Digital Commons Network^™

Aversive Reaction Between Disulfiram And Betel Quid Among Inpatients With Alcohol Use Disorder In Bhutan: A Preliminary Study, Ugyen Dem, Zimba Letho, Chencho Dorji, Damber K. Nirola, Sonam Choki, Tashi Dorji, Pelden Chejor

Research outputs 2022 to 2026

Betel Quid (BQ) is commonly used in the Asia-Pacific region. Disulfiram is prescribed for people with alcohol use disorders (PwAUDs) after the completion of detoxification as an alternative to rehabilitation. This prospective observational study reports the aversive reactions and common symptoms of Disulfiram and BQ in PwAUDs. Participants included PwAUDs admitted to the psychiatric ward at the Jigme Dorji Wangchuck National Referral Hospital for detoxification, who were on Disulfiram and using BQ at the same time. Aversive reactions between Disulfiram and BQ were observed for 100 patients over a year. Twenty participants showed aversive reactions between BQ and Disulfiram. Common …

Global Online Trade In Primates For Pets, Vincent Nijman, Thais Q. Morcatty, Hani R. El Bizri, Hassan Al-Razi, Andie Ang, Ahmad Ardiansyah, Sadek Atoussi, Daniel Bergin, Sarah Bell, Franciany Braga-Pereira, Marco Campera, Nabajit Das, Felipe E. Silva, Kim Feddema, Grace Foreman, Anna Fourage, Smitha D. Gnanaolivu, Malene F. Hansen, Elena Račevska, Brittany C. Rapone, Ganga R. Regmi, Chris R. Shepherd, Sofiya Shukhova, Penthai Siriwat, Jaima H. Smith, Seyed A. M. M. Tabar, Aline S. Tavares, Ariana V. Weldon, Angelina Wilson, Nobuyuki Yamaguchi, Mingxia Zhang, Magdalena S. Svensson, K. Anne-Isola Nekaris

Research outputs 2022 to 2026

The trade in primates as pets is a global enterprise and as access to the Internet has increased, so too has the trade of live primates online. While quantifying primate trade in physical markets is relatively straightforward, limited insights have been made into trade via the Internet. Here we followed a three-pronged approach to estimate the prevalence and ease of purchasing primates online in countries with different socioeconomic characteristics. We first conducted a literature review, in which we found that Malaysia, Thailand, the USA, Ukraine, South Africa, and Russia stood out in terms of the number of primate individuals being …

Associations Of Physical Activity And Quality Of Life In Parapneumonic Effusion Patients, Pedro Lopez, Deirdre B. Fitzgerald, Joanne A. Mcveigh, Arash Badiei, Sanjeevan Muruganandan, Robert U. Newton, Leon Straker, Yun C. G. Lee, Carolyn J. Peddle-Mcintyre

Research outputs 2022 to 2026

Introduction Little is known about activity behaviours and quality of life (QoL) of patients with parapneumonic pleural effusions (PPE) after hospital discharge. This study is a secondary analysis of a randomised trial (dexamethasone versus placebo) for hospitalised patients with PPE. We: 1) described the patients’ activity behaviour patterns and QoL measured at discharge and at 30 days post-discharge; and 2) examined the association between activity behaviours and QoL scores. Methods Activity behaviour (7-day accelerometry; Actigraph GT3X+) and QoL (Medical Outcomes Study Short-Form 36) were assessed. Repeated measures analysis of covariance controlling for baseline values and a series of linear regression …

Bidirectional Causality Between Immunoglobulin G N-Glycosylation And Metabolic Traits: A Mendelian Randomization Study, Xiaoni Meng, Weijie Cao, Di Liu, Isinta M. Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Research outputs 2022 to 2026

Although the association between immunoglobulin G (IgG) N-glycosylation and metabolic traits has been previously identified, the causal association between them remains unclear. In this work, we used Mendelian randomization (MR) analysis to integrate genome-wide association studies (GWASs) and quantitative trait loci (QTLs) data in order to investigate the bidirectional causal association of IgG N-glycosylation with metabolic traits. In the forward MR analysis, 59 (including nine putatively causal glycan peaks (GPs) for body mass index (BMI) (GP1, GP6, etc.) and seven for fasting plasma glucose (FPG) (GP1, GP5, etc.)) and 15 (including five putatively causal GPs for BMI (GP2, GP11, etc.) …

