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2023

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Cslinc: A Nationwide Cs Mooc For Second-Level Students, Karen Nolan, Keith Quille, Brett A. Becker Jan 2023

Cslinc: A Nationwide Cs Mooc For Second-Level Students, Karen Nolan, Keith Quille, Brett A. Becker

Academic Posters Collection

This poster introduces CSLINC, a free scaffolded MOOC framework tailored to second-level students in Ireland that consists of: an online platform built for accessibility; a suite of modules developed upon international best practices with varying co-creators; and automated assessment and certificates of completion. Its aim is to provide content to promote national CS curricula to all second-level students in Ireland. In September 2021, CSLINC launched to 10,000 students across 100 schools. Future work will include collecting and collating research to validate CSLINC’s goals, scaffolding that will build foundations for national curriculum learning outcomes, and measure its impact on students, their …


Attention-Based Gender-Stereotype Detection, Manuela Nayantara, Sarah Jane Delany Jan 2023

Attention-Based Gender-Stereotype Detection, Manuela Nayantara, Sarah Jane Delany

Academic Posters Collection

Gender stereotypes are perceptions about the typical physical, emotional, and social characteristics of individuals. Unlike gender bias which can result in the systematic and unfair treatment of individuals based on their gender, gender stereotypes do not always perpetuate a negative impact. Hence, there is no solid definition that frames what is considered a gender-stereotype in text. In addition, there is also a lack of labelled gender-stereotype datasets. This has led to most of the work in literature being about gender bias and not gender stereotypes. Therefore, in our research, we frame a clear definition of what constitutes a gender-stereotype in …


From Overlay To Interplay - Subverting The Message And Creating The Surreal With Augmented Reality, Nina Lyons Jan 2023

From Overlay To Interplay - Subverting The Message And Creating The Surreal With Augmented Reality, Nina Lyons

Academic Posters Collection

This proof of concept utilises content creation tools that create diegetic presentation which is not commonly utilised in AR systems. In this study, the virtual overlay that becomes visible through AR displays diegetic content that disrupts the meaning of the poster highlighting the potential for AR as a visual communication medium and the opportunities that AR has, as a medium, for creating narrative.


Spoken Language To Irish Sign Language Machine Translation: A Linguistically Informed Approach, Jesus Aguilar Lopez, Irene Murtagh, Sheila Castilho Jan 2023

Spoken Language To Irish Sign Language Machine Translation: A Linguistically Informed Approach, Jesus Aguilar Lopez, Irene Murtagh, Sheila Castilho

Academic Posters Collection

Many deaf and hard-of-hearing individuals rely on sign language (SL) on a daily basis as a preferred language. Although nowadays there are significant advances on spoken language research, current approaches are often neither linguistically motivated nor tailored to the unique features of SLs. Further research and development are necessary to enhance Sign Language Machine Translation (SLMT) and bring it to a similar level as spoken language MT. This research will endeavour to improve the accuracy and efficiency of SLMT systems, making them more accessible to the Deaf community and empowering deaf and hard of hearing individuals to communicate more effectively …


A Framework For Confusion Mitigation In Task-Oriented Interactions, Na Li, Robert J. Ross Jan 2023

A Framework For Confusion Mitigation In Task-Oriented Interactions, Na Li, Robert J. Ross

Academic Posters Collection

Confusion is a mental state that can be triggered in task-oriented interactions and which can if left unattended lead to boredom, frustration, or disengagement from the task at hand. Previous work has demonstrated that confusion can be detected in situated human-robot interactions from visual and auditory cues. Therefore, in the next step, we propose appropriate interaction structures in this study, which should be used to mitigate confusion. We motivate and describe this dialogue mechanism through an information state-style dialogue framework and policies, and also outline the approach we are taking to integrate such a meta-conversational goal alongside core task-oriented considerations …


