Digital Commons Network^™

Kpt-330 Synergizes With Everolimus To Reduce Mtorc1-Overactive Basal-Like Triple-Negative Breast Cancer Brain Metastasis Burden, Aaron D. Valentine

Theses and Dissertations

Triple-negative breast cancer (TNBC), a highly metastatic breast cancer subtype, accounts for approximately 20% of all breast cancer diagnoses. Basal-like TNBC is notably difficult to treat due to the lack of actionable drug targets such as estrogen and progesterone receptors, as well as HER2. Due to the deficiency in TNBC-targeting drugs that are able to cross the blood-brain barrier (BBB) for breast-to-brain metastasis, there is a need to develop novel BBB-permeable treatments. After preliminary testing, KPT-330 (XPO1 inhibitor) and everolimus (FKBP1A/mTOR inhibitor) were selected as drug candidates for this study. Patient-derived xenograft (PDX) models for in vitro and in vivo …

Impact Of Portal Of Exit On The Prevalence Of Apical Periodontitis In Root Canal Treated Maxillary Molars With Missed Second Mesiobuccal Canals: A Cbct Study, Jing Ye

Theses and Dissertations

Objective: To evaluate the association of portal of exit (POE) of the second mesiobuccal (MB2) canal with the prevalence of apical periodontitis (AP) in previously treated maxillary molars

Methods: Cone beam computed tomography (CBCT) scans of 106 previously treated maxillary molars seen for either recall or retreatment in the past 3 years were included in the study. Scans were reviewed by one endodontic resident and one board-certified endodontist to determine the POE (separate versus common) of the missed MB2 canal and the presence or absence of a periapical hypo-dense area. Association between AP and portal of exit was assessed using …

Examining Allostatic Load As A Biological Mechanism Linking Childhood Adversity And Pediatric Pain, Angela Pascale

Theses and Dissertations

Despite a strong literature base relating childhood adversity to pain, the biological mechanisms underlying these associations remain unclear. Theoretical and preliminary empirical evidence supports allostatic load as a potential biological mechanism, though prior studies investigating associations between childhood adversity and elevated allostatic load and/or between elevated allostatic load and poorer pain outcomes have primarily focused on adult populations and individual allostatic load indicators rather than a comprehensive index. Thus, the current study built upon prior literature by testing longitudinal relationships between childhood adversity and multiple biological indicators spanning across physiological systems (i.e., comprehensive allostatic load index) and pediatric pain outcomes …

How Do Cultural Norms Shape Healthy Eating In African Americans? The Role Of Cultural Congruence And Mindsets Of Health In Healthy Eating Intentions Among African American College Students, Danyel Smith

Theses and Dissertations

Targeting dietary behaviors is a predominant strategy to reduce rates of obesity among African Americans, across the lifespan. Notably, dietary behaviors are shaped by social, cultural and environmental affordances. This study integrated Theory of planned behavior (TPB), identity-based motivation, and mindset theory to unearth cultural mechanisms that inform motivations to eat healthy among African American college students. This project employed a cross-sectional (Study 1) and experimental design (Study 2) to contextualize the antecedents of intentions to eat healthy among African American college students. Recruitment occurred via university-wide digital channels. Eligible participants: were 18+ years; Black/African American; were undergraduate students; and …

Vulnerability And Adaptation Of Neocortical Neuron Subtypes In Models Of Concussive Traumatic Brain Injury And Multiple Sclerosis, Alan C. Harris Jr.

Theses and Dissertations

The pathognomonic sequela of traumatic brain injury is traumatic axonal injury, the

burden of which correlates with less favorable outcomes. Elucidation of

the intrinsic variables that endow delineated neuronal subgroups and microanatomical domains with outsized vulnerability to injury represents a critical domain of inquiry toward the successful translation of disease-modifying therapeutics. To this end, we studied mild traumatic brain injury (mTBI) within the central fluid percussion model to examine the consequences of mTBI on the morphology and functional integrity of the axon initial segment (AIS) and the relative contributions to network homeostasis mediated by distinct populations of inhibitory interneurons. One …

The Relationship Between Gluteus Maximus Activation And Running Economy In Recreational Distance Runners, Carlos Hernandez

Cal Poly Humboldt theses and projects

Within the running community, there are strategies that a trainer will utilize to improve the performance of an athlete. One of these strategies suggests that an increase in activation of the Gluteus Maximus (GM) muscle will result in an increase in the efficiency of runners. The primary purpose of this study is to examine the relationship between GM activation and running economy (RE).

