Yang, Jacob Yeo, Huamao Yuan, Qiang Zheng, Xosé Antón Álvarez-Salgado Jan 2024

A Global Database Of Dissolved Organic Matter (Dom) Concentration Measurements In Coastal Waters (Coastdom V1), Christian Lønborg, Cátia Carreira, Gwenaël Abril, Susana Agustí, Valentina Amaral, Agneta Andersson, Javier Arístegui, Punyasloke Bhadury, Mariana B. Bif, Alberto V. Borges, Steven Bouillon, Maria Ll. Calleja, Jr., Luiz Cotovicz Jr., Stefano Cozzi, Maryló Doval, Carlos M. Duarte, Bradley Eyre, Cédric G. Fichot, E. Elena García-Martín, Alexandra Garzon-Garcia, Michele Giani, Rafael Gonçalves-Araujo, Renee Gruber, Dennis A. Hansell, Fuminori Hashihama, Ding He, Johnna M. Holding, William R. Hunter, J. Severino Ibánhez, Valeria Ibello, Shan Jiang, Guebuem Kim, Katja Klun, Piotr Kowalczuk, Atsushi Kubo, Choon-Weng Lee, Cláudia B. Lopes, Federica Maggioni, Paolo Magni, Celia Marrase, Patrick Martin, S. Leigh Mccallister, Roisin Mccallum, Patricia M. Medeiros, Xosé Anxelu Morán, Frank E. Muller-Karger, Allison Myers-Pigg, Marit Norli, Joanne M. Oakes, Helena Osterholz, Hyekyung Park, Paulsen, Maria Lund Paulsen, Judith A. Rosentreter, Jeff D. Ross, Digna Rueda-Roa, Chiara Santinelli, Yuan Shen, Eva Teira, Tinkara Tinta, Guenther Uher, Masahide Wakita, Nicholas Ward, Kenta Watanabe, Yu Xin, Youhei Yamashita, Liyang Yang, Jacob Yeo, Huamao Yuan, Qiang Zheng, Xosé Antón Álvarez-Salgado

Marine Science Faculty Publications

Measurements of dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) concentrations are used to characterize the dissolved organic matter (DOM) pool and are important components of biogeochemical cycling in the coastal ocean. Here, we present the first edition of a global database (CoastDOM v1; available at https://doi.org/10.1594/PANGAEA.964012, Lønborg et al., 2023) compiling previously published and unpublished measurements of DOC, DON, and DOP in coastal waters. These data are complemented by hydrographic data such as temperature and salinity and, to the extent possible, other biogeochemical variables (e.g. chlorophyll a, inorganic nutrients) and the inorganic carbon system (e.g. dissolved inorganic carbon …

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Hypoxia-Adenosine Axis As Therapeutic Targets For Acute Respiratory Distress Syndrome, Katherine Figarella, Jieun Kim, Wei Ruan, Tingting Mills, Holger Klaus Eltzschig, Xiaoyi Yuan Jan 2024

Hypoxia-Adenosine Axis As Therapeutic Targets For Acute Respiratory Distress Syndrome, Katherine Figarella, Jieun Kim, Wei Ruan, Tingting Mills, Holger Klaus Eltzschig, Xiaoyi Yuan

Faculty, Staff and Student Publications

The human respiratory and circulatory systems collaborate intricately to ensure oxygen delivery to all cells, which is vital for ATP production and maintaining physiological functions and structures. During limited oxygen availability, hypoxia-inducible factors (HIFs) are stabilized and play a fundamental role in maintaining cellular processes for hypoxia adaptation. First discovered during investigations of erythropoietin production regulation, HIFs influence physiological and pathological processes, including development, inflammation, wound healing, and cancer. HIFs promote extracellular adenosine signaling by enhancing adenosine generation and receptor signaling, representing an endogenous feedback mechanism that curbs excessive inflammation, supports injury resolution, and enhances hypoxia tolerance. This is especially …

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First Evidence Of Microplastic Inhalation Among Free-Ranging Small Cetaceans, Miranda K Dziobak, Andreas Fahlman, Randall S Wells, Ryan Takeshita, Cynthia Smith, Austin Gray, John Weinstein, Leslie B Hart Jan 2024

First Evidence Of Microplastic Inhalation Among Free-Ranging Small Cetaceans, Miranda K Dziobak, Andreas Fahlman, Randall S Wells, Ryan Takeshita, Cynthia Smith, Austin Gray, John Weinstein, Leslie B Hart

Faculty, Staff and Student Publications

Plastic is a ubiquitous environmental contaminant, resulting in widespread exposure across terrestrial and marine spaces. In the environment, plastics can degrade into microparticles where exposure has been documented in a variety of fauna at all trophic levels. Human epidemiological studies have found relationships between inhaled microplastics and oxidative stress and inflammation. Previous studies of bottlenose dolphins (Tursiops truncatus) have reported prevalent exposure to plasticizing chemicals (e.g., phthalates) as well as particle loads in gastrointestinal tracts, but exposure from inhalation has not yet been studied. The objective of this study was to determine if inhalation is a viable route of microplastic …

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Multiple Unfolded Protein Response Pathways Cooperate To Link Cytosolic Dsdna Release To Stimulator Of Interferon Gene Activation, Tiancheng Hu, Yiping Liu, Jeremy Fleck, Cason King, Elaine Schalk, Zhenyu Zhang, Andrew Mehle, Judith A Smith Jan 2024

Multiple Unfolded Protein Response Pathways Cooperate To Link Cytosolic Dsdna Release To Stimulator Of Interferon Gene Activation, Tiancheng Hu, Yiping Liu, Jeremy Fleck, Cason King, Elaine Schalk, Zhenyu Zhang, Andrew Mehle, Judith A Smith

Faculty, Staff and Student Publications

The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in responses to "sterile" endogenous threats and pathogens without nominal DNA or cyclic di-nucleotide stimuli. Previous work showed an endoplasmic reticulum (ER) stress response, known as the unfolded protein response (UPR), activates STING. Herein, we sought to determine if ER stress generated a STING ligand, and to identify the UPR pathways involved. Induction of IFN-β expression following stimulation with the UPR inducer thapsigargin (TPG) or oxygen glucose deprivation required both STING and the dsDNA-sensing cyclic GMP-AMP synthase (cGAS). Furthermore, TPG increased cytosolic mitochondrial DNA, and immunofluorescence visualized dsDNA punctae in …

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