Digital Commons Network^™

Strengthening Brain Research In Africa, Abdullahi Tunde Aborode, Nike Jesutofunmi Idowu, Samuel Tundealao, Joseph Jaiyeola, Ogunware Adedayo Emmanuel

Department of Chemistry: Faculty Publications

This paper explores the emerging field of neuroscience in Africa, considering the unique genetic diversity, sociocultural determinants, and health inequalities in the continent. It presents numerous brain research initiatives, such as ABDRN, AMARI, APCDR, and H3Africa, aimed at understanding genetic and environmental factors influencing brain disorders in Africa. Despite numerous challenges like the brain drain phenomenon, inadequate infrastructure, and scarce research expertise, significant progress has been achieved. The paper proposes solutions, including international collaboration, capacity-building efforts, and policies to promote neuroscience research, to enhance the understanding of brain function and address brain-related health issues within the African context.

Appendage Abnormalities In Spiders Induced By An Alternating Temperature Protocol In The Context Of Recent Advances In Molecular Spider Embryology, Teresa Napiorkowska, Julita Templin, Pawel Napiorkowski, Mark A. Townley

Faculty Publications

In the literature there are numerous reports of developmental deformities in arthropods collected in their natural habitat. Since such teratogenically affected individuals are found purely by chance, the causes of their defects are unknown. Numerous potential physical, mechanical, chemical, and biological teratogens have been considered and tested in the laboratory. Thermal shocks, frequently used in teratological research on the spider Eratigena atrica, have led to deformities on both the prosoma and the opisthosoma. In the 2020/2021 breeding season, by applying alternating temperatures (14 °C and 32 °C, changed every 12 h) for the first 10 days of embryonic development, …

Reducing Brain Kynurenic Acid Synthesis Precludes Kynurenine-Induced Sleep Disturbances, Katherine M. Rentschler, Snezana Milosavljevic, Annalisa M. Baratta, Courtney J. Wright, Maria V. Piroli, Zachary Tentor, Homayoun Valafar, Christian O'Reilly, Ana Pocivavsek

Publications

Patients with neurocognitive disorders often battle sleep disturbances. Kynurenic acid is a tryptophan metabolite of the kynurenine pathway implicated in the pathology of these illnesses. Modest increases in kynurenic acid, an antagonist at glutamatergic and cholinergic receptors, result in cognitive impairments and sleep dysfunction. We explored the hypothesis that inhibition of the kynurenic acid synthesising enzyme, kynurenine aminotransferase II, may alleviate sleep disturbances. At the start of the light phase, adult male and female Wistar rats received systemic injections of either: (i) vehicle; (ii) kynurenine (100 mg kg−1; i.p.); (iii) the kynurenine aminotransferase II inhibitor, PF-04859989 (30 mg kg−1; s.c.); …

September 7, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Thin And Transient Meltwater Layers And False Bottoms In The Arctic Sea Ice Pack-Recent Insights On These Historically Overlooked Features, Madison M. Smith, Hélène Angot, Emelia J. Chamberlain, Elise S. Droste, Salar Karam, Morven Muilwijk, Alison L. Webb, Stephen D. Archer, Ivo Beck, Byron W. Blomquist, Jeff Bowman, Matthew Boyer, Deborah Bozzato, Melissa Chierici, Jessie Creamean, Alessandra D’Angelo, Bruno Delille, Ilker Fer, Allison A. Fong, Agneta Fransson, Niels Fuchs, Jessie Gardner, Mats A. Granskog, Clara J.M. Hoppe, Mario Hoppema, Mario Hoppmann, Thomas Mock, Sofia Muller, Oliver Müller, Marcel Nicolaus

School of Geography, Earth and Environmental Sciences

The rapid melt of snow and sea ice during the Arctic summer provides a significant source of low-salinity meltwater to the surface ocean on the local scale. The accumulation of this meltwater on, under, and around sea ice floes can result in relatively thin meltwater layers in the upper ocean. Due to the small-scale nature of these upper-ocean features, typically on the order of 1 m thick or less, they are rarely detected by standard methods, but are nevertheless pervasive and critically important in Arctic summer. Observations during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition …

Identity Development, Attraction, And Behaviour Of Heterosexually-Identified Men Who Have Sex With Men: A Scoping Review, E Andrew, S Travis, K Taylor, P Nelson, K Sandra, M Mel, D Frank, M Lauren, B Oliver, B Erin, B Adam, V Daniel, B Cara, S Paul, O Beer

School of Health Professions

No abstract provided.

