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2023

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A Fate Determination Fork-In-The-Road For Germinal Center Tfh And T Memory Cells, Jeff Hansen Aug 2023

A Fate Determination Fork-In-The-Road For Germinal Center Tfh And T Memory Cells, Jeff Hansen

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No abstract provided.

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Enhancing The Performance Of Microbial Fuel Cells Via Metabolic Engineering Of Escherichia Coli For Phenazine Production, Olja Simoska, Dale A. Cummings, Erin M. Gaffney, Claire Langue, Tommy G. Primo, Courtney J. Weber, Corbin E. Witt, Shelley D. Minteer Aug 2023

Enhancing The Performance Of Microbial Fuel Cells Via Metabolic Engineering Of Escherichia Coli For Phenazine Production, Olja Simoska, Dale A. Cummings, Erin M. Gaffney, Claire Langue, Tommy G. Primo, Courtney J. Weber, Corbin E. Witt, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

One of the central roles in the design, development, and application advances in mediator-Based microbial electrochemical systems, such as microbial fuel cells (MFCs), is the establishment of efficient and successful communication between conductive electrode surfaces and microorganisms via modes of extracellular electron transfer (EET). Most microbial-Based systems require the use of artificial electroactive mediators in order to facilitate and/or enhance electron transfer. Our previous work established an exogenous phenazine-Based library as a mediator system to enable EET from the model microorganism Escherichia coli as a promising biotechnological host. However, the addition of exogenous mediators to a microbial electrochemical system has …

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The Teacher Becomes The Student: Uab Chemistry Ph.D. Graduate Set To Research Microplastics In Hawaii As A Postdoctoral Fellow, Micah Hardge Aug 2023

The Teacher Becomes The Student: Uab Chemistry Ph.D. Graduate Set To Research Microplastics In Hawaii As A Postdoctoral Fellow, Micah Hardge

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No abstract provided.

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Multi-Color Fluorescent Microscopy And Deep Learning For Studying Eukaryotic Organelles: Unveiling Cellular Growth In A System Biology Perspective, Shixing Wang Aug 2023

Multi-Color Fluorescent Microscopy And Deep Learning For Studying Eukaryotic Organelles: Unveiling Cellular Growth In A System Biology Perspective, Shixing Wang

Arts & Sciences Graduate Student Theses and Dissertations

Eukaryotic cells are building blocks to complex living systems, characterized by membrane-bound organelles. Studying how eukaryotic organelles react to cellular growth and size increase is crucial, but it demands biochemical and biophysical manipulations, as well as quantitative observation tools in microscopy. We developed a multi-color yeast strain with tagged fluorescent proteins, enabling systematic measurements of 6 organelles inside each cell using spectral confocal microscopy. These measurements provided insights into how organelle biogenesis is coordinated with cellular size and growth rate regulation via different signaling pathways. To explore cellular growth under dynamic conditions, I utilized deep learning for organelle recognition using …

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Investigating Novel Neoantigen Sources For Personalized Cancer Vaccines, Megan Richters Aug 2023

Investigating Novel Neoantigen Sources For Personalized Cancer Vaccines, Megan Richters

Arts & Sciences Graduate Student Theses and Dissertations

The adaptive immune system has inherent antitumor properties that are capable of inducing tumor-specific cell death. CD8+ and CD4+ T cells, two immune cell types critical to this process, recognize antigens bound by class I and II major histocompatibility complexes on the cell surface, respectively. After antigen recognition, T cells can signal growth arrest and cell death to tumor cells displaying the antigen. Neoantigens, or tumor-specific peptides, are targeted by cancer immunotherapies to induce T cell-mediated degradation. Treatments such as personalized vaccines and immune checkpoint blockade thus provide a unique avenue to selectively recognize and destroy tumor cells while keeping …

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Function Of Deubiquitinase Mysm1 In Attenuation Of Dna Damage Responses, Brendan Mathias Aug 2023

Function Of Deubiquitinase Mysm1 In Attenuation Of Dna Damage Responses, Brendan Mathias

Arts & Sciences Graduate Student Theses and Dissertations

MYSM1 deficiency has been identified in patients with B cell lymphopenia, hypogammaglobulinemia, primary immune deficiency and bone marrow failure. MYSM1 is a known deubiquitinase that acts on histone H2A to promote gene expression. MYSM1 also functions in cellular responses to DNA injury and patients with loss of MYSM1 have increased sensitivity to DNA damaging agents. The specific role and function of MYSM1 in DNA damage responses has yet to be determined. Here, I have shown that MYSM1 does not mediate generation or repair of DSBs, but rather acts to attenuate and terminate DNA damage signaling after repair. Loss of MYSM1 …