Coagulation Factors And Natural Anticoagulants As Surrogate Markers Of Preeclampsia And Its Subtypes: A Case-Control Study In A Ghanaian Population, Selina Mintaah, Enoch O. Anto, Wina I. O. Boadu, Benedict Sackey, Lily A. Boateng, Ezekiel Ansah, Emmanuel E. Korsah, Joseph Frimpong, Valentine C. K. T. Tamakloe, Peter K. Selleh, David A. Afrifa, Abdul-Razak Saasi, Ebenezer Senu, Lawrence A. Duah, Stephen Opoku, John P. Amoah, Patrick Adu, Joseph Boachie, Dorcas A. Nyamekye, David S. Sackey, Yaw A. Wiafe, Otchere Addai-Mensah

Research outputs 2022 to 2026

Preeclampsia (PE) is associated with endothelial injury and hemostatic abnormalities. However, the diagnostic role of coagulation parameters and natural anticoagulants in predicting PE has not been explored in Ghana. This study assessed plasma levels of these factors as surrogate markers of PE and its subtypes. This case-control study included 90 women with PE (cases) and 90 normotensive pregnant women (controls). Blood samples were drawn for the estimation of complete blood count and coagulation tests. The prothrombin time (PT), activated partial thromboplastin time (APTT), and the calculation of the international normalized ratio (INR) were determined by an ACL elite coagulometer while …

Employability For Inclusion: The Urgent Need For A Biopsychosocial Model Perspective, Mollie Dollinger, Tim Corcoran, Denise Jackson, Sarah O'Shea

Research outputs 2022 to 2026

Definitions of disability are changing, shifting from a narrow medical diagnosis to a biopsychosocial model of disability, where disability is conceptualised as a series of relational conditions that can potentially disadvantage individuals within environments. Implications of this new understanding of disability will have significant effects in the higher education sector, where there is increasing participation of disabled students. In this paper, we discuss one aspect of these implications through the topic of graduate employability. In doing so, we generate a new concept ‘Employability for Inclusion’ that can be utilised as an equity-focused lens for universities to consider how employability initiatives …

Experimental Study On The Mechanical Controlling Factors Of Fracture Plugging Strength For Lost Circulation Control In Shale Gas Reservoir, Chengyuan Xu, Lingmao Zhu, Feng Xu, Yili Kang, Haoran Jing, Zhenjiang You

Research outputs 2022 to 2026

The geological conditions of shale reservoir present several unique challenges. These include the extensive development of multi-scale fractures, frequent losses during horizontal drilling, low success rates in plugging, and a tendency for the fracture plugging zone to experience repeated failures. Extensive analysis suggests that the weakening of the mechanical properties of shale fracture surfaces is the primary factor responsible for reducing the bearing capacity of the fracture plugging zone. To assess the influence of oil-based environments on the degradation of mechanical properties in shale fracture surfaces, rigorous mechanical property tests were conducted on shale samples subsequent to their exposure to …

Gen Z And The Flight Shame Movement: Examining The Intersection Of Emotions, Biospheric Values, And Environmental Travel Behaviour In An Eastern Society, Ante Mandić, Sandeep K. Walia, S. Mostafa Rasoolimanesh

Research outputs 2022 to 2026

Using the norm activation model (NAM), our research delves into the impact of environmental concerns, and environmental self-assets on environmentally responsible travel behaviour (ENVRB), and the role of affective constructs (love for nature [LNA], respect for nature and flight shame) on travelling behaviour among Generation Z in India. Through a prediction-oriented and exploratory approach using partial least squares–structural equation modeling (PLS-SEM), our study reveals strong effects of environmental concerns and self-assets on responsible travel behaviour, and the mediating role of LNA in these relationships; the mediating role of respect for nature was insignificant. Furthermore, flight shame emerges as a strong …

Generalized Framework For Image And Video Object Segmentation Using Affinity Learning And Message Passing Gnns, Sundaram Muthu, Ruwan Tennakoon, Tharindu Rathnayake, Reza Hoseinnezhad, David Suter, Alireza Bab-Hadiashar

Research outputs 2022 to 2026

Despite significant amount of work reported in the computer vision literature, segmenting images or videos based on multiple cues such as objectness, texture and motion, is still a challenge. This is particularly true when the number of objects to be segmented is not known or there are objects that are not classified in the training data (unknown objects). A possible remedy to this problem is to utilize graph-based clustering techniques such as Correlation Clustering. It is known that using long range affinities (Lifted multicut), makes correlation clustering more accurate than using only adjacent affinities (Multicut). However, the former is computationally …

