Digital Commons Network^™

Editorial: Non-Coding Genome And Endocrinology: From Bench To Bedside, Radu Pirlog, Kinga Nemeth, George Adrian Calin

Faculty, Staff and Student Publications

No abstract provided.

Lysosomal Tmem9-Lamtor4-Controlled Mtor Signaling Integrity Is Required For Mammary Tumorigenesis, Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M Lien, Junjie Chen, Jae-Il Park

Faculty, Staff and Student Publications

No abstract provided.

Severe Radiation-Induced Lymphopenia During Concurrent Chemoradiotherapy For Stage Iii Non-Small Cell Lung Cancer: External Validation Of Two Prediction Models, Peter S N Van Rossum, Celia Juan-Cruz, Barbara Stam, Maddalena M G Rossi, Steven H Lin, Azadeh Abravan, José S A Belderbos, Jan-Jakob Sonke

Faculty, Staff and Student Publications

BACKGROUND: Severe radiation-induced lymphopenia (RIL) in patients undergoing chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is associated with decreased immunotherapy efficacy and survival. At The Christie and MD Anderson Cancer Center (MDACC), prediction models for lymphopenia were developed in lung and esophageal cancer patients, respectively. The aim of this study was to externally validate both models in patients with stage III NSCLC.

METHODS: Patients who underwent concurrent CRT for stage III NSCLC in 2019-2021 were studied. Outcomes were grade ≥3 and grade 4 lymphopenia during CRT. The Christie model predictors for grade ≥3 lymphopenia included age, baseline lymphocyte count, …

Potential Chemoprotective Effects Of Active Ingredients In Salvia Miltiorrhiza On Doxorubicin-Induced Cardiotoxicity: A Systematic Review Of In Vitro And In Vivo Studies, Qingqing Wang, Jiaxian Li, Xuelei Chu, Xiaochen Jiang, Chuanlong Zhang, Fudong Liu, Xiyuan Zhang, Yi Li, Qian Shen, Bo Pang

Faculty, Staff and Student Publications

BACKGROUND: Recently, attention has been paid to the protective properties of active ingredients in

METHODS: According to the PRISMA guideline, the current systematic review was conducted in the Web of Science, PubMed, Embase, and the Cochrane Library to collect all relevant

RESULTS: Twenty-two eligible articles were included in this systematic review. Eleven types of active ingredients in

CONCLUSION: This systematic review demonstrated that AISM have chemoprotective effects on DIC

Lysosomes, Curcumin, And Anti-Tumor Effects: How Are They Linked?, Qian Shen, Xue Pan, Yi Li, Junchen Li, Chuanlong Zhang, Xiaochen Jiang, Fudong Liu, Bo Pang

Faculty, Staff and Student Publications

Curcumin is a natural active ingredient from traditional Chinese medicine (TCM) that has multi-target characteristics to exert extensive pharmacological activities and thus has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders. As an important class of membranous organelles in the intracellular membrane system, lysosomes are involved in biological processes such as programmed cell death, cell metabolism, and immune regulation, thus affecting tumor initiation and progression. It has been shown that curcumin can modulate lysosomal function through the aforementioned pathways, thereby affecting tumor proliferation, invasion, metastasis, drug resistance, and immune function. …

Pepsim: T-Cell Cross-Reactivity Prediction Via Comparison Of Peptide Sequence And Peptide-Hla Structure, Sarah Hall-Swan, Jared Slone, Mauricio M Rigo, Dinler A Antunes, Gregory Lizée, Lydia E Kavraki

Faculty, Staff and Student Publications

INTRODUCTION: Peptide-HLA class I (pHLA) complexes on the surface of tumor cells can be targeted by cytotoxic T-cells to eliminate tumors, and this is one of the bases for T-cell-based immunotherapies. However, there exist cases where therapeutic T-cells directed towards tumor pHLA complexes may also recognize pHLAs from healthy normal cells. The process where the same T-cell clone recognizes more than one pHLA is referred to as T-cell cross-reactivity and this process is driven mainly by features that make pHLAs similar to each other. T-cell cross-reactivity prediction is critical for designing T-cell-based cancer immunotherapies that are both effective and safe. …

