Digital Commons Network^™

Decoding The Mechanism Of Hypertension Through Multiomics Profiling, Eric Adua

Research outputs 2022 to 2026

Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregulated genes that are linked to hypertension. Moreover, post-genomic biomarkers, from the emerging fields of transcriptomics, proteomics, glycomics and lipidomics, have provided new insights into the molecular underpinnings of hypertension. In this paper, we review the pathophysiology of hypertension, and highlight the multi-omics approaches for hypertension prediction and diagnosis.

Plasma Aβ42/40 Ratio, P-Tau181, Gfap, And Nfl Across The Alzheimer's Disease Continuum: A Cross-Sectional And Longitudinal Study In The Aibl Cohort, Pratishtha Chatterjee, Steve Pedrini, James D. Doecke, Rohith Thota, Victor L. Villemagne, Vincent Doré, Abhay K. Singh, Penghao Wang, Stephanie Rainey-Smith, Christopher Fowler, Kevin Taddei, Hamid R. Sohrabi, Mark P. Molloy, David Ames, Paul Maruff, Christopher C. Rowe, Colin L. Masters, Ralph N. Martins, Aibl Research Group

Research outputs 2022 to 2026

Introduction:

Plasma amyloid beta (Aβ)1-42/Aβ1-40 ratio, phosphorylated-tau181 (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) are putative blood biomarkers for Alzheimer's disease (AD). However, head-to-head cross-sectional and longitudinal comparisons of the aforementioned biomarkers across the AD continuum are lacking.

Methods:

Plasma Aβ1-42, Aβ1-40, p-tau181, GFAP, and NfL were measured utilizing the Single Molecule Array (Simoa) platform and compared cross-sectionally across the AD continuum, wherein Aβ-PET (positron emission tomography)–negative cognitively unimpaired (CU Aβ−, n = 81) and mild cognitive impairment (MCI Aβ−, n = 26) participants were compared with Aβ-PET–positive participants across the AD continuum (CU Aβ+, n = …

Do Physiological Variables Predict The Need For Transport To Hospital From Music Festivals? An Analysis Of Australian Festival Data, Ned Douglas, Jake Donovan, James Carew, Kayla Brouwer, Ebony Edwards, Mitchell Gibson, Jacqueline Leverett, Joseph Paul, Lachlan Holbery-Morgan, Jessica Pritchard, Elyssia Bourke, Erin Smith

Research outputs 2022 to 2026

Objective:

Using physiological markers to detect patients at risk of deterioration is common. Deaths at music festivals in Australia prompted scrutiny of tools to identify critically unwell patients for transport to hospital. This study evaluated initial physiological parameters to identify patients selected for transport to hospital from a music festival.

Methods:

A retrospective audit of 2045 presentations at music festivals in Victoria, Australia, was performed. Presentation heart rate, systolic blood pressure, respiratory rate, oxygen saturation, temperature, and Glasgow Coma Scale were assessed using area under the receiver operating characteristic curve (AUROC) analysis, with a prespecified threshold of 0.7.

Results:

The …

Supply Chain Insights From Social Media Users’ Responses To Panic Buying During Covid-19: The Herd Mentality, Violetta Wilk, Saiyidi Mat Roni, Ferry Jie

Research outputs 2022 to 2026

Purpose:

This study applied the herd mentality theory to explore local and global social media users’ responses to panic buying across the USA, UK and Australia during the COVID-19 crisis to understand the implications on operations and supply chains.

Design/methodology/approach:

A total of 208,806 social media user-generated content (UGC) pieces were collected from Twitter in three countries – the USA, UK and Australia. The analysis of this big qualitative data was performed using machine learning–based software – Leximancer.

Findings:

Positive and negative sentiment towards panic buying during the COVID-19 crisis was observed in the UGC. No significant differences in social …

‘It Was Just As Political As It Was Pragmatic’: The (In)Formal Roles And Policy Work Of ‘Curriculum Leaders’ In A Federated Education Context, Karen Lambert, Dawn Penney

Research outputs 2022 to 2026

Politics and pragmatics are central and inseparable features of curriculum reform. In a federated system like Australia, many individuals and organisations are invested in reform at the national and jurisdictional level. This paper focuses on the policy work and roles of key actors positioned at the interface of national and state-based curriculum development, and at the juncture of curriculum policy and pedagogic practice. These were individuals formally identified as ‘curriculum leaders’ in the enactment of the Australian Curriculum in Health and Physical Education (ACHPE). The paper centres on data collected from eight (n = 8) curriculum leaders via semi-structured interviews. …

Investigating The Perspectives Of Older Adults In Residential Aged Care On Oral Health-Related Quality Of Life, Parisa Malekpour, Amanda Devine, Julie Dare, Leesa Costello

Research outputs 2022 to 2026

Objective

The objective of the study was to explore how older people living in a residential aged care facility perceived that their oral health influenced their food preferences and attitudes towards food, their social interactions and their self-esteem.

