Digital Commons Network^™

Undergraduate And Graduate Students’ Challenges: A Qualitative Study With Ondas Framework Across Multiple Disciplines And Innovative Research Methodologies, Omar Khasro Akram, Daniel José Franco, Apina Lee

The Qualitative Report

The integration levels among research methods, management, research tools, and psychology could guide the development of the ONDAS framework toward the secrets of knowledge. The research grounds on undergraduate and graduate students' challenges, with particular emphasis on the need for writing critical literature reviews and weaknesses in identifying benchmark studies to extract the research gap and main research questions, resulting in most fresh graduate students not graduating on time. Some master’s students write doctoral theses, and vice versa, confusing their identified research approach. The study utilizes desk documents to identify the main problems that most students experienced during their research, …

Characterizing The Utility Of A Near Infrared Click Beetle Luciferase For Bli Applications, Giovanni Duca

Master's Theses

Bioluminescent imaging systems (BLI) have become a valuable tool for doing real-time in vivo studies. BLI systems typically allow for the imaging of surface and subsurface level tissues but as depth increases, the resolution decreases while the signal to noise ratio increases. Deep tissue imaging is therefore a major limitation for BLI. To address this limitation there has been a consistent movement in luciferase research to create long wavelength emitting luciferases that still have a high photon emission rate. Longer wavelengths of light are able to penetrate deeper tissues due to having a lower amount of absorbance and scattering from …

Quality Of Life In Male Breast Cancer: Prospective Study Of The International Male Breast Cancer Program (Eortc10085/Tbcrc029/Big2-07/Nabcg), Carolien P Schröder, Elise Van Leeuwen-Stok, Fatima Cardoso, Barbro Linderholm, Coralie Poncet, Antonio C Wolff, Vesna Bjelic-Radisic, Gustavo Werutsky, Miguel H Abreu, Ivana Bozovic-Spasojevic, Irma Den Hoed, Aafke H Honkoop, Maartje Los, Jose P Leone, Nicola S Russell, Tineke J Smilde, Annette W G Van Der Velden, Catherine Van Poznak, Marije M Vleugel, Rachel L Yung, Corneel Coens, Sharon H Giordano, Kathryn J Ruddy

Faculty, Staff and Student Publications

INTRODUCTION: Prospective data about quality of life (QoL) in men with breast cancer (BC) are lacking. A prospective registry (EORTC10085) of men with all BC stages, including a QoL correlative study, was performed as part of the International Male Breast Cancer Program.

METHODS: Questionnaires at BC diagnosis included the EORTC QLQ-C30 and BR23 (BC specific module), adapted for men. High functioning and global health/QoL scores indicate high functioning levels/high QoL; high symptom-focused measures scores indicate high symptoms/problems levels. EORTC reference data for healthy men and women with BC were used for comparisons.

RESULTS: Of 422 men consenting to participate, 363 …

Comparative Genomic Landscape Of Urothelial Carcinoma Of The Bladder Among Patients Of East And South Asian Genomic Ancestry, Taylor Peak, Philippe E Spiess, Roger Li, Petros Grivas, Andrea Necchi, Dean Pavlick, Richard S P Huang, Douglas Lin, Natalie Danziger, Joseph M Jacob, Gennady Bratslavsky, Jeffrey S Ross

Faculty, Staff and Student Publications

BACKGROUND: Despite the low rate of urothelial carcinoma of the bladder (UCB) in patients of South Asian (SAS) and East Asian (EAS) descent, they make up a significant portion of the cases worldwide. Nevertheless, these patients are largely under-represented in clinical trials. We queried whether UCB arising in patients with SAS and EAS ancestry would have unique genomic features compared to the global cohort.