Methods: Three female and seven male recreational runners (27±8 yrs) from California Polytechnic State University, Humboldt and the local community. A Pearson product-correlation was used to determine the strength of the relationship between Gluteus Maximus activation and …

Macrolichen Inventory Of The Horse Mountain Botanical Area, Six Rivers National Forest, California, Usa, Sarah Norvell Conway

Cal Poly Humboldt theses and projects

Macrolichen diversity and community composition was determined for an area of high botanical interest in the Coast Ranges of Northern California – the Horse Mountain Botanical Area (HMBA) in Six Rivers National Forest. The Coast Ranges have been suggested to have high epiphytic macrolichen diversity, yet detailed site-specific macrolichen surveys are lacking for the area. Here we present comprehensive data on macrolichens of the HMBA integrated with environmental metadata at the landscape level. Twenty 0.4 ha sampling plots were positioned across the varying habitats of the HMBA and macrolichens were intensively sampled from all substrata. Out of 888 total collections, …

Synthesis And Spectral Identification Of New Azo-Schiff Base Ligand Derivative From Aminobenzylamine And Its Novel Metal Complexes With Cu(Ii), Zn(Ii) And Hg(Ii), Athmar Ali Kadhim, Ibtihal Kadhim Kareem, Kawther H.Mhdi, Ban Abdullah Hindi

Hilla University College Journal For Medical Science

The research included the preparation of the New Azo Schiff Ligand derived from 4,5-diphenyl imidazole. The ligand was prepared from the amine reactor with the coupling component in order to prepare the azo amino benzayl amine. After that the last compound and 4-hydroxy benzaldehyde which obtained the ligand mentioned some metallic complexes were prepared for the ions of Cu(II), Zn(II) and Hg(II).The New azo- Schiff ligand complexes after purification were identification by using the available spectral and analytical methods such as Mass spectrum for the New ligand and (ultraviolet-visible ,FTIR) spectroscopy, CHN analytics', Atomic absorption, and conductivity measurement.

According to …

Impact Of A Low-Stakes Assessments Model With Retake In General Chemistry: Connecting To Student Attitudes And Self-Concept, Vijay Vyas, Llanie Nobile, James R. Gardinier, Scott A. Reid

Chemistry Faculty Research and Publications

Across a variety of fields, the use of low-stakes assessments has led to reductions in achievement gaps and improved student success. Here, we probe the use of a low-stakes assessment model with a retake option for failed quizzes in a two-semester general chemistry sequence. We find that the quiz-retake rate in general chemistry II was significantly higher for students who had completed a retake in a general chemistry I section, and the percentage of students who failed at least one quiz in general chemistry I but passed all quizzes in general chemistry II was significantly higher for students who had …

Surface Modification Of Carbon-Based Electrodes For Electrochemical Conversion Processes: Oxygen Reduction Reaction And Bicarbonate Conversion, Udari Shyamika Kodithuwakku Arachchige

Theses and Dissertations--Chemistry

Oxygen reduction reaction (ORR) and conversion of bicarbonate into value-added chemicals are two significant electrochemical processes for energy storage and conversion. ORR is an important electrochemical reaction in fuel cells and metal-air batteries that provide power conversion and storage capacity, respectively, for portable electronics, and electric vehicles. However, the performance of catalysts (e.g., platinum-based) is critically limited by slow kinetics, inefficient four-electron pathway, and surface deactivation. This limited performance of platinum-based catalysts, the scarcity of platinum, and vulnerable supply chains for critical minerals require the development of alternative electrocatalysts now more than ever. Carbon-based materials possess several key properties that …

Investigating Ru(Ii) Anticancer Agents With Non-Canonical Mechanisms Of Action, Richard Joseph Mitchell

Theses and Dissertations--Chemistry

Platinum(Pt)-based agents are used in approximately 50% of all cancers that are treated with chemotherapy. Unfortunately, the dose-limiting toxicity of these agents remains problematic for patients undergoing treatment. Additionally, Pt(II) therapeutics suffer from transporter-dependent uptake, limited chemical functionalization, and high susceptibility to inactivation by free thiols within the cytosol. Developing small molecules with non-canonical mechanisms of action is one strategy that can be employed to circumvent these limitations. Utilization of coordination complexes with ruthenium(Ru) metal centers is one attractive strategy. Ru(II) compounds are often octahedral, facilitating greater accessibility for chemical diversity; Ru(II) complexes use passive transport and transferrin-mediated transport for …