Influence Of Three-Dimensional Printing Parameters On Compressive Properties And Surface Smoothness Of Polylactic Acid Specimens, Hamed Bakhtiari, Mostafa Nikzad, Majid Tolouei-Rad

Research outputs 2022 to 2026

While the mechanical performance of fused filament fabrication (FFF) parts has been extensively studied in terms of the tensile and bending strength, limited research accounts for their compressive performance. This study investigates the effect of four process parameters (layer height, extrusion width, nozzle temperature, and printing speed) on the compressive properties and surface smoothness of FFF parts made of Polylactic Acid (PLA). The orthogonal Taguchi method was employed for designing the experiments. The surface roughness and compressive properties of the specimens were then measured and optimized using the analysis of variance (ANOVA). A microscopic analysis was also performed to identify …

Investigating The Potential Of High-Density Polyethylene And Nano Clay Asphalt-Modified Binders To Enhance The Rutting Resistance Of Asphalt Mixture, Ashraf Abdel-Raheem, Anmar Dulaimi, Ahmed S. Mohamed, Ghada S. Moussa, Yasin O. Özkılıç, Nuha Mashaan, Ramadhansyah P. Jaya, Talaat Abdel-Wahed

Research outputs 2022 to 2026

This study investigates the potential of two bitumen modifiers, high-density polyethylene (HDPE) and nano clay (NC), to enhance the rutting resistance of asphalt mixture. Four HDPE asphalt binders were prepared by mixing the HDPE at percentages of 2%, 4%, 6%, and 8% with the virgin binder, while four NC asphalt binders were produced by mixing the NC at percentages of 1%, 2%, 3%, and 4%. The consistency and flow of virgin binder, HDPE binders, and NC binders were evaluated by penetration, softening point, and viscosity tests. The results show a gradual increment in the binder stiffness by increasing the percentage …

Longitudinal Trajectories Of Basal Forebrain Volume In Normal Aging And Alzheimer's Disease, Ying Xia, Paul Maruff, Vincent Doré, Pierrick Bourgeat, Simon M. Laws, Christopher Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Jurgen Fripp

Research outputs 2022 to 2026

Dysfunction of the cholinergic basal forebrain (BF) system and amyloid- (A ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed A -PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and A status (A −, A +). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high A …

Making Open Scholarship More Equitable And Inclusive, Paul L. Arthur, Lydia Hearn, John C. Ryan, Nirmala Menon, Langa Khumalo

Research outputs 2022 to 2026

Democratizing access to information is an enabler for our digital future. It can transform how knowledge is created, preserved, and shared, and strengthen the connection between academics and the communities they serve. Yet, open scholarship is influenced by history and politics. This article explores the foundations underlying open scholarship as a quest for more just, equitable, and inclusive societies. It analyzes the origins of the open scholarship movement and explores how systemic factors have impacted equality and equity of knowledge access and production according to location, nationality, race, age, gender, and socio-economic circumstances. It highlights how the privileges of the …

Memory-Based Adaptive Sliding Mode Load Frequency Control In Interconnected Power Systems With Energy Storage, Farhad Farivar, Octavian Bass, Daryoush Habibi

Research outputs 2022 to 2026

This paper presents a memory-based adaptive sliding mode load frequency control (LFC) strategy aimed at minimizing the impacts of exogenous power disturbances and parameter uncertainties on frequency deviations in interconnected power systems with energy storage. First, the dynamic model of the system is constructed by considering the participation of the energy storage system (ESS) in the conventional decentralized LFC model of a multiarea power system. A disturbance observer (DOB) is proposed to generate an online approximation of the lumped disturbance. In order to enhance the transient performance of the system and effectively mitigate the adverse effects of power fluctuations on …

Perceived Destination Image Cohesion: A Comparison Study Of Attractions On The Grand Canal, China, Shan Jiang, Noel Scott, Li Tao, Shiqi Xiong, Yuan Qin

Research outputs 2022 to 2026

The Grand Canal is located in the north-eastern and central-eastern plains of China, running from Beijing in the north to Zhejiang province in the south, and is the longest canal in the world (1800 km) and a UNESCO World Heritage Site. From a tourism perspective, the Grand Canal can be considered as a linear heritage attraction linking many individual heritage sites. This research was conducted with a mixed qualitative–quantitative method in the 2021–2022 period. First, in-depth interviews with an unstructured methodology of image measurements were conducted to determine attributes of the perceived destination image (PDI) of the Grand Canal as …

Relieving The Gambling Itch Through Alcohol Consumption: The Impact Of Covid-19 Restrictions On Australian Casino Patrons, Tenghao Zhang, Pi-Shen Seet, Janice Redmond, Jalleh Sharafizad

