Digital Commons Network^™

Protecting Global Health Partnerships In The Era Of Destructive Nationalism, Maya Adam, Desiree Labeaud, Nokwanele Mbewu, Jennifer Gates, Randall Waechter, Mercy Borbor-Cordova, Lydiah Kibe, Sonia Alvarez, Annie Dori, Anil Bilimale, Meggie Mwoka, Jessica Deffler, Michele Spring, Avriel Diaz, Rachael Farquhar, Willy Dunbar, Comfort Phiri, Valerie Luzadis, Nicole Redvers, Cristina Alonso, Rosemary Rochford, Rachel Lowe, Kareem Coomansingh, Moses Laman, Rebeca Sultana, Sadie Ryan, Amaya Bustinduy, Anita Hargrave-Bouagnon, Shazia Ruybal-Pesántez, Zebedee Kerry, Trevor Kelebi, Samuel Mcewen, Leanne Robinson, Maritza Salazar Campo, Till Bärnighausen

Department of Family & Community Medicine Faculty Papers

No abstract provided.

The Unconstitutional Impact Of Anti-Transgender Legislation On Native Hawaiians, Aaliah Moi-Matsumoto

Seattle Journal for Social Justice

No abstract provided.

Gpat4 Sustains Endoplasmic Reticulum Homeostasis In Endocardial Cells And Safeguards Heart Development, Tianyang Zhao, Kuipei Jin, Xiaodong Wang, Xiong Su, Youjun Wang, Mingming Gao, Wen Luo, Hongyuan Yang, Zhongzhou Yang

Faculty, Staff and Student Publications

The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic reticulum (ER) membrane anchored protein. While the role of GPAT4 in glycerophospholipid biosynthesis is well established, its function in the ER is less explored. Here, we generate Gpat4 global and tissue-specific knockout mice and identify the essential role of GPAT4 in endocardial development. Deficiency of GPAT4 provokes endocardial ER stress response and enhances ER-mitochondrial (ER-mito) communications, leading to mitochondrial DNA (mtDNA) escape. As a result, the cGAS-STING pathway is triggered to stimulate …

"In Art Things Are Either Necessary Or Superfluous", Fernando Zóbel De Ayala

Perspectives in the Arts and Humanities Asia

No abstract provided.

Molecular Subtyping Of Hypertensive Disorders Of Pregnancy, Michal Elovitz, Elaine Gee, Nathaniel Delaney-Busch, Alison Moe, Mitsu Reddy, Arkady Khodursky, Johnny La, Ilma Abbas, Kay Mekaru, Hunter Collins, Farooq Siddiqui, Rory Nolan, Rupsa Boelig, Daniel Kiefer, Pamela Simmons, George Saade, Antonio Saad, Ebony Carter, Thomas Mcelrath, Stephen Quake, Mark Depristo, Carrie Haverty, Manfred Lee, Eugeni Namsaraev, Vincenzo Berghella, Ai-Ris Collier, Antonia Frolova, Esther Park-Hwang, Luis Pacheco, Elizabeth Sutton, Maneesh Jain, Kara Rood, William A Grobman, Joseph Biggio, Cynthia Gyamfi-Bannerman, Arun Jeyabalan, Morten Rasmussen

Department of Obstetrics and Gynecology Faculty Papers

Hypertensive disorders of pregnancy (HDP), including preeclampsia, affect 1 in 6 pregnancies, are major contributors to maternal morbidity and mortality, yet lack precision medicine strategies. Analyzing transcriptomic data from a prospectively-collected diverse cohort (n = 9102), this study reveals distinct RNA subtypes in maternal blood, reclassifying clinical HDP phenotypes like early/late-onset preeclampsia. The placental gene PAPPA2 strongly predicts the most severe forms of preeclampsia in individuals without pre-existing high risk factors, months before symptoms, and its overexpression correlates with earlier delivery in a dose-dependent manner. Further, molecular subtypes characterized by immune genes are upregulated in less severe forms of HDP. …

Rewilding: Native Gardening For The Pacific Northwest And North Coast, Peter Haggard, Jane Monroe

Textbooks and Manuals Series

Think of this book as a tool that will guide you through the journey of transforming your yard or lawn into a resilient garden landscape filled with vibrant native plants and endemic wildlife. Dig into a new way of gardening—one that nurtures not just your plants, but the planet. This book is for gardeners who want to get their hands dirty while creating thriving habitats for native wildlife. Whether you’re replacing bird feeders with natural food sources, growing your own produce while boosting biodiversity, or transforming urban and suburban spaces into havens for indigenous species, this guide will inspire you …

Protpen: A Pipeline That Combines Sequence- And Structure-Based Approaches To Predict Protein Functions, Diya Mathai

