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2023

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Wolbachia Infection In Gall Associated Insect Communities In Illinois And Indiana, Jakeb Watts Jan 2023

Wolbachia Infection In Gall Associated Insect Communities In Illinois And Indiana, Jakeb Watts

Masters Theses

Wolbachia is a maternally inherited, gram-negative bacterium and has been found to be associated with up to 60% of all insects, frequently resulting in male-killing, feminization, and cytoplasmic incompatibility in the hosts. Gall wasps and other gall-forming insects induce on various host plants abnormal tissue growths, or plant galls, with distinct morphology. They are considered as obligatory parasites to their host plant. The presence of Wolbachia infection in gall wasp populations in North America has not been extensively documented. Given the strong influence on host reproduction, not knowing Wolbachia infection in insect populations prevents the understanding of how populations are …

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Triclosan Degrading Bacteria From Wastewater Treatment Plants In Central Illinois, Mohammed Alsulami Jan 2023

Triclosan Degrading Bacteria From Wastewater Treatment Plants In Central Illinois, Mohammed Alsulami

Masters Theses

Triclosan is an antimicrobial agent that has been used in personal care products and has been identified to cause malformation on cartilage and bone development in zebrafish and influence on thyroid hormone system in humans. Due to its widespread usage and insufficient removal from wastewater treatment plants, triclosan has emerged as a pervasive contaminant that poses a potential threat to the environment and human health. The goal of the study was to isolate and characterize triclosan-degrading bacteria from WWTPs in central Illinois. Using enrichment culture with NMS media containing triclosan as sole carbon source, eighteen bacterial strains were isolated. The …

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Predictors Of Attitudes About Autism Spectrum Disorder (Asd), Claire Sullivan Jan 2023

Predictors Of Attitudes About Autism Spectrum Disorder (Asd), Claire Sullivan

Masters Theses

Students with Autism Spectrum Disorder (ASD) are far less likely to enroll in secondary education than neurotypical students and students with disabilities (White et al., 2016). There is little research on the factors contributing to the reluctance of young adults on the autism spectrum to seek higher education. This study aims to answer two research questions. The first research question aims to determine if there is a predominance of negative attitudes towards ASD amongst present undergraduate college students. The second research question explores whether this could be a determining factor in a college determination for students with ASD. This current …

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The Influence Of Cover Crops On Grassland Restoration, Josh C. Poland Jan 2023

The Influence Of Cover Crops On Grassland Restoration, Josh C. Poland

Masters Theses

Grassland ecosystems comprise almost a fourth of all Earth’s land mass; however, due to ever-increasing rates of agricultural land conversion, these habitats are facing a large-scale biodiversity crisis. The degradation of grasslands extends beyond physical impacts, such as soil erosion, to include the loss of soil microbial communities as a serious risk to the health and productivity of these habitats. Cover cropping, commonly used in agriculture to revive agricultural soils, has rarely been applied to grassland restorations, and could combat or reverse the harmful effects of modern agriculture techniques. For the first chapter of my thesis, I used a greenhouse …

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A Survey Of Diatom Assemblages Of North Dakota: Identification, Enumeration, And Assessment Of Stream Health With Environmental Variables, Cole Tilford Jan 2023

A Survey Of Diatom Assemblages Of North Dakota: Identification, Enumeration, And Assessment Of Stream Health With Environmental Variables, Cole Tilford

Masters Theses

Diatoms have been used as biological indicators for assessing the environmental health of waterways for over a century. Their low motility and responsiveness to environmental changes makes them ideal for this purpose. North Dakota oil extraction has undergone a massive transformation as hydraulic fracturing across the Bakken Formation and the Williston Basin has increased over the last 20 years. Hydraulic fracturing increased the potential for environmental pollution of North Dakota’s waterways, especially in the form of highly saline hydraulic fracturing liquid. Many North Dakota streams are already saline and additional salinity could cause drastic changes in aquatic ecosystems. North Dakota …

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Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott Jan 2023

Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott

Graduate Theses, Dissertations, and Problem Reports (ETD)

For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …

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A Case Study Of Makerere University In Uganda Through The Lens Of U.S. Land-Grant Higher Education, Christina L. Hand Jan 2023

