Digital Commons Network^™

Molecular Mechanisms Governing Osteosarcoma Pulmonary Metastasis, Niveditha Nerlakanti

USF Tampa Graduate Theses and Dissertations

Osteosarcoma (OS) is a bone cancer that commonly metastasizes to the lung. Despite advances in the development of targeted therapies for treating solid malignancies, broad-acting chemotherapies remain the first line of treatment for OS. In assaying the efficacy of approved therapeutics for non-OS malignancies, we identified the histone deacetylase 1 and 2 (HDAC1 and 2) inhibitor, romidepsin, as effective for treating established lung metastatic OS. However, romidepsin has noted toxicities in humans, thus we aimed to define the primary mechanisms through which HDAC1/2 mediates OS progression to identify more selective druggable targets/pathways. Microarray and proteomic analyses of romidepsin-treated OS cells …

Leveraging The T2t Assembly To Resolve Rare And Pathogenic Inversions In Reference Genome Gaps, Kristine Bilgrav Saether, Jesper Eisfeldt, Jesse D Bengtsson, Ming Yin Lun, Christopher M Grochowski, Medhat Mahmoud, Hsiao-Tuan Chao, Jill A Rosenfeld, Pengfei Liu, Marlene Ek, Jakob Schuy, Adam Ameur, Hongzheng Dai, Undiagnosed Diseases Network, James Paul Hwang, Fritz J Sedlazeck, Weimin Bi, Ronit Marom, Josephine Wincent, Ann Nordgren, Claudia M B Carvalho, Anna Lindstrand

Faculty, Staff and Students Publications

Chromosomal inversions (INVs) are particularly challenging to detect due to their copy-number neutral state and association with repetitive regions. Inversions represent about 1/20 of all balanced structural chromosome aberrations and can lead to disease by gene disruption or altering regulatory regions of dosage-sensitive genes in cis. Short-read genome sequencing (srGS) can only resolve ∼70% of cytogenetically visible inversions referred to clinical diagnostic laboratories, likely due to breakpoints in repetitive regions. Here, we study 12 inversions by long-read genome sequencing (lrGS) (n = 9) or srGS (n = 3) and resolve nine of them. In four cases, the …

Photo Composition Guidance Based On Scene And Subject Analysis, Kshitij Suresh Gaikar, Pushkar Mittal

Defensive Publications Series

This disclosure describes techniques to guide a user in the composition of photos captured by a camera device, based on automatic scene analysis and subject framing. A camera device prompts the user to pan the device across a scene surrounding the user to capture a scene photo, e.g., a 360-degree panoramic photo. Additionally, the user captures a subject photo showing an intended subject for a new photo. An artificial intelligence (AI) model is used to analyze the scene photo and the subject photo. The model outputs locations and/or poses for the subject in the scene that makes for an appealing …

What Is In Your Drink? How Ingredient Lists For Alcoholic Beverages Would Protect Persons With Food Allergies, Benjamin Leraris

DePaul Law Review

No abstract provided.

Table Of Contents

DePaul Law Review

No abstract provided.

The Audacity Of My Father, Mark Oroceo

Night Flight: Online Literary Journal

A coming-of-age story of an immigrant boy, and the story of a fateful night when he was taught the harsh lesson of life consequences. His story touches on his relationship with his absent father, uncaring stepmother, and a reflection of his known emotional trauma all collide in a second story room of his parent's house.

