Digital Commons Network^™

Homozygous Variants In Wdr83os Lead To A Neurodevelopmental Disorder With Hypercholanemia, Scott Barish, Sheng-Jia Lin, Reza Maroofian, Alper Gezdirici, Hamoud Alhebby, Aurélien Trimouille, Marta Biderman Waberski, Tadahiro Mitani, Ilka Huber, Kristian Tveten, Øystein L Holla, Øyvind L Busk, Henry Houlden, Ehsan Ghayoor Karimiani, Mehran Beiraghi Toosi, Reza Shervin Badv, Paria Najarzadeh Torbati, Fatemeh Eghbal, Javad Akhondian, Ayat Al Safar, Abdulrahman Alswaid, Giovanni Zifarelli, Peter Bauer, Dana Marafi, Jawid M Fatih, Kevin Huang, Cassidy Petree, Daniel G Calame, Charlotte Von Der Lippe, Fowzan S Alkuraya, Sami Wali, James R Lupski, Gaurav K Varshney, Jennifer E Posey, Davut Pehlivan

Faculty, Staff and Students Publications

WD repeat domain 83 opposite strand (WDR83OS) encodes the 106-aa (amino acid) protein Asterix, which heterodimerizes with CCDC47 to form the PAT (protein associated with ER translocon) complex. This complex functions as a chaperone for large proteins containing transmembrane domains to ensure proper folding. Until recently, little was known about the role of WDR83OS or CCDC47 in human disease traits. However, biallelic variants in CCDC47 were identified in four unrelated families with trichohepatoneurodevelopmental syndrome, characterized by a neurodevelopmental disorder (NDD) with liver dysfunction. Three affected siblings in an additional family share a homozygous truncating WDR83OS variant and a phenotype of …

A Unified Multimodal Video Conference Annotator For Real-Time Llm Applications, Yu-Chung Hsiao

Defensive Publications Series

A multimodal annotator is proposed herein that provides multimodal signals including slide presentations, facial expressions, speech tones, sentiment analysis, and join/leave metadata in addition to ordinary text meeting transcripts. The multimodal annotator may enable real-time multimodal Large Language Model (LLM) applications and can be implemented as a drop-in replacement for generating text transcripts in existing LLM applications. Thus, the multimodal annotator as proposed herein can enable more advanced, multimodal artificial intelligence (AI) assistant features for that can be used across a variety of use cases, such as for video conference use cases, call center use cases, presentation video recordings, or …

Vol. 36, No. 10 - Whole No. 211, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 36, No. 8 - Whole No. 209, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 36, No. 6 - Whole No. 207, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 36, No. 3 - Whole No. 204, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 36, No. 1 - Whole No. 202, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Applications In The Classroom: Teaching Disney/Pixar’S Inside Out Within The Tradition Of Allegorical Personification, Jason John Gulya

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Several years ago, I noticed that the widespread distinction between high and low culture was wreaking havoc on my classroom. My students would read and analyze texts like Robinson Crusoe and Pride and Prejudice with little to no prompting because (in their minds) these texts were already part of the recognized canon and it was therefore permissible to pick them apart and analyze them closely. But I would get strange looks when I asked undergraduates to think critically about how the mock-news programs The Daily Show and The Colbert Report worked or when I asked them to discuss how the …

More Than Simple Plagiarism: Ligotti, Pizzolatto, And True Detective’S Terrestrial Horror, Jonathan Elmore

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Of course, True Detective is neither a philosopher’s bedtime story nor supernatural horror, and yet there remains a productive affinity between Ligotti’s work and the HBO series. Where Ligotti provides substantial portions of the hallmark character’s identity and dialogue, True Detective puts Ligotti’s thought experiment to far more practical uses than does Ligotti himself. By intertwining hurricanes and flooding alongside industry and pollution into the background and negative space of the setting, the series implicates the urgent material reality of climate change and environmental collapse into the setting: “all of this is going to be under water in thirty years” …

Artificial Intelligence Driven Pile User Interface For Selection And Triage Of Digital Content, Ajay Prasad, Sunil Samuel, Sanika Barve

Defensive Publications Series

The current process of selecting and managing photos via digital galleries is cumbersome and inefficient because users must manually scroll through a large number of photos, assess each photo by opening it individually, and decide relevant actions. This process can detract from the enjoyment of viewing and sharing photos. This disclosure describes techniques for streamlining the selection and organization of multiple photos into a virtual pile by dragging and dropping them into an AI-powered dynamic UI element on screen. Generative AI is applied to the photos in the pile to automate various photo-related edits and tasks. Users can expand the …

Michigan Academician, Volume 48, Issue 2

Michigan Academician

No abstract provided.

Michigan Academician, Volume 48, Issue 3

Michigan Academician

No abstract provided.

