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Gpcrs And Fibroblast Heterogeneity In Fibroblast-Associated Diseases, Nidhi V. Dwivedi, Souvik Datta, Karim El-Kersh, Ruxana Sadikot Md, Mrcp, Apar Kishor Ganti, Surinder K. Batra, Maneesh Jain

Journal Articles: Biochemistry & Molecular Biology

G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of "most targeted receptors". About one-third of the commercially available drugs for various diseases target the GPCRs. Fibroblasts lay the architectural skeleton of the body, and play a key role in supporting the growth, maintenance, and repair of almost all tissues by responding to the cellular cues via diverse and intricate GPCR signaling pathways. This review discusses the dynamic architecture of the GPCRs and their intertwined signaling in pathological conditions such as idiopathic …

Interactive Association Of Posttraumatic Stress Disorder, Apolipoprotein Ε4 Genotype, And Age On Cognitive Functioning, Karen A. Lawrence, Colton Rippey, Bianca Welikson, Robert H. Pietrzak, Thomas G. Adams Jr.

Psychology Faculty Publications

Background: The ε4 allele of the apolipoprotein (APOE) gene and posttraumatic stress disorder (PTSD) are associated with cognitive deficits. Both associations may vary depending on age. No previous study has examined a possible three‐way interaction between APOE ε4, PTSD, and age on cognitive functioning.

Methods: Data were analyzed from 1244 European‐American U.S. military veterans who participated in the 2011 National Health and Resilience in Veterans Study (NHRVS). Analyses of covariance were used to examine the main effects and in- teractions of APOE ε4, PTSD, and age on learning/working memory (LWM) and attention/psychomotor (APM) performance.

Results: A significant three‐way interaction between …

Detecting Children's Dental Caries Risk Through Finger-Digit Ratio, Syakriani Syahrir, Andi S. Permatasari, Aini I. Baiduri, Syamsiah Syam, Yayah Inayah

Journal of Dentomaxillofacial Science

No abstract provided.

Nebraska Summary: S1256 Fendt 722 Vario Gen7, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Catalog Revision Gen Ed, Academic Affairs

Executive Actions

No abstract provided.

Reconstructing The Germination Pathway From The Rafflesia Seed Transcriptome, Venkata Siva Sankar Maddu

Selected Full-Text Master Theses 2021-

Rafflesia (Rafflesiaceae) produces the largest flowers in the world but has no stems, roots, or leaves. It is a holoparasitic angiosperm that derives all its nutrients from its host vine, Tetrastigma. All species are also threatened with extinction, but propagating it has been incredibly challenging. Its germination from seed has never been observed. The thesis aims to reconstruct the germination pathway of Rafflesia from its published seed transcriptome to gain insight into its molecular genetics and understand what germination genes can be stimulated to facilitate infection of its host for ex-situ propagation. The published seed transcriptome of Rafflesia speciosa was …

Pharmaceuticals From Natural Products: The Utility Of The Phylogeny, Shaimaa Magdy Saad

Selected Full-Text Master Theses 2021-

About 60% of approved drugs during the last 30 years are either directly or indirectly from natural products. Previous studies have shown that the phylogeny has predictive utility in drug discovery. In this study the pharmacological applications of various naturally-derived drugs were mapped on the phylogeny reconstructed from DNA sequences of the source organisms to decipher phylogenetic patterns that may facilitate drug discovery. A multi-step approach was employed starting with a literature search to compile a comprehensive list of pharmaceutical drugs derived from natural sources. A phylogeny was reconstructed from the source organisms and their pharmacological uses mapped on the …

General Education Catalogue Revisions, Academic Affairs

Program Revisions/Additions

No abstract provided.

Laid To Rust: Proposing Strict Liability In Tort For Prop Firearm Injuries Following The Alec Baldwin Shooting, Mark Edward Blankenship Jr., Joseph A. Ott

Nevada Law Journal Forum

Prop gun safety standards are often a mixed bag. “Despite some industry reforms following previous tragedies, the federal workplace safety agency in the U.S. is silent on the issue of on-set gun safety.” Some states follow film labor union and movie studio guidelines. Other states have regulations on pyrotechnic devices, but not on prop guns. Thus, states should consider what successful legal course of action a wrongfully deceased heir can bring in the event that no criminal charges can be filed. This article proposes that the best regulatory approach and tort liability course of action is through (1) treating prop …

Development Of Narrow-Spectrum Agents And Mray Inhibitors Targeting Multidrug-Resistant Mycobacterium Tuberculosis, Tomayo Ireti Berida

