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Deficiency Of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality And Lung Injury In Mice, Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Luke W. Meredith, Brittany Dong, Qian Wang, Ling Guo, Xiangan Li, Frederick C. De Beer, Nancy R. Webb, Lisa R. Tannock, Marlene E. Starr, Christopher M. Waters, Preetha Shridas

Saha Cardiovascular Research Center Faculty Publications

Serum amyloid A (SAA) is a family of proteins, the plasma levels of which may increase >1000-fold in acute inflammatory states. We investigated the role of SAA in sepsis using mice deficient in all three acute-phase SAA isoforms (SAA-TKO). SAA deficiency significantly increased mortality rates in the three experimental sepsis mouse models: cecal ligation and puncture (CLP), cecal slurry (CS) injection, and lipopolysaccharide (LPS) treatments. SAA-TKO mice had exacerbated lung pathology compared to wild-type (WT) mice after CLP. A bulk RNA sequencing performed on lung tissues excised 24 h after CLP indicated significant enrichment in the expression of genes associated …

Loss Of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids And Drives Sexually Dimorphic Liver Disease In Mice, Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley

Saha Cardiovascular Research Center Faculty Publications

Background and aims: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic lipid metabolism.

Approach and results: Male and female liver-specific knockout (LKO) and littermate controls were placed on a low-fat or high-fat diet (60% kcal fat) for 15 weeks. Mice were necropsied after a 16 h fast, and tissues were collected for lipidomics, matrix-assisted laser desorption ionization mass spectrometry imaging, kinome analysis, RNA-sequencing, and protein expression by immunoblotting. Female LKO mice had increased serum alanine …

A Descriptive Analysis Of Gastric Cancer With An Immunohistochemical Study Of Ki67 And P53 As Prognostic Factors.: Bahrain Experience, Mohmmed Awadh, Aysha Darwish, Huda Alqatari, Fatema M. Buzaid, Abdulla Darwish

Saudi Medical Journal

Objectives: To describe the increasing number of gastric cancer cases at Bahrain Defense Force Hospital with implementation of immunohistochemistry markers as prognostic factors. Methods: This study included histologically confirmed malignant gastric tumors diagnosed at Bahrain Defense Force Hospital from January 2009 to June 2019. Various epidemiological and pathological data were abstracted and recorded with immunohistochemical analysis of the proliferation marker Ki67 and cell-cycle regulator p53 as prognostic factors. Results: A total of 53 patients with gastric cancer were included in the study, with mean age of 59.75 ± 12.9 years. The typical histological types were signet ring cell adenocarcinoma (68%) …

An Exploration Into Health Equity Discourse In Mississippi: Organizational Commitments And Practitioner Perspectives, Thuy-Vy Lillian Pham

Honors Theses

This thesis takes a sociological approach to examine healthcare workers' beliefs and medical organizations’ solidarity statements related to diversity and equity and how these discourses aligned and/or diverged. Through interviews with healthcare providers in Mississippi and content analysis of solidarity statements, the study finds that discussions on health disparities more frequently addressed socioeconomic inequality rather than systemic racism, diverging from organizational statements. This emphasis may partly stem from the demographics of the study participants, who were predominantly White—which also reflected the staff where they worked. Additionally, while healthcare workers recognized structural issues related to health disparities, they often showed hesitancy …

Investigating The Relationship Between Consistent Workout Regimen On Quality Of Life Among Crossfitters In South Mississippi, Christian Glass

Honors Theses

Robust literature exists to support the utility of CrossFit in improving metabolic and cardiovascular well-being. However, a metaphorical chasm exists not in the study of the physiological effects of CrossFit but in the psychological effects, namely quality of life (QOL). This thesis aimed to offer an installment into this gap by investigating trends among a population of 81 CrossFitters in south Mississippi. To best fulfill this task, a quantitative study was conducted using a 32-item survey composed of a mixture of questions from the World Health Organization Quality of Life Brief Version (WHOQOL- BREF) to assess reported quality of life …

An Emergent Genealogy Of Kahuku’S Contested Red Raider Mascot, Kali Fermantez, Lisa Uperesa

Pacific Studies

No abstract provided.