Kenyon Collegian - September 7, 2023

The Kenyon Collegian

No abstract provided.

Stem Cell And Drug Delivery Systems For Promoting Angiogenesis And Myogenesis In Ischemic Limbs, Ning Gao

McKelvey School of Engineering Graduate Student Theses & Dissertations

Peripheral artery disease (PAD) is a widespread atherosclerotic disorder affecting more than 200 million people globally, with critical limb ischemia (CLI) being its most severe manifestation. Stem cell therapy has been a promising CLI treatment, but the harsh conditions in an ischemic limb, such as hypoxia, high reactive oxygen species (ROS) stress, and the lack of a support matrix, trophic factors, and nutrients, all compromise therapeutic efficacy by reducing the survival rate or function of transplanted cells. This thesis presents various biomaterial systems designed for stem cell and drug delivery to improve the cell microenvironment and promote angiogenesis and myogenesis …

Atezolizumab For Advanced Alveolar Soft Part Sarcoma, Alice P Chen, Brian A Van Tine, Et Al.

2020-Current year OA Pubs

BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a poor prognosis and no established therapy. Recently, encouraging responses to immune checkpoint inhibitors have been reported.

METHODS: We conducted an investigator-initiated, multicenter, single-group, phase 2 study of the anti-programmed death ligand 1 (PD-L1) agent atezolizumab in adult and pediatric patients with advanced ASPS. Atezolizumab was administered intravenously at a dose of 1200 mg (in patients ≥18 years of age) or 15 mg per kilogram of body weight with a 1200-mg cap (in patients <18 years of age) once every 21 days. Study end points included objective response, duration of response, and progression-free survival according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, as well as pharmacodynamic biomarkers of multistep drug action.

RESULTS: A total of 52 patients were evaluated. An objective response was observed in …

2023-09-07 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

The meeting minutes of the Institutional Animal Care and Use Committee for September 7, 2023.

Culturally Responsive Practices In Graduate Training: Challenges, Strategies, And Recommendations, Khadija Ali, Jolinpreet Dhami, Odessa Luna

The Journal of Advancing Education Practice

This paper examines three women of color perspectives on the relevance of incorporating culture and race discussions, activities, and assignments into graduate courses. The authors provide a description of their upbringing to highlight how their personal experiences shaped their perspective on culture and race in educational settings. The challenges of delivering instruction to encompass culture are discussed alongside a student’s evaluation of these barriers. In addition, instructors outline strategies they have implemented to incorporate a culturally responsive practice. Lastly, the authors present recommendations to urge other faculty members and students to use and advocate for culturally responsive practices.

Eipeck: Assessing Educators’ Pedagogical Content Knowledge For Engineering Integration In K-12, Pilar Pazos, Francisco Cima Cohuo, Jennifer Kidd, Kristie Gutierrez, Krishnanand Kaipa, Orlando Ayala

Journal of Pre-College Engineering Education Research (J-PEER)

Global efforts are underway to include engineering in pre-college curricula. In the USA, this pursuit led to the inclusion of engineering content in the most recent version of the Next Generation Science Standards that guide K-12 science. As these standards become part of the K-12 curriculum, teachers face the challenge of gaining basic engineering literacy, while developing the associated inclusive pedagogies necessary to integrate engineering content into their classrooms. In this context, teacher preparation programs can benefit from easy-to-implement tools that measure preservice teachers’ readiness to integrate engineering content in their future classrooms. This work describes the development and validation …

Medical School Watercooler Newsletter - September 6, 2023, Lindsey Lyle

Watercooler Newsletter

This is the September 6, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Meet a Med Student: Cana Brown
• USA scientists awarded national grant to study body's innate immune response to infection
• Medical student to present tick transmission research at national conference

Scents Of Place: Exploring Self, Place And Planet Through Botanical Fragrance, Jennifer L. Kitson, Donna M. Sweigart

Open Educational Resources

This learning module provides instructors with an experiential field guide for introducing students to the United Nations Inner Development Goals Framework through self-guided mindful smelling activities and reflection prompts related to botanical fragrance. The interdisciplinary nature of this module allows for use or adaptation in a wide range of courses looking for outdoor, place-based and self-guided experiential learning to explore the role of botanical fragrance for people, plants and pollinators. The overarching goal is to deepen students’ connections to their senses (and scents) of self, place and planet through exploring botanical fragrance with mindful smelling. The learning activities in this …

Smokejumper Biographies For 1956 Rookie Class, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1956.