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Investigation Of Metabolic And Molecular Pathways That Promote Gastric Parietal Cell Regeneration, Mahliyah Lenore Adkins-Threats Aug 2023

Investigation Of Metabolic And Molecular Pathways That Promote Gastric Parietal Cell Regeneration, Mahliyah Lenore Adkins-Threats

Arts & Sciences Graduate Student Theses and Dissertations

The stomach contains gastric epithelial cells, including acid-pumping parietal cells (PCs), that are constantly renewed throughout life from a multipotent stem cell to maintain a balance between producing and protecting from the acid and enzymes needed to kill pathogens and initiate digestion. Despite this dynamic renewal, disorders of the gastric epithelium occur and are one of the most common etiologies of human diseases ranging from simple heartburn to reflux, peptic ulcers and gastric cancer. PCs are characterized by elaborate plasma membrane foldings and vesicles that house their proton pumps and an abundance of mitochondria needed to power secretion of that …

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Self-Supervised Pretraining And Transfer Learning On Fmri Data With Transformers, Sean Paulsen Aug 2023

Self-Supervised Pretraining And Transfer Learning On Fmri Data With Transformers, Sean Paulsen

Dartmouth College Ph.D Dissertations

Transfer learning is a machine learning technique founded on the idea that knowledge acquired by a model during “pretraining” on a source task can be transferred to the learning of a target task. Successful transfer learning can result in improved performance, faster convergence, and reduced demand for data. This technique is particularly desirable for the task of brain decoding in the domain of functional magnetic resonance imaging (fMRI), wherein even the most modern machine learning methods can struggle to decode labelled features of brain images. This challenge is due to the highly complex underlying signal, physical and neurological differences between …

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Grounding Line And Calving Front Retreat In Glomar Challenger Basin And Pennell Trough Of Ross Sea, Antarctica Reconstructed From Diatom Abundances And Assemblages, Jaren Bradford Aug 2023

Grounding Line And Calving Front Retreat In Glomar Challenger Basin And Pennell Trough Of Ross Sea, Antarctica Reconstructed From Diatom Abundances And Assemblages, Jaren Bradford

LSU Master's Theses

Previous studies showed that West Antarctic Ice Sheet (WAIS) retreat from the Whales Deep Basin continental shelf edge in eastern Ross Sea was underway by 14.7 ± 0.4 cal kyr BP. Following an ice-shelf breakup at 12.3 ± 0.6 cal kyr BP, a calving cliff margin remained within 60 km of the shelf edge until 11.5 ± 0.3 cal kyr BP. McGlannan et al. (2017) inferred that an ice shelf reformed immediately during a subsequent rapid retreat. That interpretation of grounding-line retreat with an intact ice shelf is being reevaluated by Sivils (in prep.). Here, we conducted a similar synthesis …

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Exploring The Role Of Salt-Tolerant Halomonas Inoculant In Altering Plant Gene Expression To Improve Salt Tolerance In Alfalfa., Ashley Kay Miller Aug 2023

Exploring The Role Of Salt-Tolerant Halomonas Inoculant In Altering Plant Gene Expression To Improve Salt Tolerance In Alfalfa., Ashley Kay Miller

Theses and Dissertations

Soil salinity is an increasing problem facing agriculture in many parts of the world. Climate change and irrigation practices have led to decreased yields of large areas of farmland due to increased salt levels in the soil. Irrigation introduces salts to the soil that with time accumulate and threaten crop yield. In arid climates like Utah, the practice of irrigation is especially threatening to salt-sensitive crops including alfalfa (Medicago sativa). Plants that have tolerance to salt are needed to feed livestock and the world's population. One approach to address this problem is to introduce genes encoding salt tolerance into the …

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Mahu And Native Hawaiian Culture: Experiences Of Non-Heteronormativity, Rachel Beth Chapman Aug 2023

Mahu And Native Hawaiian Culture: Experiences Of Non-Heteronormativity, Rachel Beth Chapman

