Digital Commons Network^™

Characterizing The Regulation Of Candida Albicans Hyphal Morphogenesis In The Context Of Host Macrophages, Hannah Wilson

Dissertations and Theses (Open Access)

Candida albicans is a commensal fungus that resides on the skin, mucosal surfaces, and in the gut of an estimated 80% of individuals. Though generally harmless, C. albicans is capable of causing uncomfortable mucosal infections as well as deadly disseminated infections depending on the immune status of the host. Although antifungal therapeutics exist, the mortality rate associated with disseminated disease still lingers around 50%. Further, C. albicans is the fourth most common cause of all bloodstream infections and continues to present as a major clinical issue with less than satisfactory treatment options. For this reason, it is imperative to understand …

Invasion Control Tangled In Knots: How An Oberlin Student And The Outside World Tackled The Knotweed Problem, Michael E. Harvey

The Synapse: Intercollegiate science magazine

No abstract provided.

Issue 38

The Synapse: Intercollegiate science magazine

No abstract provided.

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

Annual Report 2022-2023, Tennessee. Bureau Of Investigation

Annual Report

No abstract provided.

Computational Molecular Docking Studies Of Small Molecule Inhibitors With The Sars-Cov-2 Spike Protein Variants: In-Silico Drug Discovery Using Virtual Screening And Drug Repurposing Approaches, Grace Gupta

Computational and Data Sciences (MS) Theses

The pandemic caused by the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has caused a global public health crisis of nearly unprecedented scale. In the years following the outbreak, the scientific community has mobilized to develop several vaccines and treatments. Drug repurposing as a strategy for drug development has produced many of the current therapeutic options. The greatest challenge to designing a therapeutic inhibitor of SARS-CoV-2 is the shifting mutational landscape of the virus as it evolves. In this study, we focus on the spike protein as a target for potential inhibitors. We explore two …

Characterization Of Human Fibroblast Growth Factor 2 Variant To Determine Effects On Structure, Stability, And Cell Proliferation, Ryan Layes

Graduate Theses and Dissertations

Fibroblast growth factors (FGFs) are a family of cell signaling proteins conserved across multiple species. Each individual FGF elicits different cellular functions including, but not limited to, proliferation, migration, differentiation, angiogenesis, and wound healing. One of the most studied members, fibroblast growth factor 2 (FGF2), has demonstrated substantial wound healing capacity in a wide range of tissues including skeletal, muscular, neural, respiratory, epithelial, and cardiovascular. This ability makes FGF2 a potential therapeutic for a wide range of conditions and injuries. However, due to a short half-life at room temperature, therapeutic use of FGF2 is limited. It has been demonstrated that …

Wild Sea Cucumber Trade In Rural Madagascar: Consequences For Conservation And Human Welfare, Emily Rothamel, Cortni Borgerson, Delox Rajaona, Be Noel Razafindrapaoly, Be Jean Rodolph Rasolofoniaina, Colette Feehan

Department of Anthropology Faculty Scholarship and Creative Works

Overexploitation of fisheries is a challenge to both marine conservation and human welfare. The trade of sea cucumbers is a multi-billion-dollar market, spanning over 70 countries. Global concern over unsustainable sea cucumber trade led to the inclusion of three species in CITES Appendix II, two of which are found in Madagascar (Holothuria fuscogilva and Holothuria nobilis). We used 792 structured interviews (2015–2020) to study the intensity of wild sea cucumber collection and exportation in rural northeastern Madagascar, where 30% of all (terrestrial and aquatic) native species are threatened with extinction. Wild sea cucumber collection was common and increased tenfold during …

The Role Of Governance In Rewilding The United States To Stem The Biodiversity Crisis, Shelby C. Carlson, John A. Vucetich, L Mark Elbroch, Shelby Perry, Lydia A. Roe, Tom Butler, Jeremy T. Bruskotter