A Case Study Of Makerere University In Uganda Through The Lens Of U.S. Land-Grant Higher Education, Christina L. Hand

Graduate Theses, Dissertations, and Problem Reports (ETD)

This case study examines Makerere University through the lens of U.S. land-grant ideal and normative domains in order to provide a deeper understanding of global higher education. A case study uses multiple types of data to create a holistic perspective. As well as interviewing Makerere stakeholders representing diverse sectors, numerous documents and different types of media were analyzed enabling a triangulation of data. Six major themes emerged focusing on Makerere’s aspiration to be a research-led institution, the impact of neoliberalism, challenges in undergraduate education, the importance of reputation and saga, the ever-present role of the Ugandan government, and the continuing …

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Exploring Early Childhood Educators’ Attitudes About Addiction And Their Association With Student-Teacher Relationships, Megan E. Mikesell Jan 2023

Exploring Early Childhood Educators’ Attitudes About Addiction And Their Association With Student-Teacher Relationships, Megan E. Mikesell

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project aimed to address significant gaps in literature around addiction-related attitudes by identifying early childhood educators’ addiction-related attitudes and how these attitudes associate with their relationships with students who come from homes with addiction. A sample of 501 ECEs completed an online survey which included the Public Attitudes About Addiction Survey (PAAS; a 54-item measure used to identify a person’s beliefs about addiction across five models), the Student-Teacher Relationship Scale (STRS; a 15-item scale used to measure the level of closeness and conflict), and various demographic and community questions. Path analysis revealed that both moral and nature aligned attitudes …

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Computational Studies On Molecular Mechanisms For Dysregulation Of Monoamine Transporters By Hiv-1 Tat And Drug Discovery Of Novel Phosphodiesterase-2 Inhibitors, Charles A. Adeniran Jan 2023

Computational Studies On Molecular Mechanisms For Dysregulation Of Monoamine Transporters By Hiv-1 Tat And Drug Discovery Of Novel Phosphodiesterase-2 Inhibitors, Charles A. Adeniran

Theses and Dissertations--Chemistry

Computational chemistry methods have been greatly used and has great potential in drug discovery and understanding the detailed molecular mechanism of biological processes. Scientific questions can initially be addressed using computational modeling and simulation studies. The common feature in this work is to understand intermolecular interactions related to protein targets in the brain, as it relates to HIV infection and Alzheimer’s Disease. HIV is among the world’s most deadly infectious diseases. Recent therapeutic advancements have begun to increase the life expectancy of people living with this virus. The mechanisms that lead to neurobiological complications known as HIV- associated neurocognitive disorders …

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Detection And Observed Correlations Of Statin And Beta-Blocking Pharmaceuticals In West Virginia Surface Waters And Ichthyofauna, Joseph W. Kingsbury Jan 2023

Detection And Observed Correlations Of Statin And Beta-Blocking Pharmaceuticals In West Virginia Surface Waters And Ichthyofauna, Joseph W. Kingsbury

Graduate Theses, Dissertations, and Problem Reports (ETD)

Within this thesis the source, presence, and the estimated ecotoxicological effects of cardiovascular medicines, specifically statins and beta-blockers are described within the Buckhannon, Tygart Valley, and West Fork Rivers of West Virginia. Included within this thesis is a general introduction providing key background information and relevant research related to the source, presence, and known toxicity of statins and beta-blockers. Following the general introduction there are 3 distinct chapters. Chapter 1 focuses on the estimated demographic based source loadings and the surface water concentration characteristics of statins and beta-blockers within the three rivers. Chapter 2 investigates the effects of statins and …

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Leveraging Artificial Intelligence And Geomechanical Data For Accurate Shear Stress Prediction In Co2 Sequestration Within Saline Aquifers (Smart Proxy Modeling), Munirah Alawadh Jan 2023

Leveraging Artificial Intelligence And Geomechanical Data For Accurate Shear Stress Prediction In Co2 Sequestration Within Saline Aquifers (Smart Proxy Modeling), Munirah Alawadh

