Digital Commons Network^™

Does Probiotic Supplementation Help Decrease Symptoms In Adults Previously Diagnosed With Major Depressive Disorder?, Alexa Hammock, Hayley Loiselle

Physician Assistant Capstones, 2020-current

Objective: To assess the effect of probiotic supplementation on clinical symptoms of major depressive disorder in adults. Design: Systematic literature review. Methods: Searches were performed on PubMed using the terms “adults with depression and probiotics”. The limits on PubMed were set to include randomized control trials, studies on adults, studies done within the last 10 years, studies done on patients that did not have depression, studies that did not use the Beck Depression Inventory, and studies that focused on other conditions. Results: Three studies were found that met search criteria: Reninghaus et al., Schaub et al., and Chahwan et al. …

Is Racial Diversity Important When Applying To Jmu Pa Program?, Gaelyn E Young, Deonte J. Hope

Physician Assistant Capstones, 2020-current

The Physician Assistant profession is predominantly female and Caucasian. In order to increase the diversity of the profession at the level of the workforce, it is necessary to examine PA programs' role as the entryway into the profession. To that end, this evaluation aimed at surveying current and future PA students at James Madison University to understand whether racial diversity of both the program's cohort and/or its faculty was a factor in their decision to apply and/or attend the school.

Focused Assessment With Sonography Exams Vs Ct Scan, Anne Kresge, Charlotte Mueller, Briar Tures

Physician Assistant Capstones, 2020-current

Blunt trauma is a common reason patients present to the emergency department. Providers must evaluate these patients quickly to get them the correct treatment, especially for intra-abdominal bleeding. Focused assessment with sonography for trauma (FAST) exams are growing in use to evaluate trauma patients for free fluid in the abdomen. To be valuable to emergency providers, it must be known how FAST exams compare to the gold standard evaluation, computed tomography (CT) scans. Searches were done on Pubmed and Scopus databases using terms “focused assessment with sonography for trauma” and “FAST exam CT blunt abdominal trauma.” Limits were added to …

Congratulations, Library Graduates, University Of Dayton

University Libraries Blog Archive

The University Libraries rely on student employees to help meet the University’s research, teaching and learning needs. The faculty and staff in the University Libraries honor, thank and congratulate the student staff listed below, who graduate this week.

The Brief (Edition #31, December 2023), William & Mary Law School

The Brief

No abstract provided.

An Analysis Of The Nickel Boys: Deviance In The Jim Crow South, Amani Moses

The Crown: Syracuse Honors Research Journal

No abstract provided.

Feasibility And Measurement Of Bedside Pumping In The Nicu: A Mixed Methods Study, Jessica Gomez

Dissertations and Theses (Open Access)

Abstract

Background: Supporting preterm infants with mother’s own milk (MOM) can improve health outcomes and decrease mortality.¹ Freshly pumped MOM, within four hours of expression, has the highest availability of bioactive components versus stored MOM. However, fresh milk is often not readily available due to the disconnected process of breastfeeding that occurs with preterm infants in the NICU. One convenient solution to improve access to fresh MOM is for the mother to pump at the infant's bedside. This intervention could improve the mother's pumping experience and provide the infant access to fresh MOM.

Purpose: This study aimed to evaluate …

Lifestyle Behaviors Before And After Diagnosis Of Type 2 Diabetes: Findings From The Nurses’ Health Studies, Amelia E. Roebuck

Dissertations and Theses (Open Access)

Short- and long-term changes in diet or physical activity in relation to type 2 diabetes mellitus (T2DM) and factors associated with behavior change with adequate inclusion of relevant confounding and effect-modifying variables have been minimally explored. The objective of this research was to examine changes in diet and physical activity following a diagnosis of T2DM and identify sociodemographic, medical, psychosocial, and lifestyle factors associated with changes in dietary or physical activity behaviors. This dissertation utilized two prospective cohorts of U.S. female nurses participating in the Nurses’ Health Study (1976-2016) and Nurses’ Health Study II (1989-2017). Linear mixed effects modeling was …

Usp1 Expression Driven By Ews::Fli1 Dually Promotes Ewing Sarcoma Cell Survival By Mitigating The Replication Stress Response And Stabilizing Survivin, Halle Mallard

Theses & Dissertations

Ewing sarcoma (EWS) is a malignant pediatric bone cancer. EWS express a fusion oncogene resulting from the reciprocal translocation of EWSR1 an ETS transcription factor. In most EWS tumors, this occurs with FLI1, creating the EWS::FLI1 fusion oncogene which encodes an aberrant transcription factor. Independent of its transcriptional activity, EWS::FLI1 deregulates other cellular processes driving oncogenesis. For cases with a single, localized tumor, roughly 80% of patients remain event-free after five years. Disease dissemination is a problem – about 25% of patients have metastatic disease at diagnosis. Long-term survival for these patients is less than 40%. Presently, no second line …