The Cx3cl1-Cx3cr1 Chemokine Axis Can Contribute To Tumor Immune Evasion And Blockade With A Novel Cx3cr1 Monoclonal Antibody Enhances Response To Anti-Pd-1 Immunotherapy, Apoorvi Chaudhri, Xia Bu, Yunfei Wang, Michael Gomez, James A Torchia, Ping Hua, Shao-Hsi Hung, Michael A Davies, Gregory A Lizee, Ulrich Von Andrian, Patrick Hwu, Gordon J Freeman

Faculty, Staff and Student Publications

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration. We generated a novel monoclonal antibody against mouse CX3CR1 that binds to CX3CR1 and blocks the CX3CL1-CX3CR1 interaction. We next explored the immune evasion strategies implemented by the CX3CL1-CX3CR1 axis and find that it initiates a resistance program in cancer cells that results in 1) facilitation of tumor cell migration, 2) secretion of soluble mediators to generate a pro-metastatic niche, 3) secretion of soluble …

Stephen Massey: A Career In Visual Neuroscience, Stephen L Mills, David W Marshak

Faculty, Staff and Student Publications

This review is a memoir by Dr. Stephen C. Massey's longtime collaborator, Dr. Stephen L. Mills, and written, for the most part, in the first person. It also serves as an introduction to the virtual festschrift to celebrate Dr. Massey's retirement. and. The references cited here are only a few of the highlights of Dr. Massey's distinguished career. A complete list is found here: https://pubmed.ncbi.nlm.nih.gov/?term=massey+sc+%28retina+or+photoreceptors%29&sort=date.

Nano-Embedded Medical Devices And Delivery Systems In Interventional Radiology, Erin Marie D San Valentin, Allan John R Barcena, Carleigh Klusman, Benjamin Martin, Marites P Melancon

Faculty, Staff and Student Publications

Nanomaterials research has significantly accelerated the development of the field of vascular and interventional radiology. The incorporation of nanoparticles with unique and functional properties in medical devices and delivery systems has paved the way for the creation of novel diagnostic and therapeutic procedures for various clinical disorders. In this review, we discuss the advancements in the field of interventional radiology and the role of nanotechnology in maximizing the benefits and mitigating the disadvantages of interventional radiology theranostic procedures. Several nanomaterials have been studied to improve the efficacy of interventional radiology interventions, reduce the complications associated with medical devices, improve the …

Parental Effects Of Social Density On Mating Behaviour, Reproductive Success, And Longevity, Shaun Rowlands

School of Biological and Marine Sciences Theses

Organisms can adapt to changing environments, changing their investment strategies to increase their lifetime reproductive success. Contemporary evolutionary theory would suggest that organisms have evolved mechanisms which allow them to assess competition and acquire phenotypic responses that accurately responds to the environment, allowing for rapid changes in response to the social context. Selection would favour organisms which can make nongenetic parental effects, with parents evolving an ability pass on plasticity responses that optimize offspring fitness related traits to suit ecological challenges. In this thesis , I investigate how the social density affects the mating behaviour and offspring production of the …

Ecological And Oceanographic Interactions Of An Offshore Longline Mussel Farm, Llucia Mascorda-Cabre

School of Biological and Marine Sciences Theses

A growing human population coupled with the need to protect marine ecosystems, requires sources of sustainable protein. Finfish aquaculture can produce a wide range of environmental impacts while shellfish aquaculture reports fewer negative effects, being classed a sustainable protein source. Mussels are ecosystem engineers and farms can mitigate the consequences of eutrophication while providing ecosystem services. The development of mussel farming has been limited by competition for coastal space, intensification of the industry causing environmental impacts due to bioaccumulation around farms, negative public perception and lack of research. Offshore aquaculture has the potential to overcome such issues but knowledge on …

Does Individual Innovativeness Influence Tpack Development?: The Case Of Pre-Service Efl Teachers In Türkiye, Taibe Kulaksız