Background

Poor oral health can have biological, behavioural and social impacts on quality of life among older adults (aged 65+ years). In terms of biological impacts, oral health impairments may cause older adults to avoid many types of foods. This shift in dietary pattern can lead to malnutrition among older people, undermine general health and negatively impact quality of life (QOL).

Materials …

Public Procurement For Innovation Through Supplier Firms' Sustainability Lens: A Systematic Review And Research Agenda, Peter Adjei-Bamfo, Hadrian Geri Djajadikerta, Ferry Jie, Kerry Brown, Reza Kiani Mavi

Research outputs 2022 to 2026

Public sector purchasing processes are gaining increasing prominence as a demand-side innovation tool for addressing national sustainability challenges. Accordingly, there has been growing research attention to this topic. Prior studies suggest three key rationales that underlie the use of public sector procurement to drive innovation: (i) the buyer–user rationale (for creating new needs); (ii) the market/system failure rationale (for improving suppliers' capacity to innovate); and (iii) the public services rationale (for improving public services). However, operational activities at the upstream supply chain affecting the sustainable innovation capacities of supplier firms appear to be under-researched in the public procurement for innovation …

Covid-19 Return To Sport: Collegiate Baseball Injury Prevalence Analysis, Troy B. Puga, Joshua Schafer, Grace Thiel, Laura Ramaker, Tejas Patel, Kevin Treffer

Faculty and Staff Publications

In the spring of 2020, the COVID-19 pandemic rapidly brought college baseball to a halt. Most college baseball players saw disruption of their training and development due to interruptions of their seasons. With these interruptions, it is necessary to examine the effects of the COVID-19 pandemic on collegiate baseball injury epidemiology. Data from a small-school Midwest collegiate conference was tallied for the number of collegiate conference injuries per year, and for the injuries per anatomic region. An unpaired t-test was conducted upon the overall conference mean injuries per year and on each anatomic region for the mean injuries per region …

Spectral Sequences And Khovanov Homology, Zachary J. Winkeler

Dartmouth College Ph.D Dissertations

In this thesis, we will focus on two main topics; the common thread between both will be the existence of spectral sequences relating Khovanov homology to other knot invariants. Our first topic is an invariant MKh(L) for links in thickened disks with multiple punctures. This invariant is different from but inspired by both the Asaeda-Pryzytycki-Sikora (APS) homology and its specialization to links in the solid torus. Our theory will be constructed from a Z^n-filtration on the Khovanov complex, and as a result we will get various spectral sequences relating MKh(L) to Kh(L), AKh(L), and APS(L). Our …

Role Of Peripheral Contacts In Structure And Function Of C-Type Cytochromes, Dong Woo Shin

Dartmouth College Ph.D Dissertations

Structural perturbations influence many properties of proteins, but sequence variations are frequently observed in nature without perturbing the overall stability, fold, and function. In this thesis work, heme proteins cytochrome c and c₂ have been used to provide insight into the relationship between peripheral contacts and its function.

Recent studies with pathogenic cytochrome c mutations G41S and Y48H, and growth-inhibiting mutation K72A, have highlighted the importance of contacts between loops C and D in function of the protein. Characterization of these variants shows that loop D local stability and dynamics are altered upon loop C perturbation, influencing electron transfer, …

Identifying Spatial Heterogeneity In And Potential Biological Consequences Of River Thermal Environments, Keith Jeffrey Fritschie

Dartmouth College Ph.D Dissertations

Temperature is a nearly ubiquitous driver of ecological and evolutionary processes, especially for organisms whose body temperature changes with the environment. The overarching biological importance of environmental temperature and increased availability of temperature datasets have led to its inclusion in spatially continuous models of species’ performance, abundance, and distribution. However, variation in both environmental temperature and animal behavior at finer scales than captured by these models may reduce the accuracy of their scientific conclusions and conservation recommendations. Here I contribute to an improved understanding of thermal variability in river systems and its potential biological consequences for an iconic coldwater species, …