Vol. 46 No. 2 (2023): Pacific Studies Full Issue, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Pacific Studies is published two times a year by The Jonathan Nāpela Center for Hawaiian and Pacific Studies, Brigham Young University Hawai‘i #1979, 55–220 Kulanui Street, Lā ‘ie, Hawai‘i 96762, but responsibility for opinions expressed in the articles rests with the authors alone. Subscription rate is US$40.00 yearly, payable to The Jonathan Nāpela Center for Hawaiian and Pacific Studies. The Jonathan Nāpela Center for Hawaiian and Pacific Studies (formerly The Pacific Institute) is an organization funded by Brigham Young University Hawai‘i. The Center assists the University in meeting its cultural and educational goals by undertaking a program of teaching, research, …

(Wp 2023-06) Richard Arena On Sraffa And Wittgenstein, John B. Davis

Economics Working Papers

This paper discusses Richard Arena’s insightful and original contributions to interpreting the important interaction between Piero Sraffa and Ludwig Wittgenstein. It discusses this in terms of dilemmas they each encountered in transitions in their thinking in the 1930s, emphasizes the influence of Sraffa’s unpublished “Surplus Product” text, compares Sraffa’s critique of “natural science point of view” and Wittgenstein’s critique of logical form, and compares Sraffa’s later understanding of the relationship between production and distribution and Wittgenstein’s later understanding of forms of life and language-games. The paper argues this thinking opened up a approach to economic philosophy in connection with the …

An Examination Of The Intersection Between Gender And The Experiences Of Female Adventure Tour Guides In Tanzania, Ellen Koppa

All Dissertations

Tourism may be a source of growing gender inequity in some tourist setting due to their cultural and historical contexts even though it is a potential instrument for improving the welfare of women through employment and entrepreneurial activities. Many studies have focused on the role of tourism in improving the lives of women in Tanzania, but few have focused on women employed in male dominated positions like adventure tour guiding. While being a female tour guide is regarded as a big achievement in Tanzania with many women wanting to be tour guides, there are very few female tour guides in …

An Integrative Approach To Managing A Species Of Conservation Concern: Resource Selection, Spatial Ecology, And Population Genetics Of The Green Salamander (Aneides Aeneus), Megan Novak

All Dissertations

The relationship between wildlife and the environment they inhabit is dependent on both spatial and temporal scales. It is therefore crucial that biological investigations account for ecological scale when analyzing patterns and processes established, particularly when such investigations inform conservation management plans. This dissertation provides extensive insight into the conservation biology of the green salamander (Aneides aeneus), a critically imperiled species in South Carolina. The green salamander is a species that exists in a patchy network of rock outcrops within mountainous forest landscapes, and most studies on habitat suitability for green salamanders have been conducted on the macrohabitat, …

Vehicle-Bridge Interaction Simulation And Damage Identification Of A Bridge Using Responses Measured In A Passing Vehicle By Empirical Mode Decomposition Method, Shohel Rana, Md. Rifat Zaman, Md. Ibrahim Islam Ifty, Seyedali Mirmotalebi, Tahsin Tareque

Civil Engineering Faculty Publications

To prevent early bridge failures, effective Structural Health Monitoring (SHM) is vital. Vibration-based damage assessment is a powerful tool in this regard, as it relies on changes in a structure’s dynamic characteristics as it degrades. By measuring the vibration response of a bridge due to passing vehicles, this approach can identify potential structural damage. This dissertation introduces a novel technique grounded in Vehicle-Bridge Interaction (VBI) to evaluate bridge health. It aims to detect damage by analyzing the response of passing vehicles, taking into account VBI. The theoretical foundation of this method begins with representing the bridge’s superstructure using a Finite …

Traumatic Consequences In Native Hawaiians After Colonization, Andrea Morland-Tellez, Elizabeth Drummond