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research builds upon the success of a previous project that used a Smart Proxy Model (SPM) to predict pressure and saturation in Carbon Capture and Storage (CCS) operations into saline aquifers. The Smart Proxy Model is a data-driven machine learning model that can replicate the output of a sophisticated numerical simulation model for each time step in a short amount of time, using Artificial Intelligence (AI) and large volumes of subsurface data. This study aims to develop the Smart Proxy Model further by incorporating geomechanical datadriven techniques to predict shear stress by using a neural network, specifically through supervised …

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Evaluating The Contribution Of Adjacent Charges On The Observed Ph-Dependent Binding Profile For A Vhh/Antigen Interaction With A Linked Histidine Protonation Equilibria, Kiruthika Arulmoly Jan 2023

Evaluating The Contribution Of Adjacent Charges On The Observed Ph-Dependent Binding Profile For A Vhh/Antigen Interaction With A Linked Histidine Protonation Equilibria, Kiruthika Arulmoly

Graduate Research Theses & Dissertations

pH dependent protein-protein interactions are of great importance for various biological processes. In addition, the generation of engineered pH-dependent therapeutic antibodies opens opportunities for the extension of therapeutic half-life, thereby reducing drug dosage or frequency of administration, as well as providing pH-dependent targeting, such as the tumor microenvironment. Engineering pH-dependent antibody-antigen interaction is mostly achieved through the incorporation of ionizable residues within the antigen binding interface. These ionizable residues must undergo a change in environment upon forming a protein-protein complex, which causes a change in the ionizable group’s pKa value. This coupled protonation equilibria is responsible for the observed pH-dependent …

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Bioanalytical Studies Of Disease Protein Profiles: Maldi-Tof Ms, Prajkta Satish Chivte Jan 2023

Bioanalytical Studies Of Disease Protein Profiles: Maldi-Tof Ms, Prajkta Satish Chivte

Graduate Research Theses & Dissertations

Coronavirus disease-2019 (COVID-19), which is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has ravaged the world for the past 3 years. Even today, there still exists a need for rapid, accurate, economical and non-invasive diagnostic testing platforms that yield high specificity and sensitivity towards the constantly mutating SARS-CoV-2. Research has consistently indicated saliva to be a more amenable specimen type for early detection of SARS-CoV-2, compared to the oral and nasopharyngeal swabs. Considering the limitations and high demand of the existing COVID-19 testing platforms, this dissertation work studies used MALDI-ToF MS (matrix-assisted laser desorption/ionization-time of …

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Structural Analysis Of Polar Aggregates And Inter-Ionic Distances In Room Temperature Ionic Liquids, Emily Elizabeth Dalbey Jan 2023

Structural Analysis Of Polar Aggregates And Inter-Ionic Distances In Room Temperature Ionic Liquids, Emily Elizabeth Dalbey

Graduate Research Theses & Dissertations

Ionic liquids have a wide variety of applications in chemistry due to their unique properties such as low flammability, low volatility, and high thermal and chemical stability. These properties make them great solvents, electrolytes for lithium-ion batteries, and more. Ionic liquids are salts whose components are mis-matched in size and shape leading to low melting points. To design an ionic liquid with a desired property it is key to first understand their structure. Lineshape analysis of the charge alternation peak from the experimentally measured or computationally calculated X-ray scattering data can give information about the size of the polar aggregates …

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Evaluating The Attention Training Technique As A Transdiagnostic Intervention For Fear-Based Psychopathological Symptoms: A Randomized Controlled Trial, Benjamin John Ellem Jan 2023

Evaluating The Attention Training Technique As A Transdiagnostic Intervention For Fear-Based Psychopathological Symptoms: A Randomized Controlled Trial, Benjamin John Ellem

Graduate Research Theses & Dissertations

Recent research indicates that fear-related psychological disorders are a distinguished class of psychopathology, all of which share the underlying endophenotype of maladaptive acute fear responding. The relationship between maladaptive fear responding and psychopathology has been found to be moderated by executive functioning capacity—most notably attentional control. However, the current psychopathological nosology does not link fear-based disorders together. As a result, many fear-based disorders are treated separately with different evidence-based psychotherapies. These psychotherapies tend to focus on reducing phenotypic behaviors or self-reported experience of symptoms. Individuals with fear-based disorders may be better served by treatments that focus on the aforementioned endophenotypes …