Electronic Theses and Dissertations

Tuberculosis (TB) is a major global health burden. This airborne infectious disease is caused by Mycobacterium tuberculosis (Mtb) and resulted in 1.6 million deaths globally in 2021. The emergence and spread of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) underscores the urgent need to discover and develop new agents, particularly those with narrow spectrum activity and those acting by novel mechanisms. Although broad-spectrum antibacterials have been successful in treating drug-resistant bacterial infections, including TB, there is a push toward the discovery and development of anti-TB agents with narrow-spectrum activity. This approach aims to limit the spread of resistance across …

The Efficacy Of Interventions Aimed At Reducing Early Childhood Toxic Stress: A Systematic Review And Meta-Analysis, Sheerah Neal Keith

Electronic Theses and Dissertations

The foundations of mental health and well-being are built in the first five years of life. Early childhood toxic stress (i.e., repeated, excessive, or prolonged activation of the body’s stress response systems) can undermine children’s sense of safety, sense of stability, and ability to form healthy relationships. The damaging effects of toxic stress can disrupt the normal course of brain, immune, and metabolic development, placing children at increased risk for mental and physical health problems that can last into adulthood. Counselors are uniquely qualified to help prevent and treat early childhood toxic stress. Yet, gaps between counseling theory, research, and …

“The War Will Be Over Sometime”: Female Authorship, Time, Trauma, And Healing In H.D.’S Wartime Works, Loren Samons

Electronic Theses and Dissertations

As a tripartite collection of poems, at first glance H.D.'s Trilogy appears vastly different from her semi-autobiographical novel, Bid Me to Live, but the two are not as removed from each other as their formats and publication timelines might indicate. In fact, their connectedness is much less discreet than many scholars have suggested. In addition to being thematically similar in terms of their considerations of time and gender, Bid Me to Live and Trilogy could be viewed as works in conversation with each other, reflecting the development of the female authorial voice along a timeline of war-related trauma progression and …

Novel Formulation Strategies For Oral And Ocular Drug Delivery, Samir Senapati

Electronic Theses and Dissertations

Nanoformulations such as nanoemulsions (NE), solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLCs) are colloidal particulate systems in the submicron size range and act as carriers of drug molecules. Their size varies from 10 to 1,000 nm (1). The capacity of these nanoparticles to permeate through many anatomical barriers, the prolonged release of their contents, and their stability on the nanometer scale have widely contributed to their efficacy in drug delivery. Owing to the advantages of nanoformulations, they were further explored in our studies to target different diseases like Dry eye disease (DED), glaucoma, and malaria.

Chapter 2 discusses …

Support Experiences Of Beginning Teachers In An Alternate Route Graduate Program In Mississippi, Elizabeth Young Sweeney

Electronic Theses and Dissertations

Beginning teachers are the group of teachers most at risk of leaving the profession, while research has shown that novice teachers who receive support, such as mentorship or cohort programs, are more likely to continue to teach than those who do not. This study explored supports that beginning teachers in an alternate route graduate program in Mississippi experience and perceive as beneficial. A qualitative research design utilizing a phenomenological approach was used to explore the lived experiences of participants and supports they experience as beginning teachers. Thirteen beginning teachers, each teaching for less than three years, were interviewed using a …

Phytochemical Constituents And Ppar Α/Γ Agonist Activity Of Juniperus Communis Berries And Comparison Studies Of J. Communis Berries To Saudi Juniperus Species (Arar): J. Procera And J. Phoenicea, Ibrahim Almarabi

Electronic Theses and Dissertations

Juniperus communis is distributed over a large geographical area mainly in the Northern Hemisphere across multiple continents making it the most known and medically used species among 75 other Juniperus species. One of the main traditional uses of J. communis that has been proven by several studies is its antidiabetic properties. An ethanolic extract of J. communis berries has shown promising antidiabetic results leading us to investigate its phytochemical constituents and to identify the active compounds that work through peroxisome proliferators–activated receptor (PPAR) α and γ receptors. Activation of both receptors by a drug candidate will achieve more benefits and …

Milk And Water Kefir: Microbial Diversity And Sensory Properties, Xia Li

Electronic Theses and Dissertations

Kefir is a fermented beverage that has become increasingly popular because of its proposed probiotic functions. It can be classified into two types: milk kefir and water kefir depending on the medium and inoculated starter culture. This dissertation summarizes work exploring the similarities and differences between milk and water kefir with respect to sensory properties and microbial composition. For the kefir sensory test, six milk and six water kefirs were evaluated on the sensory attributes (color, aroma, taste, and mouthfeel). Milk kefirs were assessed as sour and cheesy, followed by a creamy and thick mouthfeel. In contrast, water kefirs were …

