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The Atm-E6ap-Mastl Axis Mediates Dna Damage Checkpoint Recovery, Yanqiu Li, Feifei Wang, Xin Li, Ling Wang, Zheng Yang, Zhongsheng You, Aimin Peng

2020-Current year OA Pubs

Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage. In this study, we discovered the upregulated protein level of MASTL kinase hours after DNA damage. MASTL promotes cell cycle progression by preventing PP2A/B55-catalyzed dephosphorylation of CDK substrates. DNA damage-induced MASTL upregulation was caused by decreased protein degradation, and was unique among mitotic kinases. We identified E6AP as the E3 ubiquitin ligase that mediated MASTL degradation. MASTL degradation was inhibited upon DNA damage as a result of the dissociation of …

Hiv-1 Vpu Protein Forms Stable Oligomers In Aqueous Solution Via Its Transmembrane Domain Self-Association, Saman Majeed, Lan Dang, Md Majharul Islam, Olamide Ishola, Peter P Borbat, Steven J Ludtke, Elka R Georgieva

Faculty, Staff and Students Publications

We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a single-pass membrane protein. Previous observations show that this protein forms stable oligomers in aqueous solution, but details about these oligomers still remain obscure. This is an interesting and rather unique observation, as the number of proteins transitioning between soluble and membrane embedded states is limited. In this study we made use of protein engineering, size exclusion chromatography, cryoEM and electron paramagnetic resonance (EPR) spectroscopy to better elucidate the nature of the soluble oligomers. …

Development Of Antiviral Peptidomimetics, Songyi Xue

USF Tampa Graduate Theses and Dissertations

Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases. As a result, modulation of PPIs has been recognized as one of the most promising strategies to develop the novel drugs. Peptide modulators always exhibit higher specificity and affinities with targets than small compounds or monoclonal antibodies, but their broad medicinal effectiveness is constrained by their poor bioavailability and biostability. Peptidomimetics, which have been developed to mimic the structure as well as function of bioactive peptides and proteins, have shown excellent potential in protein surface mimicry and …

Queering Feminism: Rejecting Imperialist Methods Of Silencing, Mikayla Burress

sprinkle: an undergraduate journal of feminist and queer studies

No abstract provided.

A Woman Born Twice: Esther Greenwood’S Reconstruction Of The Female Identity In A Pervasively Patriarchal 1950’S America, Taylor Steinbeck

sprinkle: an undergraduate journal of feminist and queer studies

No abstract provided.

Binary Ever After: Gender Representation Of Non-Human & Non-Animal Characters In Disney/Pixar’S Inside Out, Sarah Hethershaw

sprinkle: an undergraduate journal of feminist and queer studies

No abstract provided.

Where Does Sexual Orientation Come From? Essentialism, Social Constructivism, And The Limits Of Existing Epigenetic Research, Matt Klepfer

sprinkle: an undergraduate journal of feminist and queer studies

No abstract provided.

Medicating Gender, Emma Hahn

sprinkle: an undergraduate journal of feminist and queer studies

No abstract provided.

Revolutionizing Space: A Case Study On Accessibility And Comfort, Jennifer Macmartin

sprinkle: an undergraduate journal of feminist and queer studies

Influenced by a dynamic and revolutionary crip theory, this piece seeks to operationalize the combination of crip theory/disability studies and intersectional feminist praxis. Dis/ability is consistently disregarded as a central social identity, as the world has been literally built and maintained by (temporarily) able-bodied people with the intent to accommodate able-bodied people’s needs and comfort. DeafSpace, a revolutionary project prioritizing deaf people’s needs and comfort, serves as a case study for potential revolutionary architectural projects that focus on dis/ability accommodation, accessibility, and comfort. However, in seeking additional solutions to this issue, we must be conscious of tokenizing the experiences of …