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Three Essays On The Effects Of Parental Income And Labor Supply On Child Health And Labor Market Outcomes., Kassahun Mamo Geleta Jan 2023

Three Essays On The Effects Of Parental Income And Labor Supply On Child Health And Labor Market Outcomes., Kassahun Mamo Geleta

Graduate Research Theses & Dissertations

This dissertation constitutes three separate essays on labor and health economics using the Panel Study of Income Dynamics (PSID) dataset. The first essay examines the long-run effect of childhood poverty on labor market outcomes using propensity score matching (PSM) and average causal mediation effect (ACME) methods. The results show that persistent childhood poverty significantly decreases average annual labor income and hours worked, whereas it increases the number of weeks unemployed per annum during adulthood. The study also shows that a significant portion of the total effect of childhood poverty on labor market outcomes passes indirectly through its negative effect on …

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The Relationship Between Fully Online Gateway Science Courses And Student Academic Performance In Health Career Associate Degree Programs At Regional Community College, Mukesh George Jan 2023

The Relationship Between Fully Online Gateway Science Courses And Student Academic Performance In Health Career Associate Degree Programs At Regional Community College, Mukesh George

Graduate Research Theses & Dissertations

The severe shortage of healthcare professionals creates an increased demand for new graduates in Allied health and Nursing programs. Gateway science courses to HCAD programs such as A&P are often considered predictors of student success in Allied health and Nursing programs. A&P courses have been traditionally taught face-to-face, and the COVID pandemic has forced institutions to switch these courses to a fully online format. Despite its increased popularity, the impact of fully online gateway courses on student academic performance in HCAD programs needed to be clarified. This quantitative study examined the relationship between fully online gateway science courses and student …

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Visualizing Dynamic Multivariate Networks, Bharat Kumar Kale Jan 2023

Visualizing Dynamic Multivariate Networks, Bharat Kumar Kale

Graduate Research Theses & Dissertations

Many real-world networks are multivariate in nature and also evolve over time. Such a network whose nodes and/or edges along with their associated attributes, evolve over time is called A dynamic multivariate network (DMVN). For instance, in the scholarly community, researchers often collaborate with others. These collaborations have various attributes, such as scientific domain and number of publications, as well as they change over time. At any given point in time, the collaborations among researchers can be modeled as a network resulting in a collaboration network. When the changes in collaborations and associated attributes are also included in the network, …

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I. Design, Synthesis, And Evaluation Of The Human Phoshodiesterase-4 And Fungal Acetyl Coa Synthetase Enzyme Inhibitors Ii. Evaluation Of Biological Activity Of Kenyan Medicinal Plants, Chaitanya Kondam Jan 2023

I. Design, Synthesis, And Evaluation Of The Human Phoshodiesterase-4 And Fungal Acetyl Coa Synthetase Enzyme Inhibitors Ii. Evaluation Of Biological Activity Of Kenyan Medicinal Plants, Chaitanya Kondam

Graduate Research Theses & Dissertations

Phosphodiesterase-4 (PDE4) enzyme mainly present in immune cells, epithelial cells, and brain cells that regulate inflammation and epithelial integrity in cells. Inhibition of PDE4 enzyme leads to regulation of various inflammatory mechanisms by elevation of cyclic adenosine monophosposphate (cAMP) levels in the cells. PDE4 enzyme is promising target for treatment of pulmonary, dermatological, and neurological inflammatory diseases. Several PDE4 inhibitor drugs Roflumilast, Apremilast, and Crisaborole were approved and marketed as Dalsirep, Otezla and Eucrisa for the treatment of inflammatory pulmonary diseases, psoriatic arthritis, and atopic dermatitis. However, these drugs have adverse effects such as nausea, emesis, and gastrointestinal effects. Benzothiazole …

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Intergenerational Transmission Of Parenting: Does Emotion Regulation Buffer The Effect Of Negative Early Care Experiences On The Cortisol Stress Response And Subsequent Caregiving?, Erin Rochelle Mckay Jan 2023

Intergenerational Transmission Of Parenting: Does Emotion Regulation Buffer The Effect Of Negative Early Care Experiences On The Cortisol Stress Response And Subsequent Caregiving?, Erin Rochelle Mckay

