Digital Commons Network^™

Global Impact Of Proteoglycan Science On Human Diseases, Christopher Xie, Liliana Schaefer, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss …

Dynamical Oceanographic Processes Impact On Reef Manta Ray Behaviour: Extreme Indian Ocean Dipole Influence On Local Internal Wave Dynamics At A Remote Tropical Atoll, Edward Robinson, Phil Hosegood, Adam Bolton

School of Biological and Marine Sciences

Physical oceanographic observations were made with subsurface, taut-line moorings at Egmont Island, a tropical atoll within the Chagos Archipelago in the central Indian Ocean, to elucidate the dynamics of near-bed cold-water intrusions implicated in driving local aggregations of reef manta rays (Mobula alfredi). Manta have been previously shown to aggregate within ‘Manta Alley’, a lipped gully at 65 m depth along the north coast, at times when the surface to bottom temperature difference was highest. We here identify the dynamical processes driving these temperature differences and shaping the foraging landscape at Egmont, and equivalent small-scale atolls, improving our understanding of …

Antioxidant Dimethyl Fumarate Temporarily But Not Chronically Improves Intracortical Microelectrode Performance, George F. Hoeferlin, Tejas Bajwa, Hannah Olivares, Jichu Zhang, Lindsey N. Druschel, Michael Sobota, Pierce E. Boucher, Jonathan L. Duncan, Jeffrey R. Capadona

Faculty Scholarship

Intracortical microelectrode arrays (MEAs) can be used in a range of applications, from basic neuroscience research to providing an intimate interface with the brain as part of a brain-computer interface (BCI) system aimed at restoring function for people living with neurological disorders or injuries. Unfortunately, MEAs tend to fail prematurely, leading to a loss in functionality for many applications. An important contributing factor in MEA failure is oxidative stress resulting from chronically inflammatory-activated microglia and macrophages releasing reactive oxygen species (ROS) around the implant site. Antioxidants offer a means for mitigating oxidative stress and improving tissue health and MEA performance. …

Excitatory Neuron-Specific Suppression Of The Integrated Stress Response Contributes To Autism-Related Phenotypes In Fragile X Syndrome, Mehdi Hooshmandi, Vijendra Sharma, Carolina Thörn Perez, Rapita Sood, Konstanze Krimbacher, Calvin Wong, Kevin C Lister, Alba Ureña Guzmán, Trevor D Bartley, Cecilia Rocha, Gilles Maussion, Emma Nadler, Patricia Margarita Roque, Ilse Gantois, Jelena Popic, Maxime Lévesque, Randal J Kaufman, Massimo Avoli, Elisenda Sanz, Karim Nader, Randi Jenssen Hagerman, Thomas M Durcan, Mauro Costa-Mattioli, Masha Prager-Khoutorsky, Jean-Claude Lacaille, Veronica Martinez-Cerdeno, Jay R Gibson, Kimberly M Huber, Nahum Sonenberg, Christos G Gkogkas, Arkady Khoutorsky

Faculty, Staff and Students Publications

Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum disorder (ASD). However, the role of a major pathway controlling protein synthesis, the integrated stress response (ISR), in ASD remains poorly understood. Here, we demonstrate that the main arm of the ISR, eIF2α phosphorylation (p-eIF2α), is suppressed in excitatory but not inhibitory neurons in a mouse model of fragile X syndrome (FXS; Fmr1−/y). We further show that the decrease in p-eIF2α is mediated via activation of the mTORC1. Genetic reduction of p-eIF2α only in excitatory neurons is sufficient to increase general protein synthesis and cause autism-like …