Dataset For Gendered Language, Shweta Soundararajan Jan 2023

Dataset For Gendered Language, Shweta Soundararajan

Datasets

Gendered language is the use of words that denote an individual’s gender. This can be explicit where the gender is evident in the actual word used, e.g. mother, she, man, but it can also be implicit where social roles or behaviours can signal an individual’s gender - for example, expectations that women display communal traits (e.g., affectionate, caring, gentle) and men display agentic traits (e.g., assertive, competitive, decisive). The use of gendered language in NLP systems can perpetuate gender stereotypes and bias. This paper proposes an approach to generating gendered language datasets using ChatGPT which will provide data for data-driven …


The European Commission And Ai: Guidelines, Acts And Plans Impacting The Teaching Of Ai And Teaching With Ai, Keith Quille, Brett A. Becker, Lidia Vidal-Meliá Jan 2023

The European Commission And Ai: Guidelines, Acts And Plans Impacting The Teaching Of Ai And Teaching With Ai, Keith Quille, Brett A. Becker, Lidia Vidal-Meliá

Academic Posters Collection

Recent developments, guidelines, and acts by the European Commission have started to frame policy for AI and related areas such as ML and data, not only for the broader community, but in the context of education specifically. This poster presents a succinct overview of these developments. Specifically, we look to bring together all publications that might impact the teaching of AI (for example, teacher expectations in the coming years around AI competencies) and publications that affect the use of AI in the classroom. We mean using tools and systems that incorporate both ‘Good Old Fashioned’ AI and those that can …


Co-Design Of An Interactive Wellness Park: Exploring Design Requirements For A Multimodal Outdoor Physical Web Installation With Older Adults, Fatima Badmos Jan 2023

Co-Design Of An Interactive Wellness Park: Exploring Design Requirements For A Multimodal Outdoor Physical Web Installation With Older Adults, Fatima Badmos

Academic Posters Collection

The global demographic landscape is experiencing a notable shift, characterised by a growing proportion of adults over 60. According to projections, the proportion of individuals aged 60 and above is expected to reach one-sixth of the global population by 2030. Furthermore, by 2050, this demographic is projected to exceed a staggering two billion people. Amidst this shift, there is an urgent need to develop interactive and innovative solutions to address older adults' unique challenges, particularly in outdoor physical activity.

A co-design methodology involving older adults’ participation from the idea generation to the application development process will be adopted to address …


Techmate: A Research-Driven Toolkit To Enhance Gender Balance In Computing Education, Alina Berry, Sarah Jane Delany Jan 2023

Techmate: A Research-Driven Toolkit To Enhance Gender Balance In Computing Education, Alina Berry, Sarah Jane Delany

Academic Posters Collection

This poster presents a toolkit of practical initiatives and guidance on how to enhance gender balance in computing higher education. The suggested initiatives are designed in the way that could be adapted for a use in a local context, especially in universities in the UK or in Ireland. The initiatives are categorised under four main areas: Policy, Pedagogy, Influence & Support and Promotion & Engagement. Additionally, guidance is given on mechanisms to evaluate the impact of these initiatives. This work will be of interest to champions looking to enhance gender balance in their computing courses.


They Followed The Cheese - Visual Web-Based Experiments Showcasing The Opportunities Available For The Presentation Of Information In Ar, Nina Lyons Jan 2023

They Followed The Cheese - Visual Web-Based Experiments Showcasing The Opportunities Available For The Presentation Of Information In Ar, Nina Lyons

Academic Posters Collection

The desktop paradigm bridged a sizeable usability gap at a time before the term “usability” became a conscious objective goal of developers. Mapping the capabilities of the computer to how a user understands their work desk, helped users understand how to interact with a computer. The paradigm has evolved and continues to evolve and reshape itself in different platforms. However, the UIs still rely heavily on established laws and principles that suit the conditions of screens. AR has the opportunity to leverage Semiotic Extension to create context relevant UIs that rely on the focus of the real-time view to inform …