Australian Journal of Teacher Education

: This study aims to investigate how pre-service EFL teachers’ individual innovativeness levels affect their TPACK development during an educational technology course. Employing a quasi-experimental research design, the participants were 59 pre-service EFL teachers. The course followed the Diffusion of Innovation Theory steps. Analyzing the data, TPACK and individual innovativeness scales were implemented as pre- and post-tests. The results showed a significant increase in participants' TPACK, while their individual innovativeness did not exhibit a significant change during the course. Although there was a notable difference in pre-service teachers' initial TPACK levels based on their innovativeness, this difference was no longer …

The Criticality Of Teacher Educator Wellbeing: Reflecting Through Arts-Based Methods, Kristina Turner, Georgina M. Barton Dr, Susanne Garvis, Ellen Larsen

Australian Journal of Teacher Education

Teacher educators face many challenges related to workload and government-mandated reforms in Initial Teacher Education programs. Evidence suggests that COVID-19 has exacerbated these challenges as universities must become more cost-effective and improve research outcomes and impact, often resulting in heavier workloads. While these challenges may be faced in other disciplines, teacher educator wellbeing, stress and burnout is an under-researched field, and little is known about if and how teacher educators maintain their wellbeing during times of uncertainty. This collaborative autoethnographic study applied an arts-based research method to explore the wellbeing challenges faced by four Australian teacher educators through the lens …

How Are Preservice Teachers Discursively Positioned During Microteaching? The Views Of Student Teachers In Hong Kong, John Trent

Australian Journal of Teacher Education

This paper reports the results of a qualitative study that used in-depth interviews to understand the experiences and perceptions of six pre-service teachers as they engaged in microteaching at a tertiary institution in Hong Kong. Using a framework grounded in dialogism and positioning theory, the study describes the ways in which different discourses offer, as well as deny, positions to the pre-service teachers as they planned and implemented microlessons. The results suggest that competition between these discourses to position pre-service teachers can result in microteaching being associated with negative emotional experiences, such as disappointment, isolation, and frustration. This emotional dissonance …

Exploring Challenges Faced By Early Career Primary School Teachers: A Qualitative Study, Deborah Black, Gregory Hine, Shane Lavery

Australian Journal of Teacher Education

This study explored the challenges faced by 23 primary early career teachers (ECTs) in their second, third or fourth years of teaching. Qualitative data were collected through an online semi-structured interview. Three themes were evident: parents, workload and behaviour management. These results were also reflected in the review of the literature. All three themes have been linked to increased ECT stress and have been found to undermine ECTs’ self-confidence. The results suggest that some challenges are potentially aligned to the stage of ECTs’ career development and that ECTs face different challenges as their teaching experience levels increase. A range of …

"Sky-High Motivation": Intradisciplinary Integrative- Courses For Excelling Teachers' Training, Yael Kimhi

Australian Journal of Teacher Education

In many teacher education programs, curricula are comprised of fragmented courses within an academic discipline. This longitudinal study followed one cohort of teacher trainees in a fast-track B.Ed. program in Israel and explored an integrative approach to intradisciplinary courses. These courses were organized around significant themes and issues. A mixed-method methodology was implemented. The data included 81 teacher trainee responses, 16 mentor responses, and 11 college staff responses. Data were gathered during three years at four different time points: 1) online questionnaire for trainees and mentors (end of 1^st and 3^rd year); 2) trainee focus groups and steering …

Supporting Learners Through Effective Communication: Student Teachers’ Communication Strategies To Address Learner Behaviour, Jirina Karasova, Gabriela Kleckova

Australian Journal of Teacher Education

Teachers’ communication skills are integral to classroom management skills. If teachers implement effective communication skills and appropriate communication strategies, they are more likely to support learner autonomy, engagement, self-concept, well-being, or responsibility and succeed in behaviour management. This study examines student teachers’ awareness and use of communication strategies to address common disruptive learner behaviours. Although the participants showed limited ability to support learners through communication, they were more likely to identify effective communication responses than to produce them themselves. The study unveils that student teachers in the last year of a graduate program cannot respond to disruptive behaviour without communication …

The Impact Of Theatre Pedagogy On Student Teachers’ Development Of Beliefs About Good Teaching And Their Pedagogical Ethos: An Exploratory Case Study, Angela Hadjipanteli

