Digital Commons Network^™

Innovations In Hematopoietic Stem-Cell Mobilization: A Review Of The Novel Cxcr4 Inhibitor Motixafortide, Zachary D. Crees, Michael P. Rettig, John F. Dipersio

2020-Current year OA Pubs

Hematopoietic stem-cell transplantation (HCT) and stem-cell-based gene therapies rely on the ability to collect sufficient CD34+ hematopoietic stem and progenitor cells (HSPCs), typically

Diastolic Dysfunction Criteria And Heart Failure Readmission In Patients With Heart Failure And Reduced Ejection Fraction, Steven J. Lavine, Danielle Kelvas

2020-Current year OA Pubs

No abstract provided.

Agreement Between Lea Symbols And Patti Pics Visual Acuity In Children And Adults, Arjun Sapkotaa, Sanjeeta Sitaula, Gauri Shankar Shresthab, Niraj Dev Joshib, Bipin Koiralaa Bipin Koiralaa, Nabin Paudel

Articles

Patti Pics (PP) and Lea Symbols (LS) are commonly used by eye care practitioners worldwide. Although the relationship between the two tests is fairly well understood, the availability of different chart designs (single optotypes, multiple optotypes, multiple optotypes with crowding box) merits futher understanding. The purpose of this study is to explore the agreement between the acuity measures obtained with Patti Pics and Lea Symbols in children and adults and compare their performance with the Sloan Letter (SL) chart in adults. Methods: Monocular visual acuity was obtained from ninety-three 3 to 5-year-old children using Patti Pics and Lea Symbols. Acuities …

Choroidal Thickness Profiles And Associated Factors In Myopic Children, Emmnuel Kobia Acquah, Daniel Ian Flitcroft, Gareth Lingham, Nabin Paudel, James Loughman

Articles

SIGNIFICANCE: This study addresses the lack of choroidal thickness (ChT) profile information available in European children and provides a baseline for further evaluation of longitudinal changes in ChT profiles in myopic children as a potential biomarker for myopia treatment and identifying children at risk of myopic progression.

PURPOSE: This study aimed to investigate ChT profiles and associated factors in myopic children.

METHODS: Baseline data of 250 myopic children aged 6 to 16 years in the Myopia Outcome Study of Atropine in Children clinical trial were analyzed. Choroidal thickness images were obtained using swept-source optical coherence tomography (DRI-OCT Triton Plus; Topcon …

Distribution Of Axial Length In Australians Of Different Age Groups, Ethnicities, And Refractive Errors, Vinay Kumar Nilagiri, Samantha Sze-Yee Lee, Gareth Lingham, Jason Charng, Seyhan Yazar, Alex W. Hewitt, Lynn R. Griffiths, Paul G. Sanfilippo, Tzu-Hsun Tsai, David A. Mackey

Articles

Treatments are available to slow myopic axial elongation. Understanding normal axial length (AL) distributions will assist clinicians in choosing appropriate treatment for myopia. We report the distribution of AL in Australians of different age groups and refractive errors.

Holographic Recording Of Unslanted Volume Transmission Gratings In Acrylamide/Propargyl Acrylate Hydrogel Layers: Towards Nucleic Acids Biosensing, Paola Zezza, María Isabel Lucío, Izabela Naydenova, María José Bañuls, Ángel Maquieira

Articles

The role of volume hydrogel holographic gratings as optical transducers in sensor devices for point-of-care applications is increasing due to their ability to be functionalized for achieving enhanced selectivity. The first step in the development of these transducers is the optimization of the holographic recording process. The optimization aims at achieving gratings with reproducible diffraction efficiency, which remains stable after reiterative washings, typically required when working with analytes of a biological nature or several step tests. The recording process of volume phase transmission gratings within Acrylamide/Propargyl Acrylate hydrogel layers reported in this work was successfully performed, and the obtained diffraction …

Cover And Contents

Turkish Journal of Physics

No abstract provided.