Enhancing Early-Stage Xai Projects Through Designer-Led Visual Ideation Of Ai Concepts, Helen Sheridan, Emma Murphy, Dympna O'Sullivan Jan 2023

Enhancing Early-Stage Xai Projects Through Designer-Led Visual Ideation Of Ai Concepts, Helen Sheridan, Emma Murphy, Dympna O'Sullivan

Academic Posters Collection

The pervasive use of artificial intelligence (AI) in processing users’ data is well documented with the use of AI believed to profoundly change users’ way of life in the near future. However, there still exists a sense of mistrust among users who engage with AI systems some of this stemming from lack of transparency, including users failing to understand what AI is, what it can do and its impact on society. From this, the emerging discipline of explainable artificial intelligence (XAI) has emerged, a method of designing and developing AI where a systems decisions, processes and outputs are explained and …


Unlocking The Black Box: Evaluating Xai Through A Mixed Methods Approach Combining Quantitative Standardised Scales And Qualitative Techniques, Helen Sheridan, Dympna O'Sullivan, Emma Murphy Jan 2023

Unlocking The Black Box: Evaluating Xai Through A Mixed Methods Approach Combining Quantitative Standardised Scales And Qualitative Techniques, Helen Sheridan, Dympna O'Sullivan, Emma Murphy

Academic Posters Collection

In 1950 when Alan Turing first published his groundbreaking paper, computing machinery and intelligence and asked “Can machines think?” a new era of research exploring the intelligence of digital computers and their ability to deceive and/or imitate a human was ignited. From these first explorations of AI to modern day artificial intelligence and machine learning systems many advances, breakthroughs and improved algorithms have been developed usually advancing at an exponential pace. This has resulted in the pervasive use of AI systems in the processing of data. Concerns have been expressed related to biased decisions by AI systems around the processing …


New Triassic Finding In Andız Peninsula (İzmir, Western Turkey) And Comparison Of Pre-Neogene Sequences Of Andız And Karaburun Peninsulas: Stratigraphic And Tectonic Implications, İsmai̇l İşi̇ntek Jan 2023

New Triassic Finding In Andız Peninsula (İzmir, Western Turkey) And Comparison Of Pre-Neogene Sequences Of Andız And Karaburun Peninsulas: Stratigraphic And Tectonic Implications, İsmai̇l İşi̇ntek

Turkish Journal of Earth Sciences

This study aims to review the geology of the Andız Peninsula and compare the pre-Neogene Andız succession with the middle part of the Karaburun Peninsula to discuss the nature of the Paleozoic-Mesozoic boundary in the Karaburun Peninsula. The pre-Neogene units of the Andız Peninsula are represented by the Paleozoic Dikendağı, Triassic Gu?vercinlik, and Jurassic Nohutalan Formations. In this study, the Triassic carbonate rocks in the Andız Peninsula are paleontologically defined for the first time. The Megalodont-bearing Gu?vercinlik Formation contains a late Norian-Rhaetian characteristic foraminiferal assemblage consisting of Aulotortus gr. sinuosus, A. tenuis, A. friedli, A. impressus, and Triasina hantkeni. The …


Foraminiferal Micropaleontology Of The Harami Formation (Elazığ, Eastern Turkey), And Reassessment Of Its Age Based On Larger Benthic Foraminifera, Si̇bel Kayğili Jan 2023

Foraminiferal Micropaleontology Of The Harami Formation (Elazığ, Eastern Turkey), And Reassessment Of Its Age Based On Larger Benthic Foraminifera, Si̇bel Kayğili