Hemizygous Variants In Protein Phosphatase 1 Regulatory Subunit 3f (Ppp1r3f) Are Associated With A Neurodevelopmental Disorder Characterized By Developmental Delay, Intellectual Disability And Autistic Features, Zhigang Liu, Baozhong Xin, Iris N Smith, Valerie Sency, Julia Szekely, Anna Alkelai, Alan Shuldiner, Stephanie Efthymiou, Farrah Rajabi, Stephanie Coury, Catherine A Brownstein, Sabine Rudnik-Schöneborn, Ange-Line Bruel, Julien Thevenon, Shimriet Zeidler, Parul Jayakar, Axel Schmidt, Kirsten Cremer, Hartmut Engels, Sophia O Peters, Maha S Zaki, Ruizhi Duan, Changlian Zhu, Yiran Xu, Chao Gao, Tania Sepulveda-Morales, Reza Maroofian, Issam A Alkhawaja, Mariam Khawaja, Hunaida Alhalasah, Henry Houlden, Jill A Madden, Valentina Turchetti, Dana Marafi, Pankaj B Agrawal, Ulrich Schatz, Ari Rotenberg, Joshua Rotenberg, Grazia M S Mancini, Somayeh Bakhtiari, Michael Kruer, Isabelle Thiffault, Steffen Hirsch, Maja Hempel, Lara G Stühn, Tobias B Haack, Jennifer E Posey, James R Lupski, Hyunpil Lee, Nicholas B Sarn, Charis Eng, Claudia Gonzaga-Jauregui, Bin Zhang, Heng Wang

Faculty, Staff and Students Publications

Protein phosphatase 1 regulatory subunit 3F (PPP1R3F) is a member of the glycogen targeting subunits (GTSs), which belong to the large group of regulatory subunits of protein phosphatase 1 (PP1), a major eukaryotic serine/threonine protein phosphatase that regulates diverse cellular processes. Here, we describe the identification of hemizygous variants in PPP1R3F associated with a novel X-linked recessive neurodevelopmental disorder in 13 unrelated individuals. This disorder is characterized by developmental delay, mild intellectual disability, neurobehavioral issues such as autism spectrum disorder, seizures and other neurological findings including tone, gait and cerebellar abnormalities. PPP1R3F variants segregated with disease in affected hemizygous males …

Light And Temperature Drive The Distribution Of Mesophotic Benthic Communities In The Central Indian Ocean, Clara Diaz, Kerry L. Howell, Edward Robinson, Philip Hosegood, Adam Bolton, Peter Ganderton, Peter Arber, Martin J. Attrill, Nicola L. Foster

School of Biological and Marine Sciences

Aim Research on mesophotic coral ecosystems (MCEs) has increased exponentially in recent decades, and the significance of this ecosystem has been recognised both in terms of biodiversity and distribution. However, this research has mostly focussed on corals and is globally sporadic, with the Indian Ocean remaining largely unexplored and overall MCEs under protected. Hence, baseline data on MCE benthic communities is lacking, but nonetheless essential for developing adequate management strategies. Here, we assess the variation in diversity and community structure of MCEs along the depth gradient and among sites in the Indian Ocean and the environmental parameters that are potentially …

Multivariate Gwas Of Alzheimer's Disease Csf Biomarker Profiles Implies Grin2d In Synaptic Functioning, Alexander Neumann, Jigyasha Timsina, Thomas W Marsh, Priyanka Gorijala, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

BACKGROUND: Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF) biomarkers may aid in gene discovery and we previously demonstrated that six CSF biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-40, and neurogranin) cluster into five principal components (PC), each representing statistically independent biological processes. Here, we aimed to (1) identify common genetic variants associated with these CSF profiles, (2) assess the role of associated variants in AD pathophysiology, and (3) explore potential sex differences.

METHODS: We performed GWAS for each of the five biomarker PCs in two multi-center studies (EMIF-AD …

“A Word For Nature”: A Reflection On A Contemplative Teacher-Training Course In The Desert, Netta Baryosef-Paz, Nirit Assaf

Journal of Contemplative and Holistic Education

This paper reflects on an interdisciplinary, environmental, and contemplative course the authors taught at Kibbutzim College of Education in Tel Aviv. Entitled “I am in Nature,” the course was co-taught by an ecologist and a literary scholar. It included a two-day base camping and hiking experience in the Negev Desert and three on-campus meetings. The students read Nature Writing and Ecopoetry, practiced guided mindfulness meditations in the field, and kept contemplative-writing journals. In this community voices piece, we offer an innovative pedagogy for higher education that centers on the integration of the learner’s mind, body, and heart through interdisciplinary, contemplative, …