METHODS: Formalin-fixed, paraffin-embedded tissue was obtained for 8728 patients with advanced UCB. DNA was extracted and comprehensive genomic profiling was performed. Ancestry was classified using a proprietary calculation algorithm. Genomic alterations (GAs) were determined using a …

An Update On Strategies To Deliver Protein And Peptide Drugs To The Eye, Sai H S Boddu, Devarshi Acharya, Vivek Hala, Harshil Jani, Sonal Pande, Chirag Patel, Moyad Shahwan, Renukuntla Jwala, Ketan M Ranch

Faculty, Staff and Student Publications

In the past few decades, advancements in protein engineering, biotechnology, and structural biochemistry have resulted in the discovery of various techniques that enhanced the production yield of proteins, targetability, circulating half-life, product purity, and functionality of proteins and peptides. As a result, the utilization of proteins and peptides has increased in the treatment of many conditions, including ocular diseases. Ocular delivery of large molecules poses several challenges due to their high molecular weight, hydrophilicity, unstable nature, and poor permeation through cellular and enzymatic barriers. The use of novel strategies for delivering protein and peptides such as glycoengineering, PEGylation, Fc-fusion, chitosan …

A Portable And Low-Cost Incubator System Enabling Real-Time Cell Imaging Based On A Smartphone, Ari̇f Engi̇n Çeti̇n

Turkish Journal of Physics

Incubators serve as essential tools for maintaining optimal temperature, humidity, and atmospheric gas composition for cell cultures. Their applications span across various fields like cell biology, microbiology, and molecular biology. However, in many cell-based studies, observing cellular changes often necessitates moving cells out of the incubator for microscope examination. Unfortunately, exposing cells to an environment that does not support healthy growth can undermine the reliability of test outcomes. In this article, we present a groundbreaking solution: a cost-effective, portable incubator system seamlessly integrated with a smartphone for real-time characterization tests. This innovation offers comparable imaging capabilities and maintains an environment …

Sex Differences In Recognition Of Face Expressions, Albandri Alotaibi, Abeer Aljuhani, Manal Alqahtani, Nadia Alahmari

Journal of Educational and Psychological Studies

Abstract:Emotional facial expressions are a crucial non-verbal communication skill for humans’ interactions. The current study assessed the impact of sex on emotional face recognition. A total of 125 individuals per-formed an online emotional face recognition task. The stimuli were created recutting male and female Saudi volunteers. Results showed that, except of the male participants having faster responses compared to females in general, no main significant differences between the sex group in accuracy nor any significant interaction between participant sex and the sex of the faces. Our findings suggests that the effect of sex on emotional face recognition needs further investigation …

Carbon Neutrality Implementation Practices And Challenges In The School Environment In The Sultanate Of Oman From The Point Of View Of Principals And Teachers, Abdullah. K. Ambusaidi, Huda M. Al-Dayri

Journal of Educational and Psychological Studies

Abstract: The study aimed to explore the practices of implementing carbon-neutral practices and its challenges in the school environment in the Sultanate of Oman from the viewpoint of principals and teachers. The study adopted the mixed method approach, using two data collection tools to achieve its objectives. The first tool was a questionnaire applied to (412) male and female teachers, besides focus group interviews with a sample consisting of (12) male and female principals and (12) male and female teachers, from cycle II basic education schools in the governorates of Al Batinah South and Al Dakhiliyah. The results showed that …

Message From The President, Georgia Southern University

Messages from the President

No abstract provided.

The Breast Cancer Proteome And Precision Oncology, Jonathan T Lei, Eric J Jaehnig, Hannah Smith, Matthew V Holt, Xi Li, Meenakshi Anurag, Matthew J Ellis, Gordon B Mills, Bing Zhang, Marilyne Labrie

Faculty, Staff and Students Publications

The goal of precision oncology is to translate the molecular features of cancer into predictive and prognostic tests that can be used to individualize treatment leading to improved outcomes and decreased toxicity. Success for this strategy in breast cancer is exemplified by efficacy of trastuzumab in tumors overexpressing ERBB2 and endocrine therapy for tumors that are estrogen receptor positive. However, other effective treatments, including chemotherapy, immune checkpoint inhibitors, and CDK4/6 inhibitors are not associated with strong predictive biomarkers. Proteomics promises another tier of information that, when added to genomic and transcriptomic features (proteogenomics), may create new opportunities to improve both …