Exploiting Non-Western Women In Media Representations, Gabrielle Miller

sprinkle: an undergraduate journal of feminist and queer studies

Media representations and advertisements serve as visual mediums through which cultural values are projected and reinforced. Western capitalism relies on Eurocentric media representations that exploit perceived differences of non-white and non-western cultures to sell western products. This paper analyzes recent advertisements from Kellogg’s and Suit Supply as examples of media representations that employ Eurocentric perspectives of non-western cultures to uphold white masculinist and colonial power structures. Therefore, I suggest that the non- western cultures in the Kellogg’s and Suit Supply advertisements exist within a western capitalist vacuum. This way of consuming and representing serves to reinforce western ways of knowing …

A Pre-Medical Student’S Reconciliation Of Feminist Narratives Regarding Women’S Health: A Consideration Of Perspectives On Childbirth In The U.S., Laura Clayton

sprinkle: an undergraduate journal of feminist and queer studies

Many feminists argue that one major negative aspect of reproductive healthcare in the U.S. is the common over-medicalization of women during childbirth, including potentially unnecessary procedures such as cesarean-section and episiotomy. As a solution, they advocate for increased involvement of midwives in childbirth practices, as midwives allow women to give birth at home with minimal medical intervention. This paper analyzes the benefits of midwifery as well as the current increased risk associated with homebirth in the U.S. Additionally, it questions the damaging stigma associated with assumptions of cesarean-section as a suboptimal outcome. A false dichotomy has developed in our culture …

Rural Medical Scholars Program: Filling The Gap For Health-Care And Public Health Leaders In Mississippi, Ann Sansing, David R. Buys, Marion W. Evans Phd, Mches, Laura Downey, Jasmine Harris-Speight

Journal of Public Health in the Deep South

The Rural Medical & Science Scholars program aims to help rising high school seniors determine if they want to pursue health-related careers. The program shapes students’ interest in and understanding of medicine, health-related disciplines, and other science, technology, engineering, and mathematics (STEM) fields. The program combines didactic, observational, and practical learning during a summer semester. Participants earn seven college credits to jumpstart a health or STEM career. We report on descriptive statistics since the program’s inception in 1998. The program has matriculated 401 students, of whom approximately 71% have chosen health-related careers in nursing, physical or occupational therapy, dentistry, pharmacy, …

Maternal, Child, And Parenting Factors Associated With Obesity Among Pre-Kindergarten Children In Mississippi, Jerome R. Kolbo

Journal of Public Health in the Deep South

Background: Obesity among children and youth has been consistently assessed among public school students in Mississippi since 2005. Significant declines in the prevalence of obesity among elementary students over the past decade suggest that changes may be occurring prior to entry into public school. Purpose: The purpose was to collect anthropometric data on a weighted, representative sample of children ages 3 to 5 years in licensed childcare facilities across Mississippi, and to correlate maternal, child, and parenting characteristics to obesity. Methods: The Body Mass Index was calculated using measured height and weight data. Results: A total of 14.12% of the …

Remaining In The Workforce After Motherhood: Does The Family Medical Leave Act Play A Role In The Decisions Of Mississippi Mothers?, Danielle Fastring

Journal of Public Health in the Deep South

Background: Increased maternity leave has been shown to have a positive impact on maternal and child health, and to increase the length of time mothers breastfeed their infants. After childbirth, working women must decide if and when they will return to the workforce. Purpose: To determine the impact of current U.S. family leave policies on Mississippi mothers’ decisions to return to work after the birth of their first child. Methods: A survey was developed to collect information about factors influencing mothers’ decisions to return to work after the birth of their first child. The survey collected study eligibility information, demographics, …

The Col27a1 And Col11a1 Gene Variants Are Not Associated With The Susceptibility To Anterior Cruciate Ligament Rupture In Polish Athletes, Zhuo Sun, Aleksandra Bojarczuk, Pawel Cieszczyk

Baltic Journal of Health and Physical Activity

Introduction: Sports injuries are the most common cause of anterior cruciate ligament (ACL) ruptures. Previous research has demonstrated links between some of the COL27A1 and COL11A1 genetic variants and musculoskeletal soft tissue injuries. However, no previous research has investigated the COL27A1 rs1570460 and the COL11A1 rs3753841 in the context of ACL rupture in any population. Thus, our study aimed to assess the association between specific single nucleotide polymorphisms (SNPs), i.e., COL27A1 rs946053 and COL11A1 rs3753841, and the occurrence of ACL injury (ACL-I) in a cohort of Polish athletes. Methods: The study enrolled 233 athletes with ACL-I (161 males and …