Turkish Journal of Earth Sciences

The age and depositional environment of the Harami Formation were reevaluated based on the new larger benthic foraminiferal (LBF) data. LBF assemblage including Orbitoides medius (d'Archiac), O. megaloformis Papp and Küpper, O. gruenbachensis Papp, Pseudomphalocyclus blumenthali Meriç, Omphalocyclus macroporus (Lamarck), Sirtina cf. orbitoidiformis Brönnimann and Wirz, Hellenocyclina beotica Reichel, Lepidorbitoides campaniensis Van Gorsel, L. bisambergensis (Jaeger), L. cf. minor (Schlumberger), Pseudosiderolites vidali (Douville), and Siderolites gr. calcitrapoides Lamarck were determined in the formation. Based on this LBF assemblage data, the late Campanian-Maastrichtian age was assigned to the formation. The paleontological and sedimentological data indicate that the Harami Formation was deposited …


Update For Reactive Transport Modeling Of The Kızıldere Geothermal Field To Reduce Uncertainties In The Early Inspections, Selçuk Erol, Taylan Akin, Serhat Akin Jan 2023

Update For Reactive Transport Modeling Of The Kızıldere Geothermal Field To Reduce Uncertainties In The Early Inspections, Selçuk Erol, Taylan Akin, Serhat Akin

Turkish Journal of Earth Sciences

The development of carbon capture and storage techniques has become essential to reduce and mitigating CO2 emissions to the atmosphere. CarbFix1 and CarbFix2 projects carried out in Iceland demonstrated that the emissions of waste CO2 gas from geothermal power plants can be captured and mixed with the effluent geofluid and subsequently injected back into the geothermal reservoir. This experience gained in the CarbFix projects expanded into other geothermal fields around Europe, and one of the demonstration sites is the geothermal field in Turkey, Kızıldere. This paper focuses on the results of an updated study on early field evaluations with reactive …


Fired Shards From Selected Ancient Anatolian Ceramics: A Brief Review Of Their Mineralogical Nature And Pedological?Microstructural Evolution, Seli̇m Kapur, Selahatti̇n Kadi̇r, Gilbert Kelling, Erhan Akça, Mustafa Topaksu, Necdet Sakarya, Zehra Yeği̇ngi̇l, Muhsi̇n Eren, Ewart Adsil Fitzpatrick Jan 2023

Fired Shards From Selected Ancient Anatolian Ceramics: A Brief Review Of Their Mineralogical Nature And Pedological?Microstructural Evolution, Seli̇m Kapur, Selahatti̇n Kadi̇r, Gilbert Kelling, Erhan Akça, Mustafa Topaksu, Necdet Sakarya, Zehra Yeği̇ngi̇l, Muhsi̇n Eren, Ewart Adsil Fitzpatrick

Turkish Journal of Earth Sciences

This review is concerned with some key features observed within grouped samples of ancient ceramics that provide important evidence concerning the selection of appropriate raw materials and the evolution of the firing technologies employed in their production. It also demonstrates the importance of distinguishing and accounting for the mineralogical and microstructural attributes and identifying the processes responsible for the microstructural evolution of these ancient ceramics. The mineralogy largely reflects both the nature of the raw materials used and the maximum temperatures achieved during firing, deduced from the presence of specific high temperature minerals (HTMs). The microstructural evolution processes, deduced by …


Climate Change As A Social Determinant Of Health: An Interactive Case-Based Learning Activity, Arindam Sarkar, Nital P Appelbaum, Rathi Asaithambi, Connie Tran, Doris Lin, Anjali Aggarwal, Stephanie Nguyen Jan 2023

Climate Change As A Social Determinant Of Health: An Interactive Case-Based Learning Activity, Arindam Sarkar, Nital P Appelbaum, Rathi Asaithambi, Connie Tran, Doris Lin, Anjali Aggarwal, Stephanie Nguyen

Faculty, Staff and Students Publications

INTRODUCTION: Despite consensus on climate change's impact on humans, medical schools have not widely adopted inclusion of environmental topics into their mandatory curriculum. This educational activity explicitly addresses climate change as one of the environmental determinants of health (EDH).