Australian Journal of Teacher Education

The development of student teachers’ beliefs about good teaching needs to be integral to their education programmes. This study attempts to scrutinise the contribution of a theatre education course to the conceptualisation of a group of eight student primary teachers’ notion of good teaching and a teacher’s ethos. The findings reveal that, within the coursework, student teachers’ learning experiences are interwoven with the ethics of the beautiful, the ethics of the dialogue and the ethics of the will. This nexus of learning experiences enabled them to identify three internal goods of good teaching: the awakening of learners’ positive emotions; …

Transformative Learning Experiences Of The Vocationally Interested And Vocationally Disinterested Pre-Service Teachers In Teacher Training Colleges In Zimbabwe, Esnati Macharaga, Tabitha Grace Mukeredzi

Australian Journal of Teacher Education

This article reports on some of the findings from a doctoral research project that explored how the vocationally interested and vocationally disinterested pre-service teachers in selected teacher training colleges in Zimbabwe experienced transformative learning. Through multiple-site case study and qualitative approach within an interpretive paradigm, guided by Mezirow’s ten-phase Transformative Learning Theory, the study sought to understand the pre-service teacher transformative learning experiences. The study employed a multi-modal approach which involved focus group discussions, individual face to face interviews and continuum drawing and discussions to generate data from a purposive sample of 40 participants. Findings suggest that, both vocationally interested …

Teachers' Views On The Nature Of Science: An Epistemological Analysis, Rafael Amador Rodríguez, Natalia Ospina Quintero, Agustín Adúriz Bravo

Australian Journal of Teacher Education

This article presents results of research analysing the views on the nature of science (NOS) among primary and secondary teachers working in state schools in two different cities in Colombia. Previous studies have reported that science teachers maintain ‘eclectic’ epistemological perspectives on science; in this article, we test if such hypothesis holds when teachers’ ideas are ‘anchored’ in specific periods and topics of the philosophy of science. Thirty-five teachers attending a postgraduate teaching course with emphasis on the natural sciences at the Universidad del Norte (Barranquilla, Colombia) were assessed with the use of quantitative, descriptive and parametric research methods. The …

Participants’ Experiences In Heutagogy Teacher Professional Education In Indonesia, Silvia Handayani, Lewes Peddell, Tony Yeigh

Australian Journal of Teacher Education

This study investigated a heutagogy-informed teacher professional education model designed to assist Indonesian teachers in achieving the competencies established by the Indonesian government to address teacher quality issues. The critical concepts of the model include self-determined learning, metacognitive reflection, collaborative learning, and capability development. An embedded design methodology, grounded in pragmatism as the overarching research paradigm, was employed for this investigation. The findings of this study provide significant insights for enhancing teachers’ professional education in Indonesia, particularly in terms of the effectiveness of heutagogy-informed approaches compared to traditional approaches of teacher training, with additional benefits stemming from heutagogy-informed, technology-facilitated learning …

Teachers’ Experiences That Challenge Their Decision To Continue: What Teachers Really Need, Elizabeth Allotta

Australian Journal of Teacher Education

Increasing global teacher attrition rates and the difficulty of filling teacher positions in Australian schools have led to rising concerns about teacher supply and demand. While attrition factors and rates have been known for over thirty years, little has changed or improved. This raises the question, ‘how and why do some teachers continue while others leave?’ A postqualitative ethnographic study into the experiences that have challenged teachers’ decision to continue highlights the complexity of the issues underlying teacher attrition with known attrition factors, in particular workplace and time, being compounded by unspoken and silenced challenges that contribute to teachers leaving. …

Student Teachers’ Initial Professional Identity: A Case In An Efl Teacher Education Program, Uun Muhaji, Didi Sukyadi, Ahmad Bukhori Muslim

Australian Journal of Teacher Education

Student teachers enter teacher education programs with existing values, beliefs, and knowledge about teaching. However, little is known about the significant resources that shape this initial professional identity. Additionally, there is a lack of understanding regarding how first-year student teachers depict their initial professional identity in the context of Indonesia. This case study examines the initial professional identity of 23 first-year Indonesian student teachers in an English as a Foreign Language Teacher Education Program (EFLTEP) in Indonesia. Utilizing Esteban-Guitart's Funds of Identity theory, data were collected through participants' narratives via significant circles, self-portrait drawings and interviews. Data were …

