Digital Commons Network^™

Chronic Lower Back Pain Among Women In India: Evidence-Based Approach To Risk Factors And Interventions, Aelita Matosova

Master's Projects and Capstones

Chronic lower back pain (CLBP) is a prevalent issue worldwide, affecting about 1.71 billion people, with a significant proportion being women. CLBP is a major health concern in India, particularly among women, which were 80% reported experiencing this condition. Several factors, such as personal beliefs, sociocultural norms, restricted healthcare access, repetitive movements, and psychological aspects, contribute to this high prevalence leading to severe health and economic implications, including reduced work productivity and income. Although there have been several reports on prevalence and risk factors of CLBP, to our knowledge, there has not been enough work focusing on evidence-based interventions to …

Response Of Four Local Cassava Accessions To Bio-Mulch Application Time, Bayu Suwitono, Muhamad Achmad Chozin, Dwi Guntoro, Suwarto

Jurnal Kultivasi

Cassava (Manihot esculenta Crantz) is widely planted on marginal land with low soil fertility. During the initial growth phase, cassava often loses competition against weeds. Legume cover crops are widely used to increase soil fertility, prevent erosion, and suppress weeds. This study aimed to determine the effect of Arachis pintoi bio-mulch application time on the growth and yield of cassava. This study was conducted using a factorial randomized block design. The first factor was four cassava accessions: Ketan Malang, Genjah Bayam, IR Jonggol, and Mangu. The second factor was six levels of bio-mulch planting time: manual weeding (without bio-mulch applications), …

A Review Of Sapodilla Beneficial Use, Production Status, And Propagation Technique, Rahmat Budiarto, Syahvan Rifqi Dwinanda, Hansel Arie Pakpahan, Mega Komala, Yusti

Jurnal Kultivasi

Manilkara zapota, commonly known as sapodilla, is one of tropical fruits, originating from Central and South America that is still less popular in Indonesia, as compared to banana, citrus, mango, etc. To gain its popularity, it is crucial to review beneficial uses, existing production status and propagation techniques of sapodilla. In general, sapodilla is used for either table fresh fruit. Additionally, it contains various bioactivities in its fruit, stem, and leaves, such as antioxidant, antimicrobe, and antitumor activity; thus, become very potential for pharmaceutical purposes. The existing production data of sapodilla determine the West Java Province as the biggest production …

Effectiveness Of Modified Nitrogen Fertilizer On Soil Chemical Properties And Rice Plant Growth In The Textile Industrial Area, Rija Sudirja, Santi Rosniawaty, Sri Muji Rahayu, Budy Frasetya Taufik Qurrohman

Jurnal Kultivasi

The imbalance of nutrients and heavy metal contamination is a challenge in increasing plant growth surround the textile industry area. This study aimed to determine the effectiveness of the dosage of Biologically Agent N Organo Mineral Fertilizer (Biomix-N) as a fertilizer and an ameliorant in paddy soil contaminated with textile liquid waste. This study used a randomized block design of eight treatments with four replications. Parameters observed were soil chemical properties after application of Biomix-N (Na-ex, total N, EC, Cd, and pH), rice plant growth (plant height and tiller number), Cd concentration in the plant, and relative agronomic effectiveness (RAE). …

Gender Impact On Trauma-Exposed Populations, Melissa Flannigan

Graduate Teacher Education

Gender differences in trauma exposure have been well-established in published research. This paper explored the relationship between gender and its impact on exposure to traumatic events and the outcomes within trauma-exposed populations. Trauma can have profound and lasting effects on physical, mental, social, and behavioral well-being. The literature review identified gender differences in exposure to trauma types, PTSD prevalence and symptomatology, other mental health disorders, behavioral outcomes, and differences in physical health. Additionally, it explored the role of support systems, coping mechanisms, and risk factors for particular trauma-related outcomes. Furthermore, this paper examined the implications of the findings for professional …

Measures And Models Of Visual Acuity In Epipelagic And Mesopelagic Teleosts And Elasmobranchs, Eleanor M. Caves, Tracey Sutton, Eric J. Warrant, Sönke Johnsen