ℼ± -,ℼ0-Meson Electroweak Decays Within Relativistic Quark Model Based On Point Form Of Poincaré-Invariant Quantum Mechanics, Vadzim Haurysh, Viktor Andreev

Turkish Journal of Physics

In the course of work the integral representation of ℼ⁰-meson form-factor of ℼ⁰ → γγ process has been obtained within relativistic quark model based on point form of Poincaré-invariant quantum mechanics taking into account anomalous magnetic moments of κ_υ and κ_ⅾ quarks. The parameters obtained using pseudoscalar density constant g_ℼ± , current masses of υ- and ⅾ-quarks as well as decay constant ℼ^± → ℓ^±_νℓ were used for numerical modeling of F_ℼ0γ(t) form-factor in time-like region. Similar calculations for ℼ⁰ → γγ decay characteristics with reference to quark …

Magnetic Response Of A Two-Dimensional Viscous Electron Fluid, Aydin Cem Keser, Oleg Sushkov

Turkish Journal of Physics

It has been established that the Coulomb interactions can transform the electron gas into a viscous fluid. This fluid is realized in a number of platforms, including graphene and two-dimensional semiconductor heterostructures. The defining characteristic of the electron fluid is the formation of layers of charge carriers that are in local thermodynamic equilibrium, as in classical fluids. In the presence of nonuniformities, whirlpools and nontrivial flow profiles are formed, which have been directly imaged in recent experiments. In this paper, we theoretically study the response of the electron fluid to localized magnetic fields. We find that the electric current is …

Cover And Contents

Turkish Journal of Physics

No abstract provided.

Sensing Translocating Polymers Via Induced Magnetic Fields, Şahi̇n Büyükdağli

Turkish Journal of Physics

The requirement to boost the resolution of nanopore-based biosequencing devices necessitates the integration of novel biosensing techniques with reduced sensitivity to background noise. In this article, we probe the signatures of translocating polymers in magnetic fields induced by ionic currents through membrane nanopores. Within the framework of a previously introduced charge transport theory, we evaluate the magnetic field signals generated by voltage- and pressure-driven DNA translocation events in monovalent salt solutions. Our formalism reveals that in voltage-driven transport, the translocating polymer suppresses the induced magnetic field via the steric blockage of the ion current through the midpore. In the case …

Exploring The High Energy Frontiers Of The Milky Way With Ground-Based Gamma-Ray Astronomy: Pevatrons And The Quest For The Origin Of Galactic Cosmic-Rays, Ekrem Oğuzhan Angüner

Turkish Journal of Physics

Cosmic rays (CRs) are charged particles that arrive at Earth isotropically from all directions and interact with the atmosphere. The presence of a spectral knee feature seen in the CR spectrum at 3 PeV energies is an evidence that astrophysical objects within our Galaxy, which are known as 'Galactic PeVatrons', are capable of accelerating particles to PeV energies. Scientists have been trying to identify the origin of Galactic CRs and have been looking for signatures of Galactic PeVatrons through neutral messengers. Recent advancements in ground-based γ-ray astronomy have led to the discovery of 12 Galactic sources emitting above 100 TeV …

Probing Exotic Neutral Current Interactions With Coherent Elastic Neutrino-Nucleus Scattering, Mehmet Demi̇rci̇

Turkish Journal of Physics

The Exotic Neutral Current introduces new interactions beyond standard model (BSM) which consist of all possible four-fermion nonderivative Lorentz structures: scalar (S), pseudoscalar (P), vector (V), axial-vector (A), and tensor (T). In this work, we investigate the prediction of this model via the Coherent Elastic Neutrino-Nucleus Scattering (CE$\nu$NS). The differential cross-section spectrum of CE$\nu$NS for three nuclei in regards to experiment advancement are calculated in the framework of this model independent proposal using recent obtained bound. We present the ratio of this exotic model with the SM for various threshold energies. Significant bound is shown lie in the lower threshold …

Shortterm Optical Variability Of 4c 29.45, Aykut Özdönmez

Turkish Journal of Physics

We observed the flat-spectrum radio quasar 4C 29.45 in the BVRI optical bands for 39 nights from February 2022 to July 2022 with the T60 telescope at TÜBİTAK National Observatory (TUG) in Turkey. In this study, we aimed to study flux, color, and spectral variability on short timescales. The object was in an active (bright) phase with an average optical R-band brightness of 14.7 mag and was variable in the BVRI bands throughout the monitoring period. We analyzed the flux variability during our observation period, and the variability amplitudes in V, R, and I bands were determined to be 220%, …

Analyzes Of Algebraic Classification Of Higher Dimensional Kundt Geometries With Large D Method, Pinar Ki̇rezli̇

Turkish Journal of Physics

In this paper, classification of higher dimensional Kundt geometry is revisited as the dimension of the spacetime D→∞ . In addition to previous studies, in order to Kundt geometry becomes algebraically special spacetime obligatory conditions are determined. Additionally, Type II, Type III, Type N, Type O and Type D Kundt geometries are explicitly analyzed. Classification of several metrics such as pp-waves, non-gyratonic Kundt metric and VSI spacetime, which are well-known subclasses of Kundt geometry are studied.