METHODS: We developed a required, 1-hour module for all first-year medical students. This interactive, case-based, small-group activity was incorporated into a curriculum within an advising program but could be run independently. Before and after the session, participants completed evaluations assessing knowledge gains and attitude shifts.

RESULTS: Of 183 first-year students, 155 completed both pre- and postmodule surveys. Participants' rating increased on …


Trends In Cigarette Smoking Among United States Adolescents, Maria C Mejia, Adedamola Adele, Robert S Levine, Charles H Hennekens, Panagiota Kitsantas Jan 2023

Trends In Cigarette Smoking Among United States Adolescents, Maria C Mejia, Adedamola Adele, Robert S Levine, Charles H Hennekens, Panagiota Kitsantas

Faculty, Staff and Students Publications

Background: Cigarette smoking remains the leading avoidable cause of premature death in the United States, accounting for approximately 500,000, or 1 in 5, deaths annually. We explored trends in cigarette smoking among US adolescents.

Methods: We used data for adolescents in grades 9 through 12 from 1991 to 2021 from the Youth Risk Behavior Survey provided by the US Centers for Disease Control and Prevention. We explored trends overall as well as by sex, race/ethnicity, and school grade.

Results: All cigarette use—assessed as ever, occasional, frequent, or daily—among adolescents declined markedly from 1991 to 2021. Specifically, ever use significantly decreased …


Nonconsensual Family Obligations, Emily Stolzenberg Jan 2023

Nonconsensual Family Obligations, Emily Stolzenberg

Faculty Publications

Even as the pandemic has both highlighted and compounded the challenges many U.S. families face in meeting their members’ basic needs, efforts to expand public subsidies for caretaking have gained little traction. Scholars have identified many historical and practical reasons for Americans’ entrenched skepticism toward the welfare state. Ideas matter, too, and this Article uncovers and critiques one that works to limit collective financial responsibility for families: the conviction that family support obligations must be legitimated through consent.

In family law, as in liberal political theory, consent works to reconcile state regulation with individual freedom. But because consent is a …


Advances In Prosthetic Technology: A Perspective On Ethical Considerations For Development And Clinical Translation, Hayden Gavette, Cody L Mcdonald, Kristin Kostick-Quenet, Ashley Mullen, Bijan Najafi, M G Finco Jan 2023

Advances In Prosthetic Technology: A Perspective On Ethical Considerations For Development And Clinical Translation, Hayden Gavette, Cody L Mcdonald, Kristin Kostick-Quenet, Ashley Mullen, Bijan Najafi, M G Finco

Faculty, Staff and Students Publications

Technological advancements of prostheses in recent years, such as haptic feedback, active power, and machine learning for prosthetic control, have opened new doors for improved functioning, satisfaction, and overall quality of life. However, little attention has been paid to ethical considerations surrounding the development and translation of prosthetic technologies into clinical practice. This article, based on current literature, presents perspectives surrounding ethical considerations from the authors' multidisciplinary views as prosthetists (HG, AM, CLM, MGF), as well as combined research experience working directly with people using prostheses (AM, CLM, MGF), wearable technologies for rehabilitation (MGF, BN), machine learning and artificial intelligence …


Adeno-Associated Virus 8 Delivers An Immunomodulatory Peptide To Mouse Liver More Efficiently Than To Rat Liver, Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton Jan 2023

Adeno-Associated Virus 8 Delivers An Immunomodulatory Peptide To Mouse Liver More Efficiently Than To Rat Liver, Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton

Faculty, Staff and Students Publications

Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. Several of its analogs are some of the most potent and selective blockers of this channel. However, like most biologics, ShK and its analogs require injections for their delivery, and repeated injections reduce patient compliance during the treatment of chronic diseases. We hypothesized that inducing the expression of an ShK analog by hepatocytes would remove the requirement for frequent injections and lead to a …