Multi-Species Host Use By The Parasitoid Fly Ormia Lineifrons, Kyle J. Rogers, Oliver M. Beckers

Faculty & Staff Research and Creative Activity

Antagonistic species relationships such as parasitoid/host interactions lead to evolutionary arms races between species. Many parasitoids use more than one host species, requiring the parasitoid to adapt to multiple hosts, sometimes being the leader or the follower in the evolutionary back-and-forth between species. Thus, multi-species interactions are dynamic and show temporary evolutionary outcomes at a given point in time. We investigated the interactions of the multivoltine parasitoid fly Ormia lineifrons that uses different katydid hosts for each of its fly generations sequentially over time. We hypothesized that this fly is adapted to utilizing all hosts equally well for the population …

Center For Biological Diversit V. Epa

2023 Decisions

Agency

The Rider (2023-09-05), Natalie Lapsley

The Rider Archives

Vol.9 No.2

Neighborhood Disadvantage And Neural Correlates Of Threat And Reward Processing In Survivors Of Recent Trauma, E. Kate Webb, Timothy D. Ely, Grace E. Rowland, Lauren A. M Lebois, Sanne J. H Van Rooij, Steven E. Bruce, Tanja Jovanovic, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher A. Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Robert A. Swor, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Paulina Sergot, Leon D. Sanchez, Ronald C. Kessler, Karestan C. Koenen, Samuel A. Mclean, Jennifer S. Stevens, Kerry J. Ressler, Nathaniel G. Harnett

Emergency Medicine Articles

IMPORTANCE: Differences in neighborhood socioeconomic characteristics are important considerations in understanding differences in risk vs resilience in mental health. Neighborhood disadvantage is associated with alterations in the function and structure of threat neurocircuitry.

OBJECTIVE: To investigate associations of neighborhood disadvantage with white and gray matter and neural reactivity to positive and negative stimuli in the context of trauma exposure.

DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, survivors of trauma who completed sociodemographic and posttraumatic symptom assessments and neuroimaging were recruited as part of the Advancing Understanding of Recovery After Trauma (AURORA) study between September 2017 and June 2021. Data …

Gardner-Webb Alumna Dr. Carrie Mae Long Receives Prestigious Award, Office Of University Communications

Gardner-Webb NewsCenter Archive

Dr. Carrie Mae Long, a 2011 Gardner-Webb University alumna with a degree in biology, is the winner of the Pathogens 2022 Young Investigator Award (https://www.mdpi.com/about/announcements/6053). Pathogens, an international, peerreviewed, open access journal, presents this honor annually to recognize excellence in the field.

Chem 244a-005: Organic Chemistry Lab, Mustansar Hussain

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 244a-101-103: Organic Chemistry Lab, Chunmeng Lu

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 221-101: Analytical Methods, Chunyan Liu

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

The Molecular Biophysics Of Extracellular Vimentin And Its Role In Pathogen–Host Interactions, Sepideh Parvanian, Leila S. Coelho-Rato, John E. Eriksson, Alison E. Patteson

Physics - All Scholarship

Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with …

Strategies For Strengthening The Resilience Of Public Health Systems For Pandemics, Disasters, And Other Emergencies, Benjamin Ryan, Mayumi Kako, Rok Fink, Perihan Şimşek, Paul Barach, Jose Acosta, Sanjaya Bhatia, Mark Brickhouse, Matthew Fendt, Alicia Fontenot, Nahuel Arenas Garcia, Shelby Garner, Abdülkadir Gunduz, D Mike Hardin, Tim Hatch, Lashonda Malrey-Horne, Makiko Macdermot, Ryoma Kayano, Joshua Mckone, Chaverle Noel, Shuhei Nomura, Jeremy Novak, Andrew Stricklin, Raymond Swienton, Ismail Tayfur, Bryan Brooks

College of Population Health Faculty Papers

OBJECTIVE: The aim of this study was to identify and prioritize strategies for strengthening public health system resilience for pandemics, disasters, and other emergencies using a scorecard approach.