The Misbegotten Mycelium, Cameron Bolen

Night Flight: Online Literary Journal

Below is a creative writing assignment which was my final for one of my courses in Creative Writing. My name is Cameron Bolen and I’ve been going to Embry Riddle Aeronautical University for closing on 6 or 7 years now, on the last few classes before I finish my bachelor’s degree in Homeland Security. I’ve always been a big fan of different fantasy stories like Lord of the rings by J.R.R Tolkien, The Wheel of Time by Robert Jordan, and roleplaying games like Dungeons and Dragons. So, without further Ado, my fantasy tale of The Misbegotten Mycelium, a simple Ode …

Gmc-157 Text-To-Digital Person Video Generator: Digitalavatargen, Akansha Kesharwani, Nisha Bagdwal, Md E Hossain, Drashti Patel, Nikhil Adigoppula

C-Day Computing Showcase

The Text-to-digital person video generator: DigitalAvatarGen project uses AI to create lifelike videos of 2D digital avatars from user text input. Users enter text, select a voice and select or upload an avatar, and generate a video using DigitalAvatarGen web application which uses Google TTS and SadTalker, to synchronize voice, expressions, and lip movements. Key contributions include a customizable user interface, personalized voice and avatar options, and an optimized backend for efficient video generation. This tool provides an engaging, realistic solution for applications in education, media, and customer interaction.

Uc-129 Angel Among Us Pet Rescue - Website Enhancement With Chatbot, Koen Victorica, John Huffstutler, Chaz Dooley, Elizabeth A Kovaltchouk

C-Day Computing Showcase

This project integrates an AI-powered chatbot into the Angels Among Us Pet Rescue website, enhancing user experience by efficiently addressing common queries. The chatbot uses large language model (LLM) technology, which in this project is ChatGPT, to understand and respond to user questions dynamically. A content management system (CMS) supports easy updates to the chatbot’s responses, allowing Angels Among Us staff to manage FAQ entries without technical intervention. The chatbot integrates seamlessly with the existing website, maintaining the organization’s aesthetic, accessibility, and compatibility across devices. This enhancement improves user engagement and streamlines support, enabling the nonprofit to focus more on …

Uc-182 Designing A User-Centered Mobile Application For Anderson Power Services, Ryan Guzman, Cooper Goswick, Anthony Phan, Marie Fotso, Larnel Francois

C-Day Computing Showcase

This paper presents the design and development process of a mobile application for Anderson Power Services, emphasizing both frontend and backend aspects as well as their design. The frontend focuses on creating a visually appealing and user-friendly interface by utilizing clear text, an accessible color scheme, appropriate logos, animations, and modern typography. On the development side, the app leverages tools like Expo for rapid front-end development and integrates the Java-based backend with the Google Sheets API for easy data management. The backend architecture incorporates OAuth 2.0 for secure authentication, Gradle to facilitate a connection between the JavaScript frontend to the …

Gmc-218 Pet Rescue Ai-Based Support Application, Mariah Akintayo, Sibgha Ajmal, Kazi Nafis Ishtiaque, Krut Patel, Chelsi Alexander

C-Day Computing Showcase

This project focuses on the development of an AI-driven support application for foster caregivers at Angels Among Us Pet Rescue. The application provides foster caregivers with real time assistance through an interactive chatbot, task reminders and resource management capabilities, streamlining the caregiving process. By leveraging automation and AI, the application enhances both the foster experience and operational efficiency aligning with the organizations mission of improving animal care.

Uc-134 Volunteer Management System For Angels Among Us, Prince Duepa, Teodora Stoyanova, Radoslav Stoyanov, Madison W Jones, Rodrigo X Caballero

C-Day Computing Showcase

This project focused on creating a Volunteer Management System (VMS) for Angels Among Us (AAU) - a non-profit organization dedicated to rescuing and rehabilitating stray and abandoned animals. This application was developed to: * Handle comprehensive volunteer information * Streamline operations and better manage volunteer data * Support AAU specific use cases * Include a data enrichment capability through a newly developed GUI * Allow authorized users to add more comprehensive information to each volunteer record * implement reporting throughout the data migration process

Uc-201 Halo: A Volunteer Management Application, Carson G Shattuck, Willie D Carder, Russell E Steele, Jeremiah Wisdom, Zeshan Khan