Scribbledom: Using Scribble-Annotated Histology Images To Identify Domains In Spatial Transcriptomics Data, Mohammad Nuwaisir Rahman, Abdullah Al Noman, Abir Mohammad Turza, Mohammed Abid Abrar, Md Abul Hassan Samee, M Saifur Rahman

Faculty, Staff and Students Publications

Motivation

Spatial domain identification is a very important problem in the field of spatial transcriptomics. The state-of-the-art solutions to this problem focus on unsupervised methods, as there is lack of data for a supervised learning formulation. The results obtained from these methods highlight significant opportunities for improvement.

Results

In this article, we propose a potential avenue for enhancement through the development of a semi-supervised convolutional neural network based approach. Named “ScribbleDom”, our method leverages human expert’s input as a form of semi-supervision, thereby seamlessly combines the cognitive abilities of human experts with the computational power of machines. ScribbleDom incorporates a …

Spa-Stocsy: An Automated Tool For Identifying Annotated And Non-Annotated Metabolites In High-Throughput Nmr Spectra, Xu Han, Wanli Wang, Li-Hua Ma, Ismael Ai-Ramahi, Juan Botas, Kevin Mackenzie, Genevera I Allen, Damian W Young, Zhandong Liu, Mirjana Maletic-Savatic

Faculty, Staff and Students Publications

MOTIVATION: Nuclear magnetic resonance spectroscopy (NMR) is widely used to analyze metabolites in biological samples, but the analysis requires specific expertise, it is time-consuming, and can be inaccurate. Here, we present a powerful automate tool, SPatial clustering Algorithm-Statistical TOtal Correlation SpectroscopY (SPA-STOCSY), which overcomes challenges faced when analyzing NMR data and identifies metabolites in a sample with high accuracy.

RESULTS: As a data-driven method, SPA-STOCSY estimates all parameters from the input dataset. It first investigates the covariance pattern among datapoints and then calculates the optimal threshold with which to cluster datapoints belonging to the same structural unit, i.e. the metabolite. …

Report Of The Assay Guidance Workshop On 3-Dimensional Tissue Models For Antiviral Drug Development, Robert Jordan, Stephanie L Ford-Scheimer, Rodolfo M Alarcon, Anthony Atala, Jeffrey T Borenstein, Kyle R Brimacombe, Sara Cherry, Hans Clevers, Mindy I Davis, Simon G P Funnell, Lee Gehrke, Linda G Griffith, Abigail C Grossman, Thomas Hartung, Donald E Ingber, Nicole C Kleinstreuer, Calvin J Kuo, Emily M Lee, Christine L Mummery, Thames E Pickett, Sasirekha Ramani, Edwin A Rosado-Olivieri, Evi B Struble, Zhengpeng Wan, Mark S Williams, Matthew D Hall, Marc Ferrer, Sarine Markossian

Faculty, Staff and Students Publications

The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models' utility and limitations, use of existing 3D tissue models for antiviral …

Effectiveness Of Out-Patient Based Acute Heart Failure Care: A Pilot Randomised Controlled Trial, Kyk Wong, D. A. Hughes, M. Debski, N. Latt, O. Assaf, A. Abdelrahman, R. Taylor, V. Allgar, L. Mcneill, S. Howard, Sys Wong, R. Jones, C. J. Cassidy, A. Seed, G. Galasko, A. Clark, D. Wilson, G. K. Davis, A. Montasem, C. C. Lang, P. R. Kalra, R. Campbell, G. Y.H. Lip, J. G.F. Cleland

Peninsula Medical School

Objectives Acute heart failure (AHF) hospitalisation is associated with 10% mortality. Outpatient based management (OPM) of AHF appeared effective in observational studies. We conducted a pilot randomised controlled trial (RCT) comparing OPM with standard inpatient care (IPM). Methods We randomised patients with AHF, considered to need IV diuretic treatment for ≥2 days, to IPM or OPM. We recorded all-cause mortality, and the number of days alive and out-of-hospital (DAOH). Quality of life, mental well-being and Hope scores were assessed. Mean NHS cost savings and 95% central range (CR) were calculated from bootstrap analysis. Follow-up: 60 days. Results Eleven patients were …