Application Of Mass Spectrometry For The Characterization Of Synthetic Oligomers And Natural Lignin, Poorya Kamali

Theses and Dissertations--Chemistry

As part of the ongoing effort to substitute finite fuel and chemical resources with renewable ones, biomass is emerging as one of the most promising sources. Biomass consists of three main components of cellulose, hemicellulose, and lignin. Traditionally, cellulose has been used extensively in pulping industry, while lignin has been considered waste and is burned to generate heat. Lignin, a complex aromatic polymer component of biomass, has the potential to be used as a source of aromatic chemicals and pharmaceutical synthons. The recalcitrant nature of lignin, the lack of effective lignin breakdown methods and analytical techniques to analyze it are …

Women's Empowerment Through Strength Sports—And Its Limits, Alison Clark Efford

History Faculty Research and Publications

This historical case study demonstrates that the purpose of a program of strength training affects whether it will empower women. The Turnverein or Turners was a German American organization that combined physical training, ethnic pride, and civic engagement. From the 1880s to the 1920s, it was at the forefront of promoting women’s exercise in the United States, including strength training with weighted clubs, dumbbells, and apparatuses. Woman Turners seized on physical training to challenge patriarchal power structures. They found joy in exertion, achievement, and comradery, while contesting the notion that to be feminine meant to be weak. Yet male Turners …

Herstory 101: Examining The Representation Gap Of Bipoc Women Educational Leaders, Kinasha Brown

Graduate Research Theses & Dissertations

Background/Purpose: The purpose of this study was to examine how lived experiences influenced perceptions of leadership self-efficacy amongst Black, Indigenous, or Person of Color (BIPOC) women educational leaders in order to minimize future representation gaps in educational leadership. Methods: Qualitative interviews were conducted with 14 BIPOC cis-gender female leaders who worked in a large school district in the southwestern region of the United States. Results: Examining the social constructs of race, gender, leadership makes clear how BIPOC women are socially constructed as inferior and how that played out in this educational leadership settings. The interconnectedness of both approaches contributes to …

Using Machine Learning To Predict Student Outcomes, Saba Fatima

Graduate Research Theses & Dissertations

Predicting students’ performance to identify which students are at risk of receiving aD/Fail/Withdraw (DFW) grade and ensuring their timely graduation is not just desirable but also necessary in most educational entities. In the US, not only is the Science, Technology, Engineering, and Mathematics (STEM) major becoming less popular among students, the graduation rate of STEM students is steadily declining. The lack of STEM graduates in the US is a serious problem that will place this country at a disadvantage as a competitor in international technological advancement. In order to secure its status as a technological leader internationally, the US institutions …

A Single-Case Alternating Treatments Design Utilzing Quantitative Electroencephalography To Observe And Measure Mental State Trends During Individual Participant Non-Nature-Based Small Initiative Adventure Therapy Experiences, Patrick Lane Robert Mcmillion

Graduate Research Theses & Dissertations

This single-case alternating-treatments design research study observed and measured mental state trends during the counseling approach known as Adventure Therapy (AT) using quantitative electroencephalography (qEEG). Participants wore a qEEG headset while participating in a multi-stage AT experience. Two problems were addressed in this study. The first was the lack of research in AT utilizing other empirical measures beyond subjective report surveys and the outcomes of specific programs. The second was the lack of neuroscientific measurement of counseling approaches and interventions within the field of counseling in general. There is a need for empirical evidence supporting AT to address access barriers …

Surface Modified Titanium And Doxycycline Loaded Pcl/Plga Nanofibers For Improved Cellular Interaction And Biocompatability, Dexter D. Kling

Graduate Research Theses & Dissertations

Biomaterials play an important role in modern medicine through their complexfunctionalities, as implants, grafts, and drug delivery systems. The addition of dopants and biomolecules in biomaterials offers unique solutions to common issues and provides new methods of improving overall health. In our work, we examined osteoblast cell interactions with titanium (Ti) after alkali treatment and deposition of magnesium (Mg) and iron (Fe). We also studied the antibacterial properties of doxycycline loaded polymeric nanofibers produced via electrospinning. To study the biological properties of surface-modified Ti, we first prepared commercially pure titanium samples by grinding and polishing, then performed alkali treatment in …