Research outputs 2022 to 2026

This paper extends our understanding of how casino patrons are affected by COVID-19 restrictions and how they cope by substituting gambling with alcohol consumption. We conducted two studies using a nationwide survey sample collected in Australia during the pandemic lockdown. Study 1 compares the casino patrons with two reference groups (other gambling patrons and non-gambling individuals) and investigates the lockdown restrictions on respondents’ relational strength, and their potential impact on mental health and future prospects. Study 2 applies the stress-response dampening model (SRD) and tests how respondents used alcohol consumption to cope with the lack of access to casinos during …

Solidarity Tourism: A Pathway To Revitalising The Health Of Vulnerable War-Affected Populations?, Jun Wen, Fangli Hu, Danni Zheng, Ian Phau, Metin Kozak, Haifeng Hou, Wei Wang

Research outputs 2022 to 2026

The struggles of war are felt by all who occupy an affected region (and beyond), irrespective of whether they are in active combat. This experience has physical effects (e.g. injury, illness, malnutrition, disability, sexual violence, and/or death) and emotional impacts (e.g. posttraumatic stress disorder, depression, and anxiety) [1-3]. The terror associated with war disrupts lives and relationships, leaving individuals, families, and communities distressed. Due to such immediate and long-term adverse outcomes, war represents a highly destructive and enduring public health emergency [4]. . . .

Physical Layer Authenticated Image Encryption For Iot Network Based On Biometric Chaotic Signature For Mpfrft Ofdm System, Esam A. A. Hagras, Saad Aldosary, Haitham Khaled, Tarek Hassan

Research outputs 2022 to 2026

In this paper, a new physical layer authenticated encryption (PLAE) scheme based on the multi-parameter fractional Fourier transform–Orthogonal frequency division multiplexing (MP-FrFT-OFDM) is suggested for secure image transmission over the IoT network. In addition, a new robust multi-cascaded chaotic modular fractional sine map (MCC-MF sine map) is designed and analyzed. Also, a new dynamic chaotic biometric signature (DCBS) generator based on combining the biometric signature and the proposed MCC-MF sine map random chaotic sequence output is also designed. The final output of the proposed DCBS generator is used as a dynamic secret key for the MPFrFT OFDM system in which …

Testing Campaign Slogans Designed To Motivate Older People To Be More Physically Active, Simone Pettigrew, Michelle I. Jongenelis, Liyuwork M. Dana, Rajni Rai, Ben Jackson, Robert U. Newton

Research outputs 2022 to 2026

Objectives and importance of study: Being physically active is critical for healthy ageing, yet many older people do not meet physical activity guidelines. The aim of this study was to test the relative effectiveness of five previously identified campaign slogans designed to encourage older people to be more physically active: ‘Be active 30–60 minutes a day to stay fit and well’; ‘Move more, live longer’; ‘Stay fit to stay functional’; ‘This is your time – enjoy being strong and active’; and ‘Use it or lose it’. Study type: Online experiment Methods: A total of 1200 Australians aged 50 years and …

Hydrogen-Wettability Alteration Of Indiana Limestone In The Presence Of Organic Acids And Nanofluid, Mirhasan Hosseini, Rossen Sedev, Mujahid Ali, Muhammad Ali, Jalal Fahimpour, Alireza Keshavarz, Sefan Iglauer

Research outputs 2022 to 2026

This study focuses on the wettability alteration (changing from a hydrophobic state to a hydrophilic state) of Indiana limestone for hydrogen (H₂) geological storage. We examine the effect of hexanoic acid C₆, lauric acid C₁₂, and stearic acid C₁₈, on the wettability of Indiana limestone at ambient (298 K and 0.1 MPa) and reservoir (323 K and 8.27 MPa) conditions. The effects of silica nanofluids (silica with deionized water) at various concentrations (0.1 wt%, 0.25 wt%, and 0.5 wt%) on the wettability reversal of stearic-aged samples were tested at ambient and reservoir …

Comparing Clinico-Demographics And Neuropsychiatric Symptoms For Immigrant And Non-Immigrant Aged Care Residents Living With Dementia: A Retrospective Cross-Sectional Study From An Australian Dementia-Specific Support Service, Pelden Chejor, Mustafa Atee, Patricia Cain, Daniel Whiting, Thomas Morris, Davina Porock

Research outputs 2022 to 2026

Background:

Neuropsychiatric symptoms of dementia such as agitation and aggression are common in people living with dementia. The presentation of neuropsychiatric symptoms is influenced by the cultural background of people living with dementia. Further, identifying factors contributing to neuropsychiatric symptoms may be complicated if people living with dementia are immigrants or from non-English-speaking backgrounds. Most of what is known about differences in neuropsychiatric symptoms between racial and ethnic groups living with dementia come from community-based samples. This study investigated differences in clinico-demographics and neuropsychiatric symptoms between immigrants and non-immigrants living with dementia in residential aged care homes who were referred …

Blue Carbon Opportunities: Seagrass Carbon Storage And Accumulation Rates At Trang, Thailand, Paul Lavery, Anna Lafratta, Rujinun Palahan, Maneewan Sanlee, Milica Stankovic, Janmanee Panyawai, Oscar Serrano, Pere Masque´

Research outputs 2022 to 2026

Report prepared as a contribution to the IKI Project “Conservation of biodiversity, seagrass ecosystems and their services – safeguarding food security and resilience in vulnerable coastal communities in a changing climate” funded through the International Klimate Initiative (IKI).

The IKI Project is a partnership between the CMS, Edith Cowan University, Project Seagrass, Seagrass Watch, Murdoch University, MRS, Blue Ventures, SAN, C3, ZSL, MareCet and Yapeka. The collaboration enhances the understanding of seagrass ecosystem services and the capacity to develop and deliver science-based policy solutions in seagrass conservation. It brings together scientists, policy experts, business development experts and conservation NGOs across …

Blue Carbon Opportunities: Seagrass Carbon Storage And Accumulation Rates At North Minahasa And Sangihe Island, Indonesia, Paul Lavery, Anna Lafratta, Akbar Ario Digdo, Abie Ariyo Dandoro, Citra Septiani, Topan Cahyono, Oscar Serrano, Pere Masque´

Research outputs 2022 to 2026

Report prepared as a contribution to the Seagrass Ecosystem Services Project “Conservation of biodiversity, seagrass ecosystems and their services – safeguarding food security and resilience in vulnerable coastal communities in a changing climate” funded through the International Klimate Initiative (IKI).

The SES Project is a partnership between the CMS, Edith Cowan University, Yapeka, Project Seagrass, Seagrass Watch, Murdoch University, MRS, Blue Ventures, SAN, C3, ZSL, and MareCet. The collaboration enhances the understanding of seagrass ecosystem services and the capacity to develop and deliver science-based policy solutions in seagrass conservation. It brings together scientists, policy experts, business development experts and conservation …

Blue Carbon Opportunities: Seagrass Carbon Storage And Accumulation Rates At Johor And Penang, Malaysia, Paul Lavery, Anna Lafratta, Dhivya Nair, Louisa Ponnampalam, Jol Ern Ng, Fairul Izmal Jamal Hisne, Oscar Serrano, Pere Masque´

Research outputs 2022 to 2026

Report prepared as a contribution to the IKI Project “Conservation of biodiversity, seagrass ecosystems and their services – safeguarding food security and resilience in vulnerable coastal communities in a changing climate.

The IKI Seagrass Ecosystem Services Project is a partnership between the CMS, Edith Cowan University, Project Seagrass, Seagrass Watch, Murdoch University, MRS, Blue Ventures, SAN, C3, ZSL, MareCet and Yapeka. The collaboration enhances the understanding of seagrass ecosystem services and the capacity to develop and deliver science-based policy solutions in seagrass conservation. It brings together scientists, policy experts, business development experts and conservation NGOs across the globe to provide …

Relationship Between Dietary Intake And Erythrocyte Pufa In Adolescents From A Western Australian Cohort, Fuzhen Wan, Feng Pan, Trevor A. Mori, Therese A. O’Sullivan, Lawrence J. Beilin, Wendy H. Oddy

Research outputs 2022 to 2026

Background:

Population-based studies show that the intake of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) are associated with a range of health conditions. Therefore, the reliability of food frequency questionnaires (FFQ) as rapid and easily accessible screening tools for PUFA intake deserve investigation.

Objective:

We aimed to assess the relationship between erythrocyte fatty acids and fatty acid intake collected using the Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire in an adolescent cohort.