Smart Sounding Table Using Adaptive Neuro-Fuzzy Inference System, Osman Ünal, Nuri Akkaş

Journal of Marine Science and Technology–Taiwan

Marine engineers measure the liquid level (sounding depth) to calculate the volumetric content of a ship's tank. The sounding depth is determined using an ullage pipe located at specific points on the tanks. To estimate the accurate volume of liquid, considering the ship's trim and heel conditions, engineers use a tank table (sounding table) consisting of hundreds of pages. However, this method is time-consuming and lacks intermediate values for sounding depth, trim, and heel. Ship designers recommend to use linear interpolation for intermediate values, yet this process is also time-consuming. This paper proposes the implementation of an Adaptive Neuro-Fuzzy Inference …

Case Study Of Coastal Erosion And Measures At Kezailiao Coast, Taiwan, Tai-Wen Hsu, Yi-Tse Tu, Jen-Yi Chang

Journal of Marine Science and Technology–Taiwan

This paper examines major factors of coastal erosion and measures against beach erosion at Kezailiao Coast, Taiwan. Typical examples of coastal erosion due to natural or man-made factors are reviewed. Case studies of countermeasure for beach erosion are addressed. We further analyze and discuss historical shoreline and coastal cliff recession as a result of the attack of storm surges and waves. The coastline mainly made up of cliffs (2-3m high), made of soft, easily eroded boulder sand and clay. In total, 3km of land have been lost since 1951, including villages and farm buildings. The most important impacts of beach …

Wearable Sensor-Based Walkability Assessment At Ferry Terminal Using Machine Learning: A Case Study Of Mokpo, Korea, Jungyeon Choi, Hwayoung Kim

Journal of Marine Science and Technology–Taiwan

Walkability assessments are becoming more popular, as walking offers numerous health, environmental, and economic benefits to communities. However, previous studies on ferry terminal walkability assessment have been inadequate. This study aimed to develop a wearable sensor system to automatically assess walkability at ferry terminals without conducting surveys. We applied seven machine learning (ML) classifiers to detect different walking environments, including flat ground (FG), downhill slope (DS), uphill slope (US), and uneven surface (UE). The ML models were evaluated across different combinations of classes: 2-class (FG vs. UE), 3-class (U) (FG vs. US vs. UE), 3-class (D) (FG vs. DS vs. …

Application Of Blockchain Technology In Aquaculture Management, Yu-Jen Pan, Hsin-Pei Shieh

Journal of Marine Science and Technology–Taiwan

In recent years, food safety has become a growing concern in Taiwanese society. To ensure efficient management of the supply chain within the L Aquatic Products company, it is imperative to employ reliable technical support in establishing an effective traceability management system. The traceability of products can provide managers with valuable insight into the intricacies of the supply chain. By establishing a dependable food traceability system, brand trust can be strengthened, and consumers can inquire about the movement of aquatic products within the supply chain. Blockchain technology offers features such as traceability, accountability, transparency, reliability, trust, privacy, and security, making …

Production Of Ground Granulated Blast-Furnace Slag Cement: Energy And Carbon Reduction Efficiency Of Cement-Grinding System, Kuan-Hung Lin, Chung-Chia Yang

Journal of Marine Science and Technology–Taiwan

This study used clinker, ground granulated blast-furnace slag (GGBS), and gypsum in a cement-grinding system to produce GGBS cement (GCE). Gypsum was used as the alkaline activator to modify the surface area of GCE and increase its compressive strength. The results revealed that the use of the gypsum activator and the modification of the surface area of GCE effectively increased the formerly inadequate compressive strength of GCE (GGBS > 60%) in the early stage. In addition, energy consumption data were obtained during the production of GCE and Portland cement (PCE) by the cement-grinding system. The calculations concerning the production proportions indicated …

Web-Based Duplicate Records Detection With Arabic Language Enhancement, Azza Abd Al-Elah Higazy,, Amany M. Sarhan,, Tarek E. El-Tobely