Graduate Research Theses & Dissertations

A phenomenon known as the intergenerational transmission of parenting, where children tend to parent their children in a manner similar to how their own parents provided care, has received notable attention within developmental research. While several mechanisms focusing on cognitive and psychological factors have been proposed, there is less research examining biological mechanisms within the intergenerational transmission of parenting framework, especially when considering caregiving behavior exhibited in the context of child distress. Further, few studies have examined parent attributes which may disrupt the intergenerational transmission of parenting. The current study seeks to examine the hypothalamic-pituitary-adrenal (HPA) axis stress response as …

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Alignment And Range Verification In Proton Therapy Using Proton Radiography And Proton Ct, Joseph Piet Jan 2023

Alignment And Range Verification In Proton Therapy Using Proton Radiography And Proton Ct, Joseph Piet

Graduate Research Theses & Dissertations

Protons are used in radiation therapy to lower doses to healthy tissues by utilizing their Bragg peak. Protons can be used both in imaging and treatment. One of the uses of protons in imaging we tested is its use to align patients using a single beam's eye proton radiograph (pRad). By using a beam's eye pRad, and comparing the water equivalent thickness (WET) to proton digitally reconstructed radiographs (pDRRs), we show that we can measure the best alignment on six axes, three translational and three rotational. This is done by defining a cost function, chi squared, which quantifies the misalignment …

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"It Solidified My Position That I Should Be In Science": A Case Study On How Participating In A Stem Intervention Program Influences The Science Identity Development Of Low-Income Students In Stem At A Community College., Manuel Rodriguez Jan 2023

"It Solidified My Position That I Should Be In Science": A Case Study On How Participating In A Stem Intervention Program Influences The Science Identity Development Of Low-Income Students In Stem At A Community College., Manuel Rodriguez

Graduate Research Theses & Dissertations

Individuals coming from low-income backgrounds, particularly women and people of color, are disproportionately underrepresented in STEM fields. The low representation is often attributed to low enrollment and completion rates in STEM programs. Community colleges play a crucial role in increasing diversity in the workforce. However, there is not much information about how community college students’ experiences in STEM academic programs supports their science identity development. The purpose of this case study was to understand how participation in a STEM intervention program assisted low-income students in their science identity development. Science identity development has been used to understand how students’ interactions …

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Felon Disenfranchisement: An Attack On Democracy In The United States, Katie Rodrigues Jan 2023

Felon Disenfranchisement: An Attack On Democracy In The United States, Katie Rodrigues

Student Publications and Presentations

No abstract provided.

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Covid-19 Stress And Parenting Practices: Maternal Stress And Emotion Regulation Strategies, Jordan R. Kaye Jan 2023

Covid-19 Stress And Parenting Practices: Maternal Stress And Emotion Regulation Strategies, Jordan R. Kaye

Graduate Research Theses & Dissertations

The outbreak of the novel (COVID-19) pandemic in March 2020 resulted in changes within society that had lasting repercussions. Specifically for families, the sudden changes were observed to be stressful in conjunction with the added stress of simultaneously caring for children. The current literature has demonstrated that stress related to COVID-19 (i.e., pandemic-related stress) has been associated with both elevated maternal parenting stress and unfavorable parenting behaviors. Given these findings, the current study examined the influence of pandemic-related stress on parenting stress and subsequent parenting behaviors. Further, the current study considered maternal emotion regulation attributes – specifically cognitive reappraisal and …

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Design And Synthesis Of Acetyl Coa Synthetase-1 Inhibitors, Theodore Cormac Jones Jan 2023

Design And Synthesis Of Acetyl Coa Synthetase-1 Inhibitors, Theodore Cormac Jones

Graduate Research Theses & Dissertations

Pathogenic fungi pose a severe threat to patients in developing countries. Although these fungi claim the lives of millions every year, modern healthcare is sorely lacking in ways to control them. This work will explore the development and synthesis of four series of compounds with potential antifungal activity via inhibition of ACS1. The first is based on a thienopyrimidine moiety and was discovered in a screen of compounds from the Hagen Group’s in-house compound library. Analogs in this series demonstrated some degree of improvement in activity over the lead compound, but they were held back by solubility issues and poor …