Accelerated Forgetting In People With Epilepsy: Pathologic Memory Loss, Its Neural Basis, And Potential Therapies, Sarah Ashley Steimel Phd

Dartmouth College Ph.D Dissertations

While forgetting is vital to human functioning, delineating between normative and disordered forgetting can become incredibly complex. This thesis characterizes a pathologic form of forgetting in epilepsy, identifies a neural basis, and investigates the potential of stimulation as a therapeutic tool. Chapter 2 presents a behavioral characterization of the time course of Accelerated Long-Term Forgetting (ALF) in people with epilepsy (PWE). This chapter shows evidence of ALF on a shorter time scale than previous studies, with a differential impact on recall and recognition. Chapter 3 builds upon the work in Chapter 2 by extending ALF time points and investigating the …

Advanced Tools For Time-Resolved Imaging Of Tissue Metabolism, Arthur Petusseau

Dartmouth College Ph.D Dissertations

Medical imaging is a crucial tool in diagnosing and treating diseases, and by far the most common set of tools used for point-of-care guidance between a physician and patient are optical devices. For example, visible light imaging has unique applications in endoscopy, dermatology, microscopy, and this range of devices utilize a wide range of optical signals for sensing the tissue. Fluorescence imaging has become a niche but growing methodology in medical diagnostics and treatment because of its simplicity and the ability to integrate reporter molecules, that can reveal detailed information about cellular structures, metabolism, signaling, and other biomolecular features of …

Inhibition Of Cal Pdz Domain Via Non-Canonical And Allosteric Interactions Reveals New Targeting Sites And Strategies, Nicholas Paul Gill

Dartmouth College Ph.D Dissertations

Significant therapeutic achievements have been made in the past decade towards increasing the pool of correctly folded F508del-CFTR and enhancing its activity at the apical membrane. Despite this success, there are still no FDA-approved therapeutics that directly target the post-endocytic stability of F508del-CFTR. Upon internalization, it is rapidly degraded through binding the CFTR-associated ligand (CAL) PDZ domain (CALP), which triggers its degradation in the lysosome. Our group and others have shown that inhibiting CAL increases the half-life of functional F508del-CFTR at the cell‑membrane and significantly enhances ion transport, suggesting that ‘stabilizer’ compounds, especially in conjunction with current CF therapeutics, would …

Design Of Next-Generation Neural Interfaces For Decoding The Brain, Yi Qiang

Dartmouth College Ph.D Dissertations

The primary goal of neural interface technology is to establish a connection between the nervous system and the external world by recording and modulating neural signals. Over the past few decades, microelectrode array (MEA) technology has played an essential role in the acquisition of electrophysiological signals, with impressive progress being made towards developing high-density, large-throughput, and ultra-flexible MEAs. However, despite these advancements, there remain long-standing limitations in current neural interfaces. For example, electrophysiology is limited in its ability to distinguish cell types and has limited spatial resolution due to its electrical recording nature. Furthermore, conventional neural MEAs are limited to …

Combating Fake News: A Gravity Well Simulation To Model Echo Chamber Formation In Social Media, Jeremy E. Thompson

Dartmouth College Ph.D Dissertations

Fake news has become a serious concern as distributing misinformation has become easier and more impactful. A solution is critically required. One solution is to ban fake news, but that approach could create more problems than it solves, and would also be problematic from the beginning, as it must first be identified to be banned. We initially propose a method to automatically recognize suspected fake news, and to provide news consumers with more information as to its veracity. We suggest that fake news is comprised of two components: premises and misleading content. Fake news can be condensed down to a …

Mitochondrial Division: Synergizing In Mitochondrial Divisome, Ao Liu

Dartmouth College Ph.D Dissertations

Mitochondria are the energy factories of the cell. The dynamic nature of cells demands routine changes in mitochondrial morphology by fusion and division. The dynamin GTPase Drp1 is a central mitochondrial division protein, driving constriction of the outer mitochondrial membrane via oligomerization. At least four regulatory factors control Drp1 activity on the outer mitochondrial membrane (OMM): 1) receptor proteins (Mff, MiD49, MiD51, and Fis1); 2) actin filaments; 3) the mitochondrial phospholipid cardiolipin (CL); and 4) Drp1 post-translational modifications, of which two phosphorylation sites (S579 and S600) are the most well studied. However, the molecular mechanism of how these factors work …