Likert Scale Variables In Personal Finance Research: The Neutral Category Problem, Blain Pearson, Donald Lacombe, Nasima Khatun

Finance and Economics

Personal finance research often utilizes Likert-type items and Likert scales as dependent variables, frequently employing standard probit and ordered probit models. If inappropriately modeled, the "neutral" category of discrete dependent variables can bias estimates of the remaining categories. Through the utilization of hierarchical models, this paper demonstrates a methodology that accounts for the econometric issues of the neutral category. We then analyze the technique through an empirical exercise relevant to personal finance research using data from the National Financial Capability Study. We demonstrate that ignoring the "neutral" category bias can lead to incorrect inferences, hindering the progression of personal finance …

What Can We Learn From Cavity-Nesting Birds?, Jennifer Uehling

Sustainability Research & Practice Seminar Presentations

Professor Jennifer Uehling, Biology, "What can we learn from cavity-nesting birds?".

The Lumberjack, November 06, 2024

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Management Of Aorto-Right Ventricular Fistulas After Tavr, Ricardo Chia, Chamaka Kalutota, Kerry Cao, Steven Douedi, William Chang, Dominic Pinciotti, Mohammad Beizaeipour, Jennifer Joiner, Daniel Ice, Ronald Ross, Richard Kovach, Chunguang Chen, Muhammad Raza

Division of Cardiology Faculty Papers

This clinical case series reviews the diagnosis and management of aorto-right ventricular fistulas post-transcatheter aortic valve replacement, highlighting 3 cases. We emphasize early detection, individualized treatment strategies, and the role of multidisciplinary heart teams in achieving favorable outcomes. Comprehensive imaging and procedural planning are crucial for successful intervention and management of this rare complication.

Biofabrication Of Tissue Constructs Using Protein-In-Polysaccharide Bioinks For Muscle Regeneration, Harshavardhan B

Theses and Dissertations

Myocardial infarction (MI) and volumetric muscle loss (VML) are debilitating conditions that severely affect patient quality of life and challenge healthcare systems, particularly in diagnosis and treatment. Conventional therapies often result in long recovery periods with limited functional restoration. Advances in regenerative medicine, especially extrusion-based 3D bioprinting, offer promising potential to improve the regeneration of complex tissues by precisely depositing cells and biomaterials layer-by-layer to create tailored tissue constructs.

A critical challenge in muscle tissue regeneration is developing protein-polysaccharide bioinks that closely mimic the native muscle tissue microenvironment. In this study, two protein-inpolysaccharide bioinks (alginate-fibrinogen and methylcellulose-gelatin-alginate) were developed to …

Americans Face Migration: A Comparative Study Of State Immigration Policy By Region, 1865-1925, Brett S. Janos

History ETDs

This dissertation challenges the prevailing narrative of U.S. immigration policy by examining the pivotal role of state governments in shaping immigration patterns and regulations during the late 19th and early 20th centuries. Through a comprehensive regional analysis, this study highlights the diverse approaches taken by different states in attracting and managing immigrant populations. The research demonstrates the complex interplay between local, state, and federal authorities by comparing state-level policies.

This multi-layered approach reveals the ingenuity of state immigration boards and commissions and the complex interplay between state desires, regional characteristics, and the evolving federal response. Moreover, a vital contribution of …

Lactobacillus Rhamnosus Modulates Murine Neonatal Gut Microbiota And Inflammation Caused By Pathogenic Escherichia Coli., Hao Xuan, Shahid Umar, Cuncong Zhong, Wei Yu, Ishfaq Ahmed, Joshua Wheatley, Venkatesh Sampath, Susana Chavez-Bueno

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Pathogenic Escherichia coli strains produce neonatal septicemia after colonizing the neonatal gut. While the probiotic Lactobacillus rhamnosus GG (LGG) effectively reduces neonatal sepsis, LGG's effects on the neonatal intestinal microbiota alterations and inflammation triggered by E. coli are incompletely understood. We hypothesized that LGG significantly modulates the specific neonatal gut microbial populations changes and the inflammatory response elicited by the enteral introduction of septicemia-producing E. coli. To test this hypothesis, newborn rats were pretreated orally with LGG or placebo prior to infection with the neonatal E. coli septicemia clinical isolate SCB34. Amplicon 16S rRNA gene sequencing was performed on …

Successful Transcatheter Mitral Valve Mass Extraction With Complete Resolution Of The Severe Mitral Regurgitation, Hussam Al Hennawi, Ahmad Abulshamat, Shaurya Srivastava, Mohammed Qintar

Abington Jefferson Health Papers

Interest has arisen in exploring the off-label application of left-sided percutaneous mechanical aspiration, where conventional management strategies may not suffice. Percutaneous mechanical aspiration has been shown to be effective as a diagnostic and therapeutic intervention in select patients with infective endocarditis. This paper hereby reports the first case of a successful transeptal large bore manual aspiration device (AlphaVac; Angiodynamics) for nonbacterial thrombotic endocarditis with total resolution of associated severe mitral valve regurgitation.