Theses

Proteins of unknown function represent a significant gap in our understanding of biological processes, with many organisms, especially prokaryotes, harboring large portions of their proteomes that remain uncharacterized. For example, in Pseudomonas aeruginosa, a major human pathogen, a large proportion of proteins are categorized as unknown or hypothetical in function. The precise number varies across species, but studies have shown that up to 30–50% of proteins in bacterial proteomes can lack functional annotations. Addressing this gap is critical to understanding the biology and pathogenicity of such organisms. Recent advancements in computational tools, particularly those in sequence and structure-based prediction, offer …

The Cardiovascular Care Of The Pediatric Athlete, Peter N Dean, Julie A Brothers, Kristin Burns, Jonathan B Edelson, Susan Etheridge, Dermot M Phelan, Keri Shafer, Chris Snyder, Silvana Molossi, Alfred Danielian, Eli M Friedman, Jeff Hsu, Mustafa Husaini, Eugene H Chung, Matthew W Martinez, Aaron L Baggish, Benjamin D Levine, Jonathan H Kim, American College Of Cardiology Sports & Exercise Cardiology Council

Faculty, Staff and Students Publications

Sports cardiology broadly encompasses the cardiovascular care of individuals who place a high premium on habitual exercise, sports performance, and/or sports competition. Some of the essential aspects within sports cardiology include the preparticipation cardiac evaluation and the management of cardiac diseases in athletes. Although most sports cardiology practitioners are trained in adult cardiology, a significant number of individuals who participate in sports are pediatric-aged, < 18 years old. Up to two-thirds of children in middle and high school participate in organized sports or are involved in nonorganized recreational sports. The cardiovascular care of pediatric-aged athletes can be challenging because many of the classic tenets and principles in adult sports cardiology do not fully generalize to pediatrics, and there is a lack of the evidence base that may be present for adult athletes. The epidemiology, presentation, and progression of cardiovascular diseases can be significantly different between pediatric and adult athletes. The evaluation of potential diseases and management considerations may also differ between pediatric and adult athletes. Similar to adults, there are "gray zones" where it is difficult to differentiate between normal exercise-induced cardiac remodeling and true cardiac pathology, but the additional lack of normative standards further complicates assessments in pediatric athletes. Management decisions for pediatric athletes are generally based on limited data but carry substantial short- and long-term implications. Thus, shared decision-making as part of the determination of clinical management strategies and for sports participation is critical and requires the participation of the parents or guardian(s). In this state-of-the-art review, key differences between pediatric and adult-aged athletes are highlighted. Specifically, how to define the "pediatric athlete," consider cardiovascular adaptations observed among pediatric athletes, determine preparticipation screening options and optimal symptom-driven evaluations in children, and consider best practices for pediatric athletes with several key cardiac conditions are detailed. The purpose of this document is to represent the first primary reference available to providers who care for pediatric athletes with cardiovascular concerns.

The Lynmouth Flood Disaster As A ‘Rural Enterprise Metabolic Rift’ And Securitising Rural Regions Against Future Hazards Of Planetary Collapse, Orlando Goodall

School of Law, Humanities and Social Sciences

This article advances a novel synthesis of two critical theoretical positions to reinterpret the Lynmouth flood disaster of 1952 – an event which caused the deaths of 34 people. Rural enterprise criminology and the metabolic rift concept are brought into dialogue to elaborate a foundation from which to articulate the multifactorial process that eventuated in the flood. The article fills an absence in the social sciences on the significant loss of life that moves beyond descriptive narratives of the tragedy and dated positivist epistemology. The article displaces determinist explanations of natural science and popular invocations of ‘acts of God’ and …

Nbeal2 Knockout Mice Are Not Protected Against Hypoxia-Induced Pulmonary Vascular Remodeling And Pulmonary Hypertension, Janelle N Posey, Mariah Jordan, Caitlin V Lewis, Christina Sul, Evgenia Dobrinskikh, Delaney Swindle, Frederik Denorme, David Irwin, Jorge Di Paola, Kurt Stenmark, Eva S Nozik, Cassidy Delaney

2020-Current year OA Pubs

Inflammation drives the initiation and progression of pulmonary hypertension (PH). Platelets, increasingly recognized as immune cells, are activated and increased in the lungs of patients with PH. Platelet activation leads to the release of α-granule chemokines, many of which are implicated in PH. We hypothesized that hypoxia-induced secretion of platelet α-granule-stored proteins and PH would be prevented in Neurobeachin-like 2 knockout (Nbeal2-/-) α-granule-deficient mice. Wild-type (WT) and Nbeal2-/- mice were maintained in normoxia or exposed to 10% hypobaric hypoxia for 3, 14, 21, or 35 days. We observed macrothrombocytopenia, increased circulating neutrophils and monocytes, and increased lung interstitial macrophages (IMs) …

70 - Unmeasured Confounding In Meta-Analyses Of Observational Studies Evaluating Maternal Periodontitis And Adverse Birth Outcomes, May Salama, Abdullah Al-Taiar, Denise Claiborne, Anwar Merchant

Undergraduate Research Symposium

Background: Maternal periodontitis has been consistently linked to adverse birth outcomes (ABOs). However, a causal relationship is not established due to potential unmeasured confounding factors in observational studies and inconclusive results from randomized controlled trials. This study aimed to assess the impact of unmeasured confounding factors in meta-analyses examining associations between maternal periodontitis and preterm birth (PTB) or low birth weight (LBW).