Combating Hypertension Beyond Genome-Wide Association Studies: Microbiome And Artificial Intelligence As Opportunities For Precision Medicine, Sachin Aryal, Ishan Manandhar, Xue Mei, Beng S Yeoh, Ramakumar Tummala, Piu Saha, Islam Osman, Jasenka Zubcevic, David J Durgan, Matam Vijay-Kumar, Bina Joe Jan 2023

Combating Hypertension Beyond Genome-Wide Association Studies: Microbiome And Artificial Intelligence As Opportunities For Precision Medicine, Sachin Aryal, Ishan Manandhar, Xue Mei, Beng S Yeoh, Ramakumar Tummala, Piu Saha, Islam Osman, Jasenka Zubcevic, David J Durgan, Matam Vijay-Kumar, Bina Joe

Faculty, Staff and Students Publications

The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have placed much emphasis on the identification of genetic factors contributing to HTN. As a result, over 1,500 genetic alleles have been associated with human HTN. Mapping studies using genetic models of HTN have yielded hundreds of blood pressure (BP) loci but their individual effects on BP are minor, which limits opportunities to target them in the clinic. The value of collecting genome-wide association data is evident in ongoing research, which is beginning to utilize these data …


Friction-In-Design Regulation As 21st Century Time, Place, And Manner Restriction, Brett Frischmann, Susan Benesch Jan 2023

Friction-In-Design Regulation As 21st Century Time, Place, And Manner Restriction, Brett Frischmann, Susan Benesch

Faculty Publications

Digital networked society needs friction-in-design regulation that targets the digital architectures, supposedly smart (data-driven, algorithmic) systems, and interfaces that shape human interactions, behavior, and will (beliefs, preferences, values, intentions). The relentless push to eliminate friction for the sake of efficiency has hidden social costs that affect basic human capabilities and society. A general course correction is needed.

Friction in the digital networked environment can come in many forms. It can be as simple as a time delay prior to publishing a social media post, a notice that provides salient information coupled with a nudge toward actual deliberation, or a query …


Open-Source, Highly Efficient, Post-Acquisition Synchronization For 4d Dual-Contrast Imaging Of The Mouse Embryonic Heart Over Development With Optical Coherence Tomography, Andre C Faubert, Irina V Larina, Shang Wang Jan 2023

Open-Source, Highly Efficient, Post-Acquisition Synchronization For 4d Dual-Contrast Imaging Of The Mouse Embryonic Heart Over Development With Optical Coherence Tomography, Andre C Faubert, Irina V Larina, Shang Wang

Faculty, Staff and Students Publications

Dynamic imaging of the beating embryonic heart in 3D is critical for understanding cardiac development and defects. Optical coherence tomography (OCT) plays an important role in embryonic heart imaging with its unique imaging scale and label-free contrasts. In particular, 4D (3D + time) OCT imaging enabled biomechanical analysis of the developing heart in various animal models. While ultrafast OCT systems allow for direct volumetric imaging of the beating heart, the imaging speed remains limited, leading to an image quality inferior to that produced by post-acquisition synchronization. As OCT systems become increasingly available to a wide range of biomedical researchers, a …


Differential Expression Of Programmed Death 1 (Pd-1) On Various Immune Cells And Its Role In Human Leprosy, Mohammad Tarique, Huma Naz, Mohd Suhail, Ali Turan, Chaman Saini, Naoshad Muhammad, Hari Shankar, Torki A Zughaibi, Tabish H Khan, Neena Khanna, Alpana Sharma Jan 2023

Differential Expression Of Programmed Death 1 (Pd-1) On Various Immune Cells And Its Role In Human Leprosy, Mohammad Tarique, Huma Naz, Mohd Suhail, Ali Turan, Chaman Saini, Naoshad Muhammad, Hari Shankar, Torki A Zughaibi, Tabish H Khan, Neena Khanna, Alpana Sharma