Theses and Dissertations

There are extensive amounts of psychological research that highlight the needs and experiences of racial ethnic minority populations in general and more specifically minority sexual identities and genders, also referred to as non-heteronormative populations (Alexeyeff & Besnier, 2014). However, there continues to be a lack of representation in the research of Polynesians and an even greater lack of representation of non-heteronormative Polynesians and their experiences (Allen et al., 2011). Māhū, a population of native Hawaiians who identify as non-heteronormative or third gender, are almost completely absent from scholarly work. This study examines the experience of self-identified māhū and how mental …

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An Assessment Of Cattle Traffic On, And Seed Dispersion Patterns Of, Sclerocactus Wrightiae, David D. Lariviere Aug 2023

An Assessment Of Cattle Traffic On, And Seed Dispersion Patterns Of, Sclerocactus Wrightiae, David D. Lariviere

Theses and Dissertations

Cattle grazing has been a historic use of rangelands in Utah since Pioneer settlement in the mid 1800's. Wright fishhook cactus is a small globose cactus endemic to an area of 280,000 ha in south-central Utah and was listed as endangered in October of 1979, by the U.S. Fish and Wildlife Service (USFWS). By 2010, concerns were expressed that soil compaction in proximity to the cactus posed a threat to this species, though there was no empirical data to support such concern. In order to assess the impact of cattle traffic on Wright fishhook cactus, we used an imprint device …

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Forgotten Voices: Japanese War Orphans In China, Feimo Zhu Aug 2023

Forgotten Voices: Japanese War Orphans In China, Feimo Zhu

Theses - ALL

Research on World War II (WWII) history has predominantly focused on the European theater, with limited attention given to the war’s events in Asia. The scarcity of in-depth studies conducted by Asian historians necessitates an investigation into the complex events that unfolded in this region during this significant period in world history. This study aims to shed light on the often-neglected history of Japanese war orphans in China during WWII and their lives in the post-war era. To provide readers with a comprehensive understanding of the war’s impact on the lives of ordinary individuals, this study follows the historical timeline …

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Forgotten Voices: Japanese War Orphans In China, Feimo Zhu Aug 2023

Forgotten Voices: Japanese War Orphans In China, Feimo Zhu

Theses - ALL

Research on World War II (WWII) history has predominantly focused on the European theater, with limited attention given to the war’s events in Asia. The scarcity of in-depth studies conducted by Asian historians necessitates an investigation into the complex events that unfolded in this region during this significant period in world history. This study aims to shed light on the often-neglected history of Japanese war orphans in China during WWII and their lives in the post-war era. To provide readers with a comprehensive understanding of the war’s impact on the lives of ordinary individuals, this study follows the historical timeline …

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Using De Novo Transcriptomes To Decipher The Relationships In Cutthroat Trout Subspecies (Oncorhynchus Clarkii), Andrea Leena Kokkonen Aug 2023

Using De Novo Transcriptomes To Decipher The Relationships In Cutthroat Trout Subspecies (Oncorhynchus Clarkii), Andrea Leena Kokkonen

Theses and Dissertations

Cutthroat trout (Oncorhynchus clarkii) is a salmonid native to Western North America. For almost 200 years, the taxonomy of these species has fluctuated as ichthyologists and fisheries managers alike have tried to understand the diversity seen within these fishes. In the 1950s, Robert Behnke reexamined the cutthroat trout and identified 14 subspecies based on morphological observations, Pleistocene events, and modern geographic ranges. These designations were instrumental in preserving the remaining diversity of cutthroat trout. Over time, molecular techniques (i.e. karyotypes, allozymes, and mtDNA) have largely replicated Behnke's phylogenies. However, these studies have revealed that some of these relationships are consistently …

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Evapotranspiration In Urban And Agricultural Systems With Interacting Irrigation And Nitrogen Fertilizer Treatments, Samantha R. Shumate Aug 2023

Evapotranspiration In Urban And Agricultural Systems With Interacting Irrigation And Nitrogen Fertilizer Treatments, Samantha R. Shumate

Theses and Dissertations

Nitrogen (N) fertilizer and irrigation are important inputs for all managed plant species, especially in arid and semi-arid climates. The interaction between N management and irrigation can lead to more sustainable practices. This is true for both agricultural and urban environments. Precision nutrient management has been widely adopted by producers in recent decades, and water conservation has become an important goal for turfgrass managers. In urban systems, our goal was to evaluate Kentucky bluegrass (Poa pratensis L.) to determine response to three N fertilizer rates and three irrigation rates in all possible combinations. The main and interacting treatment effects were …