The Influence Of Childhood Emotional Maltreatment And Exclusion On Distress Among Individuals With Social Anxiety Symptoms, Megan Perry

Electronic Theses and Dissertations

Social anxiety disorder (SAD) is one of the most pervasive psychological conditions affecting emerging adults. Previous literature has demonstrated the importance of biological influences, individual difference characteristics, negative parenting practices, peer victimization experiences, and trauma/adversity in the development and onset of SAD. One unique adverse experience is childhood emotional maltreatment (CEM) or parent-based emotional abuse and/or neglect. CEM has been associated with more severe and persistent social anxiety symptoms in adults. In young adulthood, adverse experiences such as peer exclusion can exacerbate the cognitive and behavioral processes of SAD. However, the impact of early CEM experiences has yet to be …

Design And Application Of Single And Multi-Gate Transistor-Based Analog Chaotic Maps, Maisha Sadia

Electronic Theses and Dissertations

Rapid advancement in technology has led to an increase in security threats, such as side-channel attacks and reverse engineering, which can potentially leak sensitive data or code to malicious parties. To address these challenges, researchers harness the inherent complexity of chaos-based computing. Leveraging chaos offers several advantages, including logic obfuscation, mitigation of power analysis attacks, and encryption of images and data.

The motivation has been to design hardware-efficient circuits that meet modern systems’ power, area, and performance requirements and provide enhanced security. We have introduced our novel one-dimensional discrete chaotic map circuits, designed using a 45nm CMOS process, although the …

Seafood Consumption During Harmful Algal Blooms: The Impact Of Information Regarding Safety And Health, Andrew Bechard, Corey Lang

Environmental and Natural Resource Economics Faculty Publications

Harmful algal blooms (HABs) can cause massive fish kills all over the world. However, some commercially caught species are safe to eat. The fish safe for consumption are vastly different from the fish that wash up on shore. Prior research finds this difference in edibility is mostly unknown by consumers, and that the misperception of unhealthy and unsafe fish is the dominant paradigm. To date, there has been minimal research on the effect of disseminating this information regarding seafood health to consumers, and how consumption habits would change during a bloom. We implement a survey that presents respondents with information …

Gratitude At Work, Ginger H. Williams

Library Faculty Publications

Guest columnist Ginger H. Williams is a new dean at Fort Hays State University, a regional comprehensive university in western Kansas. Ginger reflects on aspects of her work she is grateful for, such as a challenging renovation project and other new-to-her duties that help expand her skills. She also considers the many people whose support she relies upon. Readers are encouraged to consider what they are grateful for in their own professional lives and to find ways to express gratitude in a professional setting.

2023-January-01-Etsu's Dr. Pamela Mims Part Of National Biotech Project, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – Government, business and education leaders across the United States are working collaboratively to make clear to high school students and others that bio industrial manufacturing is a career path open to all.
 
Dr. Pamela Mims is one of several at East Tennessee State University powering this national endeavor. 
 
“We knew this movement was happening, and we knew it would be a huge area of job development in the future,” said Mims, a professor and associate dean of Research and Grants in the Clemmer College. “We also knew we needed to prepare students graduating from ETSU to …

Effect Of The Glucocorticoid Receptor Antagonist Pt150 On Acquisition And Escalation Of Fentanyl Self-Administration Following Early-Life Stress, Michael T. Bardo, Cassie M. Chandler, Emily D. Denehy, Benjamin A. Carper, Mark A. Prendergast, Tracy L. Nolen

Psychology Faculty Publications

There is comorbidity between posttraumatic stress disorder (PTSD) and opioid use disorder (OUD), perhaps because PTSD-like stressful experiences early in life alter the hypothalamic–pituitary-adrenal stress axis to increase the risk for OUD. The present study determined if the glucocorticoid receptor antagonist PT150 reduces the escalation of fentanyl intake in rats exposed to a “two-hit” model of early-life stress (isolation rearing and acute stress). Male and female rats were raised during adolescence in either isolated or social housing and then were given either a single acute stress (restraint and cold-water swim) or control treatment in young adulthood. Rats were then treated …

Coastal Prairie Enhancement Recommendations For The Baduwa’T Estuary Overlook, Kelly Corcoran, Gabe Acosta, Parker Bacon

Undergraduate Scholarship

The incorporation of native plants into the Baduwa’t Estuary overlook encourages the practice of preserving local tribal resources and promotes the valuable ecosystem services provided by the estuary’s bluff. The recent restoration and trail development of the Baduwa’t Estuary public access area highlighted the importance of collaboration with the Wiyot Tribe for incorporating culturally significant plants into the site. Wiyot tribal input should be utilized going forward in preserving cultural environmental resources and enhancing the native coastal prairie biodiversity of the site. An objective of this project is to create recommendations for the site's further development in collaboration with the …