Michigan Tech Publications

A critical but underattended feature of the biodiversity crisis is the contraction of geographic range experienced by most studied terrestrial vertebrates. In the United States, the primary policy tool for mitigating the biodiversity crisis is a federal law, the Endangered Species Act (ESA). For the past two decades, the federal agencies that administer the ESA have interpreted the act in a manner that precludes treating this geographic element of the crisis. Therefore, the burden of mitigating the biodiversity crisis largely falls on wildlife agencies within state government, which are obligated to operate on behalf of the interests of their constituents. …

Analysis Of Non-Kinship Foster Parent Training Needs And Their Support Of Foster Youth: An Occupational Therapy Perspective, Mackenzie King, Pam Kasyan-Howe, Kristin Domville, Amy Paul-Ward

Fall 2023 Virtual OTD Capstone Symposium

This poster discusses the training needs of non-kinship foster parents and how they support the youth in their care. A quantitative survey was used to find relationships between experience fostering and foster parent preparedness or desire for additional training. The survey also included a section for participants to write down their training needs; themes from this question are found on the poster. The poster further discusses future recommendations and implications for OT practice in working with this population.

Phylogenomics Reveals The History Of Host Use In Mosquitoes, John Soghigan, Charles Sither, Silvia Andrade Justi, Gen Morinaga, Brian K. Cassel, Christopher J. Vitek, Todd P. Livdahl, Siyang Xia, Andrea Gloria-Soria, Jeffrey R. Powell, Thomas Zavortink, Christopher M. Hardy, Nathan D. Burkett-Cadena, Lawrence E. Reeves, Richard C. Wilkerson, Robert R. Dunn, David K. Yeates, Maria Anice Sallum, Brian D. Byrd, Michelle D. Trautwein, Yvonne-Marie Linton, Michael H. Reiskind, Brian M. Wiegmann

Biology

Mosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and limited availability of genomic data beyond the most important vector species. Here, we used phylogenomic analysis of 709 single copy ortholog groups from 256 mosquito species to produce a strongly supported phylogeny that resolves the position of the major disease vector species and the major mosquito lineages. Our analyses support an origin of mosquitoes in the early Triassic (217 MYA [highest posterior density region: …

Process-Structure-Property Relationships Of Nanofibers For Biomedical Applications, Dipasree Bhowmick

Theses and Dissertations

This thesis explores the fabrication, characterization, and applications of nanofiber membranes utilizing Forcespinning® technology. Two distinct nanofiber systems were developed and evaluated, one focusing on pH-responsive Eudragit-baicalin loaded nanofibrous membranes for wound healing and the second one on thermo-responsive nanofiber-hydrogel (PNIPAAm) systems for biosensing applications, specifically dopamine detection. In the first project, nanofiber membranes loaded with Eudragit and baicalin demonstrated superior antibacterial properties against both gram-negative (E. coli) and gram-positive (B. meg) bacteria. Additionally, these membranes exhibited antioxidant properties and enhanced cell proliferation of 3TT cells, making them promising candidates for wound healing dressings. In the second project, a …

Monitoring The Effectiveness Of Wildlife Exits And Bobcat Use Along A South Texas Highway, Jamie E. Langbein

Theses and Dissertations

Roadside exclusion fencing is commonly used to mitigate wildlife road mortalities and property damages caused by wildlife-vehicle collisions. A potential consequence is that animals may become trapped on the road by fencing. On State Highway 100 in South Texas, the Texas Department of Transportation installed ten wildlife exits (WE) allowing animals to exit the roadway through a modified opening in the fence. However, some individuals used the WE to access the roadway. In this study, a new design was implemented, with narrower openings, a ramp and a clear plastic one-way door. While the updated design prevented road access for wildlife, …

Examining Social Factors Influencing Latino Students' Academic Learning In Rio Grande Valley Via A Quantitative Design, David T. Smith

Theses and Dissertations

This research study aimed to examine the social factors that could influence the academic learning experiences of Latino college students. Hispanic students are pursuing post-secondary degrees at a higher rate than in previous years. Many Hispanics represent their respective family members as the first members of their respective families to attend college (Trevino & DeFreitas, 2014). The academic achievement of Latino college students is becoming a major concern in the United States due to their growing population and special needs (Trevino & DeFreitas, 2014).