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Improving Xrd Analysis With Machine Learning, Rachel E. Drapeau Aug 2023

Improving Xrd Analysis With Machine Learning, Rachel E. Drapeau

Theses and Dissertations

X-ray diffraction analysis (XRD) is an inexpensive method to quantify the relative proportions of mineral phases in a rock or soil sample. However, the analytical software available for XRD requires extensive user input to choose phases to include in the analysis. Consequently, analysis accuracy depends greatly on the experience of the analyst, especially as the number of phases in a sample increases (Raven & Self, 2017; Omotoso, 2006). The purpose of this project is to test whether incorporating machine learning methods into XRD software can improve the accuracy of analyses by assisting in the phase-picking process. In order to provide …

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Using Μct Scans To Create 3d Skull Puzzles As Open-Access Pedagogical Tools For Anatomy And Comparative Osteology Classes., Alexis Slack Aug 2023

Using Μct Scans To Create 3d Skull Puzzles As Open-Access Pedagogical Tools For Anatomy And Comparative Osteology Classes., Alexis Slack

Honors Thesis

As access to affordable 3D printing technologies increases, the use of Computed Tomography (CT) technologies is well positioned to contribute to the advancement of pedagogical experiences through the creation of physical models for teaching. Such complementary efforts may enhance broader impacts by simultaneously boosting the education system with a unique hands-on experience for students and providing an alternative to expensive osteological and other artificial models. Two 3D printed skull puzzles were created to aid in teaching human and vertebrate anatomy, and comparative osteology courses. After segmenting all the bones from each respective skull, the individual skeletal elements were 3D printed, …

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Course Experiences That Promote And Inhibit Human-Centered Design, Elizabeth A. Sanders, Molly Goldstein, Justin L. Hess Aug 2023

Course Experiences That Promote And Inhibit Human-Centered Design, Elizabeth A. Sanders, Molly Goldstein, Justin L. Hess

School of Engineering Education Faculty Publications

Engineers contribute to large-scale socio-technical challenges, and human-centered design offers a design thinking approach that helps engineers develop a thorough understanding of the socio-technical effects of their design work. Thus, effective strategies for assessing and teaching human-centered design are needed. This study aimed to identify course characteristics that influence how students experience human-centered design in an introductory systems engineering design course. First, we categorized open-ended written reflections to understand the degree to which students experienced human-centered design. Second, we performed a thematic analysis to characterize salient course experiences for two groups of students: (1) students who experienced human-centered design in …

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Loss Of Syncrip Unleashes Apobec-Driven Mutagenesis, Tumor Heterogeneity, And Ar-Targeted Therapy Resistance In Prostate Cancer, Xiaoling Li, Yunguan Wang, Su Deng, Guanghui Zhu, Choushi Wang, Nickolas A Johnson, Zeda Zhang, Carla Rodriguez Tirado, Yaru Xu, Lauren A Metang, Julisa Gonzalez, Atreyi Mukherji, Jianfeng Ye, Yuqiu Yang, Wei Peng, Yitao Tang, Mia Hofstad, Zhiqun Xie, Heewon Yoon, Liping Chen, Xihui Liu, Sujun Chen, Hong Zhu, Douglas Strand, Han Liang, Ganesh Raj, Housheng Hansen He, Joshua T Mendell, Bo Li, Tao Wang, Ping Mu Aug 2023

Loss Of Syncrip Unleashes Apobec-Driven Mutagenesis, Tumor Heterogeneity, And Ar-Targeted Therapy Resistance In Prostate Cancer, Xiaoling Li, Yunguan Wang, Su Deng, Guanghui Zhu, Choushi Wang, Nickolas A Johnson, Zeda Zhang, Carla Rodriguez Tirado, Yaru Xu, Lauren A Metang, Julisa Gonzalez, Atreyi Mukherji, Jianfeng Ye, Yuqiu Yang, Wei Peng, Yitao Tang, Mia Hofstad, Zhiqun Xie, Heewon Yoon, Liping Chen, Xihui Liu, Sujun Chen, Hong Zhu, Douglas Strand, Han Liang, Ganesh Raj, Housheng Hansen He, Joshua T Mendell, Bo Li, Tao Wang, Ping Mu