Gold Thin-Film Based Narrow-Band Perfect Absorbers For Near-Ir Frequencies, Serap Aksu

Turkish Journal of Physics

Perfect absorbers have received significant attention due to their tunable and extraordinary absorptive behaviour of light at selected wavelenghts. Such absorption can be achieved by the means of nanostructured materials with various types of flexibility. Despite these advantages nanofabrication is a challenging process. In this study, we manufacture and characterize a gold thin-film based ultra narrow-band perfects absorber that does not require nanostructures for full absorption of the incident light. Perfect absorption is based on Fabry-Perot interference created using a metal-insulator-metal triple layer. The fabrication involves precise deposition of a gold film (35 nm) and silicon nitride dielectric film (110-170 …

Improving The Angular Visibility Of Photopolymer-Based Reflection Holograms For Sensing Applications, Tatsiana Mikulchyk, Kevin Murphy, John Walsh, Suzanne Martin, Dervil Cody, Izabela Naydenova

Articles

Volume reflection hologram-based sensors are designed to visibly change colour in response to a target stressor or analyte. However, reflection holograms fabricated in thick photopolymer films are highly angularly selective, making these sensors challenging to view and interpret by non-experts. Here, the use of speckle holography to improve the visibility of reflection holograms is presented. A novel recording approach combining speckle recording techniques with Denisyuk reflection recording geometry is described. The recorded speckle reflection grating operates as a series of multiplexed reflection gratings with a range of spatial frequencies, capable of reflecting light at a wider range of angles. A …

Development And Evaluation Of A Multifrequency Ultrafast Doppler Spectral Analysis (Mfudsa) Algorithm For Wall Shear Stress Measurement: A Simulation And In Vitro Study, Andrew Malone, Sean Cournane, Izabela Naydenova, James F. Meaney, Andrew J. Fagan, Jacinta Browne

Articles

Cardiovascular pathology is the leading cause of death and disability in the Western world, and current diagnostic testing usually evaluates the anatomy of the vessel to determine if the vessel contains blockages and plaques. However, there is a growing school of thought that other measures, such as wall shear stress, provide more useful information for earlier diagnosis and prediction of atherosclerotic related disease compared to pulsed-wave Doppler ultrasound, magnetic resonance angiography, or computed tomography angiography. A novel algorithm for quantifying wall shear stress (WSS) in atherosclerotic plaque using diagnostic ultrasound imaging, called Multifrequency ultrafast Doppler spectral analysis (MFUDSA), is presented. …

Color-Changing Reflection Hologram For Quality Assurance Of Therapeutic Ultrasound Systems, Tatsiana Mikulchyk, John Walsh, Jacinta Browne, Izabela Naydenova, Dervil Cody

Articles

The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A hologram, consisting of a reflection grating fabricated in an acrylate photopolymer film, has been developed to produce an immediate, visible, and permanent change in the color of the reconstructed hologram from red to green in response to incident ultrasound energy. The influence of the therapeutic ultrasound insonation parameters (exposure time, ultrasound power density, and proximity to the point …

Probe–Integrated Electrochemical Sensing Platform For Measuring Trace Levels Of Parathion Pesticides Residues In Water Using Au- Nanoparticles Anchored Nafion Nano Composite Modified Glassy Carbon Electrode, H. Alwael, S.H. Al-Sedran, Mohamed Oubaha, N.A.A. Asiri, A.S. Bashammakh, A.S. Alharthy, N.A. Albassami, T.N. Abduljabbar, G.I. Mohamed, H.M. Nassef, E.A. Bahaidarah, B.G. Alhogbi, M.S. El-Shahawi