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Measuring The Impact Of Youth Research In The Us Policy Documents, Miftahul Jannat Mokarrama Jan 2023

Measuring The Impact Of Youth Research In The Us Policy Documents, Miftahul Jannat Mokarrama

Graduate Research Theses & Dissertations

With the growing demand for aligning research with society, in recent years, researchers and policymakers have been unequivocal in increasing research use in the policy-making process. Integrating research into policy formulation not only results in more effective policies but also allows researchers to extend the reach and influence of their work to a broaderand more diverse audience. In the US, as youth comprise a substantial portion of the population, their perspectives, needs, and aspirations must be understood and addressed in policymaking. Therefore, in this thesis, we assessed the impact of youth-focused research on US policy documents using state-of-the-art pre-trained Large …

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A State Space Modeling Approach To Eeg Artifact Removal, Patrick B. Rafael Jan 2023

A State Space Modeling Approach To Eeg Artifact Removal, Patrick B. Rafael

Graduate Research Theses & Dissertations

In this work, a state space modeling approach is applied to an Electroencephalography(EEG) recording for the purpose of artifact removal, and is compared against Independent Components Analysis (ICA), the current gold standard. Issues of model identifiability are touched on, and Hamiltonian Monte Carlo (HMC) is used to estimate a linear non-Gaussian state space model. Results show that estimating such a model is a nontrivial matter, and the full utility of the state space approach remains to be demonstrated.

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Exploring Disparities In Prenatal Smoking And The Role Of Adverse Childhood Experiences, Patricia Da Rosa Jan 2023

Exploring Disparities In Prenatal Smoking And The Role Of Adverse Childhood Experiences, Patricia Da Rosa

Electronic Theses and Dissertations

Cigarette smoking is the most common cause of premature death, killing half of its users. During pregnancy, smoking continues to be the leading cause of premature death for both mothers and newborns. Research has consistently demonstrated smoking is not randomly distributed across populations; it is, instead, socially patterned. Women from lower socioeconomic backgrounds, those experiencing mental health issues, and rural area residents are disproportionately affected. The life course framework emphasizes the impact of exposures in early life on shaping health inequities. Eliminating health inequities, including risky behaviors such as smoking, requires an understanding of the pathways that generate these inequities. …

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Interventions For The Mind, Body, And Spirit Of Ncaa Student-Athletes: An Evidence To Practice Review, Molly M. Osborn, Victoria A. Williams, Allison B. Smith, Zachary K. Winkelmann Jan 2023

Interventions For The Mind, Body, And Spirit Of Ncaa Student-Athletes: An Evidence To Practice Review, Molly M. Osborn, Victoria A. Williams, Allison B. Smith, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Life as an athlete in the National Collegiate Athletic Association (NCAA) can enrich and play an integral part in a young student-athlete's development. Consequently, this lifestyle comes with its own stressors that affect one’s physical, spiritual, and psychosocial well-being. These issues can affect various aspects of a student-athlete’s life, including their performance in sports, school, and social settings. Recent studies have begun connecting these domains directly to the health and well-being of NCAA student-athletes, leading to new evidence focused on the best intervention protocols for the biopsychosocial-spiritual (BPSS) model of health. A systematic review was conducted using five electronic databases. …

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Editorial: Microglia In Neuroinflammation, Pinar Ayata, Ido Amit, Carla M. Cuda Jan 2023

Editorial: Microglia In Neuroinflammation, Pinar Ayata, Ido Amit, Carla M. Cuda

Advanced Science Research Center

Microglia are a resident innate immune cell population of the central nervous system (CNS) derived from yolk sac erythro-myeloid progenitors that migrate to the developing brain prior to the formation of the blood-brain barrier. This critical cell population has gained considerable traction in the literature as it is considered a protective barrier from CNS damage and, yet, can also serve as a primary mediator of neuroinflammation. Under normal physiological conditions, microglia perform homeostatic functions, such as parenchymal surveillance, neurotrophic support, pathogen or debris removal, and maintenance of synaptic homeostasis and neuronal plasticity.

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