2020-Current year OA Pubs

Leprosy is a chronic bacterial disease caused by


Seventy-Five Years Of Service: An Overview Of The College Of American Pathologists' Proficiency Testing Program In Histocompatibility And Identity Testing, H Cliff Sullivan, Manish J Gandhi, Sujata Gaitonde, Ramya Narasimhan, Ketevan Gendzekhadze, Soumya Pandey, Rhonda K Roby, George C Maha, Harmeet Kaur, Jennifer J Schiller, Julie Mcdowell, Maria Smith, Chang Liu, Gerald P Morris Jan 2023

Seventy-Five Years Of Service: An Overview Of The College Of American Pathologists' Proficiency Testing Program In Histocompatibility And Identity Testing, H Cliff Sullivan, Manish J Gandhi, Sujata Gaitonde, Ramya Narasimhan, Ketevan Gendzekhadze, Soumya Pandey, Rhonda K Roby, George C Maha, Harmeet Kaur, Jennifer J Schiller, Julie Mcdowell, Maria Smith, Chang Liu, Gerald P Morris

2020-Current year OA Pubs

The Histocompatibility and Identity Testing Committee offers an overview of the College of American Pathologists' (CAP) Proficiency Testing (PT) program, commemorating its significant 75th anniversary in 2024. The CAP PT program has undergone significant growth and evolution over the years, ultimately achieving Centers for Medicare and Medicaid Services approval. In 1979, CAP's partnership with the American Association for Clinical Histocompatibility Testing marked a pivotal moment, leading to the creation of the first proficiency testing survey in 1980. This laid the foundation for various PT programs managed by the CAP Histocompatibility and Identity Testing Committee, including HLA antibody testing, HLA molecular …


Cerebral Microdialysis And Glucopenia In Traumatic Brain Injury: A Review, Himanshu Sharma, John P Mcginnis, Katherine E Kabotyanski, Shankar P Gopinath, Jerry C Goodman, Claudia Robertson, Jovany Cruz Navarro Jan 2023

Cerebral Microdialysis And Glucopenia In Traumatic Brain Injury: A Review, Himanshu Sharma, John P Mcginnis, Katherine E Kabotyanski, Shankar P Gopinath, Jerry C Goodman, Claudia Robertson, Jovany Cruz Navarro

Faculty, Staff and Students Publications

Traditionally, intracranial pressure (ICP) and partial brain tissue oxygenation (PbtO2) have been the primary invasive intracranial measurements used to guide management in patients with severe traumatic brain injury (TBI). After injury however, the brain develops an increased metabolic demand which may require an increment in the oxidative metabolism of glucose. Simultaneously, metabolic, and electrical dysfunction can lead to an inability to meet these demands, even in the absence of ischemia or increased intracranial pressure. Cerebral microdialysis provides the ability to accurately measure local concentrations of various solutes including lactate, pyruvate, glycerol and glucose. Experimental and clinical data demonstrate that such …


Engineered Cd4 T Cells Expressing A Membrane Anchored Viral Inhibitor Restrict Hiv-1 Through Cis And Trans Mechanisms, Weiming Wang, Khanghy Truong, Chaobaihui Ye, Suman Sharma, Huan He, Lihong Liu, Michael Wen, Anisha Misra, Paul Zhou, Jason T Kimata Jan 2023

Engineered Cd4 T Cells Expressing A Membrane Anchored Viral Inhibitor Restrict Hiv-1 Through Cis And Trans Mechanisms, Weiming Wang, Khanghy Truong, Chaobaihui Ye, Suman Sharma, Huan He, Lihong Liu, Michael Wen, Anisha Misra, Paul Zhou, Jason T Kimata

Faculty, Staff and Students Publications

HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient. Neutralizing antibodies and entry inhibitors effectively block cell-free HIV-1, but with few exceptions, they display much less inhibitory activity against cell-mediated HIV-1 transmission. Previously, we showed that engineering HIV-1 target cells by genetically linking single-chain variable fragments (scFvs) of antibodies to glycosyl phosphatidylinositol (GPI) potently blocks infection by cell-free virions and cell-mediated infection by immature dendritic cell (iDC)-captured HIV-1. Expression of scFvs on CD4