Articles

Nanomaterial represents a principal driver to the adoption of electrochemical sensors for pesticides residues in water. Thus, the current strategy reports facile and highly sensitive electrochemical probe for monitoring parathion residues in water. The probe was based upon the use of Au nanoparticles (AuNPs) functionalized Nafion nanocomposites modified glassy carbon electrode (Au NPs/Nafion/GCE). The surface morphology, effective surface area and electrocatalytic performance of the Au NPs/Nafion/GCE were recorded and assigned using a scanning electron microscopy (SEM), cyclic voltammetry (CV) and electronic spectra. A straightforward protocol based upon combination of Au NPs/Nafion/GCE and square wave- adsorptive cathodic stripping voltammetry at pH …

Prevalence Of Refractive Errors In Nepalese Children And Adults: A Systematic Review With Meta-Analysis, Jeewanand Bist, Himal Kandel, Nabin Paudel, Dinesh Kaphled, Rajendra Gyawali, Sanjay Marasini, Rabindra Adhikaryg, Prakash Paudel

Articles

Clinical relevance: Country-specific estimates of the prevalence of refractive errors are important to formulate national eye health policies for refractive care services. Background: The purpose of this study was to systematically synthesise available literature and estimate the prevalence of refractive errors in the Nepalese population. Methods: PubMed, Scopus, and Web of Science databases were systematically searched for articles on refractive errors and presbyopia published in English language until 27 September 2022. Population and school-based quantitative, cross-sectional prevalence studies and Rapid Assessment of Avoidable Blindness survey repository data were included. The quality of the included studies was assessed using the Newcastle …

Tfos Lifestyle - Evidence Quality Report: Advancing The Evaluation And Synthesis Of Research Evidence, Laura E. Downie, Alexis Ceecee Britten-Jones, Ruth E. Hogg, Isabelle Jalbert, Tianjing Li, Gareth Lingham, Su-Hsun Liu, Riaz Quereshi, Ian J. Saldanha, Sumeer Singh, Jennifer P. Craig

Articles

Evidence-based practice is a dominant paradigm in healthcare that emphasizes the importance of ensuring the translation of the best available, relevant research evidence into practice. An Evidence Quality Subcommittee was established to provide specialized methodological support and expertise to promote rigorous and evidence-based approaches for the Tear Film and Ocular Surface Society (TFOS) Lifestyle Epidemic reports. The present report describes the purpose, scope, and activity of the Evidence Quality Subcommittee in the undertaking of high-quality narrative-style literature reviews, and leading prospectively registered, reliable systematic reviews of high priority research questions, using standardized methods for each topic area report. Identification of …

Tfos Lifestyle: Impact Of The Digital Environment On The Ocular Surface, James S. Wolffsohn, Gareth Lingham, Laura E. Downie, Bykie Huntjens, Takenori Inomata, Saleel Jivraj, Emmanuel Kobia-Acquah, Alex Muntz, Karim Mohamed-Noriega, Sotiris Plainis, Michael Read, Rony R. Sayegh, Sumeer Singh, Tor P. Utheim, Jennifer P. Craig

Articles

Eye strain when performing tasks reliant on a digital environment can cause discomfort, affecting productivity and quality of life. Digital eye strain (the preferred terminology) was defined as “the development or exacerbation of recurrent ocular symptoms and/or signs related specifically to digital device screen viewing”. Digital eye strain prevalence of up to 97% has been reported, due to no previously agreed definition/diagnostic criteria and limitations of current questionnaires which fail to differentiate such symptoms from those arising from nondigital tasks. Objective signs such as blink rate or critical flicker frequency changes are not ‘diagnostic’ of digital eye strain nor validated …

Subfoveal Choroidal Imaging In High Myopic Nepalese Cohort, Parash Gyawali, Ashutosh Jnawali, Anish Kharal, Manish Subedi, Sandeep Kandel, Prajjol Raj Puri, Nabin Paudel

Articles

Current image captioning models produce fluent captions, but they rely on a one-size-fits-all approach that does not take into account the preferences of individual end-users. We present a method to generate descriptions with an adjustable amount of content that can be set at inference-time, thus providing a step toward a more user centered approach to image captioning.

Systematic Review Of Clinical Practice Guidelines For Uveitis, Nima Ghadiri, Ian R. Reekie, Iris Gordon, Sare Safi, Gareth Lingham, Jennifer R. Evans, Stuart Keel

Articles

To facilitate the integration of eye care into universal health coverage, the WHO is developing a Package of Eye Care Interventions (PECI). Development of the PECI involves the identification of evidence-based interventions from relevant clinical practice guidelines (CPGs) for uveitis.