Journal of Engineering Research

Sharing data between organizations has growing importance in many data mining projects. Data from various heterogeneous sources often has to be linked and aggregated in order to improve data quality. The importance of data accuracy and quality has increased with the explosion of data size. The first step to ensure the data accuracy is to make sure that each real world object is represented once and only once in a certain dataset which called Duplicate Record Detection (DRD). These data inaccuracy problems exist due to due to several factors including spelling, typographical and pronunciation variation, dialects and special vowel and …

Te Integration Of Water Hydrodynamics Modelling And Remote Sensing Data To Improve The Water Circulation Of Lake Manzala, Egypt, M. A. Bek, , Sameh B. Elkafrawy, , I. S. Lowndes,, D. M. Hargreaves

Journal of Engineering Research

This paper presents the preliminary results of the application of the ocean model (FVCOM) to replicate the hydrodynamic flows experienced within Lake El-Manzala, Egypt. The construction of this model is used to characterize the ecosystem of this shallow brackish lake and assess a range of sustainable water management strategies. Lake El-Manzala is the largest of the Egyptian shallow coastal lakes on the fringe of the Mediterranean Sea. The lake currently supports 30% of the fresh water fish farm production of Egypt. In recent years the aquatic health of the lake has significantly deteriorated due to an increase in the contamination …

Breast Ironing: Analyzing The Rights Of The Girl-Child In The Context Of Cameroon’S Obligation Under International Human Rights Law, Olusola Babatunde Adegbite, Olaitan Oluwaseyi Olusegun

Buffalo Human Rights Law Review

Among the various forms of sexual violence perpetrated against the girl-child, breast ironing remains largely obscured due to its underreporting. Yet thousands of girls, especially in Sub-Saharan Africa where it is most prevalent, continue to suffer in silence. These girls are not just exposed to the immediate violence of this act, but they also carry the scar of this human rights violation for life. With the scholarly focus on the practice rather scant, the necessary legal response has also been checkmated. The goal of this article is to bring international focus to this problem by examining the practice in the …

Life Without Parole: An Eighth Amendment Analysis, Alexis Dicarlo

Buffalo Human Rights Law Review

This Article will analyze the constitutionality of life without parole under the U.S. Supreme Court’s test for categorical bans on sentencing practices. This article first addresses the cruelty of prison and how that affects individuals with life sentences specifically. Next, it will analyze life without parole under the Supreme Court’s Eighth Amendment analysis, starting with examining evolving standards of decency. In doing so, this article will address how the U.S. operates with respect to sentencing compared to the rest of the world. Importantly, it will engage in a culpability analysis, following the Supreme Court’s logic, that ultimately favors abolition of …

The Indiana Statesman, October 3, 2023, Indiana State University

Student Newspaper

Womens empowerment: Career center and MSP hosts panel; Historic rainfall sets record in N.Y.; Ukraine’s allies fret over coalition after U.S. drops aid

Overcoming Challenges In Chemical Glycosylation To Achieve Innovative Vaccine Adjuvants Possessing Enhanced Tlr4 Activity, Alessio Romerio, Ana Rita Franco, Melanie Shadrick, Mohammed Monsoor Shaik, Valentina Artusa, Alice Italia, Federico Lami, Alexei V. Demchenko, Francesco Peri

Chemistry & Biochemistry Faculty Works

Lipopolysaccharide (LPS) mimicry leading to toll-like receptor 4 (TLR4) active compounds has been so far based mainly on reproducing the lipid A portion of LPS. Our work led to a series of structurally simplified synthetic TLR4 agonists in preclinical development as vaccine adjuvants called FPs. FPs bind MD2/TLR4 similarly to lipid A, inserting the lipid chains in the MD2 lipophilic cavity. A strategy to improve FPs’ target affinity is introducing a monosaccharide unit in C6, mimicking the first sugar of the LPS core. We therefore designed a panel of FP derivatives bearing different monosaccharides in C6. We report here the …

Gardner-Webb Professor And Student Present Papers At International Meeting, Office Of University Communications

Gardner-Webb NewsCenter Archive

While exploring the Broad River, students at Gardner-Webb University might observe what looks like a rock, but it’s really a bivalved freshwater mussel or mollusk, points out Dr. David Campbell, associate professor of paleontology and chair of the Department of Natural Sciences. Clams and oysters are examples of bivalved mollusks, and he has studied various species of them since he was a senior in high school (35 years). His son, Timothy, a first-year Gardner-Webb student, is carrying on the tradition, and recently father and son presented their research at the international meeting on bivalves at Cambridge University in England.