Utilizing Ground-Penetrating Radar To Estimate The Spatial Distribution Of Snow Depth Over Lake Ice In Canada’S Sub-Arctic, Alicia Pouw

Theses and Dissertations (Comprehensive)

With the expected rise in air temperature, it becomes important to understand how snow will respond in different climate scenarios. The presence of snow over lake ice largely influences the ice thickness, and as Canada’s Arctic and sub-arctic regions are experiencing warming at twice the global rate, concerns rise as changes in the snowpack will significantly impact northern communities that rely on lake ice as a means of transportation, source for drinking water, and feeding their families. The distribution of snow depth is highly sensitive to changes in climate over time, as such a slight increase in air temperature or …

Contrasting Seasonal Cycling Of Arsenic In A Series Of Subarctic Shield Lakes With Different Morphometric Properties, Jeremy Harbinson

Theses and Dissertations (Comprehensive)

The subarctic shield near Yellowknife, Northwest Territories (NWT), is populated with thousands of small lakes (<1.5 km²) and several large lakes. Historic mining activities in the region have left a legacy of environmental impacts and widespread arsenic (As) contamination in both aquatic and terrestrial environments. In particular, several small subarctic lakes near Yellowknife have been previously documented to be contaminated with high levels of As. Subarctic lakes are characterized by seasonal ice-cover that can persist for more than half of the year, yet little is known about the under-ice spatial and seasonal dynamics of As cycling. The objective of …

Dynamical Aspects In (4+1)-Body Problems, Ryan Gauthier

Theses and Dissertations (Comprehensive)

The n-body problem models a system of n-point masses that attract each other via some binary interaction. The (n + 1)-body problem assumes that one of the masses is located at the origin of the coordinate system. For example, an (n+1)-body problem is an ideal model for Saturn, seen as the central mass, and one of its outer rings. A relative equilibrium (RE) is a special solution of the (n+1)-body problem where the non-central bodies rotate rigidly about the centre of mass. In rotating coordinates, these solutions become equilibria.

In this thesis we study dynamical aspects of planar (4 + …

Best Practices For Social Workers Engaging With Spiritual/Religious Clients, Stewart J. Smith Mr.

Theses and Dissertations (Comprehensive)

This research examined what Canadian social workers should consider when engaging therapeutically with clients for whom spirituality/religion is of central importance. There are several challenges in examining this issue in Canada (the north section of Turtle Island). One is the oppression of Indigenous peoples’ spirituality by colonizers imposing various Christian denominational spiritual/religious views. There has also been a trend of Christian practice declining in church worship among settler people, although Christianity remains part of the dominant cultural norms. Like many of the helping professions, social work has little to no education/training related to spirituality/religion and clinical work. This move away …

Collision Avoidance Strategies Of Middle-Aged Children And Young Adults In A Virtual Environment, Megan Hammill

Theses and Dissertations (Comprehensive)

The ability to perceive and react to visual information is critical for avoiding a collision with an approaching obstacle. The perception-action system undergoes a prolonged period of development and as a result, children make more last-minute locomotor adjustments than adults when avoiding stationary obstacles. The purpose of this thesis was to compare the avoidance behaviours of middle-aged children (10-12 years old) to young adults (YA) during a head-on collision course with an approaching virtual pedestrian (VP). Children (N=16, 10.8 0.75 years; 8 males) and YA (N=16, 22.94 2.08 years; 7 males) were immersed in a virtual environment using the HTC …

Experiences Of Quality Of Life Among Youth Experiencing Homelessness, Mental Health Problems, And Addictions, Wilsy Choudhary

Theses and Dissertations (Comprehensive)

Youth experiencing homelessness are often at a higher risk for developing concurrent mental health and addiction disorders. Existing interventions such as Housing First for Youth (H4FY) aim to provide youth experiencing homelessness with immediate access to safe, affordable housing as well as social inclusion and wellness supports. Furthermore, mental health interventions in the form of an integrated mental health and addictions (IMHA) service model have also been proposed to address the access barriers in place for youth experiencing homelessness, such as arbitrary exclusion criteria for substance use, long waiting periods and to further help them navigate the existing complex mental …