A systematic review of CPGs published on uveitis between 2010 and March 2020 was conducted. CPGs passing title and abstract and full-text screening were evaluated using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and data on recommended interventions extracted using a standard data extraction sheet.

Effects Of Flexibility In Coarse-Grained Models For Bovine Serum Albumin And Immunoglobulin G, Frank Hirschmann, Hender Lopez, Felix Roosen-Runge, Tilo Seydel, Frank Schreiber, Martin Oettel

Articles

We construct a coarse-grained, structure-based, low-resolution, 6-bead flexible model of bovine serum albumin (BSA, PDB: 4F5S), which is a popular example of a globular protein in biophysical research. The model is obtained via direct Boltzmann inversion using all-atom simulations of a single molecule, and its particular form is selected from a large pool of 6-bead coarse-grained models using two suitable metrics that quantify the agreement in the distribution of collective coordinates between all-atom and coarse-grained Brownian dynamics simulations of solutions in the dilute limit. For immunoglobulin G (IgG), a similar structure-based 12-bead model has been introduced in the literature [Chaudhri …

Effect Of Pre-Analytical Variables On Raman And Ftir Spectral Content Of Lymphocytes, Jade F. Monaghan, Daniel Cullen, Claire Wynne, Fiona Lyng, Aidan Meade

Articles

The use of Fourier transform infrared (FTIR) and Raman spectroscopy (RS) for the analysis of lymphocytes in clinical applications is increasing in the field of biomedicine. The pre-analytical phase, which is the most vulnerable stage of the testing process, is where most errors and sample variance occur; however, it is unclear how pre-analytical variables affect the FTIR and Raman spectra of lymphocytes. In this study, we evaluated how pre-analytical procedures undertaken before spectroscopic analysis influence the spectral integrity of lymphocytes purified from the peripheral blood of male volunteers (n = 3). Pre-analytical variables investigated were associated with (i) sample preparation, …

Review Of Recent Advances In Photosensitive Polymer Materials And Requirements For Transmission Diffractive Optical Elements For Led Light Sources, Michael Murray, Izabela Naydenova, Suzanne Martin

Articles

Scattered light from outdoor LED sources is a major contributor to blue-spectrum light pollution which negatively impacts ecology and public health. Volume holographic diffractive optical elements (DOEs), made with low-cost photosensitive polymers, are proposed as a technological solution that can minimise this scattering. This review examines requirements needed for efficient operation of transmission-format DOEs with LEDs and implications for material choices. For such DOEs to have a single diffraction order and high efficiency there is a corresponding range of acceptable Δn. A survey of materials also found that many current materials satisfy the Δn requirements for single-element DOEs. It is …

The Association Of Adolescents' Smoking With The Physical Activity Levels Of Their Friends, R.A. Smit, M.A.G. Kuipers, B. Federico, Luke Clancy, J. Perlman, A.D. Rozema, A.E. Kunst

Articles

Background: Smoking is inversely related to people's Physical Activity Level (PAL). As the behavior of friends may affect the choices and behavior of adolescents, having friends with a high PAL may potentially protect against adolescent smoking. This study aims to assess whether adolescents' smoking is associated with the PAL of their friends. Methods: SILNE-R survey data of 11.918 adolescents from 55 different schools in 7 European cities was used to determine weekly smoking, individual PAL, PAL of friends, school PAL, and smoking of friends. Multilevel, multivariable logistic regression analysis were used to assess the association between the PAL of friends …

The Effectiveness Of Allen Carr's Method For Smoking Cessation: A Systematic Review, Irene Possenti, Marco Scala, Alessandra Lugo, Luke Clancy, Sheila Keogan, Silvano Gallus

Articles

Introduction: Allen Carr's (AC) method is a pharmacotherapy-free approach to quit smoking that is delivered through seminars, online courses, or in the form of a book. It has gained popularity, but its effectiveness remains controversial due to a lack of scientific evidence. This systematic review aims to provide an updated overview of the current evidence on the effectiveness of the AC method.

Methods: We conducted a systematic literature review of all epidemiological studies evaluating the effectiveness of the AC method for smoking cessation, published in PubMed/MEDLINE and Embase up to March 2023.

Results: Among 34 original studies identified through the …