Association Between Socioeconomic Factors, Race, And Use Of A Specialty Memory Clinic, Abigail Lewis, Aditi Gupta, Inez Oh, Suzanne E. Schindler, Nupur Ghoshal, Zachary Abrams, Randi Foraker, Barbara Joy Snider, John C. Morris, Joyce Balls-Berry, Mahendra Gupta, Philip R. O. Payne, Albert M. Lai

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: The capacity of specialty memory clinics in the United States is very limited. If lower socioeconomic status or minoritized racial group is associated with reduced use of memory clinics, this could exacerbate health care disparities, especially if more effective treatments of Alzheimer disease become available. We aimed to understand how use of a memory clinic is associated with neighborhood-level measures of socioeconomic factors and the intersectionality of race.

METHODS: We conducted an observational cross-sectional study using electronic health record data to compare the neighborhood advantage of patients seen at the Washington University Memory Diagnostic Center with the …

Effects Of An Ionic Bracelet On Physical, Cognitive, And Integrative Tasks, Eileen Bringman, Chelsea Kimura, Philip Schot

International Journal of Undergraduate Research and Creative Activities

Abstract: One approach in complementary/alternative medicine posits that manipulations of undocumented body energy patterns (biofields) can improve health and function. Various clinician-delivered interventions focus on biofields, but devices that purportedly correct these are also marketed and claim immediate benefits in a variety of domains. OBJECTIVE: To determine acute effects of ionic bracelet use on physical, cognitive and integrative sports-related tasks. METHODS: 52 healthy young adults participated (9 men and 43 women; 20.2±3.4 years of age; 65.4±11.3 kg; 165±6.9 cm). None reported prior or current use of the product. Each completed 2 series of 6 tasks wearing the ionic and an …

An Alternative Strategy For Fabrication Of Robust And Flexible Digital Microfluidic Devices, Nathaniel Thorne, Melissa Lamberto, Audrey Mazza, Sergio Freire

International Journal of Undergraduate Research and Creative Activities

We present a new strategy for the fabrication of digital microfluidic (DMF) devices by research groups without access to well-equipped facilities. Compared to previously developed methods, it increases considerably device yield, and yet simplifies fabrication and enables flexible operation.To this end, we use large (260 and 400 μm) interelectrode gaps to optimize substrate fabrication, breaking the established constraint that gap dimensions must be small (usually < 150 μm) for digital microfluidics. In fact, we show that interelectrode gaps are not limiting features for DMF performance, and may be quite large (> 1 mm). Smooth droplet actuation is ensured by films of perfluoroalkoxy (PFA), which do not require additional coatings; films can be instantly replaced, without the necessity of annealing. Finally, our tests indicate that DMF devices …

The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig, Mir Saleem

Mako: NSU Undergraduate Student Journal

Treatment for osteoarthritis (OA) includes symptom management with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen. However, these drugs pose health risks for long-term use, such as contraindications and gastrointestinal/cardiovascular issues. This systematic review of the literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, in cartilage healing and reducing the progression of OA. It was found that turmeric and ginger can aid in symptom management for OA and promote cartilage regeneration, with turmeric extract yielding greater evidence-based results. Turmeric reduces the amount of pain and stiffness experienced from OA and can restore cartilage by subduing …

Can The Use Of Art And Active Learning Improve Retention And Observational Skill Confidence Among Audiology Graduate Students, Aurora Weaver, Ashlyn Wheat, Travis Riffle, Chelsea Powell, Lindsey Leonard, Ryleigh Prickett, Anna Hill, Larry Molt