Marine & Environmental Sciences Faculty Articles

Eyes in low-light environments typically must balance sensitivity and spatial resolution. Vertebrate eyes with large "pixels" (e.g., retinal ganglion cells with inputs from many photoreceptors) will be sensitive but provide coarse vision. Small pixels can render finer detail, but each pixel will gather less light, and thus have poor signal relative-to-noise, leading to lower contrast sensitivity. This balance is particularly critical in oceanic species at mesopelagic depths (200–1000 m) because they experience low light and live in a medium that significantly attenuates contrast. Depending on the spatial frequency and inherent contrast of a pattern being viewed, the viewer’s pupil size …

Environmental And Occupational Health Risks: Educating Undergraduate (Adn-Bsn) Nursing Students For Safer Practice, Dorinda A. Mercado

Doctor of Nursing Practice (DNP) Projects

Background: Globally, adverse health effects, including deaths and disabilities, occur from living or working in unhealthy domains where exposure to environmental and occupational hazards exists. A multitude of these hazards are present in clinical settings in the healthcare environment where nurses care for patients and risk ongoing exposures to toxic substances.

Problem: Environmental and occupational health education is rarely included in the standard undergraduate nursing curriculum, contributing to a deficit among nurses in environmental health awareness and knowledge.

Methods: The study design was a pre/post evaluation of a single cohort (n=32) of undergraduate nursing students to assess environmental and occupational …

Variant Characterization Of A Representative Large Pedigree Suggests “Variant Risk Clusters” Convey Varying Predisposition Of Risk To Lynch Syndrome, Mouadh Barbirou, Amanda A. Miller, Amel Mezlini, Balkiss Bouhaouala-Zahar, Peter J. Tonellato

Department of Medical Oncology Faculty Papers

Recently, worldwide incidences of young adult aggressive colorectal cancer (CRC) have rapidly increased. Of these incidences diagnosed as familial Lynch syndrome (LS) CRC, outcomes are extremely poor. In this study, we seek novel familial germline variants from a large pedigree Tunisian family with 12 LS-affected individuals to identify putative germline variants associated with varying risk of LS. Whole-genome sequencing analysis was performed to identify known and novel germline variants shared between affected and non-affected pedigree members. SNPs, indels, and structural variants (SVs) were computationally identified, and their oncological influence was predicted using the Genetic Association of Complex Diseases and Disorders, …

Targeted Sequencing Of The Panicum Miliaceum Gene Space And Genotyping Of Variant Sites From Population Genetics Studies, Combined In A Single Assay, As A Tool For Broomcorn Millet Assisted Breeding, Gabriele Magris, Serena Foria, Silvano Ciani, Dipak K. Santra, Ombretta Polenghi, Virna Cerne, Michele Morgante, Gabriele Di Gaspero

Department of Agronomy and Horticulture: Faculty Publications

Broomcorn millet (Panicum miliaceum L.) is a prehistorical cereal, today cultivated as a minor crop with low yields but with a renewed interest for its high water use effciency and gluten-free grains. To reverse the downward trend in broomcorn millet cultivation, the crop needs genetic improvement and creation of novel genetic variation to increase productivity. In order to facilitate genomics-assisted breeding, we designed a reduced representation genome-sequencing assay that investigates 1.8% of the nuclear DNA in a targeted and reproducible way, with an intensity of genomic sampling that is a direct function of local recombination rate. We used this …

The S9 Model: A Comprehensive Framework For Conceptualizing Student Suicidality, Katherine C. Wilson

Dissertations, 2020-current

This dissertation introduces the S9 Model of Suicidality, an innovative framework for conceptualizing and understanding suicidality among college students. The S9 Model integrates biological, psychological, ecological, and sociocultural dimensions of suicidality into a comprehensive approach to help inform prevention, intervention, and postvention on college campuses. Drawing from empirical research, the history of suicidology, relevant psychological theories, and insights from mental health practitioners, this model encapsulates a holistic view of suicidality, considering key factors like genetic predispositions, neurobiological processes, cognitive function, psychosocial stressors, cultural norms, societal expectations, and broader ecological contexts.