Honors Thesis

The Native Hawaiian population is a marginalized group that has endured cultural trauma due, in part, to their history of colonization by Europe in 1778. This colonization has contributed to the Native Hawaiian’s loss of cultural identity, land, native language, and their way of life. As a result, many Native Hawaiians are left questioning their cultural identity. This project sought to better understand the impact of colonization on the Native Hawaiian people, specifically on their experience of homelessness, substance use, and overall disempowerment over time. A systematic review of multiple literary and anecdotal sources was conducted including peer- reviewed articles …

Library News December 2023, Research Medical Library

Library News 2023

• Interpreting iThenticate Reports
• Creating Accessible Hyperlinks
• Research Fronts 2023: Annual Report
• Are There Any Times We Should Use “Anytime” Instead of “Any Time”?
• Biocyc: a Pathway/Genome Database Collection
• Must Read Books of 2023

Of Corpses And Persons: Examining A Cadaver As An Object And Subject Of Rights, Arseny Shevelev, Georgy Shevelev

Louisiana Law Review

No abstract provided.

Carbon Sequestration: A Pipedream Or The Solution To Global Warming?, Caroline Mccullars

Louisiana Law Review

No abstract provided.

Putting Dance In Triple Threat: Confidence And Knowledge Of Dancing In Middle School Actors, Miranda Taylor

Master's Theses

The purpose of this study is to alleviate feelings of inadequacy in middle school musical theater actors through gained dance knowledge and confidence. The researcher evaluated middle school actors throughout the rehearsal process of a musical. The goal was to answer these three essential questions: Q1 Does feeling confident on stage as an actor/singer correlate with being a confident dancer? Q2 How can dance and choreography be used to increase confidence? Q3 How does previous dance experience effect confidence during a musical? Pre and post questionnaires were given to students who were cast in the show. The data suggested that …

Investigating The Therapeutic Potential Of Cannabigerol (Cbg) In Female Nonalcoholic Steatohepatitis (Nash) Mouse Model, Raznin A. Joly

Master's Theses

Nonalcoholic Steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by inflammation, fibrosis, steatosis, and oxidative stress, in addition to excessive fat accumulation in the liver. Cannabigerol (CBG), a precursor molecule of Cannabidiol (CBD), has demonstrated anti-inflammatory and anti-oxidative effects in various studies. Our previous data showed that a low dosage of CBG reduced inflammation and fibrosis in male NASH mice. However, the impact of CBG on female mice remains unknown. Recent studies have identified changes in immune cell populations in NAFLD patients. The goal of this project was to test the impact of CBG treatment …

On The Origin And Evolution Of The Mosquito Male-Determining Factor Nix, James K. Biedler, Azedah Aryan, Yumin Qi, Aihua Wang, Ellen O. Martinson, Daniel A. Hartman, Fan Yang, Atashi Sharma, Katherine S. Morton, Mark Potters, Chujia Chen, Stephen L. Dobson, Gregory D. Ebel, Rebekah C. Kadling, Sally Paulson, Rui-De Xue, Michael R. Strand, Zhijian Tu

Entomology Faculty Publications

The mosquito family Culicidae is divided into 2 subfamilies named the Culicinae and Anophelinae. Nix, the dominant male-determining factor, has only been found in the culicines Aedes aegypti and Aedes albopictus, 2 important arboviral vectors that belong to the subgenus Stegomyia. Here we performed sex-specific whole-genome sequencing and RNAseq of divergent mosquito species and explored additional male-inclusive datasets to investigate the distribution of Nix. Except for the Culex genus, Nix homologs were found in all species surveyed from the Culicinae subfamily, including 12 additional species from 3 highly divergent tribes comprising 4 genera, suggesting Nix originated at least 133 to …

Genome-Wide Significant Risk Loci For Mood Disorders In The Old Order Amish Founder Population, Elizabeth M. Humphries, Kwangmi Ahn, Rachel L. Kember, Fabiana L. Lopes, Evelina Mocci, Juan M. Peralta, John Blangero, David C. Glahn, Fernando S. Goes, Peter P. Zandi