Faculty, Staff and Student Publications

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the mutational signatures of more than 70% of human cancers. However, the mechanism underlying how cancer cells hijack the APOBEC mediated mutagenesis machinery to promote tumor heterogeneity, and thereby foster therapy resistance remains unclear. We identify SYNCRIP as an endogenous molecular brake which suppresses APOBEC-driven mutagenesis in prostate cancer (PCa). Overactivated APOBEC3B, in SYNCRIP-deficient PCa cells, is a key mutator, representing the molecular source of driver mutations in some frequently mutated genes in PCa, including FOXA1, …

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Bacteroides Uniformis-Induced Perturbations In Colonic Microbiota And Bile Acid Levels Inhibit Th17 Differentiation And Ameliorate Colitis Developments, Yiting Yan, Yu Lei, Ying Qu, Zhen Fan, Ting Zhang, Yangbin Xu, Qian Du, Daniel Brugger, Yulin Chen, Ke Zhang, Enping Zhang Aug 2023

Bacteroides Uniformis-Induced Perturbations In Colonic Microbiota And Bile Acid Levels Inhibit Th17 Differentiation And Ameliorate Colitis Developments, Yiting Yan, Yu Lei, Ying Qu, Zhen Fan, Ting Zhang, Yangbin Xu, Qian Du, Daniel Brugger, Yulin Chen, Ke Zhang, Enping Zhang

Faculty, Staff and Student Publications

Inflammatory bowel disease (IBD) is associated with gut dysbiosis and can lead to colitis-associated malignancies. Bacteroides uniformis (Bu) regulates animal intestinal homeostasis; however, the mechanism by which it alleviates colitis in mice remains unknown. We investigated the effects of B. uniformis JCM5828 and its metabolites on female C57BL/6J mice with dextran sulfate sodium salt (DSS) induced colitis. Treatment with Bu considerably alleviated colitis progression and restored the mechanical and immune barrier protein expression. Additionally, Bu increased the abundance of the symbiotic bacteria Bifidobacterium and Lactobacillus vaginalis while decreasing that of pathogenic Escherichia-Shigella, and modulated intestinal bile acid metabolism. Bu largely …

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Mass Spectrometry-Based Discovery Of Tumor Antigens For Cancer Immunotherapy, Wei Meng Aug 2023

Mass Spectrometry-Based Discovery Of Tumor Antigens For Cancer Immunotherapy, Wei Meng

Arts & Sciences Graduate Student Theses and Dissertations

The immune system plays an essential role in cancer evolution and cancer treatment. One of the major mechanisms of immune-mediated tumor rejection is the recognition of tumor antigens by T cells. Upon recognition of tumor antigens, naïve T cells become activated and subsequently infiltrate inside the tumor. Since the early discovery of tumor-specific T cells, many efforts have elucidated the molecular nature of their cognate antigens. It is now established that MHC-I and MHC-II restricted peptides are critical to generate CD8+ and CD4+ antigen-specific T cells that can recognize tumor-derived antigens. Two main categories of these antigens are those originating …

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Understanding Gender Identification Within Individuals With Autism Using The Bem Sex-Role Inventory, Zackery Alan Cusworth Aug 2023

Understanding Gender Identification Within Individuals With Autism Using The Bem Sex-Role Inventory, Zackery Alan Cusworth

Theses and Dissertations

Gender is a socially derived construct that is taught and understood at young ages. However, not every individual has the same social skills to understand these seen and unseen social cues about gender. The Bem Sex-Role Inventory was given to adult individuals with autism in the United States to better understand their masculine, feminine, and androgenous perceptions. These data were then compared to the original Bem Sex-Role Inventory general population study to see if there were any differences. The data show that males with autism had lower masculine scores and higher feminine scores than males in the general population. Females …

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Lessons From The Maui Wildfires For Human Solidarity And The Fight Against Huntington’S And Other Diseases, Kenneth P. Serbin Phd Aug 2023

Lessons From The Maui Wildfires For Human Solidarity And The Fight Against Huntington’S And Other Diseases, Kenneth P. Serbin Phd

At Risk for Huntington's Disease

No abstract provided.