Teaching and Learning in Communication Sciences & Disorders

Human anatomy and physiology is considered one of the most difficult courses a student can take in a pre-health professional major in the US (Slominski, et. al., 2017). Research has revealed benefits of the use of art and anatomy within medical education, including improved clinical observational skills, greater understanding of disease and patient perspectives, and greater ability to empathize (Bell & Evans, 2014). Bell and Evans (2014) argue that observational skills are often overlooked in medical education. Use of art assignments in a graduate anatomy and physiology course will be discussed with reference to design and learning outcomes. The purpose …

Tertiary Drug Information Sources For Treatment And Prevention Of Covid-19., Robert D. Beckett, Yashawna Brattain, Judy Truong, Genevieve Engle

Parkview Pharmacy Department

OBJECTIVE: To evaluate tertiary drug information databases in terms of scope, consistency of content, and completeness of COVID-19 drug information.

METHODS: Five electronic drug information databases: Clinical Pharmacology, Lexi-Drugs, AHFS DI (American Hospital Formulary Service Drug Information), eFacts and Comparisons, and Micromedex In-Depth Answers, were evaluated in this cross-sectional evaluation study, with data gathered from October 2021 through February 2022. Two study investigators independently extracted data (parallel extraction) from each resource. Descriptive statistics were primarily used to evaluate scope (i.e., whether the resource addresses use of the medication for treatment or prevention of COVID-19) and completeness of content (i.e., whether …

University Of Northern Iowa Fall Faculty Meeting Program, October 2, 2023, University Of Northern Iowa.

University Faculty Documents

The meeting program from the annual Fall Faculty Meeting of the University of Northern Iowa held on October 2, 2023.

A Multi-Modal Imaging Analysis Of Inter-Community Hub Nodes In Subjective Cognitive Decline Linking Longitudinal Hub Function Disruption To White Matter Integrity Kurtosis, Duncan Nowling

MUSC Theses and Dissertations

Subjective Cognitive Decline (SCD) has garnered much interest as a potential identifiable preclinical stage and indicator of risk for cognitive decline in Alzheimer’s Disease and related dementias (ADRD). Identification of individuals in this stage though is difficult, as they present with objectively normal cognitive evaluation scores, relying instead upon self-report of concern about decline in cognitive abilities. The use of non-invasive in-vivo imaging methods like BOLD functional imaging and diffusion tensor have allowed for complex mapping of both the functional and structural network features unique to this condition. This study furthers this network biomarker map of SCD by investigating the …

Butterfly Classification And Species Discovery Using Genomics, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Genomic sequencing of worldwide butterfly fauna followed by phylogenetic analysis of protein-coding genes informs butterfly classification throughout the taxonomic hierarchy, from families to species. As a rule, we attribute the same taxonomic rank to more prominent clades of comparable divergence (that is, at the same level in the tree). For species delimitation, we use criteria based on relative genetic differentiation and the extent of gene exchange between populations. We analyze the current taxonomic classification of butterflies in the light of genomic phylogenies and encounter clades that correspond to yet unnamed taxa. As a result, 11 tribes, 33 subtribes, 2 genera, …

Information Technology Services Fy2023 - Winona State University, Minnesota, Information Technology Services-Winona State University

Information Technology Services Annual Reports

Information Technology Services (ITS) provides the technology-based foundation to support and empower the Winona State University (WSU) community to meet and exceed their educational and business needs. This is the ITS report for the fiscal year 2023 (July 1, 2022-June 30, 2023).

The Development Of A One-Shot Learning Machine Learning For Industrial Use With Predictive Maintenance, Conor O Brien

Theses

With the advent of Industry 4.0, Manufacturing operations have become more connected and automated. Modern industrial monitoring technology can monitor the performance of both the sensor utilised and the material under monitoring. This has led to a trend where legacy machines without this technology are being removed from production and/or not included in new reconfigurations of production lines, well before their productive lifespan had ended. A key driver for this is the difficulty in retrofitting Predictive Maintenance (PdM) systems to legacy machines, in part due to the machine-to-machine variation present in older machines. Accounting for this variation in PdM systems …

Defending Against External Influences On Educational Data: The Role Of Policies And Procedures, Emily Faulconer, Debra Bourdeau