The Power Of Education In A Globalised World: Challenging Geoeconomic Inequalities, Ozéias Rocha, Daniel Kamphambale, Cormac Macmahon, Jon Hans Coetzer, Lucía Morales

Articles

The globalization process has led to significant levels of controversy, as over the past few years, researchers have highlighted its negative connotations in terms of exacerbating economic inequalities, environmental degradation, exploitation of workers, loss of cultural diversity, and negative influence on democratic systems and financial stability. The negative connotation associated with the globalization process is not surprising. The implications for the global educational system significantly dominated by the influence of Western values, culture, and economic models based on consumerism to the detriment of traditional cultural and local identities have been eroded. The world economies are facing emerging areas of significant …

Composition, Nutritional And Physicochemical Properties Of Milk Fat Globule Membrane Enriched Ingredients For Use In Infant Nutrition Products, Pierre Ponchon

Theses

The aim of this thesis was to investigate the nutritional, techno-functional and physicochemical properties of milk fat globule membrane (MFGM) enriched whey protein concentrate (WPC) ingredients. This research focused on the physicochemical, nutritional, techno-functional, and microstructural properties of MFGM-enriched whey protein concentrate (WPC) powder ingredients, which included 3 MFGM-enriched WPC ingredients and a WPC ingredient co-enriched with α-lactalbumin and MFGM. These were compared to parallel stream (WPC 80 and whey protein isolate (WPI)) and upstream, whole milk powder (WMP) bovine derived ingredients of varying macromolecular composition, including MFGM-enrichment. The macromolecular compositions of the MFGM-enriched WPC ingredients included fat contents ranging …

The Satiating Potential Of Plant Proteins Transiting The Upper Gut., Leo Nunn

Theses

Increasing the feeling of fullness through modulation of satiety hormones by dietary proteins may be a promising daily approach in the prevention of unnecessary weight gain and in the maintenance of a healthy weight over our lifetime. The effects of animal sourced proteins on satiety hormone (GLP-1, PYY and CCK) has been well documented. However to meet the EU Green Deal of net zero greenhouse gas emissions by 2050, a 15-20 % dietary shift to plant proteins is required. This thesis examined the satiating potential of six plant protein ingredients, Teff, Oat Fibre, Lentil Protein Isolate, Buckwheat, Quinoa and Strong …

Automatic Seed Classification For Four Páramo Plant Species By Neural Networks And Optic Rgb Images, Camilo Franco, Manuela Osorio, Gwendolyn Peyre

Neotropical Biodiversity

No abstract provided.

The Impact Of Demographic And Background Information On Public Perceptions Of Sex Offenders, Rylee D. Perez

Master's Theses or Doctor of Nursing Practice

Many studies have examined the public’s perception of crime in the United State of America. As a whole, the public tends to favor harsh punishments and longer sentences for most crimes. In addition, the public tends to feel even more negatively toward sex offenders, often supporting punitive measures and restrictions when sex offenders are released, such as lifetime registration on the national sex offender registry. Although perceptions of crime, and sex offenses in general, appear to be negative among the general public, more recent research indicates that these perceptions can be influenced if information about the crime and offender is …

Bloodlines, Tyler Dallis

Master's Theses or Doctor of Nursing Practice

Connections are valuable in everyday life. Bloodlines speaks about my personal connections to my biological, adoptive, and found families, along with my heritage and what it means to be a contemporary Indigenous artist. I am not much of a sentimental person when it comes to physical objects, but I collect memories of the people closest to me. Through the process of collecting memories, I am creating a mental Rolodex of experience, people, things, and events from my life. When building my pieces, I braid these memories into the clay as I coil the form to completion. Embedding them into the …

Bat Activity And Insect Biomass On Mcconnell Airforce Base Compared To Surrounding Wichita Parks, Michaela Sielaff

Master's Theses or Doctor of Nursing Practice

Bats are bioindicators of the communities to which they belong, giving researchers insight into the overall health of those ecosystems. Bats are also very adaptable and are capable of tolerating urbanization. Some species, such as Lasiurus borealis and Lasionycteris noctivagans may even benefit from adjacent industrial and commercial land use, although this is not the case for all bat species. In 2021, we began acoustic and mist net surveys of bats at McConnell Air Force Base (MAFB, or “base”) in Wichita, KS. However, no bats were captured or seen during mist net surveys, although some were detected acoustically over a …