Smokejumper Biographies For 1955 Rookie Class, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1955.

Smokejumper Biographies For 1958 Rookie Class, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1958.

Impact Of Low-Level Prenatal Alcohol Exposure And Maternal Stress On Autonomic Regulation, Jessie R. Maxwell, Jared Didomenico, Melissa H. Roberts, Lidia Enriquez Marquez, Rajani Rai, Joanne Weinberg, Sandra W. Jacobson, Julia Stephen, Ludmila N. Bakhireva

Pediatrics Research and Scholarship

BACKGROUND: Prenatal alcohol exposure (PAE) impacts the neurodevelopment of the fetus, including the infant's ability to self-regulate. Heart rate variability (HRV), that is, the beat-to-beat variability in heart rate, is a non-invasive measurement that can indicate autonomic nervous system (ANS) function/dysfunction.

METHODS: The study consisted of a subset of our ENRICH-2 cohort: 80 participants (32 PAE and 48 Controls) who had completed three visits during pregnancy. The participants completed a comprehensive assessment of PAE and other substances throughout pregnancy and assessments for stress, anxiety, and depression in the third trimester. At 24 h of age, infant HRV was assessed in …

Short-Weighting, Species Authentication, And Labeling Compliance Of Prepackaged Frozen Shrimp Sold In Grocery Stores In Southern California, Mckenna C. Rivers, Alexia B. Campbell, Chris Haneul Lee, Pragati Kapoor, Rosalee S. Hellberg

Food Science Faculty Articles and Research

Shrimp is the most-consumed seafood product in the United States; however, there is a lack of research into the extent of short-weighting and mislabeling of shrimp in the commercial marketplace. The objective of this study was to investigate frozen shrimp for Country of Origin Labeling (COOL) compliance, species authentication, acceptable market names, net weights, and percent glaze. A total of 106 frozen shrimp packages were purchased from grocery stores in Southern California. Samples were considered COOL compliant if both the procurement method and country of origin were reported at the point of sale. Species authentication and acceptable market names were …

Ap Statistics Students’ Conceptions Of Engagement And Technology In A Flipped Classroom: A Phenomenographical Study, Kimberly Gile

Doctor of Education in Instructional Technology Dissertations

The purpose of this dissertation was to study student engagement and disengagement within an AP Statistics course using flipped classroom strategies. Vygotsky’s Zone of Proximal Development and Scaffolding, Dewey’s Active Learning Theory, the Microsystem of Student Engagement in a Flipped Classroom, and the Framework for Engagement with Mathematics were the theoretical foundation for this study. A phenomenographical methodology was followed to answer the question: How do AP Statistics students experience engagement in the flipped classroom? as well as the sub questions: Which learning experiences help to engage students and why? And which learning experiences contribute to student disengagement and why? …

September 6, 2023 (Vol. 108, No.3), Daily Eastern News

Daily Eastern News: 2023-2024

No abstract provided.

Frsc 498-001: Forensic Anthropology, Sara Casado Zapico

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Smokejumper Biographies For 1957 Rookie Class, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1957.

Fs Transcript 2023-09-06, Northern Illinois University

Faculty Senate Archives

No abstract provided.