The model’s tripartite approach, focusing on the ontological, ecological, and …

The Directional Effect Of Target Position On Spatial Selective Auditory Attention, Heesung Park

Dissertations, 2020-current

Spatial selective auditory attention plays a crucial role in listening in a mixture of competing speech sounds. Previous neuroimaging studies have reported alpha band neural activity modulated by auditory attention, along with the alpha lateralization corresponding to attentional focus. A greater cortical representation of the attended speech envelope compared to the ignored speech envelope was also found, a phenomenon known as 'neural speech tracking’. However, little is known about the neural activities when attentional focus is directed on speech sounds from behind the listener, even though understanding speech from behind is a common and essential aspect of daily life. The …

Lvpt: Lazy Velocity Pseudotime Inference Method, Shuainan Mao, Jiajia Liu, Weiling Zhao, Xiaobo Zhou

Faculty, Staff and Student Publications

The emergence of RNA velocity has enriched our understanding of the dynamic transcriptional landscape within individual cells. In light of this breakthrough, we embarked on integrating RNA velocity with cellular pseudotime inference, aiming to improve the prediction of cell orders along biological trajectories beyond existing methods. Here, we developed LVPT, a novel method for pseudotime and trajectory inference. LVPT introduces a lazy probability to indicate the probability that the cell stays in the original state and calculates the transition matrix based on RNA velocity to provide the probability and direction of cell differentiation. LVPT shows better and comparable performance of …

Hepatitis A Virus And Hepatitis E Virus As Food- And Waterborne Pathogens—Transmission Routes And Methods For Detection In Food, Katalin Nemes, Sofia Persson, Magnus Simonsson

Faculty, Staff and Student Publications

Foodborne viruses are an important threat to food safety and public health. Globally, there are approximately 5 million cases of acute viral hepatitis due to hepatitis A virus (HAV) and hepatitis E virus (HEV) every year. HAV is responsible for numerous food-related viral outbreaks worldwide, while HEV is an emerging pathogen with a global health burden. The reported HEV cases in Europe have increased tenfold in the last 20 years due to its zoonotic transmission through the consumption of infected meat or meat products. HEV is considered the most common cause of acute viral hepatitis worldwide currently. This review focuses …

Characterizing Cancer Metabolism From Bulk And Single-Cell Rna-Seq Data Using Metaflux, Yuefan Huang, Vakul Mohanty, Merve Dede, Kyle Tsai, May Daher, Li Li, Katayoun Rezvani, Ken Chen

Faculty, Staff and Student Publications

Cells often alter metabolic strategies under nutrient-deprived conditions to support their survival and growth. Characterizing metabolic reprogramming in the tumor microenvironment (TME) is of emerging importance in cancer research and patient care. However, recent technologies only measure a subset of metabolites and cannot provide in situ measurements. Computational methods such as flux balance analysis (FBA) have been developed to estimate metabolic flux from bulk RNA-seq data and can potentially be extended to single-cell RNA-seq (scRNA-seq) data. However, it is unclear how reliable current methods are, particularly in TME characterization. Here, we present a computational framework METAFlux (METAbolic Flux balance analysis) …

Pediatric Experience And Outcomes From The First Single-Vault Compact Proton Therapy Center, Stephanie M Perkins, Sabrina Prime, Michael Watts, Jiayi Huang, Tianyu Zhao

2020-Current year OA Pubs

The first single-vault compact proton therapy center opened in 2013, utilizing a gantry-mounted synchrocylotron. The center was placed within a large academic radiation oncology department with a high priority for pediatric cancer care. Here we performed a retrospective study of pediatric (≤21 years) patients treated with proton therapy at our institution between 2013-2022. Patient, tumor, and treatment characteristics were obtained including race, socioeconomic status, insurance type, distance travelled, need for anesthesia, and outside referrals for proton therapy. In total, 250 pediatric patients were treated with proton therapy comprising 18% of our proton patient volume. Median follow-up was 3.1 years, 38.4% …

Mutation-Induced Changes In The Stability, B-Cell Epitope, And Antigenicity Of The Sars-Cov-2 Variant Spike Protein: A Comparative Computational Stud, Nira Meirita Wijayanti, Muhammad Hermawan Widyananda, Lailil Muflikhah, Nashi Widodo