Future Directions In Psychiatric Neurosurgery: Proceedings Of The 2022 American Society For Stereotactic And Functional Neurosurgery Meeting On Surgical Neuromodulation For Psychiatric Disorders, Frederick L Hitti, Alik S Widge, Patricio Riva-Posse, Donald A Malone, Michael S Okun, Maryam M Shanechi, Kelly D Foote, Sarah H Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S Kubu, Winston Chiong, Jennifer A Chandler, Rafael Carbunaru, Binith Cheeran, Robert S Raike, Rachel A Davis, Casey H Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K Bick, Cameron C Mcintyre, R Mark Richardson, Darin D Dougherty, Brian H Kopell, Jennifer A Sweet, Wayne K Goodman, Sameer A Sheth, Nader Pouratian Jan 2023

Future Directions In Psychiatric Neurosurgery: Proceedings Of The 2022 American Society For Stereotactic And Functional Neurosurgery Meeting On Surgical Neuromodulation For Psychiatric Disorders, Frederick L Hitti, Alik S Widge, Patricio Riva-Posse, Donald A Malone, Michael S Okun, Maryam M Shanechi, Kelly D Foote, Sarah H Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S Kubu, Winston Chiong, Jennifer A Chandler, Rafael Carbunaru, Binith Cheeran, Robert S Raike, Rachel A Davis, Casey H Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K Bick, Cameron C Mcintyre, R Mark Richardson, Darin D Dougherty, Brian H Kopell, Jennifer A Sweet, Wayne K Goodman, Sameer A Sheth, Nader Pouratian

Faculty, Staff and Students Publications

OBJECTIVE: Despite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a potential therapy for persistent disabling disease, however it has not yet gained widespread adoption. In 2016, the American Society for Stereotactic and Functional Neurosurgery (ASSFN) convened a meeting with leaders in the field to discuss a roadmap for the path forward. A follow-up meeting in 2022 aimed to review the current state of the field and to identify critical barriers and milestones for progress. …


Postsurgical Morbidity And Mortality Favorably Informs Deep Brain Stimulation For New Indications Including Schizophrenia And Schizoaffective Disorder, Judith M Gault, Patrick Hosokawa, Daniel Kramer, Elyn R Saks, Paul S Appelbaum, John A Thompson, Ann Olincy, Nicola Cascella, Akira Sawa, Wayne Goodman, Nidal Moukaddam, Sameer A Sheth, William S Anderson, Rachel A Davis Jan 2023

Postsurgical Morbidity And Mortality Favorably Informs Deep Brain Stimulation For New Indications Including Schizophrenia And Schizoaffective Disorder, Judith M Gault, Patrick Hosokawa, Daniel Kramer, Elyn R Saks, Paul S Appelbaum, John A Thompson, Ann Olincy, Nicola Cascella, Akira Sawa, Wayne Goodman, Nidal Moukaddam, Sameer A Sheth, William S Anderson, Rachel A Davis

Faculty, Staff and Students Publications

BACKGROUND: Deep brain stimulation (DBS) shows promise for new indications like treatment-refractory schizophrenia in early clinical trials. In the first DBS clinical trial for treatment refractory schizophrenia, despite promising results in treating psychosis, one of the eight subjects experienced both a symptomatic hemorrhage and an infection requiring device removal. Now, ethical concerns about higher surgical risk in schizophrenia/schizoaffective disorder (SZ/SAD) are impacting clinical trial progress. However, insufficient cases preclude conclusions regarding DBS risk in SZ/SAD. Therefore, we directly compare adverse surgical outcomes for all surgical procedures between SZ/SAD and Parkinson's disease (PD) cases to infer relative surgical risk relevant to …