Methods: PubMed and MEDLINE, Cochrane, Embase, and Google Scholar were searched for systematic reviews with meta-analyses of observational studies between 2002 and 2023. Systematic reviews with meta-analyses of observational studies were included if either PTB or LBW were …

Predicting Capture And Survival Probabilities Of The Arizona Tiger Salamander: A Comparison Of Capture-Recapture Models, Brittney Nelson

Scholars Week

Capture-recapture models are essential tools for estimating population dynamics in ecological studies. A fundamental component of these models is the capture history matrix, which records individual detection over time and serves as the basis for estimating survival and capture probabilities. This presentation explores three statistical approaches to these estimations: the Cormack-Jolly-Seber (CJS) model, the Hidden Markov Model (HMM) for CJS, and the Bayesian CJS model. The CJS model provides a likelihood-based framework for estimation, and the HMM CJS incorporates latent states into the model to account for uncertainty in detection. The Bayesian CJS extends this same analysis by integrating prior …

Sample Storage Method And Collection Time Effects On Horse Hair Cortisol Concentrations, Grace Robertson

Scholars Week

Serum cortisol concentration is the gold standard for evaluating stress in horses. However, it can be affected by circadian rhythms, environmental factors, and other excitatory events. Hair cortisol is less subject to these variables and is less invasive to collect, but there is a lack of published information on hair cortisol concentrations in horses. The objectives of this study were to examine 1) the impact of sample storage (Room temperature vs. Frozen) and 2) the effect of collection date (spring vs. fall), on cortisol concentration in equine hair. It was hypothesized that Frozen samples would yield higher concentrations than Room …

Comparative Analysis Of Leaf Tissue And Soil Composition: Evaluating Nutrient Dynamics In Agricultural Systems Utilizing Composted Manures Versus Commercial Fertilizer, Chandralekha Joga Miss

Scholars Week

No abstract provided.

Economics Of Controlling Weeds Of Permanent Pasture, I Popay, N Barlow

IGC Proceedings (1977-2023)

In general, inedible weeds of permanent pasture reduce pas­ture dry matter available to stock in direct proportion to their cover (Doyle et al., 1984). Translating the effects of weeds on pasture to reductions in animal production is difficult because (i) pasture value can range from zero to the cost of purchased feed (ii) weed effects and pasture value can vary seasonally and interact and (iii) reductions in pasture availability at one time affect later growth (Auld et al., 1987). There have been few direct measurements of effects of pasture weeds on animal pro­ductivity, because of the co.sts involved. However, simulation …

Variation In Hypericum Perforatum L. In Australia, M H. Campbell, C E. May, I A. Southwell, J D. Tomlinson

IGC Proceedings (1977-2023)

In Australia Hypericum perforatum (St. John's wort) is a major weed of pastures because it replaces useful vegetation, causes photosensitisation in grazing animals, depresses their central nervous system and renders them hypersensitive to tem­perature change and handling (Campbell and Delfosse, 1984). H. perforatum infested 188,000 ha in New South Wales (N.S.W.) in 1976, (Campbell, 1977) and 173,000 ha in Victoria in 1983 (Shepherd, 1983). Specimens of H. perforatum collected in 1929 in N.S.W., Victoria and South Australia were classed as the narrow leaved var. angustifolium De Candolle (Calvert, 1930, 1932) at the Royal Botanic Gardens, Kew (B. Mathew, pers. …

The Potential For Pasture Seed Production In Yunnan Province, Southern China, Li Shuan

IGC Proceedings (1977-2023)

The objective of the seed production team has been to develop commercial seed production capabilities in the Yunnan Livestock and Pasture Development Project areas in Yunnan (Vaughan, 1987). It is mainly a mountainous area with altitudes ranging from 86 min the SE to 6,580 m in the NW. Since 1983, 523 cultivars or breeding materials of many trop­ical, transitional and temperate species have been introduced for evaluation at 13 sites in different ecological zones. About 90 cultivars show good adaption and produce high yields of dry matter.