METHODS: The United Nations Public Health System Resilience Scorecard (Scorecard) was applied across 5 workshops in Slovenia, Turkey, and the United States of America. The workshops focused on participants reviewing and discussing 23 questions/indicators. A Likert type scale was used for scoring with zero being the lowest and 5 the highest. The workshop scores were analyzed and discussed by participants to prioritize areas of need and develop resilience strategies. Data from all …

System And Method For Robust, Modular, Product Sensitive Monitoring And Encoding Of Quality And Safety Along The Perishable Supply Chain, Ismail Uysal, Frederick Louis Wu

USF Patents

A system and method for assessing a supply chain for a perishable product. In various embodiments, the present invention provides a quality code for a perishable product which encodes a plurality of the most important performance metrics of the cold chain for the perishable product, including food quality oriented measures such as cut-to-cool time, transportation quality and accumulated shelf-life loss, and food safety oriented measures such as most probable number range for microorganism growth into a compact, modular and simple to read format.

Tafopathies Result From Derangements In Transcriptional Regulation Of Metabolism, Jamison Maxwell Leid

Arts & Sciences Graduate Student Theses and Dissertations

Cardiogenesis and the maintenance of cardiac physiology necessitate dynamic and carefully coordinated transcription programs. Studies in a many systems – both in vitro and in vivo – have elucidated critical signaling pathways, including Bmp, Fgf, Wnt, and Notch that induce a cardiogenic transcription program, thereby driving cardiac specification and differentiation. Recently, studies have discovered additional regulation at the epigenetic level that contributes to the tight temporal and spatial control of cardiac gene expression during development. Because transcriptional regulation is essential to cardiogenesis, changes in transcriptional regulation result in developmental defects, including but not limited to CHDs, the leading inborn cause …

Biomarker-Directed Therapy In Black And White Men With Metastatic Castration-Resistant Prostate Cancer, Clara Hwang, Nicholas C. Henderson, Shih-Chun Chu, Brandon Holland, Frank C. Cackowski, Amanda B. Pilling, Albert Jang, Shoshana Rothstein, Matthew Labriola, Joseph J. Park, Alyssa Ghose, Mehmet A. Bilen, Seema Mustafa, Deepak Kilari, Michael J. Pierro, Bicky Thapa, Abhishek Tripathi, Rohan Garje, Aditya Ravindra, Vadim S. Koshkin, Erik Hernandez, Michael T. Schweizer, Andrew J. Armstrong, Rana R. Mckay, Tanya B. Dorff, Ajjai S. Alva, Pedro C. Barata

Hematology/Oncology Articles

IMPORTANCE: Black men have higher incidence and mortality from prostate cancer. Whether precision oncology disparities affect Black men with metastatic castration-resistant prostate cancer (mCRPC) is unknown.

OBJECTIVE: To compare precision medicine data and outcomes between Black and White men with mCRPC.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used data collected by the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort (PROMISE) consortium, a multi-institutional registry with linked clinicogenomic data, from April 2020 to December 2021. Participants included Black and White patients with mCRPC with molecular data. Data were analyzed from December 2021 to May 2023.

EXPOSURES: Database-reported race and …

Chem 221-001: Analytical Methods, Mustansar Hussain

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Arkansas Novice Teachers’ Perceptions Of Preparedness In Relation To Self-Efficacy Within Classroom Management, Curriculum And Instruction, And Communication With Families: A Phenomenological Study, Margaret A. Campbell

Student Theses and Dissertations

The problem addressed in this study is the decline in the number of teachers in the field of education due to teacher attrition in the first five years of teaching. Teacher attrition can be caused by several factors. The purpose of this phenomenological study was to describe the perceptions regarding overall preparedness of novice teachers in Arkansas. Ten Arkansas novice teachers were recruited. One-on-one interviews explored new teachers’ perceptions of self-efficacy in regards to classroom management, curriculum and instruction, and communication with families. The lived experiences described in each individual interview are used to further understand how certain aspects impact …