Synthetic Methodologies Using Nucleophile-Electrophile Chemistry, Jacob C. Hood

Graduate Research Theses & Dissertations

Synthetic organic chemistry is a vital part of the modern world – making up 15-20% of the U.S. economy. New synthetic reactions can lower manufacturing costs and create more environmentally friendly processes. Substitution, addition, and superelectrophilic chemistry are potent tools to afford potentially essential compounds. The work outlined in this dissertation recounts the expansion of synthetic methodologies employing substrates with a wide range of electrophilicities toward synthesizing heterocyclic molecules. These concepts are summarized in chapter 1. Chapter 2: N-Heterocyclic alcohols are excellent substrates for superacid-promoted Friedel-Crafts reactions. The N-heterocyclic alcohol ionizes to produce reactive, dicationic intermediates, providing good to excellent …

Engineering Ph-Dependent Antibody Interactions Through Introduction Of Linked Protonation Equibria Within The Antigen Binding Interface Or Linked Oligomeric Interfaces, Tosha Laughlin

Graduate Research Theses & Dissertations

Antibodies are widely applied as affinity reagents across a variety of fields, due to their high affinity and specificity. While high affinity across a range of conditions is useful for many applications, the ability to modulate affinity with environmental conditions (e.g., pH) opens new opportunities for antibody applications. This dissertation focuses on exploring the impact of an antibody’s interface size on engineered pH dependence, as well as exploring engineered pH-dependence through perturbing oligomerization equilibria that are linked to target binding. An anti-maltose binding protein (MBP) Fab 7O antibody fragment was used as a large protein-protein interface model to explore a …

A Survey Research Study Of Conference Attendance And Change: What Do Educators Gain From Anti-Bias/Anti-Racist Professional Development?, Erin Rae

Graduate Research Theses & Dissertations

Research studies suggest that professional development would betterprepare the 84% White teaching force to serve diverse classrooms. Schools have begun providing professional development with desired outcomes of better serving their diverse student body. This research study focused on educators who received summer camp-style immersive anti-bias/anti-racist professional development and examined the relationships between aspects of educator change as measured by a survey instrument (n=57). The research found that teachers were likely to make anti-bias/anti-racist classroom practice changes after attending the social justice summer camp. By better understanding educator change proceeding summer camp style conferences, this study offers implications for implementing anti-bias/anti-racist …

Interactions Of Sexuality Training, Sexual Awareness, And Comfort With Sexual Discourse In Counselors-In-Training, Katie Adeline Rodenkirch

Graduate Research Theses & Dissertations

Since the initial call to action nearly half a century ago, sexuality training has not been made a core component of counselor education. Despite this, upon graduation counselors are expected to be able to handle diverse client needs, some of which are likely to be sexual in nature. Nevertheless, there is limited research regarding counselor sexuality education or factors influencing counselor-in-training comfort with sexual discourse. The purpose of this research study was to determine the relationship(s) and interaction(s) between counselor-in-training sexuality training experience, sexual awareness, and comfort with sexual discourse. The study also explored group differences based on gender and …

Exploring Beaver-Facilitated Restoration In Grassland Channelized Streams, Jessica L. Sikora

Graduate Research Theses & Dissertations

Freshwater streams provide vital ecosystem services, but their ecological function is gravely impacted by agricultural practices especially in grassland ecosystems. Though there is evidence that the re-introduction of beavers can help restore the ecological function of streams, little is known about their restorative impacts in grasslands. At Nachusa Grasslands Preserve in Franklin Grove, IL, we investigated the presence and impact of beaver dams on their waterways. With increasing beaver dam volume, we found an increase in sediment retention and less sediment retention with increasing beaver dams upstream from a dam. Though we did not find evidence that beaver dam volume …

Faculty Engagement With Universal Design For Learning In The College Classroom, Erin Wilhelm

Graduate Research Theses & Dissertations

The purpose of this qualitative case study was to explore faculty engagement with Universal Design for Learning (UDL) in the college classroom. Specifically, this study sought to uncover how instructors of record of Middleview University (MU) use and experience UDL-based tools and pedagogy. The lived experiences of the participants were examined to reveal any possible challenges, benefits, and level of professional preparedness concerning UDL principles and their application to the classroom.Semi-structured interviews, classroom observations, and the collection of course artifacts and institutional content were the primary sources of data. The findings of this study revealed that, although the participants did …