C-Day Computing Showcase

Halo is a comprehensive volunteer management application (VMA) developed to address specific needs identified by Angels Among Us Pet Rescue (AAU). AAU's current system is unable to effectively manage and store complex volunteer information. As the organization’s needs evolved, AAU required a more efficient and secure solution to handle volunteer information. Our team designed Halo using the React.js framework for the frontend, the python based FastAPI framework for the backend, and a PostgreSQL database schema, with Docker containerization to ensure consistent deployment across environments. This setup enables efficient management of volunteer and team data, along with support for exporting reports …

Rifles And Rivals: A Study Of The Domestic Effects On American Military Policy, Rachel Warren

The Dialogue

Rachel Warren analyzes the domestic forces shaping U.S. military foreign policy in the post-Cold War era. The paper evaluates the roles of political polarization and the military-industrial complex, using quantitative analysis to assess their influence on legislative decisions​

Contributors

Antipodes

No abstract provided.

The Buffalo Culture Of The Plains Indians

North Texas Archeological Society Records

A report on the culture of the Plains Indians.

Don’T Trust The Ethicist! Three Theses On The Function Of Ethics In Contemporary Society, Lukas Kaelin

Budhi: A Journal of Ideas and Culture

Don’t Trust the Ethicist! Three Theses on the Function of Ethics in Contemporary Society

Buddha-Nature And Personality As The Ground Of Ethics: A Metaethical Dialogue Between DōGen And Berdyaev, Anton Luis Sevilla

Budhi: A Journal of Ideas and Culture

This paper seeks to contribute to the ongoing Buddhist-Christian dialogue by bringing together the teachings of Zen Master Dōgen and the Russian Christian philosopher Nikolai Berdyaev. This dialogue discusses a metaethical question: What is the foundation of ethical practice? I aim to show that Dōgen’s idea of “buddha-nature” and Berdyaev’s idea of “personality” can be understood as the foundations of ethical practice in ways that are similar and mutually clarifying in their total affirmation of human temporal existence. We begin by discussing the general contours of Dōgen’s practice-realization and Berdyaev’s creative ethics, and then proceed to a comparative examination of …

Spartan Daily, November 19, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 163, Issue 36

Revisiting Charles Perrault’S Iconic “Bluebeard” Serial Killer In Modern French Variants, Christa Catherine Jones

World Languages and Cultures Faculty Publications

“Bluebeard” (ATU 321: Maiden-Killer), a fairy tale about a wealthy noble man and serial killer, is the most gruesome of Charles Perrault’s fairy tales. Bluebeard epitomizes evil and horror. In Perrault’s tale, Bluebeard’s evilness is linked to patriarchy and power, as symbolized by the villain’s iconic blue beard. Historically linked to Henry VIII (1491–1547), King of England, Bluebeard has also been associated with Breton commander Gilles de Rais who was hanged for sorcery and satanic abuse. This article examines how contemporary francophone “Bluebeard” variants refashion and redefine evil and whether they contain any new morals linked to evilness. Do …

Davinci, The Ai Tutor Developed By Lindenwood Student And Faculty, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Joint Senate Meeting Minutes 11-19-24, Unk Student Government

Joint Senate Meeting Minutes

No abstract provided.

Compositions And Methods Relating To Novel Sulfono-Gamma-Aa Peptides, Chuanhai Cao, Jianfeng Cai

USF Patents

Provided herein are compounds, compositions, pharmaceutical compositions, kits, and methods relating to novel sulfono-γ-AA peptides. Novel sulfono-γ-AA peptides as described herein can have the structure according to Formula 1: In embodiments according to the present disclosure, novel sulfono-γ-AA peptides as described herein have minimal toxicity, can repair neuronal damage, inhibit Amyloid beta aggregation, and promote cellular growth and viability.

Systems And Methods For Classifying Mosquitoes Based On Extracted Masks Of Anatomical Components From Images, Sriram Chellappan, Mona Minakshi, Pratool Bharti, Ryan M Carney

USF Patents

Images of an insect are subjected to at least a first convolutional neural network to develop feature maps based on anatomical pixels at corresponding image locations in the respective feature maps. The anatomical pixels correspond to a body part of the insect. A computer calculates an outer product of the first feature map and the second feature map to form an integrated feature map. Extracting fully connected layers from respective sets of integrated feature maps and applying the fully connected layers to a classification network for identifying the genus and the species of the insect.