Paper-Based Ratiometric Sensor Array For Pathogenic Bacterial Species Identification, Aayushi Laliwala

Theses & Dissertations

Bacterial infections are the leading cause of mortality worldwide due to the lack of accurate diagnosis of the pathogens causing infections. Currently, microbiological and molecular techniques are used to identify pathogenic bacteria. However, these techniques have limitations as they are time-consuming, cost-inefficient, and require trained personnel. Therefore, timely and precise identification of pathogenic bacteria is crucial for public safety. Our lab previously synthesized a fluorescent sensor array (3-hydroxyflavone derivatives) encapsulated in hyaluronic acid-based nanoparticles to identify bacterial species and recognize their Gram status. Though promising, this technique was relatively time-consuming and required high sample and volumes.

To overcome these limitations, …

Cardiac Vagal Dysfunction And Ventricular Arrhythmogenesis In Type 2 Diabetes Mellitus After Myocardial Infarction, Dongze Zhang

Theses & Dissertations

Diabetes is the eighth leading cause of death in the United States. Every eight seconds a person dies from diabetes around the world. Among various types of diabetes, type 2 diabetes mellitus (T2DM) is the most common form, representing 90% to 95% of all diabetes populations. The leading cause of mortality and morbidity in T2DM patients is cardiovascular disease, among which acute myocardial infarction (MI)-induced ventricular arrhythmia is the major cause of death in T2DM. Patients with T2DM are two to four times more likely to die from MI than non-diabetic patients. Although well-known therapies including better glycemic control have …

Targeting Metabolic Switches And Dna Damage Repair For The Treatment Of Human Diseases, Rasangi Chathurika Kankanam Pathirage

Theses & Dissertations

Tuberculosis and Cancer treatments share common challenges due to prolonged therapy, the necessity of combination therapy and severe side effects. Characterization of novel drug targets and identification of new drugs modulating such targets within the context of multidrug treatments will contribute to overcoming current therapeutic challenges.

Tuberculosis (TB) is one of the challenging diseases to treat due to the persistence of Mycobacterium tuberculosis (Mtb) in the dormant phase. Current TB drugs are more effective toward actively dividing bacteria and less effective toward dormant bacteria. The metabolic transition between actively dividing bacteria and dormant bacteria is driven by pivotal metabolic enzymes …

Feasibility Of A Laboratory Model For Evaluating The Use Of An Alternative Response Option In Mitigating Caregiver Treatment Integrity Errors, Jessie K. Weber

Theses & Dissertations

The current study assessed the feasibility of a laboratory model designed to evaluate options for mitigating common caregiver errors in the implementation of destructive behavior treatment. We developed a computer-based analogue to caregiver implementation of extinction for attention-maintained destructive behavior; the model included contingencies on both caregiver errors of commission and adherence to the treatment protocol. We also conducted a preliminary investigation of the effects of participant access to alternative activities as a potential strategy for mitigating integrity errors. Participants included 14 MTurk workers or staff in a severe behavior clinic, and individual response patterns revealed distinct sensitivities to the …

The Effect Of Non-Immersive Virtual Reality Radiographic Positioning Simulation On First-Year Radiography Students' Image Evaluation Of Routine Positioning Errors, Ellie M. Miller

Theses & Dissertations

Optimal radiographic image quality is critical because it affects the accuracy of the radiologist’s interpretation. Radiologic technologists are obligated to obtain diagnostic images while minimizing patient radiation. However, repeated images due to technologist error have increased in recent years. This study aimed to evaluate the effectiveness of non-immersive virtual reality (VR) simulation on first-year students’ image evaluation of common positioning errors on routine knee and lumbar spine protocols. Research questions were 1) Does guided instruction using non-immersive radiographic positioning simulation software lead to improved image evaluation scores? 2) How well do participants describe evaluation of positioning errors after guided instruction …

Biomechanics Of The Tip-Back Bend: An Analysis Of The Force System Via Translational Research, Lyndzie Brace

Theses & Dissertations

Purpose: The purpose of this study was to 1. experimentally (in vitro) quantify the force system acting on the molar and the incisor when a tip-back bend is placed on an auxiliary spring mounted on a base archwire and create a prediction model 2. to compare the type of tooth movement obtained from the prediction model (in-vitro) and the clinical outcome (in-vivo) data obtained from a previously conducted clinical trial. Methods: A computerized 3-dimensional (3D) orthodontic force tester (OFT) was used to quantify and compare the force systems generated from different combinations of tip-back bend archwires and base …

Early Diagnosis Methods For Autism Spectrum Disorder: A Systematic Review, Megan Denise Mccarthy

Doctoral Dissertations

Objective: This systematic review aimed to comprehensively synthesize existing literature on early detection methods for Autism Spectrum Disorder (ASD) in children birth to 3 years, that lead to an effective and reliable early diagnosis in children 2 to 3 years of age.