Effect Of Preoperative Programmed Death-1 Or Programmed Death Ligand-1 Immune Check Point Inhibition On Complications After Surgery For Primary Head And Neck Cancer, Ramez Philips, Angela Alnemri, Dev Amin, Jena Patel, Michael C. Topf, Jennifer M. Johnson, Voichita Bar-Ad, Rita Axelrod, Athanassios Argiris, Christopher Fundakowski, Adam J. Luginbuhl, David M. Cognetti, Joseph M. Curry

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: There is sparse literature on the effect of preoperative immunotherapy on complications after surgery for primary head and neck squamous cell carcinoma (HNSCC). The objectives are to compare complication rates in patients receiving surgery with and without neoadjuvant immune checkpoint inhibitors (nICI) for primary HNSCC and to evaluate factors associated with increased odds of surgical complications.

METHODS: A retrospective review of patients who underwent ablation and free flap reconstruction or transoral robotic surgery (TORS) for primary HNSCC between 2017-2021 was conducted. Complications were compared between patients who underwent surgery with or without nICI before and after propensity score matching. …

Multifunctional Porous Materials For Water Purification And Remediation, Shengqian Ma, Qi Sun, Briana Aguila

USF Patents

A variety of compositions and materials are provided for water purification and remediation. The compositions including multiple functionalities for treating a variety of pollutants or contaminants. The compositions can include a porous organic polymer with one or more of a variety of functional groups for binding the contaminants and with a hierarchical pore size distribution over a range of pore sizes to facilitate enhanced removal of the contaminants. Functional groups can include one, two, or more different functional groups such as amines, halides, ammoniums, pyridiuiums, thiols, imidazoliums, salts thereof, or others. The range of pore sizes can be about 1 …

Chapter Ix — Derailed Modernization: The Ethnonationalist Phase, Messay Kebede

Ethiopian Modernization: Opportunities and Derailments

The last chapter concluded with the generalized expectation that the fall of the Derg would set in motion some form of democratization dismantling the wide-ranging restrictions of the existing socialist system, even if there was uncertainty about the real political program of the victorious Tigrean insurgents. Despite promises of democratization, it did not take long for people to realize that Ethiopia was heading for yet another version of hegemonic rule, this one replacing the class ideology of the previous regime with ethnonationalism. As though a curse were on it, Ethiopia’s modernization will once more stumble over an ideology and a …

Deleterious Mutations Predicted In The Sorghum (Sorghum Bicolor) Maturity (Ma) And Dwarf (Dw) Genes From Whole‑Genome Resequencing, Nathan P. Grant, John J. Toy, Deanna L. Funnell, Scott E. Sattler

Department of Agronomy and Horticulture: Faculty Publications

In sorghum [Sorghum bicolor (L.) Moench] the Maturity (Ma1, Ma2, Ma3, Ma4, Ma5, Ma6) and Dwarf (Dw1, Dw2, Dw3, Dw4) loci, encode genes controlling flowering time and plant height, respectively, which are critical for designing sorghum ideotypes for a maturity timeframe and a harvest method. Publicly available whole-genome resequencing data from 860 sorghum accessions was analyzed in silico to identify genomic variants at 8 of these loci (Ma1, Ma2, Ma3, Ma5, Ma6, Dw1, Dw2, Dw3) to identify novel loss …

Multi-Factor Optimization Of Bio-Methanol Production Through Gasification Process Via Statistical Methodology Coupled With Genetic Algorithm, Amin Hedayati Moghaddam, Morteza Esfandyari, Dariush Jafari, Hossein Sakhaeinia