Methods For Sampling Into An Atmospheric Pressure Inlet Mass Spectrometer, Theresa Evans-Nguyen, Linxia Song, Yi You

USF Patents

Provided herein are systems and methods for sampling analytes into an atmospheric pressure inlet mass spectrometer using ultrasonic nebulization-assisted atmospheric pressure chemical ionization. The systems can include a mass spectrometer having an input and an ultrasonic nebulizer chip. The ultrasonic nebulizer chip can be operatively coupled to the mass spectrometer, such that when the ultrasonic nebulizer chip nebulizes the analyte to provide a nebulized analyte, at least some of the nebulized analyte enters the input of the mass spectrometer.

Plasma Derived From Human Umbilical Cord Blood For The Treatment Of Neurodegenerative Disorders, Svitlana Garbuzova-Davis, Jared Carl Ehrhart, Paul R. Sanberg

USF Patents

A method of treating neurodegenerative diseases using hUCB plasma is presented herein. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the non-responders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggest that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. hUCB plasma …

Il-37 Suppresses Cns Autoimmunity By Increasing The Frequency Of Treg Cells And Reducing Cd4 + T Cell-Derived Il-10 Production, Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam-Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Mohamad Rostami

Department of Neurology Faculty Papers

BACKGROUND: Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels of IL-37. However, it is unknown whether IL-37 has an inhibitory effect on ongoing autoimmune neuroinflammation, thus offering a potential MS therapy.

AIM: Here, we examined the effect of IL-37 in an experimental autoimmune encephalomyelitis (EAE) model after disease onset to determine if it was protective.

FINDINGS: IL-37-treated mice developed a less severe disease than control mice, with reduced demyelination as determined by increased expression of myelin basic protein. …

Cas Connections- 2024 Fall Term - November, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.

Mediator Kinase Inhibitors Suppress Triple-Negative Breast Cancer Growth And Extend Tumor Suppression By Mtor And Akt Inhibitors, Xiaokai Ding, Jiaxin Liang, Amanda C. Sharko, Thomas A. Hilimire, Jing Li, Jürgen Loskutov, Zachary T. Mack, Hao Ji, Gary P. Schools, Chao Cai, Elena N. Pugacheva, Mengqian Chen, Igor Roninson, Eugenia Broude

Faculty Publications

Triple-negative breast cancers (TNBC) are treated primarily by chemotherapy and lack clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR pathway, abnormally activated in many breast cancers, failed to achieve clinical efficacy in TNBC due to the development of adaptive drug resistance, which is largely driven by the transcriptomic plasticity of TNBC. Expression of CDK8/19 Mediator kinases that control transcriptional reprogramming correlates with relapse-free survival and treatment failure in breast cancer patients, including TNBC. We now investigated how CDK8/19 inhibitors affect the growth of TNBC tumors and their response to mTOR and AKT inhibitors. In contrast to the effects …

A Systematic Exploration Of Theoretical, Conceptual, And Methodological Alignment Of Social Network Analysis In Organizational Behavior, Morgan Gleason Miller

College of Science and Health Theses and Dissertations

This systematic review examines how Social Network Analysis (SNA) is used in the study of Organizational Behavior (OB). Industrial-Organizational Psychology Literature suggests SNA tends to be applied using either a structural or relational approach (Erikson, 2013). Some researchers claim that this methodology is applied inconsistently due to the intermingling of two distinct underlying frameworks and the exclusion of individual differences and interpersonal factors limits the relevance of SNA (Erikson, 2013; Kilduff & Lee, 2020). Results indicate the structural perspective is slightly dominant across the use of SNA, but the use of both frameworks is increasing. Directionally, study methods aligned with …