Ani219 Project 2 Example 1, Sae University College

Exemplars

ANI219 Project 2 34T3 student submission.

Counseling Iowan Farmers: A Phenomenological Study Of Clinical Perspectives, Kathleen Ruscitto, Corinne W. Bridges

Journal of Social, Behavioral, and Health Sciences

Rural communities present unique challenges for counselors. Farmers experience high rates of suicidality, depression, and substance abuse and are less likely to seek mental health help due to associated stigma, financial strain, time constraints, and lack of specialized training among clinicians. This study sought to understand the lived experiences of counselors in rural Iowa who counsel male farmers. Participants completed a 60-minute semi-structured interview and demographics questionnaire. Hermeneutic phenomenology and the ecological perspective were used to identify and interpret these experiences, illuminating the need for culturally competent, contextually responsive counseling practices in rural settings. Essential themes were categorized within the …

November 6 ,2024, The Dakota Student

The Dakota Student

No abstract provided.

Historical Trends In Macro-Jurisprudence: A Language Model Assessment, 1870–2023, Edward H. Stiglitz, Rosamond Thalken

Maryland Law Review

No abstract provided.

The Costs Of Ecosystem Disturbances, E. Wesley F. Peterson

Cornhusker Economics

Presents an illustration of the interdependencies inherent in natural ecosystems. An ecosystem may be defined as: “… a single environment and every living (biotic) organism and non-living (abiotic) factor that is contained within it or characterizes it. An ecosystem embodies every aspect of a single habitat, including all interactions between its different elements” (Knapp 2020). In such interdependent systems, removal of one or more of the essential “elements” can severely disrupt the functioning of the system and such disruptions can give rise to negative impacts on the environment and human health and well-being.

Skn-1 Activation During Infection Of Caenorhabditis Elegans Requires Cdc-48 And Endoplasmic Reticulum Proteostasis, Carolaing Gabaldón, Ozgur Karakuzu, Danielle A Garsin

Faculty, Staff and Student Publications

During challenge of Caenorhabditis elegans with human bacterial pathogens such as Pseudomonas aeruginosa and Enterococcus faecalis, the elicited host response can be damaging if not properly controlled. The activation of Nrf (nuclear factor erythroid-related factor)/CNC (Cap-n-collar) transcriptional regulators modulates the response by upregulating genes that neutralize damaging molecules and promote repair processes. Activation of the C. elegans Nrf ortholog, SKN-1, is tightly controlled by a myriad of regulatory mechanisms, but a central feature is an activating phosphorylation accomplished by the p38 mitogen-activated kinase (MAPK) cascade. In this work, loss of CDC-48, an AAA+ ATPase, was observed to severely compromise SKN-1 …

A Distributed Secure System For Threads Detection In Crowded Environments Based On Biometric Facial Expression, Nourhan Zayed, Hassan I. Sayed, Ghada F. El-Kabbany

Mechanical Engineering

Ensuring security in crowded areas poses a significant problem due to the dense population and the intricate task of monitoring their behaviors. This research presents a real-time security system that utilizes facial expression analysis to identify potential threats. The technology utilizes sophisticated facial recognition and emotion detection techniques to accurately recognize emotions such as wrath, fear, and anxiety. These feelings can serve as indicators of suspicious activities or potential security risks. The system utilizes a Convolutional Neural Network (CNN) to classify facial expressions and recognize objects. In addition, it integrates an SVM classifier trained on features derived from the combined …

Failure In A Population: Tauopathy Disrupts Homeostatic Set-Points In Emergent Dynamics Despite Stability In The Constituent Neurons, James N Mcgregor, Clayton A Farris, Sahara Ensley, Aidan Schneider, Leandro J Fosque, Chao Wang, Elizabeth I Tilden, Yuqi Liu, Jianhong Tu, Halla Elmore, Keenan D Ronayne, Ralf Wessel, Kiran Bhaskaran-Nair, David M Holtzman, Keith B Hengen, Et Al.

2020-Current year OA Pubs

Homeostatic regulation of neuronal activity is essential for robust computation; set-points, such as firing rate, are actively stabilized to compensate for perturbations. The disruption of brain function central to neurodegenerative disease likely arises from impairments of computationally essential set-points. Here, we systematically investigated the effects of tau-mediated neurodegeneration on all known set-points in neuronal activity. We continuously tracked hippocampal neuronal activity across the lifetime of a mouse model of tauopathy. We were unable to detect effects of disease in measures of single-neuron firing activity. By contrast, as tauopathy progressed, there was disruption of network-level neuronal activity, quantified by measuring neuronal …

2024-11-06 The Flat Earthers Are Back, And They’Ve Found Jazz!, Milan Damjanac

The Spectator Online

No abstract provided.

2024-11-06 Redhawk Rewind: The History Of Seattle University’S Mascot, Tristan Scott

The Spectator Online

No abstract provided.