Methods: A systematic search was conducted across multiple electronic databases, including PubMed, Scopus, and PsycINFO following PRISMA guidelines. Studies reporting on early detection methods for ASD in infants and toddlers within ages 0 to 3 years that lead to early diagnosis of children ages 2 to 3 years were eligible for inclusion. Data extraction and quality assessment were …

Celtic Inspired Evangelism: Creation, Women Saints, And Pilgrimate, Laceye Warner

Witness

No abstract provided.

Lemons And Other Grand Delusions, Jake A. Yarnold

Master's Theses

Lemons and Other Grand Delusions explores a host of characters as they come face to face with their greatest fears, as they get exactly what they think they want. From magic dimension-bending lemons, to automatons powered by the Philosopher’s Stone, as the powers from beyond become in-hand realities, the characters find their greatest desires are not as simple and powerful in their hands as they first thought. Exploring the limits of greed and desire within ourselves and in the society we live in, the collection asks who are we, if not a collection of our own desires, and the impulses …

From Margins To Museums: Tracing The Evolution Of Representation For Contemporary African Artists In The United States, Victoria Mouraux Durand-Ruel

Master's Theses

This thesis examines the impact of the Black Lives Matter movement on the art community in the United States and the evolution of representation for Contemporary African artists. By analyzing the careers and artistic contributions of Omar Ba, Toyin Ojih Odutola, and Njideka Akunyili Crosby, the study explores the concept of artistic agency according to which African artists have more control over the production and distribution of their works.

The research begins with a comprehensive literature review, investigating the historical contexts that have shaped the art landscape, including the impact of colonization, decolonization, and globalization. The study reveals how these …

American Institution Of Public, K-12 Education: An Institutional Field Under A Complexity Paradigm, Jennifer Jean Joyalle

Dissertations and Theses

Institutional fields serve as foundational bedrocks that shape and govern behaviors, norms, and practices within distinct domains of societal and organizational interactions. The emergence of machine learning and the ability to manipulate large datasets offer researchers and decision makers the potential ability to model and visualize the behavior associated with institutional fields.

This proof of concept provides an example of visualizing the changing conditions in the institutional field of public K-12 education in America as a topology. By interweaving three primary strands of theory -- institutional fields, complexity in the guise of complex adaptive systems as a paradigm, and paradigms …

Dna Methylation-Based Epigenetic Biomarkers In Cell-Type Deconvolution And Tumor Tissue Of Origin Identification, Ze Zhang

Dartmouth College Ph.D Dissertations

DNA methylation is an epigenetic modification that regulates gene expression and is essential to establishing and preserving cellular identity. Genome-wide DNA methylation arrays provide a standardized and cost-effective approach to measuring DNA methylation. When combined with a cell-type reference library, DNA methylation measures allow the assessment of underlying cell-type proportions in heterogeneous mixtures. This approach, known as DNA methylation deconvolution or methylation cytometry, offers a standardized and cost-effective method for evaluating cell-type proportions. While this approach has succeeded in discerning cell types in various human tissues like blood, brain, tumors, skin, breast, and buccal swabs, the existing methods have major …

Dim111.2 Scholarly Persectives On Design: Analysis Of A Creative Work Example 1, Sae University College

Exemplars

DIm111 Project 2 example of visual analysis essay showing high quality work.