School of Medicine Publications

Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts have identified numerous risk loci, yet pathophysiological mechanisms remain elusive, primarily due to the very small effects of common variants. We sought to discover risk variants with larger effects by conducting a genome-wide association study of mood disorders in a founder population, the Old Order Amish (OOA, n = 1,672). Our analysis revealed four genome-wide significant risk loci, all of which were associated with >2-fold relative risk. Quantitative behavioral and neurocognitive assessments (n = 314) revealed effects of risk variants on sub-clinical depressive symptoms and information processing speed. …

Muc13 Drives Cancer Aggressiveness And Metastasis Through The Yap1-Dependent Pathway, Kyle Doxtater, Manish Tripathi, Radhiki Sekhri, Bilal B. Hafeez, Sheema Khan, Nadeem Zafar, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Anchorage-independent survival after intravasation of cancer cells from the primary tumor site represents a critical step in metastasis. Here, we reveal new insights into how MUC13-mediated anoikis resistance, coupled with survival of colorectal tumor cells, leads to distant metastasis. We found that MUC13 targets a potent transcriptional coactivator, YAP1, and drives its nuclear translocation via forming a novel survival complex, which in turn augments the levels of pro-survival and metastasis-associated genes. High expression of MUC13 is correlated well with extensive macrometastasis of colon cancer cells with elevated nuclear YAP1 in physiologically relevant whole animal model systems. Interestingly, a positive correlation …

A Sound Mind In A Sound Body: A Novel Concept Unravelling Heterogeneity Of Depression, Gabor Hullam, Zsofia Gal, Xenia Gonda, Tamas Nagy, Andras Gezsi, Isaac Cano, Sandra Van Der Auwera, Mikko Kuokkanen, Peter Antal, Gabriella Juhasz

School of Medicine Publications

Depression is a highly prevalent and debilitating condition, yet we still lack both in-depth knowledge concerning its etiopathology and sufficiently efficacious treatment options. With approximately one third of patients resistant to currently available antidepressants there is a pressing need for a better understanding of depression, identifying subgroups within the highly heterogeneous illness category and to understand the divergent underlying biology of such subtypes, to help develop and personalise treatments. The TRAJECTOME project aims to address such challenges by (1) identifying depression-related multimorbidity subgroups and shared molecular pathways based on temporal disease profiles from healthcare systems and biobank data using machine …

Whole-Genome Sequencing Uncovers Two Loci For Coronary Artery Calcification And Identifies Arse As A Regulator Of Vascular Calcification, Paul S. De Vries, Matthew P. Conomos, Kuldeep Singh, Christopher J. Nicholson, Deepti Jain, Natalie R. Hasbani, Wanlin Jiang, Sujin Lee, Christian L. Lino Cardenas, Sharon M. Lutz, John Blangero

School of Medicine Publications

Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four known loci and identified two additional loci associated with CAC (ARSE and MMP16), with evidence of significant associations in replication analyses for both novel loci. Functional assays of ARSE and MMP16 in human vascular smooth muscle cells (VSMCs) demonstrate that ARSE is a promoter of VSMC calcification and VSMC phenotype switching from a contractile to a calcifying or osteogenic phenotype. …

Metabolic Phenotyping Of Bmi To Characterize Cardiometabolic Risk: Evidence From Large Population-Based Cohorts, Habtamu B. Beyene, Corey Giles, Kevin Huynh, Tingting Wang, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Gerald F. Watts, John Blangero

School of Medicine Publications

Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with metabolic disorders giving rise to the concept of “metabolically healthy obese”. We use lipidomic-based models for BMI to calculate a metabolic BMI score (mBMI) as a measure of metabolic dysregulation associated with obesity. Using the difference between mBMI and BMI (mBMIΔ), we identify individuals with a similar BMI but differing in their metabolic health and disease risk profiles. Exercise and diet associate with mBMIΔ …