Karbala International Journal of Modern Science

The spike (S) protein is a major antigenicity site that targets neutralizing antibodies and drugs. The growing number of S protein mutations has become a severe problem for developing effective vaccines. Here, we investigated four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that were the most infectious and widespread during the COVID-19 pandemic to determine the trends and patterns of mutation-induced changes in the stability, B-cell epitope, and antigenicity of the SARS-CoV-2 S protein. The data showed that the Beta and Gamma variants had three mutations on the receptor-binding domain (RBD), which is the specific site on the S …

2023 Summer Experience Program Abstracts, The University Of Texas Md Anderson Cancer Center

Summer Experience 2023

No abstract provided.

The Devil You Know And The Devil You Don’T: Current Status And Challenges Of Bovine Tuberculosis Eradication In The United States, Daniel J. O'Brien, Tyler C. Thacker, Liliana C.M. Salvador, Anthony G. Duffiney, Suelee Robbe‑Austerman, Mark S. Camacho, Jason E. Lombard, Mitchell V. Palmer

United States Department of Agriculture Wildlife Services: Staff Publications

Having entered into its second century, the eradication program for bovine tuberculosis (bTB, caused by Mycobacterium bovis) in the United States of America occupies a position both enviable and daunting. Excepting four counties in Michigan comprising only 6109 km2 (0.06% of US land area) classified as Modified Accredited, as of April 2022 the entire country was considered Accredited Free of bTB by the US Department of Agriculture for cattle and bison. On the surface, the now well-described circumstances of endemic bTB in Michigan, where white-tailed deer (Odocoileus virginianus) serve as a free-ranging wildlife maintenance host, may appear to be …

Common-Pool Resource Management And Conflict Resolution: A Case Study Of Two Self-Governed Irrigation Schemes In Ntcheu, Malawi, George Kasch

Capstone Collection

Contrary to conventional common-pool resource (CPR) theory – where it is presumed that strong central states must be the primary actors in regulating the commons – self-governed CPR theory is a method that enables the appropriators themselves to be the primary actors in designing and managing a given CPR. Irrigation systems are one on the most common examples of CPR sharing. Using Elinor Ostrom’s theory on self-governed CPR management and her Eight Design Principles, I examine the mechanisms by which two neighboring small-scale irrigation schemes in rural Malawi manage and govern common-pool water resources to contrast intra-scheme functions and the …

Medical School Watercooler Newsletter - August 11, 2023, Lindsey Lyle

Watercooler Newsletter

This is the August 11, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Register now: Tools for teaching in medical education
• Meet a Med Student: Ben Loftis
• Basic medical sciences student presents research at international conference
• Pre-orientation course prepares medical students for academic success

Simultaneous Multifunctional Transcriptome Engineering By Crispr Rna Scaffold., Zukai Liu, Nathaniel L. Jillette, Paul Robson, Albert Cheng

Faculty Research 2023

RNA processing and metabolism are subjected to precise regulation in the cell to ensure integrity and functions of RNA. Though targeted RNA engineering has become feasible with the discovery and engineering of the CRISPR-Cas13 system, simultaneous modulation of different RNA processing steps remains unavailable. In addition, off-target events resulting from effectors fused with dCas13 limit its application. Here we developed a novel platform, Combinatorial RNA Engineering via Scaffold Tagged gRNA (CREST), which can simultaneously execute multiple RNA modulation functions on different RNA targets. In CREST, RNA scaffolds are appended to the 3' end of Cas13 gRNA and their cognate RNA …

Clemson Commencement Program, August 2023, Clemson University

Clemson Commencement Programs

No abstract provided.