Fabrication And Characterization Of Flexible Microelectrode Arrays On Kapton Polyimide For Implantable Spinal Cord Stimulation Applications, Nabil Jamhour

Theses and Dissertations

Recent advances in spinal cord stimulation (SCS) technology have made a significant impact in the treatment of chronic pain which is a prevalent issue amongst 20% of the population in developed nations. A few medical device manufactures have developed SCS devices that have been studied in clinical environments and reported to be effective and safe for commercial use. However, the current SCS devices available are bulky, rigid, and still present infection, fibrosis, discomfort, pulse delivery challenges and other concerns for patients. In this study, flexible electrodes processed on Kapton® polyimide films by physical vapor and inkjet deposition are fabricated and …

College Student Attitudes Toward Student-Athlete's Ability To Profit From Name, Image, And Likeness (Nil), Daniel G. Panzano

Honors Theses

Since the recent passing of legislation allowing student-athletes to profit from their own personal brands and sponsorships (Name, Image, and Likeness; NIL), there has been very little research. The purpose of this study was to measure the attitudes and support students have towards the financial compensation of their student-athlete counterparts. The researchers surveyed 67 Coastal Carolina University students. Using a quantitative study, data was gathered pertaining to the opinions toward NIL, feelings of team affiliation, and demographic information. Statistically significant differences were found toward some elements of NIL and gender, major, and academic year. A statistically significant correlation was also …

Quality Of Life And Unmet Needs Of Late-Stage And Metastatic Colorectal Cancer Survivors, Krista Brown

Theses & Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in both men and women and is the second leading cause of cancer deaths when men and women are combined. CRC survivors are living longer with an increase in 5-year survival, rising from 52% in the 1980s to 62% in the 2000s. The objective of this dissertation was to explore the QoL and unmet needs of stage III and IV CRC survivors and contribute to the field of survivorship research through an integrative literature review of the state of the science and a sequential, explanatory mixed methods study.

The …

Characterization Of Trafficking And Metabolic Functions Of The Endocytic Regulator Ehd1 In Ewing Sarcoma, Sukanya Chakraborty

Theses & Dissertations

Ewing sarcoma (EWS) is the second most common bone malignancy in children and adolescents. Despite improvement in survival due to advances in multimodality treatment strategies, patients with metastatic or recurrent disease have very poor outcomes. Overexpression of the EPS15 Homology Domain containing 1 (EHD1) protein has been linked to tumorigenesis but whether its core function as a regulator of intracellular traffic of cell surface receptors plays a role in oncogenesis remains unknown.

Studies presented in this dissertation establish that EHD1 overexpression is a feature of nearly 90% EWS patient tumors with high EHD1 expression specifying shorter patient survival. ShRNA-knockdown and …

Three-Dimensional Analysis Of Condylar Displacement After Orthognathic Surgery In Patients With Facial Asymmetry, Teresa Bae

Theses & Dissertations

Facial asymmetry is apparent when there is a clinically significant variation between the two halves of the face. There can be varying degrees of facial asymmetry and mild asymmetry can be treated by orthodontics alone. For severe facial asymmetry a combination of orthodontics and orthognathic surgery may be necessary. The condyle must be in a stable position following surgery to have functional and structural stability and prevent relapse. This research proposal is to perform a retrospective CBCT study on the displacement of the condyle following orthognathic surgery in patients with facial asymmetry. The CBCTs were obtained from Taipei Veterans General …

The Impact Of Covid-19 On The Financial Health And The Stock Market Valuation Of The Wig.Games5 Companies, Kamil Głowa

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The article aims to assess the impact of the COVID-19 pandemic on the companies included in the WIG.GAMES5 index that is listed on the Warsaw Stock Exchange, for the period 2019–2021. Design/Methodology/Approach: In order to conduct the study quarterly and annual financial statements were used. The financial condition was examined by ratio analysis, while the valuation was carried out using financial multipliers’ analysis. Findings: The results of the ratio analysis led to the conclusion that COVID-19 and the restrictions associated with it had a positive impact on the financial health of the companies included in the WIG.GAMES5 index, inter …

Students’ Perception Of Possibilities Of Using Business Process Modeling To Improve Organizations, Małgorzata Oleś-Filiks

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The main aim of this article is to analyze the knowledge of the students – future users of these systems – of the awareness of the use and possibilities of using business process modeling in improving the organization. Design/Methodology/Approach: The research was carried out using the CAWI method. The questionnaire prepared for this purpose was first verified with the participation of experts in the field of business process modeling and then made available to students to fill in on the servers of the Faculty of Management of the University of Warsaw. The study concerned general knowledge of concepts related …

Internet Generations In The Labor Market, Grażyna Wieczorkowska, Kinga Wilczyńska

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Objectives: When describing generational differences, the concept of a collective (prototypical) unit is used, which has been shaped by prevalent social and cultural conditions during the formative period of secondary socialization. Generations whose privileged period coincided with the widespread use of the internet have been referred to as internet generations. The article aims to draw attention to the need to separate the effects of biological age (younger doroworkers differ from older ones in terms of factors such as muscle strength and fresh memory) from the effects of generation resulting from environmental differences during the privileged period of secondary socialization. Methodology: …