The Use Of Stem Gaming To Promote Hearing Health In Youth, Catelyn D. Tweeten

Doctoral Scholarly Projects & Capstones

Hearing loss prevention programs targeting youth have been implemented in many forms to teach younger populations about hearing health to prevent noise-induced hearing loss. Some hearing loss prevention programs, such as Dangerous Decibels®, are based on health communication science and aim to not only increase youth’s knowledge about noise-induced hearing loss, but positively change their attitudes, beliefs, and behaviors towards safe listening practices. The purpose of this project was to investigate how an educational computer game called Song of the Starbird could potentially be used as an effective hearing health promotion tool for students with normal hearing and students with …

Examining The Microbial Diversity Of A Generalist Ant Along An Urban-Rural Gradient, Abdol-Munim Abazid

Honors Theses

After sampling the exoskeleton microbiomes of 225 ants from 3 different locations along a rural-urban gradient in the Chattanooga area, a photo library was collected and microbial diversity and morphospecies evenness of each location was determined. It was determined that there was no significant difference in either microbial diversity or morphospecies evenness between sites along the rural-urban gradient, even after adjusting data to be between only rural and urban areas. Urbanization was quantified using % impervious surface; however, a future study could quantify urbanization by other means, such as soil nutrient composition. Additionally, it was determined that there was no …

From Blue Skies To Gray Areas: Examining Privacy And Property Law In The Age Of Drone Technology, Cheng-Chi (Kirin) Chang

Richmond Journal of Law & Technology

This article presents a comprehensive analysis of the legal frameworks governing the use of drones in both the United States and the European Union, and the privacy and property rights issues that arise from their use. The article emphasizes the importance of balancing the benefits of drone technology with the protection of individual rights. The regulatory frameworks governing drones are compared between the two jurisdictions, highlighting key similarities and differences. Furthermore, the article delves into the legal challenges surrounding drone usage and property rights, offering several solutions to address privacy concerns. In conclusion, the article highlights the need for a …

Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee

Electronic Theses and Dissertations

We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …

Breaking Virulent: The Coincidental Evolution Of Virulence Factors In Bacteria., Rhiannon Emmanuelle Cecil

Electronic Theses and Dissertations

Understanding how innocuous organisms can evolve to be pathogenic to humans is of increasing global concern. Further, understanding how existing pathogens may evolved to be more virulent is also vital to our ability to provide healthcare to people afflicted with diseases that promote chronic bacterial infections, such as cystic fibrosis. With the rise of antibiotic resistance in both bacteria and fungi it is paramount that new therapeutics are identified. Understanding what mutations occur that result in increased virulence in microbes can potentially provide new targets for antimicrobial drugs to combat antibiotic resistance. The Coincidental Evolution Hypothesis is a fundamental hypothesis …

A Study Of Group Effectiveness In A Virtual Reality Environment., Dalton Clay Sparks

Electronic Theses and Dissertations

Virtual Reality (VR) technology has revolutionized the study of team effectiveness, yet many studies in this domain lack a comprehensive approach, focusing narrowly on performance metrics. This thesis investigates VR team effectiveness by integrating traditional Team Effectiveness frameworks with VR-specific dynamics. Utilizing Data Envelopment Analysis (DEA) and Group Style Inventory (GSI), this study assesses teams within a VR environment, specifically a multiplayer submarine simulation game, IronWolfVR. Fifteen groups, totaling 45 participants, were observed for their collaborative gameplay, incorporating physiological measures (Heart Rate and Electrodermal Activity), team coordination dynamics, and various survey-based assessments (demographics, System Usability Scale, Simulator Sickness Questionnaire, and …

From "Smart Talk" To "Living Well": Commonplaces And Their Role In Narratives Of Rare Disease., Caitlin E. Ray

Electronic Theses and Dissertations

As healthcare becomes more complex, automated, and bureaucratic, patients often suffer from a lack of resources, agency, and visibility when seeking medical care. Rhetoric and Composition, specifically the subfield of Rhetoric of Health and Medicine (RHM), is interested in studying and intervening into such issues. One way to challenge our current understanding of healthcare is to consider how the rare disease patient experience reveals the gaps, limitations, and assumptions of illness and health. I argue here that through rare diseases, rhetoricians of health and medicine can better understand the representation, advocacy, and patient experience within healthcare, and potentially lead to …