Resource Assessment Report For Western Australian Salmon In Western Australia, Rodney Duffy Dr., Bianca Brooks, Alex Hesp, Amber Quinn, Blaine Hodgson, Marcus Newman

Fisheries Research Reports

This document provides a cumulative description and assessment of the Western Australian Salmon Resource (Resource) and all fishing activities (i.e., fisheries / fishing sectors) affecting this Resource in WA. The overall Resource comprises a single species, Western Australian salmon, caught within WA, in both the WCB and SCB. This species is primarily captured during the annual autumn ‘salmon run’ by recreational fishers and commercial beach seine fishers that operate on the South Coast. The report contains information relevant to assist the assessment of the Resource against Environment Protection and Biodiversity Conservation (EPBC) Act export approval requirements / the Marine Stewardship …

Dna Methylation Networks Underlying Mammalian Traits, Amin Haghani

Department of Animal Science: Faculty Publications

INTRODUCTION: Comparative epigenomics is an emerging field that combines epigenetic signatures with phylogenetic relationships to elucidate species characteristics such as maximum life span. For this study, we generated cytosine DNA methylation (DNAm) profiles (n = 15,456) from 348mammalian species using amethylation array platform that targets highly conserved cytosines.

RATIONALE: Nature has evolved mammalian species of greatly differing life spans. To resolve the relationship ofDNAmwith maximum life span and phylogeny, we performed a largescale cross-species unsupervised analysis. Comparative studies in many species enables the identification of epigenetic correlates of maximum life span and other traits.

RESULTS: We …

Uab Graduate Built An Anatomy Study Hub For Her Master's Degree. Now In Med School, She Is Putting It To Use., Staff

Browse All News

No abstract provided.

Improving Health Outcomes Among Patients With Chf Through Implementation Of Telehealth Depression Screening And Chf Symptom Management, Akudo Udodiri Unanwa

Doctor of Nursing Practice (DNP) Projects

Abstract

Background: Comorbid congestive heart failure (CHF) and depressive disorder is a leading cause of mortality globally. Despite effective detection and therapeutic options, 30-day hospital readmission rates for CHF patients remain high, with patients experiencing adverse clinical outcomes and poorer quality of life. Depression is identified as a common comorbidity among CHF patients that may negatively impact patient self-care and adherence to a CHF treatment plan.

Problem: Telehealth applications are an increasingly utilized approach to healthcare delivery that enhances timely access to healthcare services by reducing physical proximity and transportation barriers to care. Currently, telehealth screening for CHF in the …

The Plastic Pandemic: Examining Surgical Face Mask Degradation In The Marine Environment In Times Of Covid-19, Christopher J. Mayer

All HCAS Student Capstones, Theses, and Dissertations

The development and use of single-use plastics skyrocketed with the onset of the COVID-19 pandemic in 2020. With the support of world governments, manufacturing companies exponentially increased their output of personal protective equipment (PPE), and wearing surgical grade face masks became a ubiquitous aspect of reopening public society as they proved to significantly reduce the spread of the SARS-CoV-2 virus. Over the course of the pandemic, however, environmental researchers began taking note of the improper disposal and increased waste of face masks and other pandemic-associated PPE throughout a wide range of environments.

This study assessed metrics of degradation of black …

August 11, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Evaluating The Effects Of Linens On Stereotactic Body Radiation Therapy Lung Plans And Their Dosimetric Effects On Skin Dose Calculations Using A Phantom, Alison Simeo

Masters Projects

Introduction

Lung cancer remains the leading cause of death in the United States, necessitating effective treatment options. Radiation therapy has emerged as a prominent treatment modality, with stereotactic body radiation therapy (SBRT) gaining popularity. However, the use of linen coverings during treatment should be considered when calculating skin dose. This study aims to evaluate the impact of linen materials on skin dose during SBRT lung treatments. Understanding the dosimetric effects of linen coverings is critical for optimizing treatment outcomes and ensuring patient safety.

Methods

This study aimed to evaluate the effects of linen materials on the skin dose during stereotactic …

Design And Synthesis Of Small Molecule Drugs For Cns Disorders, Kirsten T. Tolentino

Theses & Dissertations

Dopamine (DA) is an important neurotransmitter for the regulation and long-term function of the central nervous system (CNS). DA binds to Dopamine Receptors (DR) to stimulate or inhibit adenyl cyclase production to further elicit a pharmacological response. DRs were cloned, and it was determined that there are two families separated by their function and five total subtypes distinguished by their amino acid structure. The Dopamine 4 receptor (D4R) is the second least studied subtype but has high expression in the frontal cortex, amygdala, hippocampus, hypothalamus, globus pallidus, substantia nigra pars reticula, and thalamus. Dopamine signaling and transmission, especially in the …