Department of Civil and Environmental Engineering: Faculty Publications

This work innovatively explores the bio-methanol production process, conducts comprehensive analyses, develops statistical models, and optimizes operational conditions, contributing valuable insights to the field of sustainable energy production from biomass. Accordingly, bio-methanol production from biomass through gasification route was investigated and simulated using Aspen Plus software. The effects of operational parameters on energy duty of gasification reactor and the methanol production rate in syngas to methanol reactor were investigated. The parameters affecting the process performance including temperature, pressure, and steam/feed ratio were examined using the response surface methodology (RSM) by central composite design (CCD) technique. Analysis of variance (ANOVA) was …

Multi-Factor Optimization Of Bio-Methanol Production Through Gasification Process Via Statistical Methodology Coupled With Genetic Algorithm, Amin Hedayati Moghaddam, Morteza Esfandyari, Dariush Jafari, Hossein Sakhaeinia

Department of Civil and Environmental Engineering: Faculty Publications

This work innovatively explores the bio-methanol production process, conducts comprehensive analyses, develops statistical models, and optimizes operational conditions, contributing valuable insights to the field of sustainable energy production from biomass. Accordingly, bio-methanol production from biomass through gasification route was investigated and simulated using Aspen Plus software. The effects of operational parameters on energy duty of gasification reactor and the methanol production rate in syngas to methanol reactor were investigated. The parameters affecting the process performance including temperature, pressure, and steam/feed ratio were examined using the response surface methodology (RSM) by central composite design (CCD) technique. Analysis of variance (ANOVA) was …

Lung Resident Memory B Cells Maintain Allergic Ige Responses In The Respiratory Tract, Alexander James Nelson

Dissertations

Immunoglobulin E (IgE) is the primary cause of allergic asthma. Allergen-specific IgE can be detected in the airway of allergic asthma patients even in the absence of circulating IgE, suggesting that IgE can be synthesized locally in the respiratory tract. However, the source of IgE-producing B cells, as well as how IgE responses arise and persist at mucosal sites are not fully understood. To address these questions, we modeled allergic asthma in mice by repeated intranasal administration of ragweed pollen and ovalbumin (OVA). We found that allergen exposure induced the production of local IgE in the airway and formation of …

Antimicrobial Resistance And Rational Prescription Practices: Knowledge, Perceptions And Confidence Of Health Profession Interns In Uganda, Shamim Nabidda, Rogers Ssennyonjo, Joseph Atwaru, Andrew Marvin Kanyike, Shiellah Baryayaka, Kennedy Pangholi, Jonans Tusiimire

School of Nursing & Midwifery, East Africa

Background

Antimicrobial resistance (AMR) is significantly driven by misuse and overuse of antibiotics. Graduate health profession interns often prescribe antimicrobials under minimum supervision.

Objectives

This study explored the knowledge, perceptions and confidence of health profession interns in Uganda regarding AMR and rational prescription practices.

Methods

This was a cross-sectional survey employing quantitative techniques carried out between October and November 2022 at six tertiary hospitals in Uganda. Health profession interns including doctors, nurses, midwives and pharmacists were recruited as study participants. Data were collected using online Kobo toolbox software. Data analysis was performed using STATA (StataCorp) version 16. Bivariate analysis and …

Alumni Award Winners To Be Honored During Homecoming, Emily J. Schubert

News and Events (Discontinued Series)

No abstract provided.

Privacy-Preserving Federated Genome-Wide Association Studies Via Dynamic Sampling, Xinyue Wang, Leonard Dervishi, Wentao Li, Erman Ayday, Xiaoqian Jiang, Jaideep Vaidya

Faculty, Staff and Student Publications

MOTIVATION: Genome-wide association studies (GWAS) benefit from the increasing availability of genomic data and cross-institution collaborations. However, sharing data across institutional boundaries jeopardizes medical data confidentiality and patient privacy. While modern cryptographic techniques provide formal secure guarantees, the substantial communication and computational overheads hinder the practical application of large-scale collaborative GWAS.

RESULTS: This work introduces an efficient framework for conducting collaborative GWAS on distributed datasets, maintaining data privacy without compromising the accuracy of the results. We propose a novel two-step strategy aimed at reducing communication and computational overheads, and we employ iterative and sampling techniques to ensure accurate results. We …