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Environmental Toxins And Their Impact On Neurological Health, Maria Allesandra Elsasser Aug 2023

Environmental Toxins And Their Impact On Neurological Health, Maria Allesandra Elsasser

Master's Projects and Capstones

This paper evaluates the impact of environmental toxins on neurological health from a public health perspective. Employing a comprehensive review of literature across various databases, the study sheds light on the mechanisms through which environmental neurotoxicity influences health, highlighting key correlations between toxin exposure and the onset of neurodegenerative disorders. The research identifies significant gaps in current approaches to managing these risks, particularly concerning policy regulations and public awareness. Based on these findings, strategic recommendations are proposed to address and mitigate the identified challenges, with implications emphasizing the broader benefits for public health.

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Decentralized Sensor Fault-Tolerant Control Of Dc Microgrids Using The Attracting Ellipsoid Method, Ehab Bayoumi Aug 2023

Decentralized Sensor Fault-Tolerant Control Of Dc Microgrids Using The Attracting Ellipsoid Method, Ehab Bayoumi

Mechanical Engineering

System stability deterioration in microgrids commonly occurs due to unpredictable faults and equipment malfunctions. Recently, robust control techniques have been used in microgrid systems to address these difficulties. In this paper, for DC-islanded microgrids that have sensors faults, a new passive fault-tolerant control strategy is developed. The suggested approach can be used to maintain system stability in the presence of flaws, such as faulty actuators and sensors, as well as component failures. The suggested control is effective when the fault is never recognized (or when the fault is not being precisely known, and some ambiguity in the fault may be …

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Phenomics As An Approach To Comparative Developmental Physiology, Jamie C.S. Mccoy, John I. Spicer, Ziad Ibbini, Oliver Tills Aug 2023

Phenomics As An Approach To Comparative Developmental Physiology, Jamie C.S. Mccoy, John I. Spicer, Ziad Ibbini, Oliver Tills

School of Biological and Marine Sciences

The dynamic nature of developing organisms and how they function presents both opportunity and challenge to researchers, with significant advances in understanding possible by adopting innovative approaches to their empirical study. The information content of the phenotype during organismal development is arguably greater than at any other life stage, incorporating change at a broad range of temporal, spatial and functional scales and is of broad relevance to a plethora of research questions. Yet, effectively measuring organismal development, and the ontogeny of physiological regulations and functions, and their responses to the environment, remains a significant challenge. “Phenomics”, a global approach to …

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Toll-Like Receptor 4 And Macrophage Scavenger Receptor 1 Crosstalk Regulates Phagocytosis Of A Fungal Pathogen, Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May Aug 2023

Toll-Like Receptor 4 And Macrophage Scavenger Receptor 1 Crosstalk Regulates Phagocytosis Of A Fungal Pathogen, Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May

School of Biomedical Sciences

The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phagocytosed by macrophages. Here we investigate the role of TLR4 in the non-opsonic phagocytosis of C. neoformans. We find that loss of TLR4 function unexpectedly increases phagocytosis of non-opsonised cryptococci by murine and human macrophages. The increased phagocytosis observed in Tlr4−/− cells was dampened by pre-treatment of macrophages with oxidised-LDL, a known ligand of scavenger receptors. The scavenger receptor, macrophage scavenger receptor 1 (MSR1) (also known as SR-A1 or …

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Proteogenomic Data And Resources For Pan-Cancer Analysis, Yize Li, Yongchao Dou, Felipe Da Veiga Leprevost, Yifat Geffen, Anna P Calinawan, François Aguet, Yo Akiyama, Shankara Anand, Chet Birger, Song Cao, Rekha Chaudhary, Padmini Chilappagari, Marcin Cieslik, Antonio Colaprico, Daniel Cui Zhou, Corbin Day, Marcin J Domagalski, Myvizhi Esai Selvan, David Fenyö, Steven M Foltz, Alicia Francis, Tania Gonzalez-Robles, Zeynep H Gümüş, David Heiman, Michael Holck, Runyu Hong, Yingwei Hu, Eric J Jaehnig, Jiayi Ji, Wen Jiang, Lizabeth Katsnelson, Karen A Ketchum, Robert J Klein, Jonathan T Lei, Wen-Wei Liang, Yuxing Liao, Caleb M Lindgren, Weiping Ma, Lei Ma, Michael J Maccoss, Fernanda Martins Rodrigues, Wilson Mckerrow, Ngoc Nguyen, Robert Oldroyd, Alexander Pilozzi, Pietro Pugliese, Boris Reva, Paul Rudnick, Kelly V Ruggles, Dmitry Rykunov, Sara R Savage, Michael Schnaubelt, Tobias Schraink, Zhiao Shi, Deepak Singhal, Xiaoyu Song, Erik Storrs, Nadezhda V Terekhanova, Ratna R Thangudu, Mathangi Thiagarajan, Liang-Bo Wang, Joshua M Wang, Ying Wang, Bo Wen, Yige Wu, Matthew A Wyczalkowski, Yi Xin, Lijun Yao, Xinpei Yi, Hui Zhang, Qing Zhang, Maya Zuhl, Gad Getz, Li Ding, Alexey I Nesvizhskii, Pei Wang, Ana I Robles, Bing Zhang, Samuel H Payne Aug 2023