Design:

A cross-sectional study using data from 1155 young adolescents participating in the 14-year follow-up of the Raine Study. Bland–Altman plots were used …

Inhibition Of Mirna Associated With A Disease-Specific Signature And Secreted Via Extracellular Vesicles Of Systemic Lupus Erythematosus Patients Suppresses Target Organ Inflammation In A Humanized Mouse Model, Nicholas A Young, Emily Schwarz, Braden M Zeno, Shane Bruckner, Rosana A Mesa, Kyle Jablonski, Lai-Chu Wu, Elisha D O Roberson, Wael N Jarjour

2020-Current year OA Pubs

INTRODUCTION: Distinct, disease-associated intracellular miRNA (miR) expression profiles have been observed in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematous (SLE) patients. Additionally, we have identified novel estrogenic responses in PBMCs from SLE patients and demonstrated that estrogen upregulates toll-like receptor (TLR)7 and TLR8 expression. TLR7 and TLR8 bind viral-derived single-stranded RNA to stimulate innate inflammatory responses, but recent studies have shown that miR-21, mir-29a, and miR-29b can also bind and activate these receptors when packaged and secreted in extracellular vesicles (EVs). The objective of this study was to evaluate the association of EV-encapsulated small RNA species in SLE …

Valorisation Of Crustacean And Bivalve Processing Side Streams For Industrial Fast Time-To-Market Products: A Review From The European Union Regulation Perspective, Yang Zou, Marc Heyndrickx, Jane Debode Jane Debode, Katleen Raes, Donatella De Pascale, Patrice Behan, Michelle Giltrap, Christine O'Connor, Runar Gjerp Solstad, Kjersi Lian, Themistoklis Altintzoglou, Ragnhild Dragoy, Nathalie Maria Scheers, Ingrid Undeland, Johan Robbens

Articles

A massive amount of crustaceans and bivalves are consumed each year, leading to millions of tons of processing side streams from the seafood industry. Considering the current trend of (bio)circular and zero-waste food production, crustacean and bivalve processing side streams (CBPS) seem a promising and emerging resource for producing high-value-added products. This paper highlights the general composition of CBPS with high commercial values, namely, protein, lipids, carotenoids, minerals and chitins. The extraction strategies of these fractions, including conventional chemical and environmentally friendly methods, are also discussed. This review presents and summarises CBPS as raw materials for developing fast time-to-market products …

Association Of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension Of Survival Among Patients With Newly Diagnosed And Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial, Linda M Liau, Jian L Campian, George Ansstas, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.

OBJECTIVE: To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.

DESIGN, SETTING, AND PARTICIPANTS: This phase 3, prospective, externally controlled nonrandomized trial compared overall survival (OS) in patients with newly diagnosed glioblastoma (nGBM) and recurrent glioblastoma (rGBM) treated with DCVax-L plus SOC vs contemporaneous matched external control patients treated with SOC. This international, multicenter trial was conducted at 94 sites in 4 countries from August 2007 to …

Eliminating Central Line Associated Bloodstream Infections In Pediatric Oncology Patients: A Quality Improvement Effort, Daniel N. Willis, Karen Looper, Rema A. Malone, Barbara Ricken, Ashley Slater, Amanda Fuller, Meagan Mccaughey, Angela Niesen, Joan R. Smith, Beverly Brozanski

2020-Current year OA Pubs

UNLABELLED: Central Line-Associated Bloodstream Infections (CLABSI) are the largest contributor to harm across the Children's Hospital's Solutions for Patient Safety network. Pediatric hematology/oncology (PHO) patients are at increased risk for CLABSI due to multiple factors. Consequently, traditional CLABSI prevention strategies are insufficient to eliminate CLABSI in this high-risk population.

METHODS: Our SMART aim was to reduce the CLABSI rate by 50% from a baseline of 1.89/1000 central line days to less than 0.9/1000 central line days by December 31, 2021. We created a multidisciplinary team being mindful to identify roles and responsibilities upfront. We developed a key driver diagram and …

Diversity And Evolution Of Computationally Predicted T Cell Epitopes Against Human Respiratory Syncytial Virus, Jiani Chen, Swan Tan, Vasanthi Avadhanula, Leonard Moise, Pedro A Piedra, Anne S De Groot, Justin Bahl

Faculty, Staff and Students Publications

Human respiratory syncytial virus (RSV) is a major cause of lower respiratory infection. Despite more than 60 years of research, there is no licensed vaccine. While B cell response is a major focus for vaccine design, the T cell epitope profile of RSV is also important for vaccine development. Here, we computationally predicted putative T cell epitopes in the Fusion protein (F) and Glycoprotein (G) of RSV wild circulating strains by predicting Major Histocompatibility Complex (MHC) class I and class II binding affinity. We limited our inferences to conserved epitopes in both F and G proteins that have been experimentally …