It is imperative to examine the social factors that could affect the academic learning experiences of …

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian

Biomedical Engineering: Graduate Reports and Projects

As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …

Fabrication Of Pvc Enrofloxacin-Selective Electrodes For Estimating Enrofloxacin In Pure Form And As Preparation Formula, Omar Salih Hassan, Sahar S M Alabdullah, Amina M. Abass, Ahmed Ahmed

Baghdad Science Journal

This study explored the development and qualities of the response of electrochemical properties of enrofloxacin-selective electrodes using precipitation based on producing phosphotungstic, after utilizing a matrix of polyvinyl chloride (PVC) and dibutyl phthalate or dibutyl phosphate as a plasticizer. The resulting membrane sensors were an enrofloxacin-phosphotungstic electrode (sensors 1) and an ENR-DOP-PTA electrode (sensors 2). Linear responses of (ENR-DBPH-PTA) and (ENR-DOP-PTA) within the concentration ranges of 2.1×10-6-10-1 and 3.0×10-6-10-2 mol. L-1, respectively, for both sensors were observed. Slopes of 51.61±0.24 and 39.40± 0.16 mV/decade and pH ranges equal to 2.5-8.5 and 2.0-9.0 were observed for sensors 1 and 2, respectively. …

Bisexuality, Biphobia, And Its Effects On Sexual Identity, Religious Identity And Mental Health: Examining Clinical Implications, Diana Ramirez

Dissertations

Bisexuality is a sexual orientation, sometimes known as “bi,” that includes sexuality in which certain people are attracted to more than one sex and gender. Bisexuality differs from other sexual- and gender-nonconforming experiences (McInnis et al., 2022). According to Ross et al. (2018), bisexuality is frequently described as an invisible sexual orientation, and only in the last 20 years has research on biphobia and bisexuality increased (McInnis et al., 2022). Experiences unique to bisexuality include bisexual invisibility from a societal level (Dyar et al., 2015), bisexuals are more prone to experience sexual orientation instability (Bostwick et al., 2014), and bisexual …

Self Portraits: How The Arts May Be The Key To Equitable And Authentic Engagement For Culturally And Linguistically Diverse Student Populations, Betsy Sostak

Dissertations

As the linguistic and cultural diversity across America’s classrooms steadily increases, educators are searching for ways to meet the needs of their students. The linguistic and cultural resources our students bring are a tremendous asset, yet our country has not been able to fully realize the potential of a diverse population. While multilingual students are often perceived to lack background knowledge, connections to school, and linguistic resources, the arts have the capacity to increase engagement, connect to diverse cultural backgrounds, and transcend language barriers. In this study, I explore the ways in which educational equity may be achieved to a …

Chronic Stressors, Obesity Pathogenesis, And The Moderating Effect Of Internalized Weight Stigma; A Quantitative, Illinois Study, Karyn Byrne

Dissertations

The obesity epidemic is a ‘wicked’ problem with a complex web of determinants and outcomes. While generally higher for minoritized populations, prevalence rates manifest in surprising, nonlinear patterns. There is no consensus regarding treatment protocols or mitigation efforts, except that current efforts remain largely ineffective. Much research evidence that a profusion of determinants of health support obesity pathogenesis through various physiological processes and mechanisms, including the allostatic load, mitochondria functioning, the gut microbiome, and epigenetics. Intervening to support markers of the allostatic load (immunity, inflammation, and metabolic health) may provide a more effective treatment outcomes than traditional approaches, which tend …

A Multisociety Delphi Consensus Statement On New Fatty Liver Disease Nomenclature, Mary E. Rinella, Samuel Klein, Et Al.