Proteogenomic Data And Resources For Pan-Cancer Analysis, Yize Li, Yongchao Dou, Felipe Da Veiga Leprevost, Yifat Geffen, Anna P Calinawan, François Aguet, Yo Akiyama, Shankara Anand, Chet Birger, Song Cao, Rekha Chaudhary, Padmini Chilappagari, Marcin Cieslik, Antonio Colaprico, Daniel Cui Zhou, Corbin Day, Marcin J Domagalski, Myvizhi Esai Selvan, David Fenyö, Steven M Foltz, Alicia Francis, Tania Gonzalez-Robles, Zeynep H Gümüş, David Heiman, Michael Holck, Runyu Hong, Yingwei Hu, Eric J Jaehnig, Jiayi Ji, Wen Jiang, Lizabeth Katsnelson, Karen A Ketchum, Robert J Klein, Jonathan T Lei, Wen-Wei Liang, Yuxing Liao, Caleb M Lindgren, Weiping Ma, Lei Ma, Michael J Maccoss, Fernanda Martins Rodrigues, Wilson Mckerrow, Ngoc Nguyen, Robert Oldroyd, Alexander Pilozzi, Pietro Pugliese, Boris Reva, Paul Rudnick, Kelly V Ruggles, Dmitry Rykunov, Sara R Savage, Michael Schnaubelt, Tobias Schraink, Zhiao Shi, Deepak Singhal, Xiaoyu Song, Erik Storrs, Nadezhda V Terekhanova, Ratna R Thangudu, Mathangi Thiagarajan, Liang-Bo Wang, Joshua M Wang, Ying Wang, Bo Wen, Yige Wu, Matthew A Wyczalkowski, Yi Xin, Lijun Yao, Xinpei Yi, Hui Zhang, Qing Zhang, Maya Zuhl, Gad Getz, Li Ding, Alexey I Nesvizhskii, Pei Wang, Ana I Robles, Bing Zhang, Samuel H Payne

Faculty, Staff and Students Publications

The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets connecting genomic aberrations to cancer phenotypes. To facilitate pan-cancer investigations, we have generated harmonized genomic, transcriptomic, proteomic, and clinical data for >1000 tumors in 10 cohorts to create a cohesive and powerful dataset for scientific discovery. We outline efforts by the CPTAC pan-cancer working group in data harmonization, data dissemination, and computational resources for aiding biological discoveries. We also discuss challenges for multi-omics data integration and analysis, specifically the unique challenges of working with both nucleotide sequencing and mass spectrometry …

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Exploring Chemovar-Specific Cannabis Extracts Quantification And Evaluation Of Cytotoxic Compounds For Targeting Glioblastoma Multiforme, Ashraf Duzan, Mufeed Basti, Travis Cesarone, Waldemar Debinski, Daniel Todd Aug 2023

Exploring Chemovar-Specific Cannabis Extracts Quantification And Evaluation Of Cytotoxic Compounds For Targeting Glioblastoma Multiforme, Ashraf Duzan, Mufeed Basti, Travis Cesarone, Waldemar Debinski, Daniel Todd

HPD Articles

Glioblastoma Multiforme (GBM) represents one of the most aggressive and metastatic brain tumors, with a dismal success rate of less than three percent after five years, particularly in tumors with active immune checkpoints. This necessitates the development of targeted endogenous agents for precise GBM treatment. Previous experiments utilizing Chemovar Specific Cannabis Extractions (CSCEs), fractionated with polar solvents and quantified using Liquid and Gas Column Chromatography combined with Mass Spectrometry (LC/GCMS), have shown reduced viability and motility in human GBM cell lines. However, the complexity of the botanical substance has hindered the personalization of standard cannabis medicines for GBM due to …

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