The Mediating Roles Of Maternal Psychological Distress And Parenting On The Association Between Intimate Partner Violence And Adolescent Delinquent Behavior, Sophie K. Zolinski

Graduate Research Theses & Dissertations

Intimate partner violence (IPV) impacts one in four women in their lifetime, with the reported violence most commonly occurring around childbearing age. Unfortunately, children and adolescents are often unintended victims of IPV, and years of evidence suggest a strong link between maternal IPV and a host of negative adolescent outcomes, including a greater likelihood of engaging in delinquent behavior. Given the negative outcomes linked to adolescent delinquency, the field has been interested in identifying factors that contribute to the association between maternal experiences of IPV and adolescent delinquent behavior, such as the influence of maternal psychological distress and parenting. Many …

Thoughts From A Med Student, Alicia Phillips

The Art of Medicine

No abstract provided.

Homeobox Transcription Factor Hbxa Influences Expression Of Over One Thousand Genes In The Model Fungus Aspergillus Nidulans, Sandesh Sharma Pandit

Graduate Research Theses & Dissertations

In fungi, conserved homeobox-domain (HD) proteins are transcriptional regulators governing development. In Aspergillus species, several HD transcription factor genes have been identified, among them, hbxA/hbx1. For instance, in the opportunistic human pathogen Aspergillus fumigatus, hbxA is involved in conidial production and germination, as well as virulence and secondary metabolism (SM), including production of fumigaclavines, fumiquinazolines, and chaetominine. In the agriculturally important fungus Aspergillus flavus, disruption of hbx1 results in fluffy aconidial colonies unable to produce sclerotia. hbx1 also regulates production of aflatoxins, cyclopiazonic acid and aflatrem. Furthermore, transcriptome studies revealed that hbx1 has a broad effect on the A. flavus …

The Transition Into Higher Education For Students With Autism Spectrum Disorders, Tj Estabrook

Masters Theses

There are more students with autism spectrum disorders (ASD) in higher education now than ever before and these students need to be supported in ways that will guarantee their success. The purpose of this qualitative study was to examine the experiences of six students with ASD as they transition into higher education through the use of semi-structured interviews. What was discovered is that students with ASD typically overestimate the difficulty of academics and underestimate the amount of social interaction they will encounter at the college level. These students are able to identify aspects of themselves that help them to succeed …

Assessing A Byproduct Of The Cbd Ethanol Extraction Process For Potential As A Wood Finishing Product, Avani M. Flanagan

Masters Theses

Developments in regulations concerning the use of CBD products as therapeutic remedies have allowed the global cannabidiol (CBD) market to take off within the past five years. Despite producers of CBD oil wanting to optimize their methods and increase product yields, several waste streams still exist. During the winterization phase of the ethanol extraction process, CBD oil is cooled and filtered so the fats, waxes, and lipids from the Cannabis sativa plant can coagulate and be removed, creating a purer oil with higher potency but contributing to the 58% (crude weight) total loss that occurs throughout the process. The removed …

Development Of A Chemical Biology Approach To Uncover The Influence Of Sequence Variations On Ces1 Activity In Live Cells, Samuel James Knebel

Masters Theses

Drug metabolism is the biochemical process of modifying drugs to detoxify and remove them through enzymatic transformations. These biotransformation’s occur primarily in the liver and are critical to understanding how pharmaceutical compounds are chemically altered inside the human body. Human carboxylesterases (CESs) catalyze the hydrolysis of esters, amides, thioesters, and carbamates. CES-mediated hydrolysis plays an important role in the metabolism of many drugs including the first FDA approved antiviral treatment for COVID-19, remdesivir (Veklury), the seizure control medication rufinamide (Banzel), and the flu antiviral drug oseltamivir (Tamiflu). CES activity is known to be influenced by a variety of factors including …

Wolbachia Infection In Gall Associated Insect Communities In Illinois And Indiana, Jakeb Watts

Masters Theses

Wolbachia is a maternally inherited, gram-negative bacterium and has been found to be associated with up to 60% of all insects, frequently resulting in male-killing, feminization, and cytoplasmic incompatibility in the hosts. Gall wasps and other gall-forming insects induce on various host plants abnormal tissue growths, or plant galls, with distinct morphology. They are considered as obligatory parasites to their host plant. The presence of Wolbachia infection in gall wasp populations in North America has not been extensively documented. Given the strong influence on host reproduction, not knowing Wolbachia infection in insect populations prevents the understanding of how populations are …