2020-Current year OA Pubs

The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favor of a change in nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. The consensus was defined a priori as a supermajority (67%) vote. An independent committee of experts external to the nomenclature process made the final recommendation on the acronym and its diagnostic criteria. A total of 236 panelists from 56 countries participated in 4 …

Exosomal Tar Dna Binding Protein 43 Profile In Canine Model Of Amyotrophic Lateral Sclerosis: A Preliminary Study In Developing Vlood-Based Biomarker For Neurodegenerative Diseases, Penelope Pfeiffer, Joan R. Coates, Yajaira M. Esqueda, Andrew Kennedy, Kyleigh Getchell, Myra Mclenon, Edina Kosa, Abdulbaki Agbas

Faculty and Staff Publications

Objective: Blood-based biomarkers provide a crucial information in the progress of neurodegenerative diseases with a minimally invasive sampling method. Validated blood-based biomarker application in people with amyotrophic lateral sclerosis would derive numerous benefits. Canine degenerative myelopathy is a naturally occurring animal disease model to study the biology of human amyotrophic lateral sclerosis. Serum derived exosomes are potential carriers for cell-specific cargoes making them ideal venue to study biomarkers for a variety of diseases and biological processes. This study assessed the exosomal proteins that may be assigned as surrogate biomarker that may reflect biochemical changes in the central nervous system.

Methods: …

Tumor Treating Fields: Narrative Review Of A Promising Treatment Modality For Cancer, Tugce Kutuk, Alonso La Rosa De Los Rios, Rupesh Kotecha, Minesh Mehta, Michael Chuong

All Publications

Background and objective: Tumor treating fields (TTFields) therapy have emerged as a potentially effective treatment for various malignancies by delivering low-intensity, intermediate-frequency electrical fields that disrupt many processes inside cells, resulting in the interruption of cell division in cancer cells. Additionally, TTFields therapy has been found to be synergistic with existing therapeutic approaches. In this review, we provide an introduction and background to the primary mechanisms of TTFields and discuss the emerging preclinical and clinical outcomes of this novel cancer treatment technology.

Methods: We performed a literature search on PubMed, ClinicalTrials.Gov, and Google Scholar using the terms 'TTFields' and 'cancer'. …

Analyses Of Mybl1 In Triple Negative Breast Cells And Validation Of Genes Colocalized To Chromosome 8q Loci, La Tajia D. Thirston

Theses (2016-Present)

Fifteen percent of breast cancer are characterized as the triple negative breast cancer subtype. The cancers are recognized as negative for estrogen, progesterone and ErRB2 receptors, genes that function as transcription and growth factor functions, respectively. Previous data show the MYBL1 transcription factor is over-expressed in some triple negative breast cancers-suggesting dysregulation of the gene in the cancers. MYBL1 gene is a strong transcriptional regulator associated with regulation of cell cycle proliferation which is a key event in cancer progression. To determine genes either directly or indirectly associating with MYBL1 in these cancers we knocked the gene down, performed microarray …

Disrupting Childhood Trauma With Holistic Health Practices In Low Ses Elementary Schools, Unna G. Burns, Ketzia Kogan, Sarah M. Wingerden, Hannah Meck

Psychology and Child Development

It is evident that adverse childhood experiences (ACE) are a large challenge to tackle in the U.S., with 61% of adults reporting that they’ve experienced one ACE and 16% reporting four or more ACEs by age 18 (Centers for Disease Control and Prevention, 2019). ACE score items include, but are not limited to experiencing verbal, physical, sexual abuse, physical and/or emotional neglect, having a mentally ill family member, witnessing violence in the home towards a parent, and/or having a family member in prison. Such experiences serve as a public health threat that, without early intervention, bring about long-term effects biologically, …

From Periphery To Center: Re-Presenting Black And Afro-Arab Characters In Contemporary Arabic Literature, Samer Ahmad Mayyas