Arguing For The Subjectification Of Graduate Teachers, Karen Maras, Geraldine Townend, Tony Loughland, Hoa Nguyen, Dennis Alonzo, Marie Mcgregor, Andy Gao, Tanya Kwee

Australian Journal of Teacher Education

The quality of graduate teachers is a significant concern for teacher educators, policymakers and the public. Initiatives regarding the quality assurance of initial teacher education (ITE) programs require critical examination to ensure that ITE programs develop proficient graduate teachers to meet the demands of modern classrooms. In this paper, we draw on Biesta’s (2015, 2019, 2020) theoretical framing of purpose in education (i.e., qualification, socialisation and subjectification) to analyse the policy texts related to graduate teaching performance assessment from institutions involved in the creation and implementation of the Teaching Performance Assessment (TPA) in ITE in Australia. Researchers used document analysis …

Scaffolding Methods And The Long Shadow Of Ramist Formalism: A Call For Correction In Teacher Education, Brian R. Moon

Australian Journal of Teacher Education

Modern Anglophone pedagogy is characterised by some distinctive approaches to teaching and learning that set it apart from earlier instructional traditions. Among these are certain forms of scaffolding that emphasise students’ construction of knowledge. Such methods are consistent with a trend toward visible activity and display in pedagogical practice, in place of dialogue and inner contemplation. In ITE courses, scaffolding strategies are promoted to beginning teachers as novel and effective products of modern cognitive psychology and constructivist theories of learning. Here I offer a historical correction to that view, demonstrating that today’s popular scaffolding strategies have a much longer history, …

Mapping Assessment Tasks And Lecturer Considerations: A Case Study Of A Nz Primary Teacher Education Programme, Wendy Carss, Bronwen Cowie, Sheralyn Cook

Australian Journal of Teacher Education

Initial teacher education programme and paper assessments need to encompass university degree requirements and attest to student mastery of teacher professional competencies. This article reports one aspect of an investigation of the nature and principles employed in the design of assessments for a three-year Bachelor of Teaching (Primary) programme. The assessment tasks included in the 2022 academic papers were mapped and paper leaders interviewed; practicum and placement papers were not included because these were being redeveloped at the time. Findings are consistent with assessment design principles associated with authenticity and equity of access to the demonstration of understanding through tasks …

Fenceposts Without A Fence, Katherine E. Di Lucido, Nicholas Tabor

Vanderbilt Law Review En Banc

No abstract provided.

Front Matter, Colorado Technology Law Journal

Colorado Technology Law Journal

No abstract provided.

Life After Death: A Field Experiment With Small Businesses On Information Frictions, Stigma, And Bankruptcy, Shai Bernstein, Emanuele Colonnelli, Mitchell Hoffman

Faculty Publications

In an RCT with US small businesses, we document that a large share of firms are not well-informed about bankruptcy. Many assume that bankruptcy necessarily entails the death of a business and do not know about Chapter 11, where debts are renegotiated so that the business can continue operating. Firms also exhibit bankruptcy-related stigma, believing that bankruptcy is embarrassing, a sign of failure, and a negative signal to employees and customers. Short educational videos that address information or stigma increase knowledge and decrease stigma, both immediately and durably over 4 months. Videos increase reported interest in using Chapter 11 bankruptcy …

The Influence Of Intrinsic And Extrinsic Factors In A Trap-Neuter-Release (Tnr) Program And Its Effects On Urban And Rural Demographics As A Long-Term Solution For Community Cat Management, Hannah E. Litke

Graduate Research Papers

Trap-neuter-release is a humane alternative solution to aid in decreasing community cat populations. This research paper evaluates the intrinsic and extrinsic factors contributing to successful community cat populations, including reproductive success, transmission of feline and zoonotic diseases, population size, cat immigration between colonies, food availability, and wildlife extinction. Additionally, this research paper evaluates and analyzes TNR's impacts on urban and rural demographics. Furthermore, the paper will evaluate TNR as a long-term solution and its effectiveness in decreasing community cat populations. Lastly, this paper provides suggestions for future research regarding community cat populations.