Analysis Of Factors Affecting Construction And Demolition Waste Reduction In Egypt, Ayman Ahmed Ezzat Othman, Ahmed Osama Daoud, Obas John Ebohon, Ali Bayyati

Architectural Engineering

Construction projects are associated with construction and demolition waste (CDW) generated at different stages. In Egypt’s case, the CDW problem has become a significant challenge, and the need to find sustainable solutions is overwhelming. Based on recent investigations in the literature, it was found that six main factors are affecting CDW reduction (CDWR) as follows: (1) waste-efficient materials procurement measures; (2) waste-efficient materials procurement models; (3) green materials procurement approach; (4) legislation; (5) culture & behaviour; and (6) awareness. In this study, a representative sample of Egyptian construction firms was screened to (1) investigate the applicability and effectiveness of CDWR …

Unh Hodgdon Herbarium Nears Complete Digitization Of Entire Collection, Nicholas Gosling

UNH Today Archive

No abstract provided.

Oligodendrocyte 2phatal Reveals Dynamics Of Myelin Degeneration And Repair, Timothy W. Chapman

Dartmouth College Ph.D Dissertations

Oligodendrocytes are responsible for producing myelin in the central nervous system. This lipid-rich coating along axons helps to increase action potential velocity, provide metabolic support to axons, and facilitate fine-tuning of neuronal circuitry. Demyelination and/or myelin dysfunction is widespread in neurodegenerative diseases and aging. Despite this, we know very little about how individual oligodendrocytes, or the myelin sheaths they produce, degenerate. Myelin repair, carried out by resident oligodendrocyte precursor cells (OPCs), is known to occur following myelin damage in certain contexts. We sought to investigate the cellular dynamics of oligodendrocyte degeneration and repair by developing a non-inflammatory demyelination model, combining …

Clinically Conserved Genomic Subtypes Of Gastric Adenocarcinoma, Yun Seong Jeong, Young-Gyu Eun, Sung Hwan Lee, Sang-Hee Kang, Sun Young Yim, Eui Hyun Kim, Joo Kyung Noh, Bo Hwa Sohn, Seon Rang Woo, Moonkyoo Kong, Deok Hwa Nam, Hee-Jin Jang, Hyun-Sung Lee, Shumei Song, Sang Cheul Oh, Jeeyun Lee, Jaffer A Ajani, Ju-Seog Lee

Faculty, Staff and Student Publications

Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established genomic signatures for GAC subtypes, we identified 6 clinically and molecularly distinct genomic consensus subtypes (CGSs). CGS1 have the poorest prognosis, very high stem cell characteristics, and high IGF1 expression, but low genomic alterations. CGS2 is enriched with canonical epithelial gene expression. CGS3 and CGS4 have high copy number alterations and low immune reactivity. However, CGS3 and CGS4 differ in that CGS3 has high HER2 activation, while CGS4 has high SALL4 and KRAS activation. CGS5 has the high mutation burden and moderately …

Integrating Forest Structural Diversity Measurement Into Ecological Research, Jeff W. Atkins, Parth Bhatt, Luis Carrasco, Emily Francis, James E. Garabedian, Christopher R. Hakkenberg, Brady S. Hardiman, Jinha Jung, Anil Koirala, Elizabeth A. Larue, Sungchan Oh, Gang Shao, Guofan Shao, H. H. Shugart, Anna Spiers, Atticus E.L. Stovall, Thilina D. Surasinghe, Xiaonan Tai, Lu Zhai, Tao Zhang, Keith Krause

Michigan Tech Publications

The measurement of forest structure has evolved steadily due to advances in technology, methodology, and theory. Such advances have greatly increased our capacity to describe key forest structural elements and resulted in a range of measurement approaches from traditional analog tools such as measurement tapes to highly derived and computationally intensive methods such as advanced remote sensing tools (e.g., lidar, radar). This assortment of measurement approaches results in structural metrics unique to each method, with the caveat that metrics may be biased or constrained by the measurement approach taken. While forest structural diversity (FSD) metrics foster novel research opportunities, understanding …

Attributing Equity Gaps To Course Structure In Introductory Physics, David J. Webb, Cassandra Paul

Faculty Research, Scholarly, and Creative Activity

We add to a growing literature suggesting that demographic grade gaps should be attributed to biases embedded in the courses themselves. Changes in the structure of two different introductory physics classes were made while leaving the topics covered and the level of coverage unchanged. First, a class where conceptual issues were studied before doing any complicated calculations had zero final exam grade gap between students from underrepresented racial or ethnic groups and their peers. Next, four classes that offered students a retake exam each week between the regular bi-weekly exams during the term had zero gender gap in course grades. …