A Comparison Of Rhizome And Seed Propagation Of Three Grasses Of Nei Mongol: Chinese Wildrye, Tender Pennisteum And Reedlike Foxtail, Na Sen, Lee Yan Qin, Su Xiao Lin

IGC Proceedings (1977-2023)

China is making great efforts to re-vegetate and improve her rangelands. In Inner Mongolia, improvement and expansion of the rangeland base is necessary to meet the needs of a flourish­ing local livestock industry, and growing demand for livestock products (including draft animals) in China as a whole. But the harsh growing conditions in this cold, dry and windy steppe country make seedling establishment difficult, and propagation with seed is risky at best. Methods of grassland propagation that minimize this risk, reduce the rest period after planting, and result in a more productive range will aid the revegetation effort considerably, and …

Modification Of Stolon Growth, Development And Flowering By Plant Growth Regulators In White Clover (Trifolium Repens L.) Seed Crops, A H. Marshall, D H. Hides

IGC Proceedings (1977-2023)

Within the EEC the need to develop low cost less intensive systems of animal production has led to an increase in the importance of legumes generally, and white clover in particu­lar. At present, annual white clover seed usage within the EEC is approximately 4,000 tonnes, however, the self sufficiency rate is expected to fall below 50 % by the end of the 1980s due prin­cipally to unpredictable seed yields which make it an unprofit­able crop for seed growers. The main component of seed yield in white clover is the number of ripe inflorescences at harvest (Zaleski, 1961) however, the proportion …

Plant Resources And Forage Seed Production In China, Dong Peihua

IGC Proceedings (1977-2023)

China is situated in the Eastern part of Asia ; from North to South it extends across the temperate and tropical zones. From East to West it has humid, semiarid, arid regions. There is no frost through the year in some part ofHainan Island, Yunnan, Guangdong and Taiwan provinces. Therefore plants grow the year round and there is a wide range of tropical species. The geographical and climatical differences resulted in rich grass resources. There are three hundred million hectares of natural pastures in Northern China, with more than 4000 plant species. These plants have different degrees of feeding value. …

Goat Tying Styles Impact On Performance Consistency With Rodeo Competitors In The National Intercollegiate Rodeo Association Ozark Region, Marie Baxley, C.A. Shea Porr, Thomas Powell

Honors College Theses

Goat tying is a rodeo event involving dismounting a horse, and flanking and tying three legs of a goat. Flanking is defined as picking a goat up and setting it on the ground on its side. Flank/gather (FG) is a style where riders scoop the legs with the right hand and then place them in the left. Catch the flank (CF), stuffing (ST), and funneling (FN) are other methods that involve the goats’ legs landing together so the right hand is not needed for gathering. The objectives of this study were to determine 1) if flanking method affects performance, and …

Reflexology For Chronic Pain, Ana M. Scheiber

Theses and Graduate Projects

Abstract

Background: Millions of Americans are diagnosed and suffer with chronic pain everyday. Patients with chronic pain typically require frequent and routine healthcare visits to manage many symptoms. This scholarly project evaluated individuals who lack health care accessibility and are currently homeless individuals with chronic pain. Methods: The scholarly project was conducted over three weeks with twenty consistent participants participating in reflexology sessions for their chronic pain. Supportive studies conducted in Greece, Iran, London, United States were included in the synthesis of evidence-based practice about chronic pain and reflexology. The search methods used in this literature review were through CINAHL …

Daily Acute Intermittent Hypoxia Elicits Age & Sex-Dependent Changes In Molecules Regulating Phrenic Motor Plasticity, Jayakrishnan Nair, Alexandria Marciante, Carter Lurk, Mia Kelly, Maclain Capron, Gordon Mitchell

Department of Physical Therapy Faculty Papers

Acute intermittent hypoxia (AIH) elicits a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). Exposure to repetitive daily AIH (dAIH) enhances pLTF, a form of metaplasticity. Little is known concerning cellular mechanisms giving rise to dAIH-induced metaplasticity and the age-dependent sexual dimorphism of AIH associated pro-plasticity mRNA expression. To test if age, sex, and dAIH effects are associated with differential expression of molecules that regulate the Q- and S-pathways and their cross-talk interactions to phrenic motor facilitation, we analyzed key regulatory molecules in ventral spinal (C3-C5) homogenates from young (3-month) and middle-aged (12-month) male and female Sprague-Dawley …

Laboratory Corporation Of America Holdings V. Davis: Brief Of Civil Procedure And Complex Litigation Law Professors As Amici Curiae In Support Of Respondents, Maureen Carroll

Appellate Briefs

Amici are law professors with expertise in the Federal Rules of Civil Procedure, including the requirements for class certification under Rule 23(b)(3). Together, we share an interest in ensuring that the Federal Rules of Civil Procedure are construed “to secure the just, speedy and inexpensive determination of every action and proceeding.” Fed. R. Civ. P. 1.