Graduate Theses and Dissertations

Black Arabs and Afro-Arabs tend not to be centered in Arabic discourse, especially modern Arabic literature, and Black people of other ethnicities are marginalized, as if Black peoples and Afro-Arabs were not part of the history and present-day of the Arabic-speaking world. I explore in this dissertation project the representations and experiences of Black and Afro-Arabs in contemporary Arabic fictional narratives. I argue that the contemporary literary era sees a shift in re-presenting Black peoples and Afro-Arabs in the Arabic fictional discourse. By moving Black and Afro-Arab characters from periphery to center, contemporary Arab writers challenge and disrupt, in an …

A Model Of Immediate Implant Placement To Evaluate Early Osseointegration In 129/Sv Diabetic Mice, Cláudia Cristina Biguetti, Alexandra Arteaga, Bhuvana Lakkasetter Chandrashekar, Evelin Rios, Ryan Margolis, Danieli C. Rodrigues

School of Podiatric Medicine Publications

Purpose: To analyze the process of early oral osseointegration of titanium (Ti) implants in diabetic 129/Sv mice through microCT and histologic and immunohistochemical analysis.

Materials and methods: A group of 30 male 129/Sv mice was equally subdivided into two groups: (1) nondiabetic (ND), in which mice did not undergo systemic alterations and received a standard diet, and (2) diabetic (D), in which mice were provided a high-fat diet from the age of 6 weeks until the conclusion of the study and received two intraperitoneal (IP) injections of streptozotocin (STZ) at a concentration of 100 mg/Kg each. Each mouse underwent extraction …

Community-Based Cultivation Of Medicinal Plants: Preserving Florida's Native Plants, Shayna Dimmer

USF St. Petersburg campus Honors Program Theses (Undergraduate)

This thesis explores the role of community-based cultivation of native medicinal plants as a strategy for promoting conservation, cultural awareness, and public health in Florida. Through a review of ethnobotanical literature and a hands-on case study conducted in a St. Petersburg community garden, the research documents the process of identifying, sourcing, propagating, and integrating two Florida native medicinal species, Passiflora incarnata (purple passionflower) and Callicarpa americana (American beautyberry), into a community setting. The study examines the historical and contemporary significance of medicinal plants, the challenges posed by overharvesting and habitat loss, and the growing need for sustainable cultivation practices. Findings …

Intersectionalities In Internationalization Studies: An Overview Of Brazilian Research, Simone M. Costa, Lauro Sérgio M. Pereira, Kléber A. Silva

Journal of Comparative & International Higher Education

Special Issue

Post-Wildfire Export Regimes Of Solutes Along The Gallinas-Pecos River-Santa Rosa Fluvial Network, Asmita Kaphle

Civil Engineering ETDs

Wildfires significantly contribute to water pollution when ash and sediments, including nutrients and metals, are released into fluvial systems, impacting aquatic ecosystems and surrounding communities. This study focuses on the impacts of the Hermits Peak-Calf Canyon Fire on the Gallinas and Pecos watersheds. It employs five monitoring stations along a 190km fluvial network to assess solute export regimes post-fire, where grab samples were collected for nutrient and metal analyses for a period of more than a year. The metrics used for characterizing mobilization, chemostatic, or dilution patterns indicated mobilization for most solutes at all sites upstream of Santa Rosa Lake. …

Preparing Teaching Assistants To Facilitate Course-Based Undergraduate Research Experiences (Cures) In The Biological Sciences: A Call To Action, Erin Shortlidge, Amie M. Kern, Emma Goodwin, Jeffrey T. Olimpo

Biology Faculty Publications and Presentations

Course-based undergraduate research experiences (CUREs) offer an expanding avenue to engage students in real-world scientific practices. Increasingly, CUREs are instructed by graduate teaching assistants (TAs), yet TAs may be underprepared to facilitate and face unique barriers when teaching CUREs. Consequently, unless TAs are provided professional development (PD) and resources to teach CUREs effectively, they and their students may not reap the assumed benefits of CURE instruction. Here, we describe three perspectives – that of the CURE TA, the CURE designer/facilitator, and the CURE student – that are collectively intended to inform the development of tentative components of CURE TA PD. …