(Re)Mediating History In Canadian Auto/Biographic Long Poems Since 1970, Heather Olaveson

Theses and Dissertations (Comprehensive)

Responding to current topics of national debate around cultural appropriation, authenticity of voice and identity, historical commemoration, and foundational systems of social injustice, this dissertation takes as its launching point the question of how we are implicated in each other's histories. It examines the politics of rewriting history in Canadian auto/biographic long poems from 1970 to the present, reconsidering historiography as it intersects with life writing, gender, race, and the performance of voice. What narratives are reimagined about the lives of Canadian historical figures, how are such stories articulated, and who is permitted to perform the telling? As a whole, …

Nitrogen: Both A Potential Stimulator And Suppressor Of Cyanobacterial Blooms In Temperate Lakes, Catherine Goltz

Theses and Dissertations (Comprehensive)

Cyanobacterial blooms are complex phenomenon that are impacted and controlled by various factors such as lake depth, air temperature, wind, and nutrient loading. Nutrients such as phosphorus, nitrogen and iron all have very differing effects on cyanobacterial blooms. While phosphorus and iron are known to drive cyanobacterial biomass, nitrogen has been observed to have a direct impact on toxin synthesis. Nitrogen exists in the environment in many different forms such as atmospheric N₂, in inorganic forms such as nitrate and ammonium as well as in organic forms such as urea which can all affect cyanobacterial bloom development differently. …

Phosphorus Release And Recovery From Simulated Ferric Wastewater Sludge, Aseel Alnimer

Theses and Dissertations (Comprehensive)

Phosphorus (P) is a fundamental element necessary for all life forms and a key component in the fertilizer industry. Meanwhile, the excessive load of P to water bodies due to human activities has the potential to promote eutrophication. Wastewater treatment plants remove P either biologically or chemically and produce P rich sludge which could be a potential renewable source for P. At present, commercial technologies exist for P recovery from biological wastewater sludge. However, P recovery from chemical sludge particularly iron(III)-phosphate (Fe-P) sludge generated in chemical P removal plants that use iron(III) salts remains a challenge.

This study explored, in …

Identification Of A Dna Polymerase Alpha Gene Sequence In Thermomyces Lanuginosus Fungus, Nathan Williams

Honors Program Theses

With cell growth being the main focus of our research, we chose to study DNA polymerase alpha. DNA polymerase alpha is likely to be involved in cell growth as it is the enzyme that starts DNA replication. Control of this enzyme might lead to decreased cell growth in cancer or increased cell growth in damaged spinal cord tissue. We chose the thermophilic fungus Thermomyces lanuginosus for the study of the enzyme due to the ability to compare the enzyme’s activity during fungal growth at different temperatures. Thermomyces exhibits rapid growth at high temperatures and slow growth at low temperatures. Studying …

The Sacrifice Of Artistry For A Convenient Society, Riley Jermier

Honors Program Theses

Over the past hundred or so years, the music industry has seen lots of change in the way that music is made, played, and displayed. With the advancement of recording technology, societal influence, and musicianship we see a plethora of different genres, as well as mediums of listening in today's world. This thesis discusses the different modes of recording, from LP to streaming services, and comments on the sonic characteristics of numerous recordings from different genres and eras. This thesis also compares and contrasts certain aspects of professional level audio and consumer level audio, as well as sonic biases in …

How Online Discourse Networks Fields Of Practice: The Discursive Negotiation Of Autonomy On Art Organisation About Pages, Tommie Soro

Articles

This article examines how the online discourse of art organisations forges relationships between the artworld and the fields of politics and economy. Combining elements of Pierre Bourdieu’s field analysis and Norman Fairclough’s critical discourse analysis, the article analyses an elite art magazine, e-flux, and an elite art museum, IMMA, and the activities of discourses, genres, and utterances on their about pages. Its results suggest that the about pages of these organisations forge links between the artworld and the fields of politics and economy by mobilising discourse in these fields and by incorporating discourse practices from these fields. The ideological tension …

Editorial: Investigating The Effect Of The Physical Context On Customer Experience, Helen L. Bruce, Ewa Krolikowska, Tara Rooney

Articles

This editorial introduces a special issue of the Journal of Services Marketing, dedicated to articles discussing the effect of the physical context on customer experience. The editorial identifies diverse areas of extant knowledge which researchers might draw upon when investigating the effect of the physical context on customer experience. to inform future research agendas.