Publications

Within higher education, there has been increased focus over recent decades on evaluating our teaching practices to provide high-quality evidence of student learning for both internal and external assessment. Even at institutions without a college of education, many faculty are engaged in the scholarship of teaching and learning (SoTL) and/or discipline-based educational research (DBER). While studies are very diverse, and include qualitative and quantitative measures, common data points include student assessment scores and final course grades. In investigations using these measures, researchers acknowledge various mediating and moderating variables, but one particularly impactful variable is often ignored – administrative policies and …

Synthesizing Sentience: Integrating Large Language Models And Autonomous Agents For Emulating Human Cognitive Complexity, Jay Ratican, James Hutson, Daniel Plate

Faculty Scholarship

The paper aims to present a novel methodology for emulating the intricacies of human cognitive complexity by ingeniously integrating large language models with autonomous agents. Grounded in the theoretical framework of the modular mind theory-originally espoused by Fodor and later refined by scholars such as Joanna Bryson—the study seeks to venture into the untapped potential of large language models and autonomous agents in mirroring human cognition. Recent advancements in artificial intelligence, exemplified by the inception of autonomous agents like Age in GPT, auto GPT, and baby AGI, underscore the transformative capacities of these technologies in diverse applications. Moreover, empirical studies …

Deep Learning For Fully Automatic Tumor Segmentation On Serially Acquired Dynamic Contrast-Enhanced Mri Images Of Triple-Negative Breast Cancer, Zhan Xu, David E Rauch, Rania M Mohamed, Sanaz Pashapoor, Zijian Zhou, Bikash Panthi, Jong Bum Son, Ken-Pin Hwang, Benjamin C Musall, Beatriz E Adrada, Rosalind P Candelaria, Jessica W T Leung, Huong T C Le-Petross, Deanna L Lane, Frances Perez, Jason White, Alyson Clayborn, Brandy Reed, Huiqin Chen, Jia Sun, Peng Wei, Alastair Thompson, Anil Korkut, Lei Huo, Kelly K Hunt, Jennifer K Litton, Vicente Valero, Debu Tripathy, Wei Yang, Clinton Yam, Jingfei Ma

Faculty, Staff and Student Publications

Accurate tumor segmentation is required for quantitative image analyses, which are increasingly used for evaluation of tumors. We developed a fully automated and high-performance segmentation model of triple-negative breast cancer using a self-configurable deep learning framework and a large set of dynamic contrast-enhanced MRI images acquired serially over the patients' treatment course. Among all models, the top-performing one that was trained with the images across different time points of a treatment course yielded a Dice similarity coefficient of 93% and a sensitivity of 96% on baseline images. The top-performing model also produced accurate tumor size measurements, which is valuable for …

The Silver Bullet That Wasn’T: Rapid Agronomic Weed Adaptations To Glyphosate In North America, Christopher Landau, Kevin Bradley, Erin Burns, Michael Flessner, Karla Gage, Aaron Hager, Joseph Ikley, Prashant Jha, Amit Jhala, Paul O. Johnson, William Johnson, Sarah Lancaster, Travis Legleiter, Dwight Lingenfelter, Mark Loux, Eric Miller, Jason Norsworthy, Micheal Owen, Scott Nolte, Debalin Sarangi, Peter Sikkema, Christy Sprague, Mark Vangessel, Rodrigo Werle, Bryan Young, Martin M. Williamsii

Department of Agronomy and Horticulture: Faculty Publications

The rapid adoption of glyphosate-resistant crops at the end of the 20th century caused a simplification of weed management that relied heavily on glyphosate for weed control. However, the effectiveness of glyphosate has diminished. A greater understanding of trends related to glyphosate use will shed new light on weed adaptation to a product that transformed global agriculture. Objectives were to (1) quantify the change in weed control efficacy from postemergence (POST) glyphosate use on troublesome weeds in corn and soybean and (2) determine the extent to which glyphosate preceded by a preemergence (PRE) improved the efficacy and consistency of weed …

Sociology Between The Gaps Volume 8 (2023)

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.